Ashley Brown

Simpson, A., Krissanaprasit, A., Chester, D., Koehler, C., Labean, T. H., & Brown, A. C. (2024, March 9). Utilizing multiscale engineered biomaterials to examine TGF-β-mediated myofibroblastic differentiation. WOUND REPAIR AND REGENERATION. https://doi.org/10.1111/wrr.13168

Zhang, F., Scull, G., Gluck, J. M., Brown, A. C., & King, M. W. (2023). Effects of sterilization methods on gelatin methacryloyl hydrogel properties and macrophage gene expression in vitro. BIOMEDICAL MATERIALS, 18(1). https://doi.org/10.1088/1748-605X/aca4b2

Zhang, F., Gluck, J. M., Brown, A. C., Zaharoff, D. A., & King, M. W. (2023). Heparin Affinity-Based IL-4 Delivery to Modulate Macrophage Phenotype and Endothelial Cell Activity In Vitro. ACS APPLIED MATERIALS & INTERFACES, 15(23), 27457–27470. https://doi.org/10.1021/acsami.3c00489

Moiseiwitsch, N., Nellenbach, K. A., Downey, L. A., Boorman, D., Brown, A. C., & Guzzetta, N. A. (2023). Influence of Fibrinogen Concentrate on Neonatal Clot Structure When Administered Ex Vivo After Cardiopulmonary Bypass. ANESTHESIA AND ANALGESIA, 137(3), 682–690. https://doi.org/10.1213/ANE.0000000000006357

Tigner, T. J., Scull, G., Brown, A. C., & Alge, D. L. (2023, October 30). Microparticle Hydrogel Material Properties Emerge from Mixing-Induced Homogenization in a Poly(ethylene glycol) and Dextran Aqueous Two-Phase System. MACROMOLECULES. https://doi.org/10.1021/acs.macromol.3c00557

Prodromou, R., Moore, B. D., Chu, W., Deal, H., San Miguel, A., Brown, A. C., … Menegatti, S. (2023, January 25). Molecular Engineering of Cyclic Azobenzene-Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo-Affinity Chromatography. ADVANCED FUNCTIONAL MATERIALS, Vol. 1. https://doi.org/10.1002/adfm.202213881

Sheridan, A., & Brown, A. C. (2023). [Review of Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies]. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2023. https://doi.org/10.1155/2023/6117810

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10. https://doi.org/10.1002/jbm.a.37625

Londono-Zuluaga, C., Jameel, H., Gonzalez, R., Nellenbach, K., Brown, A., Yang, G., & Lucia, L. (2022). A Unique Crustacean-Based Chitin Platform to Reduce Self-Aggregation of Polysaccharide Nanofibers. FIBERS, 10(10). https://doi.org/10.3390/fib10100087

Simpson, A., Shukla, A., & Brown, A. C. (2022). [Review of Biomaterials for Hemostasis]. ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 24, 111–135. https://doi.org/10.1146/annurev-bioeng-012521-101942

Moiseiwitsch, N., Zwennes, N., Szlam, F., Sniecinski, R., & Brown, A. (2022, October 5). COVID-19 patient fibrinogen produces dense clots with altered polymerization kinetics, partially explained by increased sialic acid. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. https://doi.org/10.1111/jth.15882

Chester, D., Lee, V., Wagner, P., Nordberg, M., Fisher, M. B., & Brown, A. C. (2022, February 1). Elucidating the combinatorial effect of substrate stiffness and surface viscoelasticity on cellular phenotype. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A. https://doi.org/10.1002/jbm.a.37367

Popowski, K. D., Moatti, A., Scull, G., Silkstone, D., Lutz, H., López de Juan Abad, B., … Cheng, K. (2022). Inhalable dry powder mRNA vaccines based on extracellular vesicles. Matter, 5(9), 2960–2974. https://doi.org/10.1016/j.matt.2022.06.012

Wang, W., Sun, J., Vallabhuneni, S., Pawlowski, B., Vahabi, H., Nellenbach, K., … Kota, A. K. (2022, September 7). On-demand, remote and lossless manipulation of biofluid droplets. MATERIALS HORIZONS. https://doi.org/10.1039/d2mh00695b

Wang, Z., Hamedi, H., Zhang, F., El-Shafei, A., Brown, A. C., Gluck, J. M., & King, M. W. (2022, November 29). Plasma-Induced Diallyldimethylammonium Chloride Antibacterial Hernia Mesh. ACS APPLIED BIO MATERIALS, Vol. 11. https://doi.org/10.1021/acsabm.2c00695

