Ahmad Ud Din
Also known as: Ahmad
Gut microbiome, IBD, Probiotics, miRNA, CVD, Atherosclerosis, Mice Model, DSS/TNBS, T2D
Focused Research is microbial consortia and relates them with different diseases and health conditions, which is specifically in line with my current research on colon cancer (colitis), diabetes and atherosclerosis using probiotics in mice models as well as some other related projects on the gut microbiome. Research keywords include Probiotics, Bifidobacterium, Lactobacillus Gut Microbiome, CVD, Diabetes, Colitis, Atherosclerosis, miRNA, Drugs, Antibiotic Resistance, Nutrients, Metabolism, and Metabolites (TMAO, Colibactin, Polyphenols, SCFA, Imidazole Propionate, AHL; AhR/IL-22).
Works (35)
Updated: April 22nd, 2024 07:45
2024 journal article
<i>Lacticaseibacillus</i><i>paracasei</i> BNCC345679 revolutionizes DSS-induced colitis and modulates gut microbiota
FRONTIERS IN MICROBIOLOGY, 15.
author keywords: DSS-induced colitis; dysbiosis; microRNA; gut microbiota; gut inflammation; probiotics; Lacticaseibacillus paracasei BNCC345679
www.frontiersin.org (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024
2024 journal article
Deciphering Microbiome, Transcriptome, and Metabolic Interactions in the Presence of Probiotic Lactobacillus acidophilus against Salmonella Typhimurium in a Murine Model
Antibiotics.
Source: ORCID
Added: April 15, 2024
2024 review
Mood and microbes: a comprehensive review of intestinal microbiota's impact on depression
[Review of ]. FRONTIERS IN PSYCHIATRY, 15.
author keywords: depressive disorder; gut microbiota; gut-brain axis (GBA); dysbiosis; metabolites; probiotics; prebiotics; FMT
TL;DR:
The results support the hypothesis that gut microbiota influences depression and provide a promising area of research for an improved knowledge of the etiology of the disease and future therapies.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2024 journal article
Novel Synergistic Probiotic Intervention: Transcriptomic and Metabolomic Analysis Reveals Ameliorative Effects on Immunity, Gut Barrier, and Metabolism of Mice during Salmonella typhimurium Infection
Genes.
TL;DR:
It is suggested that the administration of a probiotic mixture improves immunity, maintains gut homeostasis and barrier integrity, and enhances metabolism in Salmonella infection.
(via Semantic Scholar)
Source: ORCID
Added: April 1, 2024
2024 review
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder
[Review of ]. FRONTIERS IN IMMUNOLOGY, 15.
author keywords: CVD; HF; HTN; TMAO; SCFAs; FMT
TL;DR:
Current evidence highlighting the intricate links between gut microbiota, metabolites, and the development of CVD is compiled, focusing on how intestinal dysbiosis promotes CVD risk factors such as heart failure, hypertension, and atherosclerosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 19, 2024
2023 journal article
<i>Desulfovibrio desulfuricans</i> aggravates atherosclerosis by enhancing intestinal permeability and endothelial TLR4/NF-KB pathway in <i>Apoe-/-</i> mice
Genes & Diseases, 10.
Contributors: K. Zhang *, X. Qin, J. Qiu *, T. Sun *, K. Qu *, * , W. Yan *, T. Li*
TL;DR:
TAK-242, a specific inhibitor ofTLR4, can ameliorate the development of D. desulfuricans-induced atherosclerosis by blocking the LPS-induced activation of TLR4/NF-κB signaling.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2023 journal article
A narrative review: CXC chemokines influence immune surveillance in obesity and obesity-related diseases: Type 2 diabetes and nonalcoholic fatty liver disease
Reviews in Endocrine and Metabolic Disorders.
MeSH headings : Humans; Non-alcoholic Fatty Liver Disease / metabolism; Diabetes Mellitus, Type 2 / metabolism; Chemokines, CXC / metabolism; Obesity / metabolism; Insulin Resistance; Inflammation / metabolism; Liver / metabolism
TL;DR:
Because CXC chemokine profiling is strongly linked to leukocyte recruitment, macrophage recruitment, and immunomodulatory potential, it is hypothesize that it could be used to predict the therapeutic potential for obesity and obesity-related diseases (T2D and NAFLD).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2023 journal article
Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery
Frontiers in Cellular and Infection Microbiology, 12.
