Ahmad Ud Din

Also known as: Ahmad

Gut microbiome, IBD, Probiotics, miRNA, CVD, Atherosclerosis, Mice Model, DSS/TNBS, T2D

Postdoctoral researcher with 7+ years of experience in microbiome research, probiotics, and host–microbe interactions. My research focuses on how plant-based bioactives and probiotics affect microbial metabolites, such as TMAO, gut barrier function, and chronic inflammation. I integrate in vivo models, anaerobic fermentation, LC-MS, and molecular tools (qPCR, ELISA, 16S rRNA) to explore nutrition-based strategies for disease prevention and health promotion. more

Works (41)

Updated: March 9th, 2026 08:11

2025 article

Behavioral alterations in antibiotic-treated mice associated with gut microbiota dysbiosis: insights from 16S rRNA and metabolomics

Bibi, A., Zhang, F., Shen, J., Din, A. U., & Xu, Y. (2025, February 28). Frontiers in Neuroscience, Vol. 19.

By: A. Bibi*, F. Zhang*, J. Shen*, A. Din n & Y. Xu*

author keywords: gut microbiota; antibiotic; gut dysbiosis; brain; metabolome; anxiety-like behavior
topics (OpenAlex): Gut microbiota and health; Diet and metabolism studies; Dietary Effects on Health; Tryptophan and brain disorders; Clostridium difficile and Clostridium perfringens research
Sources: Web Of Science, NC State University Libraries
Added: March 24, 2025

2025 article

Computational Comparative Analysis of Esophageal Microbial Communities and Metabolic Profiles in Erosive and Nonerosive Phenotypes of Gastroesophageal Reflux Disease

Shah, S. R. H., Ullah, A., Aziz, S., Rasheed, F., Syed, A., Din, A. U., … Alhomrani, M. (2025, March 19). Journal of Computational Biophysics and Chemistry, Vol. 3.

topics (OpenAlex): Esophageal Cancer Research and Treatment; Gastroesophageal reflux and treatments
Sources: NC State University Libraries, NC State University Libraries
Added: March 4, 2026

2025 article

Establishing reliable blood biomarkers for trimethylamine N-oxide status in rodents: Effects of oral choline challenge, dietary choline and fasting conditions

Din, A. U., Sweet, M. G., McAmis, A. M., Ratliff, J. G., Babu, P. V. A., & Neilson, A. P. (2025, March 21). The Journal of Nutritional Biochemistry, Vol. 7.

By: A. Din n, M. Sweet n, A. McAmis n, J. Ratliff n, P. Babu* & A. Neilson n

author keywords: Atherosclerosis; Cardiovascular disease; Choline; Dietary intervention; Fasting; Oral gavage; TMAO.
topics (OpenAlex): Diet and metabolism studies; Diet, Metabolism, and Disease; Biochemical effects in animals
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 10, 2025

2025 article

Exploring age-related changes in gut bacterial community composition of yak: insights from different age groups

Shah, T., Guo, X., Ahmad, G., Ishaq, M., Din, A. U., Sardar, S., & Ding, L. (2025, May 16). BMC Microbiology, Vol. 25.

By: T. Shah*, X. Guo*, G. Ahmad*, M. Ishaq*, A. Din n, S. Sardar*, L. Ding

author keywords: Gut microbiota; Bacterial diversity; Maturity; Domesticated yaks
MeSH headings : Animals; Cattle / microbiology; Gastrointestinal Microbiome; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; RNA, Ribosomal, 16S / genetics; Feces / microbiology; Age Factors; DNA, Bacterial / genetics; Phylogeny; Sequence Analysis, DNA; Biodiversity; Tibet
topics (OpenAlex): Gut microbiota and health; Cassava research and cyanide; Probiotics and Fermented Foods
Sources: Web Of Science, NC State University Libraries
Added: May 27, 2025

2024 article

Deciphering Microbiome, Transcriptome, and Metabolic Interactions in the Presence of Probiotic Lactobacillus acidophilus against Salmonella Typhimurium in a Murine Model

Junaid, M., Lu, H., Din, A. U., Yu, B., Liu, Y., Li, Y., … Qi, Z. (2024, April 11). Antibiotics, Vol. 13.

author keywords: microbiome; transcriptome; metabolome; immunity; gut barrier integrity; mice; Salmonella Typhimurium; L. acidophilus
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Cancer Research and Treatments
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 article

Impact of Probiotic Lactiplantibacillus plantarum ATCC 14917 on atherosclerotic plaque and its mechanism

Hassan, A., Luqman, A., Zhang, K., Ullah, M., Din, A. U., Xiaoling, L., & Wang, G. (2024, May 10). World Journal of Microbiology and Biotechnology, Vol. 40.

