Alexander Deiters

Works (98)

Updated: December 6th, 2023 05:03
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2023 article

Dissection of MKK6 and p38 Signaling Using Light-Activated Protein Kinases

Rahman, S. M. T., Zhou, W., Deiters, A., & Haugh, J. M. (2023, November 7). CHEMBIOCHEM, Vol. 11.

By: S. Rahman, W. Zhou, A. Deiters & J. Haugh 

author keywords: apoptosis; autophagy; cell death; growth factors; mitogen-activated protein kinases; optogenetics; signal transduction
Sources: Web Of Science, ORCID
Added: December 4, 2023

2023 article

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk

Zhou, W., Ryan, A., Janosko, C. P., Shoger, K. E., Haugh, J. M., Gottschalk, R. A., & Deiters, A. (2023, August 25). RSC CHEMICAL BIOLOGY, Vol. 8.

By: W. Zhou, A. Ryan, C. Janosko, K. Shoger, J. Haugh , R. Gottschalk, A. Deiters

Sources: Web Of Science, ORCID
Added: October 2, 2023

2022 article

Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells

Emanuelson, C., Ankenbruck, N., Kumbhare, R., Thomas, M., Connelly, C., Baktash, Y., … Deiters, A. (2022, November 30). JOURNAL OF MEDICINAL CHEMISTRY.

By: C. Emanuelson*, N. Ankenbruck *, R. Kumbhare*, M. Thomas *, C. Connelly  n, Y. Baktash*, G. Randall *, A. Deiters*

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Hepacivirus / genetics; MicroRNAs / metabolism; Hepatitis C / drug therapy; Liver Neoplasms / pathology; Virus Replication
Source: Web Of Science
Added: December 19, 2022

2020 journal article

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

JOURNAL OF BIOLOGICAL CHEMISTRY, 295(25), 8494–8504.

By: S. Rahman n, W. Zhou *, A. Deiters* & J. Haugh n 

co-author countries: United States of America 🇺🇸
author keywords: optogenetics; signal transduction; cell signaling; mitogen-activated protein kinases; apoptosis; cell death; cell stress; mitogen-activated protein kinase (MAPK)
MeSH headings : Animals; Apoptosis / radiation effects; Cell Line; Cell Proliferation / radiation effects; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; Mice; Mitogen-Activated Protein Kinase 1 / metabolism; Mitogen-Activated Protein Kinase 3 / metabolism; Mutagenesis; Protein Isoforms / antagonists & inhibitors; Protein Isoforms / metabolism; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins B-raf / metabolism; Signal Transduction / radiation effects; Ultraviolet Rays; p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors; p38 Mitogen-Activated Protein Kinases / metabolism
Sources: Web Of Science, ORCID
Added: July 27, 2020

2015 journal article

A concise synthesis of the Lycopodium alkaloid cermizine D

TETRAHEDRON LETTERS, 56(23), 3683–3685.

By: M. Enamorado n, C. Connelly n, A. Deiters n & D. Comins n

co-author countries: United States of America 🇺🇸
author keywords: Alkaloid synthesis; Lycopodium alkaloids; Nitrogen heterocycles; 1-Acylpyridinium salts; Asymmetric synthesis
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Conditional Control of Alternative Splicing through Light-Triggered Splice-Switching Oligonucleotides

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 137(10), 3656–3662.

By: J. Hemphill n, Q. Liu n, R. Uprety n, S. Samanta *, M. Tsang *, R. Juliano*, A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alternative Splicing / radiation effects; Animals; HeLa Cells; Humans; Light; Oligonucleotides / chemistry; Oligonucleotides / genetics; Zebrafish
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

CHEMICAL COMMUNICATIONS, 51(26), 5702–5705.

By: K. Brown*, Y. Zou n, D. Shirvanyants*, J. Zhang  n, S. Samanta *, P. Mantravadi*, N. Dokholyan *, A. Deiters*

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Molecular Conformation; Optics and Photonics; Photolysis / radiation effects; Protein Multimerization / radiation effects; Sirolimus / chemistry; Sirolimus / radiation effects; Tacrolimus Binding Protein 1A / chemistry; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Optically triggered immune response through photocaged oligonucleotides

TETRAHEDRON LETTERS, 56(23), 3639–3642.

By: J. Govan n, D. Young n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: Oligonucleotide synthesis; Light-activation; Photocaged nucleotides; Immune response; Toll-like receptors
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Control of Protein Function through Optochemical Translocation

ACS SYNTHETIC BIOLOGY, 3(10), 731–736.

By: H. Engelke *, C. Chou n, R. Uprety n, P. Jess* & A. Deiters n

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
author keywords: protein control; optogenetics; nuclear import; photocontrolled transcription; photocontrolled TEV-cleavage
MeSH headings : Active Transport, Cell Nucleus / radiation effects; Amino Acid Sequence; Endopeptidases / genetics; Endopeptidases / metabolism; Endopeptidases / radiation effects; Forkhead Box Protein O3; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Forkhead Transcription Factors / radiation effects; HEK293 Cells; Humans; Light; Matrix Attachment Region Binding Proteins / genetics; Matrix Attachment Region Binding Proteins / metabolism; Matrix Attachment Region Binding Proteins / radiation effects; Molecular Sequence Data; Nuclear Localization Signals / genetics; Photochemical Processes; Protein Engineering / methods; Synthetic Biology
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genetic Encoding of Caged Cysteine and Caged Homocysteine in Bacterial and Mammalian Cells

CHEMBIOCHEM, 15(12), 1793–1799.

By: R. Uprety n, J. Luo*, J. Liu*, Y. Naro*, S. Samanta * & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: amino acids; caged compounds; cysteine; gene technology; homocysteine; protein modifications
MeSH headings : Cells, Cultured; Cysteine / chemical synthesis; Cysteine / chemistry; Cysteine / genetics; Escherichia coli / cytology; Escherichia coli / genetics; Genetic Code / genetics; HEK293 Cells; Homocysteine / chemical synthesis; Homocysteine / chemistry; Homocysteine / genetics; Humans; Luciferases, Renilla / chemistry; Luciferases, Renilla / metabolism; Models, Molecular; Molecular Structure
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

CHEMICAL COMMUNICATIONS, 50(86), 13085–13088.

