@misc{sheridan_brown_2023, title={Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies}, volume={2023}, ISSN={["1932-7005"]}, DOI={10.1155/2023/6117810}, abstractNote={Myocardial infarction, stroke, and pulmonary embolism are all deadly conditions associated with excessive thrombus formation. Standard treatment for these conditions involves systemic delivery of thrombolytic agents to break up clots and restore blood flow; however, this treatment can impact the hemostatic balance in other parts of the vasculature, which can lead to excessive bleeding. To avoid this potential danger, targeted thrombolytic treatments that can successfully target thrombi and release an effective therapeutic load are necessary. Because activated platelets and fibrin make up a large proportion of clots, these two components provide ample opportunities for targeting. This review will highlight potential thrombus targeting mechanisms as well as recent advances in thrombolytic therapies which utilize blood cells and clotting proteins to effectively target and lyse clots.}, journal={JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE}, author={Sheridan, Anastasia and Brown, Ashley C.}, year={2023}, month={Feb} }
 @article{boger_sheridan_ziegler_blikslager_2022, title={Mechanisms and modeling of wound repair in the intestinal epithelium}, volume={6}, ISSN={["2168-8370"]}, url={https://doi.org/10.1080/21688370.2022.2087454}, DOI={10.1080/21688370.2022.2087454}, abstractNote={ABSTRACT The intestinal epithelial barrier is susceptible to injury from insults, such as ischemia or infectious disease. The epithelium’s ability to repair wounded regions is critical to maintaining barrier integrity. Mechanisms of intestinal epithelial repair can be studied with models that recapitulate the in vivo environment. This review focuses on in vitro injury models and intestinal cell lines utilized in such systems. The formation of artificial wounds in a controlled environment allows for the exploration of reparative physiology in cell lines modeling diverse aspects of intestinal physiology. Specifically, the use of intestinal cell lines, IPEC-J2, Caco-2, T-84, HT-29, and IEC-6, to model intestinal epithelium is discussed. Understanding the unique systems available for creating intestinal injury and the differences in monolayers used for in vitro work is essential for designing studies that properly capture relevant physiology for the study of intestinal wound repair.}, journal={TISSUE BARRIERS}, author={Boger, Kasey D. and Sheridan, Ana E. and Ziegler, Amanda L. and Blikslager, Anthony T.}, year={2022}, month={Jun} }