Ashley Carson Brown

Biomaterials for Hemostasis

[Review of ]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING.

Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype

Chester, D., Lee, V., Wagner, P., Nordberg, M., Fisher, M. B., & Brown, A. C. (2022, February 1). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A.

On-demand, remote and lossless manipulation of biofluid droplets

Wang, W., Sun, J., Vallabhuneni, S., Pawlowski, B., Vahabi, H., Nellenbach, K., … Kota, A. K. (2022, September 7). MATERIALS HORIZONS.

Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages

Nellenbach, K., & Brown, A. C. (2022, April 19). JOURNAL OF THROMBOSIS AND HAEMOSTASIS.

Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture

ACTA BIOMATERIALIA.

Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics

BLOOD ADVANCES.

Ex Vivo and In Vivo Evaluation of Fibrinogen Concentrate to Mitigate Post-Surgical Bleeding in Neonates

Moiseiwitsch, N., Nellenbach, K. A., Guzzetta, N. A., Brown, A. C., & Downey, L. (2021, November 23). BLOOD.

Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation

BLOOD ADVANCES, 5(3), 613–627.

Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo

Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). BIOENGINEERING & TRANSLATIONAL MEDICINE.

Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing

BULLETIN OF MATHEMATICAL BIOLOGY, 83(5).

Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents

Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21). ADVANCED HEALTHCARE MATERIALS.

Neonatal coagulopathies: A review of established and emerging treatments

[Review of ]. EXPERIMENTAL BIOLOGY AND MEDICINE.

Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury

Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses

COLLOIDS AND SURFACES B-BIOINTERFACES.

Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses

ADVANCED THERAPEUTICS.

Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria

[Review of ]. BIOMATERIALS SCIENCE, 8(4), 1089–1100.

Clot Structure and Implications for Bleeding and Thrombosis

[Review of ]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104.

Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites

REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(3), 299–309.

Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies

[Review of ]. JOURNAL OF MATERIALS CHEMISTRY B, 8(32), 7062–7075.

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds

CELLULAR AND MOLECULAR BIOENGINEERING.

Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418.

Ultrasonic Microplotting of Microgel Bioinks

ACS APPLIED MATERIALS & INTERFACES, 12(42), 47309–47319.

Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair

ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 3026–3036.

Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen

[Review of ]. BIOCONJUGATE CHEMISTRY, 30(7), 1951–1956.

Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate

ACS APPLIED MATERIALS & INTERFACES, 11(4), 3771–3780.

Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation

Brown, A. C., & Levy, J. H. (2019, September). ANESTHESIOLOGY, Vol. 131, pp. 459–461.

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

CONNECTIVE TISSUE RESEARCH.

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

BIOMATERIALS SCIENCE, 7(2), 669–682.

Wound Healing and the Host Response in Regenerative Engineering

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718.

Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes

ADVANCED BIOSYSTEMS, 2(10).

Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels

Colloids and Surfaces. B, Biointerfaces, 166, 89–97.

Fibrin biomaterials for tissue regeneration and repair

Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair, 151–173.

Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo

LAB ON A CHIP, 18(19), 2985–2993.

Material strategies for modulating epithelial to mesenchymal transitions

[Review of ]. ACS Biomaterials-Science & Engineering, 4(4), 1149–1161.

Study of poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) microgel particle induced deformations of tissue-mimicking phantom by ultrasound stimulation

Langmuir, 34(4), 1457–1465.

Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic

ACS Nano, 12(8), 7826–7837.

Targeted repair of heart injury by stem cells fused with platelet nanovesicles

Nature Biomedical Engineering, 2(1), 17–26.

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

BIOMATERIALS, 185, 371–382.

Characterizing cell migration within three-dimensional in vitro wound environments

Jove-Journal of Visualized Experiments, (126).

Detection of an integrin-binding mechanoswitch within fibronectin during tissue formation and fibrosis

ACS Nano, 11(7), 7110–7117.

Peptide mimetic drugs for modulating thrombosis and hemostasis

Drug Development Research, 78(6), 236–244.

Single-platelet nanomechanics measured by high-throughput cytometry

Nature Materials, 16(2), 230–235.

The role of biophysical properties of provisional matrix proteins in wound repair

[Review of ]. Matrix biology, 60-61, 124–140.

Fibrin network changes in neonates after cardiopulmonary bypass

Anesthesiology, 124(5), 1021–1031.

Platelet-mimetic strategies for modulating the wound environment and inflammatory responses

[Review of ]. Experimental Biology and Medicine, 241(10), 1138–1148.

Chondroitin sulfate glycosaminoglycan hydrogels create endogenous niches for neural stem cells

Bioconjugate Chemistry, 26(12), 2336–2349.

Integrin alpha 3 beta 1 binding to fibronectin is dependent on the ninth type III repeat

Journal of Biological Chemistry, 290(42), 25534–25547.

Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties

Biomaterials, 49, 27–36.

Ultrasoft, highly deformable microgels

Soft Matter, 11(10), 2018–2028.

Direct observation of ligand-induced receptor dimerization with a bioresponsive hydrogel

RSC Advances, 4(110), 65173–65175.

Fibrin Fibers: Blocking the B:B Knob-Pocket Interaction

Biophysical Journal, 106(2), 614a.

Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level

Acta Biomaterialia, 10(4), 1502–1514.

Learning from nature – Novel synthetic biology approaches for biomaterial design

Acta Biomaterialia, 10(4), 1761–1769.

Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation

Proceedings of the National Academy of Sciences, 111(40), 14430–14435.

Ultrasoft microgels displaying emergent platelet-like behaviours

Nature Materials, 13(12), 1108–1114.

Colloid-matrix assemblies in regenerative medicine

Current Opinion in Colloid & Interface Science, 18(5), 393–405.

Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions

The Journal of Pathology, 229(1), 25–35.

The Mechanical Properties of Modified Fibrin Fibers: Blocking the B-b Knob-Pocket Interaction

Biophysical Journal, 104(2), 512a–513a.

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

Journal of Biomedical Materials Research Part A, 100A(8), 2119–2127.

Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals

Lab Chip, 10(5), 571–580.