Works (72)

Updated: December 6th, 2023 05:01

2023 journal article

Effects of sterilization methods on gelatin methacryloyl hydrogel properties and macrophage gene expression in vitro

BIOMEDICAL MATERIALS, 18(1).

By: F. Zhang*, G. Scull*, J. Gluck*, A. Brown* & M. King*

author keywords: gelatin methacryloyl; hydrogel; sterilization; macrophage phenotype; gene expression
MeSH headings : Hydrogels; Macrophages
Sources: Web Of Science, ORCID
Added: November 22, 2022

2023 journal article

Heparin Affinity-Based IL-4 Delivery to Modulate Macrophage Phenotype and Endothelial Cell Activity In Vitro

ACS APPLIED MATERIALS & INTERFACES, 15(23), 27457–27470.

By: F. Zhang n, J. Gluck n, A. Brown n, D. Zaharoff n & M. King n

co-author countries: United States of America 🇺🇸
author keywords: gelatin methacryloyl; heparin; interleukin4; hydrogel; macrophage; endothelial cell; immunomodulation
MeSH headings : Interleukin-4 / pharmacology; Heparin / pharmacology; Heparin / metabolism; Macrophages / metabolism; Phenotype; Hydrogels / pharmacology; Hydrogels / metabolism
Sources: Web Of Science, ORCID
Added: June 26, 2023

2023 journal article

Influence of Fibrinogen Concentrate on Neonatal Clot Structure When Administered Ex Vivo After Cardiopulmonary Bypass

ANESTHESIA AND ANALGESIA, 137(3), 682–690.

By: N. Moiseiwitsch n, K. Nellenbach n, L. Downey*, D. Boorman*, A. Brown n & N. Guzzetta*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: September 5, 2023

2023 article

Microparticle Hydrogel Material Properties Emerge from Mixing-Induced Homogenization in a Poly(ethylene glycol) and Dextran Aqueous Two-Phase System

Tigner, T. J., Scull, G., Brown, A. C., & Alge, D. L. (2023, October 30). MACROMOLECULES.

By: T. Tigner*, G. Scull n, A. Brown n & D. Alge*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: December 4, 2023

2023 article

Molecular Engineering of Cyclic Azobenzene-Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo-Affinity Chromatography

Prodromou, R., Moore, B. D., Chu, W., Deal, H., San Miguel, A., Brown, A. C., … Menegatti, S. (2023, January 25). ADVANCED FUNCTIONAL MATERIALS, Vol. 1.

By: R. Prodromou n, B. Moore n, W. Chu n, H. Deal n, A. San Miguel n, A. Brown n, M. Daniele n, V. Pozdin*, S. Menegatti n

co-author countries: United States of America 🇺🇸
author keywords: affinity ligands; azobenzene-peptide hybrids; biomolecular recognition; factor VIII; photo-affinity chromatography
Sources: Web Of Science, ORCID
Added: February 20, 2023

2023 review

Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies

[Review of ]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023.

By: A. Sheridan n & A. Brown n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: March 27, 2023

2023 article

Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10.

By: E. Chee n, E. Mihalko*, K. Nellenbach n, J. Sollinger n, K. Huang n, M. Hon n, S. Pandit n, K. Cheng n, A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: fibrin; hemostasis; synthetic platelet; trauma; wound healing
Sources: Web Of Science, ORCID
Added: November 6, 2023

2022 journal article

A Unique Crustacean-Based Chitin Platform to Reduce Self-Aggregation of Polysaccharide Nanofibers

FIBERS, 10(10).

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: polysaccharide nanofibers; crustacean shells; chitin; cellulose; self-aggregation; clotting; foams
Sources: Web Of Science, ORCID
Added: October 19, 2022

2022 review

Biomaterials for Hemostasis

[Review of ]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 24, 111–135.

By: A. Simpson n, A. Shukla* & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: hemostasis; trauma; clotting; sealant; synthetic blood product; layer-by-layer assembly
MeSH headings : Biocompatible Materials; Hemorrhage; Hemostasis; Hemostatics; Humans
Source: Web Of Science
Added: July 11, 2022

2022 article

COVID-19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acid

Moiseiwitsch, N., Zwennes, N., Szlam, F., Sniecinski, R., & Brown, A. (2022, October 5). JOURNAL OF THROMBOSIS AND HAEMOSTASIS.

co-author countries: United States of America 🇺🇸
author keywords: coagulopathy; COVID-19; fibrinogen; sialic acid; thrombosis
MeSH headings : Humans; Fibrinogen / metabolism; Fibrin / chemistry; N-Acetylneuraminic Acid; COVID-19; Polymerization; Neuraminidase; SARS-CoV-2; Fibrinolysis; Thrombosis / metabolism; Hemostatics
Source: Web Of Science
Added: October 17, 2022

2022 article

Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype

Chester, D., Lee, V., Wagner, P., Nordberg, M., Fisher, M. B., & Brown, A. C. (2022, February 1). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.

