Works (32)

2016 journal article

Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection

Proceedings of the National Academy of Sciences of the United States of America, 113(41), E6080–6088.

By: J. Maciag, S. Mackenzie, M. Tucker, J. Schipper, P. Swartz & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Modifying caspase-3 activity by altering allosteric networks

Biochemistry, 53(48), 7582–7595.

By: C. Cade, P. Swartz, S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Redesigning the procaspase-8 dimer interface for improved dimerization

Protein Science, 23(4), 442–453.

By: C. Ma, S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Lengthening the intersubunit linker of procaspase 3 leads to constitutive activation

Biochemistry, 52(36), 6219–6231.

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Slow folding and assembly of a procaspase-3 interface variant

Biochemistry, 52(20), 3415–3427.

By: S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Allosteric modulation of caspase 3 through mutagenesis

Bioscience Reports, 32(4), 401–411.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A bifunctional allosteric site in the dimer interface of procaspase-3

Biophysical Chemistry, 159(1), 100–109.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3

Archives of Biochemistry and Biophysics, 508(1), 31–38.

By: J. Walters, P. Swartz, C. Mattos & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2010 review

The potential for caspases in drug discovery

[Review of ]. Current Opinion in Drug Discovery & Development, 13(5), 568–576.

By: S. MacKenzie, J. Schipper & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis

Biochemical Journal (London, England : 1984), 424, 335–345.

By: J. Walters, C. Pop, F. Scott, M. Drag, P. Swartz, C. Mattos, G. Salvesen, A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Folding and assembly kinetics of procaspase-3

Protein Science, 18(12), 2500–2517.

By: S. Milam & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2009 review

Practical approaches to protein folding and assembly: Spectroscopic strategies in thermodynamics and kinetics

[Review of ]. Methods in enzymology: biothermodynamics,vol 455, part a, 455, 1–39.

By: J. Walters, S. Milam & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2008 review

Minimizing frustration by folding in an aqueous environment

[Review of ]. Archives of Biochemistry and Biophysics, 469(1), 118–131.

By: C. Mattos & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Protein folding: Are we there yet?

Archives of Biochemistry and Biophysics, 469(1), 1–3.

By: A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2008 review

Targeting cell death in tumors by activating Caspases

[Review of ]. Current Cancer Drug Targets, 8(2), 98–109.

By: S. MacKenzie & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Rapid folding and unfolding of Apaf-1 CARD

Journal of Molecular Biology, 369(1), 290–304.

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker

Protein Expression and Purification, 47(1), 311–318.

By: B. Feeney, E. Soderblom, M. Goshe & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Role of loop bundle hydrogen bonds in the maturation and activity of (pro) caspase-3

Biochemistry, 45(44), 13249–13263.

By: B. Feeney, C. Pop, P. Swartz, C. Mattos & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK

Protein Science, 15(3), 395–409.

By: Y. Chen & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Characterization and enzymatic degradation of Sup35NM, a yeast prion-like protein

Protein Science, 14(9), 2228–2235.

By: C. Chen, K. Rojanatavorn, A. Clark & J. Shih

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Reassembly of active caspase-3 is facilitated by the propeptide

Journal of Biological Chemistry, 280(48), 39772–39785.

By: B. Feeney & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

pH effects on the stability and dimerization of procaspase-3

Protein Science, 14(1), 24–36.

By: K. Bose & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Evaluation of the DNA binding tendencies of the transition state regulator AbrB

Biochemistry, 43(51), 16106–16118.

By: B. Bobay, L. Benson, S. Naylor, B. Feeney, A. Clark, M. Goshe, M. Strauch, R. Thompson, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3

Biochemical Journal (London, England : 1984), 384(Dec 15 2004), 515–525.

By: B. Feeney, C. Pop, A. Tripathy & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Kinetic traps in the folding/unfolding of procaspase-1 CARD domain

Protein Science, 13(8), 2196–2206.

By: Y. Chen & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3

Biochemistry, 42(42), 12298–12310.

By: K. Bose, C. Pop, B. Feeney & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Equilibrium and kinetic folding of a alpha-helical Greek key protein domain: Caspase recruitment domain (CARD) of RICK

Biochemistry, 42(20), 6310–6320.

By: Y. Chen & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Mutations in the procaspase-3 dimer interface affect the activity of the zymogen

Biochemistry, 42(42), 12311–12320.

By: C. Pop, B. Feeney, A. Tripathy & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

The C-terminal tail of arabidopsis 14-3-3 omega functions as an autoinhibitor and may contain a tenth alpha-helix

Plant Journal, 34(4), 473–484.

By: W. Shen, A. Clark & S. Huber

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Dimeric procaspase-3 unfolds via a four-state equilibrium process

Biochemistry, 40(47), 14236–14242.

By: K. Bose & A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer

Biochemistry, 40(47), 14224–14235.

By: C. Pop, Y. Chen, B. Smith, K. Bose, B. Bobay, A. Tripathy, S. Franzen, A. Clark

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

A rapid chromatographic method to separate the subunits of bacterial luciferase in urea-containing buffer

Bioluminescence and Chemiluminescence, Pt. C, 305, 157–164.

By: A. Clark, B. Noland & T. Baldwin

Source: NC State University Libraries
Added: August 6, 2018