Alexander K. Nguyen

Works (17)

Updated: July 13th, 2023 21:14

2022 article

Effect of simulated body fluid formulation on orthopedic device apatite-forming ability assessment

Nguyen, A. K. K., Nelson, S. B. B., Skoog, S. A. A., Jaipan, P., Petrochenko, P. E. E., Kaiser, A., … Kumar, G. (2022, November 29). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS.

By: A. Nguyen n, S. Nelson*, S. Skoog *, P. Jaipan n, P. Petrochenko*, A. Kaiser *, L. Lo *, J. Moreno* ...

MeSH headings : Humans; Apatites / chemistry; Calcium / chemistry; Surface Properties; Durapatite / chemistry; Body Fluids / chemistry; Microscopy, Electron, Scanning; X-Ray Diffraction
TL;DR: Evaluation of the effect of SBF formulation on bioactivity assessment revealed that SBF enriched with double or quadruple the calcium and phosphate ion concentrations increased hydroxyapatite crystal size and quantity compared to the standard formulation and can induce hydroxyAPatite crystallization on surfaces traditionally considered non-bioactive. (via Semantic Scholar)
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Added: December 19, 2022

2022 journal article

Micromolding of Amphotericin-B-Loaded Methoxyethylene-Maleic Anhydride Copolymer Microneedles

PHARMACEUTICS, 14(8).

By: S. Azizi Machekposhti n, A. Nguyen n, L. Vanderwal*, S. Stafslien* & R. Narayan n

author keywords: microneedles; amphotericin B; transdermal drug delivery; fungus
TL;DR: Amphotericin B GantrezTM microneedles fabricated in this study showed appropriate characteristics for clinical translation in terms of mechanical properties, sharpness, and antifungal properties. (via Semantic Scholar)
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Added: September 6, 2022

2021 review

Biological function following radical photo-polymerization of biomedical polymers and surrounding tissues: Design considerations and cellular risk factors

[Review of ]. APPLIED PHYSICS REVIEWS, 8(1).

By: G. Lindberg *, K. Lim *, B. Soliman *, A. Nguyen n, G. Hooper *, R. Narayan n, T. Woodfield *

TL;DR: Current and emerging toolkits to photo-polymerize biomedical polymers requiring the direct irradiation of cells and/or mammalian tissues and its associated impact on biological functionality are summarized. (via Semantic Scholar)
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Added: February 1, 2021

2021 article

Digital light processing-based 3D printing of polytetrafluoroethylene solid microneedle arrays

Sachan, R., Nguyen, A. K., Lu, J., Erdmann, D., Zhang, J. Y., & Narayan, R. J. (2021, November 9). MRS COMMUNICATIONS.

By: R. Sachan n, A. Nguyen n, J. Lu *, D. Erdmann *, J. Zhang * & R. Narayan n

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Added: November 23, 2021

2021 article

Direct ink writing of vancomycin-loaded polycaprolactone/ polyethylene oxide/ hydroxyapatite 3D scaffolds

Zhang, B., Nguyen, A. K., Narayan, R. J., & Huang, J. (2021, July 30). JOURNAL OF THE AMERICAN CERAMIC SOCIETY.

By: B. Zhang *, A. Nguyen n, R. Narayan n & J. Huang *

author keywords: bone tissue scaffold; bioceramics; direct ink writing; drug release; hydroxyapatite; ink rheology behavior; mechanical property; printing; processing
TL;DR: Novel drug-loaded PCL/PEO/HAp inks for 3D scaffold fabrication using the DIW printing technique for potential bone scaffold applications are presented. (via Semantic Scholar)
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Added: August 16, 2021

2020 journal article

Argon and oxygen plasma treatment increases hydrophilicity and reduces adhesion of silicon-incorporated diamond-like coatings

BIOINTERPHASES, 15(4).

By: S. Movahed n, A. Nguyen n, P. Goering  n, S. Skoog  n & R. Narayan n

MeSH headings : Animals; Argon / chemistry; Cell Adhesion / drug effects; Cell Line; Cell Survival / drug effects; Coated Materials, Biocompatible / chemical synthesis; Coated Materials, Biocompatible / chemistry; Coated Materials, Biocompatible / pharmacology; Diamond / chemistry; Hydrophobic and Hydrophilic Interactions; Mice; Microscopy, Atomic Force; Oxygen / chemistry; Photoelectron Spectroscopy; Plasma Gases / chemistry; Silicon / chemistry; Surface Properties
TL;DR: The suitability of Si-DLC coatings as inert coatings for medical and biotechnology applications is indicated by the results of the study. (via Semantic Scholar)
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Added: August 17, 2020

2020 journal article

Matrix-Assisted Pulsed laser Evaporation-deposited Rapamycin Thin Films Maintain Antiproliferative Activity

INTERNATIONAL JOURNAL OF BIOPRINTING, 6(1), 105–111.