By: Y. Lee *, Y. Kurra*, Y. Yang*, J. Torres-Kolbus n, A. Deiters n & W. Liu *

co-author countries: United States of America 🇺🇸
MeSH headings : Alkenes / chemistry; Amino Acids / metabolism; Amino Acyl-tRNA Synthetases / genetics; Amino Acyl-tRNA Synthetases / metabolism; Bacterial Outer Membrane Proteins / chemistry; Bacterial Outer Membrane Proteins / metabolism; Cycloaddition Reaction; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / metabolism; Fluorescein / chemistry; Fluorescent Dyes / chemistry; Green Fluorescent Proteins / chemistry; Heterocyclic Compounds, 1-Ring / chemistry; Hydrolases / chemistry; Hydrolases / metabolism; Mutation; RNA, Transfer / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 article

Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes (vol 50, pg 13085, 2014)

Lee, Y.-J., Kurra, Y., Yang, Y., Torres-Kolbus, J., Deiters, A., & Liu, W. R. (2014, November 11). CHEMICAL COMMUNICATIONS, Vol. 50, pp. 13396–13396.

By: Y. Lee *, Y. Kurra*, Y. Yang*, J. Torres-Kolbus n, A. Deiters n & W. Liu

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Intracellular Light-Activation of Riboswitch Activity

ChemBioChem, 15(9), 1346–1351.

By: S. Walsh n, L. Gardner n, A. Deiters n & G. Williams n 

co-author countries: United States of America 🇺🇸
author keywords: chemical biology; photocontrol; riboswitches; RNA; synthetic biology
MeSH headings : Cell Membrane Permeability; Gene Expression Regulation / drug effects; Gene Expression Regulation / radiation effects; Intracellular Space / drug effects; Intracellular Space / genetics; Intracellular Space / radiation effects; Ligands; Molecular Structure; Riboswitch / drug effects; Riboswitch / genetics; Riboswitch / radiation effects; Structure-Activity Relationship; Theophylline / chemistry; Theophylline / pharmacology; Ultraviolet Rays
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2014 journal article

MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons

CELL REPORTS, 7(4), 1168–1183.

By: M. Volvert*, P. Prevot*, P. Close *, S. Laguesse*, S. Pirotte*, J. Hemphill n, F. Rogister*, N. Kruzy* ...

co-author countries: Belgium 🇧🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Animals; Cell Movement / physiology; Cell Polarity / physiology; Cells, Cultured; Cerebral Cortex / cytology; Co-Repressor Proteins; Mice; Mice, Transgenic; MicroRNAs / metabolism; Nerve Tissue Proteins / metabolism; Neurons / cytology; Neurons / metabolism; Repressor Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 review

Optochemical Control of Deoxyoligonucleotide Function via a Nucleobase-Caging Approach

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 47(1), 45–55.

By: Q. Liu n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Base Sequence; DNA, Catalytic / genetics; DNA, Catalytic / metabolism; Humans; Light; Oligonucleotides / chemistry; Oligonucleotides / metabolism; Photochemical Processes; Proteins / metabolism; RNA / chemistry; RNA / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Site-Specific Promoter Caging Enables Optochemical Gene Activation in Cells and Animals

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(19), 7152–7158.

By: J. Hemphill n, J. Govan n, R. Uprety  n, M. Tsang & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Base Sequence; DNA, Circular / chemistry; DNA, Circular / genetics; Green Fluorescent Proteins / genetics; HEK293 Cells; Humans; Molecular Sequence Data; Photolysis; Plasmids / chemistry; Plasmids / genetics; Promoter Regions, Genetic; Protein Serine-Threonine Kinases / genetics; Transcriptional Activation; Tumor Suppressor Proteins; Ultraviolet Rays; Zebrafish
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Synthesis of Non-linear Protein Dimers through a Genetically Encoded Thiol-ene Reaction

PLOS ONE, 9(9).

By: J. Torres-Kolbus n, C. Chou n, J. Liu* & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alkenes / metabolism; Animals; Fluorescent Dyes / metabolism; Green Fluorescent Proteins / metabolism; Lysine / metabolism; Methanosarcina barkeri / metabolism; Muramidase / metabolism; Myoglobin / metabolism; Protein Multimerization; Sulfhydryl Compounds / metabolism
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Thiourea-Based Fluorescent Chemosensors for Aqueous Metal Ion Detection and Cellular Imaging

JOURNAL OF ORGANIC CHEMISTRY, 79(13), 6054–6060.

By: M. Vonlanthen *, C. Connelly n, A. Deiters n, A. Linden * & N. Finney n

co-author countries: Switzerland 🇨🇭 United States of America 🇺🇸
MeSH headings : Fluorescent Dyes / chemistry; HeLa Cells; Humans; Ions / chemistry; Mercury / analysis; Mercury / chemistry; Metals / analysis; Metals / chemistry; Molecular Imaging; Spectrometry, Fluorescence; Thiourea / chemistry; Water / chemistry
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Two Rapid Catalyst-Free Click Reactions for In Vivo Protein Labeling of Genetically Encoded Strained Alkene/Alkyne Functionalities

BIOCONJUGATE CHEMISTRY, 25(9), 1730–1738.

By: Y. Kurra*, K. Odoi*, Y. Lee *, Y. Yang*, T. Lu*, S. Wheeler *, J. Torres-Kolbus n, A. Deiters n, W. Liu *

co-author countries: United States of America 🇺🇸
MeSH headings : Alkenes / chemistry; Alkynes / chemistry; Catalysis; Click Chemistry; Cyclooctanes / chemistry; Escherichia coli Proteins / chemistry; Kinetics; Models, Molecular; Protein Conformation; Proteins / chemistry; Staining and Labeling / methods; Tyrosine / chemistry
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Cellular Delivery and Photochemical Activation of Antisense Agents through a Nucleobase Caging Strategy

ACS CHEMICAL BIOLOGY, 8(10), 2272–2282.

