@article{shrestha_tung_grinshpon_swartz_hamilton_dimos_mydlarz_clark_2020, title={Caspases from scleractinian coral show unique regulatory features}, volume={295}, ISSN={["1083-351X"]}, url={http://dx.doi.org/10.1074/jbc.ra120.014345}, DOI={10.1074/jbc.RA120.014345}, number={43}, journal={JOURNAL OF BIOLOGICAL CHEMISTRY}, publisher={Elsevier BV}, author={Shrestha, Suman and Tung, Jessica and Grinshpon, Robert D. and Swartz, Paul and Hamilton, Paul T. and Dimos, Bradford and Mydlarz, Laura and Clark, A. Clay}, year={2020}, month={Oct}, pages={14578–14591} } @article{maciag_mackenzie_tucker_schipper_swartz_clark_2016, title={Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection}, volume={113}, ISSN={["0027-8424"]}, DOI={10.1073/pnas.1603549113}, number={41}, journal={PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA}, author={Maciag, Joseph J. and Mackenzie, Sarah H. and Tucker, Matthew B. and Schipper, Joshua L. and Swartz, Paul and Clark, A. Clay}, year={2016}, month={Oct}, pages={E6080–E6088} } @article{cade_swartz_mackenzie_clark_2014, title={Modifying Caspase-3 Activity by Altering Allosteric Networks}, volume={53}, ISSN={["0006-2960"]}, DOI={10.1021/bi500874k}, number={48}, journal={BIOCHEMISTRY}, author={Cade, Christine and Swartz, Paul and MacKenzie, Sarah H. and Clark, A. Clay}, year={2014}, month={Dec}, pages={7582–7595} } @article{ma_mackenzie_clark_2014, title={Redesigning the procaspase-8 dimer interface for improved dimerization}, volume={23}, number={4}, journal={Protein Science}, author={Ma, C. X. and MacKenzie, S. H. and Clark, A. C.}, year={2014}, pages={442–453} } @article{mackenzie_schipper_england_thomas_blackburn_swartz_clark_2013, title={Lengthening the Intersubunit Linker of Procaspase 3 Leads to Constitutive Activation}, volume={52}, ISSN={["0006-2960"]}, DOI={10.1021/bi400793s}, number={36}, journal={BIOCHEMISTRY}, author={MacKenzie, Sarah H. and Schipper, Joshua L. and England, Erika J. and Thomas, Melvin E., III and Blackburn, Kevin and Swartz, Paul and Clark, A. Clay}, year={2013}, month={Sep}, pages={6219–6231} } @article{mackenzie_clark_2013, title={Slow folding and assembly of a procaspase-3 interface variant}, volume={52}, number={20}, journal={Biochemistry}, author={MacKenzie, S. H. and Clark, A. C.}, year={2013}, pages={3415–3427} } @article{walters_schipper_swartz_mattos_clark_2012, title={Allosteric modulation of caspase 3 through mutagenesis}, volume={32}, ISSN={["0144-8463"]}, DOI={10.1042/bsr20120037}, number={4}, journal={BIOSCIENCE REPORTS}, author={Walters, Jad and Schipper, Joshua L. and Swartz, Paul and Mattos, Carla and Clark, A. Clay}, year={2012}, month={Aug}, pages={401–411} } @article{schipper_mackenzie_sharma_clark_2011, title={A bifunctional allosteric site in the dimer interface of procaspase-3}, volume={159}, ISSN={["1873-4200"]}, DOI={10.1016/j.bpc.2011.05.013}, number={1}, journal={BIOPHYSICAL CHEMISTRY}, author={Schipper, Joshua L. and MacKenzie, Sarah H. and Sharma, Anil and Clark, A. Clay}, year={2011}, month={Nov}, pages={100–109} } @article{walters_swartz_mattos_clark_2011, title={Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3}, volume={508}, ISSN={["1096-0384"]}, DOI={10.1016/j.abb.2011.01.011}, number={1}, journal={ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS}, author={Walters, Jad and Swartz, Paul and Mattos, Carla and Clark, A. Clay}, year={2011}, month={Apr}, pages={31–38} } @misc{mackenzie_schipper_clark_2010, title={The potential for caspases in drug discovery}, volume={13}, number={5}, journal={Current Opinion in Drug Discovery & Development}, author={MacKenzie, S. H. and Schipper, J. L. and Clark, A. C.