Works (38)
Updated: April 4th, 2024 12:13
2024 journal article
Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells
SCIENTIFIC REPORTS, 14(1).
TL;DR:
It is demonstrated that chronic fructose diet decreased Kupffer cell populations while increasing transitioning monocytes and upregulating resolution and anti-inflammatory associated genes in Kupffer cells.
(via Semantic Scholar)
doi.org (publisher)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2024
2024 journal article
Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis
FRONTIERS IN IMMUNOLOGY, 14.
Contributors: T. Williams n , V. Adams n, L. Collins n , J. Holmes n, P. Hess n , H. Atkins n, G. Scheidemantle n, X. Liu n
Ed(s): T. Williams n , L. Collins n & n
author keywords: liver; NASH; fibrosis; H2Kb; CD8(+) T cells; immunopeptidome
TL;DR:
Activated hepatic CD8+ T cells are dependent on myeloid cell MHC class I expression in diet induced NASH to promote inflammation and fibrosis and a role of NADPH oxidase in the production of Ncf2 peptide generation is suggested.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 28, 2024
2022 journal article
Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1867(1).
author keywords: N-3 polyunsaturated fatty acids; bacteria; Microbial; Lipidomics
MeSH headings : Akkermansia / genetics; Akkermansia / growth & development; Animals; Cardiometabolic Risk Factors; Cell Differentiation / drug effects; Diet, High-Fat / adverse effects; Eicosapentaenoic Acid / metabolism; Eicosapentaenoic Acid / pharmacology; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / genetics; Glucose / metabolism; Humans; Hydroxyeicosatetraenoic Acids / biosynthesis; Hydroxyeicosatetraenoic Acids / blood; Male; Mass Spectrometry; Mice; Mice, Obese / genetics; Mice, Obese / microbiology; Phosphatidylinositol 3-Kinases / genetics; Proto-Oncogene Proteins c-akt / genetics; RNA, Ribosomal, 16S / genetics; Sex Characteristics; Th17 Cells / metabolism; Triglycerides / blood
TL;DR:
Results show that EPA ethyl esters prevent some of the deleterious effects of a high fat diet in female mice, which may be mediated mechanistically through 8-HEPE and the upregulation of intestinal Akkermansia muciniphila.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2022 journal article
Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis
METABOLOMICS, 18(8).
MeSH headings : Animals; Cardiolipins; Chromatography, Liquid / methods; Ions; Lipidomics; Metabolomics; Mice; Reproducibility of Results; Tandem Mass Spectrometry / methods
TL;DR:
A novel workflow using biologically relevant lipids to construct inclusion list for data-independent acquisition (DIA), named as BRI-DIA workflow, which is as efficient as traditional DDA method in profiling lipids, but offers better consistency of lipid identification, compared to D DA method.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022
2020 journal article
CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease
American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(2), G211–G224.
author keywords: CD8(+) T cells; lymphocytes; nonalcoholic steatohepatitis; stellate cells
MeSH headings : Animals; CD8-Positive T-Lymphocytes / pathology; Hepatic Stellate Cells / drug effects; Hepatitis / pathology; Humans; Hyperlipidemias / pathology; Interleukin-10 / biosynthesis; Liver / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease / complications; Non-alcoholic Fatty Liver Disease / pathology; Obesity / etiology; Obesity / pathology; Receptors, LDL / genetics; Receptors, LDL / metabolism
TL;DR:
It is demonstrated that under obese/hyperlipidemia conditions, CD8+T cell are key regulators of the progression of NASH, while under non-obese conditions they play a minimal role in driving the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2020 journal article
Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health
DIABETES, 69(3), 342–354.
