Works (39)

Updated: April 4th, 2024 16:14

2024 journal article

Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period

American Journal of Physiology-Gastrointestinal and Liver Physiology.

By: A. Ziegler n, M. Caldwell n, S. Craig, E. Hellstrom n, A. Sheridan n, M. Touvron n, T. Pridgen n, S. Magness* ...

TL;DR: A neonatal phenotype characterized by a complete lack of coordinated reparative signaling in the mucosal microenvironment is confirmed and important evidence is reported that the subepithelial EGC network changes significantly over the early postnatal period and that proximity of a specific functional population of EGC to wounded intestinal epithelium contributes to intestinal barrier restitution following ischemic injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 12, 2024

2023 article

Effects of Prebiotic Galactooligosaccharide (GOS) on Hindgut Microbial Composition of Pigs During the Peri-Weaning Period

Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 187–188.

By: T. Boston n, F. Wang n, L. Xi, S. Kim n, V. Fellner n, M. Scott, A. Ziegler n, L. Van Landeghem n, A. Blikslager n, J. Odle n

author keywords: microbiome; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 article

Effects of Prebiotic Galactooligosaccharide (Gos) on Piglet Growth and Jejunal Morphology During the Peri-Weaning Period

Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, October 28). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 276–277.

By: T. Boston n, F. Wang n, L. Xi, S. Kim n, V. Fellner n, M. Scott, A. Ziegler n, L. Van Landeghem n, A. Blikslager n, J. Odle n

author keywords: intestinal villi; galactooligosaccharides; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 journal article

Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.

By: K. Rivera n, R. Bilton, J. Burclaff n, M. Czerwinski*, J. Liu*, J. Trueblood*, C. Hinesley*, K. Breau* ...

author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR: A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023

2022 article

Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period

Ziegler, A. L., Erwin, S., Caldwell, M. L., Touvron, M. S., Pridgen, T. A., Magness, S. T., … Blikslager, A. T. (2022, November 4).

TL;DR: It is suggested that targeting the enteric glial network could lead to novel interventions to improve recovery from intestinal injury in neonatal patients and demonstrate that EGC function in close proximity to wounded intestinal epithelium is critical to intestinal barrier restitution following ischemic injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: November 5, 2022

2022 article

Mechanisms and modeling of wound repair in the intestinal epithelium

Boger, K. D., Sheridan, A. E., Ziegler, A. L., & Blikslager, A. T. (2022, June 13). TISSUE BARRIERS, Vol. 6.

By: K. Boger n, A. Sheridan n, A. Ziegler n & A. Blikslager n

author keywords: IPEC-J2 cells; transepithelial electrical resistance; injury barrier function; cell model
MeSH headings : Humans; Caco-2 Cells; Intestinal Mucosa / metabolism; Intestines; Ischemia
TL;DR: This review focuses on in vitro injury models and intestinal cell lines utilized in such systems and the use of intestine cell lines, IPEC-J2, Caco-2, T-84, HT-29, and IEC-6, to model intestinal epithelium. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 12, 2022

2022 journal article

Multi-Institutional Retrospective Case-Control Study Evaluating Clinical Outcomes of Foals with Small Intestinal Strangulating Obstruction: 2000-2020

ANIMALS, 12(11).

By: S. Erwin n, M. Clark n, J. Dechant*, M. Aitken*, D. Hassel*, A. Blikslager n, A. Ziegler n

author keywords: horse; colic; foal; ischemia; small intestinal strangulating obstruction; surgery
TL;DR: Unexpectedly, short-term survival tended to be higher in foals than adults and may have been partly driven by case selection prior to referral or surgery or decision-making intraoperatively, and more optimism toward surgical treatment of foals with suspected SISO may be warranted. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 28, 2022

2022 review

Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 9.