By: A. Hassan*, A. Luqman*, K. Zhang*, M. Ullah*, A. Din n, L. Xiaoling*, G. Wang

author keywords: Atherosclerosis; Lactiplantibacillus plantarum ATCC 14917; Apoe(-/-) mice; Inflammation
MeSH headings : Animals; Probiotics / administration & dosage; Probiotics / pharmacology; Plaque, Atherosclerotic; Mice; Atherosclerosis / microbiology; Apolipoproteins E / genetics; Male; Disease Models, Animal; Mice, Knockout; Diet, High-Fat; Lactobacillus plantarum; Cytokines / metabolism; Mice, Inbred C57BL; Inflammation
topics (OpenAlex): Microbial Metabolism and Applications; Gut microbiota and health; Microbial Metabolites in Food Biotechnology
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2024

2024 article

Integrons in the Age of Antibiotic Resistance: Evolution, Mechanisms, and Environmental Implications: A Review

Ali, N., Ali, I., Din, A. U., Akhtar, K., He, B., & Wen, R. (2024, December 13). Microorganisms, Vol. 12.

author keywords: integrons; gene cassettes; environment; antimicrobial resistance
topics (OpenAlex): Antibiotic Resistance in Bacteria; Pharmaceutical and Antibiotic Environmental Impacts; Bacteriophages and microbial interactions
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2024 article

Lacticaseibacillusparacasei BNCC345679 revolutionizes DSS-induced colitis and modulates gut microbiota

Ahmad, W., Din, A. U., Khan, T. M., Rehman, M. U., Hassan, A., Aziz, T., … Wu, J. (2024, March 27). Frontiers in Microbiology, Vol. 15.

author keywords: DSS-induced colitis; dysbiosis; microRNA; gut microbiota; gut inflammation; probiotics; Lacticaseibacillus paracasei BNCC345679
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Inflammatory Bowel Disease
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 article

Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Luqman, A., He, M., Hassan, A., Ullah, M., Zhang, L., Khan, M. R., … Wang, G. (2024, February 9). Frontiers in Psychiatry, Vol. 15.

By: A. Luqman*, M. He*, A. Hassan*, M. Ullah*, L. Zhang, M. Khan*, A. Din n, K. Ullah, W. Wang*, G. Wang*

author keywords: depressive disorder; gut microbiota; gut-brain axis (GBA); dysbiosis; metabolites; probiotics; prebiotics; FMT
topics (OpenAlex): Gut microbiota and health; Tryptophan and brain disorders; Diet and metabolism studies
TL;DR: The results support the hypothesis that gut microbiota influences depression and provide a promising area of research for an improved knowledge of the etiology of the disease and future therapies. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024

2024 article

Novel Synergistic Probiotic Intervention: Transcriptomic and Metabolomic Analysis Reveals Ameliorative Effects on Immunity, Gut Barrier, and Metabolism of Mice during Salmonella typhimurium Infection

Junaid, M., Lu, H., Li, Y., Liu, Y., Din, A. U., Qi, Z., … Yan, J. (2024, March 29). Genes, Vol. 15.

By: M. Junaid*, H. Lu*, Y. Li*, Y. Liu*, A. Din n, Z. Qi*, Y. Xiong*, J. Yan*

author keywords: synergistic probiotics; immunity; metabolism; gut barrier; Lactobacillus acidophilus; Lactobacillus plantarum; Salmonella typhimurium
MeSH headings : Animals; Probiotics / pharmacology; Probiotics / administration & dosage; Mice; Salmonella typhimurium; Transcriptome; Lactobacillus plantarum; Mice, Inbred BALB C; Lactobacillus acidophilus; Metabolome; Metabolomics / methods; Salmonella Infections / immunology; Salmonella Infections / genetics; Salmonella Infections / microbiology; Salmonella Infections / metabolism; Salmonella Infections, Animal / immunology; Salmonella Infections, Animal / microbiology; Salmonella Infections, Animal / genetics; Salmonella Infections, Animal / metabolism; Female; Gastrointestinal Microbiome / drug effects
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Metabolomics and Mass Spectrometry Studies
TL;DR: It is suggested that the administration of a probiotic mixture improves immunity, maintains gut homeostasis and barrier integrity, and enhances metabolism in Salmonella infection. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 1, 2024

2024 article

Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder

Luqman, A., Hassan, A., Ullah, M., Naseem, S., Ullah, M., Zhang, L., … Wang, G. (2024, January 26). Frontiers in Immunology, Vol. 15.

By: A. Luqman*, A. Hassan*, M. Ullah*, S. Naseem*, M. Ullah*, L. Zhang, A. Din n, K. Ullah*, W. Ahmad*, G. Wang*

author keywords: CVD; HF; HTN; TMAO; SCFAs; FMT
MeSH headings : Humans; Cardiovascular Diseases / therapy; Cardiovascular Diseases / etiology; Gastrointestinal Microbiome / physiology; Microbiota; Hypertension / complications; Atherosclerosis / complications; Methylamines
topics (OpenAlex): Gut microbiota and health; Diet and metabolism studies; Nutritional Studies and Diet
TL;DR: Current evidence highlighting the intricate links between gut microbiota, metabolites, and the development of CVD is compiled, focusing on how intestinal dysbiosis promotes CVD risk factors such as heart failure, hypertension, and atherosclerosis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024

2023 article

A narrative review: CXC chemokines influence immune surveillance in obesity and obesity-related diseases: Type 2 diabetes and nonalcoholic fatty liver disease

Ullah, A., Din, A. U., Ding, W., Shi, Z., Pervaz, S., & Shen, B. (2023, March 31). Reviews in Endocrine and Metabolic Disorders.

