Austin Browning

Works (7)

Updated: April 25th, 2025 17:42

2024 article

Carbon‐13 Hyperpolarization of α‐Ketocarboxylates with Parahydrogen in Reversible Exchange

McBride, S. J., MacCulloch, K., TomHon, P., Browning, A., Meisel, S., Abdulmojeed, M., … Theis, T. (2024, October 4). ChemMedChem, Vol. 12.

By: S. McBride n, K. MacCulloch n, P. TomHon* , A. Browning n, S. Meisel n, M. Abdulmojeed n, B. Goodson *, E. Chekmenev *, T. Theis n 

author keywords: Hyperpolarization; NMR; SABRE; Alpha-ketocarboxylate; Parahydrogen
MeSH headings : Carbon Isotopes / chemistry; Hydrogen / chemistry; Molecular Structure; Carboxylic Acids / chemistry
topics (OpenAlex): Advanced NMR Techniques and Applications; Solid-state spectroscopy and crystallography; Electron Spin Resonance Studies; Atomic and Subatomic Physics Research
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 11, 2024

2024 article

SABRE-SHEATH Hyperpolarization of [1,5-13C2]Z-OMPD for Noninvasive pH Sensing

Abdulmojeed, M. B., Grashei, M., Dilday, S., Wodtke, P., McBride, S., Davidsson, A., … Theis, T. (2024, November 18). ACS Sensors, Vol. 9, pp. 6372–6381.

By: M. Abdulmojeed n, M. Grashei *, S. Dilday n, P. Wodtke *, S. McBride n, A. Davidsson n, E. Curran n, K. MacCulloch n ...

author keywords: NMR; hyperpolarization; [1,5-C-13(2)]Z-OMPD; SABRE-SHEATH; pH sensing
MeSH headings : Hydrogen-Ion Concentration; Carbon Isotopes / chemistry; Density Functional Theory
topics (OpenAlex): Advanced NMR Techniques and Applications; Electron Spin Resonance Studies; Solid-state spectroscopy and crystallography
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 24, 2025

2023 article

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1–13C]pyruvate in vivo

MacCulloch, K., Browning, A., Bedoya, D. O. G., McBride, S. J., Abdulmojeed, M. B., Dedesma, C., … Theis, T. (2023, July 13). Journal of Magnetic Resonance Open, Vol. 16-17.

By: K. MacCulloch n, A. Browning n, D. Bedoya *, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson *, M. Rosen * ...

Contributors: K. MacCulloch n, A. Browning n, D. Guarin Bedoya *, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson *, M. Rosen * ...

author keywords: Hyperpolarized MRI; Parahydrogen; SABRE; Metabolic imaging
topics (OpenAlex): Advanced NMR Techniques and Applications; Solid-state spectroscopy and crystallography; Electron Spin Resonance Studies
TL;DR: A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 15, 2023

2023 article

Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). Analytical Chemistry, Vol. 5, pp. 7822–7829.

By: K. MacCulloch n, A. Browning n, P. TomHon n , S. Lehmkuhl n, E. Chekmenev * & T. Theis n 

Contributors: K. MacCulloch n, A. Browning n, P. Tomhon n , S. Lehmkuhl n, E. Chekmenev * & T. Theis n 

MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
topics (OpenAlex): Advanced NMR Techniques and Applications; Atomic and Subatomic Physics Research; Solid-state spectroscopy and crystallography
TL;DR: The nitrile 15N sites enable long-lasting polarization storage with [15N]T1 over 9 min, enabling signal detection from a single hyperpolarization cycle for over 30 min, and this sensitivity gain enables polarization studies at naturally abundant 15N enrichment level (0.4%). (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 11, 2023

2023 article

Spin dynamics of [1,2-13C2]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields

Browning, A., Macculloch, K., TomHon, P., Mandzhieva, I., Chekmenev, E. Y., Goodson, B. M., … Theis, T. (2023, January 1). Physical Chemistry Chemical Physics.

By: A. Browning n, K. Macculloch n, P. TomHon n , I. Mandzhieva n, E. Chekmenev *, B. Goodson *, S. Lehmkuhl n, T. Theis n 

Contributors: A. Browning n, K. Macculloch n, P. TomHon n , I. Mandzhieva n, E. Chekmenev *, B. Goodson *, S. Lehmkuhl n, T. Theis n 

topics (OpenAlex): Advanced NMR Techniques and Applications; Electron Spin Resonance Studies; Atomic and Subatomic Physics Research
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 13, 2023

2022 article

Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-13C]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH

Nantogma, S., Eriksson, S. L., Adelabu, I., Mandzhieva, I., Browning, A., TomHon, P., … Chekmenev, E. Y. (2022, November 28). The Journal of Physical Chemistry A, Vol. 11, pp. 9114–9123.

By: S. Nantogma *, S. Eriksson *, I. Adelabu *, I. Mandzhieva n, A. Browning n, P. TomHon n , W. Warren *, T. Theis n , B. Goodson *, E. Chekmenev *

Contributors: S. Nantogma *, S. Eriksson *, I. Adelabu *, I. Mandzhieva n, A. Browning n, P. TomHon n , W. Warren *, T. Theis n , B. Goodson *, E. Chekmenev *

MeSH headings : Pyruvic Acid
topics (OpenAlex): Advanced NMR Techniques and Applications; Solid-state spectroscopy and crystallography; Electron Spin Resonance Studies
TL;DR: The application of microtesla pulses is studied to investigate their effect on C-13 polarization efficiency, compared to that of conventional SABRE-SHEATH employing a static field, to provide the matching conditions of polarization transfer from parahydrogen-derived hydrides to the 13C-1 nucleus. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 29, 2022

2021 article

Hyperpolarization of common antifungal agents with SABRE

MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 14). Magnetic Resonance in Chemistry, Vol. 6, pp. 1225–1235.

By: K. MacCulloch n, P. Tomhon n , A. Browning n, E. Akeroyd n, S. Lehmkuhl  n, E. Chekmenev *, T. Theis n 

Contributors: K. MacCulloch n, P. Tomhon n , A. Browning n, E. Akeroyd n, S. Lehmkuhl  n, E. Chekmenev *, T. Theis n 

author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
topics (OpenAlex): Advanced NMR Techniques and Applications; Solid-state spectroscopy and crystallography; Atomic and Subatomic Physics Research
TL;DR: This work broadens the SABRE substrate scope and provides mechanistic and kinetic insights into the HP process, optimizing the polarization with respect to temperature and the polarization transfer field (PTF) for 1 H nuclei in the millitesla regime and for 15 N nucleiIn the microtesla regime, which provides detailed insights into exchange kinetics and spin evolution. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 21, 2021

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