Arun Varghese Kolanjiyil

Works (8)

Updated: July 17th, 2023 09:00

2019 journal article

Mice-to-men comparison of inhaled drug-aerosol deposition and clearance

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 260, 82–94.

By: A. Kolanjiyil n, C. Kleinstreuer n, N. Kleinstreuer*, W. Pham * & R. Sadikot *

author keywords: Lung deposition; Mouse lung model; Human lung model; Dose extrapolation; Pharmacokinetics
MeSH headings : Administration, Inhalation; Aerosols / administration & dosage; Animals; Computer Simulation; Female; Humans; Hydrodynamics; Lung / anatomy & histology; Lung / physiology; Male; Mice; Models, Biological; Pulmonary Ventilation / physiology
TL;DR: The presented computer simulation models provide detailed fluid-particle dynamics results for upper lung airways of representative human and mouse models with a comparative analysis of particle lung deposition data, including a novel mice-to-men correlation as well as a particle-clearance analysis both useful for pharmacokinetic and toxicokinetic studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 11, 2019

2019 journal article

Modeling Airflow and Particle Deposition in a Human Acinar Region

COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2019.

By: A. Kolanjiyil n & C. Kleinstreuer n

MeSH headings : Acinar Cells / physiology; Computer Simulation; Humans; Imaging, Three-Dimensional; Models, Anatomic; Models, Biological; Particulate Matter / pharmacokinetics; Pulmonary Alveoli / anatomy & histology; Pulmonary Alveoli / physiology; Respiration; Respiratory Mechanics / physiology
TL;DR: A physiologically inspired whole acinar model has been developed that can be readily incorporated into human whole-lung airway models to simulate/predict the flow dynamics of toxic or therapeutic aerosols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 11, 2019

2018 journal article

Subject-variability effects on micron particle deposition in human nasal cavities

JOURNAL OF AEROSOL SCIENCE, 115, 12–28.

By: H. Calmet *, C. Kleinstreuer n, G. Houzeaux *, A. Kolanjiyil n, O. Lehmkuhl *, E. Olivares*, M. Vazquez *

author keywords: Nasal cavities; Particle transport/deposition; Computational fluid-particle dynamics
TL;DR: Computer simulations of the airflow and particle dynamics in human nasal cavities are important for local, segmental and total deposition predictions of both inhaled toxic and therapeutic particles, and a new dimensionless group with which total particle deposition efficiency curves are very similar for all airway models is developed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Computational analysis of aerosol-dynamics in a human whole-lung airway model

JOURNAL OF AEROSOL SCIENCE, 114, 301–316.

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: Whole-lung airway model; Particle deposition; Lung air-particle dynamics; Local and total lung depositions; Actual breathing modes; Alveolar region
TL;DR: The new whole-lung airway model (WLAM) can be used for local, segmental and total deposition predictions of inhaled toxic or therapeutic aerosols, and for providing inhaler-design guidelines to improve drug-aerosol targeting. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Computationally efficient analysis of particle transport and deposition in a human whole-lung-airway model. Part I: Theory and model validation

COMPUTERS IN BIOLOGY AND MEDICINE, 79, 193–204.

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: Lung; Airflow; Whole lung airway modeling; Computational fluid dynamics; Particle deposition
MeSH headings : Computational Biology; Computer Simulation; Humans; Hydrodynamics; Lung / physiology; Models, Biological; Respiratory Mechanics / physiology; Respiratory Transport / physiology; Trachea / physiology
TL;DR: The present new whole-lung-airway model (WLAM) represents the actual lung geometry via a basic 3-D mouth-to-trachea configuration while all subsequent airways are lumped together, i.e., reduced to an exponentially expanding 1-D conduit. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Laminar/turbulent airflow and microsphere deposition in a patient-specific airway geometry using an open-source solver

INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING AND TECHNOLOGY, 22(2), 145–161.

By: M. Vaish n, C. Kleinstreuer n, A. Kolanjiyil n, N. Saini n & N. Pillalamarri*

author keywords: OpenFOAM solver; patient-specific geometry and idealised configuration; modified eddy interaction model; microsphere transport and deposition; practical Stokes number range
TL;DR: Using the open-source software OpenFOAM as the solver, airflow and microsphere transport have been simulated in a patient-specific lung-airway model and results indicate that selection of an appropriate near-wall correction factor can reduce the problem of subject variability for different lung- airway configurations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part I: Whole-Lung Aerosol Dynamics

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: computational fluid-particle dynamics; multicompartment modeling; nanoparticle kinetics; nanoparticle deposition; toxic nanoparticles; nanodrugs
MeSH headings : Aerosols; Humans; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles / chemistry; Particle Size; Pulmonary Alveoli / metabolism; Reproducibility of Results; Tissue Distribution
TL;DR: Combining high-resolution computer simulation results of inhaled NP deposition in the human airways with a multicompartmental model for NP-mass transfer allows for the prediction of temporal NP accumulation in the blood and lymphatic systems as well as in organs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part II: Multi-Compartmental Modeling

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 135(12).

By: A. Kolanjiyil n & C. Kleinstreuer n

author keywords: multicompartment modeling; animal test data; model validations; nanoparticle bio-kinetics; temporal accumulations; human organs
MeSH headings : Animals; Body Weight; Humans; Hydrodynamics; Inhalation; Lung / metabolism; Lung / physiology; Models, Biological; Nanoparticles; Organ Specificity; Rats; Tissue Distribution
TL;DR: High-resolution computer simulation results of inhaled nanoparticle deposition in a human airway model with a new multicompartmental model for insoluble nanoparticle barrier mass transfer into systemic regions provide critical insight into nanomaterial deposition and distribution from the lungs to systemic regions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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