By: J. Govan n, R. Uprety n, M. Thomas  n, H. Lusic n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Base Sequence; Gene Transfer Techniques; HeLa Cells; Humans; Light; Models, Biological; Molecular Structure; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / metabolism; Polymerase Chain Reaction; tat Gene Products, Human Immunodeficiency Virus / chemistry; tat Gene Products, Human Immunodeficiency Virus / genetics
Source: Web Of Science
Added: August 6, 2018

2013 journal article

DNA Computation in Mammalian Cells: MicroRNA Logic Operations

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 135(28), 10512–10518.

By: J. Hemphill n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Computers, Molecular; DNA / chemistry; DNA / metabolism; HeLa Cells; Humans; MicroRNAs / chemistry; MicroRNAs / metabolism; Photochemical Processes
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Genetically encoded light-activated transcription for spatiotemporal control of gene expression and gene silencing in mammalian cells

Journal of the American Chemical Society, 135(36), 13433–13439.

By: J. Hemphill n, C. Chou n, J. Chin * & A. Deiters n

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Activating Transcription Factors / genetics; Activating Transcription Factors / metabolism; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Gene Expression Regulation, Enzymologic / genetics; Gene Silencing; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; HEK293 Cells; Humans; Light; Luciferases / genetics; Luciferases / metabolism; Models, Molecular; Molecular Structure; Photochemical Processes; Protein Engineering; Viral Proteins / genetics; Viral Proteins / metabolism
Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

MicroRNA miR-122 as a therapeutic target for oligonucleotides and small molecules

Current Medicinal Chemistry, 20(29), 3629–3640.

By: M. Thomas & A. Deiters*

MeSH headings : Animals; Hepacivirus / drug effects; Hepacivirus / genetics; Hepacivirus / physiology; Humans; Liver Diseases / drug therapy; Liver Diseases / genetics; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; Molecular Targeted Therapy / methods; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / therapeutic use; Small Molecule Libraries / pharmacology; Small Molecule Libraries / therapeutic use
Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Optochemical control of RNA interference in mammalian cells

NUCLEIC ACIDS RESEARCH, 41(22), 10518–10528.

By: J. Govan n, D. Young  n, H. Lusic n, Q. Liu  n, M. Lively n & A. Deiters n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2012 journal article

DNA Computation: A Photochemically Controlled AND Gate

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(8), 3810–3815.

By: A. Prokup n, J. Hemphill n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Base Sequence; Computers, Molecular; DNA / chemistry; Logic; Photochemistry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

NATURE CHEMISTRY, 4(4), 298–304.

By: K. Lang *, L. Davis*, J. Torres-Kolbus n, C. Chou n, A. Deiters n & J. Chin *

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Amino Acids / metabolism; Amino Acyl-tRNA Synthetases / metabolism; Cell Line; Fluorescent Dyes / chemistry; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; Lysine / analogs & derivatives; Lysine / metabolism; Norbornanes / chemistry; Proteins / genetics; Proteins / metabolism; Rhodamines / chemistry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

High-Throughput Luciferase Reporter Assay for Small-Molecule Inhibitors of MicroRNA Function

JOURNAL OF BIOMOLECULAR SCREENING, 17(6), 822–828.

By: C. Connelly n, M. Thomas  n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: high-throughput assay; cell-based assay; luciferase; microRNA; small-molecule inhibitor
MeSH headings : Antineoplastic Agents / pharmacology; Antiviral Agents / pharmacology; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line, Tumor; Gene Expression; Genes, Reporter; Hepacivirus / metabolism; Hepatitis C / genetics; Hepatitis C / metabolism; High-Throughput Screening Assays / methods; Humans; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; Luciferases, Renilla / genetics; Luciferases, Renilla / metabolism; MicroRNAs / antagonists & inhibitors; MicroRNAs / metabolism; Oligonucleotides, Antisense; Small Molecule Libraries / pharmacology; Transfection
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(36), 9066–9070.

By: J. Govan n, A. McIver n, C. Riggsbee n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: biosensors; estrogen receptor; estrone; gene expression; hydrogen peroxide
Source: Web Of Science
Added: August 6, 2018

2012 review

Light-controlled synthetic gene circuits

[Review of ]. CURRENT OPINION IN CHEMICAL BIOLOGY, 16(3-4), 292–299.

By: L. Gardner n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Line; Gene Regulatory Networks / drug effects; Gene Regulatory Networks / radiation effects; Genetic Engineering / methods; Humans; Light; Photochemical Processes
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 134(29), 11912–11915.

By: E. Arbely *, J. Torres-Kolbus n, A. Deiters n & J. Chin *

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Amino Acyl-tRNA Synthetases / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; HEK293 Cells; Humans; Light; Methanosarcina / enzymology; Methanosarcina / genetics; Mutation; Phosphorylation; Protein Engineering / methods; STAT1 Transcription Factor / genetics; STAT1 Transcription Factor / metabolism; Signal Transduction; Tyrosine / genetics; Tyrosine / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Regulation of transcription through light-activation and light-deactivation of triplex-forming oligonucleotides in mammalian cells

ACS Chemical Biology, 7(7), 1247–1256.

By: J. Govan n, R. Uprety n, J. Hemphill n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : DNA / chemistry; DNA / metabolism; HEK293 Cells; Humans; Nucleic Acid Conformation; Oligonucleotides / chemistry; Oligonucleotides / metabolism; Photic Stimulation / methods; Transcription, Genetic / physiology
Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Spatiotemporal control of microRNA function using light-activated antagomirs

MOLECULAR BIOSYSTEMS, 8(11), 2987–2993.

By: C. Connelly n, R. Uprety n, J. Hemphill n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Antagomirs; Apoptosis / drug effects; Apoptosis / radiation effects; Cell Differentiation / drug effects; Cell Differentiation / radiation effects; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Proliferation / radiation effects; Humans; Light; MicroRNAs / antagonists & inhibitors; MicroRNAs / metabolism; MicroRNAs / radiation effects; Oligonucleotides / chemistry; Oligonucleotides / pharmacology; Oligonucleotides / radiation effects; Photochemistry; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2011 journal article

A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos

Development, 139(2), 437–442.