MeSH headings : Humans; Non-alcoholic Fatty Liver Disease / metabolism; Diabetes Mellitus, Type 2 / metabolism; Chemokines, CXC / metabolism; Obesity / metabolism; Insulin Resistance; Inflammation / metabolism; Liver / metabolism
topics (OpenAlex): Liver Disease Diagnosis and Treatment; Adipokines, Inflammation, and Metabolic Diseases; Diabetes and associated disorders
TL;DR: Because CXC chemokine profiling is strongly linked to leukocyte recruitment, macrophage recruitment, and immunomodulatory potential, it is hypothesize that it could be used to predict the therapeutic potential for obesity and obesity-related diseases (T2D and NAFLD). (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2023 article

Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery

Xue, L., Ding, Y., Qin, Q., Liu, L., Ding, X., Zhou, Y., … Miao, L. (2023, January 19). Frontiers in Cellular and Infection Microbiology, Vol. 12.

By: L. Xue*, Y. Ding*, Q. Qin*, L. Liu*, X. Ding*, Y. Zhou*, K. Liu*, R. Singla* ...

MeSH headings : Humans; Aged; Gastrointestinal Microbiome; Anti-Bacterial Agents / therapeutic use; Anti-Bacterial Agents / pharmacology; RNA, Ribosomal, 16S / genetics; Vitamin K 2 / pharmacology; Cardiac Surgical Procedures; Feces / microbiology
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Microscopic Colitis
TL;DR: The composition of the gut microbiota had a significant change post-intravenous antibiotics treatment in cardiac surgery patients, and the richness and diversity of gut microbiota are increased in elderly patients. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 6, 2023

2023 article

Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota

Xu, J., Tang, C., Din, A. U., Lu, Y., Ma, X., Zhang, T., … Wu, J. (2023, March 17). Biomedicine & Pharmacotherapy, Vol. 161, p. 114562.

By: J. Xu*, C. Tang*, A. Din*, Y. Lu*, X. Ma*, T. Zhang*, J. Wu*, D. Zuoqin*, P. Luo*, J. Wu*

MeSH headings : Animals; Mice; Dextran Sulfate / pharmacology; Polygonatum; Gastrointestinal Microbiome; Mice, Inbred C57BL; Colitis / chemically induced; Colitis / drug therapy; Colitis / microbiology; Colitis, Ulcerative / drug therapy; Inflammatory Bowel Diseases / chemically induced; Oligosaccharides / pharmacology; Disease Models, Animal; Colon
topics (OpenAlex): Inflammatory Bowel Disease; Helicobacter pylori-related gastroenterology studies; Polysaccharides and Plant Cell Walls
TL;DR: Results showed that doses of PFOS alleviated the DSS-induced histopathological damage and improved intestinal barrier function, suggesting that PFOS might be used as an efficacious supplement for reducing inflammatory bowel disease. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 6, 2023

2023 article

Translational informatics for human microbiota: data resources, models and applications

Shen, K., Din, A. U., Sinha, B., Zhou, Y., Qian, F., & Shen, B. (2023, May 1). Briefings in Bioinformatics, Vol. 24.

By: K. Shen*, A. Din*, B. Sinha*, Y. Zhou*, F. Qian* & B. Shen*

MeSH headings : Humans; Genomics / methods; Medical Informatics; Computational Biology / methods; Translational Research, Biomedical; Biomedical Research
topics (OpenAlex): Gut microbiota and health; Bioinformatics and Genomic Networks; Biomedical Text Mining and Ontologies
TL;DR: A landscape of the data resources, a comparison of the computational models and a summary of the translational informatics applied to microbiota data, including biomarker discovery, personalized treatment and smart healthcare for complex diseases are provided. (via Semantic Scholar)
Source: ORCID
Added: August 6, 2023

2022 article

Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target

Shinge, S. A. U., Zhang, D., Din, A. U., Yu, F. X., & Nie, Y. M. (2022, January 1). International Journal of Biological Sciences.

By: S. Shinge*, D. Zhang*, A. Din*, F. Yu* & Y. Nie*

Contributors: S. Shinge*, D. Zhang*, A. Ud Din*, F. Yu* & Y. Nie*

MeSH headings : Apoptosis; Atherosclerosis / drug therapy; Humans; Inflammation / drug therapy; Ion Channels / genetics; Ion Channels / metabolism; Mechanotransduction, Cellular; Signal Transduction / genetics
topics (OpenAlex): Erythrocyte Function and Pathophysiology; Blood properties and coagulation; Ion Channels and Receptors
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2022 article

Evaluation of Cardiac Biomarkers and Expression Analysis of IL-1, IL-6, IL-10, IL-17, and IL-25 among COVID-19 Patients from Pakistan

Ullah, R., Khan, J., Basharat, N., Huo, D., Din, A. U., & Wang, G. (2022, September 29). Viruses.

