@article{schipper_mackenzie_sharma_clark_2011, title={A bifunctional allosteric site in the dimer interface of procaspase-3}, volume={159}, ISSN={["1873-4200"]}, DOI={10.1016/j.bpc.2011.05.013}, abstractNote={The dimer interface of caspase-3 contains a bifunctional allosteric site in which the enzyme can be activated or inactivated, depending on the context of the protein. In the mature caspase-3, the binding of allosteric inhibitors to the interface results in an order-to-disorder transition in the active site loops. In procaspase-3, by contrast, the binding of allosteric activators to the interface results in a disorder-to-order transition in the active site. We have utilized the allosteric site to identify a small molecule activator of procaspase and to characterize its binding to the protease. The data suggest that an efficient activator must stabilize the active conformer of the zymogen by expelling the intersubunit linker from the interface, and it must interact with active site residues found in the allosteric site. Small molecule activators that fulfill the two requirements should provide scaffolds for drug candidates as a therapeutic strategy for directly promoting procaspase-3 activation in cancer cells.}, number={1}, journal={BIOPHYSICAL CHEMISTRY}, author={Schipper, Joshua L. and MacKenzie, Sarah H. and Sharma, Anil and Clark, A. Clay}, year={2011}, month={Nov}, pages={100–109} }
 @article{sharma_kim_cameron_lyndon_gorman_2010, title={Dendritically Encapsulated, Water-Soluble Fe4S4: Synthesis and Electrochemical Properties}, volume={49}, ISSN={["0020-1669"]}, DOI={10.1021/ic1002447}, abstractNote={Amphiphilic, Fe(4)S(4) cluster core dendrimers can be prepared via ligand exchange with dendrons containing carboxylic acid peripheral groups and a thiol focal group. These amphiphilic dendrons are more susceptible to oxidative disulfide formation than their non-amphiphilic analogues reported previously. Thus, an in situ deprotection of an aromatic thioacetate was necessary to prepare the dendrimers. These molecules showed the expected decrease in rate with increasing generation. A slower rate of heterogeneous electron transfer was found when these molecules were compared with non-amphiphilic analogues. This behavior correlated with their larger size and thus a larger effective distance of electron transfer. Voltammetry in DMSO with added water makes the dendrimers easier to reduce, but the change in redox potential is much smaller for all dendrimers when compared to a non-dendritic analogue. This behavior is consistent with the idea that the dendrimers encapsulate the cluster to some degree, creating a hydrophobic microenvironment around the cluster.}, number={11}, journal={INORGANIC CHEMISTRY}, author={Sharma, Anil K. and Kim, Namjin and Cameron, Christopher S. and Lyndon, Matthew and Gorman, Christopher B.}, year={2010}, month={Jun}, pages={5072–5078} }
 @article{sharma_subramani_gorman_2007, title={Efficient synthesis of halo indanones via chlorosulfonic acid mediated Friedel-Crafts cyclization of aryl propionic acids and their use in alkylation reactions}, volume={63}, ISSN={["0040-4020"]}, DOI={10.1016/j.tet.2006.10.065}, abstractNote={Several halo indanones were synthesized from benzyl Meldrum's acid derivatives in two steps. Although several Lewis acids are effective for the Friedel–Crafts ring-closing reaction on more electron-rich arenes, in the case of the electron-deficient arenes this chemistry is not efficient. Here it is reported that chlorosulfonic acid (used as solvent) is an efficient reagent for cyclization of electron-withdrawing arenes. These molecules are potentially useful for subsequent alkylation reactions. The selective alkylation of 5,7-dibromo indanone is demonstrated using Pd-catalyzed Grignard coupling to provide monoalkylated indanone in good yield.}, number={2}, journal={TETRAHEDRON}, author={Sharma, Anil K. and Subramani, Amutha V. and Gorman, Christopher B.}, year={2007}, month={Jan}, pages={389–395} }