Ashley Carson Brown

Works (53)

2021 journal article

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation

BLOOD ADVANCES, 5(3), 613–627.

By: E. Mihalko, M. Sandry, N. Mininni, K. Nellenbach, H. Deal, M. Daniele, K. Ghadimi, J. Levy, A. Brown

Source: Web Of Science
Added: March 22, 2021

2021 journal article

Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing

BULLETIN OF MATHEMATICAL BIOLOGY, 83(5).

Source: Web Of Science
Added: March 29, 2021

2021 article

Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents

Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21). ADVANCED HEALTHCARE MATERIALS.

By: A. Krissanaprasit, C. Key, K. Froehlich, S. Pontula, E. Mihalko, D. Dupont, E. Andersen, J. Kjems, A. Brown, T. LaBean

Source: Web Of Science
Added: June 10, 2021

2021 review

Neonatal coagulopathies: A review of established and emerging treatments

[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE.

By: N. Moiseiwitsch & A. Brown

Source: Web Of Science
Added: July 12, 2021

2021 article

Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury

Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: J. Todd, V. Bharadwaj, K. Nellenbach, S. Nandi, E. Mihalko, C. Copeland, A. Brown, S. Stabenfeldt

Source: Web Of Science
Added: June 21, 2021

2021 journal article

Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses

COLLOIDS AND SURFACES B-BIOINTERFACES.

Source: Web Of Science
Added: July 19, 2021

2021 article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

ADVANCED THERAPEUTICS.

By: S. Nandi, E. Mihalko, K. Nellenbach, M. Castaneda, J. Schneible, M. Harp, H. Deal, M. Daniele ...

Source: Web Of Science
Added: April 5, 2021

2020 review

Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria

[Review of ]. BIOMATERIALS SCIENCE, 8(4), 1089–1100.

By: E. Chee & A. Brown

Source: Web Of Science
Added: March 16, 2020

2020 review

Clot Structure and Implications for Bleeding and Thrombosis

[Review of ]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104.

By: E. Mihalko & A. Brown

Source: Web Of Science
Added: February 27, 2020

2020 journal article

Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(3), 299–309.

By: E. Sproul, S. Nandi, E. Chee, S. Sivadanam, B. Igo, L. Schreck, A. Brown

Source: Web Of Science
Added: October 12, 2020

2020 review

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 8(32), 7062–7075.

By: H. Deal, A. Brown & M. Daniele

Source: Web Of Science
Added: September 7, 2020

2020 article

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: E. Chee, S. Nandi, K. Nellenbach, E. Mihalko, D. Snider, L. Morrill, A. Bond, E. Sproul ...

Source: Web Of Science
Added: March 16, 2020

2020 article

Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds

CELLULAR AND MOLECULAR BIOENGINEERING.

By: K. Nellenbach, S. Nandi, C. Peeler, A. Kyu & A. Brown

Source: Web Of Science
Added: June 15, 2020

2020 journal article

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.

By: S. Nandi, L. Sommerville, K. Nellenbach, E. Mihalko, M. Erb, D. Freytes, M. Hoffman, D. Monroe, A. Brown

Source: Web Of Science
Added: August 24, 2020

2020 journal article

Ultrasonic Microplotting of Microgel Bioinks

ACS APPLIED MATERIALS & INTERFACES, 12(42), 47309–47319.

By: D. Chester, P. Theetharappan, T. Ngobili, M. Daniele & A. Brown

Source: Web Of Science
Added: December 21, 2020

2020 journal article

Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 3026–3036.

Source: Web Of Science
Added: June 8, 2020

2019 review

Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen

[Review of ]. BIOCONJUGATE CHEMISTRY, 30(7), 1951–1956.

By: A. Brown, E. Lavik & S. Stabenfeldt

Source: Web Of Science
Added: August 12, 2019

2019 journal article

Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate

ACS APPLIED MATERIALS & INTERFACES, 11(4), 3771–3780.

