Works (37)

Updated: February 16th, 2024 05:00

2024 journal article

Myeloid cell MHC I expression drives CD8+ T cell activation in nonalcoholic steatohepatitis

FRONTIERS IN IMMUNOLOGY, 14.

By: V. Adams n, L. Collins n, T. Williams n, J. Holmes n, P. Hess n, H. Atkins n, G. Scheidemantle n, X. Liu n ...

co-author countries: United States of America 🇺🇸

Contributors: T. Williams n, V. Adams n, L. Collins n, J. Holmes n, P. Hess n, H. Atkins n, G. Scheidemantle n, X. Liu n ...

Ed(s): T. Williams n, L. Collins n & A. Kennedy n

author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
Sources: Web Of Science, ORCID
Added: January 28, 2024

2022 journal article

Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1867(1).

By: A. Pal*, S. Sun*, M. Armstrong*, J. Manke*, N. Reisdorph*, V. Adams n, A. Kennedy n, Y. Zu* ...

co-author countries: United States of America 🇺🇸
author keywords: N-3 polyunsaturated fatty acids; bacteria; Microbial; Lipidomics
MeSH headings : Akkermansia / genetics; Akkermansia / growth & development; Animals; Cardiometabolic Risk Factors; Cell Differentiation / drug effects; Diet, High-Fat / adverse effects; Eicosapentaenoic Acid / metabolism; Eicosapentaenoic Acid / pharmacology; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Glucose / metabolism; Humans; Hydroxyeicosatetraenoic Acids / biosynthesis; Hydroxyeicosatetraenoic Acids / blood; Male; Mass Spectrometry; Mice; Mice, Obese / genetics; Mice, Obese / microbiology; Phosphatidylinositol 3-Kinases / genetics; Proto-Oncogene Proteins c-akt / genetics; RNA, Ribosomal, 16S / genetics; Sex Characteristics; Th17 Cells / metabolism; Triglycerides / blood
Sources: Web Of Science, ORCID
Added: November 8, 2021

2022 journal article

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis

METABOLOMICS, 18(8).

By: L. Duan n, G. Scheidemantle n, M. Lodge n, M. Cummings n, E. Pham n, X. Wang n, A. Kennedy n, X. Liu n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
Sources: Web Of Science, ORCID
Added: July 26, 2022

2020 journal article

CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease

American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(2), G211–G224.

By: D. Breuer n, M. Pacheco*, M. Washington*, S. Montgomery*, A. Hasty* & A. Kennedy n

co-author countries: United States of America 🇺🇸
author keywords: CD8(+) T cells; lymphocytes; nonalcoholic steatohepatitis; stellate cells
MeSH headings : Animals; CD8-Positive T-Lymphocytes / pathology; Hepatic Stellate Cells / drug effects; Hepatitis / pathology; Humans; Hyperlipidemias / pathology; Interleukin-10 / biosynthesis; Liver / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease / complications; Non-alcoholic Fatty Liver Disease / pathology; Obesity / etiology; Obesity / pathology; Receptors, LDL / genetics; Receptors, LDL / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2020 journal article

Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health

DIABETES, 69(3), 342–354.

By: X. Tong*, C. Dai*, J. Walker*, G. Nair*, A. Kennedy n, R. Carr*, M. Hebrok*, A. Powers*, R. Stein*

co-author countries: United States of America 🇺🇸
MeSH headings : Acinar Cells / pathology; Acinar Cells / ultrastructure; Adolescent; Adult; Age Factors; Aged; Animals; Child; Child, Preschool; Diabetes Mellitus, Experimental / pathology; Diabetes Mellitus, Type 2 / pathology; Embryonic Stem Cells; Female; Glucagon-Secreting Cells / pathology; Glucagon-Secreting Cells / ultrastructure; Humans; Infant; Insulin-Secreting Cells / pathology; Insulin-Secreting Cells / ultrastructure; Islets of Langerhans / cytology; Islets of Langerhans / pathology; Islets of Langerhans / ultrastructure; Islets of Langerhans Transplantation; Lipid Droplets / pathology; Lipid Droplets / ultrastructure; Male; Mice; Microscopy, Electron; Microscopy, Fluorescence; Middle Aged; Rats; Tissue Donors; Young Adult
Sources: Web Of Science, ORCID
Added: March 16, 2020

2018 journal article

Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons

JAIDS Journal of Acquired Immune Deficiency Syndromes, 77(2), e14–e21.

