Works (2)

Updated: July 5th, 2023 15:46

2013 journal article

A lifelong model for the female reproductive cycle with an antimullerian hormone treatment to delay menopause


By: A. Margolskee n & J. Selgrade n

author keywords: Menstrual cycle; Primordial follicle; Parameter identification
MeSH headings : Adult; Anti-Mullerian Hormone / administration & dosage; Computer Simulation; Female; Humans; Longevity / physiology; Menopause / drug effects; Menstrual Cycle / drug effects; Menstrual Cycle / physiology; Middle Aged; Models, Biological; Primary Ovarian Insufficiency / prevention & control; Reproduction / physiology; Time Factors; Young Adult
TL;DR: A system of 16 non-linear, delay differential equations with 66 parameters is developed to model hormonal regulation of the menstrual cycle of a woman from age 20 to 51 and shows that the transfer of non-growing primordial follicles to the active state can be slowed enough to provide more follicles for development later in life and to cause a delay in the onset of menopause. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Dynamics and bifurcation of a model for hormonal control of the menstrual cycle with inhibin delay


By: A. Margolskee n & J. Selgrade n

author keywords: Estradiol; Follicle; Hill function; Degenerate Hopf bifurcation
MeSH headings : Computer Simulation; Estradiol / physiology; Female; Follicle Stimulating Hormone / antagonists & inhibitors; Follicle Stimulating Hormone / physiology; Humans; Inhibins / physiology; Menstrual Cycle / physiology; Models, Biological; Ovarian Follicle / physiology; Ovulation / physiology
TL;DR: A system of 13 ordinary differential equations with 42 parameters is presented to model hormonal regulation of the menstrual cycle and requires a 36 h time delay for the effect of inhibin on the synthesis of follicle stimulating hormone. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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