By: R. Ullah*, J. Khan*, N. Basharat*, D. Huo*, A. Din* & G. Wang*

MeSH headings : Humans; COVID-19; SARS-CoV-2; Interleukin-6; Interleukin-10; Interleukin-17 / genetics; Pakistan; Biomarkers; Cytokines; Troponin; Interleukin-1
topics (OpenAlex): COVID-19 Clinical Research Studies; Long-Term Effects of COVID-19; SARS-CoV-2 and COVID-19 Research
TL;DR: It is concluded that the evaluation of cardiac biomarkers with cytokine storm plays a significant role in COVID-19-associated anatomical organ damage, myocardial injury, and mortality and Physicians should pay special attention to cardiac biomarker in patients with old age, inflammation, and comorbidities among CO VID-19 infections. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2022 article

Isolation, characterization, bacteriocin production and biological potential of Bifidobacteria of ruminants

Zafar, M., Alam, S., Sabir, M., Saba, N., Din, A. U., Ahmad, R., … Dayisoylu, K. S. (2022, September 30). Analytical Biochemistry, Vol. 658, p. 114926.

By: M. Zafar*, S. Alam*, M. Sabir*, N. Saba*, A. Din*, R. Ahmad*, M. Khan*, A. Muhammad*, K. Dayisoylu*

MeSH headings : Animals; Acrylamides; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / chemistry; Bacteriocins / pharmacology; Bacteriocins / chemistry; Bifidobacterium; Edetic Acid; Escherichia coli; Glucose; Hydrogen-Ion Concentration; Ruminants / microbiology; Sodium Chloride; Sodium Dodecyl Sulfate; Staphylococcus aureus; Urea
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: It is indicated that bifidobacterial bacteriocins have considerable potential to be used as biopreservative. (via Semantic Scholar)
Source: ORCID
Added: August 6, 2023

2022 article

Metagenomic Analysis of Liquor Starter Culture Revealed Beneficial Microbes’ Presence

Din, A. U., Ahmad, W., Khan, T. M., Wang, J., & Wu, J. (2022, December 21). Foods.

By: A. Din*, W. Ahmad*, T. Khan*, J. Wang & J. Wu*

topics (OpenAlex): Fermentation and Sensory Analysis; Microbial Metabolism and Applications; Fungal Biology and Applications
TL;DR: This study identified beneficial microbes in the starter culture of Zaopei Baijiu Daqu (ZBD) starter cultures, opening a path for further in-depth analysis of those microbes by isolating and evaluating them for a valuable role in in vitro and in vivo studies. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2022 article

Seroprevalence of Anti‐tTg‐IgA among Symptomized Celiac Disease Patients and Their Correlation with Rotavirus Infection

Sadiq, A., Khan, J., Ullah, I., Basharat, N., Ali, S., Din, A. U., … Khan, I. A. (2022, January 1). (H.-F. Pan, Ed.). BioMed Research International.

By: A. Sadiq, J. Khan*, I. Ullah*, N. Basharat*, S. Ali*, A. Din*, I. Ali*, A. Farid* ...

Ed(s): H. Pan*

MeSH headings : Adolescent; Autoantibodies; Celiac Disease / epidemiology; Child; Child, Preschool; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Glutens; Humans; Immunoglobulin A / analysis; Rotavirus Infections / epidemiology; Seroepidemiologic Studies; Transglutaminases
topics (OpenAlex): Celiac Disease Research and Management; Microscopic Colitis; Viral gastroenteritis research and epidemiology
TL;DR: The study findings demonstrate that Pakistan has a high prevalence of CD compared to other studies, and further studies in the fields of environmental risk factors and treatment with more advanced serological and histopathological studies are needed in the future. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2021 article

Analyzing differentially expressed Genes and Pathways of Bex2-deficient mouse lung via RNA-seq

Bahadar, N., Ullah, H., Adlat, S., Sah, R. K., Myint, M. Z. Z., Oo, Z. M., … Zheng, Y. (2021, January 1). TURKISH JOURNAL OF BIOLOGY.

By: N. Bahadar*, H. Ullah*, S. Adlat*, R. Sah*, M. Myint*, Z. Oo*, F. Bah*, F. Nagi* ...

Contributors: N. Bahadar*, H. Ullah*, S. Adlat*, R. Kumar Sah*, M. Zun Zaw Myint*, Z. Mar Oo*, F. Binta Bah*, F. Hayel Nagi* ...

topics (OpenAlex): interferon and immune responses; Immune Response and Inflammation; Neutrophil, Myeloperoxidase and Oxidative Mechanisms
TL;DR: According to gene enrichment analysis, PPAR pathway, cardiac muscle contraction, and cytokine-cytokine receptor interaction were the most enriched pathways. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2021 article

Co-infections of two carbapenemase-producing Enterobacter hormaechei clinical strains isolated from the same diabetes individual in China

Ding, M., Shi, J., Din, A. U., Liu, Y., Zhang, F., Yan, X., … Zhou, Y. (2021, February 2). Journal of Medical Microbiology.

