Aparna Krishnamurthy

Works (2)

Updated: July 5th, 2023 15:42

2021 journal article

Genomics accurately predicts antimicrobial resistance in Staphylococcus pseudintermedius collected as part of Vet-LIRN resistance monitoring

VETERINARY MICROBIOLOGY, 254.

By: G. Tyson *, O. Ceric *, J. Guag*, S. Nemser *, S. Borenstein*, D. Slavic*, S. Lippert*, R. McDowell* ...

author keywords: Staphylococcus pseudintermedius; Antimicrobial resistance; Genomics
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Canada; Dog Diseases / microbiology; Dogs / microbiology; Drug Resistance, Bacterial / genetics; Epidemiological Monitoring / veterinary; Genomics / methods; Genomics / standards; Genotype; Microbial Sensitivity Tests; Phenotype; Phylogeny; Reproducibility of Results; Staphylococcal Infections / microbiology; Staphylococcal Infections / veterinary; Staphylococcus / drug effects; Staphylococcus / genetics; Staphylococcus / isolation & purification; United States; Whole Genome Sequencing
TL;DR: The results show the value in using WGS to assess antimicrobial resistance in veterinary pathogens and to reveal putative new mechanisms of resistance, as well as identifying a novel rpoB mutation likely encoding rifampin resistance. (via Semantic Scholar)
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Source: Web Of Science
Added: April 19, 2021

2014 journal article

Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458.

By: C. Brackett n, R. Melander n, I. An n, A. Krishnamurthy n, R. Thompson n, J. Cavanagh n, C. Melander n

MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / drug effects; Hemolysis / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microbial Sensitivity Tests; Sheep; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects
TL;DR: A small molecule was identified from this library of aryl amide 2-aminoimidazoles that is capable of lowering the minimum inhibitory concentration of β-lactam antibiotics by up to 64-fold. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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