@article{dannemiller_lynch_christiansen_harms_2024, title={An 18-μm microaggregate blood filter does not cause hemolysis during in vitro whole blood transfusions in sea turtles}, volume={85}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.23.12.0269}, abstractNote={Determine the hemolytic effect of an 18-µm microaggregate blood filter during in vitro sea turtle whole blood transfusions as well as describe the average diameter of leatherback (Dermochelys coriacea) and Kemp's ridley sea turtle (Lepidochelys kempii) RBCs.}, number={5}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Dannemiller, Nicholas G. and Lynch, Alex M. and Christiansen, Emily F. and Harms, Craig A.}, year={2024}, month={May} }
 @article{heniff_lynch_ruterbories_minter_georoff_balko_2024, title={INVESTIGATION OF A POINT-OF-CARE VISCOELASTIC COAGULATION MONITOR AND ITS COMPARISON TO THROMBOELASTOGRAPHY IN CLINICALLY HEALTHY AFRICAN ELEPHANTS (<i>LOXODONTA AFRICANA</i>)}, volume={55}, ISSN={["1937-2825"]}, DOI={10.1638/2022-0158}, abstractNote={Elephant endotheliotropic herpesvirus (EEHV) can induce fatal hemorrhagic disease (HD) in African elephants (Loxodonta africana). Once clinical signs develop, progression is rapid, even with aggressive treatment. There is a critical need to develop point-of-care diagnostic tests to aid in identification of EEHV-HD prior to the onset of overt clinical signs. Study objectives were to investigate a novel, point-of-care viscoelastic coagulation monitor (VCM Vet), compare the results to thromboelastography (TEG), and report traditional hemostatic analytes in adult African elephants. Whole blood was collected from seven clinically healthy elephants (four females and three males, 18-47 yr) and analyzed in duplicate via VCM Vet and kaolin-activated TEG 1-3 and 30 min following collection, respectively. Separated plasma was frozen for ancillary coagulation testing. Both analyses generated quantifiable clotting reactions with variables (median [range]) describing clot formation rate (VCM Vet, clot time = 682 s [530-987 s], clot formation time = 244 s [186-744 s], Alpha = 40° [14-47°]; TEG, reaction time = 6.2 min [3.7-11.8 min], kinetic time = 1.3 min [0.9-2.6 min], Alpha = 70° [57-77°]), clot strength (VCM Vet, maximum clot formation = 34 units [20-45 units]; TEG, maximum amplitude = 75 mm [69-80 mm], shear elastic modulus strength = 14.7 Kdynes/s [11.3-19.5 Kdynes/s]), and clot lysis (VCM Vet, lysis index at 30 min = 100% [100-99%], lysis index at 45 min = 98% [95-100%]; TEG, lysis index at 30 min = 0% [0-0.4%], lysis index at 60 min = 1.4% [0-2.6%]) recorded. Additional testing (median [range]) included D-dimer concentration (33 ng/ml [28-94 ng/ml]), prothrombin time (12.4 s [12.2-13.2 s]), activated partial thromboplastin time (17.2 s [14.2-18.8 s]), and fibrinogen concentration (297 [282-383] mg/dL). Tracings generated by VCM Vet and TEG were clinically similar, and there was visual agreement and minimal difference between quantitative variables for duplicate tests. VCM Vet is a promising, user-friendly tool for use in identification and management of coagulopathies in African elephants.}, number={1}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Heniff, Ashlyn C. and Lynch, Alex M. and Ruterbories, Laura K. and Minter, Larry J. and Georoff, Timothy A. and Balko, Julie A.}, year={2024}, month={Mar}, pages={164–172} }
 @article{wimbish_lynch_knych_ueda_messenger_2024, title={Pharmacokinetics of a continuous intravenous infusion of hydromorphone in healthy dogs}, volume={11}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2024.1362730}, abstractNote={Introduction Dosing recommendations for hydromorphone intravenous constant rate infusion (IV CRI) are derived from simulations following IV bolus administration. While this extrapolated dose regimen has been described clinically, pharmacokinetics (PK) of hydromorphone infusions in dogs are not yet described. The study objective was to describe the PK of hydromorphone in healthy dogs receiving an IV bolus followed by an IV CRI for 48 h. Methods A prospective, experimental study was performed involving the administration of hydromorphone (0.1 mg/kg IV bolus then IV CRI 0.01 mg/kg/h over a 48 h period) to 6 healthy Beagle dogs. Blood samples were collected at 16 time points between 0 and 58 h relative to the initial bolus. Plasma hydromorphone