Anne L. Crews

Works (31)

Updated: July 28th, 2023 21:16
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2019 review

MARCKS and Lung Disease

[Review of ]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 60(1), 16–27.

By: M. Sheats* , Q. Yin n, S. Fang n, J. Park n, A. Crews n, I. Parikh*, B. Dickson*, K. Adler n

author keywords: MARCKS; lung disease; inflammation; cancer
MeSH headings : Animals; Humans; Lung Diseases / metabolism; Lung Diseases / physiopathology; Myristoylated Alanine-Rich C Kinase Substrate / metabolism
Sources: Web Of Science, ORCID
Added: January 14, 2019

2016 journal article

An Inhaled Inhibitor of Myristoylated Alanine-Rich C Kinase Substrate Reverses LPS-Induced Acute Lung Injury in Mice

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 55(5), 617–622.

By: Q. Yin n, S. Fang n, J. Park*, A. Crews n, I. Parikh* & K. Adler n

author keywords: myristoylated alanine-rich C kinase substrate; acute lung injury; LPS; neutrophils
MeSH headings : Acute Lung Injury / chemically induced; Acute Lung Injury / drug therapy; Aerosols / administration & dosage; Aerosols / pharmacology; Animals; Behavior, Animal; Bronchoalveolar Lavage Fluid; Cytokines / metabolism; Female; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / metabolism; Leukocytes / metabolism; Lipopolysaccharides; Lung / drug effects; Lung / metabolism; Lung / pathology; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / metabolism; Mice, Inbred BALB C; Myristoylated Alanine-Rich C Kinase Substrate; NF-kappa B / metabolism; Peptides / administration & dosage; Peptides / pharmacology; Peptides / therapeutic use
Source: Web Of Science
Added: August 6, 2018

2013 journal article

MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 304(8), L511–L518.

By: S. Fang n, A. Crews n, W. Chen *, J. Park n, Q. Yin n, X. Ren*, K. Adler n

author keywords: airway; mucin; secretion; myristoylated alanine-rich C kinase substrate; heat shock protein 70
MeSH headings : Base Sequence; Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Bronchi / physiology; Cell Differentiation; Cells, Cultured; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / physiology; HSP40 Heat-Shock Proteins / physiology; HSP70 Heat-Shock Proteins / antagonists & inhibitors; HSP70 Heat-Shock Proteins / genetics; HSP70 Heat-Shock Proteins / physiology; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / genetics; Membrane Proteins / physiology; Microscopy, Confocal; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport; Pyrimidinones / pharmacology; RNA, Small Interfering / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tetradecanoylphorbol Acetate / pharmacology
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Calpain and MARCKS protein regulation of airway mucin secretion

PULMONARY PHARMACOLOGY & THERAPEUTICS, 25(6), 427–431.

By: W. Lampe n, J. Park n, S. Fang n, A. Crews n & K. Adler n

author keywords: Airway; Mucin; MARCKS; Calpain; Secretion
MeSH headings : Bronchi / cytology; Bronchi / metabolism; Calpain / antagonists & inhibitors; Calpain / metabolism; Cell Line; Dose-Response Relationship, Drug; Epithelial Cells / metabolism; Fluorescence; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oligopeptides / administration & dosage; Oligopeptides / pharmacology; Protein Kinase C / metabolism; Tetradecanoylphorbol Acetate / pharmacology
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Directed migration of mouse macrophages in vitro involves myristoylated alanine-rich C-kinase substrate (MARCKS) protein

Journal of Leukocyte Biology, 92(3), 633–639.

By: T. Green n, J. Park n, Q. Yin n, S. Fang n, A. Crews n, S. Jones n , K. Adler n

author keywords: cytoplasmic translocation; J774A.1 cells; monocyte chemotactic protein 1; chemotaxis
MeSH headings : Actin Cytoskeleton / immunology; Actin Cytoskeleton / metabolism; Animals; Blotting, Western; Chemotaxis, Leukocyte / physiology; Intracellular Signaling Peptides and Proteins / immunology; Intracellular Signaling Peptides and Proteins / metabolism; Macrophages / immunology; Macrophages / metabolism; Membrane Proteins / immunology; Membrane Proteins / metabolism; Mice; Microscopy, Confocal; Myristoylated Alanine-Rich C Kinase Substrate; Protein Transport / physiology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2011 journal article

A Common MUC5B Promoter Polymorphism and Pulmonary Fibrosis

NEW ENGLAND JOURNAL OF MEDICINE, 364(16), 1503–1512.

