Works (2)
Updated: July 5th, 2023 15:42
2021 journal article
Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring
VETERINARY MICROBIOLOGY, 254.
author keywords: Staphylococcus pseudintermedius; Antimicrobial resistance; Genomics
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Canada; Dog Diseases / microbiology; Dogs / microbiology; Drug Resistance, Bacterial / genetics; Epidemiological Monitoring / veterinary; Genomics / methods; Genomics / standards; Genotype; Microbial Sensitivity Tests; Phenotype; Phylogeny; Reproducibility of Results; Staphylococcal Infections / microbiology; Staphylococcal Infections / veterinary; Staphylococcus / drug effects; Staphylococcus / genetics; Staphylococcus / isolation & purification; United States; Whole Genome Sequencing
TL;DR:
The results show the value in using WGS to assess antimicrobial resistance in veterinary pathogens and to reveal putative new mechanisms of resistance, as well as identifying a novel rpoB mutation likely encoding rifampin resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 19, 2021
2014 journal article
Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens
JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458.
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / drug effects; Hemolysis / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microbial Sensitivity Tests; Sheep; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects
TL;DR:
A small molecule was identified from this library of aryl amide 2-aminoimidazoles that is capable of lowering the minimum inhibitory concentration of β-lactam antibiotics by up to 64-fold.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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