Ana Gracioso Martins

Works (4)

Updated: July 5th, 2023 14:21

2023 journal article

Scalable and High-Throughput In Vitro Vibratory Platform for Vocal Fold Tissue Engineering Applications

BIOENGINEERING-BASEL, 10(5).

By: A. Biehl n, R. Colmon n, A. Timofeeva n , A. Gracioso Martins n, G. Dion *, K. Peters n , D. Freytes n

author keywords: vocal fold; bioreactor; piezoelectric speaker; vibration; frequency; displacement; fibroblasts; mesenchymal stem cells; gene expression
TL;DR: A scalable and high-throughput platform that mimics the mechanical microenvironment of the VFs in vitro and can incorporate commercial assay formats ranging from 6- to 96-well plates which represents a significant improvement in scalability. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 22, 2023

2022 article

Towards a standardized multi-tissue decellularization protocol for the derivation of extracellular matrix materials

Biehl, A., Martins, A. M. G. M., Davis, Z. G. G., Sze, D., Collins, L., Mora-Navarro, C., … Freytes, D. O. O. (2022, December 12). BIOMATERIALS SCIENCE, Vol. 12.

By: A. Biehl  n, A. Martins  n, Z. Davis n , D. Sze n, L. Collins n , C. Mora-Navarro *, M. Fisher n, D. Freytes n

MeSH headings : Tissue Engineering / methods; Proteomics; Extracellular Matrix / chemistry; Hydrogels / chemistry; Biocompatible Materials / analysis; Tissue Scaffolds
TL;DR: The present study is the first proof-of-concept towards the development of a standardized protocol that can be used to derive multiple ECM biomaterials via a previously established automated system and showed gelation and rheological properties consistent with previous ECM hydrogels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023

2021 journal article

Bioreactors for Vocal Fold Tissue Engineering

TISSUE ENGINEERING PART B-REVIEWS, 28(1), 182–205.

By: A. Gracioso Martins n, A. Biehl  n, D. Sze n & D. Freytes n

author keywords: vocal fold; bioreactor; lamina propria; gene expression; fibrosis; inflammation
MeSH headings : Biocompatible Materials; Bioreactors; Cicatrix; Humans; Tissue Engineering / methods; Vocal Cords / pathology; Vocal Cords / physiology
TL;DR: An in-depth analysis of VF bioreactor data to date reveals that mechanical stimulation significantly influences cell viability and the expression of pro-inflammatory and pro-fibrotic genes in vitro. (via Semantic Scholar)
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Source: Web Of Science
Added: March 29, 2021

2021 journal article

Microphysiological System for High-Throughput Computer Vision Measurement of Microtissue Contraction

ACS SENSORS, 6(3), 985–994.

By: A. Martins  n, M. Wilkins n, F. Ligler n, M. Daniele n & D. Freytes n

author keywords: high throughput; 3D culture; tissue function; tissue contraction; computer vision
MeSH headings : Computers; Fibroblasts; High-Throughput Screening Assays; Humans; Image Processing, Computer-Assisted
TL;DR: An inexpensive, versatile, high-throughput platform to measure microtissue contraction in a 96-well plate configuration using one-step batch imaging and an algorithm uses pixel-based image analysis and computer vision techniques for the accurate multiwell quantification of positional changes in the optical microprobes caused by the contraction of the microtissues. (via Semantic Scholar)
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Source: Web Of Science
Added: May 10, 2021

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