Avanika Mahajan

Works (5)

Updated: July 25th, 2023 21:16

2011 journal article

Dietary Calcium Restriction Affects Mesenchymal Stem Cell Activity and Bone Development in Neonatal Pigs

JOURNAL OF NUTRITION, 141(3), 373–379.

By: A. Mahajan n, L. Alexander n, B. Seabolt n, D. Catrambone*, J. McClung *, J. Odle n , T. Pfeiler n, E. Loboa n, C. Stahl n

Contributors: A. Mahajan n, L. Alexander n, B. Seabolt n, D. Catrambone*, J. McClung *, J. Odle n , T. Pfeiler n, E. Loboa n, C. Stahl n

MeSH headings : 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics; 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / metabolism; Animals; Animals, Newborn; Bone Density; Bone Development; Bone and Bones / chemistry; Calcitriol / blood; Calcium / blood; Calcium / deficiency; Calcium, Dietary / administration & dosage; Cell Differentiation; Cell Proliferation; Cells, Cultured; Female; Gene Expression Regulation; Male; Mechanical Phenomena; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Nutritional Status; Parathyroid Hormone / blood; RNA, Messenger / metabolism; Receptors, Calcium-Sensing / genetics; Receptors, Calcium-Sensing / metabolism; Sus scrofa
TL;DR: The results indicate that neonatal Ca nutrition is crucial for bone integrity and suggest that early-life Ca restriction may have long-term effects on bone integrity via programming of MSC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Dietary Phosphate Restriction Decreases Stem Cell Proliferation and Subsequent Growth Potential in Neonatal Pigs

JOURNAL OF NUTRITION, 140(3), 477–482.

By: L. Alexander n, A. Mahajan n, J. Odle n , K. Flann*, R. Rhoads * & C. Stahl n

Contributors: L. Alexander n, A. Mahajan n, J. Odle n , K. Flann*, R. Rhoads * & C. Stahl n

MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Bone Density / drug effects; Bone Marrow / drug effects; Bone Marrow / metabolism; Cell Proliferation / drug effects; Diet / veterinary; Female; Kidney / drug effects; Kidney / metabolism; Male; Mesenchymal Stem Cells / drug effects; Phosphorus / deficiency; Phosphorus, Dietary / pharmacology; Swine / growth & development; Weight Gain / drug effects
TL;DR: Data indicate that in addition to reductions in muscle and bone growth, dietary PO(4) affects proliferation of tissue-specific stem cells in vivo, which may have profound implications for life-long growth potential. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

A calcitonin receptor (CALCR) single nucleotide polymorphism is associated with growth performance and bone integrity in response to dietary phosphorus deficiency

JOURNAL OF ANIMAL SCIENCE, 88(3), 1009–1016.

By: L. Alexander n, A. Qu*, S. Cutler*, A. Mahajan n, M. Rothschild*, W. Cai *, J. Dekkers *, C. Stahl n

author keywords: bone; genotype; phosphorus; pig
MeSH headings : Alkaline Phosphatase / blood; Animals; Body Weight / genetics; Body Weight / physiology; Bone and Bones / physiology; Female; Genotype; Phosphorus / blood; Phosphorus / deficiency; Polymorphism, Single Nucleotide / genetics; Polymorphism, Single Nucleotide / physiology; Receptors, Calcitonin / genetics; Receptors, Calcitonin / physiology; Swine / genetics; Swine / growth & development; Swine / physiology
TL;DR: It is demonstrated that genetic background impacts P utilization in young pigs and genetic polymorphisms in several target genes related to mineral utilization are identified, supportive of the association of this CALCR SNP with bone integrity and its response to dietary P restriction. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Dihydroxy-cholecalciferol stimulates adipocytic differentiation of porcine mesenchymal stem cells

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 20(7), 512–520.

By: A. Mahajan n & C. Stahl n

author keywords: Mesenchymal stem cells; Dihydroxy-cholecalciferol; Pig; Adipogenesis; Osteogenesis
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adipogenesis / drug effects; Animals; Calcitriol / blood; Calcitriol / pharmacology; Cell Differentiation / drug effects; Cell Proliferation / drug effects; Cells, Cultured; Gene Expression / drug effects; Gene Expression Regulation / drug effects; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / physiology; PPAR gamma / metabolism; RNA, Messenger / metabolism; Swine / blood; Swine / physiology
TL;DR: The data suggest that 1,25(OH)(2)D(3) stimulates the differentiation of porcine MSC towards an adipocytic phenotype, and the concentrations of mRNAs encoding peroxisome proliferator-activated receptor gamma, lipoprotein lipase, and adipocyte-binding protein 2 were increased and decreased, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Response to dietary phosphorus deficiency is affected by genetic background in growing pigs

JOURNAL OF ANIMAL SCIENCE, 86(10), 2585–2595.

By: L. Alexander n, A. Qu*, S. Cutler*, A. Mahajan n, S. Lonergan *, M. Rothschild*, T. Weber, B. Kerr, C. Stahl n

author keywords: bone; meat quality; phosphorus; pig
MeSH headings : Animal Feed / analysis; Animal Nutritional Physiological Phenomena; Animals; Body Composition / drug effects; Body Composition / genetics; Bone Density; Diet / veterinary; Female; Gene Expression Regulation; Kidney / metabolism; Meat / standards; Phosphorus / deficiency; Phosphorus, Dietary / pharmacology; Swine / genetics; Swine / growth & development
TL;DR: Different mechanisms of P utilization between these genetic lines are indicated, which may lead to strategies to increase efficiency of growth in a more environmentally friendly manner. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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