By: D. Chester n, V. Lee n, P. Wagner n, M. Nordberg n, M. Fisher n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: loss tangent; mechanotransduction; microgel; viscoelasticity
MeSH headings : Biocompatible Materials / chemistry; Hydrogels / chemistry; Hydrogels / pharmacology; Mechanotransduction, Cellular / physiology; Phenotype; Viscosity
Source: Web Of Science
Added: February 7, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n, A. Moatti n, G. Scull n, D. Silkstone n, H. Lutz n, B. López de Juan Abad n, A. George n, E. Belcher n ...

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID, Crossref
Added: October 17, 2022

2022 article

On-demand, remote and lossless manipulation of biofluid droplets

Wang, W., Sun, J., Vallabhuneni, S., Pawlowski, B., Vahabi, H., Nellenbach, K., … Kota, A. K. (2022, September 7). MATERIALS HORIZONS.

By: W. Wang n, J. Sun*, S. Vallabhuneni n, B. Pawlowski*, H. Vahabi*, K. Nellenbach n, A. Brown n, F. Scholle n, J. Zhao*, A. Kota n

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Pandemics / prevention & control; Saliva; Disease Outbreaks; Point-of-Care Systems; Health Personnel
Source: Web Of Science
Added: September 19, 2022

2022 article

Plasma-Induced Diallyldimethylammonium Chloride Antibacterial Hernia Mesh

Wang, Z., Hamedi, H., Zhang, F., El-Shafei, A., Brown, A. C., Gluck, J. M., & King, M. W. (2022, November 29). ACS APPLIED BIO MATERIALS, Vol. 11.

By: Z. Wang n, H. Hamedi n, F. Zhang n, A. El-Shafei n, A. Brown n, J. Gluck n, M. King n

co-author countries: China 🇨🇳 United States of America 🇺🇸
author keywords: hernia mesh; polypropylene; plasma; surface grafting; antibacterial; fibroblast
MeSH headings : Humans; Surgical Mesh / adverse effects; Polypropylenes; Hernia, Ventral / drug therapy; Anti-Bacterial Agents / pharmacology
Sources: Web Of Science, ORCID
Added: November 30, 2022

2022 article

Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages

Nellenbach, K., & Brown, A. C. (2022, April 19). JOURNAL OF THROMBOSIS AND HAEMOSTASIS.

By: K. Nellenbach n & A. Brown n

co-author countries: United States of America 🇺🇸
MeSH headings : Blood Platelets; Humans; Nanoparticles; Platelet Activation
Source: Web Of Science
Added: May 2, 2022

2022 journal article

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

ACTA BIOMATERIALIA, 138, 208–217.

By: C. Moody n, A. Brown n, N. Massaro n, A. Patel n, P. Agarwalla n, A. Simpson n, A. Brown n, H. Zheng n, J. Pierce n, Y. Brudno n

co-author countries: United States of America 🇺🇸
author keywords: Alginate; Click chemistry; Bioconjugation; Ionic cross-linking; Drug capture
Sources: Web Of Science, ORCID
Added: October 31, 2021

2021 journal article

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

BLOOD ADVANCES, 5(23), 5202–5214.

By: K. Nellenbach, A. Kyu, N. Guzzetta & A. Brown

MeSH headings : Adult; Fibrin; Fibrinogen; Fibrinopeptide A; Humans; Infant, Newborn; N-Acetylneuraminic Acid; Polymerization
Source: Web Of Science
Added: January 3, 2022

2021 article

Ex Vivo and In Vivo Evaluation of Fibrinogen Concentrate to Mitigate Post-Surgical Bleeding in Neonates

Moiseiwitsch, N., Nellenbach, K. A., Guzzetta, N. A., Brown, A. C., & Downey, L. (2021, November 23). BLOOD, Vol. 138.

By: N. Moiseiwitsch n, K. Nellenbach n, N. Guzzetta*, A. Brown n & L. Downey*

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: September 6, 2022

2021 journal article

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation

BLOOD ADVANCES, 5(3), 613–627.

By: E. Mihalko n, M. Sandry n, N. Mininni n, K. Nellenbach n, H. Deal n, M. Daniele n, K. Ghadimi*, J. Levy*, A. Brown n

co-author countries: United States of America 🇺🇸
MeSH headings : Disseminated Intravascular Coagulation / drug therapy; Fibrin; Humans; Microcirculation; Nanogels; Thrombosis / drug therapy
Source: Web Of Science
Added: March 22, 2021

2021 article

Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo

Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: E. Mihalko n, K. Nellenbach n, M. Krishnakumar n, N. Moiseiwitsch n, J. Sollinger n, B. Cooley*, A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: disseminated intravascular coagulation; fibrin; nanogels; pNIPAM; targeted delivery; thrombosis; tissue plasminogen activator
Source: Web Of Science
Added: December 20, 2021

2021 journal article

Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing

BULLETIN OF MATHEMATICAL BIOLOGY, 83(5).