MeSH headings : Acinar Cells / pathology; Acinar Cells / ultrastructure; Adolescent; Adult; Age Factors; Aged; Animals; Child; Child, Preschool; Diabetes Mellitus, Experimental / pathology; Diabetes Mellitus, Type 2 / pathology; Embryonic Stem Cells; Female; Glucagon-Secreting Cells / pathology; Glucagon-Secreting Cells / ultrastructure; Humans; Infant; Insulin-Secreting Cells / pathology; Insulin-Secreting Cells / ultrastructure; Islets of Langerhans / cytology; Islets of Langerhans / pathology; Islets of Langerhans / ultrastructure; Islets of Langerhans Transplantation; Lipid Droplets / pathology; Lipid Droplets / ultrastructure; Male; Mice; Microscopy, Electron; Microscopy, Fluorescence; Middle Aged; Rats; Tissue Donors; Young Adult
TL;DR:
There appear to be significant differences in pancreas islet cell lipid handling between species, and the human juvenile and adult cell populations, and this results suggest that LD enrichment could be impactful to T2D islet Cell function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 16, 2020
2018 journal article
Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons
JAIDS Journal of Acquired Immune Deficiency Syndromes, 77(2), e14–e21.
author keywords: HIV; obesity; metabolic disease; adipose tissue; T-cell receptor; clonality
MeSH headings : Adipose Tissue / pathology; Adult; Anti-HIV Agents / therapeutic use; Blood Cells; CD8-Positive T-Lymphocytes / chemistry; CD8-Positive T-Lymphocytes / immunology; Cohort Studies; Female; HIV Infections / drug therapy; HIV Infections / pathology; Humans; Male; Middle Aged; Receptors, Antigen, T-Cell / analysis; Sequence Analysis, DNA; Sustained Virologic Response; T-Lymphocyte Subsets / chemistry; T-Lymphocyte Subsets / immunology
TL;DR:
Adipose tissue is enriched for activated and late-differentiated CD8+ T cells with distinct TCR usage, which may contribute to tissue inflammation and impaired adipocyte fitness in HIV-infected persons.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2018 journal article
Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments
Molecular Metabolism, 8, 86–95.
author keywords: Inflammation; Obesity; Diabetes; Eosinophils; Interleukin 5; Adipose tissue
MeSH headings : Adipose Tissue / drug effects; Adipose Tissue / pathology; Animals; Energy Metabolism; Eosinophils / drug effects; Insulin / metabolism; Interleukin-5 / pharmacology; Interleukin-5 / therapeutic use; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Obesity / pathology
TL;DR:
It is shown that restoring obese AT eosinophils to lean healthy levels is not sufficient to allow for improvement in any of a range of metabolic features otherwise impaired in obesity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 22, 2020
2018 journal article
High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity
Diabetes, 67(11), 2361–2376.
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Animals; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Complementarity Determining Regions / metabolism; Diet, High-Fat; Glucose Tolerance Test; Insulin Resistance; Liver / immunology; Liver / metabolism; Male; Mice; Obesity / immunology; Obesity / metabolism; Prostaglandins / metabolism
TL;DR:
It is demonstrated that clonal TCR expansion that favors positively charged CDR3s accompanies HFD-induced obesity, which may be an antigen-driven response to isoLG accumulation in macrophages.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2018 journal article
MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice
American Journal of Physiology-Cell Physiology, 315(3), C319–C329.
author keywords: adipose; homeostasis; iron; macrophage; polarization
MeSH headings : Adipocytes / metabolism; Adipocytes / physiology; Adipose Tissue / metabolism; Adipose Tissue / physiology; Animals; Cell Line; Dietary Supplements; Inflammation / metabolism; Inflammation / physiopathology; Iron Overload / metabolism; Iron Overload / physiopathology; Iron, Dietary / metabolism; Macrophages / metabolism; Macrophages / physiology; Male; Mice; Mice, Inbred C57BL; Monocytes / metabolism; Monocytes / physiology
TL;DR:
Two methodologies were used to address how MFehi ATMs may respond to and influence adipose tissue iron availability and confirm that they can respond as a tissue iron sink in models of iron overload.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2018 journal article
Macrophage-Targeted Therapeutics for Metabolic Disease
Trends Pharmacological Sciences, 39, 536–546.