By: R. Cristescu *, I. Negut, A. Visan *, A. Nguyen n, A. Sachan*, P. Goering *, D. Chrisey *, R. Narayan n

author keywords: Rapamycin; Drug delivery; Matrix-assisted pulsed laser evaporation; Thin film
TL;DR: Data indicate that the antiproliferative properties of rapamycin were maintained after MAPLE deposition, and the thickness of the coating that is applied to the surface of the medical device can be tightly controlled. (via Semantic Scholar)
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Added: February 27, 2020

2020 journal article

Physical characterization and in vitro evaluation of 3D printed hydroxyapatite, tricalcium phosphate, zirconia, alumina, and SiAlON structures made by lithographic ceramic manufacturing

MRS ADVANCES, 5(46-47), 2419–2428.

By: A. Nguyen n, P. Goering *, S. Skoog * & R. Narayan n

author keywords: biomaterial; additive manufacturing
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Added: November 2, 2020

2020 journal article

The Photoinitiator Lithium Phenyl (2,4,6-Trimethylbenzoyl) Phosphinate with Exposure to 405 nm Light Is Cytotoxic to Mammalian Cells but Not Mutagenic in Bacterial Reverse Mutation Assays

POLYMERS, 12(7).

By: A. Nguyen n, P. Goering *, R. Elespuru *, S. Das * & R. Narayan n

author keywords: lithium phenyl (2; 4; 6-trimethylbenzoyl) phosphinate; gelatin methacryloyl; bioprinting; photoinitiator; light exposure; mutagenicity; cytotoxicity; photorheology
TL;DR: The data indicate that the combination of LAP and free radicals generated from photo-excited LAP is cytotoxic, but mutagenicity was not observed in bacteria under typical bioprinting conditions. (via Semantic Scholar)
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Added: August 17, 2020

2019 journal article

Engineering Polymer-Binding Bispecific Antibodies for Enhanced Pretargeted Delivery of Nanoparticles to Mucus-Covered Epithelium

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58(17), 5604–5608.

By: J. Huckaby  n, C. Parker*, T. Jacobs *, A. Schaefer  n, D. Wadsworth *, A. Nguyen n, A. Wang  n, J. Newby *, S. Lai n

author keywords: antibodies; drug delivery; mucus; nanoparticles; PEGylation
MeSH headings : Antibodies, Bispecific / metabolism; Humans; Nanoparticles / metabolism; Polymers / metabolism
TL;DR: This work explored a two-step "pretargeting" approach through engineering a bispecific antibody that binds both cell-surface ICAM-1 and polyethylene glycol (PEG) on the surface of nanoparticles, thereby effectively decoupling cell targeting from particle design and formulation. (via Semantic Scholar)
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Added: June 4, 2019

2019 journal article

Microneedle-Based Delivery of Amphotericin B for Treatment of Cutaneous Leishmaniasis

BIOMEDICAL MICRODEVICES, 21(1).

By: A. Nguyen n, K. Yang n, K. Bryant*, J. Li *, A. Joice*, K. Werbovetz *, R. Narayan n

author keywords: Microneedle; Drug delivery; Amphotericin B; Leishmaniasis
MeSH headings : Amphotericin B / pharmacology; Animals; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Leishmania mexicana / metabolism; Leishmaniasis, Cutaneous / drug therapy; Leishmaniasis, Cutaneous / metabolism; Leishmaniasis, Cutaneous / pathology; Mice; Mice, Inbred BALB C; Needles
TL;DR: The results show the promise of topical delivery of amphotericin B via microneedles in treating relatively small nodules caused by L. mexicana and show the limitations of the approach against a disseminated L. major infection. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 21, 2019

2019 journal article

Sintered Tape-cast 3YSZ Supports Human Bone Marrow Derived Stem Cell Osteogenic Differentiation

MRS ADVANCES, 4(46-47), 2541–2549.

By: A. Nguyen n, P. Goering *, J. Olenick, K. Olenick & R. Narayan n

author keywords: biomaterial; ceramic; nano-indentation; bone
TL;DR: This method for producing a YSZ ceramic yields a typical material of this type and supports attachment and differentiation of hBMSC; thus, making it useful as a bone implant material. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
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Added: December 30, 2019

2019 journal article

Toxicity and photosensitizing assessment of gelatin methacryloyl-based hydrogels photoinitiated with lithium phenyl-2,4,6-trimethylbenzoylphosphinate in human primary renal proximal tubule epithelial cells

BIOINTERPHASES, 14(2).