By: K. Pearce n, K. Nellenbach n, R. Smith n, A. Brown n & M. Haider n

co-author countries: United States of America 🇺🇸
author keywords: Wound healing; Fibrin polymerization; Kinetics model; Parameter identifiability; Subset selection
MeSH headings : Animals; Cells, Cultured; Fibrin / metabolism; Humans; Kinetics; Models, Biological; Polymerization; Wound Healing
Sources: Web Of Science, ORCID
Added: March 23, 2021

2021 article

Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents

Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21). ADVANCED HEALTHCARE MATERIALS.

By: A. Krissanaprasit n, C. Key n, K. Froehlich n, S. Pontula, E. Mihalko n, D. Dupont*, E. Andersen*, J. Kjems*, A. Brown n, T. LaBean n

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
author keywords: anticoagulants; aptamers; direct thrombin inhibitors; nucleic acids; reversal agents; RNA nanotechnology; RNA origami
MeSH headings : Anticoagulants / pharmacology; Aptamers, Nucleotide / pharmacology; Blood Coagulation; RNA / pharmacology; Thrombin
Source: Web Of Science
Added: June 10, 2021

2021 review

Neonatal coagulopathies: A review of established and emerging treatments

[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE, 246(12), 1447–1457.

By: N. Moiseiwitsch n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: Neonatal; coagulopathy; developmental hemostasis; transfusion
MeSH headings : Animals; Blood Coagulation Disorders / etiology; Blood Coagulation Disorders / therapy; Hemorrhage / etiology; Hemorrhage / therapy; Hemostasis / physiology; Humans; Infant, Newborn; Infant, Newborn, Diseases / etiology; Infant, Newborn, Diseases / therapy
Source: Web Of Science
Added: July 12, 2021

2021 article

Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury

Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: J. Todd*, V. Bharadwaj*, K. Nellenbach n, S. Nandi n, E. Mihalko n, C. Copeland*, A. Brown n, S. Stabenfeldt*

co-author countries: United States of America 🇺🇸
author keywords: blood-brain barrier; coagulopathy; neuroinflammation; permeability; platelet-like particles; traumatic brain injury
MeSH headings : Animals; Blood Platelets / metabolism; Blood-Brain Barrier / metabolism; Brain Injuries, Traumatic / complications; Brain Injuries, Traumatic / drug therapy; Brain Injuries, Traumatic / metabolism; Disease Models, Animal; Mice; Microglia / metabolism
Source: Web Of Science
Added: June 21, 2021

2021 journal article

Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses

COLLOIDS AND SURFACES B-BIOINTERFACES, 204.

By: C. Roosa n, I. Muhamed n, A. Young n, K. Nellenbach n, M. Daniele n, F. Ligler n, A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: Fibrin; Nanoparticles; Wound healing; Regenerative medicine; Fibrin sealant
MeSH headings : Fibrin; Fibrin Tissue Adhesive; Nanoparticles; Polymerization; Wound Healing
Source: Web Of Science
Added: July 19, 2021

2021 journal article

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

ADVANCED THERAPEUTICS, 4(5).

By: S. Nandi n, E. Mihalko n, K. Nellenbach n, M. Castaneda n, J. Schneible n, M. Harp*, H. Deal n, M. Daniele n ...

co-author countries: United States of America 🇺🇸
author keywords: bleeding; Clotting; fibrin; hemostasis; microgel
Sources: Web Of Science, ORCID
Added: April 5, 2021

2020 review

Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria

[Review of ]. BIOMATERIALS SCIENCE, 8(4), 1089–1100.

By: E. Chee n & A. Brown n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Bacterial Infections / drug therapy; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacology; Drug Resistance, Bacterial / drug effects; Humans; Technology, Pharmaceutical
Source: Web Of Science
Added: March 16, 2020

2020 review

Clot Structure and Implications for Bleeding and Thrombosis

[Review of ]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104.

By: E. Mihalko n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: fibrin; clot structure; atomic force microscopy; fibrinolysis; thrombosis
MeSH headings : Fibrin / metabolism; Fibrinolysis; Hemorrhage / metabolism; Hemorrhage / pathology; Humans; Thrombosis / metabolism; Thrombosis / pathology
Source: Web Of Science
Added: February 27, 2020

2020 journal article

Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(3), 299–309.

