Arion Kennedy

Lodge, M., Scheidemantle, G., Adams, V. R., Cottam, M. A., Richard, D., Breuer, D., … Kennedy, A. (2024). Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells. SCIENTIFIC REPORTS, 14(1). https://doi.org/10.1038/s41598-024-54272-w

Adams, V. R., Collins, L. B., Williams, T. I., Holmes, J., Hess, P., Atkins, H. M., … Kennedy, A. (2024). Myeloid cell MHC I expression drives CD8<SUP>+</SUP> T cell activation in nonalcoholic steatohepatitis. FRONTIERS IN IMMUNOLOGY, 14. https://doi.org/10.3389/fimmu.2023.1302006

Pal, A., Sun, S., Armstrong, M., Manke, J., Reisdorph, N., Adams, V. R., … Shaikh, S. R. (2022). Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1867(1). https://doi.org/10.1016/j.bbalip.2021.159059

Duan, L., Scheidemantle, G., Lodge, M., Cummings, M. J., Pham, E., Wang, X., … Liu, X. (2022). Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC-MS/MS-based lipidomics analysis. METABOLOMICS, 18(8). https://doi.org/10.1007/s11306-022-01913-8

Breuer, D. A., Pacheco, M. C., Washington, M. K., Montgomery, S. A., Hasty, A. H., & Kennedy, A. J. (2020). CD8+ T cells regulate liver injury in obesity-related nonalcoholic fatty liver disease. American Journal of Physiology-Gastrointestinal and Liver Physiology, 318(2), G211–G224. https://doi.org/10.1152/ajpgi.00040.2019

Tong, X., Dai, C., Walker, J. T., Nair, G. G., Kennedy, A., Carr, R. M., … Stein, R. (2020). Lipid Droplet Accumulation in Human Pancreatic Islets Is Dependent On Both Donor Age and Health. DIABETES, 69(3), 342–354. https://doi.org/10.2337/db19-0281

Koethe, J. R., McDonnell, W., Kennedy, A., Abana, C. O., Pilkinton, M., Setliff, I., … Mallal, S. (2018). Adipose Tissue is Enriched for Activated and Late-Differentiated CD8+ T Cells and Shows Distinct CD8+ Receptor Usage, Compared With Blood in HIV-Infected Persons. JAIDS Journal of Acquired Immune Deficiency Syndromes, 77(2), e14–e21. https://doi.org/10.1097/qai.0000000000001573

Bolus, W. R., Peterson, K. R., Hubler, M. J., Kennedy, A. J., Gruen, M. L., & Hasty, A. H. (2018). Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabolic impairments. Molecular Metabolism, 8, 86–95. https://doi.org/10.1016/j.molmet.2017.12.004

McDonnell, W. J., Koethe, J. R., Mallal, S. A., Pilkinton, M. A., Kirabo, A., Ameka, M. K., … Kennedy, A. J. (2018). High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity. Diabetes, 67(11), 2361–2376. https://doi.org/10.2337/db18-0040

Hubler, M. J., Erikson, K. M., Kennedy, A. J., & Hasty, A. H. (2018). MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice. American Journal of Physiology-Cell Physiology, 315(3), C319–C329. https://doi.org/10.1152/ajpcell.00103.2018

Peterson, K. R., Cottam, M. A., Kennedy, A. J., & Hasty, A. H. (2018). Macrophage-Targeted Therapeutics for Metabolic Disease. Trends Pharmacological Sciences, 39, 536–546. https://doi.org/10.1016/j.tips.2018.03.001

Bolus, W. R., Kennedy, A. J., & Hasty, A. H. (2018). Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention. Physiological Reports, 6(22), e13919. https://doi.org/10.14814/phy2.13919

Orr, J. S., Kennedy, A. J., Hill, A. A., Anderson-Baucum, E. K., Hubler, M. J., & Hasty, A. H. (2016). CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice. Physiological Reports, 4(18), e12971. https://doi.org/10.14814/phy2.12971