concentrations were analyzed by high pressure liquid chromatography with tandem mass spectrometry detection. Pharmacokinetic parameter estimates were obtained with compartmental methods using commercially available software. Results A two-compartment model with first order elimination was used. At the end of the infusion, median (range) plasma hydromorphone concentrations were 6.8 (5.5–19.6) ng/mL. The median total body clearance was 30.4 (19.8–36.7) mL/min/kg; volume of distribution at steady state was 4.5 (3.2–7.8) L/kg; and terminal elimination half-life was 11.2 (7.6–24.3) h. Conclusion Hydromorphone (0.1 mg/kg IV bolus then IV CRI of 0.01 mg/kg/h) maintained steady-state plasma concentrations above the minimum human analgesic target in healthy Beagle dogs with minimal side effects. Further studies are needed to determine the effective plasma concentrations of hydromorphone in painful dogs.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Wimbish, Candace and Lynch, Alex M. and Knych, Heather K. and Ueda, Yu and Messenger, Kristen M.}, year={2024}, month={Apr} }
 @article{rank_lynch_green_reed-jones_harrell_ueda_2023, title={Case report: Laryngospasm following ethanol ablation of a parathyroid nodule in a dog with primary hyperparathyroidism}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1201663}, abstractNote={A 12-year-old female spayed dachshund was presented for emergency assessment of respiratory distress, characterized by inspiratory dyspnea with stridor. Percutaneous ultrasound-guided ethanol ablation of a functional parathyroid tumor was performed 72-h earlier for management of primary hyperparathyroidism. The dog was hypocalcemic (ionized calcium 0.7 mmol/L, reference interval: 0.9–1.3 mmol/L) at the time of presentation and had evidence of laryngospasm on a sedated oral exam. The dog was managed conservatively with supplemental oxygen, anxiolysis, and parenteral calcium administration. These interventions were associated with rapid and sustained improvement in clinical signs. The dog did not demonstrate any recurrence of signs afterwards. To the authors' knowledge, this is the first description of laryngospasm following ethanol ablation of a parathyroid nodule in a dog that developed hypocalcemia.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Rank, Kaitlyn and Lynch, Alex M. and Green, Randolph and Reed-Jones, Leslie and Harrell, Karyn and Ueda, Yu}, year={2023}, month={Jun} }
 @article{rank_lynch_ruterbories_li_ueda_2023, title={Evaluation of thrombin generation in dogs administered clopidogrel}, volume={10}, ISSN={2297-1769}, url={http://dx.doi.org/10.3389/fvets.2023.1194242}, DOI={10.3389/fvets.2023.1194242}, abstractNote={IntroductionThe antiplatelet effect of clopidogrel can vary between patients. A modified thromboelastography (TEG) protocol (TEG-Platelet Mapping assay® [TEG-PM]) can be used for clopidogrel monitoring but is not widely available. Thrombin generation (TG) assays could offer a novel alternative. The main objective of this pilot study was to assess TG assay variables (lag time, peak, endogenous thrombin potential [ETP]) in dogs before and after 7 days of clopidogrel administration and compare with TEG-PM variables (maximum amplitude [MA]-ADP and percentage (%) inhibition).}, journal={Frontiers in Veterinary Science}, publisher={Frontiers Media SA}, author={Rank, Kaitlyn and Lynch, Alex M. and Ruterbories, Laura K. and Li, Ronald H. L. and Ueda, Yu}, year={2023}, month={Aug} }
 @article{lynch_ruterbories_robertson_lunn_mowat_2023, title={Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome}, volume={4}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.16710}, DOI={10.1111/jvim.16710}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Lynch, Alex M. M. and Ruterbories, Laura K. K. and Robertson, James B. B. and Lunn, Katharine F. F. and Mowat, Freya M. M.}, year={2023}, month={Apr} }
 @article{amirsultan_lynch_meritet_nelson_2023, title={Persistent spontaneous pneumomediastinum in a dog with pulmonary fibrosis}, volume={8}, ISSN={["2052-6121"]}, DOI={10.1002/vrc2.708}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, author={Amirsultan, Sophia and Lynch, Alex and Meritet, Danielle and Nelson, Nathan}, year={2023}, month={Aug} }
