@article{ziegler_erwin_caldwell_touvron_pridgen_magness_odle_landeghem_blikslager_2022, title={Enteric Glial Cell Network Function is Required for Epithelial Barrier Restitution following Intestinal Ischemic Injury in the Early Postnatal Period}, url={https://doi.org/10.1101/2022.11.04.514575}, DOI={10.1101/2022.11.04.514575}, author={Ziegler, Amanda L. and Erwin, Sara and Caldwell, Madison L. and Touvron, Melissa S. and Pridgen, Tiffany A. and Magness, Scott T. and Odle, Jack and Landeghem, Laurianne Van and Blikslager, Anthony T.}, year={2022}, month={Nov} } @article{boger_sheridan_ziegler_blikslager_2022, title={Mechanisms and modeling of wound repair in the intestinal epithelium}, volume={6}, ISSN={["2168-8370"]}, url={https://doi.org/10.1080/21688370.2022.2087454}, DOI={10.1080/21688370.2022.2087454}, journal={TISSUE BARRIERS}, author={Boger, Kasey D. and Sheridan, Ana E. and Ziegler, Amanda L. and Blikslager, Anthony T.}, year={2022}, month={Jun} } @article{erwin_clark_dechant_aitken_hassel_blikslager_ziegler_2022, title={Multi-Institutional Retrospective Case-Control Study Evaluating Clinical Outcomes of Foals with Small Intestinal Strangulating Obstruction: 2000-2020}, volume={12}, ISSN={["2076-2615"]}, url={https://doi.org/10.3390/ani12111374}, DOI={10.3390/ani12111374}, number={11}, journal={ANIMALS}, publisher={MDPI AG}, author={Erwin, Sara J. and Clark, Marley E. and Dechant, Julie E. and Aitken, Maia R. and Hassel, Diana M. and Blikslager, Anthony T. and Ziegler, Amanda L.}, year={2022}, month={Jun} } @misc{rose_blikslager_ziegler_2022, title={Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease}, volume={9}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2022.834598}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Rose, Elizabeth C. and Blikslager, Anthony T. and Ziegler, Amanda L.}, year={2022}, month={Mar} } @article{erwin_blikslager_ziegler_2021, title={Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic}, volume={11}, ISSN={["2076-2615"]}, url={https://doi.org/10.3390/ani11123337}, DOI={10.3390/ani11123337}, number={12}, journal={ANIMALS}, author={Erwin, Sara J. and Blikslager, Anthony T. and Ziegler, Amanda L.}, year={2021}, month={Dec} } @misc{hellstrom_ziegler_blikslager_2021, title={Postoperative Ileus: Comparative Pathophysiology and Future Therapies}, volume={8}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2021.714800}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Hellstrom, Emily A. and Ziegler, Amanda L. and Blikslager, Anthony T.}, year={2021}, month={Sep} } @article{rose_odle_blikslager_ziegler_2021, title={Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function}, volume={22}, ISSN={1422-0067}, url={http://dx.doi.org/10.3390/ijms22136729}, DOI={10.3390/ijms22136729}, abstractNote={Disruptions in the intestinal epithelial barrier can result in devastating consequences and a multitude of disease syndromes, particularly among preterm neonates. The association between barrier dysfunction and intestinal dysbiosis suggests that the intestinal barrier function is interactive with specific gut commensals and pathogenic microbes. In vitro and in vivo studies demonstrate that probiotic supplementation promotes significant upregulation and relocalization of interepithelial tight junction proteins, which form the microscopic scaffolds of the intestinal barrier. Probiotics facilitate some of these effects through the ligand-mediated stimulation of several toll-like receptors that are expressed by the intestinal epithelium. In particular, bacterial-mediated stimulation of toll-like receptor-2 modulates the expression and localization of specific protein constituents of intestinal tight junctions. Given that ingested prebiotics are robust modulators of the intestinal microbiota, prebiotic supplementation has been similarly investigated as a potential, indirect mechanism of barrier preservation. Emerging evidence suggests that prebiotics may additionally exert a direct effect on intestinal barrier function through mechanisms independent of the gut microbiota. In this review, we summarize current views on the effects of pro- and prebiotics on the intestinal epithelial barrier as well as on non-epithelial cell barrier constituents, such as the enteric glial cell network. Through continued investigation of these bioactive compounds, we can maximize their therapeutic potential for preventing and treating gastrointestinal diseases associated with impaired intestinal barrier function and dysbiosis.