Nellenbach, K., & Brown, A. C. (2022, April 19). Platelet-mimicking procoagulant nanoparticles: Potential strategies for mitigating blood shortages. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. https://doi.org/10.1111/jth.15720

Moody, C. T., Brown, A. E., Massaro, N. P., Patel, A. S., Agarwalla, P. A., Simpson, A. M., … Brudno, Y. (2022). Restoring Carboxylates on Highly Modified Alginates Improves Gelation, Tissue Retention and Systemic Capture. ACTA BIOMATERIALIA, 138, 208–217. https://doi.org/10.1016/j.actbio.2021.10.046

Nellenbach, K., Kyu, A., Guzzetta, N., & Brown, A. C. (2021). Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics. BLOOD ADVANCES, 5(23), 5202–5214. https://doi.org/10.1182/bloodadvances.2021004417.

Moiseiwitsch, N., Nellenbach, K. A., Guzzetta, N. A., Brown, A. C., & Downey, L. (2021, November 23). Ex Vivo and In Vivo Evaluation of Fibrinogen Concentrate to Mitigate Post-Surgical Bleeding in Neonates. BLOOD, Vol. 138. https://doi.org/10.1182/blood-2021-153823

Mihalko, E. P., Sandry, M., Mininni, N., Nellenbach, K., Deal, H., Daniele, M., … Brown, A. C. (2021). Fibrin-modulating nanogels for treatment of disseminated intravascular coagulation. BLOOD ADVANCES, 5(3), 613–627. https://doi.org/10.1182/bloodadvances.2020003046

Mihalko, E. P., Nellenbach, K., Krishnakumar, M., Moiseiwitsch, N., Sollinger, J., Cooley, B. C., & Brown, A. C. (2021, December 11). Fibrin-specific poly(N-isopropylacrylamide) nanogels for targeted delivery of tissue-type plasminogen activator to treat thrombotic complications are well tolerated in vivo. BIOENGINEERING & TRANSLATIONAL MEDICINE. https://doi.org/10.1002/btm2.10277

Pearce, K. J., Nellenbach, K., Smith, R. C., Brown, A. C., & Haider, M. A. (2021). Modeling and Parameter Subset Selection for Fibrin Polymerization Kinetics with Applications to Wound Healing. BULLETIN OF MATHEMATICAL BIOLOGY, 83(5). https://doi.org/10.1007/s11538-021-00876-6

Krissanaprasit, A., Key, C. M., Froehlich, K., Pontula, S., Mihalko, E., Dupont, D. M., … LaBean, T. H. (2021, April 21). Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents. ADVANCED HEALTHCARE MATERIALS. https://doi.org/10.1002/adhm.202001826

Moiseiwitsch, N., & Brown, A. C. (2021). [Review of Neonatal coagulopathies: A review of established and emerging treatments]. EXPERIMENTAL BIOLOGY AND MEDICINE, 246(12), 1447–1457. https://doi.org/10.1177/15353702211006046

Todd, J., Bharadwaj, V. N., Nellenbach, K., Nandi, S., Mihalko, E., Copeland, C., … Stabenfeldt, S. E. (2021, June 11). Platelet-like particles reduce coagulopathy-related and neuroinflammatory pathologies post-experimental traumatic brain injury. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. https://doi.org/10.1002/jbm.b.34888

Roosa, C. A., Muhamed, I., Young, A. T., Nellenbach, K., Daniele, M. A., Ligler, F. S., & Brown, A. C. (2021). Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses. COLLOIDS AND SURFACES B-BIOINTERFACES, 204. https://doi.org/10.1016/j.colsurfb.2021.111805

Nandi, S., Mihalko, E., Nellenbach, K., Castaneda, M., Schneible, J., Harp, M., … Brown, A. C. (2021). Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses. ADVANCED THERAPEUTICS, 4(5). https://doi.org/10.1002/adtp.202100010

Chee, E., & Brown, A. C. (2020). [Review of Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria]. BIOMATERIALS SCIENCE, 8(4), 1089–1100. https://doi.org/10.1039/c9bm01393h

Mihalko, E., & Brown, A. C. (2020). [Review of Clot Structure and Implications for Bleeding and Thrombosis]. SEMINARS IN THROMBOSIS AND HEMOSTASIS, 46(1), 96–104. https://doi.org/10.1055/s-0039-1696944