By: M. Seibold *, A. Wise*, M. Speer*, M. Steele*, K. Brown *, J. Loyd*, T. Fingerlin*, W. Zhang * ...

MeSH headings : Aged; Case-Control Studies; Chromosomes, Human, Pair 11; Female; Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Idiopathic Pulmonary Fibrosis / genetics; Linkage Disequilibrium; Lung / metabolism; Lung Diseases, Interstitial / genetics; Male; Middle Aged; Mucin-5B / genetics; Mucin-5B / metabolism; Mutation; Polymorphism, Single Nucleotide; Promoter Regions, Genetic
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Mucin granule-associated proteins in human bronchial epithelial cells: the airway goblet cell "granulome"

RESPIRATORY RESEARCH, 12.

By: K. Raiford*, J. Park n, K. Lin *, S. Fang n, A. Crews n & K. Adler n

MeSH headings : Bronchi / chemistry; Bronchi / metabolism; Cells, Cultured; Cytoplasmic Granules / chemistry; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Goblet Cells / chemistry; Goblet Cells / metabolism; Humans; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / metabolism; Membrane Glycoproteins / ultrastructure; Mucins / chemistry; Mucins / metabolism; Respiratory Mucosa / chemistry; Respiratory Mucosa / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 review

Regulation of mucin secretion and inflammation in asthma: A role for MARCKS protein?

[Review of ]. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(11), 1110–1113.

By: T. Green n, A. Crews n, J. Park n, S. Fang n & K. Adler n

author keywords: MARCKS; Mucin; Secretion; Asthma
MeSH headings : Animals; Asthma / etiology; Humans; Inflammation / etiology; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / physiology; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate
Source: Web Of Science
Added: August 6, 2018

2010 journal article

MARCKS and Related Chaperones Bind to Unconventional Myosin V Isoforms in Airway Epithelial Cells

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 43(2), 131–136.

By: K. Lin n, S. Fang n, J. Park n, A. Crews n & K. Adler n

author keywords: airway; mucin; MARCKS; chaperones; myosin
MeSH headings : Bronchi / pathology; Epithelial Cells / cytology; Gene Expression Regulation; HSP70 Heat-Shock Proteins / chemistry; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Biological; Molecular Chaperones; Mucins / metabolism; Myosin Heavy Chains / chemistry; Myosin Type V / chemistry; Myristoylated Alanine-Rich C Kinase Substrate; Protein Binding; Protein Isoforms; Tetradecanoylphorbol Acetate / chemistry; Transfection
Source: Web Of Science
Added: August 6, 2018

2010 article

MARCKS-related peptide modulates in vivo the secretion of airway Muc5ac (Retracted article. See vol. 309, pg. L 750, 2015)

Foster, W. M., Adler, K. B., Crews, A. L., Potts, E. N., Fischer, B. M., & Voynow, J. A. (2010, September). AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Vol. 299, pp. L345–L352.

By: W. Foster*, K. Adler n, A. Crews n, E. Potts*, B. Fischer* & J. Voynow*

author keywords: myristoylated alanine-rich C kinase substrate; airway hyperresponsiveness; elastase; serotonin
MeSH headings : Aerosols; Animals; Bronchoalveolar Lavage Fluid / chemistry; Cytokines / metabolism; Goblet Cells / pathology; Inflammation / prevention & control; Inflammation Mediators / metabolism; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Leukocyte Elastase / pharmacology; Lung / drug effects; Lung / physiopathology; Male; Membrane Proteins / antagonists & inhibitors; Metaplasia / chemically induced; Methacholine Chloride / administration & dosage; Mice; Mice, Inbred BALB C; Mucin 5AC / antagonists & inhibitors; Mucin 5AC / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments / pharmacology; Respiratory Hypersensitivity / chemically induced; Respiratory Hypersensitivity / physiopathology; Respiratory System / drug effects; Respiratory System / metabolism; Serotonin
Source: Web Of Science
Added: August 6, 2018

2008 article

A MARCKS-related peptide attenuates both mucin hypersecretion and inflammatory cell infiltration in an elastase model of chronic bronchitis.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A332.

