Alon Greenbaum
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Works (18)
Updated: April 3rd, 2024 21:48
2024 journal article
Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs
FRONTIERS IN PHARMACOLOGY, 15.
author keywords: intratympanic; inner ear; fluid simulation; round window membrane; pigs; swine; pharmacokinetics
TL;DR:
The potential of using pigs as a large animal model for studying inner ear pharmacokinetic studies of the inner ear using pigs is demonstrated and the diffusion time and drug concentrations reported align closely with the limited data available from human studies.
(via Semantic Scholar)
www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: February 19, 2024
2023 journal article
Assessment of drug permeability through an ex vivo porcine round window membrane model
ISCIENCE, 26(6).
TL;DR:
An ex vivo porcine RWM model, similar in structure and thickness to the human RWM, is developed, which provides a straightforward approach to developing effective and non-invasive delivery methods to the inner ear.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
5. Gender Equality
(Web of Science)
Source: Web Of Science
Added: June 26, 2023
2023 journal article
Bulk and mosaic deletions of Egfr reveal regionally defined gliogenesis in the developing mouse forebrain
ISCIENCE, 26(3).
TL;DR:
Subtractive bulk ventral and dorsal forebrain deletions of Egfr uncovered significant and permanent decreases in oligodendrogenesis and myelination in the cortex and corpus callosum, and a regenerative population of gliogenic progenitors in the mouse forebrain may compensate for the missing EGFR-dependent dorsal glia in the bulk Egfr-deleted forebrain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: June 5, 2023
2023 journal article
COMBINe enables automated detection and classification of neurons and astrocytes in tissue-cleared mouse brains
CELL REPORTS METHODS, 3(4).
MeSH headings : Animals; Mice; Astrocytes; Excipients; Microscopy, Fluorescence; Neurons; Prosencephalon
TL;DR:
An automated workflow to map sparsely labeled neurons and astrocytes in genetically distinct mouse forebrains using mosaic analysis with double markers (MADM) is presented and the regional and subregional effects of MADM-based deletion of the epidermal growth factor receptor (EGFR) are quantitatively analyzed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 30, 2023
2023 journal article
Deep learning-based adaptive optics for light sheet fluorescence microscopy
BIOMEDICAL OPTICS EXPRESS, 14(6), 2905–2919.
TL;DR:
It is shown that the application of correction using a deformable mirror greatly improves image quality and two conceptually different network architectures are compared; one that shares convolutional features and another that estimates each aberration independently.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: July 24, 2023
2023 journal article
Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat
TOXICOLOGICAL SCIENCES, 191(2), 357–373.
author keywords: neurodevelopment; monoamine; OPFR; OPE; flame retardants; neurotransmitters; neurotoxicity; neurotoxicology; prenatal; reproductive and developmental toxicology; mesocortical dopamine system; tissue clearing light sheet microscopy.
TL;DR:
Results indicate maternal exposure to OPFRs alters the development trajectory of the embryonic dopaminergic system and adds to growing evidence of OPFR developmental neurotoxicity.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 12, 2024
2023 journal article
Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models
STAR PROTOCOLS, 4(2).
author keywords: imaged cochleae using open -source software.; several mm; larger animal inner; open -source software
TL;DR:
A protocol that enables three-dimensional (3D) characterization of intact inner ears from large-animal models is presented and a pipeline to count hair cells in antibody-stained and 3D imaged cochleae using open-source software is detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 5, 2023
2022 article
Deep learning-based autofocus method enhances image quality in light-sheet fluorescence microscopy: publishers note (vol 12, pg 5214, 2021)
LI, C., Moatti, A., Zhang, X., Ghashghaei, H. T., & Greenbaum, A. (2022, January 1). BIOMEDICAL OPTICS EXPRESS, Vol. 13, pp. 373–373.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 10, 2022
2022 journal article
Illumination angle correction during image acquisition in light-sheet fluorescence microscopy using deep learning
BIOMEDICAL OPTICS EXPRESS, 13(2), 888–901.
TL;DR:
This study provides a framework that can correct the angle of the light-sheet and improve the overall image quality in high-resolution LSFM 3D image acquisition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 14, 2022
2022 journal article
Inhalable dry powder mRNA vaccines based on extracellular vesicles
Matter, 5(9), 2960–2974.
TL;DR:
The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref
Added: October 17, 2022
2022 journal article
Ontogeny of cellular organization and LGR5 expression in porcine cochlea revealed using tissue clearing and 3D imaging
ISCIENCE, 25(8).