By: E. Rose n, A. Blikslager n & A. Ziegler n

author keywords: intestinal microbiota; translational models; pig models; gut commensals; gastrointestinal disease
TL;DR: To further elucidate the pathogenesis of these disease syndromes as well as uncover novel therapies and preventative measures, gastrointestinal researchers should consider the pig as a powerful, translational model of the gastrointestinal microbiota. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2021 journal article

Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic

ANIMALS, 11(12).

By: S. Erwin n, A. Blikslager n & A. Ziegler n

author keywords: horse; colic; ischemia-reperfusion injury; intestinal barrier repair; enteric nervous system; enteric glial cells; tight junction proteins
TL;DR: The current understanding of the roles of the gut microbiome, nutrition, stress, and the ENS in maturation of intestinal repair mechanisms after foaling is reviewed and how this may influence age-dependent outcomes in equine colic cases is reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 25, 2021

2021 review

Postoperative Ileus: Comparative Pathophysiology and Future Therapies

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 8.

By: E. Hellstrom n, A. Ziegler n & A. Blikslager n

author keywords: intestine; equine; surgery; barrier function; enteric glia and neurons; microbiota
TL;DR: Understanding of the roles of the gastrointestinal microbiota, intestinal barrier function, the post-surgical inflammatory response, as well as enteric glial cells, a component of the enteric nervous system, in modulating postoperative gastrointestinal motility and the pathogenesis of POI may provide future targets for prevention and/or therapy ofPOI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2021

2021 journal article

Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

International Journal of Molecular Sciences, 22(13), 6729.

By: E. Rose n, J. Odle n, A. Blikslager n & A. Ziegler n

author keywords: probiotics; prebiotics; bioactive compounds; intestinal barrier function; tight junctions; toll-like receptors; intestinal microbiota
MeSH headings : Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Humans; Infant; Intestinal Mucosa / cytology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Prebiotics; Probiotics / pharmacology; Tight Junction Proteins / metabolism; Tight Junctions / metabolism; Toll-Like Receptors / metabolism
TL;DR: Current views on the effects of pro- and prebiotics on the intestinal epithelial barrier as well as on non-epithelial cell barrier constituents, such as the enteric glial cell network are summarized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: June 24, 2021

2020 article

A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia

Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. Sheridan*, T. Pridgen*, J. Odle*, L. Van Landeghem*, A. Blikslager* & A. Ziegler*

TL;DR: It is hypothesized that EGC inhibition in juveniles will block epithelial barrier repair after ischemic injury mimicking the neonatal phenotype, and the development of glial‐epithelial crosstalk in barrier repair will ultimately guide novel clinical solutions to improve outcomes in neonatal patients affected by intestinal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020

2020 conference paper

A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia

Experimental Biology. San Diego, CA, USA.

By: A. Sheridan, T. Pridgen, J. Odle, L. Landeghem, A. Blikslager & A. Ziegler

Source: ORCID
Added: November 20, 2020

2020 conference paper

An age-dependent, rescuable defect in intestinal barrier repair is associated with an immature enteric glial network in a neonatal pig model of intestinal ischemia

Translational Science 2020. Washington, DC, USA.

By: A. Ziegler, A. Sheridan, T. Pridgen, J. Odle, L. Landeghem & A. Blikslager

Source: ORCID
Added: November 20, 2020

2020 article

Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair

Ziegler, A., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. Ziegler n & A. Blikslager n

TL;DR: The results indicate that acute transport stress on the day of experimental intestinal injury modeling may increase mucosal susceptibility to epithelial loss, but also prime the tissue for a more robust barrier repair response. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 conference paper

Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair

Experimental Biology. San Diego, CA, USA.

By: A. Ziegler & A. Blikslager

Source: ORCID
Added: November 20, 2020

2020 article

Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model

Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: L. Shapiro n, A. Ziegler n, J. Odle n, L. Van Landeghem n & A. Blikslager n

TL;DR: Test the effects of dietary oligosaccharides on postnatal changes in the EGC network and intestinal morphology in a neonatal pig model to find increased mucosal expression of EGC markers earlier in postnatal development in the high oligOSaccharide group, as well as histological changes consistent with enhanced rates of gut maturation in pigs fed a high oligosACcharide diet. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020

2020 conference paper

Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model.

