Alba Frias

Also known as: Alba Frias

Works (18)

Updated: March 4th, 2025 21:06

2025 article

Influence of Sequencing Technology on Pangenome-level Analysis and Detection of Antimicrobial Resistance Genes in ESKAPE Pathogens

Frias-De-Diego, A., Jara, M., & Lanzas, C. (2025, January 11).

By: A. Frias-De-Diego  n, M. Jara  n & C. Lanzas n 

Source: ORCID
Added: January 11, 2025

2023 journal article

A rapid, high-throughput, viral infectivity assay using automated brightfield microscopy with machine learning

SLAS Technology, 28(5), 324–333.

By: R. Dodkins *, J. Delaney*, T. Overton n, F. Scholle n , A. Frias-De-Diego  n, E. Crisci n , N. Huq, I. Jordan ...

author keywords: Viral infectivity assay; Antiviral screening; Brightfield microscopy; Label-free assays; Cell-based assays; Machine learning; Convolutional neural networks
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: July 13, 2023

2022 journal article

Effect of BIO-PLYTM, a Platelet-Rich Plasma Derived Biologic on PRRSV-2-Infected Macrophages

Viruses, 14(12), 2666.

By: A. Frias-De-Diego  n, J. Gilbertie*, F. Scholle n , S. Dejarnette n & E. Crisci n 

author keywords: antivirals; biologic; porcine macrophages; PRRSV
MeSH headings : Humans; Swine; Animals; Horses; Porcine respiratory and reproductive syndrome virus; Porcine Reproductive and Respiratory Syndrome / prevention & control; Macrophages; Biological Products
TL;DR: The results show that BIO-PLYTM significantly reduces the amount of PRRSV viral load determined by RT-qPCR and the number of infectious viral particles measured by TCID50 in infected porcine alveolar and parenchymal macrophages. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: November 29, 2022

2022 journal article

Heterologous vaccine immunogenicity, efficacy, and immune correlates of protection of a modified-live virus porcine reproductive and respiratory syndrome virus vaccine

FRONTIERS IN MICROBIOLOGY, 13.

By: J. Proctor n, I. Wolf n, D. Brodsky n, L. Cortes n, A. Frias-De-Diego  n, G. Almond n , E. Crisci n , T. Negrão Watanabe n, J. Hammer *, T. Käser n

Contributors: E. Crisci n 

author keywords: porcine reproductive and respiratory syndrome virus (PRRSV); correlates of protection (CoP); vaccination; swine; immunity; pig
TL;DR: Overall, the Prevacent elicited various degrees of efficacy and immunogenicity against four heterologous and phylogenetically distant strains of PRRSV-2, and correlation analyses revealed that the (non-PRRSV strain-specific) serum IgG levels and the PRRSv strain- specific CD4 T-cell response were the best immune correlates of protection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 25, 2022

2022 journal article

The health benefits of selenium in food animals: a review

Journal of Animal Science and Biotechnology, 13(1), 58.

By: B. Pecoraro n, D. Leal n, A. Frias-De-Diego  n, M. Browning n, J. Odle n  & E. Crisci n 

author keywords: Antimicrobial; Antioxidant; Food animals; Immunomodulation; Pig; Selenium
TL;DR: The review demonstrates the gaps in knowledge pertaining to the use of selenium as an antiviral, underscoring the need for further in vivo and in vitro studies, particularly in pigs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: May 13, 2022

2022 journal article

Use of Crystal Violet to Improve Visual Cytopathic Effect-based Reading for Viral Titration using TCID50 Assays

Journal of Visualized Experiments, 2(180).

By: A. Frias-De-Diego  n & E. Crisci n 

MeSH headings : Animals; Cell Line; Cytopathogenic Effect, Viral; Gentian Violet; Influenza A virus; Reading; Swine
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4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 13, 2022

2021 journal article

A Liquid Metal Mediated Metallic Coating for Antimicrobial and Antiviral Fabrics

Kwon, K. Y., Cheeseman, S., Frias-De-Diego, A., Hong, H., Yang, J., Jung, W., … Kim, T.-il. (2021, September 22). ADVANCED MATERIALS, Vol. 9.

By: K. Kwon n, S. Cheeseman *, A. Frias‐De‐Diego  n, H. Hong*, J. Yang n, W. Jung *, H. Yin *, B. Murdoch * ...

author keywords: antimicrobial; antiviral; galvanic replacement; liquid metal fabric coating
MeSH headings : Alloys / chemistry; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Antiviral Agents / chemistry; Antiviral Agents / pharmacology; Bacteria / drug effects; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacology; Copper / chemistry; Fungi / drug effects; Gallium / chemistry; Textiles / analysis; Viruses / drug effects
TL;DR: The presence of the LMCu particles can eradicate over 99% of pathogens within 5 min, which is significantly more effective than control samples coated with only Cu, and is promising for generating robust antibacterial, antifungal, and antiviral fabrics and surfaces. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: September 28, 2021

2021 journal article

Impact of changes of horse movement regulations on the risks of equine infectious anemia: A risk assessment approach

PREVENTIVE VETERINARY MEDICINE, 190.

