Works (42)

Updated: March 25th, 2025 12:55

2025 journal article

An Exploratory Study on the Relationship Between Idiopathic Epilepsy and Sleep in Dogs

Journal of Veterinary Internal Medicine.

By: A. Mondino, J. Nettifee & K. Muñana

topics (OpenAlex): Neuroscience of respiration and sleep; Sleep and Wakefulness Research; Epilepsy research and treatment
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: ORCID
Added: March 15, 2025

2025 journal article

Familial Narcolepsy in Dogo Argentino Dogs Is Caused by a Tandem Duplication Mutation in HCRTR2

Familial Narcolepsy in Dogo Argentino Dogs Is Caused by a Tandem Duplication Mutation in HCRTR2. Journal of Veterinary Internal Medicine.

By: A. Mondino n, M. Vandewege n, R. Artigas, L. Delucchi, K. Hermida, C. Yanez, J. Cullen*, S. Friedenberg* ...

author keywords: cataplexy; genetic disease; hypocretins; sleep
topics (OpenAlex): Sleep and Wakefulness Research; Biochemical Analysis and Sensing Techniques; Regulation of Appetite and Obesity
Sources: ORCID, Web Of Science
Added: March 17, 2025

2024 journal article

A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD plus precursor combination

SCIENTIFIC REPORTS, 14(1).

author keywords: Aging; Senolytic; NAD plus; Canine cognitive dysfunction syndrome; Cognitive impairment; Longevity
topics (OpenAlex): Human-Animal Interaction Studies; Gut microbiota and health; Dementia and Cognitive Impairment Research
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024

2024 article

Characterising the power spectrum dynamics of the non-REM to REM sleep transition

Serantes, D., Cavelli, M., Gonzalez, J., Mondino, A., Benedetto, L., & Torterolo, P. (2024, November 9). JOURNAL OF SLEEP RESEARCH, Vol. 11.

author keywords: EEG; intermediate stage; REM sleep; sleep spindles; slow wave sleep
topics (OpenAlex): Sleep and Wakefulness Research; Neural dynamics and brain function; Neuroscience and Music Perception
Sources: Web Of Science, NC State University Libraries
Added: November 25, 2024

2024 journal article

Cross-sectional and longitudinal analysis of health-related quality of life (HRQoL) in senior and geriatric dogs

PLOS ONE, 19(9).

Ed(s): J. Suchodolski

topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Oncology Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 8, 2024

2024 journal article

Establishing a clinically applicable frailty phenotype screening tool for aging dogs

FRONTIERS IN VETERINARY SCIENCE, 11.

author keywords: frailty; canine frailty; frailty phenotype; geriatric; aging dogs
topics (OpenAlex): Frailty in Older Adults; Health Systems, Economic Evaluations, Quality of Life; Nutrition and Health in Aging
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2024

2024 journal article

Frequency of superoxide dismutase 1 c.118: G˃A mutation associated with canine degenerative myelopathy in German Shepherd dogs from Uruguay and Paraguay

Veterinary World.

By: R. Artigas, C. Menchaca, L. Castro*, A. Mondino n, Y. Perdomo, F. Bera, S. Stagno, M. Borca ...

topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Neurological diseases and metabolism; Veterinary Orthopedics and Neurology
Source: ORCID
Added: February 18, 2025

2024 article

Regulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons

Mondino, A., Jadidian, A., Toth, B., Hambrecht-Wiedbusch, V. S., Floran-Garduno, L., Li, D., … Vanini, G. (2024, October 4).

By: A. Mondino, A. Jadidian, B. Toth, V. Hambrecht-Wiedbusch, L. Floran-Garduno, D. Li, A. York, P. Torterolo ...

topics (OpenAlex): Sleep and Wakefulness Research; Circadian rhythm and melatonin; Sleep and related disorders
Source: ORCID
Added: February 18, 2025

2024 journal article

Urethane anaesthesia exhibits neurophysiological correlates of unconsciousness and is distinct from sleep

European Journal of Neuroscience.

topics (OpenAlex): Sleep and Wakefulness Research; Neural dynamics and brain function; Neuroscience and Neuropharmacology Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2023 journal article

A novel task of canine olfaction for use in adult and senior pet dogs

SCIENTIFIC REPORTS, 13(1).