By: E. Sproul n, S. Nandi n, E. Chee n, S. Sivadanam n, B. Igo n, L. Schreck*, A. Brown n

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
author keywords: Synthetic platelet; Fibrin; Hemostatic material; Trauma; Antimicrobial material; Microgels
Source: Web Of Science
Added: October 12, 2020

2020 journal article

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

CONNECTIVE TISSUE RESEARCH, 61(2), 190–204.

By: P. Huebner n, P. Warren n, D. Chester n, J. Spang*, A. Brown n, M. Fisher n, R. Shirwaiker n

co-author countries: United States of America 🇺🇸
author keywords: 3D printing; atomic force microscopy; elastic modulus; tissue engineering; tissue scaffolds
MeSH headings : Animals; Bioprinting; Collagen / chemistry; Extracellular Matrix / chemistry; Male; Polyesters / chemistry; Printing, Three-Dimensional; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tissue Scaffolds / chemistry
Sources: Web Of Science, ORCID
Added: August 26, 2019

2020 review

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 8(32), 7062–7075.

By: H. Deal n, A. Brown n & M. Daniele n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Culture Techniques; Cell Line; Cell Movement; Cellular Microenvironment; Hemostasis / drug effects; Humans; Hydrogels / chemistry; Hydrogels / metabolism; Macrophages / metabolism; Microfluidics; Models, Animal; Skin; Stereolithography; Wound Healing / drug effects
Source: Web Of Science
Added: September 7, 2020

2020 journal article

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609.

By: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n ...

co-author countries: United States of America 🇺🇸

Contributors: E. Chee n, S. Nandi n, K. Nellenbach n, E. Mihalko n, D. Snider n, L. Morrill n, A. Bond n, E. Sproul n ...

author keywords: antimicrobial; microgels; nanosilver; platelet-mimetic; wound healing
MeSH headings : Acrylic Resins / chemistry; Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Blood Platelets; Clot Retraction; Colony-Forming Units Assay; Fibrin / chemistry; Fibrin / immunology; Gels; Hemorrhage / drug therapy; Hemostasis / drug effects; Liver / injuries; Male; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Microgels; Silver / administration & dosage; Silver / chemistry; Wound Healing
Sources: Web Of Science, ORCID
Added: March 16, 2020

2020 article

Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds

CELLULAR AND MOLECULAR BIOENGINEERING.

By: K. Nellenbach n, S. Nandi n, C. Peeler n, A. Kyu n & A. Brown n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: June 15, 2020

2020 journal article

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.

co-author countries: United States of America 🇺🇸
author keywords: Fibrin; Biomimetic; Platelet; Hemophilia; Biomaterials
MeSH headings : Blood Coagulation; Blood Platelets; Fibrin; Plasma; Wound Healing
Source: Web Of Science
Added: August 24, 2020

2020 journal article

Ultrasonic Microplotting of Microgel Bioinks

ACS APPLIED MATERIALS & INTERFACES, 12(42), 47309–47319.

co-author countries: United States of America 🇺🇸
author keywords: microgel; microplotting; patterned films; layer-by-layer fabrication; bioink
MeSH headings : Ink; Microgels / analysis; Molecular Structure; Particle Size; Surface Properties; Tissue Scaffolds / chemistry; Ultrasonic Waves
Source: Web Of Science
Added: December 21, 2020

2020 journal article

Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 3026–3036.

By: S. Nandi n, K. Mohanty n, K. Nellenbach n, M. Erb n, M. Muller n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: biomimetic; fibrin; wound healing clot retraction; artificial platelet
MeSH headings : Blood Coagulation; Blood Platelets; Clot Retraction; Fibrin; Wound Healing
Source: Web Of Science
Added: June 8, 2020

2019 review

Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen

[Review of ]. BIOCONJUGATE CHEMISTRY, 30(7), 1951–1956.

By: A. Brown n, E. Lavik* & S. Stabenfeldt*

co-author countries: United States of America 🇺🇸
MeSH headings : Biomimetics; Blood-Brain Barrier; Brain Injuries, Traumatic / therapy; Fibrinogen / metabolism; Humans
Source: Web Of Science
Added: August 12, 2019

2019 journal article

Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate

ACS APPLIED MATERIALS & INTERFACES, 11(4), 3771–3780.

By: I. Muhamed n, E. Sproul n, F. Ligler n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: fibrin nanoparticles; tissue regeneration; cell migration; microfluidics; wound healing; biomaterials; cell migration; in vitro 3D wound model and in vivo dermal wound model
MeSH headings : Animals; Biocompatible Materials / chemistry; Cell Movement / drug effects; Fibrin / chemistry; Fibroblast Growth Factor 7 / chemistry; Fibroblast Growth Factor 7 / therapeutic use; Mice; Microfluidics; Nanoparticles / chemistry; Wound Healing / drug effects
Source: Web Of Science
Added: February 18, 2019

2019 article

Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation

Brown, A. C., & Levy, J. H. (2019, September). ANESTHESIOLOGY, Vol. 131, pp. 459–461.