MeSH headings : Drug Delivery Systems / methods; Gene Expression / drug effects; Humans; Macrophages / drug effects; Macrophages / immunology; Metabolic Diseases / drug therapy; Metabolic Diseases / immunology; Molecular Targeted Therapy; Pharmaceutical Preparations / administration & dosage
TL;DR:
This review discusses advances in potential therapeutics for metabolic diseases via macrophage-specific delivery and highlights micro- and nanoparticles, liposomes, and oligopeptide complexes, and how they can be used to alter macrophages phenotype for a more metabolically favorable tissue environment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 20, 2020
2018 journal article
Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention
Physiological Reports, 6(22), e13919.
author keywords: Adipose tissue; eosinophils; inflammation; macrophages; obesity; weight loss
MeSH headings : Adipose Tissue / pathology; Animals; Caloric Restriction; Cells, Cultured; Eosinophils / pathology; Male; Mice; Mice, Inbred C57BL; Obesity / diet therapy; Obesity / pathology; Weight Loss
TL;DR:
It is shown that eosinophil content is differentially regulated among tissues during the onset and resolution of obesity and correlated with AT remodeling processes during weight loss and thus may play a role in reestablishing AT homeostasis.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2016 journal article
CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice
Physiological Reports, 4(18), e12971.
author keywords: Adipose tissue; CCR7; macrophages; obesity; T cells
MeSH headings : Adipose Tissue / metabolism; Adipose Tissue / pathology; Animals; CD8-Positive T-Lymphocytes / metabolism; Diet, High-Fat / adverse effects; Fatty Liver / etiology; Fatty Liver / metabolism; Fatty Liver / pathology; Interleukins / metabolism; Macrophage Activation; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Obesity / etiology; Obesity / metabolism; Obesity / pathology; Receptors, CCR7 / genetics; Receptors, CCR7 / metabolism; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Data suggest that CCR7 plays a role in CD8+ATT cell egress, but does not influence ATM accumulation or the metabolic impact of diet‐induced obesity.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2016 journal article
Role of lipids in the metabolism and activation of immune cells
The Journal of Nutritional Biochemistry, 34, 1–7.
author keywords: Inflammation; Macrophages; T lymphocytes; Oxysterols; Fatty acids
TL;DR:
The purpose of this review is to discuss lipids and their impact on innate and adaptive immune responses, focusing on the impact of altering lipid metabolism on immune cell activation, differentiation and function and the mechanism by which lipids such as cholesterol and fatty acids regulate immune cell plasticity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2015 journal article
Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment
Molecular Metabolism, 4(10), 665–677.
author keywords: Adipose tissue; Macrophage; Apoptosis; Cleaved caspase-3; NF-kappa B; Survival
TL;DR:
It is shown that obesity promotes survival of inflammatory ATMs, possibly through an NF-κB-regulated mechanism, and activation of apoptotic pathways is significantly reduced in ATMs from diet-induced and genetically obese mice.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2015 journal article
CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue
Journal of Leukocyte Biology, 98(4), 467–477.
author keywords: inflammation; obesity; interleukin 5
MeSH headings : Adipose Tissue / immunology; Animals; Cell Separation; Eosinophils / immunology; Flow Cytometry; Immunohistochemistry; Inflammation / immunology; Insulin Resistance / immunology; Interleukin-13 / biosynthesis; Interleukin-4 / biosynthesis; Interleukin-5 / biosynthesis; Macrophage Activation / immunology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity / immunology; Real-Time Polymerase Chain Reaction; Receptors, CCR2 / immunology
TL;DR:
It is shown that CCR2 deficiency leads to increased eosinophil accumulation in AT, and this is the first study to link C CR2 function with regulation of AT eos inophil collection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2013 journal article
Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance
Diabetes, 62(6), 1888–1896.
MeSH headings : Animals; Cell Adhesion Molecules / therapeutic use; Diet, High-Fat / adverse effects; Hyaluronic Acid / metabolism; Hyaluronoglucosaminidase / therapeutic use; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Insulin Resistance / physiology; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Obesity / drug therapy; Obesity / etiology; Obesity / metabolism
TL;DR:
It is suggested that ECM HA is a target for treatment of insulin resistance by showing that muscle HA was increased in HF diet–induced obese (DIO) mice and that treatment of PEGPH20 dose-dependently reduced HA in muscle ECM, decreased fat mass, adipocyte size, and hepatic and muscle insulin resistance in DIO mice at 10 mg/kg.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2013 journal article
Isolation of Adipose Tissue Immune Cells
Journal of Visualized Experiments, 5(75).