MeSH headings : Dogs; Animals; Smell; Food; Aging; Neuropsychological Tests
topics (OpenAlex): Human-Animal Interaction Studies; Olfactory and Sensory Function Studies; Animal Behavior and Welfare Studies
TL;DR: A novel olfaction test using spontaneous search behavior in dogs to find a hidden food treat in a three-choice task with both light-phase and dark-phase conditions is described, making it feasible to compare between and within groups of pet dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 19, 2023

2023 article

Age-associated changes in electroretinography measures in companion dogs

Salzman, M. M., Merten, N., Panek, W. K., Fefer, G., Mondino, A., Westermeyer, H. D., … Mowat, F. M. (2023, June 11). DOCUMENTA OPHTHALMOLOGICA, Vol. 6.

author keywords: Translational model; Aging; Retina; ERG; Canine; Anxiolytic
topics (OpenAlex): Retinal Development and Disorders; Olfactory and Sensory Function Studies; Retinal Diseases and Treatments
TL;DR: Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs, as aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 19, 2023

2023 journal article

Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs

SCIENTIFIC REPORTS, 13(1).

topics (OpenAlex): Human-Animal Interaction Studies; Neuroscience of respiration and sleep; Infant Health and Development
TL;DR: A valid and reliable questionnaire tool is described, that can be used as a cost-effective way to monitor dog sleep in clinical settings. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
8. Decent Work and Economic Growth (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023

2023 journal article

Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs

FRONTIERS IN VETERINARY SCIENCE, 9.

author keywords: canine cognitive dysfunction syndrome; canine cognition; frustration; aging; dogs
topics (OpenAlex): Human-Animal Interaction Studies; Olfactory and Sensory Function Studies; Neuroendocrine regulation and behavior
TL;DR: The high correlation with several cognitive measures and the ease of administration of this test makes it a useful tool in evaluating canine cognitive dysfunction syndrome, however it is unclear if increased frustration or other cognitive processes are contributing to the observed changes. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2023 journal article

Sleep and cognition in aging dogs. A polysomnographic study

FRONTIERS IN VETERINARY SCIENCE, 10.

By: A. Mondino n, M. Catanzariti*, D. Mateos*, M. Khan n, C. Ludwig n, A. Kis*, M. Gruen n, N. Olby n

author keywords: NREM sleep; REM sleep; canine cognitive dysfunction syndrome; quantitative EEG; power spectrum; coherence; complexity
topics (OpenAlex): Sleep and Wakefulness Research; Neuroscience of respiration and sleep; Circadian rhythm and melatonin
TL;DR: Polysomnographic recordings in dogs can detect sleep-wakefulness cycle changes associated with dementia, and their potential clinical use to monitor the progression of canine cognitive dysfunction syndrome is evaluated. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023

2023 journal article

Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs

FRONTIERS IN VETERINARY SCIENCE, 10.

author keywords: canine cognitive dysfunction syndrome; canine gerontology; mobility; walking speed; memory; attention
topics (OpenAlex): Human-Animal Interaction Studies; Veterinary Orthopedics and Neurology; Veterinary Oncology Research
TL;DR: Dogs' food-motivated gait speed off leash is correlated with fractional lifespan and cognitive performance in dogs, particularly in the domains of attention and working memory and proves to be a more effective indicator of age-related deterioration and cognitive decline than gaitspeed on leash. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2022 article

Electroencephalographic Signatures of Canine Cognitive Dysfunction

Mondino, A., Gutiérrez, M., González, C., Mateos, D., Torterolo, P., Olby, N., & Delucchi, L. (2022, February 1). (Vol. 2). Vol. 2.

By: A. Mondino n, M. Gutiérrez, C. González, D. Mateos*, P. Torterolo*, N. Olby n, L. Delucchi

topics (OpenAlex): Human-Animal Interaction Studies; Neuroendocrine regulation and behavior; Neuroscience of respiration and sleep
TL;DR: Electroencephalogram findings specific to AD are described and demonstrated that, quantitative EEG can detect differences between normal dogs and dogs with CCD, and reinforce the CCD as a translational model of AD. (via Semantic Scholar)
Source: ORCID
Added: February 19, 2023

2022 journal article

Electroencephalographic signatures of dogs with presumptive diagnosis of canine cognitive dysfunction

RESEARCH IN VETERINARY SCIENCE, 150, 36–43.

By: A. Mondino n, M. Gutierrez, C. Gonzalez, D. Mateos*, P. Torterolo*, N. Olby n, L. Delucchi

author keywords: Aging; Alzheimer'sdisease; Onehealth; Cognition
MeSH headings : Animals; Cognition Disorders / diagnosis; Cognition Disorders / psychology; Cognitive Dysfunction / diagnosis; Dog Diseases / diagnosis; Dogs; Electroencephalography / veterinary; Humans; Neurodegenerative Diseases / veterinary; Quality of Life
topics (OpenAlex): Human-Animal Interaction Studies; Neural dynamics and brain function; Neuroscience of respiration and sleep
TL;DR: It is demonstrated that quantitative EEG analysis could aid the diagnosis of CCD, and reinforce the CCD as a translational model of early AD. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022

2022 journal article

Low frequency oscillations drive EEG's complexity changes during wakefulness and sleep

NEUROSCIENCE, 494, 1–11.

author keywords: EEG; sleep-wake cycle; low frequency oscillations
MeSH headings : Animals; Electroencephalography; Neocortex; Rats; Sleep / physiology; Sleep, REM / physiology; Wakefulness / physiology
topics (OpenAlex): Neural dynamics and brain function; Sleep and Wakefulness Research; EEG and Brain-Computer Interfaces
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022

2022 journal article

Static posturography as a novel measure of the effects of aging on postural control in dogs

PLOS ONE, 17(7).

By: A. Mondino n, G. Wagner n, K. Russell n, E. Lobaton n, E. Griffith n, M. Gruen n, B. Lascelles n, N. Olby n

Ed(s): R. Evans

MeSH headings : Acceleration; Aging; Animals; Arthralgia; Dogs; Postural Balance; Reproducibility of Results
topics (OpenAlex): Veterinary Orthopedics and Neurology; Human-Animal Interaction Studies; Scoliosis diagnosis and treatment
TL;DR: It is found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural swayed is affected by morphometric parameters and increases with age and joint pain. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 12, 2022

2021 journal article

Cytotoxic effect of Senecio madagascariensis (Asteraceae) extracts on cancer derived cell lines

Agrociencia Uruguay.

topics (OpenAlex): Plant Toxicity and Pharmacological Properties; Drug-Induced Hepatotoxicity and Protection; Pesticide Exposure and Toxicity
Source: ORCID
Added: February 18, 2025

2021 journal article

EEG Gamma Band Alterations and REM-like Traits Underpin the Acute Effect of the Atypical Psychedelic Ibogaine in the Rat

ACS Pharmacology and Translational Science.

topics (OpenAlex): Psychedelics and Drug Studies; Neurotransmitter Receptor Influence on Behavior; Nicotinic Acetylcholine Receptors Study
Source: ORCID
Added: February 18, 2025

2021 chapter

Effects of Cannabis Consumption on Sleep

In Advances in Experimental Medicine and Biology (Vol. 1297, pp. 147–162).

topics (OpenAlex): Cannabis and Cannabinoid Research; Sleep and Wakefulness Research; Neuroscience and Neuropharmacology Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2021 journal article

Glutamatergic neurons in the preoptic hypothalamus promote wakefulness, destabilize nrem sleep, suppress rem sleep, and regulate cortical dynamics

Journal of Neuroscience, 41(15), 3462–3478.

topics (OpenAlex): Sleep and Wakefulness Research; Sleep and related disorders; Neuroscience of respiration and sleep
Source: ORCID
Added: February 18, 2025

2021 article

Low Frequency Oscillations drive EEG’s complexity changes during wakefulness and sleep

González, J., Mateos, D., Cavelli, M., Mondino, A., Pascovich, C., Torterolo, P., & Rubido, N. (2021, December 17).

