Alix Kay Berglund

Works (13)

Updated: April 24th, 2025 07:27

2024 journal article

IL-1β + TGF-β2 dual-licensed mesenchymal stem cells have reduced major histocompatibility class I expression and positively modulate tenocyte migration, metabolism, and gene expression

Journal of the American Veterinary Medical Association, 262(S1), S61–S72.

By: D. Koch n, A. Froneberger n, A. Berglund n, S. Connard n, A. Souther n & L. Schnabel n 

author keywords: mesenchymal stem cell; tendon; MHC class I; IL-1 beta; TGF-beta 2
MeSH headings : Animals; Mesenchymal Stem Cells / metabolism; Horses; Interleukin-1beta / metabolism; Interleukin-1beta / genetics; Transforming Growth Factor beta2 / metabolism; Transforming Growth Factor beta2 / genetics; Tenocytes / metabolism; Cell Movement / drug effects; Gene Expression Regulation / drug effects; Histocompatibility Antigens Class I / metabolism; Histocompatibility Antigens Class I / genetics; Cells, Cultured
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Burn Injury Management and Outcomes
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 22, 2024

2023 article

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β 2 -integrin activation and signaling

Conley, H., Till, R. L., Berglund, A. K., Jones, S. L., & Sheats, M. K. (2023, July 13). Cell Adhesion & Migration, Vol. 17, pp. 1–16.

By: H. Conley n, R. Till n, A. Berglund n, S. Jones n  & M. Sheats n 

author keywords: Beta2-integrin; ICAM-1; MARCKS; neutrophils; outside-in; >
MeSH headings : Alanine; CD18 Antigens / metabolism; Neutrophils; Peptides / pharmacology; Signal Transduction; Myristoylated Alanine-Rich C Kinase Substrate / antagonists & inhibitors
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Cell Adhesion Molecules Research; Protease and Inhibitor Mechanisms
TL;DR: MANS treatment significantly attenuated ICAM-1/Mn2+-stimulated static adhesion, cell spreading andβ2-integrin clustering, suggesting a role for MARCKS function in outside-in β2-Integrin activation. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 13, 2023

2023 journal article

Effect of gentamicin on CD3+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study

Veterinary Ophthalmology, 26(4), 347–354.

By: H. Smith  n, A. Berglund n, J. Robertson n , L. Schnabel n , R. McMullen *, B. Gilger n , A. Oh n 

author keywords: autoimmune disease; equine recurrent uveitis; gentamicin; horse; immunology; intravitreal injection
topics (OpenAlex): Ocular Infections and Treatments; Mycobacterium research and diagnosis
TL;DR: Gentamicin had no effect on equine peripheral blood CD3+ T-lymphocyte cell viability and proliferation in concentrations ranging from "safe" to "retinotoxic" in relation to intravitreal injection volumes. (via Semantic Scholar)
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Added: April 29, 2023

2022 journal article

Interleukin-1β in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

Frontiers in Veterinary Science, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n 

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Diabetic Foot Ulcer Assessment and Management
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: December 12, 2022

2022 journal article

TGF-β2 enhances expression of equine bone marrow-derived mesenchymal stem cell paracrine factors with known associations to tendon healing

Stem Cell Research & Therapy, 13(1).

By: D. Koch n, L. Schnabel n , I. Ellis n, R. Bates n & A. Berglund n

author keywords: Mesenchymal stem cell; Tenocyte; TGF-beta 2; Equine; Tendon; RNA-sequencing; Paracrine factors; Extracellular matrix
MeSH headings : Animals; Bone Marrow / metabolism; Collagen Type I / metabolism; Cytokines / metabolism; Horses; Mesenchymal Stem Cells / metabolism; Paracrine Communication; RNA / metabolism; Tenascin / genetics; Tenascin / metabolism; Tendons / metabolism; Transforming Growth Factor beta2 / genetics; Transforming Growth Factors / metabolism
topics (OpenAlex): Tendon Structure and Treatment; Wound Healing and Treatments; Periodontal Regeneration and Treatments
TL;DR: Treating equine BM-MSCs with TGF-β2 significantly increases production of paracrine factors and extracellular matrix molecules important for tendon healing and promotes the migration of tenocytes in vitro. (via Semantic Scholar)
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Added: September 26, 2022

2021 article

Adeno-Associated Virus-Mediated Overexpression of Interleukin-10 Affects the Immunomodulatory Properties of Equine Bone Marrow-Derived Mesenchymal Stem Cells

Cameron, A. D., Even, K. M., Linardi, R. L., Berglund, A. K., Schnabel, L. V., Engiles, J. B., & Ortved, K. F. (2021, April 12). Human Gene Therapy, Vol. 32, pp. 907–918.