Hubler, M. J., & Kennedy, A. J. (2016). Role of lipids in the metabolism and activation of immune cells. The Journal of Nutritional Biochemistry, 34, 1–7. https://doi.org/10.1016/j.jnutbio.2015.11.002

Hill, A. A., Anderson-Baucum, E. K., Kennedy, A. J., Webb, C. D., Yull, F. E., & Hasty, A. H. (2015). Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic environment. Molecular Metabolism, 4(10), 665–677. https://doi.org/10.1016/j.molmet.2015.07.005

Bolus, W. R., Gutierrez, D. A., Kennedy, A. J., Anderson-Baucum, E. K., & Hasty, A. H. (2015). CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue. Journal of Leukocyte Biology, 98(4), 467–477. https://doi.org/10.1189/jlb.3hi0115-018r

Kang, L., Lantier, L., Kennedy, A., Bonner, J. S., Mayes, W. H., Bracy, D. P., … Wasserman, D. H. (2013). Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance. Diabetes, 62(6), 1888–1896. https://doi.org/10.2337/db12-1502

Orr, J. S., Kennedy, A. J., & Hasty, A. H. (2013). Isolation of Adipose Tissue Immune Cells. Journal of Visualized Experiments, 5(75). https://doi.org/10.3791/50707

Kennedy, A., Webb, C. D., Hill, A. A., Gruen, M. L., Jackson, L. G., & Hasty, A. H. (2013). Loss of CCR5 results in glucose intolerance in diet-induced obese mice. American Journal of Physiology-Endocrinology and Metabolism, 305(7), E897–E906. https://doi.org/10.1152/ajpendo.00177.2013

Orr, J. S., Kennedy, A., Anderson-Baucum, E. K., Webb, C. D., Fordahl, S. C., Erikson, K. M., … Hasty, A. H. (2013). Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron Distribution. Diabetes, 63(2), 421–432. https://doi.org/10.2337/db13-0213

Anderson, E. K., Gutierrez, D. A., Kennedy, A., & Hasty, A. H. (2013). Weight Cycling Increases T-Cell Accumulation in Adipose Tissue and Impairs Systemic Glucose Tolerance. Diabetes, 62(9), 3180–3188. https://doi.org/10.2337/db12-1076

Martinez, K., Shyamasundar, S., Kennedy, A., Chuang, C. C., Marsh, A., Kincaid, J., … McIntosh, M. (2012). Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. Journal of Lipid Research, 54(3), 662–670. https://doi.org/10.1194/jlr.m031211

Kennedy, A., Gruen, M., Gutierrez, D., Surmi, B., Orr, J., Webb, C., & Hasty, A. (2012). Impact of Macrophage Inflammatory Protein-1α Deficiency on Atherosclerotic Lesion Formation, Hepatic Steatosis, and Adipose Tissue Expansion. PLoS One, 7(2), e31508. https://doi.org/10.1371/journal.pone.0031508

Gutierrez, D. A., Kennedy, A., Orr, J. S., Anderson, E. K., Webb, C. D., Gerrald, W. K., & Hasty, A. H. (2011). Aberrant Accumulation of Undifferentiated Myeloid Cells in the Adipose Tissue of CCR2-Deficient Mice Delays Improvements in Insulin Sensitivity. Diabetes, 60(11), 2820–2829. https://doi.org/10.2337/db11-0314

Chuang, C.-C., Bumrungpert, A., Kennedy, A., Overman, A., West, T., Dawson, B., & McIntosh, M. K. (2011). Grape powder extract attenuates tumor necrosis factor α-mediated inflammation and insulin resistance in primary cultures of human adipocytes. The Journal of Nutritional Biochemistry, 22(1), 89–94. https://doi.org/10.1016/j.jnutbio.2009.12.002

Martinez, K., Kennedy, A., & McIntosh, M. K. (2011). JNK Inhibition by SP600125 Attenuates trans-10, cis-12 Conjugated Linoleic Acid-Mediated Regulation of Inflammatory and Lipogenic Gene Expression. Lipids, 46(10), 885–892. https://doi.org/10.1007/s11745-011-3587-4