By: J. Koethe*, W. McDonnell*, A. Kennedy*, C. Abana*, M. Pilkinton*, I. Setliff*, I. Georgiev*, L. Barnett* ...

co-author countries: United States of America 🇺🇸
author keywords: HIV; obesity; metabolic disease; adipose tissue; T-cell receptor; clonality
MeSH headings : Adipose Tissue / pathology; Adult; Anti-HIV Agents / therapeutic use; Blood Cells; CD8-Positive T-Lymphocytes / chemistry; CD8-Positive T-Lymphocytes / immunology; Cohort Studies; Female; HIV Infections / drug therapy; HIV Infections / pathology; Humans; Male; Middle Aged; Receptors, Antigen, T-Cell / analysis; Sequence Analysis, DNA; Sustained Virologic Response; T-Lymphocyte Subsets / chemistry; T-Lymphocyte Subsets / immunology
Sources: Crossref, ORCID
Added: January 20, 2020

2018 journal article

Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments

Molecular Metabolism, 8, 86–95.

By: W. Bolus*, K. Peterson*, M. Hubler*, A. Kennedy*, M. Gruen* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: Inflammation; Obesity; Diabetes; Eosinophils; Interleukin 5; Adipose tissue
MeSH headings : Adipose Tissue / drug effects; Adipose Tissue / pathology; Animals; Energy Metabolism; Eosinophils / drug effects; Insulin / metabolism; Interleukin-5 / pharmacology; Interleukin-5 / therapeutic use; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Obesity / pathology
Sources: Web Of Science, ORCID
Added: November 22, 2020

2018 journal article

High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity

Diabetes, 67(11), 2361–2376.

co-author countries: Australia 🇦🇺 United States of America 🇺🇸
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Animals; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Complementarity Determining Regions / metabolism; Diet, High-Fat; Glucose Tolerance Test; Insulin Resistance; Liver / immunology; Liver / metabolism; Male; Mice; Obesity / immunology; Obesity / metabolism; Prostaglandins / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2018 journal article

MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice

American Journal of Physiology-Cell Physiology, 315(3), C319–C329.

By: M. Hubler*, K. Erikson*, A. Kennedy* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: adipose; homeostasis; iron; macrophage; polarization
MeSH headings : Adipocytes / metabolism; Adipocytes / physiology; Adipose Tissue / metabolism; Adipose Tissue / physiology; Animals; Cell Line; Dietary Supplements; Inflammation / metabolism; Inflammation / physiopathology; Iron Overload / metabolism; Iron Overload / physiopathology; Iron, Dietary / metabolism; Macrophages / metabolism; Macrophages / physiology; Male; Mice; Mice, Inbred C57BL; Monocytes / metabolism; Monocytes / physiology
Sources: Crossref, ORCID
Added: January 20, 2020

2018 journal article

Macrophage-Targeted Therapeutics for Metabolic Disease

Trends Pharmacological Sciences, 39, 536–546.

By: K. Peterson*, M. Cottam*, A. Kennedy* & A. Hasty*

co-author countries: United States of America 🇺🇸
MeSH headings : Drug Delivery Systems / methods; Gene Expression / drug effects; Humans; Macrophages / drug effects; Macrophages / immunology; Metabolic Diseases / drug therapy; Metabolic Diseases / immunology; Molecular Targeted Therapy; Pharmaceutical Preparations / administration & dosage
Sources: Web Of Science, ORCID
Added: January 20, 2020

2018 journal article

Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention

Physiological Reports, 6(22), e13919.