}, number={13}, journal={International Journal of Molecular Sciences}, publisher={MDPI AG}, author={Rose, Elizabeth C. and Odle, Jack and Blikslager, Anthony T. and Ziegler, Amanda L.}, year={2021}, month={Jun}, pages={6729} } @article{sheridan_pridgen_odle_van landeghem_blikslager_ziegler_2020, title={A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia}, volume={34}, ISSN={["1530-6860"]}, DOI={10.1096/fasebj.2020.34.s1.02030}, number={S1}, journal={FASEB JOURNAL}, publisher={Wiley}, author={Sheridan, Ana and Pridgen, Tiffany and Odle, Jack and Van Landeghem, Laurianne and Blikslager, Anthony and Ziegler, Amanda}, year={2020}, month={Apr} } @inproceedings{sheridan_pridgen_odle_landeghem_blikslager_ziegler_2020, place={San Diego, CA, USA}, title={A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia}, booktitle={Experimental Biology}, author={Sheridan, A.E. and Pridgen, T.A. and Odle, J. and Landeghem, L.Van and Blikslager, A.T. and Ziegler, A.L.}, year={2020}, month={Apr} } @inproceedings{ziegler_sheridan_pridgen_odle_landeghem_blikslager_2020, place={Washington, DC, USA}, title={An age-dependent, rescuable defect in intestinal barrier repair is associated with an immature enteric glial network in a neonatal pig model of intestinal ischemia}, booktitle={Translational Science 2020}, author={Ziegler, A.L. and Sheridan, A.E. and Pridgen, T.A. and Odle, J. and Landeghem, LVan and Blikslager, A.T.}, year={2020}, month={Apr} } @article{ziegler_blikslager_2020, title={Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair}, volume={34}, ISSN={["1530-6860"]}, DOI={10.1096/fasebj.2020.34.s1.09380}, journal={FASEB JOURNAL}, author={Ziegler, Amanda and Blikslager, Anthony}, year={2020}, month={Apr} } @inproceedings{ziegler_blikslager_2020, place={San Diego, CA, USA}, title={Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair}, booktitle={Experimental Biology}, author={Ziegler, A.L. and Blikslager, A.T.}, year={2020}, month={Apr} } @article{shapiro_ziegler_odle_van landeghem_blikslager_2020, title={Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model}, volume={34}, ISSN={["1530-6860"]}, DOI={10.1096/fasebj.2020.34.s1.09457}, number={S1}, journal={FASEB JOURNAL}, publisher={Wiley}, author={Shapiro, Lindsey and Ziegler, Amanda and Odle, Jack and Van Landeghem, Laurianne and Blikslager, Anthony}, year={2020}, month={Apr} } @inproceedings{shapiro_ziegler_odle_landeghem_blikslager_2020, place={San Diego, CA, USA}, title={Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model. }, booktitle={Experimental Biology}, author={Shapiro, L. and Ziegler, A.L. and Odle, J. and Landeghem, L.Van and Blikslager, A.T.}, year={2020}, month={Apr} } @article{ziegler_pridgen_blikslager_2020, title={Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model}, volume={8}, ISSN={["2168-8370"]}, url={https://doi.org/10.1080/21688370.2020.1832421}, DOI={10.1080/21688370.2020.1832421}, number={4}, journal={TISSUE BARRIERS}, publisher={Informa UK Limited}, author={Ziegler, Amanda L. and Pridgen, Tiffany A. and Blikslager, Anthony T.}, year={2020}, month={Oct} } @inproceedings{erwin_dechant_aitken_hassel_ziegler_blikslager_2020, title={Multi-institutional retrospective case-control study evaluating clinical outcomes of foals with small intestinal strangulating obstruction: 2000-2019. }, booktitle={2020 American College of Veterinary Surgeons Surgery E-Summit}, publisher={American College of Veterinary Surgeons Surgery E-Summit}, author={Erwin, S.J. and Dechant, J.E. and Aitken, M.R. and Hassel, D.M. and Ziegler, A.L. and Blikslager, A.T.