Experimental Biology. San Diego, CA, USA.

By: L. Shapiro, A. Ziegler, J. Odle, L. Landeghem & A. Blikslager

Source: ORCID
Added: November 20, 2020

2020 journal article

Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model

TISSUE BARRIERS, 8(4).

By: A. Ziegler n, T. Pridgen n & A. Blikslager n

author keywords: Intestinal barrier; ischemia; stress; pig model; tight junctions
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / physiopathology; Ischemia / physiopathology; Permeability; Swine
TL;DR: The effects of a period of environmental acclimation versus acute transport stress on mucosal barrier repair after intestinal ischemic injury and recovery are reported. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 27, 2020

2020 conference paper

Multi-institutional retrospective case-control study evaluating clinical outcomes of foals with small intestinal strangulating obstruction: 2000-2019.

2020 American College of Veterinary Surgeons Surgery E-Summit. American College of Veterinary Surgeons Surgery E-Summit.

By: S. Erwin, J. Dechant, M. Aitken, D. Hassel, A. Ziegler & A. Blikslager

Source: ORCID
Added: November 20, 2020

2020 journal article

Sparing the gut: COX‐2 inhibitors herald a new era for treatment of horses with surgical colic

Equine Veterinary Education.

By: A. Ziegler n & A. Blikslager n

author keywords: horse; NSAIDs; COX-selective; colic; endotoxaemia; gut barrier
TL;DR: Emerging research suggests that firocoxib, a COX-2-selective NSAID labelled for use in horses, may be preferable forUse in colic cases in spite of the decades-long dogma that flunixin saves lives. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: October 5, 2019

2020 article

iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model

Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: S. Erwin n, M. Touvron*, J. Odle n, L. Van Landeghem n, A. Blikslager n & A. Ziegler n

Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020

2020 conference paper

iDISCO allows complete visualization and analysis of postnatal enteric nervous system development in a comparative pig model

Experimental Biology. San Diego, CA, USA.

By: S. Erwin, M. Touvron, J. Odle, L. Landeghem, A. Blikslager & A. Ziegler

Source: ORCID
Added: November 20, 2020

2019 journal article

Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?

Equine Veterinary Journal, 51(3), 423–423.

By: A. Ziegler n, C. Fogle n, M. Burke n & A. Blikslager n

MeSH headings : 4-Butyrolactone / analogs & derivatives; Animals; Clonixin / analogs & derivatives; Horses; Sulfones
TL;DR: It is proposed that validating a trend towards improved survival in horses treated with firocoxib would require additional studies with greater numbers of horses and likely modification of the study design to include preoperative drug randomisation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 6, 2019

2019 conference paper

Rescue of Restitution Defect in a Neonatal Pig Intestinal Ischemia Model is associated with an Immature Enteric Glial Network

Digestive Disease Week. San Diego, CA, USA.

By: A. Ziegler, T. Pridgen, L. Landeghem, J. Odle, S. Magness & A. Blikslager

Source: ORCID
Added: November 20, 2020

2019 conference paper

Suckling piglets have a rescuable defect in intestinal barrier repair associated with an immature enteric glial network

Conference of Research Workers in Animal Disease. Chicago, IL, USA.

By: A. Ziegler, T. Pridgen, L. Landeghem, J. Odle, S. Magness & A. Blikslager

Source: ORCID
Added: November 20, 2020

2018 article

Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair

Ziegler, A. L., Pridgen, T. A., Mills, J. K., Gonzalez, L. M., Landeghem, L. V., Odle, J., & Blikslager, A. T. (2018, July 3). (Vol. 7). Vol. 7.

By: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Landeghem n, J. Odle n, A. Blikslager n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 9, 2019

2018 journal article

Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair

PLOS ONE, 13(8), e0200674.