By: I. Muhamed, E. Sproul, F. Ligler & A. Brown

Source: NC State University Libraries
Added: February 18, 2019

2019 article

Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation

Brown, A. C., & Levy, J. H. (2019, September). ANESTHESIOLOGY, Vol. 131, pp. 459–461.

By: A. Brown & J. Levy

Source: Web Of Science
Added: September 23, 2019

2019 article

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

CONNECTIVE TISSUE RESEARCH.

By: P. Huebner, P. Warren, D. Chester, J. Spang, A. Brown, M. Fisher, R. Shirwaiker

Source: Web Of Science
Added: August 26, 2019

2019 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

BIOMATERIALS SCIENCE, 7(2), 669–682.

Source: NC State University Libraries
Added: February 18, 2019

2019 article

Wound Healing and the Host Response in Regenerative Engineering

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.

By: D. Chester, E. Marrow, M. Daniele & A. Brown

Source: Web Of Science
Added: April 14, 2020

2018 journal article

Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes

ADVANCED BIOSYSTEMS, 2(10).

By: E. Sproul, S. Nandi, C. Roosa, L. Schreck & A. Brown

Source: NC State University Libraries
Added: October 29, 2018

2018 journal article

Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels

Colloids and Surfaces. B, Biointerfaces, 166, 89–97.

By: N. Welsch, A. Brown, T. Barker & L. Lyon

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Fibrin biomaterials for tissue regeneration and repair

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair, 151–173.

By: E. Sproul, S. Nandi & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo

LAB ON A CHIP, 18(19), 2985–2993.

By: E. Hardy, Y. Wang, S. Iyer, R. Mannino, Y. Sakurai, T. Barker, T. Chi, Y. Youn ...

Source: NC State University Libraries
Added: November 19, 2018

2018 review

Material strategies for modulating epithelial to mesenchymal transitions

[Review of ]. ACS Biomaterials-Science & Engineering, 4(4), 1149–1161.

By: E. Mihalko & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Study of poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) microgel particle induced deformations of tissue-mimicking phantom by ultrasound stimulation

Langmuir, 34(4), 1457–1465.

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

By: E. Mihalko, K. Huang, E. Sproul, K. Cheng & A. Brown

Source: Crossref
Added: November 29, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

By: J. Tang, T. Su, K. Huang, P. Dinh, Z. Wang, A. Vandergriff, M. Hensley, J. Cores ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

BIOMATERIALS, 185, 371–382.

By: D. Chester, R. Kathard, J. Nortey, K. Nellenbach & A. Brown

Source: NC State University Libraries
Added: November 12, 2018

2017 journal article

Characterizing cell migration within three-dimensional in vitro wound environments

Jove-Journal of Visualized Experiments, (126).

By: S. Nandi & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Detection of an integrin-binding mechanoswitch within fibronectin during tissue formation and fibrosis

ACS Nano, 11(7), 7110–7117.

By: L. Cao, J. Nicosia, J. Larouche, Y. Zhang, H. Bachman, A. Brown, L. Holmgren, T. Barker

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Peptide mimetic drugs for modulating thrombosis and hemostasis

Drug Development Research, 78(6), 236–244.

By: K. Nellenbach & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Single-platelet nanomechanics measured by high-throughput cytometry

Nature Materials, 16(2), 230–235.

By: D. Myers, Y. Qiu, M. Fay, M. Tennenbaum, D. Chester, J. Cuadrado, Y. Sakurai, J. Baek ...

Source: NC State University Libraries
Added: August 6, 2018

2017 review

The role of biophysical properties of provisional matrix proteins in wound repair

[Review of ]. Matrix biology, 60-61, 124–140.

By: D. Chester & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Fibrin network changes in neonates after cardiopulmonary bypass

Anesthesiology, 124(5), 1021–1031.

By: A. Brown, R. Hannan, L. Timmins, J. Fernandez, T. Barker & N. Guzzetta

Source: NC State University Libraries
Added: August 6, 2018

2016 review

Platelet-mimetic strategies for modulating the wound environment and inflammatory responses

[Review of ]. Experimental Biology and Medicine, 241(10), 1138–1148.