 @article{delaforcade_bacek_blais_boyd_brainard_chan_cortellini_goggs_hoareau_koenigshof_et al._2022, title={2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 1‐ Defining populations at risk}, volume={32}, ISSN={1479-3261 1476-4431}, url={http://dx.doi.org/10.1111/vec.13204}, DOI={10.1111/vec.13204}, abstractNote={Abstract}, number={3}, journal={Journal of Veterinary Emergency and Critical Care}, publisher={Wiley}, author={deLaforcade, Armelle and Bacek, Lenore and Blais, Marie‐Claude and Boyd, Corrin and Brainard, Benjamin M and Chan, Daniel L. and Cortellini, Stefano and Goggs, Robert and Hoareau, Guillaume L and Koenigshof, Amy and et al.}, year={2022}, month={May}, pages={289–314} }
 @article{sharp_blais_boyd_brainard_chan_laforcade_goggs_guillaumin_lynch_mays_et al._2022, title={2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care (CURATIVE) Domain 6: Defining rational use of thrombolytics}, volume={32}, ISSN={["1476-4431"]}, DOI={10.1111/vec.13227}, abstractNote={Abstract}, number={4}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Sharp, Claire R. and Blais, Marie-Claude and Boyd, Corrin J. and Brainard, Benjamin M. and Chan, Daniel L. and Laforcade, Armelle and Goggs, Robert and Guillaumin, Julien and Lynch, Alex and Mays, Erin and et al.}, year={2022}, month={Jul}, pages={446–470} }
 @article{tracy_goggs_brooks_lynch_2022, title={Clinical features and posttreatment monitoring of dogs administered rivaroxaban (2018-2020): 19 cases}, volume={4}, ISSN={["1476-4431"]}, DOI={10.1111/vec.13199}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Tracy, Alyxandra L. and Goggs, Robert and Brooks, Marjory B. and Lynch, Alex M.}, year={2022}, month={Apr} }
 @article{chalifoux_butty_mauro_moyle_ehrhardt_robertson_labato_culler_londono_vigani_et al._2022, title={Outcomes of 434 dogs with non-steroidal anti-inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange}, volume={12}, ISSN={["1939-1676"]}, url={http://dx.doi.org/10.1111/jvim.16603}, DOI={10.1111/jvim.16603}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, publisher={Wiley}, author={Chalifoux, Nolan V. and Butty, Emmanuelle M. and Mauro, Katie D. and Moyle, Rachel B. and Ehrhardt, Caryn M. and Robertson, James B. and Labato, Mary A. and Culler, Christine A. and Londono, Leonel A. and Vigani, Alessio and et al.}, year={2022}, month={Dec} }
 @article{butty_suter_chalifoux_lynch_mauro_moyle_ehrhardt_robertson_culler_londono_et al._2022, title={Outcomes of nonsteroidal anti-inflammatory drug toxicosis treated with therapeutic plasma exchange in 62 dogs}, volume={8}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16507}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Butty, Emmanuelle M. and Suter, Steven E. and Chalifoux, Nolan V and Lynch, Alex M. and Mauro, Katie D. and Moyle, Rachel B. and Ehrhardt, Caryn M. and Robertson, James B. and Culler, Christine A. and Londono, Leonel A. and et al.}, year={2022}, month={Aug} }
 @article{wang_lynch_balko_duffy_robertson_posner_2022, title={Point-of-care viscoelastic coagulation assessment in healthy dogs during the perianesthetic period}, volume={18}, ISSN={["1746-6148"]}, DOI={10.1186/s12917-022-03442-x}, abstractNote={Abstract}, number={1}, journal={BMC VETERINARY RESEARCH}, author={Wang, Wen H. and Lynch, Alex M. and Balko, Julie A. and Duffy, Daniel J. and Robertson, James B. and Posner, Lysa P.}, year={2022}, month={Sep} }
 @article{perry_lynch_caudill_vigani_roberston_vaden_2021, title={Clinical features, outcome, and illness severity scoring in 32 dogs with urosepsis (2017-2018)}, volume={11}, ISSN={["1476-4431"]}, DOI={10.1111/vec.13158}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Perry, Kayla M. and Lynch, Alex M. and Caudill, Alexander and Vigani, Alessio and Roberston, James B. and Vaden, Shelly}, year={2021}, month={Nov} }
 @article{lynch_ruterbories_griffith_hanel_stablein_brooks_2021, title={Evaluation of point-of-care coagulation tests as alternatives to anti-Xa activity for monitoring the anticoagulant effects of rivaroxaban in healthy dogs}, volume={31}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13011}, DOI={10.1111/vec.13011}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Lynch, Alex M. and Ruterbories, Laura K. and Griffith, Emily H. and Hanel, Rita M. and Stablein, Alyssa P. and Brooks, Marjory B.}, year={2021}, month={Jan}, pages={18–24} }