}, year={2020}, month={Oct} } @article{ziegler_blikslager_2020, title={Sparing the gut: COX ‐2 inhibitors herald a new era for treatment of horses with surgical colic}, volume={10}, url={https://doi.org/10.1111/eve.13189}, DOI={10.1111/eve.13189}, journal={Equine Veterinary Education}, publisher={Wiley}, author={Ziegler, A. L. and Blikslager, A. T.}, year={2020}, month={Nov} } @article{erwin_touvron_odle_van landeghem_blikslager_ziegler_2020, title={iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model}, volume={34}, ISSN={["1530-6860"]}, DOI={10.1096/fasebj.2020.34.s1.03991}, number={S1}, journal={FASEB JOURNAL}, publisher={Wiley}, author={Erwin, Sara and Touvron, Melissa and Odle, Jack and Van Landeghem, Laurianne and Blikslager, Anthony and Ziegler, Amanda}, year={2020}, month={Apr} } @inproceedings{erwin_touvron_odle_landeghem_blikslager_ziegler_2020, place={San Diego, CA, USA}, title={iDISCO allows complete visualization and analysis of postnatal enteric nervous system development in a comparative pig model}, booktitle={Experimental Biology}, author={Erwin, S.E. and Touvron, M. and Odle, J. and Landeghem, L.Van and Blikslager, A.T. and Ziegler, A.L.}, year={2020}, month={Apr} } @article{ziegler_fogle_burke_blikslager_2019, title={Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?}, volume={51}, ISSN={0425-1644 2042-3306}, url={http://dx.doi.org/10.1111/evj.13081}, DOI={10.1111/evj.13081}, number={3}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Ziegler, A. L. and Fogle, C. A. and Burke, M. and Blikslager, A. T.}, year={2019}, month={Feb}, pages={423–423} } @inproceedings{ziegler_pridgen_landeghem_odle_magness_blikslager_2019, place={San Diego, CA, USA}, title={Rescue of Restitution Defect in a Neonatal Pig Intestinal Ischemia Model is associated with an Immature Enteric Glial Network}, booktitle={Digestive Disease Week}, author={Ziegler, A.L. and Pridgen, T.A. and Landeghem, L.Van and Odle, J. and Magness, S.T. and Blikslager, A.T.}, year={2019}, month={May} } @inproceedings{ziegler_pridgen_landeghem_odle_magness_blikslager_2019, place={Chicago, IL, USA}, title={Suckling piglets have a rescuable defect in intestinal barrier repair associated with an immature enteric glial network}, booktitle={Conference of Research Workers in Animal Disease}, author={Ziegler, A.L. and Pridgen, T.A. and Landeghem, L.Van and Odle, J. and Magness, S.T. and Blikslager, A.T.}, year={2019}, month={Nov} } @article{ziegler_pridgen_mills_gonzalez_landeghem_odle_blikslager_2018, title={Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair}, volume={7}, url={https://doi.org/10.1101/361352}, DOI={10.1101/361352}, publisher={Cold Spring Harbor Laboratory}, author={Ziegler, Amanda L. and Pridgen, Tiffany A. and Mills, Juliana K. and Gonzalez, Liara M. and Landeghem, Laurianne Van and Odle, Jack and Blikslager, Anthony T.}, year={2018}, month={Jul} } @article{ziegler_pridgen_mills_gonzalez_van landeghem_odle_blikslager_2018, title={Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair}, volume={13}, ISSN={1932-6203}, url={http://dx.doi.org/10.1371/journal.pone.0200674}, DOI={10.1371/journal.pone.0200674}, number={8}, journal={PLOS ONE}, publisher={Public Library of Science (PLoS)}, author={Ziegler, Amanda L. and Pridgen, Tiffany A. and Mills, Juliana K. and Gonzalez, Liara M. and Van Landeghem, Laurianne and Odle, Jack and Blikslager, Anthony T.}, editor={Karhausen, JörnEditor}, year={2018}, month={Aug}, pages={e0200674} } @article{ziegler_freeman_fogle_burke_davis_cook_southwood_blikslager_2018, title={Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction}, volume={51}, ISSN={0425-1644 2042-3306}, url={http://dx.doi.org/10.1111/evj.13013}, DOI={10.1111/evj.13013}, number={3}, journal={Equine Veterinary Journal}, publisher={Wiley}, author={Ziegler, A. L. and Freeman, C. K. and Fogle, C. A. and Burke, M. J. and Davis, J. L. and Cook, V. L. and Southwood, L. L. and Blikslager, A. T.}, year={2018}, month={Sep}, pages={329–335} } @inproceedings{ziegler_pridgen_landeghem_gonzalez_odle_blikslager_2018, place={College Station, TX, USA}, title={Neonatal Defect in Subacute Barrier Repair is Rescued by Juvenile Mucosal Homogenate in a Pig Model of Intestinal Ischemia and Repair}, volume={Aug 3}, booktitle={National Veterinary Scholars Symposium}, author={Ziegler, A.L. and Pridgen, T.A. and Landeghem, L.Van and Gonzalez, L.M. and Odle, J. and Blikslager, A.T.