By: A. Cameron*, K. Even *, R. Linardi *, A. Berglund n, L. Schnabel n , J. Engiles *, K. Ortved *

author keywords: osteoarthritis; PTOA; immunomodulation; mesenchymal stem cell; IL-10; AAV
MeSH headings : Animals; Bone Marrow; Cells, Cultured; Dependovirus / genetics; Horses; Interleukin-10 / genetics; Mesenchymal Stem Cells
topics (OpenAlex): Mesenchymal stem cell research; Osteoarthritis Treatment and Mechanisms; Diabetic Foot Ulcer Assessment and Management
TL;DR: It is hypothesized that BM-MSCs overexpressing IL-10 would have superior immunomodulatory effects leading to increased suppression of T-cell proliferation and decreased production of pro-inflammatory cytokines providing protection of the extra-cellular matrix (ECM) in a stimulated, co-culture OA model. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 24, 2021

2021 article

Corrigendum to “Effects of continuous passage on the immunomodulator properties of equine bone marrow-derived mesenchymal stem cells in vitro” [Vet. Immunol. Immunopathol. 234 (2021) 110203]

Connard, S. S., Linardi, R. L., Even, K. M., Berglund, A. K., Schnabel, L. V., & Ortved, K. F. (2021, October 28). Veterinary Immunology and Immunopathology, Vol. 242.

By: S. Connard *, R. Linardi *, K. Even *, A. Berglund n, L. Schnabel n  & K. Ortved *

topics (OpenAlex): Mesenchymal stem cell research
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Added: March 7, 2022

2021 journal article

Effects of continuous passage on the immunomodulatory properties of equine bone marrow-derived mesenchymal stem cells in vitro

Veterinary Immunology and Immunopathology, 234, 110203.

By: S. Connard *, R. Linardi *, K. Even *, A. Berglund n, L. Schnabel n  & K. Ortved *

author keywords: Horse; Mesenchymal stem cells; Continuous passage; Immunomodulation
MeSH headings : Animals; Bone Marrow Cells / drug effects; Bone Marrow Cells / immunology; Bone Marrow Cells / physiology; Cell Differentiation / drug effects; Cell Differentiation / immunology; Cell Proliferation / drug effects; Cells, Cultured; Cytokines / analysis; Cytokines / biosynthesis; Cytokines / immunology; Female; Horses; Immunomodulation; In Vitro Techniques; Interferon-gamma / pharmacology; Lymphocyte Activation / drug effects; Lymphocyte Activation / immunology; Male; Mesenchymal Stem Cells / immunology; Mesenchymal Stem Cells / physiology
topics (OpenAlex): Mesenchymal stem cell research; Wound Healing and Treatments; Tissue Engineering and Regenerative Medicine
TL;DR: It is demonstrated that culture expansion affects some of the immunomodulatory properties of BM-MSCs in vitro, which may suggest that MSCs isolated from a single collection of bone marrow may be culture expanded, but only those from lower passage numbers would be ideal for clinical application. (via Semantic Scholar)
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Added: October 12, 2021

2021 journal article

TGF-β2 Reduces the Cell-Mediated Immunogenicity of Equine MHC-Mismatched Bone Marrow-Derived Mesenchymal Stem Cells Without Altering Immunomodulatory Properties

Frontiers in Cell and Developmental Biology, 9.

By: A. Berglund n, J. Long n, J. Robertson n  & L. Schnabel n 

author keywords: mesenchymal stem cell; TGF-β 2; cytotoxicity; immunogenicity; major histocompatibility complex; allogeneic
topics (OpenAlex): Mesenchymal stem cell research; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: It is indicated that treating MSCs with TGF-β2 is a promising strategy to reduce the cell-mediated immunogenicity of MHC-mismatched M SCs and facilitate allogeneic MSC therapy. (via Semantic Scholar)
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Added: March 8, 2021

2020 article

Cross-matching of allogeneic mesenchymal stromal cells eliminates recipient immune targeting

Rowland, A. L., Miller, D., Berglund, A., Schnabel, L. V., Levine, G. J., Antczak, D. F., & Watts, A. E. (2020, December 25). Stem Cells Translational Medicine, Vol. 10, pp. 694–710.

