Anne L. Crews

Works (30)

Updated: October 14th, 2025 22:23

2018 article

MARCKS and Lung Disease

Sheats, M. K., Yin, Q., Fang, S., Park, J., Crews, A. L., Parikh, I., … Adler, K. B. (2018, October 19). American Journal of Respiratory Cell and Molecular Biology, Vol. 60, pp. 16–27.

By: M. Sheats* , Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh*, B. Dickson*, K. Adler n

author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
topics (OpenAlex): Cellular Mechanics and Interactions; Skin and Cellular Biology Research
TL;DR: This article summarizes the structure and cellular function of MARCKS (also including MARC KS family proteins and MARCKSL1 [MARCKS‐like protein 1]). (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2016 article

An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice

Yin, Q., Fang, S., Park, J., Crews, A. L., Parikh, I., & Adler, K. B. (2016, August 24). American Journal of Respiratory Cell and Molecular Biology.

By: Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh* & K. Adler n

author keywords: myristoylated alanine-rich C kinase substrate; acute lung injury; LPS; neutrophils
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / drug therapy; Aerosols / administration & dosage; Aerosols / pharmacology; Animals; Behavior, Animal; Bronchoalveolar Lavage Fluid; Cytokines / metabolism; Female; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / metabolism; Leukocytes / metabolism; Lipopolysaccharides; Lung / drug effects; Lung / metabolism; Lung / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / metabolism; Mice, Inbred BALB C; Myristoylated Alanine-Rich C Kinase Substrate; NF-kappa B / metabolism; Peptides / administration & dosage; Peptides / pharmacology; Peptides / therapeutic use
topics (OpenAlex): Enzyme function and inhibition; Phosphodiesterase function and regulation; Nitric Oxide and Endothelin Effects
TL;DR: Results implicate MARCKS protein in the pathogenesis of ALI/ARDS and suggest that MARC KS-inhibitory peptide(s), delivered by inhalation, could represent a new and potent therapeutic treatment for ALi/ARDS, even if administered well after the disease process has begun. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro

Fang, S., Crews, A. L., Chen, W., Park, J., Yin, Q., Ren, X.-R., & Adler, K. B. (2013, February 2). American Journal of Physiology-Lung Cellular and Molecular Physiology.

By: S. Fang n, A. Crews n, W. Chen *, J. Park n, Q. Yin n, X. Ren*, K. Adler n

author keywords: airway; mucin; secretion; myristoylated alanine-rich C kinase substrate; heat shock protein 70
MeSH headings : Base Sequence; Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiology; Cell Differentiation; Cells, Cultured; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / physiology; HSP40 Heat-Shock Proteins / physiology; HSP70 Heat-Shock Proteins / antagonists & inhibitors; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / physiology; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / genetics; Membrane Proteins / physiology; Microscopy, Confocal; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport; Pyrimidinones / pharmacology; RNA, Small Interfering / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): Heat shock proteins research; Toxin Mechanisms and Immunotoxins; Endoplasmic Reticulum Stress and Disease
TL;DR: Evidence is provided of a role for HSP70 in mediating mucin secretion via interactions with MARCKS and that these interactions are critical for the cytoplasmic translocation of MARC KS upon its phosphorylation. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Calpain and MARCKS protein regulation of airway mucin secretion

Lampe, W. R., Park, J., Fang, S., Crews, A. L., & Adler, K. B. (2012, June 18). Pulmonary Pharmacology & Therapeutics.

By: W. Lampe n, J. Park n, S. Fang n, A. Crews n & K. Adler n

author keywords: Airway; Mucin; MARCKS; Calpain; Secretion
MeSH headings : Bronchi / cytology; Bronchi / metabolism; Calpain / antagonists & inhibitors; Calpain / metabolism; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells / metabolism; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides / administration & dosage; Oligopeptides / pharmacology; Protein Kinase C / metabolism; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): RNA regulation and disease; Galectins and Cancer Biology; Lysosomal Storage Disorders Research
TL;DR: Cleavage of MARCKS by Calpain may have an important role in regulation of the PKC/MARCKS pathway regulating airway mucin secretion, as opposed to the original hypothesis, inactivating Calpain caused a decrease rather than an increase in secretion. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein

Journal of Leukocyte Biology, 92(3), 633–639.