MeSH headings : Humans; Aged; Gastrointestinal Microbiome; Anti-Bacterial Agents / therapeutic use; Anti-Bacterial Agents / pharmacology; RNA, Ribosomal, 16S / genetics; Vitamin K 2 / pharmacology; Cardiac Surgical Procedures; Feces / microbiology
TL;DR:
The composition of the gut microbiota had a significant change post-intravenous antibiotics treatment in cardiac surgery patients, and the richness and diversity of gut microbiota are increased in elderly patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 6, 2023
2023 journal article
Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota
Biomedicine &Amp; Pharmacotherapy, 161, 114562.
TL;DR:
Results showed that doses of PFOS alleviated the DSS-induced histopathological damage and improved intestinal barrier function, suggesting that PFOS might be used as an efficacious supplement for reducing inflammatory bowel disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 6, 2023
2023 journal article
Translational informatics for human microbiota: data resources, models and applications
Briefings in Bioinformatics, 24(3).
TL;DR:
A landscape of the data resources, a comparison of the computational models and a summary of the translational informatics applied to microbiota data, including biomarker discovery, personalized treatment and smart healthcare for complex diseases are provided.
(via Semantic Scholar)
Source: ORCID
Added: August 6, 2023
2022 journal article
Emerging Piezo1 signaling in inflammation and atherosclerosis; a potential therapeutic target
International Journal of Biological Sciences.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2022 journal article
Evaluation of Cardiac Biomarkers and Expression Analysis of IL-1, IL-6, IL-10, IL-17, and IL-25 among COVID-19 Patients from Pakistan
Viruses.
MeSH headings : Humans; COVID-19; SARS-CoV-2; Interleukin-6; Interleukin-10; Interleukin-17 / genetics; Pakistan; Biomarkers; Cytokines; Troponin; Interleukin-1
TL;DR:
It is concluded that the evaluation of cardiac biomarkers with cytokine storm plays a significant role in COVID-19-associated anatomical organ damage, myocardial injury, and mortality and Physicians should pay special attention to cardiac biomarker in patients with old age, inflammation, and comorbidities among CO VID-19 infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2022 journal article
Isolation, characterization, bacteriocin production and biological potential of Bifidobacteria of ruminants
Analytical Biochemistry, 658, 114926.
MeSH headings : Animals; Acrylamides; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / chemistry; Bacteriocins / pharmacology; Bacteriocins / chemistry; Bifidobacterium; Edetic Acid; Escherichia coli; Glucose; Hydrogen-Ion Concentration; Ruminants / microbiology; Sodium Chloride; Sodium Dodecyl Sulfate; Staphylococcus aureus; Urea
TL;DR:
It is indicated that bifidobacterial bacteriocins have considerable potential to be used as biopreservative.
(via Semantic Scholar)
Source: ORCID
Added: August 6, 2023
2022 journal article
Metagenomic Analysis of Liquor Starter Culture Revealed Beneficial Microbes’ Presence
Foods.
TL;DR:
This study identified beneficial microbes in the starter culture of Zaopei Baijiu Daqu (ZBD) starter cultures, opening a path for further in-depth analysis of those microbes by isolating and evaluating them for a valuable role in in vitro and in vivo studies.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2022 journal article
Seroprevalence of Anti-tTg-IgA among Symptomized Celiac Disease Patients and Their Correlation with Rotavirus Infection
BioMed Research International.
Ed(s): H. Pan
MeSH headings : Adolescent; Autoantibodies; Celiac Disease / epidemiology; Child; Child, Preschool; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Glutens; Humans; Immunoglobulin A / analysis; Rotavirus Infections / epidemiology; Seroepidemiologic Studies; Transglutaminases
TL;DR:
The study findings demonstrate that Pakistan has a high prevalence of CD compared to other studies, and further studies in the fields of environmental risk factors and treatment with more advanced serological and histopathological studies are needed in the future.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2021 journal article
Analyzing differentially expressed genes and pathways of Bex2-deficient mouse lung via RNA-Seq
Turkish Journal of Biology.