By: W. Bolus*, A. Kennedy* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: Adipose tissue; eosinophils; inflammation; macrophages; obesity; weight loss
MeSH headings : Adipose Tissue / pathology; Animals; Caloric Restriction; Cells, Cultured; Eosinophils / pathology; Male; Mice; Mice, Inbred C57BL; Obesity / diet therapy; Obesity / pathology; Weight Loss
Sources: Crossref, ORCID
Added: January 20, 2020

2016 journal article

CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice

Physiological Reports, 4(18), e12971.

By: J. Orr*, A. Kennedy*, A. Hill*, E. Anderson-Baucum*, M. Hubler* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: Adipose tissue; CCR7; macrophages; obesity; T cells
MeSH headings : Adipose Tissue / metabolism; Adipose Tissue / pathology; Animals; CD8-Positive T-Lymphocytes / metabolism; Diet, High-Fat / adverse effects; Fatty Liver / etiology; Fatty Liver / metabolism; Fatty Liver / pathology; Interleukins / metabolism; Macrophage Activation; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Obesity / etiology; Obesity / metabolism; Obesity / pathology; Receptors, CCR7 / genetics; Receptors, CCR7 / metabolism; Tumor Necrosis Factor-alpha / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2016 journal article

Role of lipids in the metabolism and activation of immune cells

The Journal of Nutritional Biochemistry, 34, 1–7.

By: M. Hubler* & A. Kennedy*

co-author countries: United States of America 🇺🇸
author keywords: Inflammation; Macrophages; T lymphocytes; Oxysterols; Fatty acids
Sources: Crossref, ORCID
Added: January 20, 2020

2015 journal article

Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment

Molecular Metabolism, 4(10), 665–677.

By: A. Hill*, E. Anderson-Baucum*, A. Kennedy*, C. Webb*, F. Yull* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: Adipose tissue; Macrophage; Apoptosis; Cleaved caspase-3; NF-kappa B; Survival
Sources: Crossref, ORCID
Added: January 20, 2020

2015 journal article

CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue

Journal of Leukocyte Biology, 98(4), 467–477.

By: W. Bolus*, D. Gutierrez*, A. Kennedy*, E. Anderson-Baucum* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: inflammation; obesity; interleukin 5
MeSH headings : Adipose Tissue / immunology; Animals; Cell Separation; Eosinophils / immunology; Flow Cytometry; Immunohistochemistry; Inflammation / immunology; Insulin Resistance / immunology; Interleukin-13 / biosynthesis; Interleukin-4 / biosynthesis; Interleukin-5 / biosynthesis; Macrophage Activation / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity / immunology; Real-Time Polymerase Chain Reaction; Receptors, CCR2 / immunology
Sources: Crossref, ORCID
Added: January 20, 2020

2013 journal article

Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance

Diabetes, 62(6), 1888–1896.

By: L. Kang*, L. Lantier*, A. Kennedy*, J. Bonner*, W. Mayes*, D. Bracy*, L. Bookbinder*, A. Hasty*, C. Thompson*, D. Wasserman*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Adhesion Molecules / therapeutic use; Diet, High-Fat / adverse effects; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / therapeutic use; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Insulin Resistance / physiology; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Obesity / drug therapy; Obesity / etiology; Obesity / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2013 journal article

Isolation of Adipose Tissue Immune Cells

Journal of Visualized Experiments, 5(75).

By: J. Orr*, A. Kennedy* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: Immunology; Issue 75; Cellular Biology; Molecular Biology; Biophysics; Physiology; Anatomy; Biomedical Engineering; Surgery; Metabolic Diseases; Diabetes Mellitus; diabetes; Endocrine System Diseases; adipose tissue; AT; stromal vascular fraction; macrophage; lymphocyte; T cells; adipocyte; inflammation; obesity; cell; isolation; FACS; flow cytometry; mice; animal model
Sources: Crossref, ORCID
Added: January 20, 2020

2013 journal article

Loss of CCR5 results in glucose intolerance in diet-induced obese mice

American Journal of Physiology-Endocrinology and Metabolism, 305(7), E897–E906.