By: G. Machado n , L. Corbellini *, A. Frias-De-Diego  n, G. Dieh, D. Santos *, M. Jara n, E. Costa *

Contributors: G. Machado n , L. Corbellini *, A. Frias-De-Diego  n, G. Dieh, D. Santos *, M. Jara n, E. Freitas Costa *

author keywords: Transboundary animal disease; Stochastic models; Horse; Surveillance; Policy
MeSH headings : Animals; Antibodies, Viral; Brazil / epidemiology; Equine Infectious Anemia / epidemiology; Horse Diseases / epidemiology; Horse Diseases / virology; Horses; Infectious Anemia Virus, Equine; Risk Assessment; Transportation
TL;DR: The results demonstrated the importance of constant reviews of disease control programs and provided quantitative-based knowledge for decision-makers in official veterinary services. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2021

2021 journal article

The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus

Frontiers in Immunology, 12.

By: A. Kick  n, A. Amaral n, A. Frias-De-Diego  n, L. Cortes n, J. Fogle n, E. Crisci n , G. Almond n , T. Käser n

author keywords: adaptive immunity; humoral immunity; neutralizing antibodies; IgA; IgG; porcine reproductive and respiratory syndrome virus
MeSH headings : Animals; Antibodies, Neutralizing / blood; Flow Cytometry / methods; Immunity, Humoral / immunology; Immunoglobulin A / analysis; Immunoglobulin A / immunology; Immunoglobulin G / blood; Nasal Mucosa / immunology; Nasal Mucosa / virology; Porcine Reproductive and Respiratory Syndrome / immunology; Porcine respiratory and reproductive syndrome virus / immunology; Swine; Vaccination; Viral Vaccines / immunology; Viremia / immunology; Viremia / virology
TL;DR: This study improves the understanding of the relationship between local and systemic infections and the humoral immune response induced by PRRSV-2 infection or MLV vaccination and provides novel insights into the timeline of the development of homologous and heterologous NA levels – by bothMLV vaccination or infection with two strains from the currently prevalent PRRSv-2 lineage 1. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 29, 2021

2021 journal article

Whole Genome or Single Genes? A Phylodynamic and Bibliometric Analysis of PRRSV

Frontiers in Veterinary Science, 8.

By: A. Frias-De-Diego  n, M. Jara n, B. Pecoraro n & E. Crisci n 

author keywords: bibliometrics; phylodynamics; pig; PRRSV; ORF5; whole genome
TL;DR: This study provides an exploration of the two main phylogenetic research lines applied for PRRSV evolution, as well as an example of the differences found when both methods are applied to the same database. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: July 19, 2021

2020 journal article

A Century of Swine Influenza: Is It Really Just about the Pigs?

Veterinary Sciences, 7(4), 189.

By: A. Frias-De-Diego  n, R. Posey n , B. Pecoraro n, R. Carnevale *, A. Beaty n & E. Crisci n 

author keywords: bibliometrics; swine influenza virus; influenza variants; GenBank; global health
TL;DR: It is observed that the 2009 H1N1 human pandemic created an important bias in SwIV research driven by an increase in human publications on the IV of swine origin and will serve as a guidance for future search strategies in Sw IV research. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: December 1, 2020

2020 journal article

Nairobi Sheep Disease Virus: A Historical and Epidemiological Perspective

FRONTIERS IN VETERINARY SCIENCE, 7.

By: S. Krasteva n, M. Jara n, A. Frias-De-Diego  n & G. Machado n 

Contributors: S. Krasteva n, M. Jara n, A. Frias-De-Diego  n & G. Machado n 

author keywords: ecological niche model; systematic review; spatial distribution; small ruminants; tick-borne; disease surveillance
TL;DR: It is critical to investigate the epidemiology of NSDv in order to promote better allocation of resources to control its spread in regions that are more at risk, as climate change will favor emergence of such vector-borne diseases in areas with dense small ruminant populations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 31, 2020

2020 journal article

Phylogeography of Equine Infectious Anemia Virus

FRONTIERS IN ECOLOGY AND EVOLUTION, 8.

By: M. Jara n, A. Frias-De-Diego  n & G. Machado n 

Contributors: M. Jara n, A. Frias-De-Diego  n & G. Machado n 

author keywords: equine anemia; infectious diseases; molecular epidemiology; phylodynamics; viral evolution
TL;DR: This study provides a historical geographic mapping of the EIAV linages’ spread patterns, and identified important asymmetry between the current research effort and the availability of genetic data which restricted the abilities to quantify for example the time frame of virus dispersal. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 15, 2020

2019 journal article

Papillomavirus in Wildlife

FRONTIERS IN ECOLOGY AND EVOLUTION, 7.