By: A. Morckel n, H. Lusic n, L. Farzana n, J. Yoder n , A. Deiters n & N. Nascone-Yoder n

co-author countries: United States of America 🇺🇸
author keywords: Small-molecule inhibitor; Rho kinase; Photocaging; Xenopus
MeSH headings : Animals; Body Patterning / drug effects; Dioxoles / metabolism; Dioxoles / pharmacology; Embryo, Nonmammalian / metabolism; Immunohistochemistry; Indoles / metabolism; Indoles / pharmacology; Mice; NIH 3T3 Cells; Pyridines / metabolism; Pyridines / pharmacology; Ultraviolet Rays; Xenopus laevis / embryology; Xenopus laevis / metabolism; rho-Associated Kinases / antagonists & inhibitors; rho-Associated Kinases / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2011 journal article

Efficacy of C-N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011(22), 4154–4159.

By: Y. Zou n, H. Lin n, P. Maggard n  & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: Reaction mechanisms; Nitrogen heterocycles; C-N coupling; Cross-coupling; Arylation; Copper; Homogeneous catalysis
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Genetically encoding an aliphatic diazirine for protein photocrosslinking

CHEMICAL SCIENCE, 2(3), 480–483.

By: C. Chou n, R. Uprety n, L. Davis*, J. Chin * & A. Deiters n

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(3), 420–423.

By: A. Karginov  n, Y. Zou n, D. Shirvanyants n, P. Kota  n, N. Dokholyan  n, D. Young n, K. Hahn  n, A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Dimerization; Focal Adhesion Protein-Tyrosine Kinases / metabolism; HEK293 Cells; Humans; Light; Models, Molecular; Molecular Dynamics Simulation; Sirolimus / chemistry; Tacrolimus Binding Proteins / chemistry; Tacrolimus Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Light-Activated Gene Editing with a Photocaged Zinc-Finger Nuclease

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 50(30), 6839–6842.

By: C. Chou n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: caged compounds; gene technology; light-activation; mutagenesis; zinc-finger nucleases
MeSH headings : Endonucleases / genetics; Endonucleases / metabolism; Escherichia coli / genetics; HEK293 Cells; Humans; Models, Molecular; Mutagenesis; Photochemical Processes; Protein Engineering; Tyrosine / genetics; Ultraviolet Rays; Zinc Fingers
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(7), 2124–2127.

By: A. Gautier *, A. Deiters n & J. Chin *

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Animals; Catalytic Domain; Humans; Light; Mitogen-Activated Protein Kinase Kinases / chemistry; Mitogen-Activated Protein Kinase Kinases / pharmacology; Models, Molecular; Phosphorylation; Phosphotransferases / chemistry; Phosphotransferases / pharmacology; Signal Transduction / drug effects
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Photochemical Control of DNA Decoy Function Enables Precise Regulation of Nuclear Factor kappa B Activity

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(33), 13176–13182.

By: J. Govan n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaline Phosphatase / genetics; Gene Expression Regulation / radiation effects; Light; Methods; NF-kappa B / metabolism; Oligodeoxyribonucleotides / radiation effects; Photochemical Processes; Transcription, Genetic / drug effects
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Photochemical control of bacterial signal processing using a light-activated erythromycin

MOLECULAR BIOSYSTEMS, 7(9), 2554–2557.

By: L. Gardner n, Y. Zou n, A. Mara n, T. Cropp * & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Erythromycin / pharmacology; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli / radiation effects; Exoribonucleases / genetics; Exoribonucleases / metabolism; Light; Photochemistry / methods
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Stabilization and Photochemical Regulation of Antisense Agents through PEGylation

BIOCONJUGATE CHEMISTRY, 22(10), 2136–2142.

By: J. Govan n, A. McIver n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; DNA, Antisense / chemical synthesis; DNA, Antisense / chemistry; DNA, Antisense / genetics; DNA, Antisense / metabolism; Gene Expression Regulation; HEK293 Cells; Humans; Luminescent Proteins / genetics; Mice; NIH 3T3 Cells; Nucleic Acid Denaturation; Photolysis; Polyethylene Glycols / chemistry; Ribonuclease H / metabolism; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Synthesis of the Pyridine Core of Cyclothiazomycin

ORGANIC LETTERS, 13(16), 4352–4355.

By: Y. Zou n, Q. Liu  n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Molecular Structure; Peptides, Cyclic / chemistry; Pyridines / chemical synthesis; Thiazoles / chemistry
Source: Web Of Science
Added: August 6, 2018

2011 journal article

The Human Mitochondrial tRNA(Met): Structure/Function Relationship of a Unique Modification in the Decoding of Unconventional Codons

JOURNAL OF MOLECULAR BIOLOGY, 406(2), 257–274.

By: Y. Bilbille n, E. Gustilo n, K. Harris  n, C. Jones*, H. Lusic n, R. Kaiser*, M. Delano, L. Spremulli*, A. Deiters n, P. Agris  n

co-author countries: United States of America 🇺🇸
author keywords: 5-formylcytidine; NMR structure; mitochondrial translation; codon expansion; near cognate decoding
MeSH headings : Animals; Anticodon / chemistry; Anticodon / genetics; Base Pairing; Base Sequence; Cattle; Cytidine / analogs & derivatives; Cytidine / chemistry; Cytidine / genetics; Escherichia coli / genetics; Humans; Mitochondria / chemistry; Mitochondria / genetics; Molecular Sequence Data; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / genetics; Ribosomes / chemistry; Ribosomes / genetics; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(17), 6183–6193.

By: D. Young n, M. Lively n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Base Sequence; Cell Line; DNA / chemistry; DNA / metabolism; DNA, Catalytic / metabolism; DNA, Catalytic / radiation effects; Enzyme Activation; Gene Expression / radiation effects; Gene Expression Regulation; Humans; Light; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides, Antisense / metabolism; Oligodeoxyribonucleotides, Antisense / radiation effects; Photochemical Processes; RNA / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(42), 14819–14824.

