Arun Varghese Kolanjiyil

Works (8)

Updated: July 17th, 2023 09:00

2019 journal article

Modeling Airflow and Particle Deposition in a Human Acinar Region

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2019.

By: A. Kolanjiyil n & C. Kleinstreuer n

MeSH headings : Acinar Cells / physiology; Computer Simulation; Humans; Imaging, Three-Dimensional; Models, Anatomic; Models, Biological; Particulate Matter / pharmacokinetics; Pulmonary Alveoli / anatomy & histology; Pulmonary Alveoli / physiology; Respiration; Respiratory Mechanics / physiology
TL;DR: A physiologically inspired whole acinar model has been developed that can be readily incorporated into human whole-lung airway models to simulate/predict the flow dynamics of toxic or therapeutic aerosols. (via Semantic Scholar)
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Added: February 11, 2019

2018 journal article

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94.

By: A. Kolanjiyil n, C. Kleinstreuer n, N. Kleinstreuer *, W. Pham * & R. Sadikot *

author keywords: Lung deposition; Mouse lung model; Human lung model; Dose extrapolation; Pharmacokinetics
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Animals; Computer Simulation; Female; Humans; Hydrodynamics; Lung / anatomy & histology; Lung / physiology; Male; Mice; Models, Biological; Pulmonary Ventilation / physiology
TL;DR: The presented computer simulation models provide detailed fluid-particle dynamics results for upper lung airways of representative human and mouse models with a comparative analysis of particle lung deposition data, including a novel mice-to-men correlation as well as a particle-clearance analysis both useful for pharmacokinetic and toxicokinetic studies. (via Semantic Scholar)
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Added: February 11, 2019

2017 journal article

Computational analysis of aerosol-dynamics in a human whole-lung airway model

JOURNAL OF AEROSOL SCIENCE, 114, 301–316.

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: Whole-lung airway model; Particle deposition; Lung air-particle dynamics; Local and total lung depositions; Actual breathing modes; Alveolar region
TL;DR: The new whole-lung airway model (WLAM) can be used for local, segmental and total deposition predictions of inhaled toxic or therapeutic aerosols, and for providing inhaler-design guidelines to improve drug-aerosol targeting. (via Semantic Scholar)
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Added: August 6, 2018

2017 journal article

Subject-variability effects on micron particle deposition in human nasal cavities

JOURNAL OF AEROSOL SCIENCE, 115, 12–28.

By: H. Calmet *, C. Kleinstreuer n, G. Houzeaux *, A. Kolanjiyil n, O. Lehmkuhl *, E. Olivares *, M. Vazquez *

author keywords: Nasal cavities; Particle transport/deposition; Computational fluid-particle dynamics
TL;DR: Computer simulations of the airflow and particle dynamics in human nasal cavities are important for local, segmental and total deposition predictions of both inhaled toxic and therapeutic particles, and a new dimensionless group with which total particle deposition efficiency curves are very similar for all airway models is developed. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation

COMPUTERS IN BIOLOGY AND MEDICINE, 79, 193–204.

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: Lung; Airflow; Whole lung airway modeling; Computational fluid dynamics; Particle deposition
MeSH headings : Computational Biology; Computer Simulation; Humans; Hydrodynamics; Lung / physiology; Models, Biological; Respiratory Mechanics / physiology; Respiratory Transport / physiology; Trachea / physiology
TL;DR: The present new whole-lung-airway model (WLAM) represents the actual lung geometry via a basic 3-D mouth-to-trachea configuration while all subsequent airways are lumped together, i.e., reduced to an exponentially expanding 1-D conduit. (via Semantic Scholar)
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Added: August 6, 2018

2016 journal article

Laminar/turbulent airflow and microsphere deposition in a patient-specific airway geometry using an open-source solver

INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, 22(2), 145–161.

By: M. Vaish n, C. Kleinstreuer n, A. Kolanjiyil n, N. Saini n & N. Pillalamarri*

author keywords: OpenFOAM solver; patient-specific geometry and idealised configuration; modified eddy interaction model; microsphere transport and deposition; practical Stokes number range
TL;DR: Using the open-source software OpenFOAM as the solver, airflow and microsphere transport have been simulated in a patient-specific lung-airway model and results indicate that selection of an appropriate near-wall correction factor can reduce the problem of subject variability for different lung- airway configurations. (via Semantic Scholar)
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Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part I: Whole-Lung Aerosol Dynamics

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: computational fluid-particle dynamics; multicompartment modeling; nanoparticle kinetics; nanoparticle deposition; toxic nanoparticles; nanodrugs
MeSH headings : Aerosols; Humans; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles / chemistry; Particle Size; Pulmonary Alveoli / metabolism; Reproducibility of Results; Tissue Distribution
TL;DR: Combining high-resolution computer simulation results of inhaled NP deposition in the human airways with a multicompartmental model for NP-mass transfer allows for the prediction of temporal NP accumulation in the blood and lymphatic systems as well as in organs. (via Semantic Scholar)
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Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part II: Multi-Compartmental Modeling

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: multicompartment modeling; animal test data; model validations; nanoparticle bio-kinetics; temporal accumulations; human organs
MeSH headings : Animals; Body Weight; Humans; Hydrodynamics; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles; Organ Specificity; Rats; Tissue Distribution
TL;DR: High-resolution computer simulation results of inhaled nanoparticle deposition in a human airway model with a new multicompartmental model for insoluble nanoparticle barrier mass transfer into systemic regions provide critical insight into nanomaterial deposition and distribution from the lungs to systemic regions. (via Semantic Scholar)
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Added: August 6, 2018

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