Alexander Deiters

Dissection of MKK6 and p38 Signaling Using Light‐Activated Protein Kinases

Rahman, S. M. T., Zhou, W., Deiters, A., & Haugh, J. M. (2023, October 19). ChemBioChem, Vol. 11.

Isoform-specific optical activation of kinase function reveals p38-ERK signaling crosstalk

RSC CHEMICAL BIOLOGY, Vol. 8.

Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells

Emanuelson, C., Ankenbruck, N., Kumbhare, R., Thomas, M., Connelly, C., Baktash, Y., … Deiters, A. (2022, November 30). Journal of Medicinal Chemistry.

Optical control of MAP kinase kinase 6 (MKK6) reveals that it has divergent roles in pro-apoptotic and anti-proliferative signaling

Rahman, S. M. T., Zhou, W., Deiters, A., & Haugh, J. M. (2020, May 5). Journal of Biological Chemistry, Vol. 295, pp. 8494–8504.

A concise synthesis of the Lycopodium alkaloid cermizine D

Enamorado, M. F., Connelly, C. M., Deiters, A., & Comins, D. L. (2015, April 11). Tetrahedron Letters.

Conditional Control of Alternative Splicing through Light-Triggered Splice-Switching Oligonucleotides

Hemphill, J., Liu, Q., Uprety, R., Samanta, S., Tsang, M., Juliano, R. L., & Deiters, A. (2015, March 3). Journal of the American Chemical Society.

Light-cleavable rapamycin dimer as an optical trigger for protein dimerization

Brown, K. A., Zou, Y., Shirvanyants, D., Zhang, J., Samanta, S., Mantravadi, P. K., … Deiters, A. (2015, January 1). Chemical Communications.

Optically triggered immune response through photocaged oligonucleotides

Govan, J. M., Young, D. D., Lively, M. O., & Deiters, A. (2015, February 3). Tetrahedron Letters.

Control of Protein Function through Optochemical Translocation

Engelke, H., Chou, C., Uprety, R., Jess, P., & Deiters, A. (2014, February 4). ACS Synthetic Biology.

Correction: Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

Lee, Y.-J., Kurra, Y., Yang, Y., Torres-Kolbus, J., Deiters, A., & Liu, W. R. (2014, January 1). Chemical Communications.

Genetic Encoding of Caged Cysteine and Caged Homocysteine in Bacterial and Mammalian Cells

Uprety, R., Luo, J., Liu, J., Naro, Y., Samanta, S., & Deiters, A. (2014, June 27). ChemBioChem.

Genetically encoded unstrained olefins for live cell labeling with tetrazine dyes

Lee, Y.-J., Kurra, Y., Yang, Y., Torres-Kolbus, J., Deiters, A., & Liu, W. R. (2014, January 1). Chemical Communications.

Intracellular Light-Activation of Riboswitch Activity

ChemBioChem, 15(9), 1346–1351.

MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons

Volvert, M.-L., Prévot, P.-P., Close, P., Laguesse, S., Pirotte, S., Hemphill, J., … Nguyen, L. (2014, May 1). Cell Reports.

Site-Specific Promoter Caging Enables Optochemical Gene Activation in Cells and Animals

Hemphill, J., Govan, J., Uprety, R., Tsang, M., & Deiters, A. (2014, April 27). Journal of the American Chemical Society.

Synthesis of Non-linear Protein Dimers through a Genetically Encoded Thiol-ene Reaction

Torres-Kolbus, J., Chou, C., Liu, J., & Deiters, A. (2014, September 2). PLoS ONE.

Thiourea-Based Fluorescent Chemosensors for Aqueous Metal Ion Detection and Cellular Imaging

Vonlanthen, M., Connelly, C. M., Deiters, A., Linden, A., & Finney, N. S. (2014, June 12). The Journal of Organic Chemistry.

Two Rapid Catalyst-Free Click Reactions for In Vivo Protein Labeling of Genetically Encoded Strained Alkene/Alkyne Functionalities

Kurra, Y., Odoi, K. A., Lee, Y.-J., Yang, Y., Lu, T., Wheeler, S. E., … Liu, W. R. (2014, August 26). Bioconjugate Chemistry.

Cellular Delivery and Photochemical Activation of Antisense Agents through a Nucleobase Caging Strategy

Govan, J. M., Uprety, R., Thomas, M., Lusic, H., Lively, M. O., & Deiters, A. (2013, August 5). ACS Chemical Biology.

DNA Computation in Mammalian Cells: MicroRNA Logic Operations

Hemphill, J., & Deiters, A. (2013, June 24). Journal of the American Chemical Society.