 @article{kielb basile_lynch_ruterbories_castaneda_griffith_ueda_2021, title={Influence of long-stay jugular catheters on hemostatic variables in healthy dogs}, volume={7}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13085}, DOI={10.1111/vec.13085}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Kielb Basile, Jessica L. and Lynch, Alex M. and Ruterbories, Laura and Castaneda, Kady and Griffith, Emily and Ueda, Yu}, year={2021}, month={Jul} }
 @article{wolf_law_lynch_2021, title={Non-cardiogenic pulmonary oedema and multisystemic haemorrhage secondary to an accidental intravenous injection of melarsomine in a dog}, volume={9}, ISSN={["2052-6121"]}, DOI={10.1002/vrc2.196}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, author={Wolf, Johanna and Law, Jerry M. and Lynch, Alex}, year={2021}, month={Sep} }
 @article{harms_ruterbories_stacy_christiansen_papich_lynch_barratclough_serrano_2021, title={SAFETY OF MULTIPLE-DOSE INTRAMUSCULAR KETOPROFEN TREATMENT IN LOGGERHEAD TURTLES (CARETTA CARETTA)}, volume={52}, ISSN={["1937-2825"]}, DOI={10.1638/2020-0159}, abstractNote={Abstract: Sea turtles are frequently presented for rehabilitation with injuries for which analgesic treatment is warranted. Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely used in clinical veterinary medicine for musculoskeletal pain relief. Pharmacokinetics of 2 mg/kg IM have been studied in loggerhead sea turtles (Caretta caretta) as a single and a repeated dose q24hr for 3 days. Safety of longer term administration has not been performed, however, and NSAID use carries a risk of potential complications, including gastrointestinal ulceration, kidney damage, and bleeding. The objective of the current study was to determine the effects of a 5-day course of ketoprofen on thromboelastography (TEG) and hematological (including thrombocytes) and plasma biochemical analytes in loggerheads. A secondary objective was to determine 24-hr trough concentrations of ketoprofen after 5 days of treatment. Eight loggerheads were treated with ketoprofen 2 mg/kg IM q24hr for 5 days, and TEG, hematology, and plasma biochemistry panels were performed before and at the conclusion of treatment. Eight controls were treated with an equivalent volume of saline intramuscularly. Virtually no changes were detected before and after treatment or between treatment and control groups in any of the 24 endpoints evaluated, and marginal differences were not considered clinically relevant. Plasma ketoprofen concentrations after 5 days of treatment indicated no accumulation over that duration. Ketoprofen at 2 mg/kg IM q24hr for up to 5 days in loggerheads appears safe with respect to blood clotting and blood data, although other potential effects were not evaluated.}, number={1}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Harms, Craig A. and Ruterbories, Laura K. and Stacy, Nicole I and Christiansen, Emily F. and Papich, Mark G. and Lynch, Alex M. and Barratclough, Ashley and Serrano, Maria E.}, year={2021}, month={Mar}, pages={126–132} }
 @article{lynch_ruterbories_griffith_hanel_stablein_brooks_2021, title={The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs}, volume={31}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.13019}, DOI={10.1111/vec.13019}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Lynch, Alex M. and Ruterbories, Laura K. and Griffith, Emily and Hanel, Rita M. and Stablein, Alyssa P. and Brooks, Marjory B.}, year={2021}, month={Jan}, pages={59–65} }
 @article{johnson_wigglesworth_moyle_lynch_2021, title={Use of a polyethylene glycol solution for the management of sand impaction in three dogs}, volume={6}, ISSN={["2052-6121"]}, DOI={10.1002/vrc2.124}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, author={Johnson, Randi and Wigglesworth, Samantha and Moyle, Rachel and Lynch, Alex}, year={2021}, month={Jun} }
 @article{tracy_lynch_messenger_vaden_vigani_2021, title={Use of extracorporeal therapy in a dog with heatstroke}, volume={12}, ISSN={["1476-4431"]}, DOI={10.1111/vec.13169}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Tracy, Alyx and Lynch, Alex and Messenger, Kristen and Vaden, Shelly and Vigani, Alessio}, year={2021}, month={Dec} }
