Adrian James Green

Works (14)

Updated: October 16th, 2024 05:02

2024 article

An in vitro and machine learning framework for quantifying serum albumin binding of per- and polyfluoroalkyl substances

Starnes, H. M., Green, A. J., Reif, D. M., & Belcher, S. M. (2024, October 3). TOXICOLOGICAL SCIENCES, Vol. 10.

By: H. Starnes n, A. Green n, D. Reif n  & S. Belcher n 

author keywords: binding affinity; bioaccumulation; computational toxicology; PFAS; protein binding
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 22, 2024

2024 journal article

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

PLOS COMPUTATIONAL BIOLOGY, 20(9).

By: A. Green n, L. Truong *, P. Thunga n , C. Leong*, M. Hancock n, R. Tanguay *, D. Reif n 

Ed(s): S. Scarpino

Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2024

2023 journal article

Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function

NEUROTOXICOLOGY, 96, 129–139.

By: A. Green n, A. Wall n, R. Weeks n, C. Mattingly n , K. Marsden n  & A. Planchart n 

author keywords: Cadmium; Developmental toxicology; Behavior; Vestibular system; P2X receptor; Zebrafish
MeSH headings : Animals; Zebrafish; Cadmium / toxicity; Otolithic Membrane; Vestibule, Labyrinth; Vestibular Diseases
TL;DR: Cadmium-induced ototoxicity is linked to vestibular-based behavioral abnormalities and auditory sensitivity following developmental exposure, and calcium ion channel function is associated with these defects. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2023 journal article

MKX-AS1 Gene Expression Associated with Variation in Drug Response to Oxaliplatin and Clinical Outcomes in Colorectal Cancer Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez *, G. Small*, A. Green n, F. Akhtari *, A. Motsinger-Reif*, J. Quintanilha *, T. Havener *, D. Reif* , H. McLeod *, T. Wiltshire *

author keywords: precision medicine; colorectal cancer; pharmacogenomics; oxaliplatin; lncRNA's; antisense
TL;DR: An association between MKX-AS1 and MKX expression status that could be useful as a prognostic marker of response to OXAL and potential patient outcomes in CRC is suggested. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 19, 2023

2023 journal article

Pharmacogenomic Analyses Implicate B Cell Developmental Status and MKL1 as Determinants of Sensitivity toward Anti-CD20 Monoclonal Antibody Therapy

CELLS, 12(12).

By: G. Small*, F. Akhtari *, A. Green n, T. Havener *, M. Sikes n , J. Quintanhila*, R. Gonzalez *, D. Reif*  ...

author keywords: rituximab (Rituxan (R)); ofatumumab (Arzerra (R),& nbsp;Kesimpta (R)); obinutuzumab (Gazyva (R)); CD20 (MS4A1); MKL1 (MRTFA); TGFB1
TL;DR: Results suggest that the efficacy of anti-CD20 mAb therapy may be influenced by B cell developmental status as well as polymorphism in the MKL1 gene. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 8, 2023

2023 journal article

RYK Gene Expression Associated with Drug Response Variation of Temozolomide and Clinical Outcomes in Glioma Patients

PHARMACEUTICALS, 16(5).

By: R. Gonzalez *, G. Small*, A. Green n, F. Akhtari*, T. Havener *, J. Quintanilha *, A. Cipriani *, D. Reif*  ...

author keywords: GWAS; chemotherapy; sensitivity; resistance; glioma; drug response; temozolomide; knockdown; overexpression; pharmacogenomics; gene expression; RYK
TL;DR: The findings suggest that RYK expression may serve as an important prognostic or predictor of TMZ response and survival for glioma patients and a combination of RyK expression and MGMT status could serve as a additional biomarker for improved survival. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 12, 2023

2023 article

The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Green, A. J., Cox, P. A., … Metcalf, J. S. (2023, August 8). The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish. NEUROTOXICITY RESEARCH, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , A. Green n, P. Cox *, A. Planchart n , J. Metcalf *

author keywords: L-BMAA; D-BMAA; AEG; DAB; ALS; Zebrafish; Neurotoxicity; Neurodegeneration; SOD1
TL;DR: While the results revealed low concentrations of BMAA in the brains of exposed fish, there was no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

The Effects of Long-term, Low-dose beta-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R (Aug, 10.1007/s12640-023-00658-z, 2023)

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 24). NEUROTOXICITY RESEARCH, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , J. Metcalf *, A. Green n, P. Cox *, A. Planchart n 

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Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2022 journal article

LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis

SCIENTIFIC REPORTS, 12(1).