By: S. Nandi & A. Brown

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Chondroitin sulfate glycosaminoglycan hydrogels create endogenous niches for neural stem cells

Bioconjugate Chemistry, 26(12), 2336–2349.

By: L. Karumbaiah, S. Enam, A. Brown, T. Saxena, M. Betancur, T. Barker, R. Bellamkonda

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Integrin alpha 3 beta 1 binding to fibronectin is dependent on the ninth type III repeat

Journal of Biological Chemistry, 290(42), 25534–25547.

By: A. Brown, M. Dysart, K. Clarke, S. Stabenfeldt & T. Barker

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties

Biomaterials, 49, 27–36.

By: A. Brown, S. Baker, A. Douglas, M. Keating, M. Alvarez-Elizondo, E. Botvinick, M. Guthold, T. Barker

Source: Crossref
Added: August 16, 2021

2015 journal article

Ultrasoft, highly deformable microgels

Soft Matter, 11(10), 2018–2028.

By: H. Bachman, A. Brown, K. Clarke, K. Dhada, A. Douglas, C. Hansen, E. Herman, J. Hyatt ...

Source: Crossref
Added: August 16, 2021

2014 journal article

Direct observation of ligand-induced receptor dimerization with a bioresponsive hydrogel

RSC Advances, 4(110), 65173–65175.

By: J. Kim, Y. Park, A. Brown & L. Lyon

Source: Crossref
Added: October 23, 2021

2014 journal article

Fibrin Fibers: Blocking the B:B Knob-Pocket Interaction

Biophysical Journal, 106(2), 614a.

By: S. Baker, A. Carson-Brown, M. Guthold & T. Barker

Source: Crossref
Added: October 23, 2021

2014 journal article

Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level

Acta Biomaterialia, 10(4), 1502–1514.

By: A. Brown & T. Barker

Source: Crossref
Added: August 16, 2021

2014 journal article

Learning from nature – Novel synthetic biology approaches for biomaterial design

Acta Biomaterialia, 10(4), 1761–1769.

By: A. Bryksin, A. Brown, M. Baksh, M. Finn & T. Barker

Source: Crossref
Added: October 23, 2021

2014 journal article

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

Proceedings of the National Academy of Sciences, 111(40), 14430–14435.

By: Y. Qiu, A. Brown, D. Myers, Y. Sakurai, R. Mannino, R. Tran, B. Ahn, E. Hardy ...

Source: Crossref
Added: October 23, 2021

2014 journal article

Ultrasoft microgels displaying emergent platelet-like behaviours

Nature Materials, 13(12), 1108–1114.

By: A. Brown, S. Stabenfeldt, B. Ahn, R. Hannan, K. Dhada, E. Herman, V. Stefanelli, N. Guzzetta ...

Source: Crossref
Added: October 23, 2021

2013 journal article

Colloid-matrix assemblies in regenerative medicine

Current Opinion in Colloid & Interface Science, 18(5), 393–405.

By: K. Clarke, A. Douglas, A. Brown, T. Barker & L. Lyon

Source: Crossref
Added: October 23, 2021

2013 journal article

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

The Journal of Pathology, 229(1), 25–35.

By: A. Brown, V. Fiore, T. Sulchek & T. Barker

Source: Crossref
Added: October 23, 2021

2013 journal article

The Mechanical Properties of Modified Fibrin Fibers: Blocking the B-b Knob-Pocket Interaction

Biophysical Journal, 104(2), 512a–513a.

By: S. Baker, A. Carson Brown, T. Barker & M. Guthold

Source: Crossref
Added: October 23, 2021

2012 journal article

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

Journal of Biomedical Materials Research Part A, 100A(8), 2119–2127.

By: M. Markowski, A. Brown & T. Barker

Source: Crossref
Added: October 23, 2021

2010 journal article

Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals

Lab Chip, 10(5), 571–580.

By: E. Park, A. Brown, M. DiFeo, T. Barker & H. Lu

Source: Crossref
Added: October 23, 2021