By: A. Crews, E. Potts, J. Voynow, B. Fischer, S. Bumgardner, K. Adler, W. Foster

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A MARCKS-related peptide inhibits MUC5AC expression in airway epithelial cells isolated from asthmatic subjects.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A814.

By: Y. Wang, K. Adler, D. Slade, T. Church, R. Webb, H. Chu, D. Jinwright, A. Crews, M. Kraft

Source: NC State University Libraries
Added: August 6, 2018

2008 article

A potential role for airway epithelial cell mucin genes in fibrogenesis.

American Journal of Respiratory and Critical Care Medicine, Vol. 177, p. A727.

By: J. Park, A. Crews, S. Alper, D. Schwartz & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

MARCKS regulation of mucin secretion by airway epithelial cells in vitro: interactions with chaperone proteins.

American Journal of Respiratory Cell and Molecular Biology, 102, 949–955.

By: J. Park, S. Fang, A. Crews, K. Lin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

MARCKS regulation of mucin secretion by airway epithelium in vitro - Interaction with chaperones

American Journal of Respiratory Cell and Molecular Biology, 39(1), 68–76.

By: J. Park, S. Fang, A. Crews, K. Lin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.

European Respiratory Journal, 34, 43–46.

By: M. Kraft, K. Adler, J. Ingram, A. Crews, T. Atkinson, C. Cairns, D. Krause, H. Chu

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma

EUROPEAN RESPIRATORY JOURNAL, 31(1), 43–46.

By: M. Kraft, K. Adler*, J. Ingram, A. Crews*, T. Atkinson, C. Cairns, D. Krause, H. Chu

author keywords: asthma; epithelial cell; MUC5AC; Mycoplasma pneumoniae; toll-like receptor 2
MeSH headings : Adult; Asthma / immunology; Asthma / metabolism; Asthma / microbiology; Bronchoscopy / methods; Enzyme-Linked Immunosorbent Assay; Epithelial Cells / cytology; Epithelial Cells / microbiology; Female; Gene Expression Regulation; Humans; Male; Models, Biological; Mucin 5AC; Mucins / biosynthesis; Mucins / metabolism; Mycoplasma pneumoniae / metabolism; Mycoplasma pneumoniae / physiology; NF-kappa B / metabolism; Time Factors; Toll-Like Receptor 2 / metabolism
Source: Web Of Science
Added: August 6, 2018

2008 review

Protease-activated receptor-2 (PAR-2) is a weak enhancer of mucin secretion by human bronchial epithelial cells in vitro

[Review of ]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 40(6-7), 1379–1388.

By: K. Lin n, J. Park n, A. Crews n, Y. Li n & K. Adler n

author keywords: PAR-2; mucin; airway; secretion
MeSH headings : Bronchi / cytology; Cell Culture Techniques; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Cells, Cultured; Dose-Response Relationship, Drug; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Mucins / genetics; Mucins / metabolism; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Oligopeptides / pharmacology; Papillomaviridae / physiology; RNA, Small Interfering / pharmacology; Receptor, PAR-2 / agonists; Receptor, PAR-2 / genetics; Receptor, PAR-2 / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism; Time Factors; Transfection
Source: Web Of Science
Added: August 6, 2018

2007 article

A peptide against the N-terminus of MARCKS protein attenuates leukocyte migration.

404nOtfound, Vol. 175, p. A915.

By: T. Green, B. Eckert, Y. Sharief, A. Crews, K. Adler & S. Jones 

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Anti-inflammatory effects of budesonide and formoterol in primary cultures of human airway epithelial cells.