By: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Contributors: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Ed(s): J. Karhausen

MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR: Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution. (via Semantic Scholar)
Sources: ORCID, Web Of Science, Crossref, NC State University Libraries
Added: October 16, 2018

2018 journal article

Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction

Equine Veterinary Journal, 51(3), 329–335.

By: A. Ziegler n, C. Freeman n, C. Fogle n, M. Burke n, J. Davis*, V. Cook*, L. Southwood*, A. Blikslager n

author keywords: horse; colic; endotoxaemia; flunixin meglumine; firocoxib; clinical study
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Obstruction / complications; Intestinal Obstruction / veterinary; Male; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Random Allocation; Sulfones / administration & dosage; Sulfones / therapeutic use
TL;DR: Treatment of post-surgical SISO horses with firocoxib (COX-2 selective) would reduce the signs of endotoxaemia to a greater extent than flunixin meglumine (nonselective COX inhibitor) while continuing to provide similar levels of pain control. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 6, 2019

2018 conference paper

Neonatal Defect in Subacute Barrier Repair is Rescued by Juvenile Mucosal Homogenate in a Pig Model of Intestinal Ischemia and Repair

National Veterinary Scholars Symposium, Aug 3. College Station, TX, USA.

By: A. Ziegler, T. Pridgen, L. Landeghem, L. Gonzalez, J. Odle & A. Blikslager

Source: ORCID
Added: November 20, 2020

2018 conference paper

Randomized control trial comparing flunixin meglumine and firocoxib in equine strangulating obstruction

American Association of Equine Practitioners Convention. Oral Abstract: American Association of Equine Practitioners.

By: A. Ziegler, C. Freeman, C. Fogle, M. Burke, J. Davis, L. Southwood, V. Cook, A. Blikslager

Source: ORCID
Added: November 20, 2020

2017 conference paper

Neonates have a reduced ability to repair jejunal mucosal injury as compared to weanlings in a porcine model of small intestinal strangulating obstruction

12th International Colic Research Symposium. Lexington, KY, USA.

By: A. Ziegler, T. Pridgen, L. Landeghem, L. Gonzalez, J. Odle & A. Blikslager

Source: ORCID
Added: November 20, 2020

2017 conference paper

Neonates have reduced epithelial wound healing associated with fewer enteric glial cells as compared to juveniles in a pig model of intestinal ischemic injury and repair

FASEB Gastrointestinal Tract XVII. CO, USA.

By: A. Ziegler, T. Pridgen, L. Landeghem, L. Gonzalez, J. Odle & A. Blikslager

Source: ORCID
Added: November 20, 2020

2017 conference paper

Randomized control trial comparing flunixin and firocoxib in equine strangulating obstruction

12th International Colic Research Symposium. Lexington, KY, USA.

By: A. Ziegler, C. Fogle, M. Burke, J. Davis, L. Southwood, V. Cook, A. Blikslager

Source: ORCID
Added: November 20, 2020

2017 journal article

Update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses

Journal of the American Veterinary Medical Association, 250(11), 1271–1274.

By: A. Ziegler*, C. Fogle* & A. Blikslager*

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Drug Compounding; Horse Diseases / drug therapy; Horses; Species Specificity; Sulfones / administration & dosage; Sulfones / therapeutic use; Veterinary Drugs
TL;DR: Understanding the nuances of firocoxib administration, including the importance of correct dosing and the contraindications of combining NSAIDs, and knowledge of the potential advantages of COX-2 selectivity will help veterinarians select and treat patients that could benefit from this new class of NSAID. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Large Animal Models: The Key to Translational Discovery in Digestive Disease Research

Cellular and Molecular Gastroenterology and Hepatology, 2(6), 716–724.

By: A. Ziegler n, L. Gonzalez n & A. Blikslager n

author keywords: Pig; Ischemia/Reperfusion Injury; Mucosal Repair; Tight Junction
TL;DR: Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access, and cellular tools are providing the methodology to translate basic science findings using in-depth mechanistic analyses, holding great promise for the future of clinically relevant digestive disease research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: July 20, 2019

2016 conference paper

Neonates Have a Reduced Ability to Repair Jejunal Mucosal Injury as Compared to Juveniles in a Pig Model of Ischemia/ Reperfusion Injury

Digestive Disease Week. San Diego, CA, USA.