By: A. Kennedy*, C. Webb*, A. Hill*, M. Gruen*, L. Jackson* & A. Hasty*

co-author countries: United States of America 🇺🇸
author keywords: C-C chemokine receptor 5; diet-induced obesity; macrophages; T cells; inflammation; insulin resistance; adipose tissue
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Animals; Glucose / metabolism; Glucose Intolerance / genetics; Glucose Intolerance / immunology; Glucose Intolerance / metabolism; Inflammation / genetics; Inflammation / immunology; Inflammation / metabolism; Insulin / metabolism; Insulin Resistance / immunology; Insulin Resistance / physiology; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Knockout; Mice, Obese; Muscle, Skeletal / immunology; Muscle, Skeletal / metabolism; Receptors, CCR5 / genetics; Receptors, CCR5 / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2013 journal article

Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution

Diabetes, 63(2), 421–432.

By: J. Orr*, A. Kennedy*, E. Anderson-Baucum*, C. Webb*, S. Fordahl*, K. Erikson*, Y. Zhang*, A. Etzerodt*, S. Moestrup*, A. Hasty*

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
MeSH headings : Adipose Tissue / cytology; Animals; Dietary Fats / adverse effects; Gene Expression Regulation; Iron / metabolism; Macrophages / chemistry; Macrophages / metabolism; Male; Mice; Obesity / chemically induced; Tissue Distribution
Sources: Crossref, ORCID
Added: January 20, 2020

2013 journal article

Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance

Diabetes, 62(9), 3180–3188.

By: E. Anderson*, D. Gutierrez*, A. Kennedy* & A. Hasty*

co-author countries: United States of America 🇺🇸
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Animals; Blotting, Western; Body Composition / physiology; Body Weight / physiology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / metabolism; Flow Cytometry; Glucose Tolerance Test; Insulin Resistance / physiology; Male; Mice; Mice, Inbred C57BL; Obesity / metabolism; Obesity / physiopathology; Reverse Transcriptase Polymerase Chain Reaction
Sources: Crossref, ORCID
Added: January 20, 2020

2012 journal article

Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes

Journal of Lipid Research, 54(3), 662–670.

By: K. Martinez*, S. Shyamasundar*, A. Kennedy*, C. Chuang*, A. Marsh*, J. Kincaid*, T. Reid*, M. McIntosh*

co-author countries: United States of America 🇺🇸
author keywords: interleukins; intracellular calcium; lipogenic genes; delipidation
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Calcium / metabolism; Cells, Cultured; Chemokine CCL2 / metabolism; Diacylglycerol Kinase / antagonists & inhibitors; Diacylglycerol Kinase / genetics; Diacylglycerol Kinase / metabolism; Enzyme Inhibitors; Humans; Inflammation / chemically induced; Inflammation / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Linoleic Acids, Conjugated / pharmacology; Pyrimidinones / pharmacology; Thiazoles / pharmacology
Sources: Crossref, ORCID
Added: January 20, 2020

2012 journal article

Impact of Macrophage Inflammatory Protein-1α Deficiency on Atherosclerotic Lesion Formation, Hepatic Steatosis, and Adipose Tissue Expansion

PLoS One, 7(2), e31508.

By: A. Kennedy*, M. Gruen*, D. Gutierrez*, B. Surmi*, J. Orr*, C. Webb*, A. Hasty*

co-author countries: United States of America 🇺🇸
MeSH headings : Adipose Tissue / pathology; Animals; Atherosclerosis / etiology; Atherosclerosis / pathology; Body Weight; Bone Marrow Transplantation; Chemokine CCL3 / deficiency; Chemokine CCL3 / physiology; Diet; Fatty Liver / etiology; Female; Hyperlipidemias; Lipid Metabolism; Lipids / blood; Male; Mice; Mice, Knockout
Sources: Web Of Science, ORCID
Added: November 22, 2020

2011 journal article

Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity

Diabetes, 60(11), 2820–2829.