By: A. Brown n & J. Levy n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Blood Coagulation Factors; Disseminated Intravascular Coagulation; Hemostasis; Hemostatics; Swine
Source: Web Of Science
Added: September 23, 2019

2019 journal article

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

BIOMATERIALS SCIENCE, 7(2), 669–682.

By: S. Nandi n, E. Sproul n, K. Nellenbach n, M. Erb n, L. Gaffney n, D. Freytes n, A. Brown n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Biomimetic Materials / chemistry; Blood Platelets / metabolism; Blood Platelets / physiology; Fibrin / chemistry; Fibrin / pharmacology; Humans; Mechanical Phenomena; Mice; Platelet Activation / drug effects; Skin / drug effects; Skin / injuries; Wound Healing / drug effects
Source: Web Of Science
Added: February 18, 2019

2019 article

Wound Healing and the Host Response in Regenerative Engineering

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.

By: D. Chester*, E. Marrow, M. Daniele* & A. Brown*

Source: Web Of Science
Added: April 14, 2020

2018 journal article

Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes

ADVANCED BIOSYSTEMS, 2(10).

By: E. Sproul n, S. Nandi n, C. Roosa n, L. Schreck* & A. Brown n

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
author keywords: biomimetic; fibrin; microgel; synthetic platelet; wound healing
Source: Web Of Science
Added: October 29, 2018

2018 journal article

Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels

COLLOIDS AND SURFACES B-BIOINTERFACES, 166, 89–97.

By: N. Welsch*, A. Brown n, T. Barker* & L. Lyon*

co-author countries: United States of America 🇺🇸
author keywords: Oligoethylene glycol-based microgels; Platelet-like particles; Fibrin clot; Fibrin-targeting antibodies; Elastic modulus; Permeability
MeSH headings : Elastic Modulus; Fibrin / chemistry; Polyethylene Glycols / chemistry; Polymers / chemistry
Source: Web Of Science
Added: August 6, 2018

2018 article

Fibrin biomaterials for tissue regeneration and repair

PEPTIDES AND PROTEINS AS BIOMATERIALS FOR TISSUE REGENERATION AND REPAIR, pp. 151–173.

By: E. Sproul n, S. Nandi n & A. Brown n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo

LAB ON A CHIP, 18(19), 2985–2993.

By: E. Hardy*, Y. Wang*, S. Iyer*, R. Mannino*, Y. Sakurai*, T. Barker*, T. Chi*, Y. Youn* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Blood Coagulation; Electricity; Hemostasis; Humans; Microtechnology / instrumentation
Source: Web Of Science
Added: November 19, 2018

2018 review

Material Strategies for Modulating Epithelial to Mesenchymal Transitions

[Review of ]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1149–1161.

By: E. Mihalko n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: epithelial to mesenchymal transition; EMT; mechanotransduction; fibrosis; development; transforming growth factor beta; EndoMT
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Study of Poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation

LANGMUIR, 34(4), 1457–1465.

By: A. Joshi*, S. Nandi n, D. Chester n, A. Brown n & M. Muller n

co-author countries: United States of America 🇺🇸
MeSH headings : Acrylates / chemistry; Acrylic Resins / chemistry; Drug Delivery Systems; Gels / chemistry; Polymers / chemistry
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

By: E. Mihalko n, K. Huang n, E. Sproul n, K. Cheng n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: microgels; myocardial infarction; fibrin; fibrinolytic; fibrosis; ischemia reperfusion; drug delivery
MeSH headings : Acrylic Resins / chemical synthesis; Acrylic Resins / chemistry; Acrylic Resins / therapeutic use; Animals; Fibrosis / complications; Fibrosis / drug therapy; Fibrosis / metabolism; Ischemia / complications; Ischemia / drug therapy; Ischemia / metabolism; Myocardial Infarction / drug therapy; Myocardial Infarction / metabolism; Myocardial Infarction / pathology; Nanogels; Polyethylene Glycols / chemical synthesis; Polyethylene Glycols / chemistry; Polyethylene Glycols / therapeutic use; Polyethyleneimine / chemical synthesis; Polyethyleneimine / chemistry; Polyethyleneimine / therapeutic use; Rats
Sources: Crossref, ORCID
Added: February 21, 2020

2018 journal article

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26.

By: J. Tang n, T. Su n, K. Huang, P. Dinh n, Z. Wang*, A. Vandergriff n, M. Hensley n, J. Cores n ...

co-author countries: China 🇨🇳 Japan 🇯🇵 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

BIOMATERIALS, 185, 371–382.