By: J. González, D. Mateos*, M. Cavelli*, A. Mondino n, C. Pascovich, P. Torterolo, N. Rubido*

topics (OpenAlex): Neural dynamics and brain function; Sleep and Wakefulness Research; EEG and Brain-Computer Interfaces
Source: ORCID
Added: February 18, 2025

2021 journal article

Sleep Disorders in dogs: A Pathophysiological and Clinical Review

Topics in Companion Animal Medicine, 43, 100516.

By: A. Mondino*, L. Delucchi*, A. Moeser, S. Cerdá-González & G. Vanini*

Contributors: A. Mondino*, L. Delucchi*, A. Moeser, S. Cerdá-González & G. Vanini*

topics (OpenAlex): Sleep and Wakefulness Research; Neuroscience of respiration and sleep; Infant Health and Development
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2021 article

Urethane Anesthesia Exhibits Neurophysiological Correlates of Unconsciousness and is Distinct from Sleep

Mondino, A., González, J., Li, D., Mateos, D., Osorio, L., Cavelli, M., … Torterolo, P. (2021, September 24). (Vol. 9). Vol. 9.

topics (OpenAlex): Sleep and Wakefulness Research; Neural dynamics and brain function; Neuroscience and Neuropharmacology Research
Source: ORCID
Added: February 18, 2025

2020 journal article

Activation of Preoptic GABAergic or Glutamatergic Neurons Modulates Sleep-Wake Architecture, but Not Anesthetic State Transitions

Current Biology, 30(5), 779–787.e4.

By: G. Vanini*, M. Bassana*, M. Mast*, A. Mondino*, I. Cerda*, M. Phyle*, V. Chen*, A. Colmenero*, V. Hambrecht-Wiedbusch*, G. Mashour*

Contributors: G. Vanini*, M. Bassana*, M. Mast*, A. Mondino*, I. Cerda*, M. Phyle*, V. Chen*, A. Colmenero*, V. Hambrecht-Wiedbusch*, G. Mashour*

topics (OpenAlex): Sleep and Wakefulness Research; Circadian rhythm and melatonin; Neuroscience and Neuropharmacology Research
Source: ORCID
Added: February 18, 2025

2020 journal article

Communication Through Coherence by Means of Cross-frequency Coupling

Neuroscience, 449, 157–164.

topics (OpenAlex): Neural dynamics and brain function; Photoreceptor and optogenetics research; EEG and Brain-Computer Interfaces
Source: ORCID
Added: February 18, 2025

2020 journal article

EEG power spectrum daily variations in sleep and wakefulness

Sleep Science.

Alejandra Mondino Vero

Source: ORCID
Added: February 18, 2025

2020 journal article

Electrocortical temporal complexity during wakefulness and sleep: an updated account

Sleep Science.

Alejandra Mondino Vero

topics (OpenAlex): Neural dynamics and brain function; EEG and Brain-Computer Interfaces; Sleep and Wakefulness Research
Source: ORCID
Added: February 18, 2025

2020 journal article

Power and Coherence in the EEG of the Rat: Impact of Behavioral States, Cortical Area, Lateralization and Light/Dark Phases

Clocks & Sleep, 2(4), 536–556.

topics (OpenAlex): Sleep and Wakefulness Research; Neural dynamics and brain function; Neuroscience and Neuropharmacology Research
Source: ORCID
Added: February 18, 2025

2020 article

Power and coherence in the EEG of the rat: impact of behavioral states, cortical area, lateralization and light/dark phases

Mondino, A., Cavelli, M., Gonzalez, J., Osorio, L., Castro-Zaballa, S., Costa, A., … Torterolo, P. (2020, August 25).

topics (OpenAlex): Sleep and Wakefulness Research; Neural dynamics and brain function; Neuroscience and Neuropharmacology Research
Source: ORCID
Added: February 18, 2025

2019 journal article

Acute effect of vaporized Cannabis on sleep and electrocortical activity

Pharmacology Biochemistry and Behavior, 179, 113–123.

topics (OpenAlex): Sleep and Wakefulness Research; Cannabis and Cannabinoid Research; Neuroscience and Neuropharmacology Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2019 journal article

Assesment of tibial nerve somatosensory evoked potentials in dogs with Distemper

Veterinaria (Montevideo).