By: S. Hancock n, R. Uprety n, A. Deiters n & J. Chin  n

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Amino Acids / metabolism; Amino Acyl-tRNA Synthetases / metabolism; Genetic Code; RNA, Fungal / metabolism; RNA, Transfer / metabolism; Saccharomyces cerevisiae / enzymology; Saccharomyces cerevisiae / genetics
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Generating Permissive Site-Specific Unnatural Aminoacyl-tRNA Synthetases

BIOCHEMISTRY, 49(8), 1667–1677.

By: S. Miyake-Stoner *, C. Refakis*, J. Hammill *, H. Lusic n, J. Hazen*, A. Deiters n, R. Mehl *

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acids / chemistry; Amino Acids / metabolism; Amino Acyl-tRNA Synthetases / chemistry; Amino Acyl-tRNA Synthetases / genetics; Amino Acyl-tRNA Synthetases / metabolism; Fluorine / chemistry; Green Fluorescent Proteins / chemistry; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Protein Engineering; Substrate Specificity
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Genetically encoded photocontrol of protein localization in mammalian cells

Journal of the American Chemical Society, 132(12), 4086-.

By: A. Gautier, D. Nguyen, H. Lusic, W. An, A. Deiters & J. Chin

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Improved Synthesis of the Two-Photon Caging Group 3-Nitro-2-Ethyldibenzofuran and Its Application to a Caged Thymidine Phosphoramidite

ORGANIC LETTERS, 12(5), 916–919.

By: H. Lusic n, R. Uprety n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Benzofurans / chemical synthesis; Benzofurans / chemistry; DNA / chemical synthesis; DNA / chemistry; Organophosphorus Compounds / chemistry; Photons; Thymidine Monophosphate / analogs & derivatives; Thymidine Monophosphate / chemistry
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos

Journal of the American Chemical Society, 132(44), 15644–15650.

By: A. Deiters n, R. Garner n, H. Lusic n, J. Govan n, M. Dush n, N. Nascone-Yoder n, J. Yoder n 

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cells, Cultured; Embryo, Nonmammalian / metabolism; Gene Expression; Morpholines / chemistry; Oligonucleotides / genetics; Oligonucleotides / metabolism; Ultraviolet Rays; Xenopus laevis / genetics; Xenopus laevis / metabolism; Zebrafish / genetics; Zebrafish / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2010 journal article

Photocaged T7 RNA Polymerase for the Light Activation of Transcription and Gene Function in Pro- and Eukaryotic Cells

CHEMBIOCHEM, 11(7), 972–977.

By: C. Chou n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: amino acids; caged proteins; light activation; polymerases; RNA
MeSH headings : Catalytic Domain; Cell Line; DNA-Directed RNA Polymerases / genetics; DNA-Directed RNA Polymerases / metabolism; Escherichia coli / enzymology; Humans; Luciferases / genetics; Luciferases / metabolism; Models, Molecular; Photochemical Processes; Transcriptional Activation; Tyrosine / chemistry; Ultraviolet Rays; Viral Proteins / genetics; Viral Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function

BIOCONJUGATE CHEMISTRY, 21(8), 1404–1407.

By: W. Georgianna n, H. Lusic n, A. Mclver & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Crystallography, X-Ray; Models, Molecular; Molecular Structure; Muramidase / chemistry; Muramidase / metabolism; Photochemical Processes; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Stereoisomerism; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Principles and Applications of the Photochemical Control of Cellular Processes

CHEMBIOCHEM, 11(1), 47–53.

By: A. Deiters*

author keywords: biological activity; cage compounds; chemical biology; light regulation; photochemistry
MeSH headings : Animals; Biological Phenomena / radiation effects; DNA / chemistry; Doxycycline / chemistry; Embryo, Mammalian; Mice; Phosphorothioate Oligonucleotides / chemistry; Photochemical Processes; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2010 review

Recent advances in the photochemical control of protein function

[Review of ]. TRENDS IN BIOTECHNOLOGY, 28(9), 468–475.

By: C. Riggsbee n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Biotechnology / methods; Cell Line; Humans; Ion Channels / chemistry; Ion Channels / genetics; Ion Channels / physiology; Light; Models, Molecular; Photochemical Processes; Photochemistry / methods; Proteins / chemistry; Proteins / genetics; Proteins / physiology
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Reversible light switching of cell signalling by genetically encoded protein dimerization

Chembiochem, 11(3), 301–303.

By: W. Georgianna n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Cell Membrane / chemistry; Cell Membrane / metabolism; Light; Luminescent Proteins / chemistry; Luminescent Proteins / metabolism; Mice; NIH 3T3 Cells; Phycobilins / chemistry; Phycocyanin / chemistry; Phytochrome B / chemistry; Phytochrome B / genetics; Phytochrome B / metabolism; Protein Multimerization; Protein Structure, Tertiary; Signal Transduction
Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Site-Specific Incorporation of Fluorotyrosines into Proteins in Escherichia coli by Photochemical Disguise

BIOCHEMISTRY, 49(8), 1557–1559.

By: B. Wilkins*, S. Marionni*, D. Young n, J. Liu *, Y. Wang, M. Di Salvo *, A. Deiters n, T. Cropp *

co-author countries: Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Molecular Structure; Protein Engineering / methods; Protein Structure, Secondary; Tyrosine / analogs & derivatives; Tyrosine / chemical synthesis; Tyrosine / chemistry; Tyrosine / metabolism
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 132(23), 7976–7981.

By: D. Young n, C. Connelly n, C. Grohmann n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Apoptosis / drug effects; Base Sequence; Carcinoma, Hepatocellular / drug therapy; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / pathology; Enoxacin / pharmacology; HeLa Cells; Hepatitis C / drug therapy; Hepatitis C / genetics; Humans; Liver Neoplasms / drug therapy; Liver Neoplasms / genetics; Liver Neoplasms / pathology; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; MicroRNAs / metabolism; Oligonucleotides, Antisense / genetics; Oligonucleotides, Antisense / pharmacology; Virus Replication / drug effects; Virus Replication / genetics
Source: Web Of Science
Added: August 6, 2018

2010 review

Small Molecule Modifiers of the microRNA and RNA Interference Pathway

[Review of ]. AAPS JOURNAL, 12(1), 51–60.

