Aneg L Cortes

Works (30)

Updated: April 8th, 2024 08:24

2024 article

Evaluation of Adjuvant Effect of Cytosine-Guanosine-Oligodeoxynucleotide in Meat-Type Chickens Coadministered <i>In Ovo</i> with Herpesvirus of Turkey Vaccine

Boone, A. C., Kulkarni, R. R., Cortes, A. L., Gaghan, C., Mohammed, J., Villalobos, T., … Gimeno, I. M. (2024, February 1). VIRAL IMMUNOLOGY, Vol. 2.

By: A. Boone n, R. Kulkarni  n, A. Cortes n, C. Gaghan n, J. Mohammed*, T. Villalobos*, J. Esandi*, I. Gimeno n 

author keywords: herpesvirus of turkey; toll-like receptor 21; cellular immunity; immunocompetence; in ovo vaccination; chickens
TL;DR: Adding cytosine-guanosine oligodeoxynucleotides (CpG ODNs) to the HVT vaccine could enhance the adjuvant effect of HVT, and CpG ODN administration in ovo with or without HVT significantly increased frequencies of activated CD4+ and CD8+ T cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2024

2024 article

Optimizing protocols for monitoring <i>in vivo</i> replication of a novel chimeric Marek's disease vaccine with an insertion of the long terminal repeat of reticuloendotheliosis virus in the CVI988 strain genome (CVI-LTR)

Faiz, N. M., Cortes, A. L., Phang, Y.-fun, & Gimeno, I. M. (2024, March 21). AVIAN PATHOLOGY, Vol. 3.

By: N. Faiz*, A. Cortes n, Y. Phang & I. Gimeno n 

author keywords: Marek's disease; vaccines; monitoring; feather pulp; lymphoid organs; LTR
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2023 journal article

Effect of CpG-Oligonucleotide in Enhancing Recombinant Herpes Virus of Turkey-Laryngotracheitis Vaccine-Induced Immune Responses in One-Day-Old Broiler Chickens

VACCINES, 11(2).

By: C. Gaghan n, M. Browning n, A. Cortes n, I. Gimeno n  & R. Kulkarni  n

author keywords: infectious laryngotracheitis; CpG-ODN; adjuvant; immune response; chickens
TL;DR: Findings suggested that CpG-ODN can boost rHVT-LT-induced immune responses in day-old chicks, which may help in anti-ILT defense during their later stages of life. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 31, 2023

2023 journal article

In ovo HVT vaccination enhances cellular responses at hatch and addition of poly I:C offers minimal adjuvant effects

VACCINE, 41(15), 2514–2523.

By: A. Boone n, R. Kulkarni  n, A. Cortes n, T. Villalobos*, J. Esandi* & I. Gimeno n 

author keywords: Herpesvirus of turkey; Toll -like receptor 3; Innate and Cellular immunity; Immunocompetence; In ovo vaccination; Chickens
MeSH headings : Animals; Chickens; Poly I-C / pharmacology; Toll-Like Receptor 3; Interleukin-13; CD28 Antigens; Marek Disease; Herpesvirus 1, Meleagrid; Interferon-gamma; Vaccination / veterinary
TL;DR: The cellular mechanisms by which HVT-RD can hasten immunocompetence in one-day-old meat-type chickens are evaluated, and it is determined if HVT adjuvantation with a TLR3 agonist, polyinosinic-polycytidylic acid (poly(I:C)), could enhance vaccine-induced responses and provide dose-sparing effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 8, 2023

2021 article

Characterization of Md5-BAC-REV-LTR virus as Marek's disease vaccine in commercial meat-type chickens: protection and immunosuppression

Ellington, C., Cortes, A. L., Faiz, N. M., Mays, J. K., Fadly, A., Silva, R. F., & Gimeno, I. M. (2021, October 9). AVIAN PATHOLOGY, Vol. 10.

