Anil K. Sharma

Works (3)

Updated: July 5th, 2023 15:55

2011 journal article

A bifunctional allosteric site in the dimer interface of procaspase-3

BIOPHYSICAL CHEMISTRY, 159(1), 100–109.

By: J. Schipper n, S. MacKenzie n, A. Sharma n & A. Clark n

author keywords: Caspase; Apoptosis; Allosteric activator; Drug design; Cancer therapy
MeSH headings : Allosteric Site; Caspase 3 / chemistry; Caspase 3 / metabolism; Enzyme Activation / drug effects; Humans; Models, Molecular; Protein Binding; Protein Multimerization; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
TL;DR: This work has utilized the allosteric site of caspase-3 to identify a small molecule activator of procaspase and to characterize its binding to the protease, and suggests that an efficient activator must stabilize the active conformer of the zymogen by expelling the intersubunit linker from the interface. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Dendritically Encapsulated, Water-Soluble Fe4S4: Synthesis and Electrochemical Properties

INORGANIC CHEMISTRY, 49(11), 5072–5078.

By: A. Sharma n, N. Kim n, C. Cameron n, M. Lyndon n & C. Gorman n 

Contributors: A. Sharma n, N. Kim n, C. Cameron n, M. Lyndon n & C. Gorman n 

TL;DR: A slower rate of heterogeneous electron transfer was found when these molecules were compared with non-amphiphilic analogues and this behavior is consistent with the idea that the dendrimers encapsulate the cluster to some degree, creating a hydrophobic microenvironment around the cluster. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2006 journal article

Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions

TETRAHEDRON, 63(2), 389–395.

By: A. Sharma n, A. Subramani n & C. Gorman n 

Contributors: A. Sharma n, A. Subramani n & C. Gorman n 

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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