@article{simpson_krissanaprasit_chester_koehler_labean_brown_2024, title={Utilizing multiscale engineered biomaterials to examine TGF-β-mediated myofibroblastic differentiation}, ISSN={["1524-475X"]}, DOI={10.1111/wrr.13168}, abstractNote={Abstract}, journal={WOUND REPAIR AND REGENERATION}, author={Simpson, Aryssa and Krissanaprasit, Abhichart and Chester, Daniel and Koehler, Cynthia and Labean, Thomas H. and Brown, Ashley C.}, year={2024}, month={Mar} } @article{hosseini_rahmanian_pirzada_frick_krissanaprasit_khan_labean_2022, title={DNA aerogels and DNA-wrapped CNT aerogels for neuromorphic applications}, volume={16}, ISSN={["2590-0064"]}, url={https://doi.org/10.1016/j.mtbio.2022.100440}, DOI={10.1016/j.mtbio.2022.100440}, abstractNote={Nucleic acids are programmable materials that can self-assemble into defined or stochastic three-dimensional network architectures. Various attributes of self-assembled, cross-linked Deoxyribonucleic acid (DNA) hydrogels have recently been investigated, including their mechanical properties and potential biomedical functions. Herein, for the first time, we describe the successful construction of pure DNA aerogels and DNA-wrapped carbon nanotube (CNT) composite (DNA-CNT) aerogels via a single-step freeze-drying of the respective hydrogels. These aerogels reveal highly porous and randomly branched structures with low density. The electrical properties of pure DNA aerogel mimic that of a simple capacitor; in contrast, the DNA-CNT aerogel displays a fascinating resistive switching behavior in response to an applied bias voltage sweep reminiscent of a volatile memristor. We believe these novel aerogels can serve as a platform for developing complex biomimetic devices for a wide range of applications, including real-time computation, neuromorphic computing, biochemical sensing, and biodegradable functional implants. More importantly, insight obtained here on self-assembling DNA to create aerogels will pave the way to construct novel aerogel-based material platforms from DNA coated or wrapped functional entities.}, journal={MATERIALS TODAY BIO}, author={Hosseini, Mahshid and Rahmanian, Vahid and Pirzada, Tahira and Frick, Nikolay and Krissanaprasit, Abhichart and Khan, Saad A. and LaBean, Thomas H.}, year={2022}, month={Dec} } @article{gao_krissanaprasit_miles_hsiao_labean_2021, title={Mechanical and Electrical Properties of DNA Hydrogel-Based Composites Containing Self-Assembled Three-Dimensional Nanocircuits}, volume={11}, ISSN={["2076-3417"]}, url={https://doi.org/10.3390/app11052245}, DOI={10.3390/app11052245}, abstractNote={Molecular self-assembly of DNA has been developed as an effective construction strategy for building complex materials. Among them, DNA hydrogels are known for their simple fabrication process and their tunable properties. In this study, we have engineered, built, and characterized a variety of pure DNA hydrogels using DNA tile-based crosslinkers and different sizes of linear DNA spacers, as well as DNA hydrogel/nanomaterial composites using DNA/nanomaterial conjugates with carbon nanotubes and gold nanoparticles as crosslinkers. We demonstrate the ability of this system to self-assemble into three-dimensional percolating networks when carbon nanotubes and gold nanoparticles are incorporated into the DNA hydrogel. These hydrogel composites showed interesting non-linear electrical properties. We also demonstrate the tuning of rheological properties of hydrogel-based composites using different types of crosslinkers and spacers. The viscoelasticity of DNA hydrogels is shown to dramatically increase by the use of a combination of interlocking DNA tiles and DNA/carbon nanotube crosslinkers. Finally, we present measurements and discuss electrically conductive nanomaterials for applications in nanoelectronics.}, number={5}, journal={APPLIED SCIENCES-BASEL}, author={Gao, Ming and Krissanaprasit, Abhichart and Miles, Austin and Hsiao, Lilian C. and LaBean, Thomas H.