Contributors: N. Bahadar *, H. Ullah *, S. Adlat*, R. Kumar Sah*, M. Zun Zaw Myint*, Z. Mar Oo*, F. Binta Bah*, F. Hayel Nagi*
TL;DR:
According to gene enrichment analysis, PPAR pathway, cardiac muscle contraction, and cytokine-cytokine receptor interaction were the most enriched pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2021 journal article
Co-infections of two carbapenemase-producing <i>Enterobacter hormaechei</i> clinical strains isolated from the same diabetes individual in China
Journal of Medical Microbiology.
TL;DR:
This study reveals two multiple drug-resistant E. hormaechei isolates from diabetes patient samples, which were isolated from a patient with diabetes in Sichuan, China and were resistant to carbapenems, β-lactam, aminoglycoside, quinolone and tetracycline.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2021 journal article
Complete genome sequence and probiotic properties of <italic>Lactococcus petauri</italic> LZys1 isolated from healthy human gut
Journal of Medical Microbiology, 70(8).
Contributors: O. Li *, H. Zhang*, W. Wang *, Y. Liang *, W. Chen*, A. Ud Din *, L. Li *, Y. Zhou *
MeSH headings : Animals; Bacteria / growth & development; Bacteria / pathogenicity; Base Sequence; Feces / microbiology; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Lactococcus / cytology; Lactococcus / genetics; Lactococcus / isolation & purification; Lactococcus / physiology; Male; Molecular Sequence Annotation; Moths / microbiology; Phylogeny; Polysaccharides, Bacterial / biosynthesis; Polysaccharides, Bacterial / genetics; Probiotics; Whole Genome Sequencing; Young Adult
TL;DR:
All the results described in this study, together with relevant information previously reported, made L. prtauri LZys1 a very interesting potential strain to be considered as a prominent candidate for probiotic use.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2021 journal article
Gut microbiome colonization and development in neonatal ruminants: Strategies, prospects, and opportunities
Animal Nutrition.
TL;DR:
All the possible factors, which can influence rumen microbiome colonization and development, are explored and the advantages and disadvantages of potential strategies used to manipulate gut development and microbial colonization to improve the production and health of newborn calves at an early age when they are most susceptible to enteric disease are discussed.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2021 journal article
Implication of ferroptosis in aging
Cell Death Discovery.
TL;DR:
The factual evidences to support the possible role and implication of ferroptosis in aging are highlighted in order to declare the need to identify and explore the interventions to prevent excessive ferroPTosis leading to accelerated aging and associated liabilities of aging.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2021 journal article
Microbiota Targeted Interventions of Probiotic <i>Lactobacillus</i> as an Anti-Ageing Approach: A Review
Antioxidants.
TL;DR:
The role of Lactobacillus strains in restoration of gut microbiota dysbiosis and alleviating certain conditions during ageing is highlighted and its inherent effects against age-related oxidative stress as well as on the gut health and gut-brain axis are discussed.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2020 journal article
Anti-atherosclerotic effects of Lactobacillus plantarum ATCC 14917 in ApoE−/− mice through modulation of proinflammatory cytokines and oxidative stress
Applied Microbiology and Biotechnology.
TL;DR:
Results showed that L. plantarum ATCC 14917 supplementation decreases the progression of atherosclerotic lesion formation by alleviating the inflammatory process and lowering oxidative stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2020 journal article
Application of a Faecalibacterium 16S rDNA genetic marker for species identification of dog fecal waste
Environmental Science and Pollution Research.
Source: ORCID
Added: August 5, 2023
2020 journal article
Bacterial association and comparison between lung and intestine in rats
Bioscience Reports, 40(4).