By: T. Green n, J. Park n, Q. Yin n, S. Fang n, A. Crews n, S. Jones n , K. Adler n

author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
topics (OpenAlex): Cellular Mechanics and Interactions; Cell Adhesion Molecules Research; S100 Proteins and Annexins
TL;DR: Results suggest that MARCKS is involved in directed migration of macrophages via a process involving its phosphorylation, cytoplasmic translocation, and interaction with actin. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2011 article

A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

Seibold, M. A., Wise, A. L., Speer, M. C., Steele, M. P., Brown, K. K., Loyd, J. E., … Schwartz, D. A. (2011, April 20). New England Journal of Medicine.

By: M. Seibold *, A. Wise*, M. Speer*, M. Steele*, K. Brown *, J. Loyd *, T. Fingerlin *, W. Zhang* ...

MeSH headings : Aged; Case-Control Studies; Chromosomes, Human, Pair 11; Female; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Idiopathic Pulmonary Fibrosis / genetics; Linkage Disequilibrium; Lung / metabolism; Lung Diseases, Interstitial / genetics; Male; Middle Aged; Mucin-5B / genetics; Mucin-5B / metabolism; Mutation; Polymorphism, Single Nucleotide; Promoter Regions, Genetic
topics (OpenAlex): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis; Neonatal Respiratory Health Research; Chronic Obstructive Pulmonary Disease (COPD) Research
TL;DR: The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"

Raiford, K. L., Park, J., Lin, K.-W., Fang, S., Crews, A. L., & Adler, K. B. (2011, September 6). Respiratory Research.

By: K. Raiford*, J. Park n, K. Lin *, S. Fang n, A. Crews n & K. Adler n

MeSH headings : Bronchi / chemistry; Bronchi / metabolism; Cells, Cultured; Cytoplasmic Granules / chemistry; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Goblet Cells / chemistry; Goblet Cells / metabolism; Humans; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / metabolism; Membrane Glycoproteins / ultrastructure; Mucins / chemistry; Mucins / metabolism; Respiratory Mucosa / chemistry; Respiratory Mucosa / metabolism
topics (OpenAlex): Cystic Fibrosis Research Advances; Asthma and respiratory diseases; Inhalation and Respiratory Drug Delivery
TL;DR: This work isolated mucin granules and granule membranes from primary cultures of well differentiated human bronchial epithelial cells utilizing a novel technique of immuno-isolation, based on the presence of the calcium activated chloride channel hCLCA1 on thegranule membranes, and verified via Western blotting and co-immunoprecipitation that MARCKS, HSP70, CSP and hCL CA1 were present on the granule membrane and associated with each other. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?

Green, T. D., Crews, A. L., Park, J., Fang, S., & Adler, K. B. (2011, February 1). Biochimica Et Biophysica Acta (BBA) - General Subjects.

By: T. Green, A. Crews n, J. Park n, S. Fang n & K. Adler n

author keywords: MARCKS; Mucin; Secretion; Asthma
MeSH headings : Animals; Asthma / etiology; Humans; Inflammation / etiology; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / physiology; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate
topics (OpenAlex): Protein Kinase Regulation and GTPase Signaling; Signaling Pathways in Disease
TL;DR: The properties of MARCKS and how the protein may regulate mucin secretion at a cellular level will be discussed and the roles ofMARCKS in airway inflammation related to both influx of inflammatory cells into the lung and release of granules containing inflammatory mediators by these cells will be explored. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

MARCKS and Related Chaperones Bind to Unconventional Myosin V Isoforms in Airway Epithelial Cells

Lin, K.-W., Fang, S., Park, J., Crews, A. L., & Adler, K. B. (2010, March 4). American Journal of Respiratory Cell and Molecular Biology.

By: K. Lin n, S. Fang n, J. Park n, A. Crews n & K. Adler n

author keywords: airway; mucin; MARCKS; chaperones; myosin
MeSH headings : Bronchi / pathology; Epithelial Cells / cytology; Gene Expression Regulation; HSP70 Heat-Shock Proteins / chemistry; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Biological; Molecular Chaperones; Mucins / metabolism; Myosin Heavy Chains / chemistry; Myosin Type V / chemistry; Myristoylated Alanine-Rich C Kinase Substrate; Protein Binding; Protein Isoforms; Tetradecanoylphorbol Acetate / chemistry; Transfection
topics (OpenAlex): Signaling Pathways in Disease; Viral Infections and Immunology Research; RNA regulation and disease
TL;DR: It is reported that myristoylated alanine-rich C kinase substrate (MARCKS) also interacts with unconventional myosin isoforms within these cells, and further molecular interactions between MARCKS and these chaperones/cytoskeletal proteins are elucidated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

A MARCKS-related peptide attenuates both mucin hypersecretion and inflammatory cell infiltration in an elastase model of chronic bronchitis.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A332.

By: A. Crews, E. Potts, J. Voynow, B. Fischer, S. Bumgardner, K. Adler, W. Foster

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A MARCKS-related peptide inhibits MUC5AC expression in airway epithelial cells isolated from asthmatic subjects.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A814.

By: Y. Wang, K. Adler, D. Slade, T. Church, R. Webb, H. Chu, D. Jinwright, A. Crews, M. Kraft

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A potential role for airway epithelial cell mucin genes in fibrogenesis.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A727.

By: J. Park, A. Crews, S. Alper, D. Schwartz & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

MARCKS regulation of mucin secretion by airway epithelial cells in vitro: interactions with chaperone proteins.

American Journal of Respiratory Cell and Molecular Biology, 102, 949–955.

By: J. Park, S. Fang, A. Crews, K. Lin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 article

MARCKS regulation of mucin secretion by airway epithelium in vitro - Interaction with chaperones

Joungjoa Park; Shijing Fang; Anne Crews; Ko-Wei Lin; Kenneth Adler

topics (OpenAlex):
Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.

European Respiratory Journal, 34, 43–46.

By: M. Kraft, K. Adler, J. Ingram, A. Crews, T. Atkinson, C. Cairns, D. Krause, H. Chu

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Mycoplasma pneumoniaeinduces airway epithelial cell expression of MUC5AC in asthma

Kraft, M., Adler, K. B., Ingram, J. L., Crews, A. L., Atkinson, T. P., Cairns, C. B., … Chu, H. W. (2007, December 31). European Respiratory Journal.

By: M. Kraft *, K. Adler n, J. Ingram *, A. Crews n, T. Atkinson *, C. Cairns *, D. Krause, H. Chu *

author keywords: asthma; epithelial cell; MUC5AC; Mycoplasma pneumoniae; toll-like receptor 2
MeSH headings : Adult; Asthma / immunology; Asthma / metabolism; Asthma / microbiology; Bronchoscopy / methods; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / cytology; Epithelial Cells / microbiology; Female; Gene Expression Regulation; Humans; Male; Models, Biological; Mucin 5AC; Mucins / biosynthesis; Mucins / metabolism; Mycoplasma pneumoniae / metabolism; Mycoplasma pneumoniae / physiology; NF-kappa B / metabolism; Time Factors; Toll-Like Receptor 2 / metabolism
topics (OpenAlex): Peptidase Inhibition and Analysis; Monoclonal and Polyclonal Antibodies Research; Microbial infections and disease research
TL;DR: Mycoplasma pneumoniae exposure significantly increased MUC5AC mRNA and protein expression preferentially in airway epithelial cells isolated from asthmatic subjects, and the toll-like receptor 2 pathway may be involved in this process. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

A peptide against the N-terminus of MARCKS protein attenuates leukocyte migration.

404nOtfound, Vol. 175, p. A915.

By: T. Green, B. Eckert, Y. Sharief, A. Crews, K. Adler & S. Jones 

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Anti-inflammatory effects of budesonide and formoterol in primary cultures of human airway epithelial cells.

404nOtfound, Vol. 175, p. A178.

By: J. Park, S. Takashi, A. Crews, A. Miller-Larsson & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.

404nOtfound, Vol. 175, p. A324.

By: M. Kraft, H. Nijira Lugogo, K. Adler, A. Crews, T. Moss, M. Stalls, T. Church, D. Slade, D. Beaver, H. Chu

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro

Lin, K.-W., Park, J., Crews, A. L., Li, Y., & Adler, K. B. (2007, November 10). The International Journal of Biochemistry & Cell Biology.

By: K. Lin n, J. Park n, A. Crews n, Y. Li n & K. Adler n

author keywords: PAR-2; mucin; airway; secretion
MeSH headings : Bronchi / cytology; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Mucins / genetics; Mucins / metabolism; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Oligopeptides / pharmacology; Papillomaviridae / physiology; RNA, Small Interfering / pharmacology; Receptor, PAR-2 / agonists; Receptor, PAR-2 / genetics; Receptor, PAR-2 / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism; Time Factors; Transfection
topics (OpenAlex): Blood Coagulation and Thrombosis Mechanisms; Coagulation, Bradykinin, Polyphosphates, and Angioedema; Heart Failure Treatment and Management
TL;DR: The results suggest that, since PAR-2 activation only weakly increases mucin secretion by human airway epithelial cells in vitro,PAR-2 probably is not a significant contributor to mucin hypersecretion in inflamed airways. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Protein Kinase Cδ Regulates Airway Mucin Secretion via Phosphorylation of MARCKS Protein

Park, J.-A., Crews, A. L., Lampe, W. R., Fang, S., Park, J., & Adler, K. B. (2007, November 30). American Journal Of Pathology.

By: J. Park n, A. Crews n, W. Lampe n, S. Fang n, J. Park n & K. Adler n

MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Bronchi / drug effects; Bronchi / enzymology; Bronchi / metabolism; Bryostatins / pharmacology; Cell Line; Enzyme Activation; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / genetics; Protein Kinase C-delta / physiology; Protein Kinase Inhibitors / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
topics (OpenAlex): Cystic Fibrosis Research Advances; Glycosylation and Glycoproteins Research; Proteoglycans and glycosaminoglycans research
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Source: Web Of Science
Added: August 6, 2018

2007 article

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.

404nOtfound, Vol. 175, p. A752.

By: J. Park, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Proteomic analysis of mucin granule membrane-associated proteins in human airway epithelial cells: a mechanistic link between MARCKS and hClCA1?

404nOtfound, Vol. 175, p. A511.

By: K. Raiford, K. Lin, J. Park, S. Fang, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

The (S)?enantiomer of albuterol activates expression of iNOS via activation of NF-kB in primary cultures of normal human bronchial epithelial cells.

404nOtfound, Vol. 175, p. A178.

By: J. Waterman, J. Park, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro

Respiratory Research, 7, 35.

By: B. Chorley, A. Crews, Y. Li, K. Adler, M. Minnicozzi & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells

In Vitro Cellular & Developmental Biology. Animal, 41(7), 217–224.

By: S. Lankford, M. Macchione, A. Crews, S. McKane, N. Akley & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Differential effects of albuterol isomers on normal human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A205.

By: B. Chorley, L. Martin, A. Crews, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Proliferation of the Airway Epithelium in Asthma

Booth, B. W., Newcomb, D. C., McKane, S. A., Crews, A. L., Adler, K. B., Bonner, J. C., & Martin, L. D. (2003, March 1). CHEST Journal.

By: B. Booth  n, D. Newcomb  n, S. McKane n, A. Crews n, K. Adler n, J. Bonner *, L. Martin n

MeSH headings : Asthma / pathology; Asthma / physiopathology; Cell Physiological Phenomena; Humans; In Vitro Techniques; Inflammation / pathology; Inflammation / physiopathology; Respiratory Mucosa / pathology; Respiratory Mucosa / physiopathology
topics (OpenAlex): Asthma and respiratory diseases; Cancer-related gene regulation
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Source: Web Of Science
Added: August 6, 2018

2002 article

Secretion-Competent Mouse Tracheal Epithelial Cell Culture From the Genetically Altered Mouse

Martin, L. D., Adler, K. B., Akley, N. J., Crews, A., & Sharova, L. (2002, March 1). CHEST Journal.

By: L. Martin n, K. Adler n, N. Akley n, A. Crews n & L. Sharova*

topics (OpenAlex): Tracheal and airway disorders; Neonatal Respiratory Health Research
TL;DR: This work presents a new Epithelial Repair Model of In Vitro Gene Expression in an http://chestjournal.chestpubs.org/content/121/3_suppl/79S.xhtml ( distributed without the prior written permission of the copyright holder). (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2000 article

C-Terminal Alternative Splicing Changes the Gating Properties of a Human Spinal Cord Calcium Channel α1A Subunit

Krovetz, H. S., Helton, T. D., Crews, A. L., & Horne, W. A. (2000, October 15). Journal of Neuroscience.

By: H. Krovetz n, T. Helton n, A. Crews n & W. Horne n

MeSH headings : Alternative Splicing; Amino Acid Substitution; Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Cells, Cultured; Cerebellum / metabolism; Exons; Gene Expression; Humans; Ion Channel Gating / genetics; Membrane Potentials / physiology; Microinjections; Molecular Sequence Data; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oocytes / metabolism; Patch-Clamp Techniques; Protein Isoforms / genetics; Protein Isoforms / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Spinal Cord / metabolism; Xenopus
topics (OpenAlex): Ion channel regulation and function; Neuroscience and Neuropharmacology Research; Nicotinic Acetylcholine Receptors Study
TL;DR: It is demonstrated that C-terminal structural changes alone can influence the way in which α1A subunits respond to a depolarizing stimulus and add to the developing picture of the C terminus as a critical domain in the regulation of Ca2+ channel function. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

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