author keywords: Immunology; Issue 75; Cellular Biology; Molecular Biology; Biophysics; Physiology; Anatomy; Biomedical Engineering; Surgery; Metabolic Diseases; Diabetes Mellitus; diabetes; Endocrine System Diseases; adipose tissue; AT; stromal vascular fraction; macrophage; lymphocyte; T cells; adipocyte; inflammation; obesity; cell; isolation; FACS; flow cytometry; mice; animal model
TL;DR:
This video demonstrates how to mince, digest, and isolate the immune cell-enriched stromal vascular fraction and shows how to antibody label macrophages and T lymphocytes and how to properly gate on them in flow cytometry experiments.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2013 journal article
Loss of CCR5 results in glucose intolerance in diet-induced obese mice
American Journal of Physiology-Endocrinology and Metabolism, 305(7), E897–E906.
author keywords: C-C chemokine receptor 5; diet-induced obesity; macrophages; T cells; inflammation; insulin resistance; adipose tissue
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Animals; Glucose / metabolism; Glucose Intolerance / genetics; Glucose Intolerance / immunology; Glucose Intolerance / metabolism; Inflammation / genetics; Inflammation / immunology; Inflammation / metabolism; Insulin / metabolism; Insulin Resistance / immunology; Insulin Resistance / physiology; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Knockout; Mice, Obese; Muscle, Skeletal / immunology; Muscle, Skeletal / metabolism; Receptors, CCR5 / genetics; Receptors, CCR5 / metabolism
TL;DR:
Findings suggest that whereas CCR5 plays a minor role in regulating immune cell infiltration and inflammation in metabolic tissues, deficiency of C CR5 impairs systemic glucose tolerance as well as AT and muscle insulin signaling.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2013 journal article
Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution
Diabetes, 63(2), 421–432.
MeSH headings : Adipose Tissue / cytology; Animals; Dietary Fats / adverse effects; Gene Expression Regulation; Iron / metabolism; Macrophages / chemistry; Macrophages / metabolism; Male; Mice; Obesity / chemically induced; Tissue Distribution
TL;DR:
In obesity, iron distribution is altered both at the cellular and tissue levels, with AT playing a predominant role in this change, and an increased availability of fatty acids during obesity may contribute to the observed changes in MFehi ATM phenotype and their reduced capacity to handle iron.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2013 journal article
Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance
Diabetes, 62(9), 3180–3188.
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Animals; Blotting, Western; Body Composition / physiology; Body Weight / physiology; CD4-Positive T-Lymphocytes / metabolism; CD8-Positive T-Lymphocytes / metabolism; Flow Cytometry; Glucose Tolerance Test; Insulin Resistance / physiology; Male; Mice; Mice, Inbred C57BL; Obesity / metabolism; Obesity / physiopathology; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
It is indicated that an exaggerated adaptive immune response in AT may contribute to metabolic dysfunction during weight cycling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2012 journal article
Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes
Journal of Lipid Research, 54(3), 662–670.
author keywords: interleukins; intracellular calcium; lipogenic genes; delipidation
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Calcium / metabolism; Cells, Cultured; Chemokine CCL2 / metabolism; Diacylglycerol Kinase / antagonists & inhibitors; Diacylglycerol Kinase / genetics; Diacylglycerol Kinase / metabolism; Enzyme Inhibitors; Humans; Inflammation / chemically induced; Inflammation / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Linoleic Acids, Conjugated / pharmacology; Pyrimidinones / pharmacology; Thiazoles / pharmacology
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2012 journal article
Impact of Macrophage Inflammatory Protein-1α Deficiency on Atherosclerotic Lesion Formation, Hepatic Steatosis, and Adipose Tissue Expansion
PLoS One, 7(2), e31508.
MeSH headings : Adipose Tissue / pathology; Animals; Atherosclerosis / etiology; Atherosclerosis / pathology; Body Weight; Bone Marrow Transplantation; Chemokine CCL3 / deficiency; Chemokine CCL3 / physiology; Diet; Fatty Liver / etiology; Female; Hyperlipidemias; Lipid Metabolism; Lipids / blood; Male; Mice; Mice, Knockout
TL;DR:
Data implicate a role for CCL3 in lipid metabolism in hyperlipidemic mice following hematopoietic reconstitution and there were no differences in myeloid progenitors or leukocyte populations, indicating that changes in body weight and plasma lipids in CCL 3−/− recipients was not due to differences in hematoiesis.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 22, 2020
2011 journal article
Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity
Diabetes, 60(11), 2820–2829.
