Works (5)
Updated: January 22nd, 2024 08:12
2023 journal article
Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo
JOURNAL OF MAGNETIC RESONANCE OPEN, 16-17.
Contributors: K. MacCulloch n, n, D. Guarin Bedoya, S. McBride n, M. Abdulmojeed n, C. Dedesma, B. Goodson *, M. Rosen *
author keywords: Hyperpolarized MRI; Parahydrogen; SABRE; Metabolic imaging
TL;DR:
A first demonstration of SABRE-hyperpolarized contrast detected in vivo, specifically using hyperpolarized [1-13C]pyruvate is described, illustrating the utility of combining lower-cost MRI systems with simple, low-cost hyperpolarization chemistry to develop safe, and scalable molecular imaging.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 15, 2023
2023 article
Parahydrogen in Reversible Exchange Induces Long-Lived 15N Hyperpolarization of Anticancer Drugs Anastrozole and Letrozole
MacCulloch, K., Browning, A., TomHon, P., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2023, May 10). ANALYTICAL CHEMISTRY, Vol. 5.
Contributors: K. MacCulloch n, n, P. Tomhon n , S. Lehmkuhl n, E. Chekmenev * & T. Theis n
MeSH headings : Letrozole; Anastrozole; Magnetic Resonance Spectroscopy; Magnetic Resonance Imaging; Antineoplastic Agents / pharmacology
TL;DR:
The nitrile 15N sites enable long-lasting polarization storage with [15N]T1 over 9 min, enabling signal detection from a single hyperpolarization cycle for over 30 min, and this sensitivity gain enables polarization studies at naturally abundant 15N enrichment level (0.4%).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 11, 2023
2023 journal article
Spin dynamics of [1,2-C-13(2)]pyruvate hyperpolarization by parahydrogen in reversible exchange at micro Tesla fields
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 25(24), 16446–16458.
Contributors: n, K. Macculloch n, P. TomHon n , I. Mandzhieva n, E. Chekmenev *, B. Goodson *, S. Lehmkuhl n, T. Theis n
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 13, 2023
2022 article
Interplay of Near-Zero-Field Dephasing, Rephasing, and Relaxation Dynamics and [1-C-13]Pyruvate Polarization Transfer Efficiency in Pulsed SABRE-SHEATH
Nantogma, S., Eriksson, S. L., Adelabu, I., Mandzhieva, I., Browning, A., TomHon, P., … Chekmenev, E. Y. (2022, November 28). JOURNAL OF PHYSICAL CHEMISTRY A, Vol. 11.
Contributors: S. Nantogma *, S. Eriksson *, I. Adelabu *, I. Mandzhieva n, n, P. TomHon n , W. Warren *, T. Theis n , B. Goodson *, E. Chekmenev *
MeSH headings : Pyruvic Acid
TL;DR:
The application of microtesla pulses is studied to investigate their effect on C-13 polarization efficiency, compared to that of conventional SABRE-SHEATH employing a static field, to provide the matching conditions of polarization transfer from parahydrogen-derived hydrides to the 13C-1 nucleus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 29, 2022
2021 article
Hyperpolarization of common antifungal agents with SABRE
MacCulloch, K., Tomhon, P., Browning, A., Akeroyd, E., Lehmkuhl, S., Chekmenev, E. Y., & Theis, T. (2021, June 20). MAGNETIC RESONANCE IN CHEMISTRY, Vol. 6.
Contributors: K. MacCulloch n, P. Tomhon n , n, E. Akeroyd n, S. Lehmkuhl n, E. Chekmenev *, T. Theis n
author keywords: N-15; H-1; antifungals; clotrimazole and fluconazole; contrast agents; hyperpolarization; NMR; parahydrogen; SABRE; voriconazole
MeSH headings : Antifungal Agents; Catalysis; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nitrogen Isotopes
TL;DR:
This work broadens the SABRE substrate scope and provides mechanistic and kinetic insights into the HP process, optimizing the polarization with respect to temperature and the polarization transfer field (PTF) for 1 H nuclei in the millitesla regime and for 15 N nucleiIn the microtesla regime, which provides detailed insights into exchange kinetics and spin evolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 21, 2021
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