404nOtfound, Vol. 175, p. A178.

By: J. Park, S. Takashi, A. Crews, A. Miller-Larsson & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Mycoplasma pneumoniae increases airway epithelial cell MUC5AC expression in asthma.

404nOtfound, Vol. 175, p. A324.

By: M. Kraft, H. Nijira Lugogo, K. Adler, A. Crews, T. Moss, M. Stalls, T. Church, D. Slade, D. Beaver, H. Chu

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein

AMERICAN JOURNAL OF PATHOLOGY, 171(6), 1822–1830.

By: J. Park n, A. Crews n, W. Lampe n, S. Fang n, J. Park n & K. Adler n

MeSH headings : Acetophenones / pharmacology; Benzopyrans / pharmacology; Bronchi / drug effects; Bronchi / enzymology; Bronchi / metabolism; Bryostatins / pharmacology; Cell Line; Enzyme Activation; Epithelial Cells / drug effects; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C-delta / antagonists & inhibitors; Protein Kinase C-delta / genetics; Protein Kinase C-delta / physiology; Protein Kinase Inhibitors / pharmacology; Tetradecanoylphorbol Acetate / pharmacology
Source: Web Of Science
Added: August 6, 2018

2007 article

Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein.

404nOtfound, Vol. 175, p. A752.

By: J. Park, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Proteomic analysis of mucin granule membrane-associated proteins in human airway epithelial cells: a mechanistic link between MARCKS and hClCA1?

404nOtfound, Vol. 175, p. A511.

By: K. Raiford, K. Lin, J. Park, S. Fang, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2007 article

The (S)?enantiomer of albuterol activates expression of iNOS via activation of NF-kB in primary cultures of normal human bronchial epithelial cells.

404nOtfound, Vol. 175, p. A178.

By: J. Waterman, J. Park, A. Crews & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro

Respiratory Research, 7, 35.

By: B. Chorley, A. Crews, Y. Li, K. Adler, M. Minnicozzi & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells

In Vitro Cellular & Developmental Biology. Animal, 41(7), 217–224.

By: S. Lankford, M. Macchione, A. Crews, S. McKane, N. Akley & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Differential effects of albuterol isomers on normal human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A205.

By: B. Chorley, L. Martin, A. Crews, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Proliferation of the airway epithelium in asthma - Are inflammatory cells required?

Booth, B. W., Newcomb, D. C., McKane, S. A., Crews, A. L., Adler, K. B., Bonner, J. C., & Martin, L. D. (2003, March). CHEST, Vol. 123, pp. 384S–385S.

By: B. Booth  n, D. Newcomb  n, S. McKane n, A. Crews n, K. Adler n, J. Bonner*, L. Martin n

MeSH headings : Asthma / pathology; Asthma / physiopathology; Cell Physiological Phenomena; Humans; In Vitro Techniques; Inflammation / pathology; Inflammation / physiopathology; Respiratory Mucosa / pathology; Respiratory Mucosa / physiopathology
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Secretion-competent mouse tracheal epithelial cell culture from the genetically altered mouse - Pathway analysis via gene array

Chest, 121(3), 79S.

By: L. Martin n, K. Adler n, N. Akley n, A. Crews n & L. Sharova*

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

C-terminal alternative splicing changes the gating properties of a human spinal cord calcium channel alpha 1A subunit

Journal of Neuroscience, 20(20), 7564–7570.

By: H. Krovetz n, T. Helton n, A. Crews n & W. Horne n

MeSH headings : Alternative Splicing; Amino Acid Substitution; Animals; Calcium Channels / genetics; Calcium Channels / metabolism; Cells, Cultured; Cerebellum / metabolism; Exons; Gene Expression; Humans; Ion Channel Gating / genetics; Membrane Potentials / physiology; Microinjections; Molecular Sequence Data; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oocytes / metabolism; Patch-Clamp Techniques; Protein Isoforms / genetics; Protein Isoforms / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Spinal Cord / metabolism; Xenopus
Source: NC State University Libraries
Added: August 6, 2018