}, year={2010}, pages={568–576} } @article{walters_pop_scott_drag_swartz_mattos_salvesen_clark_2009, title={A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis}, volume={424}, ISSN={["1470-8728"]}, DOI={10.1042/bj20090825}, journal={BIOCHEMICAL JOURNAL}, author={Walters, Jad and Pop, Cristina and Scott, Fiona L. and Drag, Marcin and Swartz, Paul and Mattos, Carla and Salvesen, Guy S. and Clark, A. Clay}, year={2009}, month={Dec}, pages={335–345} } @article{milam_clark_2009, title={Folding and assembly kinetics of procaspase-3}, volume={18}, ISSN={["1469-896X"]}, DOI={10.1002/pro.259}, number={12}, journal={PROTEIN SCIENCE}, author={Milam, Sara L. and Clark, A. Clay}, year={2009}, month={Dec}, pages={2500–2517} } @misc{walters_milam_clark_2009, title={Practical approaches to protein folding and assembly: Spectroscopic strategies in thermodynamics and kinetics}, volume={455}, journal={Methods in enzymology: biothermodynamics,vol 455, part a}, author={Walters, J. and Milam, S. L. and Clark, A. C.}, year={2009}, pages={1–39} } @misc{mattos_clark_2008, title={Minimizing frustration by folding in an aqueous environment}, volume={469}, number={1}, journal={Archives of Biochemistry and Biophysics}, author={Mattos, C. and Clark, A. C.}, year={2008}, pages={118–131} } @article{clark_2008, title={Protein folding: Are we there yet?}, volume={469}, number={1}, journal={Archives of Biochemistry and Biophysics}, author={Clark, A. C.}, year={2008}, pages={1–3} } @misc{mackenzie_clark_2008, title={Targeting cell death in tumors by activating Caspases}, volume={8}, number={2}, journal={Current Cancer Drug Targets}, author={MacKenzie, S. H. and Clark, A. C.}, year={2008}, pages={98–109} } @article{milam_nicely_feeney_mattos_clark_2007, title={Rapid folding and unfolding of Apaf-1 CARD}, volume={369}, ISSN={["0022-2836"]}, DOI={10.1016/j.jmb.2007.02.105}, number={1}, journal={JOURNAL OF MOLECULAR BIOLOGY}, author={Milam, Sara L. and Nicely, Nathan I. and Feeney, Brett and Mattos, Carla and Clark, A. Clay}, year={2007}, month={May}, pages={290–304} } @article{feeney_soderblom_goshe_clark_2006, title={Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker}, volume={47}, ISSN={1046-5928}, url={http://dx.doi.org/10.1016/j.pep.2005.10.005}, DOI={10.1016/j.pep.2005.10.005}, number={1}, journal={Protein Expression and Purification}, publisher={Elsevier BV}, author={Feeney, Brett and Soderblom, Erik J. and Goshe, Michael B. and Clark, A. Clay}, year={2006}, month={May}, pages={311–318} } @article{feeney_pop_swartz_mattos_clark_2006, title={Role of loop bundle hydrogen bonds in the maturation and activity of (pro) caspase-3}, volume={45}, ISSN={["0006-2960"]}, DOI={10.1021/bi0611964}, number={44}, journal={BIOCHEMISTRY}, author={Feeney, Brett and Pop, Cristina and Swartz, Paul and Mattos, Carla and Clark, A. Clay}, year={2006}, month={Nov}, pages={13249–13263} } @article{chen_clark_2006, title={Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK}, volume={15}, ISSN={["1469-896X"]}, DOI={10.1110/ps.051943006}, number={3}, journal={PROTEIN SCIENCE}, author={Chen, YR and Clark, AC}, year={2006}, month={Mar}, pages={395–409} } @article{chen_rojanatavorn_clark_shih_2005, title={Characterization and enzymatic degradation of Sup35NM, a yeast prion-like protein}, volume={14}, ISSN={["1469-896X"]}, DOI={10.1110/ps.041234405}, number={9}, journal={PROTEIN SCIENCE}, author={Chen, CY and Rojanatavorn, K and Clark, AC and Shih, JCH}, year={2005}, month={Sep}, pages={2228–2235} } @article{feeney_clark_2005, title={Reassembly of active caspase-3 is facilitated by the propeptide}, volume={280}, ISSN={["1083-351X"]}, DOI={10.1074/jbc.M505834200}, number={48}, journal={JOURNAL OF BIOLOGICAL CHEMISTRY}, author={Feeney, B and Clark, AC}, year={2005}, month={Dec}, pages={39772–39785} } @article{bose_clark_2005, title={pH effects on the stability and dimerization of procaspase-3}, volume={14}, number={1}, journal={Protein Science}, author={Bose, K. and Clark, A. C.