@article{nada_ali_soliman_shen_abou-zeid_hudson_2020, title={Multi-layer dressing made of laminated electrospun nanowebs and cellulose-based adhesive for comprehensive wound care}, volume={162}, ISSN={["1879-0003"]}, DOI={10.1016/j.ijbiomac.2020.06.184}, abstractNote={In this work, multi-layer wound dressing was made of laminated layers of electrospun fibers supported by adhesive sheet. Graft copolymerization of methyl methacrylate (MMA) and 2-Ethyl-1-hexyl acrylate (EHA) onto carboxymethyl cellulose (CMC) was conducted to obtain an adhesive sheet with 1.52 (N/cm2) loop tack, 1.7 (N/cm) peel strength and 25 s shear strength. Diclofenac sodium, anti-inflammatory drug, was loaded to the adhesive sheet with encapsulation efficiency 73%. The contact layer to wound was made of synthesized anti-bleeding agents, chitosan iodoacetamide (CI) loaded into electrospun polyvinyl alcohol (PVA) fibers. It was fabricated from fiber diameter 300 nm by electrospinning of 5% wt/v of CI (D.S. 18.7%) mixed with 10% wt/v PVA, at 20 kV and 17 cm airgap. The second, pain-relief layer was fabricated by encapsulating up to 50% wt/wt of capsaicin into gelatin nanofibers (197 nm) crosslinked by glyoxal. The third, antimicrobial layer was fabricated from PVA electrospun fibers loaded with 2% wt/wt gentamicin. Biocompatibility test showed insignificant adverse effects of the fabricated layers on fibroblast cells. Animal test on rat showed accelerated wound healing from 21 to 7 days for the multi-layer dressing. Histopathological findings corroborated the intactness of the epidermis layer of the treated samples.}, journal={INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, author={Nada, Ahmed A. and Ali, Eman A. and Soliman, Ahmed A. F. and Shen, Jialong and Abou-Zeid, Nabil Y. and Hudson, Samuel M.}, year={2020}, month={Nov}, pages={629–644} }
 @article{shen_nada_abou-zeid_hudson_2020, title={Synthesis of chitosan iodoacetamides via carbodiimide coupling reaction: Effect of degree of substitution on the hemostatic properties}, volume={229}, ISSN={["1879-1344"]}, DOI={10.1016/j.carbpol.2019.115522}, abstractNote={Uncontrolled hemorrhage continues to be the leading cause of death from traumatic injuries both in the battlefield and in the civilian life. Chitosan is among the very few materials that have made the short list of military recommended field-deployable hemostatic dressings. However, the detailed mechanism of its action is still not fully understood. Moreover, in the cases when patients developed coagulopathy, the efficacy of the dressings rely solely on those mechanisms that work outside of the regular blood coagulation cascade. In addition to the well-known erythrocyte agglutination, we proposed to use the reactive N-iodoacetyl group on a new chitosan derivative to accelerate hemostasis. In this paper, we describe the synthesis of chitosan iodoacetamide (CI) with considerations of the stoichiometry among the reagents, the choice of solvent, the pH of the reaction medium, and the reaction time. The reaction was confirmed by FT-IR, 1H and 13C NMR, elemental analysis, iodine content analysis, and SEM-EDS. Water contact angle measurements and Erythrocyte Sedimentation Rate (ESR) method were used to evaluate the hemostatic potential of the newly synthesized CI as a function of their degree of substitution (DS). The range of DS was 5.9% to 27.8% for CI. The mid-range of DS gave the best results for the ESR. CIs exhibit favorable cytocompatibilities up to DS 18.7 compared to the generic unmodified chitosan. In general, the biocompatibility of chitosan iodoacetamide slightly declined with increasing the iodide content up to DS 21.5 owing to its affinity to SH groups of cells.}, journal={CARBOHYDRATE POLYMERS}, author={Shen, Jialong and Nada, Ahmed Ali and Abou-Zeid, Nabil Yousrie and Hudson, Samuel M.}, year={2020}, month={Feb} }
 @article{nada_abdellatif_soliman_shen_hudson_abou-zeid_2019, title={Fabrication and bioevaluation of a medicated electrospun mat based on azido-cellulose acetate via click chemistry}, volume={26}, ISSN={["1572-882X"]}, DOI={10.1007/s10570-019-02739-9}, number={18}, journal={CELLULOSE}, author={Nada, Ahmed A. and Abdellatif, Faten Hassan Hassan and Soliman, Ahmed A. F. and Shen, Jialong and Hudson, Samuel M. and Abou-Zeid, Nabil Y.}, year={2019}, month={Dec}, pages={9721–9736} }