By: D. Chester n, R. Kathard n, J. Nortey n, K. Nellenbach n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: Microgels; Colloidal thin film; Fibroblasts; Mechanotransduction; Self-healing
MeSH headings : Biocompatible Materials / chemistry; Cell Adhesion; Cell Differentiation; Cell Line; Cell Movement; Elastic Modulus; Fibroblasts / cytology; Fibrosis / etiology; Gels / chemistry; Humans; Mechanotransduction, Cellular; Viscosity
Source: Web Of Science
Added: November 12, 2018

2017 journal article

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (126).

By: S. Nandi n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: Bioengineering; Issue 126; cell migration; three dimensional; fibrin; wound healing; extracellular matrix; integrins; in vitro wound healing assay
MeSH headings : Bioengineering / methods; Cell Movement / physiology; Humans; Wound Healing / physiology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis

ACS NANO, 11(7), 7110–7117.

By: L. Cao*, J. Nicosia*, J. Larouche*, Y. Zhang*, H. Bachman*, A. Brown n, L. Holmgren*, T. Barker*

co-author countries: Sweden 🇸🇪 United States of America 🇺🇸
author keywords: mechano-biology; antibody phage display; integrins; fibronectin; fibrosis; angiogenesis
MeSH headings : Animals; Biomechanical Phenomena; Cell Adhesion; Extracellular Matrix / metabolism; Fibronectins / analysis; Fibronectins / metabolism; Fibrosis; Integrins / analysis; Integrins / metabolism; Lung / metabolism; Lung / pathology; Mice; Neovascularization, Physiologic; Protein Binding
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Peptide Mimetic Drugs for Modulating Thrombosis and Hemostasis

DRUG DEVELOPMENT RESEARCH, 78(6), 236–244.

By: K. Nellenbach n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: thrombosis; hemostasis; peptide-mimetic; fibrinogen; thrombin; platelet
MeSH headings : Animals; Blood Coagulation; Fibrinolytic Agents / pharmacology; Hemostasis / drug effects; Humans; Peptidomimetics / pharmacology; Risk Factors; Thrombosis / drug therapy
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Single-platelet nanomechanics measured by high-throughput cytometry

NATURE MATERIALS, 16(2), 230–235.

By: D. Myers*, Y. Qiu*, M. Fay*, M. Tennenbaum*, D. Chester n, J. Cuadrado*, Y. Sakurai*, J. Baek* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Blood Coagulation / physiology; Blood Flow Velocity / physiology; Blood Platelets / physiology; Cells, Cultured; Elastic Modulus / physiology; Flow Cytometry / methods; Hardness / physiology; Humans; Mechanotransduction, Cellular / physiology; Nanoparticles / chemistry; Platelet Activation / physiology; Platelet Adhesiveness / physiology
Source: Web Of Science
Added: August 6, 2018

2017 review

The role of biophysical properties of provisional matrix proteins in wound repair

[Review of ]. MATRIX BIOLOGY, 60-61, 124–140.

By: D. Chester n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: Wound healing; Extracellular matrix; Biophysics; Fibrin; Fibrinogen; Fibronectin; Collagen; Transforming growth factor beta; Platelets
MeSH headings : Animals; Blood Platelets / cytology; Blood Platelets / drug effects; Blood Platelets / metabolism; Cell Communication / drug effects; Cell Proliferation / drug effects; Collagen / chemistry; Collagen / genetics; Collagen / metabolism; Dermis / injuries; Dermis / metabolism; Dermis / pathology; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Fibronectins / chemistry; Fibronectins / genetics; Fibronectins / metabolism; Gene Expression; Humans; Integrins / chemistry; Integrins / genetics; Integrins / metabolism; Intercellular Signaling Peptides and Proteins / genetics; Intercellular Signaling Peptides and Proteins / metabolism; Intercellular Signaling Peptides and Proteins / pharmacology; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Protein Subunits / chemistry; Protein Subunits / genetics; Protein Subunits / metabolism; Wound Healing / drug effects; Wound Healing / physiology
Source: Web Of Science
Added: August 6, 2018

2016 article

Fibrin Network Changes in Neonates after Cardiopulmonary Bypass

Brown, A. C., Hannan, R. H., Timmins, L. H., Fernandez, J. D., Barker, T. H., & Guzzetta, N. A. (2016, May). ANESTHESIOLOGY, Vol. 124, pp. 1021–1031.

By: A. Brown n, R. Hannan n, L. Timmins n, J. Fernandez n, T. Barker n & N. Guzzetta n

co-author countries: United States of America 🇺🇸
MeSH headings : Adult; Blood Coagulation; Blood Loss, Surgical; Blood Transfusion; Cardiopulmonary Bypass / adverse effects; Factor XIII / analysis; Female; Fibrin; Fibrinogen / metabolism; Humans; Infant; Infant, Newborn; Male; Microscopy, Confocal; Prothrombin / analysis
Source: Web Of Science
Added: August 6, 2018

2016 review

Platelet-mimetic strategies for modulating the wound environment and inflammatory responses

[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(10), 1138–1148.

