Amanda Lee Ziegler
Also known as: Amanda L. Ziegler
Works (35)
Updated: July 18th, 2023 21:16
2022 article
Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period
Ziegler, A. L., Erwin, S., Caldwell, M. L., Touvron, M. S., Pridgen, T. A., Magness, S. T., … Blikslager, A. T. (2022, November 4).
Source: ORCID
Added: November 5, 2022
2022 article
Mechanisms and modeling of wound repair in the intestinal epithelium
Boger, K. D., Sheridan, A. E., Ziegler, A. L., & Blikslager, A. T. (2022, June 13). TISSUE BARRIERS, Vol. 6.
author keywords: IPEC-J2 cells; transepithelial electrical resistance; injury barrier function; cell model
MeSH headings : Humans; Caco-2 Cells; Intestinal Mucosa / metabolism; Intestines; Ischemia
Sources: ORCID, Web Of Science
Added: June 12, 2022
2022 journal article
Multi-Institutional Retrospective Case-Control Study Evaluating Clinical Outcomes of Foals with Small Intestinal Strangulating Obstruction: 2000-2020
ANIMALS, 12(11).
author keywords: horse; colic; foal; ischemia; small intestinal strangulating obstruction; surgery
www.mdpi.com (publisher PDF)
Sources: ORCID, Web Of Science
Added: May 28, 2022
2022 review
Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: intestinal microbiota; translational models; pig models; gut commensals; gastrointestinal disease
Sources: Web Of Science, ORCID
Added: May 23, 2022
2021 journal article
Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic
ANIMALS, 11(12).
author keywords: horse; colic; ischemia-reperfusion injury; intestinal barrier repair; enteric nervous system; enteric glial cells; tight junction proteins
Sources: ORCID, Web Of Science
Added: November 25, 2021
2021 review
Postoperative Ileus: Comparative Pathophysiology and Future Therapies
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: intestine; equine; surgery; barrier function; enteric glia and neurons; microbiota
Sources: Web Of Science, ORCID
Added: October 12, 2021
2021 journal article
Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function
International Journal of Molecular Sciences, 22(13), 6729.
author keywords: probiotics; prebiotics; bioactive compounds; intestinal barrier function; tight junctions; toll-like receptors; intestinal microbiota
MeSH headings : Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Humans; Infant; Intestinal Mucosa / cytology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Prebiotics; Probiotics / pharmacology; Tight Junction Proteins / metabolism; Tight Junctions / metabolism; Toll-Like Receptors / metabolism
Sources: ORCID, Web Of Science, Crossref
Added: June 24, 2021
2020 article
A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia
Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 conference paper
A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia
Experimental Biology. San Diego, CA, USA.
Source: ORCID
Added: November 20, 2020
2020 conference paper
An age-dependent, rescuable defect in intestinal barrier repair is associated with an immature enteric glial network in a neonatal pig model of intestinal ischemia
Translational Science 2020. Washington, DC, USA.
Source: ORCID
Added: November 20, 2020
2020 article
Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair
Ziegler, A., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 conference paper
Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair
Experimental Biology. San Diego, CA, USA.
Source: ORCID
Added: November 20, 2020
2020 article
Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model
Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 conference paper
Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model.
Experimental Biology. San Diego, CA, USA.
Source: ORCID
Added: November 20, 2020
2020 journal article
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model
TISSUE BARRIERS, 8(4).
author keywords: Intestinal barrier; ischemia; stress; pig model; tight junctions
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / physiopathology; Ischemia / physiopathology; Permeability; Swine
Sources: ORCID, Web Of Science
Added: October 27, 2020
2020 conference paper
Multi-institutional retrospective case-control study evaluating clinical outcomes of foals with small intestinal strangulating obstruction: 2000-2019.
2020 American College of Veterinary Surgeons Surgery E-Summit. American College of Veterinary Surgeons Surgery E-Summit.
Source: ORCID
Added: November 20, 2020
2020 journal article
Sparing the gut: COX ‐2 inhibitors herald a new era for treatment of horses with surgical colic
Equine Veterinary Education, 10.
author keywords: horse; NSAIDs; COX-selective; colic; endotoxaemia; gut barrier
Source: ORCID
Added: October 5, 2019
2020 article
iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model
Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, ORCID
Added: October 12, 2020
2020 conference paper
iDISCO allows complete visualization and analysis of postnatal enteric nervous system development in a comparative pig model
Experimental Biology. San Diego, CA, USA.
Source: ORCID
Added: November 20, 2020
2019 journal article
Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?
Equine Veterinary Journal, 51(3), 423–423.
MeSH headings : 4-Butyrolactone / analogs & derivatives; Animals; Clonixin / analogs & derivatives; Horses; Sulfones
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2019
2019 conference paper
Rescue of Restitution Defect in a Neonatal Pig Intestinal Ischemia Model is associated with an Immature Enteric Glial Network
Digestive Disease Week. San Diego, CA, USA.
Source: ORCID
Added: November 20, 2020
2019 conference paper
Suckling piglets have a rescuable defect in intestinal barrier repair associated with an immature enteric glial network
Conference of Research Workers in Animal Disease. Chicago, IL, USA.
Source: ORCID
Added: November 20, 2020
2018 article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
Ziegler, A. L., Pridgen, T. A., Mills, J. K., Gonzalez, L. M., Landeghem, L. V., Odle, J., & Blikslager, A. T. (2018, July 3). (Vol. 7). Vol. 7.
Source: ORCID
Added: September 9, 2019
2018 journal article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
PLOS ONE, 13(8), e0200674.