Sproul, E. P., Nandi, S., Chee, E., Sivadanam, S., Igo, B. J., Schreck, L., & Brown, A. C. (2020). Development of Biomimetic Antimicrobial Platelet-Like Particles Comprised of Microgel Nanogold Composites. REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE, 6(3), 299–309. https://doi.org/10.1007/s40883-019-00121-6

Huebner, P., Warren, P. B., Chester, D., Spang, J. T., Brown, A. C., Fisher, M. B., & Shirwaiker, R. A. (2020). Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment. CONNECTIVE TISSUE RESEARCH, 61(2), 190–204. https://doi.org/10.1080/03008207.2019.1624733

Deal, H. E., Brown, A. C., & Daniele, M. A. (2020). [Review of Microphysiological systems for the modeling of wound healing and evaluation of pro-healing therapies]. JOURNAL OF MATERIALS CHEMISTRY B, 8(32), 7062–7075. https://doi.org/10.1039/d0tb00544d

Chee, E., Nandi, S., Nellenbach, K., Mihalko, E., Snider, D. B., Morrill, L., … Brown, A. C. (2020). Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(6), 2599–2609. https://doi.org/10.1002/jbm.b.34592

Nellenbach, K., Nandi, S., Peeler, C., Kyu, A., & Brown, A. C. (2020). Neonatal Fibrin Scaffolds Promote Enhanced Cell Adhesion, Migration, and Wound Healing In Vivo Compared to Adult Fibrin Scaffolds. CELLULAR AND MOLECULAR BIOENGINEERING. https://doi.org/10.1007/s12195-020-00620-5

Nandi, S., Sommerville, L., Nellenbach, K., Mihalko, E., Erb, M., Freytes, D. O., … Brown, A. C. (2020). Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 577, 406–418. https://doi.org/10.1016/j.jcis.2020.05.088

Chester, D., Theetharappan, P., Ngobili, T., Daniele, M., & Brown, A. C. (2020). Ultrasonic Microplotting of Microgel Bioinks. ACS APPLIED MATERIALS & INTERFACES, 12(42), 47309–47319. https://doi.org/10.1021/acsami.0c15056

Nandi, S., Mohanty, K., Nellenbach, K., Erb, M., Muller, M., & Brown, A. C. (2020). Ultrasound Enhanced Synthetic Platelet Therapy for Augmented Wound Repair. ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(5), 3026–3036. https://doi.org/10.1021/acsbiomaterials.9b01976

Brown, A. C., Lavik, E., & Stabenfeldt, S. E. (2019). [Review of Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen]. BIOCONJUGATE CHEMISTRY, 30(7), 1951–1956. https://doi.org/10.1021/acs.bioconjchem.9b00360

Muhamed, I., Sproul, E. P., Ligler, F. S., & Brown, A. C. (2019). Fibrin Nanoparticles Coupled with Keratinocyte Growth Factor Enhance the Dermal Wound-Healing Rate. ACS APPLIED MATERIALS & INTERFACES, 11(4), 3771–3780. https://doi.org/10.1021/acsami.8b21056

Brown, A. C., & Levy, J. H. (2019, September). Maintaining Hemostatic Balance in Treating Disseminated Intravascular Coagulation. ANESTHESIOLOGY, Vol. 131, pp. 459–461. https://doi.org/10.1097/ALN.0000000000002862

Nandi, S., Sproul, E. P., Nellenbach, K., Erb, M., Gaffney, L., Freytes, D. O., & Brown, A. C. (2019). Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes. BIOMATERIALS SCIENCE, 7(2), 669–682. https://doi.org/10.1039/c8bm01201f

Chester, D., Marrow, E. A., Daniele, M. A., & Brown, A. C. (2019). Wound Healing and the Host Response in Regenerative Engineering. ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 1, pp. 707–718. https://doi.org/10.1016/B978-0-12-801238-3.99896-9

Sproul, E. P., Nandi, S., Roosa, C., Schreck, L., & Brown, A. C. (2018). Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes. ADVANCED BIOSYSTEMS, 2(10). https://doi.org/10.1002/adbi.201800042

Welsch, N., Brown, A. C., Barker, T. H., & Lyon, L. A. (2018). Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels. COLLOIDS AND SURFACES B-BIOINTERFACES, 166, 89–97. https://doi.org/10.1016/j.colsurfb.2018.03.003