}, year={2018}, month={Aug} } @inproceedings{ziegler_freeman_fogle_burke_davis_southwood_cook_blikslager_2018, place={Oral Abstract}, title={Randomized control trial comparing flunixin meglumine and firocoxib in equine strangulating obstruction}, booktitle={American Association of Equine Practitioners Convention}, publisher={American Association of Equine Practitioners}, author={Ziegler, A.L. and Freeman, C.K. and Fogle, C.A. and Burke, M.J. and Davis, J. and Southwood, L.L. and Cook, V.L. and Blikslager, A.T.}, year={2018}, month={Dec} } @inproceedings{ziegler_pridgen_landeghem_gonzalez_odle_blikslager_2017, place={Lexington, KY, USA}, title={Neonates have a reduced ability to repair jejunal mucosal injury as compared to weanlings in a porcine model of small intestinal strangulating obstruction}, booktitle={12th International Colic Research Symposium}, author={Ziegler, A.L. and Pridgen, T.A. and Landeghem, L.Van and Gonzalez, L.M. and Odle, J. and Blikslager, A.T.}, year={2017}, month={Jul} } @inproceedings{ziegler_pridgen_landeghem_gonzalez_odle_blikslager_2017, place={CO, USA}, title={Neonates have reduced epithelial wound healing associated with fewer enteric glial cells as compared to juveniles in a pig model of intestinal ischemic injury and repair}, booktitle={FASEB Gastrointestinal Tract XVII}, author={Ziegler, A.L. and Pridgen, T.A. and Landeghem, L.Van and Gonzalez, L.M. and Odle, J. and Blikslager, A.T.}, year={2017}, month={Jul} } @inproceedings{ziegler_fogle_burke_davis_southwood_cook_blikslager_2017, place={Lexington, KY, USA}, title={Randomized control trial comparing flunixin and firocoxib in equine strangulating obstruction}, booktitle={12th International Colic Research Symposium}, author={Ziegler, A.L. and Fogle, C. and Burke, M. and Davis, J. and Southwood, L. and Cook, V. and Blikslager, A.T.}, year={2017}, month={Jul} } @article{ziegler_fogle_blikslager_2017, title={Update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses}, volume={250}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.250.11.1271}, DOI={10.2460/javma.250.11.1271}, number={11}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Ziegler, Amanda and Fogle, Callie and Blikslager, Anthony}, year={2017}, month={Jun}, pages={1271–1274} } @article{ziegler_gonzalez_blikslager_2016, title={Large Animal Models: The Key to Translational Discovery in Digestive Disease Research}, volume={2}, ISSN={2352-345X}, url={http://dx.doi.org/10.1016/j.jcmgh.2016.09.003}, DOI={10.1016/j.jcmgh.2016.09.003}, number={6}, journal={Cellular and Molecular Gastroenterology and Hepatology}, publisher={Elsevier BV}, author={Ziegler, Amanda and Gonzalez, Liara and Blikslager, Anthony}, year={2016}, month={Nov}, pages={716–724} } @inproceedings{ziegler_pridgen_carnighan_odle_gonzalez_blikslager_2016, place={San Diego, CA, USA}, title={Neonates Have a Reduced Ability to Repair Jejunal Mucosal Injury as Compared to Juveniles in a Pig Model of Ischemia/ Reperfusion Injury}, booktitle={Digestive Disease Week}, author={Ziegler, A.L. and Pridgen, T.A. and Carnighan, G. and Odle, J. and Gonzalez, L.M. and Blikslager, A.T.}, year={2016}, month={May} } @article{newman_sills_hanrahan_ziegler_tidd_cook_sannes_2015, title={Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts}, volume={64}, ISSN={0022-1554 1551-5044}, url={http://dx.doi.org/10.1369/0022155415617988}, DOI={10.1369/0022155415617988}, number={2}, journal={Journal of Histochemistry & Cytochemistry}, publisher={SAGE Publications}, author={Newman, Donna R. and Sills, W. Shane and Hanrahan, Katherine and Ziegler, Amanda and Tidd, Kathleen McGinnis and Cook, Elizabeth and Sannes, Philip L.}, year={2015}, month={Nov}, pages={99–111} } @inproceedings{welch_newman_sannes_2013, place={Lansing, MI, USA}, title={Porcine alveolar type II cells as a potential model for human alveolar epithelium in culture.}, booktitle={National Veterinary Scholars Symposium}, author={Welch, A.L. and Newman, D.R. and Sannes, P.L.}, year={2013}, month={Aug} }