Genetically Encoded Light-Activated Transcription for Spatiotemporal Control of Gene Expression and Gene Silencing in Mammalian Cells

Hemphill, J., Chou, C., Chin, J. W., & Deiters, A. (2013, August 9). Journal of the American Chemical Society.

MicroRNA miR-122 as a Therapeutic Target for Oligonucleotides and Small Molecules

Thomas, M., & Deiters, A. (2013, August 1). Current Medicinal Chemistry.

Optochemical Control of Deoxyoligonucleotide Function via a Nucleobase-Caging Approach

Liu, Q., & Deiters, A. (2013, August 28). Accounts of Chemical Research.

Optochemical control of RNA interference in mammalian cells

Govan, J. M., Young, D. D., Lusic, H., Liu, Q., Lively, M. O., & Deiters, A. (2013, September 10). Nucleic Acids Research.

DNA Computation: A Photochemically Controlled AND Gate

Prokup, A., Hemphill, J., & Deiters, A. (2012, January 9). Journal of the American Chemical Society.

Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction

Lang, K., Davis, L., Torres-Kolbus, J., Chou, C., Deiters, A., & Chin, J. W. (2012, February 3). Nature Chemistry.

High-Throughput Luciferase Reporter Assay for Small-Molecule Inhibitors of MicroRNA Function

Connelly, C. M., Thomas, M., & Deiters, A. (2012, March 13). SLAS DISCOVERY.

Hydrogen Peroxide Induced Activation of Gene Expression in Mammalian Cells using Boronate Estrone Derivatives

Govan, J. M., McIver, A. L., Riggsbee, C., & Deiters, A. (2012, July 31). Angewandte Chemie International Edition.

Light-controlled synthetic gene circuits

Gardner, L., & Deiters, A. (2012, May 25). Current Opinion in Chemical Biology.

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

Arbely, E., Torres-Kolbus, J., Deiters, A., & Chin, J. W. (2012, July 3). Journal of the American Chemical Society.

Regulation of Transcription through Light-Activation and Light-Deactivation of Triplex-Forming Oligonucleotides in Mammalian Cells

Govan, J. M., Uprety, R., Hemphill, J., Lively, M. O., & Deiters, A. (2012, April 27). ACS Chemical Biology.

Spatiotemporal control of microRNA function using light-activated antagomirs

Connelly, C. M., Uprety, R., Hemphill, J., & Deiters, A. (2012, September 3). Molecular BioSystems.

A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos

Development, 139(2), 437–442.

Efficacy of C–N Coupling Reactions with a New Multinuclear Copper Complex Catalyst and Its Dissociation into Mononuclear Species

Zou, Y., Lin, H., Maggard, P. A., & Deiters, A. (2011, May 27). European Journal of Organic Chemistry, pp. 4154–4159.

Heterotaxin: A TGF-β Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

Dush, M. K., McIver, A. L., Parr, M. A., Young, D. D., Fisher, J., Newman, D. R., … Nascone-Yoder, N. (2011, February 1). Chemistry & Biology, Vol. 18, pp. 252–263.

Light-Activated Kinases Enable Temporal Dissection of Signaling Networks in Living Cells

Gautier, A., Deiters, A., & Chin, J. W. (2011, January 27). Journal of the American Chemical Society.

Light‐Activated Gene Editing with a Photocaged Zinc‐Finger Nuclease

Chou, C., & Deiters, A. (2011, June 10). Angewandte Chemie International Edition.

Photochemical Control of DNA Decoy Function Enables Precise Regulation of Nuclear Factor κB Activity

Govan, J. M., Lively, M. O., & Deiters, A. (2011, July 15). Journal of the American Chemical Society.

Photochemical control of bacterial signal processing using a light-activated erythromycin

Gardner, L., Zou, Y., Mara, A., Cropp, T. A., & Deiters, A. (2011, July 22). Molecular BioSystems.

Stabilization and Photochemical Regulation of Antisense Agents through PEGylation

Govan, J. M., McIver, A. L., & Deiters, A. (2011, September 30). Bioconjugate Chemistry.

Synthesis of the Pyridine Core of Cyclothiazomycin

Zou, Y., Liu, Q., & Deiters, A. (2011, July 15). Organic Letters.

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

Young, D. D., Lively, M. O., & Deiters, A. (2010, April 14). Journal of the American Chemical Society.

Expanding the Genetic Code of Yeast for Incorporation of Diverse Unnatural Amino Acids via a Pyrrolysyl-tRNA Synthetase/tRNA Pair

Hancock, S. M., Uprety, R., Deiters, A., & Chin, J. W. (2010, October 6). Journal of the American Chemical Society.