By: M. Ding*, J. Shi*, A. Din*, Y. Liu*, F. Zhang*, X. Yan*, Q. Li*, J. Bai*, W. Chen*, Y. Zhou*

Contributors: M. Ding*, J. Shi*, A. Din*, Y. Liu*, F. Zhang*, X. Yan*, Q. Li*, J. Bai*, W. Chen*, Y. Zhou*

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Biofilms / growth & development; Carbapenem-Resistant Enterobacteriaceae / drug effects; Carbapenem-Resistant Enterobacteriaceae / genetics; Carbapenem-Resistant Enterobacteriaceae / isolation & purification; Coinfection / microbiology; Diabetes Complications / microbiology; Drug Resistance, Multiple, Bacterial / drug effects; Drug Resistance, Multiple, Bacterial / genetics; Enterobacter / drug effects; Enterobacter / genetics; Enterobacter / isolation & purification; Enterobacteriaceae Infections / microbiology; Genome, Bacterial / genetics; Humans; Male; Microbial Sensitivity Tests; Plasmids / genetics; Virulence Factors / genetics; Young Adult
topics (OpenAlex): Antibiotic Resistance in Bacteria; Pharmaceutical and Antibiotic Environmental Impacts; Bacterial biofilms and quorum sensing
TL;DR: This study reveals two multiple drug-resistant E. hormaechei isolates from diabetes patient samples, which were isolated from a patient with diabetes in Sichuan, China and were resistant to carbapenems, β-lactam, aminoglycoside, quinolone and tetracycline. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2021 article

Complete genome sequence and probiotic properties of Lactococcus petauri LZys1 isolated from healthy human gut

Li, O., Zhang, H., Wang, W., Liang, Y., Chen, W., Din, A. U., … Zhou, Y. (2021, August 16). Journal of Medical Microbiology, Vol. 70.

By: O. Li*, H. Zhang*, W. Wang*, Y. Liang*, W. Chen*, A. Din*, L. Li*, Y. Zhou*

Contributors: O. Li*, H. Zhang*, W. Wang*, Y. Liang*, W. Chen*, A. Ud Din*, L. Li*, Y. Zhou*

MeSH headings : Animals; Bacteria / growth & development; Bacteria / pathogenicity; Base Sequence; Feces / microbiology; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Lactococcus / cytology; Lactococcus / genetics; Lactococcus / isolation & purification; Lactococcus / physiology; Male; Molecular Sequence Annotation; Moths / microbiology; Phylogeny; Polysaccharides, Bacterial / biosynthesis; Polysaccharides, Bacterial / genetics; Probiotics; Whole Genome Sequencing; Young Adult
topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Microbial Metabolites in Food Biotechnology
TL;DR: All the results described in this study, together with relevant information previously reported, made L. prtauri LZys1 a very interesting potential strain to be considered as a prominent candidate for probiotic use. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2021 article

Desulfovibrio desulfuricans aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-κB pathway in Apoe mice

Zhang, K., Qin, X., Qiu, J., Sun, T., Qu, K., Din, A. U., … Wang, G. (2021, October 19). Genes & Diseases, Vol. 10.

By: K. Zhang*, X. Qin*, J. Qiu*, T. Sun*, K. Qu*, A. Din*, W. Yan*, T. Li* ...

Contributors: K. Zhang*, X. Qin*, J. Qiu*, T. Sun*, K. Qu*, A. Din*, W. Yan*, T. Li* ...

topics (OpenAlex): Advanced Glycation End Products research; Gut microbiota and health; Helicobacter pylori-related gastroenterology studies
TL;DR: TAK-242, a specific inhibitor ofTLR4, can ameliorate the development of D. desulfuricans-induced atherosclerosis by blocking the LPS-induced activation of TLR4/NF-κB signaling. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2021 article

Gut microbiome colonization and development in neonatal ruminants: Strategies, prospects, and opportunities

Arshad, M. A., Hassan, F.-ul, Rehman, M. S., Huws, S. A., Cheng, Y., & Din, A. U. (2021, May 29). Animal Nutrition.

topics (OpenAlex): Animal health and immunology; Ruminant Nutrition and Digestive Physiology; Clostridium difficile and Clostridium perfringens research
TL;DR: All the possible factors, which can influence rumen microbiome colonization and development, are explored and the advantages and disadvantages of potential strategies used to manipulate gut development and microbial colonization to improve the production and health of newborn calves at an early age when they are most susceptible to enteric disease are discussed. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2021 article

Implication of ferroptosis in aging

Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., … Yang, S. (2021, June 28). Cell Death Discovery.

topics (OpenAlex): Ferroptosis and cancer prognosis; Circular RNAs in diseases; MicroRNA in disease regulation
TL;DR: The factual evidences to support the possible role and implication of ferroptosis in aging are highlighted in order to declare the need to identify and explore the interventions to prevent excessive ferroPTosis leading to accelerated aging and associated liabilities of aging. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2021 article

Microbiota Targeted Interventions of Probiotic Lactobacillus as an Anti-Ageing Approach: A Review

Ishaq, M., Khan, A., Bacha, A. S., Shah, T., Hanif, A., Ahmad, A. A., … Guo, X. (2021, November 30). Antioxidants.

By: M. Ishaq*, A. Khan*, A. Bacha*, T. Shah*, A. Hanif*, A. Ahmad*, W. Ke*, F. Li* ...

topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Tryptophan and brain disorders
TL;DR: The role of Lactobacillus strains in restoration of gut microbiota dysbiosis and alleviating certain conditions during ageing is highlighted and its inherent effects against age-related oxidative stress as well as on the gut health and gut-brain axis are discussed. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2020 article

Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE−/− mice through modulation of proinflammatory cytokines and oxidative stress

Hassan, A., Din, A. U., Zhu, Y., Zhang, K., Li, T., Wang, Y., … Wang, G. (2020, May 29). Applied Microbiology and Biotechnology.