By: A. Frias-De-Diego  n, M. Jara n & L. Escobar *

author keywords: dispersal; evolution; global; lineage; papillomavirus; phylogeography; viral epidemiology; wildlife
TL;DR: An overview of papillomavirus (WPV) suggests that WPV are a promising host-pathogen system to untangle questions regarding co-evolution due to its large geographic distribution and occurrence in a wide variety of aquatic and terrestrial wildlife species. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2019

2019 journal article

Relation of reproductive disturbance in sheep and Leptospira interrogans serovar Icterohaemorrhagiae infection: Impacts on cellular oxidation status

MICROBIAL PATHOGENESIS, 130, 65–70.

By: A. Silva *, C. Souza *, M. Baldissera *, A. Von Laer *, L. Lovato *, J. Sarturi *, G. Herrmann *, A. Moura * ...

Contributors: A. Silva *, C. Souza *, M. Baldissera *, A. Von Laer *, L. Lovato *, J. Sarturi *, G. Herrmann *, A. Moura * ...

author keywords: Leptospirosis; Disease pathophysiology; Oxidative stress
MeSH headings : Animals; Brazil; Brucellosis / complications; Brucellosis / veterinary; Creatine Kinase / blood; Female; Genital Diseases, Female / pathology; Genital Diseases, Female / veterinary; Glutathione Peroxidase / blood; Glutathione Transferase / blood; Leptospira interrogans serovar icterohaemorrhagiae / classification; Leptospira interrogans serovar icterohaemorrhagiae / growth & development; Leptospirosis / complications; Leptospirosis / pathology; Leptospirosis / veterinary; Oxidative Stress; Reactive Oxygen Species / blood; Serotyping; Sheep; Sheep Diseases / pathology; Superoxide Dismutase / blood
TL;DR: The region of Planalto Serrano de Santa Catarina with a high occurrence levels of sheep infected by L. interrogans serovar Icterohaemorrhagiae is shown, from which animals with high titrations present oxidative stress elicited by excessive ROS production, triggering the stimulation of antioxidant systems to counter this excess. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 28, 2019

2019 journal article

Spatial distribution and spread potential of sixteen <i>Leptospira</i> serovars in a subtropical region of Brazil

Spatial distribution and spread potential of sixteen Leptospira serovars in a subtropical region of Brazil. Transboundary and Emerging Diseases, 66(6), 2482–2495.

By: M. Jara  n, L. Escobar *, R. Rodriges, A. Frias‐De‐Diego  n, J. Sanhueza * & G. Machado n 

Contributors: M. Jara  n, L. Escobar *, R. Rodriges, A. Frias-De-Diego  n, J. Sanhueza * & G. Machado n 

author keywords: disease distribution; ecological similarities; environmental; Leptospira; NicheA; spatial analysis; spread; zoonotic
MeSH headings : Animals; Brazil / epidemiology; Ecosystem; Hydrogen-Ion Concentration; Leptospira / isolation & purification; Leptospirosis / epidemiology; Seroepidemiologic Studies; Serogroup; Soil / chemistry; Temperature; Tropical Climate
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Source: ORCID
Added: August 18, 2019

2019 article

Tracing foot-and-mouth disease virus phylogeographical patterns and transmission dynamics

Jara, M., Frias-De-Diego, A., Dellicour, S., Baele, G., & Machado, G. (2019, March 28). BioRxiv, Vol. 3.

By: M. Jara  n, A. Frias-De-Diego  n, S. Dellicour *, G. Baele * & G. Machado n 

Contributors: M. Jara  n, A. Frias-De-Diego  n, S. Dellicour *, G. Baele * & G. Machado n 

TL;DR: This study provides significant insights into the spatiotemporal dynamics of the global circulation of FMDV serotypes, by characterizing the viral routes of spread at serotype level, especially uncovering the importance of host species for each serotype in the evolution and spread of F MDV which further improve future decisions for more efficient control and eradication. (via Semantic Scholar)
Source: ORCID
Added: March 29, 2019

2018 journal article

The Macroecology of Chemical Communication in Lizards: Do Climatic Factors Drive the Evolution of Signalling Glands?

Evolutionary Biology, 45(3), 259–267.

By: M. Jara *, A. Frias-De-Diego *, R. García-Roa *, M. Saldarriaga-Córdoba *, L. Harvey *, R. Hickcox *, D. Pincheira-Donoso *

Source: ORCID
Added: April 22, 2024

Employment

Updated: August 24th, 2023 22:22

2022 - present

North Carolina State University Raleigh, US
Postdoctoral Research Scholar Population Health and Pathobiology

2020 - 2022

North Carolina State University Raleigh, North Carolina, US
Ph.D. Population Health and Pathobiology

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