 @article{tolbert_spencer_lynch_papich_lidbury_2020, title={Capsule endoscopy detects insufficient treatment of gastric bleeding in a dog with chronic hepatitis}, volume={8}, ISSN={["2052-6121"]}, DOI={10.1136/vetreccr-2020-001238}, abstractNote={A five‐year‐old dog was presented for a chronic non‐regenerative anaemia, copper‐associated chronic hepatitis and suspected portal hypertension. The anaemia was suspected to be from gastrointestinal (GI) bleeding and persisted despite chronic omeprazole treatment (1.1 mg/kg orally every 12 hours). Capsule endoscopy confirmed severe gastric bleeding. A pH capsule was orally administered to evaluate the efficacy of gastric acid suppressant treatment. The mean gastric pH of the dog over the three‐hour monitoring period was 4.7, and the percentage time that the intragastric pH were ≥3 and 4 were 100 per cent and 99 per cent, respectively. Substantial upper GI bleeding persisted despite excellent gastric acid suppression, bringing into question the value of routinely recommending such therapy in dogs with hepatic failure without additional monitoring for adequacy of treatment.}, number={4}, journal={VETERINARY RECORD CASE REPORTS}, author={Tolbert, M. Katherine and Spencer, Ashley and Lynch, Alex M. and Papich, Mark G. and Lidbury, Jonathan A.}, year={2020}, month={Oct} }
 @article{pavlides_lynch_snowden_leissinger_2020, title={Evaluation of an emergency medicine-focused clinical pathology training course for non-clinical pathology house officers}, volume={30}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12938}, DOI={10.1111/vec.12938}, abstractNote={Abstract}, number={2}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Pavlides, Stavros and Lynch, Alex and Snowden, Khalid and Leissinger, Mary}, year={2020}, month={Mar}, pages={165–169} }
 @article{granick_lynch_cohen_2020, title={Extrahepatic biliary tract obstruction secondary to a diaphragmatic rent in a dog}, volume={8}, ISSN={["2052-6121"]}, DOI={10.1136/vetreccr-2019-001060}, abstractNote={A 13‐month‐old intact female Akita was referred to a specialty hospital with suspected pancreatitis. Radiographs at the time of presentation showed atypical positioning of the pylorus and proximal descending duodenum, spleen and right kidney. Abdominal ultrasound showed features suggestive of a diaphragmatic rent with pyloric entrapment, resulting in pyloric and extrahepatic biliary obstruction. Subsequent exploratory coeliotomy identified a right dorsolateral diaphragmatic rent with pyloric, proximal duodenal, right pancreatic and associated omental entrapment. A diaphragmatic herniorraphy was performed resulting in complete clinical resolution.}, number={2}, journal={VETERINARY RECORD CASE REPORTS}, author={Granick, Martin and Lynch, Alex Michael and Cohen, Eli}, year={2020}, month={Jun} }
 @article{rossi_stachel_lynch_olby_2020, title={Intervertebral disc disease and aortic thromboembolism are the most common causes of acute paralysis in dogs and cats presenting to an emergency clinic}, volume={187}, ISSN={["2042-7670"]}, url={https://doi.org/10.1136/vr.105844}, DOI={10.1136/vr.105844}, abstractNote={BackgroundAcute paralysis is a common presentation in small animal emergency clinics, but the aetiological prevalence has not been reported. Knowledge of diagnosis frequency aids prioritisation of differential diagnoses, facilitates resource planning and clinical trial design.}, number={10}, journal={VETERINARY RECORD}, author={Rossi, Graham and Stachel, Alexandra and Lynch, Alex M. and Olby, Natasha J.}, year={2020}, month={Nov} }
 @article{ruehl_lynch_therese e. o'toole_morris_rush_couto_hmelo_sonnenshein_butler_guillaumin_2020, title={Outcome and treatments of dogs with aortic thrombosis: 100cases(1997-2014)}, volume={34}, ISSN={["1939-1676"]}, url={https://europepmc.org/articles/PMC7517508}, DOI={10.1111/jvim.15874}, abstractNote={Abstract}, number={5}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Ruehl, Mackenzie and Lynch, Alex M. and Therese E. O'Toole and Morris, Bari and Rush, John and Couto, C. Guillermo and Hmelo, Samantha and Sonnenshein, Stacey and Butler, Amy and Guillaumin, Julien}, year={2020}, month={Sep}, pages={1759–1767} }
 @article{lynch_ruterbories_jack_motsinger-reif_hanel_2020, title={The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood}, volume={30}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12979}, DOI={10.1111/vec.12979}, abstractNote={Abstract}, number={4}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Lynch, Alex M. and Ruterbories, Laura and Jack, John and Motsinger-Reif, Alison A. and Hanel, Rita}, year={2020}, month={Jul}, pages={418–425} }