Generating Permissive Site-Specific Unnatural Aminoacyl-tRNA Synthetases

Miyake-Stoner, S. J., Refakis, C. A., Hammill, J. T., Lusic, H., Hazen, J. L., Deiters, A., & Mehl, R. A. (2010, January 18). Biochemistry.

Genetically encoded photocontrol of protein localization in mammalian cells

Journal of the American Chemical Society, 132(12), 4086-.

Genetically encoding an aliphatic diazirine for protein photocrosslinking

Chou, C., Uprety, R., Davis, L., Chin, J. W., & Deiters, A. (2010, December 1). Chemical Science.

Improved Synthesis of the Two-Photon Caging Group 3-Nitro-2-Ethyldibenzofuran and Its Application to a Caged Thymidine Phosphoramidite

Lusic, H., Uprety, R., & Deiters, A. (2010, January 29). Organic Letters.

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

Karginov, A. V., Zou, Y., Shirvanyants, D., Kota, P., Dokholyan, N. V., Young, D. D., … Deiters, A. (2010, December 16). Journal of the American Chemical Society.

Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos

Journal of the American Chemical Society, 132(44), 15644–15650.

Photocaged T7 RNA Polymerase for the Light Activation of Transcription and Gene Function in Pro‐ and Eukaryotic Cells

Chou, C., Young, D. D., & Deiters, A. (2010, March 20). ChemBioChem.

Photocleavable Polyethylene Glycol for the Light-Regulation of Protein Function

Georgianna, W. E., Lusic, H., McIver, A. L., & Deiters, A. (2010, July 22). Bioconjugate Chemistry.

Recent advances in the photochemical control of protein function

Riggsbee, C. W., & Deiters, A. (2010, July 30). Trends in Biotechnology.

Reversible Light Switching of Cell Signalling by Genetically Encoded Protein Dimerization

Georgianna, W. E., & Deiters, A. (2010, January 8). ChemBioChem.

Site-Specific Incorporation of Fluorotyrosines into Proteins in Escherichia coli by Photochemical Disguise

Wilkins, B. J., Marionni, S., Young, D. D., Liu, J., Wang, Y., Salvo, M. L. D., … Cropp, T. A. (2010, February 5). Biochemistry.

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

Young, D. D., Connelly, C. M., Grohmann, C., & Deiters, A. (2010, May 19). Journal of the American Chemical Society.

The Human Mitochondrial tRNAMet: Structure/Function Relationship of a Unique Modification in the Decoding of Unconventional Codons

Bilbille, Y., Gustilo, E. M., Harris, K. A., Jones, C. N., Lusic, H., Kaiser, R. J., … Agris, P. F. (2010, December 18). Journal of Molecular Biology.

Total Synthesis of Cryptoacetalide

Zou, Y., & Deiters, A. (2010, June 25). The Journal of Organic Chemistry.

Tricyclic Alkaloid Core Structures Assembled by a Cyclotrimerization−Coupled Intramolecular Nucleophilic Substitution Reaction

McIver, A. L., & Deiters, A. (2010, February 23). Organic Letters.

A Light‐Activated DNA Polymerase

Chou, C., Young, D. D., & Deiters, A. (2009, June 30). Angewandte Chemie International Edition.

Development of a Robust and High Throughput Method for Profiling N-Linked Glycans Derived from Plasma Glycoproteins by NanoLC−FTICR Mass Spectrometry

Bereman, M. S., Young, D. D., Deiters, A., & Muddiman, D. C. (2009, May 12). Journal of Proteome Research, Vol. 8, pp. 3764–3770.

Genetic Encoding and Labeling of Aliphatic Azides and Alkynes in Recombinant Proteins via a Pyrrolysyl-tRNA Synthetase/tRNA_CUA Pair and Click Chemistry

Nguyen, D. P., Lusic, H., Neumann, H., Kapadnis, P. B., Deiters, A., & Chin, J. W. (2009, June 10). Journal of the American Chemical Society.

Light activation as a method of regulating and studying gene expression

Deiters, A. (2009, October 25). Current Opinion in Chemical Biology.

Light-Activated Cre Recombinase as a Tool for the Spatial and Temporal Control of Gene Function in Mammalian Cells

Edwards, W. F., Young, D. D., & Deiters, A. (2009, May 4). ACS Chemical Biology.

Open-Vessel Microwave-Mediated [2+2+2]-Cyclotrimerization Reactions

Deiters, A., Young, D., & Teske, J. (2009, October 7). Synthesis.

Photochemical Regulation of Restriction Endonuclease Activity

Young, D. D., Govan, J. M., Lively, M. O., & Deiters, A. (2009, June 16). ChemBioChem.