MeSH headings : Adipose Tissue / immunology; Adipose Tissue / metabolism; Adipose Tissue / pathology; Animals; Antigens, Differentiation / metabolism; Dietary Fats / adverse effects; Disease Progression; Glucose Intolerance / etiology; Glucose Intolerance / immunology; Glucose Intolerance / metabolism; Glucose Intolerance / pathology; Glucose Tolerance Test; Insulin Resistance; Interferon-gamma / metabolism; Interleukin-4 / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells / immunology; Myeloid Cells / metabolism; Myeloid Cells / pathology; Obesity / immunology; Obesity / metabolism; Obesity / pathology; Obesity / physiopathology; Organ Specificity; Receptors, CCR2 / genetics; Receptors, CCR2 / physiology; Time Factors
TL;DR:
The discovery of this novel adipose tissue monocytic cell population provides advances toward understanding the pleiotropic role of CCR2 in monocyte/macrophage accumulation and regulation of adipose tissues inflammation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2011 journal article
Grape powder extract attenuates tumor necrosis factor α-mediated inflammation and insulin resistance in primary cultures of human adipocytes
The Journal of Nutritional Biochemistry, 22(1), 89–94.
author keywords: Grapes; Grape powder extract; Adipocytes; Inflammation; Insulin resistance
MeSH headings : Abdominal Fat / cytology; Abdominal Fat / drug effects; Abdominal Fat / metabolism; Adult; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Anti-Obesity Agents / pharmacology; Cells, Cultured; Female; Fruit / chemistry; Gene Expression Regulation / drug effects; Humans; Inflammation Mediators / metabolism; Insulin Receptor Substrate Proteins / metabolism; Insulin Resistance; Middle Aged; Phosphorylation / drug effects; Phytotherapy; Plant Extracts / pharmacology; Protein Tyrosine Phosphatase, Non-Receptor Type 1 / genetics; Protein Tyrosine Phosphatase, Non-Receptor Type 1 / metabolism; RNA, Messenger / metabolism; Signal Transduction / drug effects; Tumor Necrosis Factor-alpha / metabolism; Vitis / chemistry; Young Adult
TL;DR:
Data demonstrate that GPE attenuates TNFα-mediated inflammation and insulin resistance in human adipocytes, possibly by suppressing the activation of ERK, JNK, c-Jun and NF-κB.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2011 journal article
JNK Inhibition by SP600125 Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Regulation of Inflammatory and Lipogenic Gene Expression
Lipids, 46(10), 885–892.
author keywords: Conjugated linoleic acid; Adipocytes; JNK; cJun; Inflammation; Lipogenic genes
MeSH headings : Activating Transcription Factor 3 / immunology; Adipocytes / drug effects; Adipocytes / immunology; Adult; Anthracenes / pharmacology; Cells, Cultured; Female; Gene Expression Regulation / drug effects; Humans; Inflammation / drug therapy; Insulin Resistance; JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors; Linoleic Acids, Conjugated / immunology; Lipogenesis / drug effects; Middle Aged; Signal Transduction / drug effects; Young Adult
TL;DR:
The extent to which blocking c-Jun NH2-terminal kinase (JNK) signaling using the JNK inhibitor SP600125 attenuated markers of inflammation and insulin resistance in primary human adipocytes treated with t10,c12 CLA is examined, suggesting that JNK signaling plays an important role in t 10,c 12 CLA-mediated regulation of inflammatory and lipogenic gene expression in primary cultures of human adipocyte.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2010 journal article
Antiobesity mechanisms of action of conjugated linoleic acid
The Journal of Nutritional Biochemistry, 21(3), 171–179.
author keywords: CIA; Obesity; Adipose tissue; Energy metabolism; PPAR gamma; Adipogenesis; Inflammation
MeSH headings : Adipogenesis; Adiposity; Animals; Apoptosis; Body Weight; Dietary Fats, Unsaturated / administration & dosage; Dietary Fats, Unsaturated / metabolism; Dietary Supplements; Energy Metabolism; Humans; Inflammation; Linoleic Acids, Conjugated / administration & dosage; Linoleic Acids, Conjugated / metabolism; Lipid Metabolism; Obesity / diet therapy; Species Specificity
TL;DR:
In vivo and in vitro findings from the literature regarding potential mechanisms by which CLA reduces adiposity are summarized, including its impact on energy metabolism, adipogenesis, inflammation, lipid metabolism and apoptosis.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2010 chapter
Conjugated Linoleic Acid
In Encyclopedia of Dietary Supplements, Second Edition (pp. 166–174).
