Ashley Carson Brown

Works (58)

2022 article

Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype

Chester, D., Lee, V., Wagner, P., Nordberg, M., Fisher, M. B., & Brown, A. C. (2022, February 1). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.

By: D. Chester, V. Lee, P. Wagner, M. Nordberg, M. Fisher & A. Brown

Source: Web Of Science
Added: February 7, 2022

2022 article

Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages

Nellenbach, K., & Brown, A. C. (2022, April 19). JOURNAL OF THROMBOSIS AND HAEMOSTASIS.

By: K. Nellenbach & A. Brown

Source: Web Of Science
Added: May 2, 2022

2022 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

ACTA BIOMATERIALIA.

By: C. Moody, A. Brown, N. Massaro, A. Patel, P. Agarwalla, A. Simpson, A. Brown, H. Zheng, J. Pierce, Y. Brudno

Source: Web Of Science
Added: January 18, 2022

2021 journal article

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

BLOOD ADVANCES.

By: K. Nellenbach, A. Kyu, N. Guzzetta & A. Brown

Source: Web Of Science
Added: January 3, 2022

2021 journal article

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation

BLOOD ADVANCES, 5(3), 613–627.

By: E. Mihalko, M. Sandry, N. Mininni, K. Nellenbach, H. Deal, M. Daniele, K. Ghadimi, J. Levy, A. Brown

Source: Web Of Science
Added: March 22, 2021

2021 article

Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo

Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). BIOENGINEERING & TRANSLATIONAL MEDICINE.

Source: Web Of Science
Added: December 20, 2021

2021 journal article

Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing

BULLETIN OF MATHEMATICAL BIOLOGY, 83(5).

Source: Web Of Science
Added: March 29, 2021

2021 article

Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents

Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21). ADVANCED HEALTHCARE MATERIALS.

By: A. Krissanaprasit, C. Key, K. Froehlich, S. Pontula, E. Mihalko, D. Dupont, E. Andersen, J. Kjems, A. Brown, T. LaBean

Source: Web Of Science
Added: June 10, 2021

2021 review

Neonatal coagulopathies: A review of established and emerging treatments

[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE.

By: N. Moiseiwitsch & A. Brown

Source: Web Of Science
Added: July 12, 2021

2021 article

Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury

Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: J. Todd, V. Bharadwaj, K. Nellenbach, S. Nandi, E. Mihalko, C. Copeland, A. Brown, S. Stabenfeldt

Source: Web Of Science
Added: June 21, 2021

2021 journal article

Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses

COLLOIDS AND SURFACES B-BIOINTERFACES.

Source: Web Of Science
Added: July 19, 2021

2021 article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

ADVANCED THERAPEUTICS.

By: S. Nandi, E. Mihalko, K. Nellenbach, M. Castaneda, J. Schneible, M. Harp, H. Deal, M. Daniele ...

Source: Web Of Science
Added: April 5, 2021

2020 review

Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria

[Review of ]. BIOMATERIALS SCIENCE, 8(4), 1089–1100.

By: E. Chee & A. Brown

Source: Web Of Science
Added: March 16, 2020

2020 review

Clot Structure and Implications for Bleeding and Thrombosis

[Review of ]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104.

By: E. Mihalko & A. Brown

Source: Web Of Science
Added: February 27, 2020

2020 journal article

Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(3), 299–309.

By: E. Sproul, S. Nandi, E. Chee, S. Sivadanam, B. Igo, L. Schreck, A. Brown

Source: Web Of Science
Added: October 12, 2020

2020 review

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 8(32), 7062–7075.

By: H. Deal, A. Brown & M. Daniele

Source: Web Of Science
Added: September 7, 2020

2020 article

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: E. Chee, S. Nandi, K. Nellenbach, E. Mihalko, D. Snider, L. Morrill, A. Bond, E. Sproul ...

Source: Web Of Science
Added: March 16, 2020

2020 article

Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds

CELLULAR AND MOLECULAR BIOENGINEERING.

By: K. Nellenbach, S. Nandi, C. Peeler, A. Kyu & A. Brown

Source: Web Of Science
Added: June 15, 2020

2020 journal article

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.

By: S. Nandi, L. Sommerville, K. Nellenbach, E. Mihalko, M. Erb, D. Freytes, M. Hoffman, D. Monroe, A. Brown

Source: Web Of Science
Added: August 24, 2020

2020 journal article

Ultrasonic Microplotting of Microgel Bioinks

ACS APPLIED MATERIALS & INTERFACES, 12(42), 47309–47319.

