@article{armitano-lago_evans-pickett_davis-wilson_munsch_longobardi_willcockson_schwartz_franz_pietrosimone_2024, title={Modifying loading during gait leads to biochemical changes in serum cartilage oligomeric matrix protein concentrations in a subgroup of individuals with anterior cruciate ligament reconstruction}, ISSN={["1434-9949"]}, DOI={10.1007/s10067-024-06898-4}, journal={CLINICAL RHEUMATOLOGY}, author={Armitano-Lago, Cortney and Evans-Pickett, Alyssa and Davis-Wilson, Hope and Munsch, Amanda and Longobardi, Lara and Willcockson, Helen and Schwartz, Todd A. and Franz, Jason R. and Pietrosimone, Brian}, year={2024}, month={Feb} }
 @article{bjornsen_berkoff_blackburn_davis-wilson_evans-pickett_franz_harkey_horton_lisee_luc-harkey_et al._2024, title={Sustained Limb-Level Loading: A Ground Reaction Force Phenotype Common to Individuals at High Risk for and Those With Knee Osteoarthritis}, ISSN={["2326-5205"]}, DOI={10.1002/art.42744}, abstractNote={ObjectiveThe objective of this study was to compare the vertical (vGRF), anterior‐posterior (apGRF), and medial‐lateral (mlGRF) ground reaction force (GRF) profiles throughout the stance phase of gait (1) between individuals 6 to 12 months post–anterior cruciate ligament reconstruction (ACLR) and uninjured matched controls and (2) between ACLR and individuals with differing radiographic severities of knee osteoarthritis (KOA), defined as Kellgren and Lawrence (KL) grades KL2, KL3, and KL4.}, journal={ARTHRITIS & RHEUMATOLOGY}, author={Bjornsen, Elizabeth and Berkoff, David and Blackburn, J. Troy and Davis-Wilson, Hope and Evans-Pickett, Alyssa and Franz, Jason R. and Harkey, Matthew S. and Horton, W. Zachary and Lisee, Caroline and Luc-Harkey, Brittney and et al.}, year={2024}, month={Jan} }
 @article{lisee_evans-pickett_davis-wilson_munsch_longobardi_schwartz_lalush_franz_pietrosimone_2023, title={Delayed cartilage oligomeric matrix protein response to loading is associated with femoral cartilage composition post-ACLR}, ISSN={["1439-6327"]}, DOI={10.1007/s00421-023-05253-w}, abstractNote={{"Label"=>"PURPOSE", "NlmCategory"=>"OBJECTIVE"} To determine associations between immediate and delayed response of serum cartilage oligomeric matrix protein (sCOMP) to loading (i.e., 3000 walking steps) and femoral cartilage interlimb T1ρ relaxation times in individual's post-anterior cruciate ligament reconstruction (ACLR). {"Label"=>"METHODS", "NlmCategory"=>"METHODS"} This cross-sectional study included 20 individuals 6-12 months following primary ACLR (65% female, 20.5 ± 4.0 years old, 24.9 ± 3.0 kg/m {"sup"=>"2"} , 7.3 ± 1.5 months post-ACLR). Serum samples were collected prior to, immediately following, and 3.5 h following walking 3000 steps on a treadmill at habitual walking speed. sCOMP concentrations were processed using enzyme-linked immunosorbent assays. Immediate and delayed absolute sCOMP responses to loading were evaluated immediately and 3.5 h post-walking, respectively. Participants underwent bilateral magnetic resonance imaging with T1ρ sequences to calculate resting femoral cartilage interlimb T1ρ relaxation time ratios between limbs (i.e., ACLR/Uninjured limb). Linear regression models were fitted to determine associations between sCOMP response to loading and femoral cartilage T1ρ outcomes controlling for pre-loading sCOMP concentrations. {"Label"=>"RESULTS", "NlmCategory"=>"RESULTS"} Greater increases in delayed sCOMP response to loading were associated with greater lateral (∆R {"sup"=>"2"}  = 0.29, p = 0.02) but not medial (∆R {"sup"=>"2"}  < 0.01, p = 0.99) femoral cartilage interlimb T1ρ ratios. Associations between immediate sCOMP response to loading with femoral cartilage interlimb T1ρ ratios were weak and non-significant (∆R {"sup"=>"2"}  range = 0.02-0.09, p range = 0.21-0.58). {"Label"=>"CONCLUSION", "NlmCategory"=>"CONCLUSIONS"} Greater delayed sCOMP response to loading, a biomarker of cartilage breakdown, is associated with worse lateral femoral cartilage composition in the ACLR limb compared to the uninjured limb. Delayed sCOMP response to loading may be a more indicative metabolic indicator linked to deleterious changes in composition than immediate sCOMP response.}, journal={EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY}, author={Lisee, Caroline and Evans-Pickett, Alyssa and Davis-Wilson, Hope and Munsch, Amanda E. and Longobardi, Lara and Schwartz, Todd A. and Lalush, David and Franz, Jason R. and Pietrosimone, Brian}, year={2023}, month={Jun} }