Kennedy, A., Martinez, K., Schmidt, S., Mandrup, S., LaPoint, K., & McIntosh, M. (2010). Antiobesity mechanisms of action of conjugated linoleic acid. The Journal of Nutritional Biochemistry, 21(3), 171–179. https://doi.org/10.1016/j.jnutbio.2009.08.003

Martinez, K., Kennedy, A., & McIntosh, M. (2010). Conjugated Linoleic Acid. In Encyclopedia of Dietary Supplements, Second Edition (pp. 166–174). https://doi.org/10.1201/b14669-24

Kennedy, A., Martinez, K., Chung, S., LaPoint, K., Hopkins, R., Schmidt, S. F., … McIntosh, M. (2010). Inflammation and insulin resistance induced bytrans-10,cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes. Journal of Lipid Research, 51(7), 1906–1917. https://doi.org/10.1194/jlr.m005447

Kennedy, A. J., Ellacott, K. L. J., King, V. L., & Hasty, A. H. (2010). Mouse models of the metabolic syndrome. Disease Models & Mechanisms, 3(3-4), 156–166. https://doi.org/10.1242/dmm.003467

Chuang, C.-C., Martinez, K., Xie, G., Kennedy, A., Bumrungpert, A., Overman, A., … McIntosh, M. K. (2010). Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-α–mediated inflammation and insulin resistance in primary human adipocytes. The American Journal of Clinical Nutrition, 92(6), 1511–1521. https://doi.org/10.3945/ajcn.2010.29807

Martinez, K., Kennedy, A., West, T., Milatovic, D., Aschner, M., & McIntosh, M. (2010). trans-10,cis-12-Conjugated Linoleic Acid Instigates Inflammation in Human Adipocytes Compared with Preadipocytes. Journal of Biological Chemistry, 285(23), 17701–17712. https://doi.org/10.1074/jbc.m109.043976

Bumrungpert, A., Kalpravidh, R. W., Chitchumroonchokchai, C., Chuang, C.-C., West, T., Kennedy, A., & McIntosh, M. (2009). Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes. The Journal of Nutrition, 139(6), 1185–1191. https://doi.org/10.3945/jn.109.106617

Kennedy, A., Overman, A., LaPoint, K., Hopkins, R., West, T., Chuang, C.-C., … McIntosh, M. (2008). Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol. Journal of Lipid Research, 50(2), 225–232. https://doi.org/10.1194/jlr.m800258-jlr200

Kennedy, A., Martinez, K., Chuang, C.-C., LaPoint, K., & McIntosh, M. (2008). Saturated Fatty Acid-Mediated Inflammation and Insulin Resistance in Adipose Tissue: Mechanisms of Action and Implications. The Journal of Nutrition, 139(1), 1–4. https://doi.org/10.3945/jn.108.098269

Kennedy, A., Chung, S., LaPoint, K., Fabiyi, O., & McIntosh, M. K. (2008). Trans-10, Cis-12 Conjugated Linoleic Acid Antagonizes Ligand-Dependent PPARγ Activity in Primary Cultures of Human Adipocytes. The Journal of Nutrition, 138(3), 455–461. https://doi.org/10.1093/jn/138.3.455

Chung, S., LaPoint, K., Martinez, K., Kennedy, A., Boysen Sandberg, M., & McIntosh, M. K. (2006). Preadipocytes Mediate Lipopolysaccharide-Induced Inflammation and Insulin Resistance in Primary Cultures of Newly Differentiated Human Adipocytes. Endocrinology, 147(11), 5340–5351. https://doi.org/10.1210/en.2006-0536

Freeman, L. A., Kennedy, A., Wu, J., Bark, S., Remaley, A. T., Santamarina-Fojo, S., & Brewer, H. B., Jr. (2004). The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter. Journal of Lipid Research, 45(7), 1197–1206. https://doi.org/10.1194/jlr.c400002-jlr200