 @article{didomenico_stowe_lynch_2020, title={What is your diagnosis? Abdominal fluid from a dog}, volume={49}, ISSN={0275-6382 1939-165X}, url={http://dx.doi.org/10.1111/vcp.12815}, DOI={10.1111/vcp.12815}, abstractNote={Veterinary Clinical PathologyVolume 49, Issue 1 p. 164-166 WHAT IS YOUR DIAGNOSIS? What is your diagnosis? Abdominal fluid from a dog Amy E. DiDomenico, Amy E. DiDomenico orcid.org/0000-0001-6818-5599 Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this authorDevorah M. Stowe, Corresponding Author Devorah M. Stowe damarks@ncsu.edu Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA Correspondence Devorah M. Stowe, Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. Email: damarks@ncsu.eduSearch for more papers by this authorAlex M. Lynch, Alex M. Lynch Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this author Amy E. DiDomenico, Amy E. DiDomenico orcid.org/0000-0001-6818-5599 Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this authorDevorah M. Stowe, Corresponding Author Devorah M. Stowe damarks@ncsu.edu Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA Correspondence Devorah M. Stowe, Department of Public Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA. Email: damarks@ncsu.eduSearch for more papers by this authorAlex M. Lynch, Alex M. Lynch Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USASearch for more papers by this author First published: 12 January 2020 https://doi.org/10.1111/vcp.12815Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume49, Issue1March 2020Pages 164-166 This article also appears in:What is your diagnosis? Virtual Issue RelatedInformation}, number={1}, journal={Veterinary Clinical Pathology}, publisher={Wiley}, author={DiDomenico, Amy E. and Stowe, Devorah M. and Lynch, Alex M.}, year={2020}, month={Mar}, pages={164–166} }
 @article{davy_campos_lynch_2019, title={Acute chlorfenapyr toxicity in 3 dogs from a single household}, volume={29}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12894}, DOI={10.1111/vec.12894}, abstractNote={Abstract}, number={6}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Davy, Rachel B. and Campos, Samantha and Lynch, Alex M.}, year={2019}, month={Nov}, pages={686–689} }
 @article{delaforcade_bacek_blais_goggs_lynch_rozanski_2019, title={Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 1-Defining populations at risk}, volume={29}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12797}, DOI={10.1111/vec.12797}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={deLaforcade, Armelle and Bacek, Lenore and Blais, Marie-Claude and Goggs, Robert and Lynch, Alex and Rozanski, Elizabeth}, year={2019}, pages={37–48} }
 @article{blais_bianco_goggs_lynch_palmer_ralph_sharp_2019, title={Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 3-Defining antithrombotic protocols}, volume={29}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12795}, DOI={10.1111/vec.12795}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Blais, Marie-Claude and Bianco, Domenico and Goggs, Robert and Lynch, Alex M. and Palmer, Lee and Ralph, Alan and Sharp, Claire R.}, year={2019}, pages={60–74} }
 @article{sharp_delaforcade_koenigshof_lynch_thomason_2019, title={Consensus on the Rational Use of Antithrombotics in Veterinary Critical Care (CURATIVE): Domain 4-Refining and monitoring antithrombotic therapies}, volume={29}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12794}, DOI={10.1111/vec.12794}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Sharp, Claire R. and deLaforcade, Armelle M. and Koenigshof, Amy M. and Lynch, Alex M. and Thomason, John M.}, year={2019}, pages={75–87} }
 @article{campos_allen-durrance_schaer_lynch_2019, title={Retrospective evaluation of Micrurus fulvius (Eastern coral snake) envenomation and the use of mechanical ventilation in dogs and a cat (2011-2016): 8 cases}, volume={29}, ISSN={["1476-4431"]}, url={https://doi.org/10.1111/vec.12892}, DOI={10.1111/vec.12892}, abstractNote={Abstract}, number={6}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Campos, Samantha and Allen-Durrance, Ashley E. and Schaer, Michael and Lynch, Alex}, year={2019}, month={Nov}, pages={662–667} }