 @article{bjornsen_davis-wilson_evans-picket_horton_lisee_munsch_nissman_blackburn_franz_pietrosimone_2023, title={Knee kinetics and the medial femoral cartilage cross-sectional area response to loading in indviduals with anterior cruciate ligament reconstruction}, volume={105}, ISSN={["1879-1271"]}, DOI={10.1016/j.clinbiomech.2023.105979}, abstractNote={Ultrasonography is capable of detecting morphological changes in femoral articular cartilage cross-sectional area in response to an acute bout of walking; yet, the response of femoral cartilage cross-sectional area varies between individuals. It is hypothesized that differences in joint kinetics may influence the response of cartilage to a standardized walking protocol. Therefore, the study purpose was to compare internal knee abduction and extension moments between individuals with anterior cruciate ligament reconstruction who demonstrate an acute increase, decrease, or unchanged medial femoral cross-sectional area response following 3000 steps.The medial femoral cartilage in the anterior cruciate ligament reconstructed limb was assessed with ultrasonography before and immediately following 3000 steps of treadmill walking. Knee joint moments were calculated in the anterior cruciate ligament reconstructed limb and compared between groups throughout the stance phase of gait using linear regression and functional, mixed effects waveform analyses.No associations between peak knee joint moments and the cross-sectional area response were observed. The group that demonstrated an acute cross-sectional area increase exhibited 1) lower knee abduction moments in early stance in comparison to the group that exhibited a decreased cross-sectional area response; and 2) greater knee extension moments in early stance in comparison to the group with an unchanged cross-sectional area response.The propensity of femoral cartilage to acutely increase cross-sectional area in response to walking is consistent with less-dynamic knee abduction and knee extension moment profiles.}, journal={CLINICAL BIOMECHANICS}, author={Bjornsen, Elizabeth and Davis-Wilson, Hope and Evans-Picket, Alyssa and Horton, W. Zachary and Lisee, Caroline and Munsch, Amanda E. and Nissman, Daniel and Blackburn, J. Troy and Franz, Jason R. and Pietrosimone, Brian}, year={2023}, month={May} }
 @article{munsch_evans-pickett_davis-wilson_pietrosimone_franz_2022, title={Quadriceps Muscle Action and Association With Knee Joint Biomechanics in Individuals with Anterior Cruciate Ligament Reconstruction}, volume={38}, ISSN={["1543-2688"]}, DOI={10.1123/jab.2021-0381Inc}, number={5}, journal={JOURNAL OF APPLIED BIOMECHANICS}, author={Munsch, Amanda E. and Evans-Pickett, Alyssa and Davis-Wilson, Hope and Pietrosimone, Brian and Franz, Jason R.}, year={2022}, month={Oct}, pages={328–335} }
 @article{munsch_pietrosimone_franz_2020, title={The effects of knee extensor moment biofeedback on gait biomechanics and quadriceps contractile behavior}, volume={8}, ISSN={["2167-8359"]}, DOI={10.7717/peerj.9509}, abstractNote={Individuals with knee joint pathologies exhibit quadriceps dysfunction that, during walking, manifests as smaller peak knee extensor moment (pKEM) and reduced knee flexion excursion. These changes persist despite muscle strengthening and may alter stance phase knee joint loading considered relevant to osteoarthritis risk. Novel rehabilitation strategies that more directly augment quadriceps mechanical output during functional movements are needed to reduce this risk. As an important first step, we tested the efficacy of real-time biofeedback during walking to prescribe changes of ±20% and ±40% of normal walking pKEM values in 11 uninjured young adults. We simultaneously recorded knee joint kinematics, ground reaction forces, and, via ultrasound, vastus lateralis (VL) fascicle length change behavior. Participants successfully responded to real-time biofeedback and averaged up to 55% larger and 51% smaller than normal pKEM values with concomitant and potentially favorable changes in knee flexion excursion. While the VL muscle-tendon unit (MTU) lengthened, VL fascicles accommodated weight acceptance during walking largely through isometric, or even slight concentric, rather than eccentric action as is commonly presumed. Targeted pKEM biofeedback may be a useful rehabilitative and/or scientific tool to elicit desirable changes in knee joint biomechanics considered relevant to the development of osteoarthritis.}, journal={PEERJ}, author={Munsch, Amanda E. and Pietrosimone, Brian and Franz, Jason R.}, year={2020}, month={Jul} }