By: A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: cancer; microRNA; RNA; RNA interference; small molecule
MeSH headings : Animals; Humans; MicroRNAs / antagonists & inhibitors; MicroRNAs / biosynthesis; RNA Interference / drug effects; RNA, Small Interfering / biosynthesis
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Total Synthesis of Cryptoacetalide

JOURNAL OF ORGANIC CHEMISTRY, 75(15), 5355–5358.

By: Y. Zou n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Chromatography, High Pressure Liquid; Diterpenes / chemical synthesis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization-Coupled Intramolecular Nucleophilic Substitution Reaction

ORGANIC LETTERS, 12(6), 1288–1291.

By: A. McIver n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Cyclization; Microwaves; Molecular Structure; Pyridines / chemistry; Stereoisomerism
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A Light-Activated DNA Polymerase

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 48(32), 5950–5953.

By: C. Chou n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: DNA polymerases; mutagenesis; non-natural amino acids; photoactivation; polymerase chain reaction
MeSH headings : Catalytic Domain; Mutation; Nitrobenzenes / chemistry; Photolysis; Polymerase Chain Reaction; Taq Polymerase / chemistry; Taq Polymerase / metabolism; Tyrosine / chemistry; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC-FTICR Mass Spectrometry

JOURNAL OF PROTEOME RESEARCH, 8(7), 3764–3770.

By: M. Bereman n, D. Young n, A. Deiters n & D. Muddiman n 

co-author countries: United States of America 🇺🇸
MeSH headings : Biomarkers, Tumor / metabolism; Blood Proteins / chemistry; Chromatography, Liquid / methods; Detergents / pharmacology; Glycoproteins / chemistry; Humans; Mass Spectrometry / methods; Microwaves; Peptides / chemistry; Polysaccharides / chemistry; Proteome; Proteomics / methods; Spectroscopy, Fourier Transform Infrared / methods; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Genetic Encoding and Labeling of Aliphatic Azides and Alkynes in Recombinant Proteins via a Pyrrolysyl-tRNA Synthetase/tRNA(CUA) Pair and Click Chemistry

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(25), 8720-+.

By: D. Nguyen  n, H. Lusic n, H. Neumann  n, P. Kapadnis n, A. Deiters n & J. Chin  n

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
MeSH headings : Alkynes / chemistry; Alkynes / metabolism; Amino Acyl-tRNA Synthetases / genetics; Amino Acyl-tRNA Synthetases / metabolism; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Azides / chemistry; Azides / metabolism; Escherichia coli / genetics; Escherichia coli Proteins / chemistry; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Lysine / chemistry; Lysine / genetics; Lysine / metabolism; Methanosarcina barkeri / enzymology; Myoglobin / chemistry; Myoglobin / genetics; Myoglobin / metabolism; Protein Engineering / methods; Recombinant Proteins / chemistry; Recombinant Proteins / genetics; Recombinant Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2009 review

Light activation as a method of regulating and studying gene expression

[Review of ]. CURRENT OPINION IN CHEMICAL BIOLOGY, 13(5-6), 678–686.

By: A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Gene Expression Regulation / drug effects; Gene Expression Regulation / radiation effects; Humans; Light; Oligonucleotides / genetics; Oligonucleotides / metabolism; Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells

ACS CHEMICAL BIOLOGY, 4(6), 441–445.

By: W. Edwards n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Binding Sites; Biocatalysis / radiation effects; Cells, Cultured; Cloning, Molecular; DNA / chemistry; DNA / metabolism; Genetic Engineering / methods; Humans; Integrases / chemistry; Integrases / metabolism; Models, Molecular; Nitrobenzenes / chemistry; Nitrobenzenes / pharmacology; Recombination, Genetic / radiation effects; Time Factors; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Light-activation of gene function in mammalian cells via ribozymes

Chem. Commun., (5), 568–570.

By: D. Young n, R. Garner n, J. Yoder n  & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Line; Gene Expression / radiation effects; Humans; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; RNA, Messenger / metabolism; Toyocamycin / chemistry; Toyocamycin / radiation effects; Ultraviolet Rays
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2009 journal article

Open-Vessel Microwave-Mediated [2+2+2]-Cyclotrimerization Reactions

SYNTHESIS-STUTTGART, (22), 3785–3790.

By: D. Young*, J. Teske* & A. Deiters*

author keywords: [2+2+2] cyclotrimerization; alkynes; microwave; bicyclic compounds; transition metal catalysis
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Photochemical Regulation of Restriction Endonuclease Activity

CHEMBIOCHEM, 10(10), 1612–1616.

By: D. Young n, J. Govan n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: cage compounds; DNA cleavage; DNA enzymes; photochemistry
MeSH headings : Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Benzodioxoles / chemistry; DNA / chemistry; DNA / radiation effects; DNA Cleavage; DNA Restriction Enzymes / genetics; DNA Restriction Enzymes / metabolism; Deoxyribonuclease BamHI / genetics; Deoxyribonuclease BamHI / metabolism; Deoxyribonuclease EcoRI / genetics; Deoxyribonuclease EcoRI / metabolism; Deoxyribonucleases, Type II Site-Specific / genetics; Deoxyribonucleases, Type II Site-Specific / metabolism; Substrate Specificity; Thymidine / analogs & derivatives; Thymidine / chemistry; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization

Nucleic Acids Research, 37(8).

By: D. Young, H. Lusic, M. Lively & A. Deiters

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

The effect of microwave irradiation on DNA hybridization

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(12), 2506–2508.

By: W. Edwards n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Base Sequence; DNA / chemistry; DNA / genetics; DNA / radiation effects; Microwaves; Nucleic Acid Denaturation / radiation effects; Nucleic Acid Hybridization / radiation effects; Spectrometry, Fluorescence; Transition Temperature
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A cyclotrimerization route to cannabinoids

ORGANIC LETTERS, 10(11), 2195–2198.

