@article{khan_mondino_russell_case_fefer_woods_olby_gruen_2023, title={A novel task of canine olfaction for use in adult and senior pet dogs}, volume={13}, ISSN={["2045-2322"]}, url={https://europepmc.org/articles/PMC9908929}, DOI={10.1038/s41598-023-29361-x}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Khan, Michael Z. and Mondino, Alejandra and Russell, Katharine and Case, Beth and Fefer, Gilad and Woods, Hope and Olby, Natasha and Gruen, Margaret}, year={2023}, month={Feb} }
 @article{salzman_merten_panek_fefer_mondino_westermeyer_gruen_olby_mowat_2023, title={Age-associated changes in electroretinography measures in companion dogs}, volume={6}, ISSN={["1573-2622"]}, url={https://doi.org/10.1007/s10633-023-09938-7}, DOI={10.1007/s10633-023-09938-7}, abstractNote={{"Label"=>"PURPOSE", "NlmCategory"=>"OBJECTIVE"} To determine the association between age and retinal full-field electroretinographic (ERG) measures in companion (pet) dogs, an important translational model species for human neurologic aging. {"Label"=>"METHODS", "NlmCategory"=>"METHODS"} Healthy adult dogs with no significant ophthalmic abnormalities were included. Unilateral full-field light- and dark-adapted electroretinography was performed using a handheld device, with mydriasis and topical anaesthesia. Partial least squares effect screening analysis was performed to determine the effect of age, sex, body weight and use of anxiolytic medication on log-transformed ERG peak times and amplitudes; age and anxiolytic usage had significant effects on multiple ERG outcomes. Mixed model analysis was performed on data from dogs not receiving anxiolytic medications. {"Label"=>"RESULTS", "NlmCategory"=>"RESULTS"} In dogs not receiving anxiolytics, median age was 118 months (interquartile range 72-140 months, n = 77, 44 purebred, 33 mixed breed dogs). Age was significantly associated with prolonged peak times of a-waves (dark-adapted 3 and 10 cds/m {"sup"=>"2"}  flash p < 0.0001) and b-waves (cone flicker p = 0.03, dark-adapted 0.01 cds/m {"sup"=>"2"}  flash p = 0.001). Age was also significantly associated with reduced amplitudes of a-waves (dark-adapted 3 cds/m {"sup"=>"2"}  flash p < 0.0001, 10 cds/m {"sup"=>"2"}  flash p = 0.005) and b-waves (light-adapted 3 cds/m {"sup"=>"2"}  flash p < 0.0001, dark-adapted 0.01 cds/m {"sup"=>"2"}  flash p = 0.0004, 3 cds/m {"sup"=>"2"}  flash p < 0.0001, 10 cds/m {"sup"=>"2"}  flash p = 0.007) and flicker (light-adapted 30 Hz 3 cds/m {"sup"=>"2"}  p = 0.0004). Within the Golden Retriever breed, these trends were matched in a cross-sectional analysis of 6 individuals that received no anxiolytic medication. {"Label"=>"CONCLUSIONS", "NlmCategory"=>"CONCLUSIONS"} Aged companion dogs have slower and reduced amplitude responses in both rod- and cone-mediated ERG. Consideration of anxiolytic medication use should be made when conducting ERG studies in dogs.}, journal={DOCUMENTA OPHTHALMOLOGICA}, author={Salzman, Michele M. and Merten, Natascha and Panek, Wojciech K. and Fefer, Gilad and Mondino, Alejandra and Westermeyer, Hans D. and Gruen, Margaret E. and Olby, Natasha J. and Mowat, Freya M.}, year={2023}, month={Jun} }
 @article{mondino_ludwig_menchaca_russell_simon_griffith_kis_lascelles_gruen_olby_2023, title={Development and validation of a sleep questionnaire, SNoRE 3.0, to evaluate sleep in companion dogs}, volume={13}, ISSN={["2045-2322"]}, DOI={10.1038/s41598-023-40048-1}, abstractNote={Abstract}, number={1}, journal={SCIENTIFIC REPORTS}, author={Mondino, A. and Ludwig, C. and Menchaca, C. and Russell, K. and Simon, K. E. and Griffith, E. and Kis, A. and Lascelles, B. D. X. and Gruen, M. E. and Olby, N. J.}, year={2023}, month={Aug} }
 @article{khan_mondino_russell_case_fefer_woods_olby_gruen_2023, title={Relationship between engagement with the impossible task, cognitive testing, and cognitive questionnaires in a population of aging dogs}, volume={9}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2022.1052193}, abstractNote={IntroductionThe aim of this study was to evaluate the engagement of aging dogs with a cognitively challenging and potentially frustrating task (the impossible task). Based on previous observations, we predicted that dogs showing signs of cognitive impairment in other cognitive tests and owner-completed questionnaires would show reduced engagement with the task.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Khan, Michael Z. and Mondino, Alejandra and Russell, Katharine and Case, Beth and Fefer, Gilad and Woods, Hope and Olby, Natasha J. and Gruen, Margaret E.}, year={2023}, month={Jan} }
 @article{mondino_catanzariti_mateos_khan_ludwig_kis_gruen_olby_2023, title={Sleep and cognition in aging dogs. A polysomnographic study}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1151266}, abstractNote={IntroductionSleep is fundamental for cognitive homeostasis, especially in senior populations since clearance of amyloid beta (key in the pathophysiology of Alzheimer's disease) occurs during sleep. Some electroencephalographic characteristics of sleep and wakefulness have been considered a hallmark of dementia. Owners of dogs with canine cognitive dysfunction syndrome (a canine analog to Alzheimer's disease) report that their dogs suffer from difficulty sleeping. The aim of this study was to quantify age-related changes in the sleep-wakefulness cycle macrostructure and electroencephalographic features in senior dogs and to correlate them with their cognitive performance.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Mondino, Alejandra and Catanzariti, Magaly and Mateos, Diego Martin and Khan, Michael and Ludwig, Claire and Kis, Anna and Gruen, Margaret E. and Olby, Natasha J.}, year={2023}, month={Apr} }
 @article{mondino_khan_case_fefer_panek_gruen_olby_2023, title={Winning the race with aging: age-related changes in gait speed and its association with cognitive performance in dogs}, volume={10}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2023.1150590}, abstractNote={IntroductionIn humans, gait speed is a crucial component in geriatric evaluation since decreasing speed can be a harbinger of cognitive decline and dementia. Aging companion dogs can suffer from age-related mobility impairment, cognitive decline and dementia known as canine cognitive dysfunction syndrome. We hypothesized that there would be an association between gait speed and cognition in aging dogs.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Mondino, Alejandra and Khan, Michael and Case, