Works (8)

Updated: April 5th, 2024 12:25

2024 journal article

TL;DR: R reverse metabolomics is presented as a discovery strategy, whereby tandem mass spectrometry spectra acquired from newly synthesized compounds are searched for in public metabolomics datasets to uncover phenotypic associations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: March 4, 2024

2023 article

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY, Vol. 3.

By: M. Foley n, M. Walker*, A. Stewart n, S. O'Flaherty n, E. Gentry*, S. Patel*, V. Beaty*, G. Allen n ...

MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
TL;DR: Insight is provided into the structural basis of BSH mechanisms that shape the BA landscape and promote colonization resistance against C. difficile in vitro and in pre-clinical in vivo models of CDI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2023 journal article

Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems

ANALYTICAL CHEMISTRY, 95(41), 15357–15366.

By: A. Stewart n, M. Foley n, M. Dougherty*, S. Mcgill*, A. Gulati*, E. Gentry*, L. Hagey*, P. Dorrestein* ...

TL;DR: This work analyzed 8 core bile acids synthetically conjugated with 22 proteinogenic and nonproteogenic amino acids totaling 176 MCBAs and created an in-house extended bile acid library that was applied to healthy mice dosed with antibiotics and humans having fecal microbiota transplantation (FMT) to assess the MCBA presence and changes in the gut before and after each perturbation. (via Semantic Scholar)
Source: Web Of Science
Added: October 30, 2023

2022 article

Assessing the Fate of Dissolved Organic Compounds in Landfill Leachate and Wastewater Treatment Systems

Doyle, M. G., Odenkirk, M. T., Stewart, A. K., Nelson, J. P., Baker, E. S., & Cruz, F. (2022, November 1). ACS ES&T WATER, Vol. 11.

By: M. Doyle n, M. Odenkirk n, A. Stewart n, J. Nelson n, E. Baker n & F. Cruz n

author keywords: nontargeted analysis; anthropogenic chemicals; wastewater; landfill leachate; reverse osmosis
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 2, 2022

2022 journal article

Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para-aminobenzoate in Chlamydia trachomatis


By: O. Manley n, H. Phan n, A. Stewart n, D. Mosley n, S. Xue*, L. Cha n, H. Bai n, V. Lightfoot* ...

Contributors: T. Williams n

author keywords: folate biosynthesis; radical transfer; spectroscopy; heterobinuclear cluster
MeSH headings : Bacterial Proteins / metabolism; Chlamydia trachomatis / enzymology; Folic Acid; Iron / metabolism; Manganese / metabolism; Oxygen / metabolism; Oxygenases / metabolism; Tyrosine / metabolism; para-Aminobenzoates / metabolism
TL;DR: High in vitro activity relies on the stoichiometric addition of both Fe and Mn, and CADD is shown to activate O2 to self-sacrificially produce pABA from Tyr27. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 21, 2022

2021 journal article

Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses


author keywords: Antiviral; Venezuelan equine encephalitis virus; Eastern equine encephalitis virus; Marine microbe; Drug development; Therapeutic
MeSH headings : Actinobacteria / chemistry; Animals; Antiviral Agents / pharmacology; Aquatic Organisms / chemistry; Cell Line; Chlorocebus aethiops; Encephalitis Virus, Eastern Equine / drug effects; Encephalitis Virus, Venezuelan Equine / drug effects; Fluorenes / pharmacology; Humans; Vero Cells; Virus Replication / drug effects
TL;DR: It is demonstrated that homoseongomycin is a potential anti-VEEV and anti-EEEV compound due to its low cytotoxicity and potent antiviral activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: July 12, 2021

2021 journal article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization


By: M. Foley n, S. O'Flaherty n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n, C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
TL;DR: It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2021

2020 journal article

Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain


By: K. Rock n, G. St Armour n, B. Horman n, A. Phillips*, M. Ruis*, A. Stewart n, D. Jima n, D. Muddiman n, H. Stapleton*, H. Patisaul n

author keywords: endocrine disruptors; endocrine toxicology; flame retardants; metabolome; neurotoxicity; developmental; neurotoxicology; neurotransmitter; developmental toxicity; prenatal; reproductive and developmental toxicology; developmental/teratology
MeSH headings : Animals; Brain / drug effects; Female; Fetal Development; Fetus; Flame Retardants / toxicity; Gene Expression; Humans; Male; Organophosphates; Organophosphorus Compounds; Placenta / metabolism; Plasticizers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin / metabolism
TL;DR: Findings suggest that OPFRs have the potential to impact the 5-HTergic system in the fetal forebrain by disrupting placental Trp metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 14, 2020

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