Sproul, E., Nandi, S., & Brown, A. (2018). Fibrin biomaterials for tissue regeneration and repair. PEPTIDES AND PROTEINS AS BIOMATERIALS FOR TISSUE REGENERATION AND REPAIR, pp. 151–173. https://doi.org/10.1016/b978-0-08-100803-4.00006-1

Hardy, E. T., Wang, Y. J., Iyer, S., Mannino, R. G., Sakurai, Y., Barker, T. H., … Lam, W. A. (2018). Interdigitated microelectronic bandage augments hemostasis and clot formation at low applied voltage in vitro and in vivo. LAB ON A CHIP, 18(19), 2985–2993. https://doi.org/10.1039/c8lc00573g

Mihalko, E. P., & Brown, A. C. (2018). [Review of Material Strategies for Modulating Epithelial to Mesenchymal Transitions]. ACS BIOMATERIALS SCIENCE & ENGINEERING, 4(4), 1149–1161. https://doi.org/10.1021/acsbiomaterials.6b00751

Joshi, A., Nandi, S., Chester, D., Brown, A. C., & Muller, M. (2018). Study of Poly(N-isopropylacrylamide-co-acrylic acid) (pNIPAM) Microgel Particle Induced Deformations of Tissue-Mimicking Phantom by Ultrasound Stimulation. LANGMUIR, 34(4), 1457–1465. https://doi.org/10.1021/acs.langmuir.7b02801

Mihalko, E., Huang, K., Sproul, E., Cheng, K., & Brown, A. C. (2018). Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic. ACS Nano, 12(8), 7826–7837. https://doi.org/10.1021/ACSNANO.8B01977

Tang, J., Su, T., Huang, K., Dinh, P.-U., Wang, Z., Vandergriff, A., … Cheng, K. (2018). Targeted repair of heart injury by stem cells fused with platelet nanovesicles. NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26. https://doi.org/10.1038/s41551-017-0182-x

Chester, D., Kathard, R., Nortey, J., Nellenbach, K., & Brown, A. C. (2018). Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses. BIOMATERIALS, 185, 371–382. https://doi.org/10.1016/j.biomaterials.2018.09.012

Nandi, S., & Brown, A. C. (2017). Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, (126). https://doi.org/10.3791/56099

Cao, L., Nicosia, J., Larouche, J., Zhang, Y., Bachman, H., Brown, A. C., … Barker, T. H. (2017). Detection of an Integrin-Binding Mechanoswitch within Fibronectin during Tissue Formation and Fibrosis. ACS NANO, 11(7), 7110–7117. https://doi.org/10.1021/acsnano.7b02755

Nellenbach, K., & Brown, A. C. (2017). Peptide Mimetic Drugs for Modulating Thrombosis and Hemostasis. DRUG DEVELOPMENT RESEARCH, 78(6), 236–244. https://doi.org/10.1002/ddr.21407

Myers, D. R., Qiu, Y., Fay, M. E., Tennenbaum, M., Chester, D., Cuadrado, J., … Lam, W. A. (2017). Single-platelet nanomechanics measured by high-throughput cytometry. NATURE MATERIALS, 16(2), 230–235. https://doi.org/10.1038/nmat4772

Chester, D., & Brown, A. C. (2017). [Review of The role of biophysical properties of provisional matrix proteins in wound repair]. MATRIX BIOLOGY, 60-61, 124–140. https://doi.org/10.1016/j.matbio.2016.08.004

Brown, A. C., Hannan, R. H., Timmins, L. H., Fernandez, J. D., Barker, T. H., & Guzzetta, N. A. (2016, May). Fibrin Network Changes in Neonates after Cardiopulmonary Bypass. ANESTHESIOLOGY, Vol. 124, pp. 1021–1031. https://doi.org/10.1097/aln.0000000000001058

Nandi, S., & Brown, A. C. (2016). [Review of Platelet-mimetic strategies for modulating the wound environment and inflammatory responses]. EXPERIMENTAL BIOLOGY AND MEDICINE, 241(10), 1138–1148. https://doi.org/10.1177/1535370216647126

Karumbaiah, L., Enam, S. F., Brown, A. C., Saxena, T., Betancur, M. I., Barker, T. H., & Bellamkonda, R. V. (2015). Chondroitin Sulfate Glycosaminoglycan Hydrogels Create Endogenous Niches for Neural Stem Cells. BIOCONJUGATE CHEMISTRY, 26(12), 2336–2349. https://doi.org/10.1021/acs.bioconjchem.5b00397