By: C. Ellington n, A. Cortes n, N. Faiz n, J. Mays, A. Fadly, R. Silva, I. Gimeno n 

author keywords: Marek's disease; vaccination; immunosuppression; LTR; recombinant vaccines; control
MeSH headings : Animals; Chickens; Herpesvirus 2, Gallid; Immunosuppression Therapy / veterinary; Marek Disease Vaccines / genetics; Meat; Reticuloendotheliosis virus; Terminal Repeat Sequences / genetics
TL;DR: It is shown that Md5-BAC-REV-LTR has the potential to be used as a MD vaccine and is highly protective against early challenge with vv+ MDV in commercial meat-type chickens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 26, 2021

2021 journal article

Cytokine expression in the eye and brain of chickens following infection with a very virulent plus Marek's disease virus strain

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 237.

By: C. Salvador, A. Cortes*, A. Pandiri & I. Gimeno* 

author keywords: Cytokine; Eye; Brain; Transient paralysis; Chicken
MeSH headings : Animals; Brain / immunology; Brain / pathology; Chickens; Cytokines / biosynthesis; Eye / immunology; Eye / pathology; Herpesvirus 2, Gallid / pathogenicity; Marek Disease / immunology; Marek Disease / pathology; Nervous System Diseases / immunology; Nervous System Diseases / pathology; Nervous System Diseases / veterinary; Nervous System Diseases / virology; Transcriptome; Virulence
TL;DR: The results suggest that MDV elicits different immune responses in the brain and in the eyes of infected chickens, and further studies on the pathogenesis of MDV in the eye could greatly contribute to the authors' knowledge on the chicken eye immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 3, 2021

2021 journal article

Replication of Marek's disease vaccines in turkey embryos and their effect on TLR-3 and IFN-gamma transcripts

AVIAN PATHOLOGY, 50(3), 227–233.

By: I. Gimeno n , W. Shaw n, A. Turner n, J. Bremen n, A. Cortes n, N. Faiz n, E. Gonder, K. Robbins*

author keywords: HVT; TLR-3; IFN-&#947; turkey; in ovo; vaccination
TL;DR: It was demonstrated that commercial turkey flocks got exposed to wild type HVT within the first days of life; therefore, there is a potential of interaction between wildtype HVT and rHVT when administered at day of age, and all evaluated vaccines replicated very well in turkey embryonic tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2020 journal article

In ovo vaccination with herpesvirus of turkey enhances innate and cellular responses in meat-type chickens: Effect of vaccine dose and strain

VACCINE, 38(31), 4837–4845.

By: A. Boone n, T. Kaser  n, A. Cortes n, R. Kulkarni  n, B. Abad  n, T. Villalobos*, J. Esandi*, F. Perozo*, S. Lemiere *, I. Gimeno n 

author keywords: Herpesvirus of turkey; Immunocompetence; In ovo vaccination; Chickens
MeSH headings : Animals; Chick Embryo; Chickens; Herpesvirus 1, Meleagrid; Marek Disease; Meat; Poultry Diseases / prevention & control; Vaccination; Viral Vaccines
TL;DR: It is demonstrated in ovo vaccination with HVT in meat-type chickens can accelerate innate and adaptive immunity and one could optimize such effect by modifying the vaccine dose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2019 journal article

Highly virulent Marek's disease virus strains affect T lymphocyte function and viability of splenocytes in commercial meat-type chickens

AVIAN PATHOLOGY, 48(6), 564–572.

By: I. Gimeno n , A. Cortes n, S. Reddy*, B. Abad  n, T. Kaser  n & A. Limsatanun n

author keywords: Marek's disease virus; immunosuppression; virulence; MHC-I; lymphocyte proliferation; spleen
MeSH headings : Animals; Cell Proliferation; Chickens / immunology; Chickens / virology; Female; Herpesvirus 2, Gallid / pathogenicity; Immunosuppression Therapy / veterinary; Marek Disease / virology; Poultry Diseases / virology; Spleen / virology; T-Lymphocytes / virology; Virulence
TL;DR: Results suggest that although cell death and decrease lymphocyte function seem to be related to MDV virulence and certainly will be associated with immunosuppression, they might not fully explain the previously reported MDV-IS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2019

2019 journal article

Study of Efficacy and Replication of Recombinant Vector Vaccines by Using Turkey Herpesvirus Combined with Other Marek's Disease Vaccines

AVIAN DISEASES, 63(2), 335–341.

By: I. Gimeno n , A. Cortes n, A. Reilley, T. Barbosa, I. Alvarado, R. Koopman, A. Martinez

author keywords: rHVT; vaccines; CVI988; control; Marek's disease
MeSH headings : Animals; Chickens; Female; Herpesvirus 1, Meleagrid / immunology; Herpesvirus 2, Gallid / immunology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / pharmacology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Vaccination / veterinary
TL;DR: The results show that, when combined with CVI988, HVT and rHVTs confer a similar level of protection against MD (>90%) regardless of whether CVI 988 was used at RD or at DD, however, the combination of rHVT with C VI988 at DD resulted in reduced replication rates of RHVT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2019

2018 journal article

Differential attenuation of Marek's disease virus-induced tumours and late-Marek's disease virus-induced immunosuppression

JOURNAL OF GENERAL VIROLOGY, 99(7), 927–936.

By: N. Faiz n, A. Cortes n, J. Guy n , S. Reddy* & I. Gimeno n 

author keywords: Marek's disease virus; immunosuppression; virulence; meq; MHC-I
MeSH headings : Animals; Antibodies, Viral / biosynthesis; Carcinogenesis / genetics; Carcinogenesis / immunology; Carcinogenesis / pathology; Chickens; Female; Herpesvirus 1, Gallid / genetics; Herpesvirus 1, Gallid / immunology; Herpesvirus 1, Gallid / pathogenicity; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / pathogenicity; Immunity, Humoral / drug effects; Immunologic Deficiency Syndromes / genetics; Immunologic Deficiency Syndromes / immunology; Immunologic Deficiency Syndromes / veterinary; Immunologic Deficiency Syndromes / virology; Lymphoma / genetics; Lymphoma / immunology; Lymphoma / veterinary; Lymphoma / virology; Marek Disease / genetics; Marek Disease / immunology; Marek Disease / pathology; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / immunology; RNA, Viral / genetics; RNA, Viral / immunology; Species Specificity; Viral Vaccines / administration & dosage; Virulence
TL;DR: It is suggested that the immunosuppressive ability of MDV might follow a continuous spectrum and only the most virulent MDVs can overcome a certain threshold level and induce clinical MDV-IS in the ILT model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Use of real-time PCR to rule out Marek's disease in the diagnosis of peripheral neuropathy

AVIAN PATHOLOGY, 47(4), 427–433.

By: S. Gall n, L. Korosi *, A. Cortes n, A. Delvecchio*, F. Prandini*, P. Mitsch, I. Gimeno n 

author keywords: Peripheral neuropathy; Marek's disease; diagnosis; real-time PCR; nerve enlargement
MeSH headings : Animals; Chickens / virology; DNA, Viral / analysis; DNA, Viral / genetics; Diagnosis, Differential; Mardivirus / genetics; Mardivirus / isolation & purification; Marek Disease / diagnosis; Marek Disease / pathology; Marek Disease / virology; Peripheral Nervous System Diseases / diagnosis; Peripheral Nervous System Diseases / pathology; Peripheral Nervous System Diseases / veterinary; Poultry Diseases / diagnosis; Poultry Diseases / pathology; Real-Time Polymerase Chain Reaction / veterinary
TL;DR: A case report shows for the first time how real-time PCR to detect oncogenic MDV is a very valuable tool in the differential diagnosis of PN and MD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of factors influencing the development of late Marek's disease virus-induced immunosuppression: virus pathotype and host sex

AVIAN PATHOLOGY, 46(4), 376–385.

By: N. Faiz n, A. Cortes n, J. Guy n , O. Fletcher n, T. Cimino & I. Gimeno n 

author keywords: MDV; ILTV; immunosuppression; pathotype; host sex
MeSH headings : Animals; Chickens; Female; Gene Expression Regulation / immunology; Male; Mardivirus / classification; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease / virology; MicroRNAs / genetics; MicroRNAs / metabolism; Sex Factors; Specific Pathogen-Free Organisms; Viral Vaccines / immunology
TL;DR: The findings suggest that late-MDV-IS is a unique feature of vv+ strains, and the role of two factors (MDV pathotype and host sex) on the development of this feature is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Early infection with Marek's disease virus can jeopardize protection conferred by laryngotracheitis vaccines: a method to study MDV-induced immunosuppression

AVIAN PATHOLOGY, 45(6), 606–615.

By: N. Faiz n, A. Cortes n, J. Guy n , O. Fletcher n, M. West n, E. Montiel, I. Gimeno n 

author keywords: Marek's disease; immunosuppression; laryngotracheitis; model; MDV-induced immunosuppression
MeSH headings : Animals; Chickens / immunology; Chickens / virology; Female; Herpesvirus 2, Gallid / immunology; Immunosuppression Therapy; Marek Disease / immunology; Marek Disease / virology; Models, Immunological; Specific Pathogen-Free Organisms; Tracheitis / prevention & control; Tracheitis / veterinary; Tracheitis / virology; Vaccination / veterinary; Viral Vaccines / immunology
TL;DR: The objective was to document the impact of late-MDV-IS on commercial poultry (meat-type chickens bearing MAb against MDV and that were vaccinated or unvaccinated against MD) and to optimize a model to study late- MDv-IS under laboratory conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Efficacy of Various HVT Vaccines (Conventional and Recombinant) Against Marek's Disease in Broiler Chickens: Effect of Dose and Age of Vaccination

AVIAN DISEASES, 60(3), 662–668.

By: I. Gimeno n , A. Cortes n, N. Faiz n, T. Villalobos, H. Badillo & T. Barbosa

author keywords: HVT; recombinant; vaccination; in ovo; MDV; control
MeSH headings : Age Factors; Animals; Chickens; Dose-Response Relationship, Immunologic; Female; Herpesvirus 1, Meleagrid / immunology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / pharmacology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Vaccination / veterinary; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / pharmacology
TL;DR: The results show that each HVT product is unique, regardless of being conventional or recombinant, in their ability to protect against MD and might require different PFUs to achieve its maximum efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Efficacy of various Marek's disease vaccines protocols for prevention of Marek's disease virus-induced immunosuppression

VACCINE, 34(35), 4180–4187.

By: N. Faiz n, A. Cortes n, J. Guy n , J. Fogle n & I. Gimeno n 

author keywords: MDV; Control; ILTV; Immunosuppression; Immune system; Vaccine
MeSH headings : Animals; Chickens; Female; Immune Tolerance; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / adverse effects; Neoplasms / virology; Poultry Diseases / prevention & control; Vaccination / methods; Vaccination / veterinary
TL;DR: It is demonstrated that currently used vaccine protocols confer high levels of protection against MDV-induced tumors (protection index=100), but do not protect against late-MDV-IS; thus, commercial poultry flocks could suffer late- MDv-IS even in complete absence of tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of Factors Influencing Efficacy of Vaccine Strain CVI988 Against Marek's Disease in Meat-Type Chickens

AVIAN DISEASES, 59(3), 400–409.

By: I. Gimeno n , A. Cortes n, N. Faiz n, T. Barbosa* & T. Villalobos*

author keywords: CVI988; vaccination; in ovo; meat type; MD; control; avian
MeSH headings : Animals; Chickens / classification; Genome, Viral; Lymphoid Tissue; Marek Disease / diagnosis; Marek Disease / prevention & control; Real-Time Polymerase Chain Reaction / veterinary; Viral Load; Viral Vaccines / immunology
TL;DR: The results show that, regardless of the origin of the vaccine, protection against early challenge with 648A was good when vaccines were administered at a high dose, confirming that early diagnosis is a very powerful tool with which to evaluate protection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluation of the Protection Efficacy of a Serotype 1 Marek's Disease Virus-Vectored Bivalent Vaccine Against Infectious Laryngotracheitis and Marek's Disease

Avian Diseases, 59(2), 255–262.