MeSH headings : Animals; Aorta / drug effects; Aorta / metabolism; Aorta / pathology; Apolipoproteins E / deficiency; Atherosclerosis / pathology; Atherosclerosis / prevention & control; Cytokines / metabolism; Gastrointestinal Microbiome / drug effects; Inflammation; Lactobacillus plantarum / physiology; Mice; Mice, Knockout; NF-KappaB Inhibitor alpha / metabolism; Oxidative Stress / drug effects; Probiotics / administration & dosage; Probiotics / pharmacology; Transcription Factor RelA / metabolism
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Microbial Metabolism and Applications
TL;DR: Results showed that L. plantarum ATCC 14917 supplementation decreases the progression of atherosclerotic lesion formation by alleviating the inflammatory process and lowering oxidative stress. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2020 article

Application of a Faecalibacterium 16S rDNA genetic marker for species identification of dog fecal waste

Zhang, K., Sun, D., Duan, C., Chen, H., Din, A. U., Kong, X., … Zhang, B. (2020, May 29). Environmental Science and Pollution Research.

MeSH headings : Animals; China; DNA, Ribosomal; Dogs; Faecalibacterium / genetics; Feces; Genetic Markers; Humans; RNA, Ribosomal, 16S; Reproducibility of Results
topics (OpenAlex): Fecal contamination and water quality; Gut microbiota and health; Clostridium difficile and Clostridium perfringens research
Source: ORCID
Added: August 5, 2023

2020 article

Bacterial association and comparison between lung and intestine in rats

Liu, T.-hao, Zhang, C.-yang, Din, A. U., Li, N., Wang, Q., Yu, J.-ze, … Yang, Z.-shan. (2020, April 1). Bioscience Reports, Vol. 40.

Contributors: T. Liu*, C. Zhang*, A. Din*, N. Li*, Q. Wang*, J. Yu*, Z. Xu*, C. Li* ...

MeSH headings : Animals; Bacteria / genetics; Bacteria / immunology; DNA, Bacterial / isolation & purification; Feces / microbiology; Gastrointestinal Microbiome / genetics; Lung / microbiology; Male; Models, Animal; Phylogeny; RNA, Ribosomal, 16S / genetics; Rats; Rats, Wistar; Sequence Analysis, DNA; Specific Pathogen-Free Organisms
topics (OpenAlex): Gut microbiota and health; Gastrointestinal motility and disorders; Diet and metabolism studies; Probiotics and Fermented Foods; Helicobacter pylori-related gastroenterology studies
TL;DR: It was found that intestine bacteria was more abundant and diverse than lung bacteria, and intestine bacteria were enriched in RNA processing, modification chromatin structure, dynamics and amino acid metabolism. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: ORCID
Added: August 5, 2023

2020 article

High incidence and characteristic of PRRSV and resistant bacterial Co-Infection in pig farms

XiangjinYan, N., Zeng, J., Li, X., Zhang, Z., Din, A. U., Zhao, K., & Zhou, Y. (2020, September 24). Microbial Pathogenesis, Vol. 149, p. 104536.

By: N. XiangjinYan*, J. Zeng*, X. Li*, Z. Zhang*, A. Din*, K. Zhao*, Y. Zhou*

Contributors: X. Yan*, J. Zeng*, X. Li*, Z. Zhang*, A. Din*, K. Zhao*, Y. Zhou*

MeSH headings : Animals; China / epidemiology; Coinfection / epidemiology; Coinfection / veterinary; Escherichia coli / genetics; Genetic Variation; Incidence; Phylogeny; Porcine Reproductive and Respiratory Syndrome / epidemiology; Porcine respiratory and reproductive syndrome virus / genetics; Swine
topics (OpenAlex): Animal Virus Infections Studies; Microbial infections and disease research; Virus-based gene therapy research
TL;DR: Co-infection is common in pig farms and the orf5 gene continues to undergo its sequences divergence, and continuous study of the characteristic of PRRSV and resistant bacterial co- Infection is necessary for healthy pig aquaculture. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2020 article

Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism

Din, A. U., Hassan, A., Zhu, Y., Zhang, K., Wang, Y., Li, T., … Wang, G. (2020, February 5). The Journal of Nutritional Biochemistry, Vol. 79.

Contributors: A. Din*, A. Hassan*, Y. Zhu*, K. Zhang*, Y. Wang*, T. Li*, Y. Wang*, G. Wang*

MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Antioxidants / pharmacology; Bifidobacterium bifidum; Colitis, Ulcerative / chemically induced; Colitis, Ulcerative / drug therapy; Colitis, Ulcerative / metabolism; Colon / metabolism; Cytokines / metabolism; Dextran Sulfate / adverse effects; Disease Models, Animal; Dysbiosis / chemically induced; Dysbiosis / drug therapy; Gastrointestinal Microbiome / drug effects; Interleukin-1beta / metabolism; Male; Mice; Mice, Inbred C57BL; MicroRNAs / metabolism; NF-kappa B / metabolism; Probiotics / administration & dosage; Probiotics / pharmacology; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Mycobacterium research and diagnosis
TL;DR: The probiotic strain B. bifidum ATCC 29521 exhibited its probiotic role through its anti-inflammatory role by modulating miRNA-associated TJP and NF-κB regulation and by partially restoring dysbiosis in the DSS colitis mouse model. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2020 article

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

Din, A. U., Mazhar, M., Waseem, M., Ahmad, W., Bibi, A., Hassan, A., … Wu, J. (2020, November 11). Biomedicine & Pharmacotherapy, Vol. 11, p. 110947.