By: J. Teske n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alkynes / chemistry; Cannabinoids / chemical synthesis; Cannabinoids / chemistry; Cyclization; Nitriles / chemistry
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine

CHEMICAL COMMUNICATIONS, (39), 4750–4752.

By: A. McIver n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / radiation effects; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Aza Compounds / radiation effects; Chrysenes / chemical synthesis; Chrysenes / chemistry; Chrysenes / radiation effects; Cyclization; Indolizines / chemical synthesis; Indolizines / chemistry; Indolizines / radiation effects; Microwaves; Molecular Structure; Phenanthrenes / chemical synthesis; Phenanthrenes / chemistry; Phenanthrenes / radiation effects; Stereoisomerism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents

ChemBioChem, 9(18), 2937–2940.

By: D. Young n, H. Lusic n, M. Lively*, J. Yoder n  & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: Antisense agents; caged compounds; DNA; gene regulation; RNA
MeSH headings : Animals; Base Sequence; Gene Silencing; Genes, Reporter; Light; Luciferases, Renilla / chemistry; Mice; NIH 3T3 Cells; Oligonucleotides, Antisense / chemistry; Oligonucleotides, Antisense / metabolism; Oligonucleotides, Antisense / radiation effects; Phosphorothioate Oligonucleotides / chemistry; Phosphorothioate Oligonucleotides / metabolism; Transfection
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2008 journal article

Light-activated deoxyguanosine: photochemical regulation of peroxidase activity

MOLECULAR BIOSYSTEMS, 4(6), 508–511.

By: H. Lusic n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Biocatalysis / radiation effects; DNA, Catalytic / chemical synthesis; DNA, Catalytic / chemistry; DNA, Catalytic / radiation effects; Deoxyguanosine / chemical synthesis; Deoxyguanosine / chemistry; Deoxyguanosine / metabolism; Enzyme Activation / radiation effects; Molecular Structure; Organophosphorus Compounds / chemical synthesis; Organophosphorus Compounds / chemistry; Organophosphorus Compounds / metabolism; Peroxidase / metabolism; Photochemistry; Time Factors; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Light-regulated RNA-small molecule interactions

CHEMBIOCHEM, 9(8), 1225–1228.

By: D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: aptamer; light; riboswitch; RNA; spiropyran
MeSH headings : Aptamers, Nucleotide / chemistry; Aptamers, Nucleotide / isolation & purification; Benzopyrans / chemistry; Indoles / chemistry; Light; Molecular Structure; Nitro Compounds / chemistry; Photochemistry; Pyrimidinones / chemistry; RNA / chemistry; Substrate Specificity; Surface Plasmon Resonance
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Light-triggered polymerase chain reaction

CHEMICAL COMMUNICATIONS, (4), 462–464.

By: D. Young n, W. Edwards n, H. Lusic n, M. Lively* & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Base Sequence; DNA / chemistry; DNA Primers; Light; Photochemistry; Polymerase Chain Reaction / methods
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Microwave activation of enzymatic catalysis

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(31), 10048-+.

By: D. Young n, J. Nichols n, R. Kelly n  & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Carboxylesterase / metabolism; Catalysis; Enzymes / metabolism; Hot Temperature; Kinetics; Microwaves; Pyrococcus furiosus / enzymology; Sulfolobus solfataricus / enzymology; Thermotoga maritima / enzymology; alpha-Galactosidase / metabolism; beta-Glucosidase / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Microwave-assisted synthesis of unnatural amino acids

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(20), 5478–5480.

By: D. Young n, J. Torres-Kolbus n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: microwave; microwave synthesis; amino acid; unnatural amino acid; peptide synthesis; protein synthesis; unnatural amino acid; mutagenesis
MeSH headings : Amino Acids / chemical synthesis; Chemistry, Pharmaceutical / methods; Drug Design; Magnetic Resonance Spectroscopy; Microwaves; Models, Chemical; Mutagenesis; Peptides / chemistry; Proteins / chemistry; Temperature
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Microwave-mediated Nickel-catalyzed cyclotrimerization reactions: Total synthesis of illudinine

JOURNAL OF ORGANIC CHEMISTRY, 73(1), 342–345.

By: J. Teske n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Catalysis; Cyclization; Microwaves; Molecular Structure; Nickel / chemistry; Nickel / radiation effects; Organometallic Compounds / chemistry; Organometallic Compounds / radiation effects; Sesquiterpenes / chemical synthesis; Sesquiterpenes / chemistry; Sesquiterpenes / radiation effects; Stereoisomerism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Phenanthridine synthesis via [2+2+2] cyclotrimerization reactions

ORGANIC & BIOMOLECULAR CHEMISTRY, 6(2), 263–265.

By: L. Sripada n, J. Teske n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Cyclization; Microwaves; Molecular Structure; Phenanthridines / chemical synthesis; Phenanthridines / chemistry; Phenanthridines / radiation effects; Stereoisomerism
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Small-molecule inhibitors of microRNA miR-21 function

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(39), 7482–7484.

By: K. Gumireddy*, D. Young n, X. Xiong  n, J. Hogenesch *, Q. Huang * & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: antitumor agents; cell-based assays; inhibitors; medicinal chemistry; microRNA
MeSH headings : Gene Expression; Genes, Reporter / genetics; HeLa Cells; Humans; MicroRNAs / antagonists & inhibitors; MicroRNAs / genetics; Molecular Structure
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNA(Met)

NUCLEIC ACIDS RESEARCH, 36(20), 6548–6557.

By: H. Lusic n, E. Gustilo n, F. Vendeix n, R. Kaiser n, M. Delaney n, W. Graham n, V. Moye n, W. Cantara n, P. Agris n, A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Anticodon / chemistry; Base Sequence; Codon / metabolism; Cytidine / analogs & derivatives; Cytidine / chemistry; Humans; Molecular Sequence Data; Nucleic Acid Conformation; Protein Biosynthesis; RNA / chemistry; RNA, Mitochondrial; RNA, Transfer, Met / chemical synthesis; RNA, Transfer, Met / chemistry; RNA, Transfer, Met / metabolism; Thermodynamics
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions

ORGANIC LETTERS, 10(20), 4661–4664.