Brown, A. C., Dysart, M. M., Clarke, K. C., Stabenfeldt, S. E., & Barker, T. H. (2015). Integrin alpha 3 beta 1 binding to fibronectin is dependent on the ninth type III repeat. Journal of Biological Chemistry, 290(42), 25534–25547. https://doi.org/10.1074/jbc.m115.656702

Brown, A. C., Baker, S. R., Douglas, A. M., Keating, M., Alvarez-Elizondo, M. B., Botvinick, E. L., … Barker, T. H. (2015). Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties. Biomaterials, 49, 27–36. https://doi.org/10.1016/J.BIOMATERIALS.2015.01.010

Bachman, H., Brown, A. C., Clarke, K. C., Dhada, K. S., Douglas, A., Hansen, C. E., … Lyon, L. A. (2015). Ultrasoft, highly deformable microgels. Soft Matter, 11(10), 2018–2028. https://doi.org/10.1039/C5SM00047E

Kim, J., Park, Y., Brown, A. C., & Lyon, L. A. (2014). Direct observation of ligand-induced receptor dimerization with a bioresponsive hydrogel. RSC Advances, 4(110), 65173–65175. https://doi.org/10.1039/C4RA13251C

Baker, S., Carson-Brown, A., Guthold, M., & Barker, T. (2014). Fibrin Fibers: Blocking the B:B Knob-Pocket Interaction. Biophysical Journal, 106(2), 614a. https://doi.org/10.1016/J.BPJ.2013.11.3399

Brown, A. C., & Barker, T. H. (2014). Fibrin-based biomaterials: Modulation of macroscopic properties through rational design at the molecular level. Acta Biomaterialia, 10(4), 1502–1514. https://doi.org/10.1016/J.ACTBIO.2013.09.008

Bryksin, A. V., Brown, A. C., Baksh, M. M., Finn, M. G., & Barker, T. H. (2014). Learning from nature – Novel synthetic biology approaches for biomaterial design. Acta Biomaterialia, 10(4), 1761–1769. https://doi.org/10.1016/J.ACTBIO.2014.01.019

Qiu, Y., Brown, A. C., Myers, D. R., Sakurai, Y., Mannino, R. G., Tran, R., … Lam, W. A. (2014). Platelet mechanosensing of substrate stiffness during clot formation mediates adhesion, spreading, and activation. Proceedings of the National Academy of Sciences, 111(40), 14430–14435. https://doi.org/10.1073/PNAS.1322917111

Brown, A. C., Stabenfeldt, S. E., Ahn, B., Hannan, R. T., Dhada, K. S., Herman, E. S., … Barker, T. H. (2014). Ultrasoft microgels displaying emergent platelet-like behaviours. Nature Materials, 13(12), 1108–1114. https://doi.org/10.1038/NMAT4066

Clarke, K. C., Douglas, A. M., Brown, A. C., Barker, T. H., & Lyon, L. A. (2013). Colloid-matrix assemblies in regenerative medicine. Current Opinion in Colloid & Interface Science, 18(5), 393–405. https://doi.org/10.1016/J.COCIS.2013.07.004

Brown, A. C., Fiore, V. F., Sulchek, T. A., & Barker, T. H. (2013). Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions. The Journal of Pathology, 229(1), 25–35. https://doi.org/10.1002/path.4114

Baker, S., Carson Brown, A., Barker, T., & Guthold, M. (2013). The Mechanical Properties of Modified Fibrin Fibers: Blocking the B-b Knob-Pocket Interaction. Biophysical Journal, 104(2), 512a–513a. https://doi.org/10.1016/j.bpj.2012.11.2831

Markowski, M. C., Brown, A. C., & Barker, T. H. (2012). Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues. Journal of Biomedical Materials Research Part A, 100A(8), 2119–2127. https://doi.org/10.1002/jbm.a.34068

Park, E. S., Brown, A. C., DiFeo, M. A., Barker, T. H., & Lu, H. (2010). Continuously perfused, non-cross-contaminating microfluidic chamber array for studying cellular responses to orthogonal combinations of matrix and soluble signals. Lab Chip, 10(5), 571–580. https://doi.org/10.1039/b919294h