}, year={2005}, pages={24–36} } @article{bobay_benson_naylor_feeney_clark_goshe_strauch_thompson_cavanagh_2004, title={Evaluation of the DNA Binding Tendencies of the Transition State Regulator AbrB†}, volume={43}, ISSN={0006-2960 1520-4995}, url={http://dx.doi.org/10.1021/bi048399h}, DOI={10.1021/bi048399h}, number={51}, journal={Biochemistry}, publisher={American Chemical Society (ACS)}, author={Bobay, Benjamin G. and Benson, Linda and Naylor, Stephen and Feeney, Brett and Clark, A. Clay and Goshe, Michael B. and Strauch, Mark A. and Thompson, Richele and Cavanagh, John}, year={2004}, month={Dec}, pages={16106–16118} } @article{feeney_pop_tripathy_clark_2004, title={Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3}, volume={384}, number={Dec 15 2004}, journal={Biochemical Journal (London, England : 1984)}, author={Feeney, B. and Pop, C. and Tripathy, A. and Clark, A. C.}, year={2004}, pages={515–525} } @article{chen_clark_2004, title={Kinetic traps in the folding/unfolding of procaspase-1 CARD domain}, volume={13}, ISSN={["1469-896X"]}, DOI={10.1110/ps.03521504}, number={8}, journal={PROTEIN SCIENCE}, author={Chen, YR and Clark, AC}, year={2004}, month={Aug}, pages={2196–2206} } @article{bose_pop_feeney_clark_2003, title={An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3}, volume={42}, ISSN={["0006-2960"]}, DOI={10.1021/bi034998x}, number={42}, journal={BIOCHEMISTRY}, author={Bose, K and Pop, C and Feeney, B and Clark, AC}, year={2003}, month={Oct}, pages={12298–12310} } @article{chen_clark_2003, title={Equilibrium and kinetic folding of a alpha-helical Greek key protein domain: Caspase recruitment domain (CARD) of RICK}, volume={42}, ISSN={["0006-2960"]}, DOI={10.1021/bi0340752}, number={20}, journal={BIOCHEMISTRY}, author={Chen, YR and Clark, AC}, year={2003}, month={May}, pages={6310–6320} } @article{pop_feeney_tripathy_clark_2003, title={Mutations in the procaspase-3 dimer interface affect the activity of the zymogen}, volume={42}, ISSN={["0006-2960"]}, DOI={10.1021/bi034999p}, number={42}, journal={BIOCHEMISTRY}, author={Pop, C and Feeney, B and Tripathy, A and Clark, AC}, year={2003}, month={Oct}, pages={12311–12320} } @article{shen_clark_huber_2003, title={The C-terminal tail of Arabidopsis 14-3-3 omega functions as an autoinhibitor and may contain a tenth alpha-helix}, volume={34}, ISSN={["1365-313X"]}, DOI={10.1046/j.1365-313X.2003.01739.x}, number={4}, journal={PLANT JOURNAL}, author={Shen, W and Clark, AC and Huber, SC}, year={2003}, month={May}, pages={473–484} } @article{bose_clark_2001, title={Dimeric procaspase-3 unfolds via a four-state equilibrium process}, volume={40}, ISSN={["0006-2960"]}, DOI={10.1021/bi0110387}, number={47}, journal={BIOCHEMISTRY}, author={Bose, K and Clark, AC}, year={2001}, month={Nov}, pages={14236–14242} } @article{pop_chen_smith_bose_bobay_tripathy_franzen_clark_2001, title={Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer}, volume={40}, ISSN={["0006-2960"]}, DOI={10.1021/bi011037e}, number={47}, journal={BIOCHEMISTRY}, author={Pop, C and Chen, YR and Smith, B and Bose, K and Bobay, B and Tripathy, A and Franzen, S and Clark, AC}, year={2001}, month={Nov}, pages={14224–14235} } @article{clark_noland_baldwin_2000, title={A rapid chromatographic method to separate the subunits of bacterial luciferase in urea-containing buffer}, volume={305}, journal={Bioluminescence and chemiluminescence, pt. C}, publisher={New York: Academic Press, 1978-}, author={Clark, A. C. and Noland, B. W. and Baldwin, T. O.}, year={2000}, pages={157–164} }