@article{hecht_anderson_castel_griffin_hespel_nelson_sun_2021, title={Agreement of Magnetic Resonance Imaging With Computed Tomography in the Assessment for Acute Skull Fractures in a Canine and Feline Cadaver Model}, volume={8}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2021.603775}, abstractNote={Computed tomography (CT) is the imaging modality of choice to evaluate patients with acute head trauma. However, magnetic resonance imaging (MRI) may be chosen in select cases. The objectives of this study were to evaluate the agreement of MRI with CT in the assessment for presence or absence of acute skull fractures in a canine and feline cadaver model, compare seven different MRI sequences (T1-W, T2-W, T2-FLAIR, PD-W, T2*-W, “SPACE” and “VIBE”), and determine agreement of four different MRI readers with CT data. Pre- and post-trauma CT and MRI studies were performed on 10 canine and 10 feline cadaver heads. Agreement of MRI with CT as to presence or absence of a fracture was determined for 26 individual osseous structures and four anatomic regions (cranium, face, skull base, temporomandibular joint). Overall, there was 93.5% agreement in assessing a fracture as present or absent between MRI and CT, with a significant difference between the pre and post trauma studies (99.4 vs. 87.6%;p< 0.0001; OR 0.042; 95% CI 0.034–0.052). There was no significant difference between dogs and cats. The agreement for the different MRI sequences with CT ranged from 92.6% (T2*-W) to 94.4% (PD-W). There was higher agreement of MRI with CT in the evaluation for fractures of the face than other anatomic regions. Agreement with CT for individual MRI readers ranged from 92.6 to 94.7%. A PD-W sequence should be added to the MR protocol when evaluating the small animal head trauma patient.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Hecht, Silke and Anderson, Kimberly M. and Castel, Aude and Griffin, John F. and Hespel, Adrien-Maxence and Nelson, Nathan and Sun, Xiaocun}, year={2021}, month={Apr} }
 @article{castel_olby_ru_mariani_muñana_early_2019, title={Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study}, volume={15}, ISSN={1746-6148}, url={http://dx.doi.org/10.1186/s12917-019-2186-0}, DOI={10.1186/s12917-019-2186-0}, abstractNote={Abstract}, number={1}, journal={BMC Veterinary Research}, publisher={Springer Science and Business Media LLC}, author={Castel, Aude and Olby, Natasha J. and Ru, Hongyu and Mariani, Christopher L. and Muñana, Karen R. and Early, Peter J.}, year={2019}, month={Dec} }
 @article{dorman_foster_olesnevich_bolon_castel_sokolsky-papkov_mariani_2018, title={Toxicity associated with ingestion of a polyacrylic acid hydrogel dog pad}, volume={30}, ISSN={["1943-4936"]}, url={http://dx.doi.org/10.1177/1040638718782583}, DOI={10.1177/1040638718782583}, abstractNote={ Superabsorbent sodium polyacrylate polymeric hydrogels that retain large amounts of liquids are used in disposable diapers, sanitary napkins, and other applications. These polymers are generally considered “nontoxic” with acute oral median lethal doses (LD50) >5 g/kg. Despite this favorable toxicity profile, we identified a novel toxic syndrome in dogs and rats following the ingestion of a commercial dog pad composed primarily of a polyacrylic acid hydrogel. Inappropriate mentation, cerebellar ataxia, vomiting, and intention tremors were observed within 24 h after the ingestion of up to 15.7 g/kg of the hydrogel by an adult, castrated male Australian Shepherd mix. These observations prompted an experimental study in rats to further characterize the toxicity of the hydrogel. Adult, female Sprague Dawley rats ( n = 9) were assessed before and after hydrogel ingestion (2.6–19.2 g/kg over 4 h) using a functional observation battery and spontaneous motor activity. Clinical signs consistent with neurotoxicity emerged in rats as early as 2 h after the end of hydrogel exposure, including decreased activity in an open field, hunched posture, gait changes, reduced reaction to handling, decreased muscle tone, and abnormal surface righting. Hydrogel-exposed rats also had reduced motor activity when compared with pre-exposure baseline data. Rats that ingested the hydrogel did not develop nervous system lesions. These findings support the conclusion that some pet pad hydrogel products can induce acute neurotoxicity in animals under high-dose exposure conditions. }, number={5}, journal={JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION}, author={Dorman, David C. and Foster, Melanie L. and Olesnevich, Brooke and Bolon, Brad and Castel, Aude and Sokolsky-Papkov, Marina and Mariani, Christopher L.}, year={2018}, month={Sep}, pages={708–714} }
 @article{castel_olby_mariani_muñana_early_2017, title={Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion}, volume={31}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.14829}, DOI={10.1111/jvim.14829}, abstractNote={BackgroundProgressive myelomalacia (PMM) is a catastrophic disease associated with acute intervertebral disc extrusion (IVDE). Published data on the clinical characteristics of this disease are limited.}, number={6}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Castel, A. and Olby, N.J. and Mariani, C.L. and Muñana, K.R. and Early, P.J.}, year={2017}, month={Sep}, pages={1782–1789} }
 @article{castel_olby_2016, title={Acute change in neurological level following canine intervertebral disc herniation}, volume={57}, ISSN={0022-4510}, url={http://dx.doi.org/10.1111/jsap.12445}, DOI={10.1111/jsap.12445}, abstractNote={Journal of Small Animal PracticeVolume 57, Issue 4 p. 220-220 IMAGES IN SMALL ANIMAL PRACTICE Acute change in neurological level following canine intervertebral disc herniation A. Castel, A. Castel Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607 USASearch for more papers by this authorN. J. Olby, Corresponding Author N. J. Olby Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607 USA Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, 27607 USACorresponding author email: njolby@ncsu.uedSearch for more papers by this author A. Castel, A. Castel Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607 USASearch for more papers by this authorN. J. Olby, Corresponding Author N. J. Olby Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, 27607 USA Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, 27607 USACorresponding author email: njolby@ncsu.uedSearch for more papers by this author First published: 18 March 2016 https://doi.org/10.1111/jsap.12445Citations: 3Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume57, Issue4April 2016Pages 220-220 RelatedInformation}, number={4}, journal={Journal of Small Animal Practice}, publisher={Wiley}, author={Castel, A. and Olby, N. J.}, year={2016}, month={Mar}, pages={220–220} }