By: S. Nandi n & A. Brown n

co-author countries: United States of America 🇺🇸
author keywords: Platelets; hemostasis; artificial platelets; platelet-mimetic; nanoparticles; bionanoscience
MeSH headings : Artificial Cells; Blood Platelets / physiology; Inflammation / pathology; Inflammation / physiopathology; Models, Theoretical; Wounds and Injuries / pathology; Wounds and Injuries / physiopathology
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells

BIOCONJUGATE CHEMISTRY, 26(12), 2336–2349.

By: L. Karumbaiah*, S. Enam, A. Brown n, T. Saxena, M. Betancur*, T. Barker, R. Bellamkonda

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Brain-Derived Neurotrophic Factor / administration & dosage; Cell Proliferation; Cells, Cultured; Chondroitin Sulfates / chemistry; Fibroblast Growth Factor 2 / administration & dosage; Hydrogels / chemistry; Neural Stem Cells / cytology; Rats; Tissue Scaffolds / chemistry
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Integrin alpha 3 beta 1 binding to fibronectin is dependent on the ninth type III repeat

Journal of Biological Chemistry, 290(42), 25534–25547.

By: A. Brown n, M. Dysart*, K. Clarke*, S. Stabenfeldt* & T. Barker*

co-author countries: United States of America 🇺🇸
MeSH headings : Amino Acid Sequence; Cell Adhesion; Cell Line; Fibronectins / chemistry; Fibronectins / genetics; Fibronectins / metabolism; Humans; Integrin alpha3beta1 / metabolism; Molecular Sequence Data; Mutation; Protein Binding
Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties

Biomaterials, 49, 27–36.

co-author countries: United States of America 🇺🇸
author keywords: Fibrin; Fibrinogen; Mechanical properties; Biocompatibility
MeSH headings : Biocompatible Materials / chemistry; Blood Coagulation; Fibrin / chemistry; Humans; Kinetics; Materials Testing; Microscopy, Confocal; Peptides / chemistry; Polyethylene Glycols / chemistry; Polymerization; Rheology; Stress, Mechanical; Surface Plasmon Resonance
Source: Crossref
Added: August 16, 2021

2015 journal article

Ultrasoft, highly deformable microgels

Soft Matter, 11(10), 2018–2028.

By: H. Bachman*, A. Brown*, K. Clarke*, K. Dhada*, A. Douglas*, C. Hansen*, E. Herman*, J. Hyatt* ...

co-author countries: Germany 🇩🇪 United States of America 🇺🇸
MeSH headings : Acrylamides; Acrylates / chemistry; Acrylic Resins / chemistry; Ammonium Sulfate / chemistry; Cross-Linking Reagents / chemistry; Hydrogels / chemistry; Isocyanates / chemistry; Polyethylene Glycols / chemistry; Rheology; Silanes / chemistry; Sodium Dodecyl Sulfate / chemistry
Source: Crossref
Added: August 16, 2021

2014 journal article

Direct observation of ligand-induced receptor dimerization with a bioresponsive hydrogel

RSC Advances, 4(110), 65173–65175.

By: J. Kim, Y. Park*, A. Brown* & L. Lyon*

co-author countries: Korea (Republic of) 🇰🇷 United States of America 🇺🇸
Source: Crossref
Added: October 23, 2021

2014 journal article

Fibrin Fibers: Blocking the B:B Knob-Pocket Interaction

Biophysical Journal, 106(2), 614a.

By: S. Baker*, A. Carson-Brown*, M. Guthold* & T. Barker*

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: October 23, 2021

2014 journal article

Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level

Acta Biomaterialia, 10(4), 1502–1514.

By: A. Brown* & T. Barker*

co-author countries: United States of America 🇺🇸
author keywords: Fibrin; Biomaterial design; Fibrin glue; Wound repair; Tissue engineering
MeSH headings : Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Fibrin / chemistry; Fibrin / pharmacology; Humans; Polymerization / drug effects; Proteolysis / drug effects; Tissue Engineering / methods
Source: Crossref
Added: August 16, 2021

2014 journal article

Learning from nature – Novel synthetic biology approaches for biomaterial design

Acta Biomaterialia, 10(4), 1761–1769.

By: A. Bryksin*, A. Brown*, M. Baksh*, M. Finn* & T. Barker*

co-author countries: United States of America 🇺🇸
author keywords: Synthetic biology; Biomaterials; Directed evolution; Tissue engineering; Virus particles
MeSH headings : Biocompatible Materials / chemistry; Polymers / chemistry; Synthetic Biology / methods; Tissue Scaffolds / chemistry; Virion / chemistry
Source: Crossref
Added: October 23, 2021

2014 journal article

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

Proceedings of the National Academy of Sciences, 111(40), 14430–14435.