By: D. Chester, P. Theetharappan, T. Ngobili, M. Daniele & A. Brown

Source: Web Of Science
Added: December 21, 2020

2020 journal article

Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 3026–3036.

Source: Web Of Science
Added: June 8, 2020

2019 review

Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen

[Review of ]. BIOCONJUGATE CHEMISTRY, 30(7), 1951–1956.

By: A. Brown, E. Lavik & S. Stabenfeldt

Source: Web Of Science
Added: August 12, 2019

2019 journal article

Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate

ACS APPLIED MATERIALS & INTERFACES, 11(4), 3771–3780.

By: I. Muhamed, E. Sproul, F. Ligler & A. Brown

Source: NC State University Libraries
Added: February 18, 2019

2019 article

Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation

Brown, A. C., & Levy, J. H. (2019, September). ANESTHESIOLOGY, Vol. 131, pp. 459–461.

By: A. Brown & J. Levy

Source: Web Of Science
Added: September 23, 2019

2019 article

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

CONNECTIVE TISSUE RESEARCH.

By: P. Huebner, P. Warren, D. Chester, J. Spang, A. Brown, M. Fisher, R. Shirwaiker

Source: Web Of Science
Added: August 26, 2019

2019 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

BIOMATERIALS SCIENCE, 7(2), 669–682.

Source: NC State University Libraries
Added: February 18, 2019

2019 article

Wound Healing and the Host Response in Regenerative Engineering

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.

By: D. Chester, E. Marrow, M. Daniele & A. Brown

Source: Web Of Science
Added: April 14, 2020

2018 journal article

Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes

ADVANCED BIOSYSTEMS, 2(10).

By: E. Sproul, S. Nandi, C. Roosa, L. Schreck & A. Brown

Source: NC State University Libraries
Added: October 29, 2018

2018 journal article

Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels

Colloids and Surfaces. B, Biointerfaces, 166, 89–97.

By: N. Welsch, A. Brown, T. Barker & L. Lyon

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Fibrin biomaterials for tissue regeneration and repair

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair, 151–173.

By: E. Sproul, S. Nandi & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo

LAB ON A CHIP, 18(19), 2985–2993.

By: E. Hardy, Y. Wang, S. Iyer, R. Mannino, Y. Sakurai, T. Barker, T. Chi, Y. Youn ...

Source: NC State University Libraries
Added: November 19, 2018

2018 review

Material strategies for modulating epithelial to mesenchymal transitions

[Review of ]. ACS Biomaterials-Science & Engineering, 4(4), 1149–1161.

By: E. Mihalko & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Study of poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) microgel particle induced deformations of tissue-mimicking phantom by ultrasound stimulation

Langmuir, 34(4), 1457–1465.

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

By: E. Mihalko, K. Huang, E. Sproul, K. Cheng & A. Brown

Source: Crossref
Added: November 29, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

By: J. Tang, T. Su, K. Huang, P. Dinh, Z. Wang, A. Vandergriff, M. Hensley, J. Cores ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

BIOMATERIALS, 185, 371–382.

By: D. Chester, R. Kathard, J. Nortey, K. Nellenbach & A. Brown

Source: NC State University Libraries
Added: November 12, 2018

2017 journal article

Characterizing cell migration within three-dimensional in vitro wound environments

Jove-Journal of Visualized Experiments, (126).

By: S. Nandi & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Detection of an integrin-binding mechanoswitch within fibronectin during tissue formation and fibrosis

ACS Nano, 11(7), 7110–7117.

By: L. Cao, J. Nicosia, J. Larouche, Y. Zhang, H. Bachman, A. Brown, L. Holmgren, T. Barker

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Peptide mimetic drugs for modulating thrombosis and hemostasis

Drug Development Research, 78(6), 236–244.

By: K. Nellenbach & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Single-platelet nanomechanics measured by high-throughput cytometry

Nature Materials, 16(2), 230–235.

By: D. Myers, Y. Qiu, M. Fay, M. Tennenbaum, D. Chester, J. Cuadrado, Y. Sakurai, J. Baek ...

Source: NC State University Libraries
Added: August 6, 2018

2017 review

The role of biophysical properties of provisional matrix proteins in wound repair

[Review of ]. Matrix biology, 60-61, 124–140.