By: D. Gutierrez*, A. Kennedy*, J. Orr*, E. Anderson*, C. Webb*, W. Gerrald*, A. Hasty*

co-author countries: United States of America 🇺🇸
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Adipose Tissue / pathology; Animals; Antigens, Differentiation / metabolism; Dietary Fats / adverse effects; Disease Progression; Glucose Intolerance / etiology; Glucose Intolerance / immunology; Glucose Intolerance / metabolism; Glucose Intolerance / pathology; Glucose Tolerance Test; Insulin Resistance; Interferon-gamma / metabolism; Interleukin-4 / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells / immunology; Myeloid Cells / metabolism; Myeloid Cells / pathology; Obesity / immunology; Obesity / metabolism; Obesity / pathology; Obesity / physiopathology; Organ Specificity; Receptors, CCR2 / genetics; Receptors, CCR2 / physiology; Time Factors
Sources: Crossref, ORCID
Added: January 20, 2020

2011 journal article

Grape powder extract attenuates tumor necrosis factor α-mediated inflammation and insulin resistance in primary cultures of human adipocytes

The Journal of Nutritional Biochemistry, 22(1), 89–94.

By: C. Chuang*, A. Bumrungpert*, A. Kennedy*, A. Overman*, T. West*, B. Dawson*, M. McIntosh*

co-author countries: Thailand 🇹🇭 United States of America 🇺🇸
author keywords: Grapes; Grape powder extract; Adipocytes; Inflammation; Insulin resistance
MeSH headings : Abdominal Fat / cytology; Abdominal Fat / drug effects; Abdominal Fat / metabolism; Adult; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Anti-Obesity Agents / pharmacology; Cells, Cultured; Female; Fruit / chemistry; Gene Expression Regulation / drug effects; Humans; Inflammation Mediators / metabolism; Insulin Receptor Substrate Proteins / metabolism; Insulin Resistance; Middle Aged; Phosphorylation / drug effects; Phytotherapy; Plant Extracts / pharmacology; Protein Tyrosine Phosphatase, Non-Receptor Type 1 / genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism; RNA, Messenger / metabolism; Signal Transduction / drug effects; Tumor Necrosis Factor-alpha / metabolism; Vitis / chemistry; Young Adult
Sources: Crossref, ORCID
Added: January 20, 2020

2011 journal article

JNK Inhibition by SP600125 Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Regulation of Inflammatory and Lipogenic Gene Expression

Lipids, 46(10), 885–892.

By: K. Martinez*, A. Kennedy* & M. McIntosh*

co-author countries: United States of America 🇺🇸
author keywords: Conjugated linoleic acid; Adipocytes; JNK; cJun; Inflammation; Lipogenic genes
MeSH headings : Activating Transcription Factor 3 / immunology; Adipocytes / drug effects; Adipocytes / immunology; Adult; Anthracenes / pharmacology; Cells, Cultured; Female; Gene Expression Regulation / drug effects; Humans; Inflammation / drug therapy; Insulin Resistance; JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors; Linoleic Acids, Conjugated / immunology; Lipogenesis / drug effects; Middle Aged; Signal Transduction / drug effects; Young Adult
Sources: Crossref, ORCID
Added: January 20, 2020

2010 journal article

Antiobesity mechanisms of action of conjugated linoleic acid

The Journal of Nutritional Biochemistry, 21(3), 171–179.

By: A. Kennedy*, K. Martinez*, S. Schmidt*, S. Mandrup*, K. LaPoint* & M. McIntosh*

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
author keywords: CIA; Obesity; Adipose tissue; Energy metabolism; PPAR gamma; Adipogenesis; Inflammation
MeSH headings : Adipogenesis; Adiposity; Animals; Apoptosis; Body Weight; Dietary Fats, Unsaturated / administration & dosage; Dietary Fats, Unsaturated / metabolism; Dietary Supplements; Energy Metabolism; Humans; Inflammation; Linoleic Acids, Conjugated / administration & dosage; Linoleic Acids, Conjugated / metabolism; Lipid Metabolism; Obesity / diet therapy; Species Specificity
Sources: Crossref, ORCID
Added: January 20, 2020

2010 chapter

Conjugated Linoleic Acid

In Encyclopedia of Dietary Supplements, Second Edition (pp. 166–174).

