Annabel Meade

College of Sciences

Works (4)

Updated: October 2nd, 2025 05:06

2025 article

Characterizing variability and uncertainty for parameter subset selection in PBPK models

Schacht, C. M., Kapraun, D. F., Meade, A. E., Bernstein, A. S., Tran, H. T., & Schlosser, P. M. (2025, July 30). Toxicological Sciences.

By: C. Schacht*, D. Kapraun*, A. Meade*, A. Bernstein*, H. Tran n  & P. Schlosser*

author keywords: physiologically based pharmacokinetics; mathematical modeling; human risk assessment; uncertainty quantification; sensitivity analysis
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Effects and risks of endocrine disrupting chemicals; Statistical Methods in Clinical Trials; Probabilistic and Robust Engineering Design; Control Systems and Identification; Fault Detection and Control Systems
Sources: Web Of Science, ORCID
Added: July 30, 2025

2024 article

Evaluating the impact of anatomical and physiological variability on human equivalent doses using PBPK models

Schacht, C. M., Meade, A. E., Bernstein, A. S., Prasad, B., Schlosser, P. M., Tran, H. T., & Kapraun, D. F. (2024, May 24). Toxicological Sciences, Vol. 5.

By: C. Schacht*, A. Meade*, A. Bernstein*, B. Prasad*, P. Schlosser*, H. Tran n , D. Kapraun*

MeSH headings : Humans; Models, Biological; Animals; Risk Assessment; Chloroform / pharmacokinetics; Uncertainty; Tissue Distribution; Dose-Response Relationship, Drug
topics (OpenAlex): Carcinogens and Genotoxicity Assessment; Effects and risks of endocrine disrupting chemicals; Pesticide Residue Analysis and Safety
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2024

2019 article

Estimation of probability distributions of parameters using aggregate population data: analysis of a CAR T-cell cancer model

Schacht, C., Meade, A., Banks, H. T., Enderling, H., & Abate-Daga, D. (2019, January 1). Mathematical Biosciences & Engineering.

By: C. Schacht n, A. Meade n, H. Banks n, H. Enderling * & D. Abate-Daga *

author keywords: aggregate data; CAR T-cell therapy; cancer model; inverse problems; design of experiments
MeSH headings : Algorithms; Animals; Computer Simulation; Humans; Immunotherapy, Adoptive; Mice; Models, Theoretical; Neoplasm Transplantation; Neoplasms, Experimental / therapy; Population Dynamics; Probability; Receptors, Chimeric Antigen / chemistry; Reproducibility of Results; T-Lymphocytes / cytology
topics (OpenAlex): Gene Regulatory Network Analysis; Mathematical Biology Tumor Growth; Monoclonal and Polyclonal Antibodies Research
TL;DR: First elementary computations on the question how much data is needed for successful estimation of probability distributions are carried out on a class of CAR T-call cancer models in mice. (via Semantic Scholar)
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Source: Web Of Science
Added: October 14, 2019

2019 article

Parameter estimation using aggregate data

Banks, H. T., Meade, A. E., Schacht, C., Catenacci, J., Thompson, W. C., Abate-Daga, D., & Enderling, H. (2019, August 22). Applied Mathematics Letters.

By: H. Banks*, A. Meade*, C. Schacht*, J. Catenacci*, W. Thompson*, D. Abate-Daga *, H. Enderling *

author keywords: Uncertainty quantification; Parameter estimation; CAR T cancer therapy
topics (OpenAlex): CAR-T cell therapy research; Monoclonal and Polyclonal Antibodies Research; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: These issues are discussed in the context of a mathematical model to determine T-cell behavior with cancer chimeric antigen receptor (CAR) therapies where during the collection of data cancerous mice are sacrificed at each measurement time. (via Semantic Scholar)
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Source: Web Of Science
Added: November 25, 2019

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