}, year={2021}, month={Mar} } @article{krissanaprasit_key_froehlich_pontula_mihalko_dupont_andersen_kjems_brown_labean_2021, title={Multivalent Aptamer-Functionalized Single-Strand RNA Origami as Effective, Target-Specific Anticoagulants with Corresponding Reversal Agents}, ISSN={["2192-2659"]}, DOI={10.1002/adhm.202001826}, abstractNote={Abstract}, journal={ADVANCED HEALTHCARE MATERIALS}, author={Krissanaprasit, Abhichart and Key, Carson M. and Froehlich, Kristen and Pontula, Sahil and Mihalko, Emily and Dupont, Daniel M. and Andersen, Ebbe S. and Kjems, Jorgen and Brown, Ashley C. and LaBean, Thomas H.}, year={2021}, month={Apr} } @misc{krissanaprasit_key_pontula_labean_2021, title={Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers}, volume={121}, ISSN={["1520-6890"]}, DOI={10.1021/acs.chemrev.0c01332}, abstractNote={Researchers have worked for many decades to master the rules of biomolecular design that would allow artificial biopolymer complexes to self-assemble and function similarly to the diverse biochemical constructs displayed in natural biological systems. The rules of nucleic acid assembly (dominated by Watson-Crick base-pairing) have been less difficult to understand and manipulate than the more complicated rules of protein folding. Therefore, nucleic acid nanotechnology has advanced more quickly than de novo protein design, and recent years have seen amazing progress in DNA and RNA design. By combining structural motifs with aptamers that act as affinity handles and add powerful molecular recognition capabilities, nucleic acid-based self-assemblies represent a diverse toolbox for use by bioengineers to create molecules with potentially revolutionary biological activities. In this review, we focus on the development of self-assembling nucleic acid nanostructures that are functionalized with nucleic acid aptamers and their great potential in wide ranging application areas.}, number={22}, journal={CHEMICAL REVIEWS}, author={Krissanaprasit, Abhichart and Key, Carson M. and Pontula, Sahil and LaBean, Thomas H.}, year={2021}, month={Nov}, pages={13797–13868} } @article{krissanaprasit_key_fergione_froehlich_pontula_hart_carriel_kjems_andersen_labean_2019, title={Genetically Encoded, Functional Single-Strand RNA Origami: Anticoagulant}, volume={31}, ISSN={["1521-4095"]}, DOI={10.1002/adma.201808262}, abstractNote={Abstract}, number={21}, journal={ADVANCED MATERIALS}, author={Krissanaprasit, Abhichart and Key, Carson and Fergione, Michael and Froehlich, Kristen and Pontula, Sahil and Hart, Matthew and Carriel, Pedro and Kjems, Jorgen and Andersen, Ebbe Sloth and LaBean, Thomas H.}, year={2019}, month={May} } @article{gudnason_madsen_krissanaprasit_gothelf_birkedal_2018, title={Controlled aggregation of DNA functionalized poly(phenylene-vinylene)}, volume={54}, ISSN={["1364-548X"]}, DOI={10.1039/c8cc00943k}, abstractNote={We show that aggregation of DNA-functionalized poly(phenylene-vinylene) can be controlled in solution through ion and DNA interactions.}, number={44}, journal={CHEMICAL COMMUNICATIONS}, author={Gudnason, Daniel and Madsen, Mikael and Krissanaprasit, Abhichart and Gothelf, Kurt V. and Birkedal, Victoria}, year={2018}, month={Jun}, pages={5534–5537} } @article{ouyang_de stefano_krissanaprasit_kodal_rosen_liu_helmig_fan_gothelf_2017, title={Docking of Antibodies into the Cavities of DNA Origami Structures}, volume={56}, ISSN={["1521-3773"]}, DOI={10.1002/anie.201706765}, abstractNote={Abstract}, number={46}, journal={ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, author={Ouyang, Xiangyuan and De Stefano, Mattia and Krissanaprasit, Abhichart and Kodal, Anne Louise Bank and Rosen, Christian Bech and Liu, Tianqiang and Helmig, Sarah and Fan, Chunhai and Gothelf, Kurt V.}, year={2017}, month={Nov}, pages={14423–14427} } @article{madsen_christensen_krissanaprasit_bakke_riber_nielsen_zelikin_gothelf_2017, title={Preparation, Single-Molecule Manipulation, and Energy Transfer Investigation of a Polyfluorene-graft-DNA polymer}, volume={23}, ISSN={["1521-3765"]}, DOI={10.1002/chem.201702780}, abstractNote={Abstract}, number={44}, journal={CHEMISTRY-A EUROPEAN JOURNAL}, author={Madsen, Mikael and Christensen, Rasmus S. and Krissanaprasit, Abhichart and Bakke, Mette R. and Riber, Camilla F. and Nielsen, Karina S. and Zelikin, Alexander N. and Gothelf, Kurt V.}, year={2017}, month={Aug}, pages={10511–10515} }