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2010 journal article
Inflammation and insulin resistance induced bytrans-10,cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes
Journal of Lipid Research, 51(7), 1906–1917.
author keywords: cell signaling; fatty acid; reactive oxygen species
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adult; Animals; Calcium / metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases / metabolism; Female; Gene Expression Regulation; Humans; Inflammation / metabolism; Insulin Resistance / physiology; JNK Mitogen-Activated Protein Kinases / metabolism; Linoleic Acids, Conjugated / chemistry; Linoleic Acids, Conjugated / metabolism; Mice; Middle Aged; Mitochondria / metabolism; NF-kappa B / metabolism; Reactive Oxygen Species / metabolism; Type C Phospholipases / metabolism; Young Adult
TL;DR:
The data suggest that 10,12 CLA increases inflammation and insulin resistance in human adipocytes, in part by increasing [Ca2+]i levels, particularly calcium from the ER.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2010 journal article
Mouse models of the metabolic syndrome
Disease Models & Mechanisms, 3(3-4), 156–166.
MeSH headings : Animals; Disease Models, Animal; Humans; Hyperlipidemias / complications; Hyperlipidemias / pathology; Hypertension / complications; Hypertension / pathology; Insulin Resistance; Metabolic Syndrome / complications; Metabolic Syndrome / pathology; Mice; Obesity / complications; Obesity / pathology
TL;DR:
This review will focus on the benefits and caveats of the most common mouse models of MetS, which have been used for decades to determine the pathophysiological basis for MetS and how MetS increases the risk for other diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2010 journal article
Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes
The American Journal of Clinical Nutrition, 92(6), 1511–1521.
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adult; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Female; Gene Expression; Glucose / metabolism; Humans; Inflammation / drug therapy; Inflammation / genetics; Inflammation / metabolism; Insulin / metabolism; Insulin Resistance; Middle Aged; PPAR gamma / metabolism; Phosphorylation; Phytotherapy; Plant Extracts / pharmacology; Plant Extracts / therapeutic use; Quercetin / pharmacology; Quercetin / therapeutic use; Resveratrol; Signal Transduction / drug effects; Stilbenes / pharmacology; Stilbenes / therapeutic use; Transcription, Genetic / drug effects; Tumor Necrosis Factor-alpha / metabolism; Vitis / chemistry; Young Adult
TL;DR:
It is suggested that quercetin is equally or more effective than trans-RSV in attenuating TNF-α-mediated inflammation and insulin resistance in primary human adipocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2010 journal article
trans-10,cis-12-Conjugated Linoleic Acid Instigates Inflammation in Human Adipocytes Compared with Preadipocytes
Journal of Biological Chemistry, 285(23), 17701–17712.
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Cell Differentiation; Coculture Techniques; Culture Media, Conditioned / metabolism; Fatty Acids / chemistry; Female; Humans; Inflammation; Linoleic Acids, Conjugated / chemistry; Linoleic Acids, Conjugated / metabolism; Lipids / chemistry; Lipopolysaccharides / chemistry; MAP Kinase Signaling System; Phosphorylation; RNA, Messenger / metabolism
TL;DR:
The data suggest that CLA instigates the release of inflammatory signals from adipocytes that subsequently activate adjacent preadipocytes and prevent the inflammatory capacity of CM from 10,12-CLA-treated cultures.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2009 journal article
Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes
The Journal of Nutrition, 139(6), 1185–1191.