TL;DR:
Data reveal that hair cell organization, inner ear morphology, cellular cartography in the organ of Corti, and spatiotemporal expression of LGR5 are dynamic over developmental stages in a pattern not previously documented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 19, 2022
2022 journal article
Quantitative analysis of illumination and detection corrections in adaptive light sheet fluorescence microscopy
BIOMEDICAL OPTICS EXPRESS, 13(5), 2960–2974.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 31, 2022
2021 journal article
Detection and classification of neurons and glial cells in the MADM mouse brain using RetinaNet
PLOS ONE, 16(9).
MeSH headings : Animals; Brain; Cell Differentiation; Mice; Neuroglia; Neurons
TL;DR:
Object detection networks (neural networks) are utilized to detect and classify targets in complex microscopy images, while simplifying data annotation, and merging the predictions of the two computational models significantly improved the automated cell counting of glial clusters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
8. Decent Work and Economic Growth
(OpenAlex)
Source: Web Of Science
Added: February 28, 2022
2021 article
Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation
Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY, Vol. 9.
author keywords: converse piezoelectric effect; mechanical stimulation; bone regeneration
TL;DR:
The potential of the converse piezoelectric effect to enhance bone regeneration is highlighted by discussing the activation of beneficial cellular pathways, the properties of piezOElectric biomaterials, and the potential for the more effective administration of the Converse pieZoelectrics effect using wireless control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID
Added: September 25, 2021
2021 journal article
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-implanted optical fibers and GRIN lenses
CELL REPORTS, 36(13).
MeSH headings : Animals; Brain / physiology; Head / physiology; Lens, Crystalline / physiology; Lenses; Mice; Neurons / physiology; Optical Fibers; Photons; Refractometry / methods
TL;DR:
A three-dimensional post hoc histology method called “light-guided sectioning” (LiGS), which preserves the tissue with its optical implant in place and allows staining and clearing of a volume up to 500 μm in depth, is developed.
(via Semantic Scholar)
Source: Web Of Science
Added: October 26, 2021
2021 article
Phenotyping Intact Mouse Bones Using Bone CLARITY
SKELETAL DEVELOPMENT AND REPAIR, 2 EDITION, Vol. 2230, pp. 217–230.
author keywords: Tissue Clearing; Bone CLARITY; Three-dimensional imaging; Light-sheet microscopy; Fluorescence microscopy
MeSH headings : Animals; Bone and Bones / diagnostic imaging; Bone and Bones / physiology; Heme / chemistry; Humans; Hydrogels / pharmacology; Imaging, Three-Dimensional / methods; Mice; Optical Imaging / methods; Phenotype; Skull / diagnostic imaging; Skull / physiology; Staining and Labeling / methods
TL;DR:
A bone-clearing methodology, termed Bone CLARITY, which combines published techniques for clearing soft tissues, including delipidation for the removal of light-scattering membranes, hydrogel-embedding for the stabilization of fragile epitopes, and heme elution for the reduction of blood-based autofluorescence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 9, 2021
2020 journal article
Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
NATURE METHODS, 17(5), 541-+.
MeSH headings : Animals; Blood-Brain Barrier / metabolism; Brain / virology; Capsid Proteins / genetics; Capsid Proteins / metabolism; Dependovirus / genetics; Female; Gene Transfer Techniques; Genetic Engineering / methods; Genetic Therapy; Genetic Vectors / genetics; Integrases / metabolism; Male; Mice; Mice, Inbred C57BL; Organ Specificity; Viral Tropism
TL;DR:
M-CREATE is an in vivo screening strategy for identifying recombinant AAVs with desired tropism that can cross the blood–brain barrier in adult mice across strains when delivered intravenously and accelerates the discovery of capsids for use in neuroscience and gene-therapy applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 8, 2020
2020 journal article
Three-dimensional imaging of intact porcine cochlea using tissue clearing and custom-built light-sheet microscopy
BIOMEDICAL OPTICS EXPRESS, 11(11), 6181–6196.
TL;DR:
3D microscopic analysis was performed on an intact cochlea of newborn and juvenile pigs with a volume up to ∼ 250 mm3 using the BoneClear tissue clearing technique, which renders the bone transparent, to support the growing effort to regenerate cochlear tissues and assist with basic research to advance cures for hearing impairments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: December 11, 2020
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