April Melanie Lewis

Works (5)

Updated: April 23rd, 2025 19:48

2023 article

Extremely thermoacidophilic archaea for metal bioleaching: What do their genomes tell Us?

Manesh, M. J. H., Willard, D. J., Lewis, A. M., & Kelly, R. M. (2023, November 9). Bioresource Technology, Vol. 391.

By: M. Manesh  n, D. Willard n, A. Lewis n & R. Kelly n 

author keywords: Archaea; Sulfolobales; Metal biooxidation; Sulfur biooxidation; Chalcopyrite; High temperatures
MeSH headings : Archaea / genetics; Archaea / metabolism; Oxidation-Reduction; Metals / metabolism; Copper / metabolism; Minerals
topics (OpenAlex): Metal Extraction and Bioleaching; Corrosion Behavior and Inhibition; Extraction and Separation Processes
TL;DR: The evolving landscape for bioleaching technologies at high temperatures merits a closer look through a genomic lens at what is currently possible and what lies ahead in terms of new developments and emerging opportunities. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 article

Interplay between transcriptional regulators and VapBC toxin–antitoxin loci during thermal stress response in extremely thermoacidophilic archaea

Cooper, C. R., Lewis, A. M., Notey, J. S., Mukherjee, A., Willard, D. J., Blum, P. H., & Kelly, R. M. (2023, February 8). Environmental Microbiology, Vol. 2.

By: C. Cooper  n, A. Lewis n, J. Notey n, A. Mukherjee n, D. Willard n, P. Blum *, R. Kelly n 

MeSH headings : Antitoxins / genetics; Toxins, Biological / genetics; Toxins, Biological / metabolism; Heat-Shock Response / genetics; Sulfolobus solfataricus / genetics; Sulfolobus solfataricus / metabolism; Escherichia coli / genetics
topics (OpenAlex): Enzyme Structure and Function; Genomics and Phylogenetic Studies; Protein Structure and Dynamics
TL;DR: The interplay between VapBC TA loci and heat shock regulators in Sa. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2023 article

Stay or Go: Sulfolobales Biofilm Dispersal Is Dependent on a Bifunctional VapB Antitoxin

Lewis, A. M., Willard, D. J., Manesh, M. J. H., Sivabalasarma, S., Albers, S.-V., & Kelly, R. M. (2023, April 10). MBio, Vol. 4.

By: A. Lewis n, D. Willard n, M. Manesh  n, S. Sivabalasarma *, S. Albers * & R. Kelly n 

author keywords: toxin-antitoxin loci; biofilms; Sulfolobales; thermoacidophiles; Sulfolobus acidocaldarius
MeSH headings : Antitoxins / metabolism; Bacterial Proteins / metabolism; Bacterial Toxins / metabolism; Sulfolobales; Biofilms
topics (OpenAlex): Bacterial biofilms and quorum sensing; Vibrio bacteria research studies; Antibiotic Resistance in Bacteria
TL;DR: The findings here suggest that a stand-alone VapB-type antitoxin was the product of selective evolutionary pressure to influence biofilm formation in these archaea, a vital microbial community behavior. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 9, 2023

2020 journal article

The biology of thermoacidophilic archaea from the order Sulfolobales

FEMS Microbiology Reviews, 1.

By: A. Lewis n, A. Recalde *, C. Bräsen *, J. Counts n, P. Nussbaum*, J. Bost*, L. Schocke*, L. Shen * ...

author keywords: Archaea; Thermoacidophiles; Sulfolobales
MeSH headings : Archaea / genetics; Biology; Iron; Sulfolobales
topics (OpenAlex): Genomics and Phylogenetic Studies; Microbial Community Ecology and Physiology; Enzyme Production and Characterization
TL;DR: The nuances of the thermoacidophilic lifestyle of the Sulfolobales are discussed, including their evolutionary placement, cell biology, survival strategies, genetic tools, metabolic processes, and physiological attributes together with how these characteristics make thermo Acidophiles ideal platforms for specialized industrial processes. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: July 14, 2021

2019 journal article

Extreme thermophiles as emerging metabolic engineering platforms

Current Opinion in Biotechnology, 59, 55–64.

By: J. Crosby n, T. Laemthong n, A. Lewis n, C. Straub n, M. Adams * & R. Kelly n 

MeSH headings : Archaea; Biotechnology; Genetic Engineering; Metabolic Engineering; Waste Products
topics (OpenAlex): Enzyme Catalysis and Immobilization; Microbial Metabolic Engineering and Bioproduction; Biofuel production and bioconversion
TL;DR: If non-model platforms are successfully deployed, new avenues for production of fuels and chemicals from renewable feedstocks or waste materials will emerge. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: November 25, 2019

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