 @article{tang_su_huang_dinh_wang_vandergriff_hensley_cores_allen_li_et al._2018, title={Targeted repair of heart injury by stem cells fused with platelet nanovesicles}, volume={2}, ISSN={2157-846X}, url={http://dx.doi.org/10.1038/s41551-017-0182-x}, DOI={10.1038/s41551-017-0182-x}, abstractNote={Stem cell transplantation, as used clinically, suffers from low retention and engraftment of the transplanted cells. Inspired by the ability of platelets to recruit stem cells to sites of injury on blood vessels, we hypothesized that platelets might enhance the vascular delivery of cardiac stem cells (CSCs) to sites of myocardial infarction injury. Here, we show that CSCs with platelet nanovesicles fused onto their surface membranes express platelet surface markers that are associated with platelet adhesion to injury sites. We also find that the modified CSCs selectively bind collagen-coated surfaces and endothelium-denuded rat aortas, and that in rat and porcine models of acute myocardial infarction the modified CSCs increase retention in the heart and reduce infarct size. Platelet-nanovesicle-fused CSCs thus possess the natural targeting and repairing ability of their parental cell types. This stem cell manipulation approach is fast, straightforward and safe, does not require genetic alteration of the cells, and should be generalizable to multiple cell types. The attachment of platelet nanovesicles to the surface of cardiac stem cells increases the retention of the cells delivered to the heart and reduces infarct size in rat and pig models of acute myocardial infarction.}, number={1}, journal={Nature Biomedical Engineering}, publisher={Springer Science and Business Media LLC}, author={Tang, Junnan and Su, Teng and Huang, Ke and Dinh, Phuong-Uyen and Wang, Zegen and Vandergriff, Adam and Hensley, Michael T. and Cores, Jhon and Allen, Tyler and Li, Taosheng and et al.}, year={2018}, month={Jan}, pages={17–26} }
 @article{rozanski_lynch_2017, title={Fluid Therapy in Lung Disease}, volume={47}, ISSN={0195-5616}, url={http://dx.doi.org/10.1016/J.CVSM.2016.10.013}, DOI={10.1016/J.CVSM.2016.10.013}, abstractNote={Fluid therapy is the cornerstone of supportive care in veterinary medicine. In dogs and cats with preexisting confirmed or suspected pulmonary disease, concerns may exist that the fluid therapy may impair gas exchange, either through increases in hydrostatic pressures or extravasation. Colloidal therapy is more likely to magnify lung injury compared with isotonic crystalloids. Radiographic evidence of fluid overload is a late-stage finding, whereas point-of-care ultrasound may provide earlier information that can also be assessed periodically at the patient side. Cases should be evaluated individually, but generally a conservative fluid therapy plan is preferred with close monitoring of its tolerance.}, number={2}, journal={Veterinary Clinics of North America: Small Animal Practice}, publisher={Elsevier BV}, author={Rozanski, Elizabeth and Lynch, Alex}, year={2017}, month={Mar}, pages={461–470} }
 @article{assessment of hemostatic changes in a model of acute hemorrhage in dogs._2016, url={https://doi.org/10.1111/vec.12457}, DOI={10.1111/vec.12457}, abstractNote={Abstract}, journal={Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)}, year={2016}, month={Feb} }
 @article{acute tracheal compression in a large breed dog due to a dorsal tracheal membrane abscess._2015, url={https://doi.org/10.1111/vec.12379}, DOI={10.1111/vec.12379}, abstractNote={Abstract}, journal={Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)}, year={2015}, month={Oct} }
 @article{hospital-acquired anemia in critically ill dogs and cats: a multi-institutional study._2015, url={https://europepmc.org/articles/PMC4913629}, DOI={10.1111/jvim.13650}, abstractNote={BackgroundHospital‐acquired anemia is commonly described in people but limited information currently is available regarding its prevalence in animals.}, journal={Journal of veterinary internal medicine}, year={2015}, month={Nov} }
 @article{massive haemorrhage associated with inadvertent incision of a suspected carotid artery pseudoaneurysm in a cat._2015, url={https://doi.org/10.1111/jsap.12372}, DOI={10.1111/jsap.12372}, abstractNote={A 12‐year‐old, castrated male, domestic long‐haired cat experienced massive haemorrhage associated with an incision of a swelling on the neck 2 weeks after right‐sided ventral bulla osteotomy. Emergent control of haemorrhage was gained through unilateral carotid artery ligation. Cardiopulmonary resuscitation was provided in conjunction with massive blood transfusion. The cat made an unremarkable recovery. Carotid artery pseudoaneurysm due to surgical disruption of the carotid artery during ventral bulla osteotomy, specifically through the use of self‐retaining retractors, was suspected. This case highlights the development of pseudoaneurysm as a potential complication of head and neck surgery, and additionally describes a case of massive transfusion in a cat.}, journal={The Journal of small animal practice}, year={2015}, month={May} }