By: K. Martinez, A. Kennedy* & M. McIntosh

Sources: Crossref, ORCID
Added: January 20, 2020

2010 journal article

Inflammation and insulin resistance induced bytrans-10,cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes

Journal of Lipid Research, 51(7), 1906–1917.

By: A. Kennedy*, K. Martinez*, S. Chung*, K. LaPoint*, R. Hopkins*, S. Schmidt*, K. Andersen*, S. Mandrup*, M. McIntosh*

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
author keywords: cell signaling; fatty acid; reactive oxygen species
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adult; Animals; Calcium / metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Gene Expression Regulation; Humans; Inflammation / metabolism; Insulin Resistance / physiology; JNK Mitogen-Activated Protein Kinases / metabolism; Linoleic Acids, Conjugated / chemistry; Linoleic Acids, Conjugated / metabolism; Mice; Middle Aged; Mitochondria / metabolism; NF-kappa B / metabolism; Reactive Oxygen Species / metabolism; Type C Phospholipases / metabolism; Young Adult
Sources: Crossref, ORCID
Added: January 20, 2020

2010 journal article

Mouse models of the metabolic syndrome

Disease Models & Mechanisms, 3(3-4), 156–166.

By: A. Kennedy*, K. Ellacott*, V. King* & A. Hasty*

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Disease Models, Animal; Humans; Hyperlipidemias / complications; Hyperlipidemias / pathology; Hypertension / complications; Hypertension / pathology; Insulin Resistance; Metabolic Syndrome / complications; Metabolic Syndrome / pathology; Mice; Obesity / complications; Obesity / pathology
Sources: Crossref, ORCID
Added: January 20, 2020

2010 journal article

Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes

The American Journal of Clinical Nutrition, 92(6), 1511–1521.

By: C. Chuang, K. Martinez, G. Xie, A. Kennedy*, A. Bumrungpert, A. Overman, W. Jia, M. McIntosh

MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adult; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Female; Gene Expression; Glucose / metabolism; Humans; Inflammation / drug therapy; Inflammation / genetics; Inflammation / metabolism; Insulin / metabolism; Insulin Resistance; Middle Aged; PPAR gamma / metabolism; Phosphorylation; Phytotherapy; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Quercetin / pharmacology; Quercetin / therapeutic use; Resveratrol; Signal Transduction / drug effects; Stilbenes / pharmacology; Stilbenes / therapeutic use; Transcription, Genetic / drug effects; Tumor Necrosis Factor-alpha / metabolism; Vitis / chemistry; Young Adult
Sources: Crossref, ORCID
Added: January 20, 2020

2010 journal article

trans-10,cis-12-Conjugated Linoleic Acid Instigates Inflammation in Human Adipocytes Compared with Preadipocytes

Journal of Biological Chemistry, 285(23), 17701–17712.

By: K. Martinez*, A. Kennedy*, T. West*, D. Milatovic*, M. Aschner* & M. McIntosh*

co-author countries: United States of America 🇺🇸
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Cell Differentiation; Coculture Techniques; Culture Media, Conditioned / metabolism; Fatty Acids / chemistry; Female; Humans; Inflammation; Linoleic Acids, Conjugated / chemistry; Linoleic Acids, Conjugated / metabolism; Lipids / chemistry; Lipopolysaccharides / chemistry; MAP Kinase Signaling System; Phosphorylation; RNA, Messenger / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2009 journal article

Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes

The Journal of Nutrition, 139(6), 1185–1191.

By: A. Bumrungpert*, R. Kalpravidh*, C. Chitchumroonchokchai*, C. Chuang*, T. West*, A. Kennedy*, M. McIntosh*

co-author countries: Thailand 🇹🇭 United States of America 🇺🇸
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adult; Cells, Cultured; Female; Garcinia mangostana / chemistry; Gene Expression / drug effects; Humans; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / prevention & control; Insulin Resistance / physiology; Lipopolysaccharides / toxicity; Middle Aged; Mitogen-Activated Protein Kinase Kinases / genetics; Mitogen-Activated Protein Kinase Kinases / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; RNA, Messenger / metabolism; Transcription Factor AP-1 / genetics; Transcription Factor AP-1 / metabolism; Transfection; Xanthones / chemistry; Xanthones / pharmacology; Young Adult
Sources: Crossref, ORCID
Added: January 20, 2020

2008 journal article

Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol

Journal of Lipid Research, 50(2), 225–232.