By: D. Chester & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Fibrin network changes in neonates after cardiopulmonary bypass

Anesthesiology, 124(5), 1021–1031.

By: A. Brown, R. Hannan, L. Timmins, J. Fernandez, T. Barker & N. Guzzetta

Source: NC State University Libraries
Added: August 6, 2018

2016 review

Platelet-mimetic strategies for modulating the wound environment and inflammatory responses

[Review of ]. Experimental Biology and Medicine, 241(10), 1138–1148.

By: S. Nandi & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Chondroitin sulfate glycosaminoglycan hydrogels create endogenous niches for neural stem cells

Bioconjugate Chemistry, 26(12), 2336–2349.

By: L. Karumbaiah, S. Enam, A. Brown, T. Saxena, M. Betancur, T. Barker, R. Bellamkonda

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Integrin alpha 3 beta 1 binding to fibronectin is dependent on the ninth type III repeat

Journal of Biological Chemistry, 290(42), 25534–25547.

By: A. Brown, M. Dysart, K. Clarke, S. Stabenfeldt & T. Barker

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties

Biomaterials, 49, 27–36.

By: A. Brown, S. Baker, A. Douglas, M. Keating, M. Alvarez-Elizondo, E. Botvinick, M. Guthold, T. Barker

Source: Crossref
Added: August 16, 2021

2015 journal article

Ultrasoft, highly deformable microgels

Soft Matter, 11(10), 2018–2028.

By: H. Bachman, A. Brown, K. Clarke, K. Dhada, A. Douglas, C. Hansen, E. Herman, J. Hyatt ...

Source: Crossref
Added: August 16, 2021

2014 journal article

Direct observation of ligand-induced receptor dimerization with a bioresponsive hydrogel

RSC Advances, 4(110), 65173–65175.

By: J. Kim, Y. Park, A. Brown & L. Lyon

Source: Crossref
Added: October 23, 2021

2014 journal article

Fibrin Fibers: Blocking the B:B Knob-Pocket Interaction

Biophysical Journal, 106(2), 614a.

By: S. Baker, A. Carson-Brown, M. Guthold & T. Barker

Source: Crossref
Added: October 23, 2021

2014 journal article

Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level

Acta Biomaterialia, 10(4), 1502–1514.

By: A. Brown & T. Barker

Source: Crossref
Added: August 16, 2021

2014 journal article

Learning from nature – Novel synthetic biology approaches for biomaterial design

Acta Biomaterialia, 10(4), 1761–1769.

By: A. Bryksin, A. Brown, M. Baksh, M. Finn & T. Barker

Source: Crossref
Added: October 23, 2021

2014 journal article

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

Proceedings of the National Academy of Sciences, 111(40), 14430–14435.

By: Y. Qiu, A. Brown, D. Myers, Y. Sakurai, R. Mannino, R. Tran, B. Ahn, E. Hardy ...

Source: Crossref
Added: October 23, 2021

2014 journal article

Ultrasoft microgels displaying emergent platelet-like behaviours

Nature Materials, 13(12), 1108–1114.

By: A. Brown, S. Stabenfeldt, B. Ahn, R. Hannan, K. Dhada, E. Herman, V. Stefanelli, N. Guzzetta ...

Source: Crossref
Added: October 23, 2021

2013 journal article

Colloid-matrix assemblies in regenerative medicine

Current Opinion in Colloid & Interface Science, 18(5), 393–405.

By: K. Clarke, A. Douglas, A. Brown, T. Barker & L. Lyon

Source: Crossref
Added: October 23, 2021

2013 journal article

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

The Journal of Pathology, 229(1), 25–35.

By: A. Brown, V. Fiore, T. Sulchek & T. Barker

Source: Crossref
Added: October 23, 2021

2013 journal article

The Mechanical Properties of Modified Fibrin Fibers: Blocking the B-b Knob-Pocket Interaction

Biophysical Journal, 104(2), 512a–513a.

By: S. Baker, A. Carson Brown, T. Barker & M. Guthold

Source: Crossref
Added: October 23, 2021

2012 journal article

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

Journal of Biomedical Materials Research Part A, 100A(8), 2119–2127.

By: M. Markowski, A. Brown & T. Barker

Source: Crossref
Added: October 23, 2021

2010 journal article

Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals

Lab Chip, 10(5), 571–580.

By: E. Park, A. Brown, M. DiFeo, T. Barker & H. Lu

Source: Crossref
Added: October 23, 2021