Ed(s): J. Karhausen
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
Sources: ORCID, Web Of Science, Crossref
Added: October 16, 2018
2018 journal article
Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction
Equine Veterinary Journal, 51(3), 329–335.
author keywords: horse; colic; endotoxaemia; flunixin meglumine; firocoxib; clinical study
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Obstruction / complications; Intestinal Obstruction / veterinary; Male; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Random Allocation; Sulfones / administration & dosage; Sulfones / therapeutic use
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2019
2018 conference paper
Neonatal Defect in Subacute Barrier Repair is Rescued by Juvenile Mucosal Homogenate in a Pig Model of Intestinal Ischemia and Repair
National Veterinary Scholars Symposium, Aug 3. College Station, TX, USA.
Source: ORCID
Added: November 20, 2020
2018 conference paper
Randomized control trial comparing flunixin meglumine and firocoxib in equine strangulating obstruction
American Association of Equine Practitioners Convention. Oral Abstract: American Association of Equine Practitioners.
Source: ORCID
Added: November 20, 2020
2017 conference paper
Neonates have a reduced ability to repair jejunal mucosal injury as compared to weanlings in a porcine model of small intestinal strangulating obstruction
12th International Colic Research Symposium. Lexington, KY, USA.
Source: ORCID
Added: November 20, 2020
2017 conference paper
Neonates have reduced epithelial wound healing associated with fewer enteric glial cells as compared to juveniles in a pig model of intestinal ischemic injury and repair
FASEB Gastrointestinal Tract XVII. CO, USA.
Source: ORCID
Added: November 20, 2020
2017 conference paper
Randomized control trial comparing flunixin and firocoxib in equine strangulating obstruction
12th International Colic Research Symposium. Lexington, KY, USA.
Source: ORCID
Added: November 20, 2020
2017 journal article
Update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses
Journal of the American Veterinary Medical Association, 250(11), 1271–1274.
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Drug Compounding; Horse Diseases / drug therapy; Horses; Species Specificity; Sulfones / administration & dosage; Sulfones / therapeutic use; Veterinary Drugs
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018
2016 journal article
Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
Cellular and Molecular Gastroenterology and Hepatology, 2(6), 716–724.
author keywords: Pig; Ischemia/Reperfusion Injury; Mucosal Repair; Tight Junction
Sources: ORCID, Crossref
Added: July 20, 2019
2016 conference paper
Neonates Have a Reduced Ability to Repair Jejunal Mucosal Injury as Compared to Juveniles in a Pig Model of Ischemia/ Reperfusion Injury
Digestive Disease Week. San Diego, CA, USA.
Source: ORCID
Added: November 20, 2020
2015 journal article
Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts
Journal of Histochemistry & Cytochemistry, 64(2), 99–111.
MeSH headings : Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / pathology; Gene Expression Regulation; Gene Silencing; Humans; Idiopathic Pulmonary Fibrosis / genetics; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Lung / metabolism; Lung / pathology; Myocytes, Smooth Muscle / metabolism; Myofibroblasts / metabolism; Myofibroblasts / pathology; Proto-Oncogene Proteins / analysis; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Transforming Growth Factor beta / analysis; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Up-Regulation; Wnt Proteins / analysis; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt-5a Protein
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2013 conference paper
Porcine alveolar type II cells as a potential model for human alveolar epithelium in culture.
National Veterinary Scholars Symposium. Lansing, MI, USA.
Source: ORCID
Added: November 20, 2020
Employment
Updated: September 15th, 2019 16:23
2019 - present
North Carolina State University Ralaigh, NC, US
Research Assistant Professor
Clinical Sciences
2017 - 2019
University of North Carolina Chapel Hill, NC, US
Postdoctoral Trainee
Medicine
Education
Updated: September 16th, 2019 07:38
2017 - 2019
University of North Carolina Chapel Hill, NC, US
Postdoctoral Fellowship; Basic Science Gastroenterology
Medicine
2015 - 2018
North Carolina State University Raleigh, NC, US
Doctorate of Philosophy
Comparative Biomedical Sciences
2011 - 2015
North Carolina State University Raleigh, NC, US
Doctor of Veterinary Medicine
2008 - 2011
University of Delaware Newark, DE, US
B.S. Pre-veterinary Medicine and Animal Biosciences
Funding History
Funding history based on the linked ORCID record. Updated: November 19th, 2020 10:57
contract
November 1, 2019 - October 1, 2021
Postnatal Development of Intestinal Barrier Repair
National Institutes of Health Office of Research Infrastructure Programs
grant
August 15, 2019 - July 31, 2024
Postnatal development of intestinal barrier repair
Office of the Director
grant
August 15, 2019 - June 30, 2024
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
National Institute of Child Health and Human Development
grant
April 1, 2019 - March 31, 2022
Bioactive nutrients enhance intestinal neural networks and rescue mucosal repair in developing neonates
National Institute of Food and Agriculture
grant
August 1, 2017 - May 1, 2018
Characterization of glial cells network development and mechanisms of glial cell-mediated mucosal repair in a neonatal pig model of intestinal ischemia
North Carolina State University
grant
July 1, 2017 - June 30, 2019
Gastroenterology Research Training
National Institute of Diabetes and Digestive and Kidney Diseases
grant
July 1, 2017 - May 1, 2018
Mechanisms of glial-mediated mucosal barrier repair in a neonatal pig model of intestinal ischemia
College of Veterinary Medicine, North Carolina State University
salary-award
January 1 - December 1, 2016
Randomized control trial comparing flunixin and firocoxib in equine strangulating obstruction
Grayson-Jockey Club Research Foundation
grant
September 1, 1985 - November 30, 2024
Center for Gastrointestinal Biology and Disease
National Institute of Diabetes and Digestive and Kidney Diseases