Contributors: T. Liu *, C. Zhang *, * , N. Li *, Q. Wang *, J. Yu*, Z. Xu*, C. Li *
MeSH headings : Animals; Bacteria / genetics; Bacteria / immunology; DNA, Bacterial / isolation & purification; Feces / microbiology; Gastrointestinal Microbiome / genetics; Lung / microbiology; Male; Models, Animal; Phylogeny; RNA, Ribosomal, 16S / genetics; Rats; Rats, Wistar; Sequence Analysis, DNA; Specific Pathogen-Free Organisms
TL;DR:
It was found that intestine bacteria was more abundant and diverse than lung bacteria, and intestine bacteria were enriched in RNA processing, modification chromatin structure, dynamics and amino acid metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2020 journal article
High incidence and characteristic of PRRSV and resistant bacterial Co-Infection in pig farms
Microbial Pathogenesis, 149, 104536.
Contributors: X. Yan*, J. Zeng *, X. Li *, Z. Zhang *, * , K. Zhao *, Y. Zhou *
TL;DR:
Co-infection is common in pig farms and the orf5 gene continues to undergo its sequences divergence, and continuous study of the characteristic of PRRSV and resistant bacterial co- Infection is necessary for healthy pig aquaculture.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2020 journal article
Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism
Journal of Nutritional Biochemistry, 79.
Contributors: * , A. Hassan*, Y. Zhu *, K. Zhang *, Y. Wang *, T. Li*, Y. Wang *, G. Wang*
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Antioxidants / pharmacology; Bifidobacterium bifidum; Colitis, Ulcerative / chemically induced; Colitis, Ulcerative / drug therapy; Colitis, Ulcerative / metabolism; Colon / metabolism; Cytokines / metabolism; Dextran Sulfate / adverse effects; Disease Models, Animal; Dysbiosis / chemically induced; Dysbiosis / drug therapy; Gastrointestinal Microbiome / drug effects; Interleukin-1beta / metabolism; Male; Mice; Mice, Inbred C57BL; MicroRNAs / metabolism; NF-kappa B / metabolism; Probiotics / administration & dosage; Probiotics / pharmacology; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The probiotic strain B. bifidum ATCC 29521 exhibited its probiotic role through its anti-inflammatory role by modulating miRNA-associated TJP and NF-κB regulation and by partially restoring dysbiosis in the DSS colitis mouse model.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2020 journal article
SARS-CoV-2 Microbiome Dysbiosis Linked Disorders and Possible Probiotics Role
Biomedicine & Pharmacotherapy, 11, 110947.
TL;DR:
It is concluded that dysbiosis occurs during SARS-COV-2 infection as the gut-lung axis cannot be ignored and the inclusion of studies to investigate gut microbiome and subsequent therapies such as probiotics might help decrease the inflammatory response of viral pathogenesis and respiratory symptoms by strengthening the host immune system, amelioration of gut microbiome, and improvement of gut barrier function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2020 journal article
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 11. http://europepmc.org/abstract/PMC/PMC7657099
Source: ORCID
Added: August 5, 2023
2020 journal article
The Role of Agriculture in the Dissemination of Class 1 Integrons, Antimicrobial Resistance, and Diversity of Their Gene Cassettes in Southern China
Genes, 11(9), 1014.
TL;DR:
This study highlights the significant differences in the abundance of integrons among various agricultural soils and offers deep insight into the pools of gene cassettes that play a key role in the dissemination ofIntegrons and AMR.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2019 journal article
Amelioration of TMAO through probiotics and its potential role in atherosclerosis
Applied Microbiology and Biotechnology, 103(23-24), 9217–9228.
Contributors: * , A. Hassan*, Y. Zhu *, T. Yin*, H. Gregersen * & G. Wang*
MeSH headings : Animals; Atherosclerosis / physiopathology; Atherosclerosis / prevention & control; Humans; Metabolomics; Methylamines / antagonists & inhibitors; Methylamines / metabolism; Mice; MicroRNAs; Microbiota; Probiotics / therapeutic use
TL;DR:
Advances in TMAO preventing strategies through probiotics, including, modulation of gut microbiome, metabolomics profile, miRNA, or probiotic antagonistic abilities, are focused on.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2019 journal article
Beneficial effects of Enterococcus faecalis in hypercholesterolemic mice on cholesterol transportation and gut microbiota
Applied Microbiology and Biotechnology, 103(7), 3181–3191.