 @article{transfusion practices for treatment of dogs hospitalized following trauma: 125 cases (2008-2013)._2015, url={https://doi.org/10.2460/javma.247.6.643}, DOI={10.2460/javma.247.6.643}, abstractNote={Abstract}, journal={Journal of the American Veterinary Medical Association}, year={2015}, month={Sep} }
 @article{transfusion practices for treatment of dogs undergoing splenectomy for splenic masses: 542 cases (2001-2012)._2015, url={https://doi.org/10.2460/javma.247.6.636}, DOI={10.2460/javma.247.6.636}, abstractNote={Abstract}, journal={Journal of the American Veterinary Medical Association}, year={2015}, month={Sep} }
 @article{clinical experience of anti-xa monitoring in critically ill dogs receiving dalteparin._2014, url={https://doi.org/10.1111/vec.12206}, DOI={10.1111/vec.12206}, abstractNote={Abstract}, journal={Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)}, year={2014}, month={Jul} }
 @article{vanherberghen_bureau_peters_day_lynch_fievez_billen_clercx_peeters_2013, title={Cytokine and transcription factor expression by Aspergillus fumigatus-stimulated peripheral blood mononuclear cells in dogs with sino-nasal aspergillosis}, volume={154}, ISSN={0165-2427}, url={http://dx.doi.org/10.1016/J.VETIMM.2013.05.009}, DOI={10.1016/J.VETIMM.2013.05.009}, abstractNote={The causal agent of sino-nasal aspergillosis is usually Aspergillus fumigatus, which is a saprophytic and ubiquitous fungus that causes a severe rhinosinusitis in apparent healthy dogs. Affected dogs do not have systemic immuno-suppression. It has been shown previously that dogs affected by this disease have local over-expression of interleukin (IL)-10 and Th1 cytokines in nasal mucosal tissue. The aim of the present study was to assess the response of peripheral blood mononuclear cells (PBMC) from affected and unaffected dogs to antigen-specific stimulation with heat-inactivated Aspergillus spp. conidia, by quantifying gene expression for specific Th1, Th2, Th17 and Treg cytokines and their related transcription factors. Quantification of IL-4 and IFN-γ protein in culture supernatant was performed by enzyme-linked immunosorbent assay (ELISA). PBMC from dogs with SNA produced adequate mRNA encoding IFN-γ and IFN-γ protein. The expression of IL-17A mRNA was significantly greater in PBMC of affected compared with unaffected dogs. The amount of IL-10 mRNA in PBMC from affected dogs decreased after antigen-specific challenge. These results suggest that the incapacity of affected dogs to clear these fungal infections is not related to a defect in Th1 immunity or to an overwhelming regulatory reaction, but rather to an uncontrolled pro-inflammatory reaction driven by Th17 cells.}, number={3-4}, journal={Veterinary Immunology and Immunopathology}, publisher={Elsevier BV}, author={Vanherberghen, M. and Bureau, F. and Peters, I.R. and Day, M.J. and Lynch, A. and Fievez, L. and Billen, F. and Clercx, C. and Peeters, D.}, year={2013}, month={Aug}, pages={111–120} }
 @article{postoperative haemorrhage associated with active suction drains in two dogs._2011, url={https://doi.org/10.1111/j.1748-5827.2011.01029.x}, DOI={10.1111/j.1748-5827.2011.01029.x}, abstractNote={ This article describes two dogs in which an active suction drain was placed to manage dead space at the surgical site and acute haemorrhage and hypovolaemia occurred postoperatively. In both instances, fluid resuscitation and temporary discontinuation of drainage resulted in resolution of clinical signs. Although the underlying cause of haemorrhage was not definitively identified, the use of low‐pressure drainage systems and avoidance of interference with local blood vessels should be considered. This is a previously undocumented complication of active suction drain use in veterinary patients. }, journal={The Journal of small animal practice}, year={2011}, month={Feb} }