By: A. Ziegler, T. Pridgen, G. Carnighan, J. Odle, L. Gonzalez & A. Blikslager

Source: ORCID
Added: November 20, 2020

2015 journal article

Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts

Journal of Histochemistry & Cytochemistry, 64(2), 99–111.

By: D. Newman n, W. Sills n, K. Hanrahan n, A. Ziegler n, K. Tidd n, E. Cook n, P. Sannes n

MeSH headings : Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / pathology; Gene Expression Regulation; Gene Silencing; Humans; Idiopathic Pulmonary Fibrosis / genetics; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Lung / metabolism; Lung / pathology; Myocytes, Smooth Muscle / metabolism; Myofibroblasts / metabolism; Myofibroblasts / pathology; Proto-Oncogene Proteins / analysis; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Transforming Growth Factor beta / analysis; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Up-Regulation; Wnt Proteins / analysis; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt-5a Protein
TL;DR: A wide distribution of Wnt5A expression in cells of the IPF lung is demonstrated and it is revealed that it is significantly increased by Wnt7B and TGF-β1, which, in combination, could represent key signaling pathways that modulate the pathogenesis of IPF. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2013 conference paper

Porcine alveolar type II cells as a potential model for human alveolar epithelium in culture.

National Veterinary Scholars Symposium. Lansing, MI, USA.

By: A. Welch, D. Newman & P. Sannes

Source: ORCID
Added: November 20, 2020

Employment

Updated: September 15th, 2019 16:23

2019 - present

North Carolina State University Ralaigh, NC, US
Research Assistant Professor Clinical Sciences

2017 - 2019

University of North Carolina Chapel Hill, NC, US
Postdoctoral Trainee Medicine

Education

Updated: September 16th, 2019 07:38

2017 - 2019

University of North Carolina Chapel Hill, NC, US
Postdoctoral Fellowship; Basic Science Gastroenterology Medicine

2015 - 2018

North Carolina State University Raleigh, NC, US
Doctorate of Philosophy Comparative Biomedical Sciences

2011 - 2015

North Carolina State University Raleigh, NC, US
Doctor of Veterinary Medicine

2008 - 2011

University of Delaware Newark, DE, US
B.S. Pre-veterinary Medicine and Animal Biosciences

Funding History

Funding history based on the linked ORCID record. Updated: November 19th, 2020 10:57

contract November 1, 2019 - October 1, 2021
Postnatal Development of Intestinal Barrier Repair
National Institutes of Health Office of Research Infrastructure Programs
grant August 15, 2019 - July 31, 2024
Postnatal development of intestinal barrier repair
Office of the Director
grant August 15, 2019 - June 30, 2024
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestine
National Institute of Child Health and Human Development
grant April 1, 2019 - March 31, 2022
Bioactive nutrients enhance intestinal neural networks and rescue mucosal repair in developing neonates
National Institute of Food and Agriculture
grant August 1, 2017 - May 1, 2018
Characterization of glial cells network development and mechanisms of glial cell-mediated mucosal repair in a neonatal pig model of intestinal ischemia
North Carolina State University
grant July 1, 2017 - June 30, 2019
Gastroenterology Research Training
National Institute of Diabetes and Digestive and Kidney Diseases
grant July 1, 2017 - May 1, 2018
Mechanisms of glial-mediated mucosal barrier repair in a neonatal pig model of intestinal ischemia
College of Veterinary Medicine, North Carolina State University
salary-award January 1 - December 1, 2016
Randomized control trial comparing flunixin and firocoxib in equine strangulating obstruction
Grayson-Jockey Club Research Foundation
grant September 1, 1985 - November 30, 2024
Center for Gastrointestinal Biology and Disease
National Institute of Diabetes and Digestive and Kidney Diseases

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