MeSH headings : ATP Binding Cassette Transporter, Subfamily G, Member 5 / genetics; ATP Binding Cassette Transporter, Subfamily G, Member 8 / genetics; Administration, Oral; Animals; Bifidobacterium / isolation & purification; Biological Transport; Cholesterol / blood; Cholesterol / metabolism; Enterococcus faecalis / metabolism; Gastrointestinal Microbiome; Hypercholesterolemia / therapy; Lactobacillus / isolation & purification; Lipid Metabolism; Lipoproteins / genetics; Liver / metabolism; Male; Mice; Mice, Inbred C57BL; Microbial Interactions
TL;DR:
E. faecalis ATCC19433 maybe contribute to the transportation of cholesterol potentially and modulate the composition of gut microbiota and increased the counts of Lactobacillus, Bifidobacterium, and Akkermansia in hypercholesterolemic mice.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2019 journal article
Effect of simulated microgravity induced PI3K-nos2b signalling on zebrafish cardiovascular plexus network formation
Journal of Biomechanics, 87, 83–92.
Contributors: X. Xie, D. Lei*, Q. Zhang *, Y. Wang *, L. Wen *, Z. Ye *, A. Ud Din *, D. Jia *, A. Apicella *, G. Wang
MeSH headings : Animals; Cardiovascular Physiological Phenomena; Embryo, Nonmammalian; Morphogenesis; Neovascularization, Physiologic / physiology; Nitric Oxide / metabolism; Nitric Oxide Synthase Type II / metabolism; Phosphatidylinositol 3-Kinase / metabolism; Signal Transduction / physiology; Weightlessness; Zebrafish / embryology
TL;DR:
It can be concluded that SM affects zebrafish CVP network remodeling by enhancing angiogenesis and the PI3K-nos2b signaling pathway is involved in this process.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
2019 journal article
Updates in understanding the hypocholesterolemia effect of probiotics on atherosclerosis
Applied Microbiology and Biotechnology, 103(15), 5993–6006.
Contributors: A. Hassan*, * , Y. Zhu *, K. Zhang *, T. Li*, Y. Wang *, Y. Luo *, G. Wang*
MeSH headings : Animals; Atherosclerosis / physiopathology; Atherosclerosis / prevention & control; Cholesterol / metabolism; Humans; Hypercholesterolemia / complications; Hypercholesterolemia / therapy; Probiotics / administration & dosage; Probiotics / pharmacology
TL;DR:
The aim of this review is to explore the hypercholesterolemia effect of how it progresses into atherosclerosis and to summarize the hypocholesterolaemia effect of probiotics on atheros sclerosis and the up-to-date information on their basic mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: August 5, 2023
2018 journal article
An overview on the progress and development on metals/non-metal catalyzed cyanation reactions
Inorganica Chimica Acta, 469, 408–423.
Contributors: T. Najam *, S. Shah *, K. Mehmood*, * , S. Rizwan*, M. Ashfaq *, S. Shaheen*, A. Waseem *
Source: ORCID
Added: August 5, 2023
2016 journal article
The de-etiolated 1 homolog of arabidopsis modulates the ABA signaling pathway and ABA biosynthesis in rice
Plant Physiology, 171(2), 1259–1276.
Contributors: G. Zang *, H. Zou*, Y. Zhang *, Z. Xiang *, J. Huang *, L. Luo *, C. Wang *, K. Lei*
TL;DR:
The data suggest that OsDET1 plays an important role in maintaining normal development in rice and mediates the cross talk between ABA biosynthesis and ABA signaling pathways in rice.
(via Semantic Scholar)
Source: ORCID
Added: August 5, 2023
Employment
Updated: August 5th, 2023 12:42
2023 - present
North Carolina State University Raleigh, North Carolina, US
Postdoctoral Fellow
2022 - 2023
University of Maryland Dental School Baltimore, MD, US
Postdoctoral Fellow
Department of Microbial Pathogenesis
2022 - 2022
West China Hospital, Sichuan University Chengdu , Chengdu , CN
Postdoctoral Fellow
Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
2019 - 2022
Southwest Medical University Luzhou, Sichuan, CN
Scientific Researcher
Drug Discovery Research Center
Education
Updated: September 1st, 2023 13:31
2015 - 2019
Chongqing University Chongqing, Shapingba/Chongqing, CN
PhD
College of Bioengineering
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