MeSH headings : COVID-19 / microbiology; Dysbiosis; Gastrointestinal Microbiome; Humans; Probiotics; SARS-CoV-2
topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Gastrointestinal motility and disorders; Clostridium difficile and Clostridium perfringens research
TL;DR: It is concluded that dysbiosis occurs during SARS-COV-2 infection as the gut-lung axis cannot be ignored and the inclusion of studies to investigate gut microbiome and subsequent therapies such as probiotics might help decrease the inflammatory response of viral pathogenesis and respiratory symptoms by strengthening the host immune system, amelioration of gut microbiome, and improvement of gut barrier function. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2020 journal article

SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 11. http://europepmc.org/abstract/PMC/PMC7657099

By: A. Din, M. Mazhar, M. Wasim, W. Ahmad, A. Bibi, A. Hassan, N. Ali, W. Gang ...

Source: ORCID
Added: August 5, 2023

2020 article

The Role of Agriculture in the Dissemination of Class 1 Integrons, Antimicrobial Resistance, and Diversity of Their Gene Cassettes in Southern China

Ali, N., Lin, Y., Qing, Z., Xiao, D., Din, A. U., Ali, I., … Wen, R. (2020, August 28). Genes, Vol. 11, p. 1014.

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / genetics; Crops, Agricultural / drug effects; Crops, Agricultural / genetics; Crops, Agricultural / microbiology; Drug Resistance, Bacterial / genetics; Genetic Variation; Integrons / genetics; Soil / chemistry; Soil Microbiology
topics (OpenAlex): Pharmaceutical and Antibiotic Environmental Impacts; Antibiotic Resistance in Bacteria; Bacterial biofilms and quorum sensing
TL;DR: This study highlights the significant differences in the abundance of integrons among various agricultural soils and offers deep insight into the pools of gene cassettes that play a key role in the dissemination ofIntegrons and AMR. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2019 article

Amelioration of TMAO through probiotics and its potential role in atherosclerosis

Din, A. U., Hassan, A., Zhu, Y., Yin, T., Gregersen, H., & Wang, G. (2019, October 26). Applied Microbiology and Biotechnology, Vol. 103, pp. 9217–9228.

MeSH headings : Animals; Atherosclerosis / physiopathology; Atherosclerosis / prevention & control; Humans; Metabolomics; Methylamines / antagonists & inhibitors; Methylamines / metabolism; Mice; MicroRNAs; Microbiota; Probiotics / therapeutic use
topics (OpenAlex): Gut microbiota and health; Tryptophan and brain disorders; Diet and metabolism studies
TL;DR: Advances in TMAO preventing strategies through probiotics, including, modulation of gut microbiome, metabolomics profile, miRNA, or probiotic antagonistic abilities, are focused on. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 5, 2023

2019 article

Beneficial effects of Enterococcus faecalis in hypercholesterolemic mice on cholesterol transportation and gut microbiota

Zhu, Y., Li, T., Din, A. U., Hassan, A., Wang, Y., & Wang, G. (2019, February 19). Applied Microbiology and Biotechnology, Vol. 103, pp. 3181–3191.

By: Y. Zhu*, T. Li*, A. Din*, A. Hassan*, Y. Wang* & G. Wang*

Contributors: Y. Zhu*, T. Li*, A. Din*, A. Hassan*, Y. Wang* & G. Wang*

MeSH headings : ATP Binding Cassette Transporter, Subfamily G, Member 5 / genetics; ATP Binding Cassette Transporter, Subfamily G, Member 8 / genetics; Administration, Oral; Animals; Bifidobacterium / isolation & purification; Biological Transport; Cholesterol / blood; Cholesterol / metabolism; Enterococcus faecalis / metabolism; Gastrointestinal Microbiome; Hypercholesterolemia / therapy; Lactobacillus / isolation & purification; Lipid Metabolism; Lipoproteins / genetics; Liver / metabolism; Male; Mice; Mice, Inbred C57BL; Microbial Interactions
topics (OpenAlex): Gut microbiota and health; Drug Transport and Resistance Mechanisms; Cholesterol and Lipid Metabolism
TL;DR: E. faecalis ATCC19433 maybe contribute to the transportation of cholesterol potentially and modulate the composition of gut microbiota and increased the counts of Lactobacillus, Bifidobacterium, and Akkermansia in hypercholesterolemic mice. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2019 article

Effect of simulated microgravity induced PI3K-nos2b signalling on zebrafish cardiovascular plexus network formation

Xie, X., Lei, D., Zhang, Q., Wang, Y., Wen, L., Ye, Z., … Wang, G. (2019, February 28). Journal of Biomechanics, Vol. 87, pp. 83–92.