By: A. Rowland*, D. Miller *, A. Berglund n, L. Schnabel n , G. Levine*, D. Antczak *, A. Watts *

author keywords: allogeneic; alloimmunization; antibody; autologous; cross‐ match; humoral; innate; intra‐ articular; major histocompatibility complex (MHC); MSC
MeSH headings : Adaptive Immunity; Allografts; Animals; Chemokine CXCL12; Histocompatibility Testing / veterinary; Horses; Immunity, Innate; Major Histocompatibility Complex; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Synovial Fluid / immunology; Transplantation, Autologous
topics (OpenAlex): Mesenchymal stem cell research; IL-33, ST2, and ILC Pathways; Periodontal Regeneration and Treatments
TL;DR: Until immune recognition of MSCs can be avoided, repeated clinical use of M SCs should be limited to autologous or cross‐matched allogeneic MSC s, and presensitization against donor MHC should be assessed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021

2018 article

Pooled Platelet-Rich Plasma Lysate Therapy Increases Synoviocyte Proliferation and Hyaluronic Acid Production While Protecting Chondrocytes From Synoviocyte-Derived Inflammatory Mediators

Gilbertie, J. M., Long, J. M., Schubert, A. G., Berglund, A. K., Schaer, T. P., & Schnabel, L. V. (2018, July 4). Frontiers in Veterinary Science, Vol. 5.

By: J. Gilbertie  n, J. Long n, A. Schubert n, A. Berglund n, T. Schaer * & L. Schnabel n 

author keywords: platelet-rich plasma lysate; osteoarthritis; IL-1 beta; LPS; HA; collagen type II; aggrecan; MMP-13
topics (OpenAlex): Periodontal Regeneration and Treatments; Tendon Structure and Treatment; Osteoarthritis Treatment and Mechanisms
TL;DR: The results of this study support continued investigation into the use of pooled PRP-L for the treatment of osteoarthritis and warrant further in-vitro studies to discern the mechanisms of action of PRp-L. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: December 17, 2018

2017 journal article

Effect of bone marrow-derived mesenchymal stem cells and stem cell supernatant on equine corneal wound healing in vitro

Stem Cell Research & Therapy, 8(1).

By: A. Sherman n, B. Gilger n , A. Berglund n & L. Schnabel n 

author keywords: Mesenchymal stem cells; Equine; Corneal wound healing; Corneal stromal cells/fibroblasts; Scratch assay; TGF-beta 1
MeSH headings : Animals; Biomarkers / metabolism; Bone Marrow Cells / cytology; Corneal Injuries / pathology; Corneal Injuries / therapy; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / metabolism; Female; Flow Cytometry; Horses; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Transforming Growth Factor beta1 / metabolism; Wound Healing
topics (OpenAlex): Mesenchymal stem cell research; Corneal Surgery and Treatments; Periodontal Regeneration and Treatments
TL;DR: The significant decrease in scratch area in equine corneal fibroblast cultures treated with autologous BM-MSCs compared to MSC-Sp or control treatments suggests that BM- MSCs may substantially improve corNEal wound healing in horses. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 article

Allogeneic major histocompatibility complex‐mismatched equine bone marrow‐derived mesenchymal stem cells are targeted for death by cytotoxic anti‐major histocompatibility complex antibodies

Berglund, A. K., & Schnabel, L. V. (2016, November 14). Equine Veterinary Journal, Vol. 49, pp. 539–544.

By: A. Berglund n & L. Schnabel n 

author keywords: horse; mesenchymal stem cell; allogeneic; major histocompatibility complex-mismatched; antibody response; complement-dependent cytotoxicity
MeSH headings : Animals; Antibodies / immunology; Antibody Formation / immunology; Bone Marrow; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Horses; Major Histocompatibility Complex / immunology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / immunology
topics (OpenAlex): Mesenchymal stem cell research; Xenotransplantation and immune response; Tissue Engineering and Regenerative Medicine
TL;DR: The cytotoxic antibody response induced in recipient horses following injection with donor MHC‐mismatched MSCs is capable of killing donor MSCS in vitro. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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