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Adult; Cells, Cultured; Female; Garcinia mangostana / chemistry; Gene Expression / drug effects; Humans; Inflammation / chemically induced; Inflammation / drug therapy; Inflammation / prevention & control; Insulin Resistance / physiology; Lipopolysaccharides / toxicity; Middle Aged; Mitogen-Activated Protein Kinase Kinases / genetics; Mitogen-Activated Protein Kinase Kinases / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; RNA, Messenger / metabolism; Transcription Factor AP-1 / genetics; Transcription Factor AP-1 / metabolism; Transfection; Xanthones / chemistry; Xanthones / pharmacology; Young Adult
TL;DR:
It is demonstrated that MG attenuates LPS-mediated inflammation and insulin resistance in human adipocytes, possibly by inhibiting the activation of MAPK, NF-kappaB, and AP-1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2008 journal article
Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol
Journal of Lipid Research, 50(2), 225–232.
author keywords: stress; anti-inflammatory; delipidation
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adult; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cells, Cultured; Fatty Acids / metabolism; Humans; Inflammation Mediators / metabolism; Insulin Resistance / physiology; Linoleic Acids, Conjugated / metabolism; Middle Aged; PPAR gamma / metabolism; Resveratrol; Stilbenes / pharmacology; Transfection; Triglycerides / metabolism
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2008 journal article
Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications
The Journal of Nutrition, 139(1), 1–4.
MeSH headings : Adipose Tissue / metabolism; Fatty Acids / metabolism; Humans; Inflammation / metabolism; Insulin Resistance / physiology; Obesity
TL;DR:
Reducing consumption of foods rich in SFA and increasing consumption of whole grains, fruits, vegetables, lean meats and poultry, fish, low-fat dairy products, and oils containing oleic acid or (n-3) FA is likely to reduce the incidence of metabolic disease.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2008 journal article
Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand-Dependent PPARγ Activity in Primary Cultures of Human Adipocytes
The Journal of Nutrition, 138(3), 455–461.
MeSH headings : Adipocytes / drug effects; Adipocytes / metabolism; Cell Differentiation; Cells, Cultured; Drug Interactions; Humans; Hypoglycemic Agents / pharmacology; Ligands; Linoleic Acids, Conjugated / pharmacology; PPAR gamma / antagonists & inhibitors; PPAR gamma / metabolism; Phosphorylation / drug effects; Rosiglitazone; Thiazolidinediones / pharmacology
TL;DR:
It is demonstrated for the first time, to the knowledge, that 10,12 CLA antagonizes ligand-dependent PPARgamma activity, possibly via PPARGamma phosphorylation by ERK.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2006 journal article
Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes
Endocrinology, 147(11), 5340–5351.
MeSH headings : Adipocytes / physiology; Antigens, CD / analysis; Antigens, Differentiation, Myelomonocytic / analysis; Cell Differentiation; Cells, Cultured; Cytokines / biosynthesis; Cytokines / genetics; Female; Humans; Inflammation / etiology; Insulin Resistance; Lipopolysaccharides / toxicity; Macrophage-1 Antigen / analysis; Mitogen-Activated Protein Kinases / physiology; NF-kappa B / physiology; PPAR gamma / metabolism; RNA, Messenger / analysis; Signal Transduction; Stem Cells / physiology; Toll-Like Receptors / physiology
TL;DR:
It is demonstrated that LPS induces nuclear factor-kappaB- and MAPK-dependent proinflammatory cytokine/chemokine expression primarily in preadipocytes, which triggers the suppression of PPARgamma activity and insulin responsiveness in human adipocytes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
2004 journal article
The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter
Journal of Lipid Research, 45(7), 1197–1206.
author keywords: ATP binding cassette transporter; CPF; liver receptor homolog-1; FTF; FXR; SHP; sitosterolemia cholesterol; bile acids
MeSH headings : ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Cassette Transporter, Subfamily G, Member 8; ATP-Binding Cassette Transporters / genetics; Bile Acids and Salts / metabolism; Binding Sites / genetics; Binding Sites / physiology; Cell Line, Tumor; DNA-Binding Proteins / physiology; Deoxycholic Acid / pharmacology; Humans; Lipoproteins / genetics; Promoter Regions, Genetic / drug effects; Promoter Regions, Genetic / genetics; Receptors, Cytoplasmic and Nuclear / physiology; Sterols / metabolism; Transcription Factors / physiology; Transcriptional Activation
TL;DR:
It is demonstrated that LRH-1 is a positive transcription factor for ABCG5 and ABCG8 and a “master regulator” for genes involved in sterol and bile acid secretion from liver and intestine through the farnesoid X receptor-small heterodimeric partner-LRH- 1 pathway.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 20, 2020
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