By: A. Kennedy*, A. Overman*, K. LaPoint*, R. Hopkins*, T. West*, C. Chuang*, K. Martinez*, D. Bell, M. McIntosh*

co-author countries: United States of America 🇺🇸
author keywords: stress; anti-inflammatory; delipidation
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adult; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cells, Cultured; Fatty Acids / metabolism; Humans; Inflammation Mediators / metabolism; Insulin Resistance / physiology; Linoleic Acids, Conjugated / metabolism; Middle Aged; PPAR gamma / metabolism; Resveratrol; Stilbenes / pharmacology; Transfection; Triglycerides / metabolism
Sources: Crossref, ORCID
Added: January 20, 2020

2008 journal article

Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications

The Journal of Nutrition, 139(1), 1–4.

By: A. Kennedy*, K. Martinez*, C. Chuang*, K. LaPoint* & M. McIntosh

co-author countries: United States of America 🇺🇸
MeSH headings : Adipose Tissue / metabolism; Fatty Acids / metabolism; Humans; Inflammation / metabolism; Insulin Resistance / physiology; Obesity
Sources: Crossref, ORCID
Added: January 20, 2020

2008 journal article

Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand-Dependent PPARγ Activity in Primary Cultures of Human Adipocytes

The Journal of Nutrition, 138(3), 455–461.

By: A. Kennedy*, S. Chung*, K. LaPoint*, O. Fabiyi* & M. McIntosh*

co-author countries: United States of America 🇺🇸
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Cell Differentiation; Cells, Cultured; Drug Interactions; Humans; Hypoglycemic Agents / pharmacology; Ligands; Linoleic Acids, Conjugated / pharmacology; PPAR gamma / antagonists & inhibitors; PPAR gamma / metabolism; Phosphorylation / drug effects; Rosiglitazone; Thiazolidinediones / pharmacology
Sources: Crossref, ORCID
Added: January 20, 2020

2006 journal article

Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes

Endocrinology, 147(11), 5340–5351.

By: S. Chung*, K. LaPoint*, K. Martinez*, A. Kennedy*, M. Boysen Sandberg* & M. McIntosh*

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
MeSH headings : Adipocytes / physiology; Antigens, CD / analysis; Antigens, Differentiation, Myelomonocytic / analysis; Cell Differentiation; Cells, Cultured; Cytokines / biosynthesis; Cytokines / genetics; Female; Humans; Inflammation / etiology; Insulin Resistance; Lipopolysaccharides / toxicity; Macrophage-1 Antigen / analysis; Mitogen-Activated Protein Kinases / physiology; NF-kappa B / physiology; PPAR gamma / metabolism; RNA, Messenger / analysis; Signal Transduction; Stem Cells / physiology; Toll-Like Receptors / physiology
Sources: Crossref, ORCID
Added: January 20, 2020

2004 journal article

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

Journal of Lipid Research, 45(7), 1197–1206.

By: L. Freeman*, A. Kennedy*, J. Wu*, S. Bark*, A. Remaley*, S. Santamarina-Fojo*, H. Brewer*

co-author countries: United States of America 🇺🇸
author keywords: ATP binding cassette transporter; CPF; liver receptor homolog-1; FTF; FXR; SHP; sitosterolemia cholesterol; bile acids
MeSH headings : ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Transporters / genetics; Bile Acids and Salts / metabolism; Binding Sites / genetics; Binding Sites / physiology; Cell Line, Tumor; DNA-Binding Proteins / physiology; Deoxycholic Acid / pharmacology; Humans; Lipoproteins / genetics; Promoter Regions, Genetic / drug effects; Promoter Regions, Genetic / genetics; Receptors, Cytoplasmic and Nuclear / physiology; Sterols / metabolism; Transcription Factors / physiology; Transcriptional Activation
Sources: Crossref, ORCID
Added: January 20, 2020

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