Principles and Applications of the Photochemical Control of Cellular Processes

Deiters, A. (2009, November 12). ChemBioChem.

Restriction enzyme-free mutagenesis via the light regulation of DNA polymerization

Nucleic Acids Research, 37(8).

Small Molecule Modifiers of the microRNA and RNA Interference Pathway

Deiters, A. (2009, November 24). The AAPS Journal.

The effect of microwave irradiation on DNA hybridization

Edwards, W. F., Young, D. D., & Deiters, A. (2009, January 1). Organic & Biomolecular Chemistry.

A Cyclotrimerization Route to Cannabinoids

Teske, J. A., & Deiters, A. (2008, May 2). Organic Letters.

A general approach to triphenylenes and azatriphenylenes: total synthesis of dehydrotylophorine and tylophorine

McIver, A., Young, D. D., & Deiters, A. (2008, January 1). Chemical Communications.

Gene Silencing in Mammalian Cells with Light-Activated Antisense Agents

ChemBioChem, 9(18), 2937–2940.

Light-activated deoxyguanosine: photochemical regulation of peroxidase activity

Lusic, H., Lively, M. O., & Deiters, A. (2008, April 8). Molecular BioSystems.

Light-activation of gene function in mammalian cells via ribozymes

Chem. Commun., (5), 568–570.

Light‐Regulated RNA–Small Molecule Interactions

Young, D. D., & Deiters, A. (2008, April 11). ChemBioChem.

Microwave Activation of Enzymatic Catalysis

Young, D. D., Nichols, J., Kelly, R. M., & Deiters, A. (2008, July 10). Journal of the American Chemical Society, Vol. 130, p. 10048-.

Microwave-assisted synthesis of unnatural amino acids

Young, D. D., Torres-Kolbus, J., & Deiters, A. (2008, September 11). Bioorganic & Medicinal Chemistry Letters.

Small‐Molecule Inhibitors of MicroRNA miR‐21 Function

Gumireddy, K., Young, D. D., Xiong, X., Hogenesch, J. B., Huang, Q., & Deiters, A. (2008, August 19). Angewandte Chemie International Edition.

Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNAMet

Lusic, H., Gustilo, E. M., Vendeix, F. A. P., Kaiser, R., Delaney, M. O., Graham, W. D., … Deiters, A. (2008, October 16). Nucleic Acids Research.

Synthesis of Anthracene and Azaanthracene Fluorophores via [2+2+2] Cyclotrimerization Reactions

Zou, Y., Young, D. D., Cruz-Montanez, A., & Deiters, A. (2008, September 25). Organic Letters.

A General Approach to Chemo‐ and Regioselective Cyclotrimerization Reactions

Young, D. D., & Deiters, A. (2007, May 25). Angewandte Chemie International Edition.

Light-triggered polymerase chain reaction

Young, D. D., Edwards, W. F., Lusic, H., Lively, M. O., & Deiters, A. (2007, November 14). Chemical Communications.

Microwave-Assisted Solid-Supported Alkyne Cyclotrimerization Reactions for Combinatorial Chemistry

Young, D. D., Sripada, L., & Deiters, A. (2007, July 21). Journal of Combinatorial Chemistry.

Microwave-Mediated Nickel-Catalyzed Cyclotrimerization Reactions:  Total Synthesis of Illudinine

Teske, J. A., & Deiters, A. (2007, December 5). The Journal of Organic Chemistry.

Phenanthridine synthesis via [2+2+2] cyclotrimerization reactions

Sripada, L., Teske, J. A., & Deiters, A. (2007, December 3). Organic & Biomolecular Chemistry.

Photochemical Activation of Protein Expression in Bacterial Cells

Young, D. D., & Deiters, A. (2007, April 25). Angewandte Chemie International Edition.

Photochemical DNA Activation

Lusic, H., Young, D. D., Lively, M. O., & Deiters, A. (2007, April 21). Organic Letters.

Synthesis of Indanones via Solid-Supported [2+2+2] Cyclotrimerization

Senaiar, R. S., Teske, J. A., Young, D. D., & Deiters, A. (2007, September 1). The Journal of Organic Chemistry.

A Genetically Encoded Photocaged Tyrosine

Deiters, A., Groff, D., Ryu, Y., Xie, J., & Schultz, P. G. (2006, March 20). Angewandte Chemie International Edition.

A New Photocaging Group for Aromatic N-Heterocycles

Deiters, A., & Lusic, H. (2006, July 1). Synthesis.

A genetically encoded fluorescent amino acid

Summerer, D., Chen, S., Wu, N., Deiters, A., Chin, J. W., & Schultz, P. G. (2006, June 19). Proceedings of the National Academy of Sciences.