By: K. Polkoff n, N. Gupta  n, A. Green n, Y. Murphy n, J. Chung n, K. Gleason n, S. Simpson*, D. Walker n, B. Collins n, J. Piedrahita n 

MeSH headings : Animals; Animals, Genetically Modified; Biomarkers / metabolism; Hair Follicle / metabolism; Humans; Morphogenesis; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Skin; Stem Cells / metabolism; Swine
TL;DR: It is demonstrated that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development and the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species are reported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022

2021 journal article

Development of a Pandemic Awareness STEM Outreach Curriculum: Utilizing a Computational Thinking Taxonomy Framework

EDUCATION SCIENCES, 11(3).

By: P. Gilchrist n, A. Alexander n, A. Green n, F. Sanders *, A. Hooker* & D. Reif n 

author keywords: science learning; STEM competencies; informal learning; computational thinking; education; curriculum development; data science; teaching; problem solving
TL;DR: This paper documents the theory and design approach used by researchers and practitioners to create a Pandemic Awareness STEM Curriculum and future implications for teaching and learning computational thinking practices through engaging with data science. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 9, 2021

2021 article

Extending the lymphoblastoid cell line model for drug combination pharmacogenomics

Green, A. J., Anchang, B., Akhtari, F. S., Reif, D. M., & Motsinger-Reif, A. (2021, May 28). PHARMACOGENOMICS, Vol. 5.

By: A. Green n, B. Anchang *, F. Akhtari*, D. Reif n  & A. Motsinger-Reif*

author keywords: combination treatment; drug response; LCLs; omics; synergism
MeSH headings : Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor / drug effects; Humans; Lymphocytes / drug effects; Pharmacogenomic Testing / methods
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 29, 2021

2021 journal article

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLOS GENETICS, 17(8).

By: F. Akhtari n, A. Green n, G. Small*, T. Havener *, J. House* , K. Roell  n, D. Reif n , H. McLeod, T. Wiltshire*, A. Motsinger-Reif*

Ed(s): F. Vazquez

MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
TL;DR: The NAD(P)H quinone dehydrogenase 1 (NQO1) gene was found to be associated with the dose-response of arsenic trioxide, erlotinib, tramet inib, and a combination treatment of paclitaxel + epirubicin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 27, 2021

2021 journal article

Leveraging high-throughput screening data, deep neural networks, and conditional generative adversarial networks to advance predictive toxicology

PLOS COMPUTATIONAL BIOLOGY, 17(7).

By: A. Green n, M. Mohlenkamp *, J. Das *, M. Chaudhari *, L. Truong *, R. Tanguay *, D. Reif n 

Ed(s): V. Hatzimanikatis

MeSH headings : Animals; Computational Biology; Embryo, Nonmammalian / drug effects; High-Throughput Screening Assays; Models, Chemical; Neural Networks, Computer; Toxicity Tests; Toxicology; Zebrafish
TL;DR: E embryonic zebrafish were used to examine a suite of morphological and mortality endpoints at six concentrations from over 1,000 unique chemicals found in the ToxCast library, and Go-ZT significantly outperformed the cGAN, support vector machine, random forest and multilayer perceptron models in cross-validation, and when tested against an external test dataset. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 5, 2021

2017 journal article

The neurological toxicity of heavy metals: A fish perspective

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 208, 12–19.

By: A. Green n & A. Planchart n 

Contributors: A. Green n & A. Planchart n 

MeSH headings : Animals; Animals, Genetically Modified; Behavior, Animal / drug effects; Disease Models, Animal; Gene Expression Regulation, Developmental / drug effects; Heavy Metal Poisoning, Nervous System / etiology; Heavy Metal Poisoning, Nervous System / genetics; Heavy Metal Poisoning, Nervous System / metabolism; Heavy Metal Poisoning, Nervous System / pathology; Humans; Metals, Heavy / toxicity; Nerve Degeneration; Nervous System / drug effects; Nervous System / metabolism; Nervous System / pathology; Nervous System / physiopathology; Neurons / drug effects; Neurons / metabolism; Neurons / pathology; Risk Assessment; Water Pollutants, Chemical / toxicity; Zebrafish / genetics; Zebrafish / metabolism
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

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