Alejandra Mondino Vero

topics (OpenAlex): Virology and Viral Diseases; Virus-based gene therapy research; Cardiovascular Conditions and Treatments
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2019 journal article

Cannabis Intoxication in Small Animals. Review

Veterinaria (Montevideo).

Alejandra Mondino Vero

topics (OpenAlex): Cannabis and Cannabinoid Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2019 journal article

Decreased electrocortical temporal complexity distinguishes sleep from wakefulness

Scientific Reports, 9(1).

topics (OpenAlex): Neural dynamics and brain function; Sleep and Wakefulness Research; EEG and Brain-Computer Interfaces
Source: ORCID
Added: February 18, 2025

2019 journal article

Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose

Pharmacology Biochemistry and Behavior, 187.

Contributors: A. Mondino*, S. Fernández*, C. Garcia-Carnelli*, M. Castro*, E. Umpierrez*, P. Torterolo*, A. Falconi*, D. Agrati*

topics (OpenAlex): Cannabis and Cannabinoid Research; Neuroscience of respiration and sleep; Neuroendocrine regulation and behavior
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2018 journal article

Brainstem auditory-evoked response in Cimarrón uruguayo dogs

Journal of Small Animal Practice.

Alejandra Mondino Vero

topics (OpenAlex): Human-Animal Interaction Studies; Marine animal studies overview; Hemispheric Asymmetry in Neuroscience
Source: ORCID
Added: February 18, 2025

2018 journal article

Ibogaine Acute Administration in Rats Promotes Wakefulness, Long-Lasting REM Sleep Suppression, and a Distinctive Motor Profile

Frontiers in Pharmacology, 9(APR).

topics (OpenAlex): Psychedelics and Drug Studies; Neurotransmitter Receptor Influence on Behavior; Biochemical Analysis and Sensing Techniques
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: February 18, 2025

2018 journal article

Power and coherence of cortical high-frequency oscillations during wakefulness and sleep

European Journal of Neuroscience, 48(8), 2728–2737.

topics (OpenAlex): Neural dynamics and brain function; Neuroscience and Neuropharmacology Research; Photoreceptor and optogenetics research
Source: ORCID
Added: February 18, 2025

2017 journal article

Absence of EEG gamma coherence in a local activated cortical state: a conserved trait of REM sleep

Translational Brain Rhythmicity.

Alejandra Mondino Vero

topics (OpenAlex): EEG and Brain-Computer Interfaces; Neural dynamics and brain function
Source: ORCID
Added: February 18, 2025

2016 journal article

Successful PRP and fibrin glue application on a clinical case in an equine

Veterinaria (Montevideo), 52, 2–2. http://www.scielo.edu.uy/scielo.php?script=sci_arttext&pid=S1688-48092016000300002&nrm=iso

By: A. Mondino, K. Yaneselli, O. Ferreira & J. Maisonnave

Source: ORCID
Added: February 18, 2025

Employment

Updated: March 9th, 2025 17:13

2024 - 2027

North Carolina State University Raleigh, NC, US
Neurology Resident Clinical Sciences

2021 - 2023

North Carolina State University Raleigh, NC, US
Postdoctoral Scholar Clinical Sciences

2019 - 2021

University of Michigan Ann Arbor, Michigan, US
Postdoctoral Fellow Anesthesiology

Education

Updated: March 9th, 2025 17:15

Universidad de la República Montevideo, Montevideo Department, UY
PhD Neurosciences

Programa de Desarrollo de las Ciencias Básicas Montevideo, Montevideo, UY
Msc in Neuroscience

Universidad de la Republica Montevideo, Montevideo, UY
Doctor in Veterinary Medicine

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