Anuran Kumar Gayen

College of Sciences

Works (5)

Updated: July 5th, 2023 15:31

2020 journal article

An artificial pathway for polyketide biosynthesis

Nature Catalysis, 3(7), 536–538.

By: A. Gayen n, L. Nichols n & G. Williams n 

TL;DR: Some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions. (via Semantic Scholar)
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Added: August 3, 2020

2020 article

Synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis of isoprenoids (September, 10.1007/s10295-020-02306-3, 2020)

Malico, A. A., Calzini, M. A., Gayen, A. K., & Williams, G. J. (2020, December). JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, Vol. 47, pp. 1181–1181.

By: A. Malico n, M. Calzini n, A. Gayen n & G. Williams n 

TL;DR: The article title was published incorrectly in the HTML version (online version only) of the online published article. (via Semantic Scholar)
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Added: November 30, 2020

2020 journal article

Synthetic biology, combinatorial biosynthesis, and chemo‑enzymatic synthesis of isoprenoids

Journal of Industrial Microbiology & Biotechnology, 47(9-10), 675–702.

By: A. Malico n, M. Calzini n, A. Gayen n & G. Williams n 

author keywords: Isoprenoids; Terpenes; Synthetic biology; Combinatorial biosynthesis; Hemiterpenes
MeSH headings : Biological Products; Hemiterpenes; Synthetic Biology; Terpenes / chemistry
TL;DR: This review summarizes recent advances and strategies related to isoprenoid synthetic biology, combinatorial biosynthesis, and chemo-enzymatic synthesis, focusing on the past 5 years, as well as emerging applications of cell-free biosynthesis and high-throughput tools. (via Semantic Scholar)
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Added: September 21, 2020

2019 journal article

Development of a Genetically Encoded Biosensor for Detection of Polyketide Synthase Extender Units in Escherichia coli

ACS Synthetic Biology, 8(6), 1391–1400.

By: E. Kalkreuter  n, A. Keeler  n, A. Malico n, K. Bingham n, A. Gayen n & G. Williams n 

MeSH headings : Biosensing Techniques / methods; Escherichia coli / genetics; Escherichia coli Proteins / genetics; Escherichia coli Proteins / isolation & purification; Escherichia coli Proteins / metabolism; Malonyl Coenzyme A / analysis; Malonyl Coenzyme A / metabolism; Metabolic Networks and Pathways; Polyketide Synthases / metabolism; Polyketides / metabolism; Protein Engineering / methods; Recombinant Proteins / genetics; Recombinant Proteins / isolation & purification; Recombinant Proteins / metabolism; Synthetic Biology; Transcription Factors / genetics; Transcription Factors / isolation & purification; Transcription Factors / metabolism
TL;DR: The previously unknown broad effector promiscuity of FapR provides a platform to develop new tools and approaches that can be leveraged to overcome limitations of pathways that construct diverse α-carboxyacyl-CoAs and those that are dependent on them, including biofuels, antibiotics, anticancer drugs, and other value-added products. (via Semantic Scholar)
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Added: July 15, 2019

2019 journal article

Synthesis and anticancer activities of proline-containing cyclic peptides and their linear analogs and congeners

SYNTHETIC COMMUNICATIONS, 49(2), 221–236.

By: K. Ghosh*, I. Duttagupta *, C. Bose*, P. Banerjee*, A. Gayen n & S. Sinha *

author keywords: Anticancer activities; cell migration efficiency; cyclic peptides; linear peptides; Reniochalistatin
TL;DR: A solution phase method was adopted for the synthesis of proline-containing cyclic pentapeptides 2 and total synthesis of naturally occurring cyclic heptapeptide Reniochalistatin B 3 and their linear analogs/congeners were evaluated for anti-cancer activity against HeLa cell line. (via Semantic Scholar)
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Source: Web Of Science
Added: February 18, 2019

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