By: I. Gimeno n , A. Cortes n, N. Faiz n, B. Hernandez-Ortiz n, J. Guy n , H. Hunt*, R. Silva*

author keywords: Marek's disease; laryngotracheitis; poultry; avian; vaccine; control; herpesvirus
MeSH headings : Animals; Chickens; Female; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Gallid / immunology; Mardivirus / classification; Mardivirus / immunology; Marek Disease / prevention & control; Pilot Projects; Vaccines, DNA; Viral Vaccines / immunology; Virus Replication
TL;DR: Two recombinant vaccines against MD and LT are developed by using BAC&dgr;MEQ as a vector that carries either the LT virus (LTV) gene glycoprotein B (gB; BAC &Dgr; MEQ-gB) or LTV gene glyCoprotein J (gJ; Bac&dGr;MEZ-gJ) by using serotype 1 MDV as vectors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

In Ovo Vaccination with Turkey Herpesvirus Hastens Maturation of Chicken Embryo Immune Responses in Specific-Pathogen-Free Chickens

AVIAN DISEASES, 59(3), 375–383.

By: I. Gimeno n , N. Faiz n, A. Cortes n, T. Barbosa*, T. Villalobos* & A. Pandiri *

author keywords: HVT; vaccination; in ovo; immune system; immune competence; MDV; avian
MeSH headings : Animals; Antibodies, Viral / blood; Cell Proliferation; Chick Embryo / immunology; Chickens / immunology; Herpesvirus 1, Meleagrid / immunology; Lymphocytes / physiology; Marek Disease / prevention & control; Specific Pathogen-Free Organisms; Spleen / cytology; Vaccination / veterinary; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR: Results of this study show that it is possible to hasten maturation of the chicken embryo immune system by administering HVT in ovo and open new avenues to optimize the procedure to improve and strengthen the immunocompetency of commercial chickens at hatch. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Detection and Differentiation of CVI988 (Rispens Vaccine) from Other Serotype 1 Marek's Disease Viruses

AVIAN DISEASES, 58(2), 232–243.

By: I. Gimeno n , J. Dunn *, A. Cortes n, A. El-Gohary* & R. Silva*

author keywords: real time PCR; poultry; avian; diagnosis; vaccine; MDV; Rispens; CVI988
MeSH headings : Animals; Chick Embryo; Chickens; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 3, Gallid / genetics; Herpesvirus 3, Gallid / immunology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / genetics; Marek Disease Vaccines / immunology; Polymorphism, Single Nucleotide; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Real-Time Polymerase Chain Reaction / methods; Real-Time Polymerase Chain Reaction / veterinary; Vaccines, Attenuated / genetics; Vaccines, Attenuated / immunology
TL;DR: Validation of MAMA primers in in vivo samples demonstrated that oncogenic primers can be used for both early diagnosis of MD in feather pulp samples collected at 3 wk of age and confirmation of MD diagnosis in tumors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Optimization of the Protocols for Double Vaccination Against Marek's Disease by Using Commercially Available Vaccines: Evaluation of Protection, Vaccine Replication, and Activation of T Cells

AVIAN DISEASES, 56(2), 295–305.

By: I. Gimeno* , A. Cortes*, R. Witter* & A. Pandiri

author keywords: revaccination; Marek's disease; control; vaccine
MeSH headings : Animals; Chick Embryo; Chickens; DNA, Viral / analysis; Dose-Response Relationship, Immunologic; Immunization, Secondary / veterinary; Mardivirus / physiology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Real-Time Polymerase Chain Reaction / veterinary; Specific Pathogen-Free Organisms; T-Lymphocytes / immunology; Time Factors; Vaccination / veterinary
TL;DR: It is demonstrated that it is possible to improve efficacy of the currently available vaccines by using them in revaccination programs and to determine whether two features associated with Marek's disease vaccine-induced protection (activation of T cells and replication of vaccine virus) are involved in theRevaccination protocols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Chronological study of cytokine transcription in the spleen and lung of chickens after vaccination with serotype 1 Marek's disease vaccines

VACCINE, 29(8), 1583–1594.