By: Y. Qiu*, A. Brown*, D. Myers*, Y. Sakurai*, R. Mannino*, R. Tran*, B. Ahn*, E. Hardy* ...

co-author countries: United States of America 🇺🇸
author keywords: mechanotransduction; cell mechanics; platelet cytoskeleton; biomaterials
MeSH headings : Acrylic Resins / metabolism; Blood Coagulation / physiology; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Movement / physiology; Cellular Microenvironment / physiology; Fibrin / metabolism; Fibrinogen / metabolism; Humans; Immobilized Proteins / metabolism; Mechanotransduction, Cellular / physiology; Microscopy, Confocal; P-Selectin / metabolism; Phosphatidylserines / metabolism; Platelet Activation / physiology; Platelet Adhesiveness / physiology; Platelet Aggregation / physiology; Platelet Glycoprotein GPIIb-IIIa Complex / metabolism; Stress, Mechanical; Thrombosis / physiopathology; rac1 GTP-Binding Protein / metabolism
Source: Crossref
Added: October 23, 2021

2014 journal article

Ultrasoft microgels displaying emergent platelet-like behaviours

Nature Materials, 13(12), 1108–1114.

By: A. Brown*, S. Stabenfeldt*, B. Ahn*, R. Hannan*, K. Dhada*, E. Herman*, V. Stefanelli*, N. Guzzetta* ...

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: October 23, 2021

2013 journal article

Colloid-matrix assemblies in regenerative medicine

Current Opinion in Colloid & Interface Science, 18(5), 393–405.

By: K. Clarke, A. Douglas, A. Brown*, T. Barker & L. Lyon

author keywords: Extracellular matrix; Fibrin; Colloids; Composites; Tissue engineering; Regenerative medicine
Source: Crossref
Added: October 23, 2021

2013 journal article

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

The Journal of Pathology, 229(1), 25–35.

By: A. Brown*, V. Fiore*, T. Sulchek* & T. Barker*

co-author countries: United States of America 🇺🇸
author keywords: idiopathic pulmonary fibrosis; epithelial-to-mesenchymal transition; fibrosis; stiffness; cell contractility; alveolar epithelial cell
MeSH headings : Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Biomechanical Phenomena; Bleomycin; Cells, Cultured; Cellular Microenvironment; Coculture Techniques; Disease Models, Animal; Elastic Modulus; Epithelial-Mesenchymal Transition; Fibronectins / metabolism; Integrins / metabolism; Laminin / metabolism; Lung / metabolism; Lung / pathology; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Microscopy, Atomic Force; Mink; Nanotechnology; Phenotype; Pulmonary Fibrosis / metabolism; Pulmonary Fibrosis / pathology; Rats; Rats, Sprague-Dawley; Thrombin / metabolism; Time Factors; Transforming Growth Factor beta / metabolism
Source: Crossref
Added: October 23, 2021

2013 journal article

The Mechanical Properties of Modified Fibrin Fibers: Blocking the B-b Knob-Pocket Interaction

Biophysical Journal, 104(2), 512a–513a.

By: S. Baker*, A. Carson Brown, T. Barker* & M. Guthold*

co-author countries: United States of America 🇺🇸
Source: Crossref
Added: October 23, 2021

2012 journal article

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

Journal of Biomedical Materials Research Part A, 100A(8), 2119–2127.

By: M. Markowski*, A. Brown* & T. Barker*

co-author countries: United States of America 🇺🇸
author keywords: epithelial to mesenchymal transition; fibronectin mutant; substrate stiffness; cell contractility; alveolar epithelial cell
MeSH headings : Animals; Biomarkers / metabolism; Cell Adhesion / drug effects; Cell Line; Cellular Microenvironment / drug effects; Cues; Epithelial Cells / cytology; Epithelial-Mesenchymal Transition / drug effects; Fibronectins / chemistry; Fibronectins / pharmacology; Mink; Phenotype; Protein Stability / drug effects; Pulmonary Alveoli / cytology; Repetitive Sequences, Amino Acid; Transforming Growth Factor beta / pharmacology
Source: Crossref
Added: October 23, 2021

2010 journal article

Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals

Lab Chip, 10(5), 571–580.

By: E. Park*, A. Brown*, M. DiFeo*, T. Barker* & H. Lu*

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Culture Techniques / instrumentation; Cells, Cultured; Epithelial Cells / drug effects; Epithelial Cells / physiology; Equipment Design; Equipment Failure Analysis; Extracellular Matrix Proteins / metabolism; Flow Injection Analysis / instrumentation; Humans; Microfluidic Analytical Techniques / instrumentation; Reproducibility of Results; Sensitivity and Specificity; Solubility; Specimen Handling / instrumentation; Transforming Growth Factor beta1 / pharmacology
Source: Crossref
Added: October 23, 2021

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