@article{jennings_wise_nickeleit_maes_cianciolo_piero_law_kim_mccalla_breuhaus_et al._2013, title={Polyomavirus-Associated Nephritis in 2 Horses}, volume={50}, ISSN={0300-9858 1544-2217}, url={http://dx.doi.org/10.1177/0300985813476063}, DOI={10.1177/0300985813476063}, abstractNote={ Polyomaviruses produce latent and asymptomatic infections in many species, but productive and lytic infections are rare. In immunocompromised humans, polyomaviruses can cause tubulointerstitial nephritis, demyelination, or meningoencephalitis in the central nervous system and interstitial pneumonia. This report describes 2 Standardbred horses with tubular necrosis and tubulointerstitial nephritis associated with productive equine polyomavirus infection that resembles BK polyomavirus nephropathy in immunocompromised humans. }, number={5}, journal={Veterinary Pathology}, publisher={SAGE Publications}, author={Jennings, S. H. and Wise, A. G. and Nickeleit, V. and Maes, R. K. and Cianciolo, R. E. and Piero, F. Del and Law, J. M. and Kim, Y. and McCalla, A. C. and Breuhaus, B. A. and et al.}, year={2013}, month={Feb}, pages={769–774} }
 @article{stringer_de voe_linder_troan_mccalla-martin_loomis_2012, title={VESICULOBULLOUS SKIN REACTION TEMPORALLY RELATED TO FIROCOXIB TREATMENT IN A WHITE RHINOCEROS (CERATOTHERIUM SIMUM)}, volume={43}, ISSN={["1042-7260"]}, DOI={10.1638/2011-0128.1}, abstractNote={Abstract:  A 40 yr-old female white rhinoceros (Ceratotherium simum) suffered from chronic nail-bed abscesses. Due to worsening of clinical signs, the animal's nonsteroidal anti-inflammatory treatment was switched to firocoxib. Approximately 7 days after this change, the animal developed multifocal vesicles and bullae along the lateral aspects of the thorax and abdomen, the dorsum, and the proximal limbs. Cytology and culture did not identify an infectious etiology. Histologically, the lesions consisted of a severe, subacute vesiculobullous dermatitis with intraepidermal to subepidermal clefting with areas of individual keratinocyte necrosis and minor neutrophilic epidermal infiltrates. These findings are similar to those seen in some drug reactions in people; therefore an adverse drug reaction to the firocoxib was suspected.}, number={1}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Stringer, Elizabeth M. and De Voe, Ryan S. and Linder, Keith and Troan, Brigid and McCalla-Martin, Amy and Loomis, Michael R.}, year={2012}, month={Mar}, pages={186–189} }
 @article{mccalla-martin_chen_linder_estrada_piedrahita_2010, title={Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2ΔN}, volume={19}, ISSN={0962-8819 1573-9368}, url={http://dx.doi.org/10.1007/s11248-010-9362-0}, DOI={10.1007/s11248-010-9362-0}, abstractNote={This study was undertaken to characterize the effects of constitutive expression of the hedgehog transcriptional activator, Gli2, in porcine skin. The keratinocyte-specific human transgene, K5-hGli2 Delta N, was used to produce transgenic porcine lines via somatic cell nuclear transfer techniques. In mice, K5-hGli2 Delta N induces epithelial downgrowths resembling basal cell carcinomas. Our porcine model also developed these basal cell carcinoma-like lesions, however gross tumor development was not appreciated. In contrast to the murine model, diffuse epidermal changes as well as susceptibility to cutaneous infections were seen in the swine model. Histologic analysis of transgenic piglets revealed generalized epidermal changes including: epidermal hyperplasia (acanthosis), elongated rete ridges, parakeratotic hyperkeratosis, epidermal neutrophilic infiltration, capillary loop dilation and hypogranulosis. By 2 weeks of age, the transgenic piglets developed erythematic and edematous lesions at high contact epidermal areas and extensor surfaces of distal limb joints. Despite antibiotic treatment, these lesions progressed to a deep bacterial pyoderma and pigs died or were euthanized within weeks of birth. Non-transgenic littermates were phenotypically normal by gross and histological analysis. In summary, constitutive expression of the human hGli2 Delta N in keratinocytes, results in cutaneous changes that have not been reported in the K5-hGli2 Delta N murine model. These findings indicate a need for a multiple species animal model approach in order to better understand the role of Gli2 in mammalian skin.}, number={5}, journal={Transgenic Research}, publisher={Springer Science and Business Media LLC}, author={McCalla-Martin, Amy C. and Chen, Xiaoxin and Linder, Keith E. and Estrada, Jose L. and Piedrahita, Jorge A.}, year={2010}, month={Jan}, pages={869–887} }
 @article{tsai_mir_martin_estrada_bischoff_hsieh_cassady_freking_nonneman_rohrer_et al._2006, title={Detection of transcriptional difference of porcine imprinted genes using different microarray platforms}, volume={7}, journal={BMC Genomics}, author={Tsai, S. and Mir, B. and Martin, A. C. and Estrada, J. L. and Bischoff, S. R. and Hsieh, W. P. and Cassady, J. P. and Freking, B. A. and Nonneman, D. J. and Rohrer, G. A. and et al.}, year={2006} }