By: Y. Zou n, D. Young n, A. Cruz-Montanez n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Anthracenes / chemical synthesis; Anthracenes / chemistry; Aza Compounds / chemical synthesis; Aza Compounds / chemistry; Benzene / chemistry; Cell Line; Cyclization; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Molecular Structure; Pyridines / chemistry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A general approach to chemo- and regioselective cyclotrimerization reactions

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(27), 5187–5190.

By: D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: cycloaddition; heterocycles; microwave synthesis; solid-phase synthesis; transition metals
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Microwave-assisted solid-supported alkyne cyclotrimerization reactions for combinatorial chemistry

JOURNAL OF COMBINATORIAL CHEMISTRY, 9(5), 735–738.

By: D. Young n, L. Sripada n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Alkynes / chemistry; Combinatorial Chemistry Techniques; Cyclization; Microwaves
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Photochemical DNA activation

ORGANIC LETTERS, 9(10), 1903–1906.

By: H. Lusic n, D. Young n, M. Lively n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : DNA, Catalytic / chemistry; DNA, Catalytic / metabolism; Molecular Sequence Data; Molecular Structure; Photochemistry; RNA / metabolism; Substrate Specificity
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Photochemical activation of protein expression in bacterial cells

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 46(23), 4290–4292.

By: D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: bacterial cells; caged compounds; gene expression; photochemistry; proteins
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Photochemical control of biological processes

ORGANIC & BIOMOLECULAR CHEMISTRY, 5(7), 999–1005.

By: D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
MeSH headings : Enzymes / genetics; Enzymes / radiation effects; Humans; Light; Molecular Conformation; Organic Chemicals / chemistry; Organic Chemicals / radiation effects; Photochemistry; Proteins / genetics; Proteins / radiation effects; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Synthesis of indanones via solid-supported [2+2+2] cyclotrimerization

JOURNAL OF ORGANIC CHEMISTRY, 72(20), 7801–7804.

By: R. Senaiar n, J. Teske n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A genetically encoded fluorescent amino acid

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(26), 9785–9789.

By: D. Summerer *, S. Chen *, N. Wu *, A. Deiters n, J. Chin * & P. Schultz *

co-author countries: United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
author keywords: molecular evolution; fluorescent probes; genetic code expansion; protein design; unnatural amino acids
MeSH headings : Alanine / analogs & derivatives; Alanine / chemistry; Alanine / genetics; Alanine / metabolism; Amino Acids / chemistry; Amino Acids / genetics; Amino Acids / metabolism; Amino Acyl-tRNA Synthetases / genetics; Amino Acyl-tRNA Synthetases / metabolism; Codon, Nonsense / metabolism; Dansyl Compounds / chemistry; Dansyl Compounds / metabolism; Fluorescent Dyes / chemistry; Genetic Code; Humans; RNA, Transfer / genetics; RNA, Transfer / metabolism; Saccharomyces cerevisiae / genetics; Superoxide Dismutase / chemistry; Superoxide Dismutase / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A genetically encoded photocaged tyrosine

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 45(17), 2728–2731.

By: A. Deiters n, D. Groff*, Y. Ryu*, J. Xie * & P. Schultz *

co-author countries: United States of America 🇺🇸
author keywords: amino acids; mutagenesis; photocaged tyrosine; proteins
MeSH headings : Molecular Structure; Photochemistry; Tyrosine / chemistry; Tyrosine / genetics; beta-Galactosidase / metabolism
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A new photocaging group for aromatic N-heterocycles

SYNTHESIS-STUTTGART, (13), 2147–2150.

By: H. Lusic* & A. Deiters*

author keywords: bioorganic chemistry; heterocycles; photocaging; protecting groups
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Conditional transgene and gene targeting methodologies in zebrafish

Zebrafish, 3, 415–429.

By: A. Deiters & J. Yoder 

Source: NC State University Libraries
Added: August 6, 2018

2006 review

General strategy for the syntheses of corynanthe, tacaman, and oxindole alkaloids

[Review of ]. JOURNAL OF ORGANIC CHEMISTRY, 71(17), 6547–6561.

By: A. Deiters*, M. Pettersson* & S. Martin *

co-author countries: United States of America 🇺🇸
MeSH headings : Alkaloids / chemical synthesis; Alkaloids / chemistry; Indole Alkaloids / chemical synthesis; Indole Alkaloids / chemistry; Indoles / chemical synthesis; Indoles / chemistry; Lactams / chemistry; Models, Molecular; Molecular Structure; Oxidation-Reduction; Oxindoles; Pausinystalia; Piperidines / chemistry
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Photochemical hammerhead ribozyme activation

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(10), 2658–2661.

By: D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: caged compounds; genomics; photochemistry; ribozymes; RNA
MeSH headings : Base Sequence; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Nucleic Acid Conformation; Photochemistry; RNA, Catalytic / chemistry; RNA, Catalytic / metabolism; Ultraviolet Rays
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Pyridines via solid-supported [2+2+2] cyclotrimerization

Chemical Communications (Cambridge, England), (12), 1313–1315.

By: R. Senaiar n, D. Young n & A. Deiters n

co-author countries: United States of America 🇺🇸
Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Solid-supported [2+2+2] cyclotrimerizations

CHEMISTRY-A EUROPEAN JOURNAL, 12(21), 5563–5568.

By: D. Young n, R. Senaiar n & A. Deiters n

co-author countries: United States of America 🇺🇸
author keywords: combinatorial chemistry; cyclotrimerization; homogeneous catalysis; solid-phase synthesis
Source: Web Of Science
Added: August 6, 2018

2004 review

Synthesis of oxygen- and nitrogen-containing heterocycles by ring-closing metathesis

[Review of ]. CHEMICAL REVIEWS, 104(5), 2199–2238.

By: A. Deiters n & S. Martin  n

co-author countries: United States of America 🇺🇸
MeSH headings : Heterocyclic Compounds / chemical synthesis; Heterocyclic Compounds / chemistry; Molecular Structure; Nitrogen / chemistry; Oxygen / chemistry
Source: Web Of Science
Added: August 6, 2018