By: A. Nguyen n, P. Goering  n, V. Reipa  n & R. Narayan n

MeSH headings : Biocompatible Materials / chemical synthesis; Biocompatible Materials / toxicity; Cell Survival / drug effects; Cells, Cultured; Elasticity; Epithelial Cells / drug effects; Gelatin / chemistry; Gelatin / toxicity; Humans; Hydrogels / chemical synthesis; Hydrogels / toxicity; Lithium / toxicity; Materials Testing; Phosphinic Acids / toxicity; Polyhydroxyethyl Methacrylate / chemical synthesis; Polyhydroxyethyl Methacrylate / toxicity; Tissue Scaffolds
TL;DR: Complete cross-linking of all formulations decreased photocatalytic activity while maintaining predictable final elastic moduli, and differences in cytotoxicity evaluation determined from the two viability assays imply cell membrane damage and should be investigated further. (via Semantic Scholar)
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Added: May 20, 2019

2018 article

3D Printing in the Biomedical Field

ENCYCLOPEDIA OF BIOMEDICAL ENGINEERING, VOL 2, pp. 275–280.

By: A. Nguyen n, R. Narayan n & A. Shafiee *

TL;DR: 3D printing encompasses multiple fabrication technologies and materials ranging from extrusion to laser processing, and materials such as live cells or metal powders can be processed for applications ranging from soft tissue to rigid prosthetics. (via Semantic Scholar)
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Added: March 30, 2020

2017 journal article

Two-photon polymerization for biological applications

MATERIALS TODAY, 20(6), 314–322.

By: A. Nguyen n & R. Narayan n

TL;DR: Current research into TPA-sensitive photopolymers with good biocompatibility and holographic projections using spatial light modulators address current technological limitations by providing materials specifically formulated for biological applications and by making better use of available laser power for applications in which nanoscale resolution is not required. (via Semantic Scholar)
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Added: August 6, 2018

2015 journal article

Osteogenic Differentiation of Human Mesenchymal Stem Cells in 3-D Zr-Si Organic-Inorganic Scaffolds Produced by Two-Photon Polymerization Technique

PLOS ONE, 10(2).

By: A. Koroleva *, A. Deiwick*, A. Nguyen n, S. Schlie-Wolter*, R. Narayan n, P. Timashev *, V. Popov, V. Bagratashvili, B. Chichkov *

MeSH headings : Adipose Tissue / cytology; Alkaline Phosphatase / metabolism; Calcium / metabolism; Cell Culture Techniques / methods; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chemistry Techniques, Synthetic / methods; Elastic Modulus; Hardness; Humans; Inorganic Chemicals / chemistry; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Mesenchymal Stem Cells / ultrastructure; Microscopy, Electron, Scanning; Organic Chemicals / chemistry; Osteocalcin / metabolism; Osteogenesis; Polymerization; Reproducibility of Results; Silicon / chemistry; Stem Cells / cytology; Stem Cells / metabolism; Stem Cells / ultrastructure; Time Factors; Tissue Engineering / methods; Tissue Scaffolds / chemistry; Zirconium / chemistry
TL;DR: Analysis of ALP activity, osteocalcin staining and SEM observations of matrix mineralization reveal that mesenchymal stem cells cultured on 3-D scaffolds without osteogenic stimulation spontaneously differentiate towards osteogenic lineage. (via Semantic Scholar)
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Added: August 6, 2018

2014 journal article

Two-photon polymerization of 3-D zirconium oxide hybrid scaffolds for long-term stem cell growth

BIOINTERPHASES, 9(2).

By: S. Skoog n, A. Nguyen n, G. Kumar*, J. Zheng *, P. Goering *, A. Koroleva *, B. Chichkov *, R. Narayan n

MeSH headings : Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Bone Marrow Cells / cytology; Cell Adhesion / drug effects; Cell Culture Techniques; Cell Proliferation / drug effects; Cells, Cultured; Humans; Mesenchymal Stem Cells / cytology; Methacrylates / chemistry; Photons; Polymerization; Silanes / chemistry; Zirconium / chemistry
TL;DR: It is indicated that two-photon polymerization may be used to create microstructured scaffolds out of an inorganic-organic zirconium oxide hybrid material for use in 3-D tissue culture systems. (via Semantic Scholar)
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Added: August 6, 2018

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