MeSH headings : Animals; Cardiovascular Physiological Phenomena; Embryo, Nonmammalian; Morphogenesis; Neovascularization, Physiologic / physiology; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Phosphatidylinositol 3-Kinase / metabolism; Signal Transduction / physiology; Weightlessness; Zebrafish / embryology
topics (OpenAlex): Spaceflight effects on biology; Congenital heart defects research; Birth, Development, and Health
TL;DR: It can be concluded that SM affects zebrafish CVP network remodeling by enhancing angiogenesis and the PI3K-nos2b signaling pathway is involved in this process. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

2019 article

Updates in understanding the hypocholesterolemia effect of probiotics on atherosclerosis

Hassan, A., Din, A. U., Zhu, Y., Zhang, K., Li, T., Wang, Y., … Wang, G. (2019, June 14). Applied Microbiology and Biotechnology, Vol. 103, pp. 5993–6006.

Contributors: A. Hassan*, A. Din*, Y. Zhu*, K. Zhang*, T. Li*, Y. Wang*, Y. Luo*, G. Wang*

MeSH headings : Animals; Atherosclerosis / physiopathology; Atherosclerosis / prevention & control; Cholesterol / metabolism; Humans; Hypercholesterolemia / complications; Hypercholesterolemia / therapy; Probiotics / administration & dosage; Probiotics / pharmacology
topics (OpenAlex): Cholesterol and Lipid Metabolism; Gut microbiota and health; Probiotics and Fermented Foods
TL;DR: The aim of this review is to explore the hypercholesterolemia effect of how it progresses into atherosclerosis and to summarize the hypocholesterolaemia effect of probiotics on atheros sclerosis and the up-to-date information on their basic mechanisms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: August 5, 2023

2017 article

An overview on the progress and development on metals/non-metal catalyzed cyanation reactions

Najam, T., Shah, S. S. A., Mehmood, K., Din, A. U., Rizwan, S., Ashfaq, M., … Waseem, A. (2017, September 28). Inorganica Chimica Acta, Vol. 469, pp. 408–423.

Contributors: T. Najam*, S. Shah*, K. Mehmood*, A. Din*, S. Rizwan*, M. Ashfaq*, S. Shaheen*, A. Waseem*

topics (OpenAlex): Sulfur-Based Synthesis Techniques; Synthesis and biological activity
Source: ORCID
Added: August 5, 2023

2016 article

The De-Etiolated 1 Homolog of Arabidopsis Modulates the ABA Signaling Pathway and ABA Biosynthesis in Rice

Zang, G., Zou, H., Zhang, Y., Xiang, Z., Huang, J., Luo, L., … Wang, G. (2016, May 2). PLANT PHYSIOLOGY, Vol. 171, pp. 1259–1276.

By: G. Zang*, H. Zou*, Y. Zhang*, Z. Xiang*, J. Huang*, L. Luo*, C. Wang*, K. Lei* ...

Contributors: G. Zang*, H. Zou*, Y. Zhang*, Z. Xiang*, J. Huang*, L. Luo*, C. Wang*, K. Lei* ...

MeSH headings : Abscisic Acid / biosynthesis; Abscisic Acid / pharmacology; Arabidopsis Proteins / chemistry; Darkness; Etiolation / genetics; Gene Expression Profiling; Gene Expression Regulation, Plant / drug effects; Genetic Pleiotropy / drug effects; Germination / drug effects; Germination / genetics; Green Fluorescent Proteins / metabolism; Intracellular Signaling Peptides and Proteins; Multiprotein Complexes / metabolism; Nuclear Proteins / chemistry; Oryza / drug effects; Oryza / genetics; Oryza / metabolism; Plant Leaves / drug effects; Plant Leaves / genetics; Plant Proteins / genetics; Plant Proteins / metabolism; Plants, Genetically Modified; Protein Binding / drug effects; Proteolysis / drug effects; RNA Interference / drug effects; Seedlings / drug effects; Seedlings / genetics; Seedlings / growth & development; Sequence Homology, Amino Acid; Signal Transduction / drug effects; Signal Transduction / genetics; Stress, Physiological / drug effects; Stress, Physiological / genetics; Transcriptome / genetics
topics (OpenAlex): Plant Stress Responses and Tolerance; Plant Molecular Biology Research; Plant-Microbe Interactions and Immunity
TL;DR: The data suggest that OsDET1 plays an important role in maintaining normal development in rice and mediates the cross talk between ABA biosynthesis and ABA signaling pathways in rice. (via Semantic Scholar)
Source: ORCID
Added: August 5, 2023

Employment

Updated: August 5th, 2023 12:42

2023 - present

North Carolina State University Raleigh, North Carolina, US
Postdoctoral Fellow

2022 - 2023

University of Maryland Dental School Baltimore, MD, US
Postdoctoral Fellow Department of Microbial Pathogenesis

2022 - 2022

West China Hospital, Sichuan University Chengdu , Chengdu , CN
Postdoctoral Fellow Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.

2019 - 2022

Southwest Medical University Luzhou, Sichuan, CN
Scientific Researcher Drug Discovery Research Center

Education

Updated: September 1st, 2023 13:31

2015 - 2019

Chongqing University Chongqing, Shapingba/Chongqing, CN
PhD College of Bioengineering

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