By: I. Gimeno n  & A. Cortes n

author keywords: Marek's disease; Vaccine; Cytokine
MeSH headings : Animals; Chickens / immunology; Cytokines / biosynthesis; Herpesvirus 2, Gallid / immunology; Lung / immunology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Nitric Oxide Synthase Type II / biosynthesis; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Specific Pathogen-Free Organisms; Spleen / immunology; Time Factors; Vaccination / veterinary; Viral Load
TL;DR: It is demonstrated that MD vaccines administered subcutaneously elicit a pulmonary immune response and differences in the cytokine gene expression between HP and LP vaccinated chickens are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Comparison of Blood and Feather Pulp Samples for the Diagnosis of Marek's Disease and for Monitoring Marek's Disease Vaccination by Real Time-PCR

AVIAN DISEASES, 55(2), 302–310.

By: A. Cortes*, E. Montiel, S. Lemiere & I. Gimeno* 

author keywords: Marek's disease; real time-PCR; plaque assay; vaccines; diagnosis
MeSH headings : Animals; Chickens; DNA, Viral / isolation & purification; Feathers / virology; Mardivirus / genetics; Marek Disease / blood; Marek Disease / diagnosis; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Vaccination; Viral Plaque Assay
TL;DR: Comparison of blood and feather pulp (FP) samples for the diagnosis of Marek's disease (MD) and for monitoring MareK's diseases vaccination in chickens (serotypes 2 and 3 vaccines) by real time-PCR was evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Effect of Diluting Marek's Disease Vaccines on the Outcomes of Marek's Disease Virus Infection When Challenged with Highly Virulent Marek's Disease Viruses

AVIAN DISEASES, 55(2), 263–272.

By: I. Gimeno* , A. Cortes*, E. Montiel, S. Lemiere & A. Pandiri

author keywords: Marek's disease; control; vaccines; dilution
MeSH headings : Animals; Body Weight; DNA, Viral; Dose-Response Relationship, Immunologic; Female; Male; Mardivirus / pathogenicity; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Virulence
TL;DR: It was shown that dilution of MD vaccines can lead to reduced MD protection, reduced relative body weights, reduced vaccine DNA during the first 3 wk, and increased MDV DNA load. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Replication ability of three highly protective Marek's disease vaccines: implications in lymphoid organ atrophy and protection

AVIAN PATHOLOGY, 40(6), 573–579.

By: I. Gimeno n , R. Witter, A. Cortes n & W. Reed

MeSH headings : Analysis of Variance; Animals; Atrophy; Chickens; DNA Primers / genetics; Herpesvirus 2, Gallid / immunology; Herpesvirus 2, Gallid / pathogenicity; Immunohistochemistry; Lymphoid Tissue / pathology; Lymphoid Tissue / virology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / immunology; Real-Time Polymerase Chain Reaction; Vaccines, Attenuated / immunology; Virus Replication / physiology
TL;DR: The study of the target cells for the early infection in cell suspensions of blood and spleen showed that both non-adherent cell populations (enriched in lymphoid cells) and adherent cells (en enriched in monocytes/macrophages) supported MD virus infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Replication of recombinant herpesvirus of turkey expressing genes of infectious laryngotracheitis virus in specific pathogen free and broiler chickens following in ovo and subcutaneous vaccination

AVIAN PATHOLOGY, 40(4), 395–403.

By: I. Gimeno n , A. Cortes n, J. Guy n , E. Turpin* & C. Williams *

MeSH headings : Animals; Antibodies, Viral / blood; Chick Embryo; Chickens / immunology; Chickens / virology; Female; Herpesviridae Infections / immunology; Herpesviridae Infections / prevention & control; Herpesviridae Infections / veterinary; Herpesvirus 1, Gallid / genetics; Herpesvirus 1, Gallid / immunology; Herpesvirus 1, Gallid / physiology; Injections, Subcutaneous / veterinary; Organisms, Genetically Modified; Poultry Diseases / immunology; Poultry Diseases / prevention & control; Poultry Diseases / virology; Specific Pathogen-Free Organisms; Turkeys / virology; Vaccination / methods; Vaccination / veterinary; Vaccines, Synthetic / immunology; Viral Load; Viral Vaccines / administration & dosage; Viral Vaccines / immunology; Virus Replication / immunology
TL;DR: In vivo replication of rHVT-LT vaccine was slower than HVT vaccine, however, in vivo both rH VT-LT and HVT vaccines replicated at similar levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Evaluation of factors influencing replication of serotype 1 Marek's disease vaccines in the chicken lung

AVIAN PATHOLOGY, 39(2), 71–79.

By: I. Gimeno n  & A. Cortes n

MeSH headings : Aging; Animals; Chickens; DNA, Viral / genetics; Dose-Response Relationship, Immunologic; Genes, Viral; Injections, Subcutaneous; Lung / immunology; Lung / virology; Mardivirus / genetics; Mardivirus / physiology; Marek Disease / immunology; Marek Disease / prevention & control; Marek Disease Vaccines / administration & dosage; Marek Disease Vaccines / immunology; Viral Load; Virus Replication
TL;DR: It was shown that HP vaccines tend to replicate better than LP vaccines in the lung; and vaccine replication in the lungs within the first 10 days of age was affected by the age/route of inoculation but not by the dose of vaccine administered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Validation of Marek's Disease Diagnosis and Monitoring of Marek's Disease Vaccines from Samples Collected in FTA (R) Cards

AVIAN DISEASES, 53(4), 510–516.

By: A. Cortes n, E. Montiel & I. Gimeno n 

author keywords: Marek's disease; real-time PCR; FTA (R) cards; vaccines; diagnosis
MeSH headings : Animals; Chickens; DNA, Viral / analysis; Marek Disease / diagnosis; Marek Disease / prevention & control; Polymerase Chain Reaction / veterinary; Reproducibility of Results; Sequence Analysis, DNA / veterinary; Specimen Handling / methods; Specimen Handling / veterinary; Viral Load; Viral Vaccines / immunology
TL;DR: FTA cards are an excellent media to collect, transport, and archive samples for MD diagnosis and to monitor MD vaccines and are widely available, inexpensive, and adequate for the shipment of samples nationally and internationally. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Load of Challenge Marek's Disease Virus DNA in Blood as a Criterion for Early Diagnosis of Marek's Disease Tumors

AVIAN DISEASES, 52(2), 203–208.

By: I. Gimeno* , A. Cortes* & R. Silva*

author keywords: Marek's disease; vaccination; control; protection; monitoring
MeSH headings : Animals; Base Sequence; Chickens; DNA Primers / genetics; DNA, Viral / blood; DNA, Viral / genetics; Disease Outbreaks / prevention & control; Disease Outbreaks / veterinary; Female; Herpesvirus 1, Meleagrid / genetics; Herpesvirus 1, Meleagrid / isolation & purification; Herpesvirus 2, Gallid / genetics; Herpesvirus 2, Gallid / isolation & purification; Male; Marek Disease / diagnosis; Marek Disease / epidemiology; Marek Disease / prevention & control; Marek Disease / virology; Marek Disease Vaccines / genetics; Marek Disease Vaccines / pharmacology; Models, Biological; Viral Load / veterinary
TL;DR: It was shown that load of challenge MDV DNA but not load of HVT DNA in blood can be used as criterion for early diagnosis of Marek's disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Marek's Disease Virus Infection in the Eye: Chronological Study of the Lesions, Virus Replication, and Vaccine-Induced Protection

AVIAN DISEASES, 52(4), 572–580.

By: A. Pandiri, A. Cortes*, L. Lee* & I. Gimeno* 

author keywords: Marek's diseases; eye; retina; pathogenesis
MeSH headings : Animals; Chickens; Choroid / pathology; Eye Infections, Viral / pathology; Eye Infections, Viral / prevention & control; Eye Infections, Viral / veterinary; Eye Infections, Viral / virology; Female; Immunohistochemistry; Male; Mardivirus / immunology; Mardivirus / physiology; Marek Disease / immunology; Marek Disease / pathology; Marek Disease / prevention & control; Marek Disease Vaccines / immunology; Retina / pathology; Time Factors; Virus Replication / physiology
TL;DR: The effect of vaccination on the development of ocular lesions was studied chronologically after inoculating 1-day-old chickens with a very virulent MDV strain, Md5, to enhance the understanding of the nature and pattern of MDV infection in the eye. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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