Works (5)

Updated: January 22nd, 2024 08:12

2023 journal article

Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo

JOURNAL OF MAGNETIC RESONANCE OPEN, 16-17.

By: K. Macculloch n, A. Browning n, D. Bedoya*, S. Mcbride n, M. Abdulmojeed n, C. Dedesma, B. Goodson*, M. Rosen* ...

Contributors: K. MacCulloch n, A. Browning n, D. Guarin Bedoya*, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson*, M. Rosen* ...

author keywords: Hyperpolarized MRI; Parahydrogen; SABRE; Metabolic imaging
TL;DR: A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID
Added: November 15, 2023

2023 article

Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole

MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). ANALYTICAL CHEMISTRY, Vol. 5.

By: K. MacCulloch n, A. Browning n, P. TomHon n, S. Lehmkuhl n, E. Chekmenev* & T. Theis n

Contributors: K. MacCulloch n, A. Browning n, P. Tomhon n, S. Lehmkuhl n, E. Chekmenev* & T. Theis n

MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
TL;DR: The nitrile 15N sites enable long-lasting polarization storage with [15N]T1 over 9 min, enabling signal detection from a single hyperpolarization cycle for over 30 min, and this sensitivity gain enables polarization studies at naturally abundant 15N enrichment level (0.4%). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: May 11, 2023

2023 journal article

Spin dynamics of [1,2-C-13(2)]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25(24), 16446–16458.

Contributors: A. Browning n, K. Macculloch n, P. TomHon n, I. Mandzhieva n, E. Chekmenev*, B. Goodson*, S. Lehmkuhl n, T. Theis n

UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 13, 2023

2022 article

Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-C-13]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH

Nantogma, S., Eriksson, S. L., Adelabu, I., Mandzhieva, I., Browning, A., TomHon, P., … Chekmenev, E. Y. (2022, November 28). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 11.

MeSH headings : Pyruvic Acid
TL;DR: The application of microtesla pulses is studied to investigate their effect on C-13 polarization efficiency, compared to that of conventional SABRE-SHEATH employing a static field, to provide the matching conditions of polarization transfer from parahydrogen-derived hydrides to the 13C-1 nucleus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: November 29, 2022

2021 article

Hyperpolarization of common antifungal agents with SABRE

MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 20). MAGNETIC RESONANCE IN CHEMISTRY, Vol. 6.

By: K. MacCulloch n, P. Tomhon n, A. Browning n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev*, T. Theis n

Contributors: K. MacCulloch n, P. Tomhon n, A. Browning n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev*, T. Theis n

author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
TL;DR: This work broadens the SABRE substrate scope and provides mechanistic and kinetic insights into the HP process, optimizing the polarization with respect to temperature and the polarization transfer field (PTF) for 1 H nuclei in the millitesla regime and for 15 N nucleiIn the microtesla regime, which provides detailed insights into exchange kinetics and spin evolution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: June 21, 2021

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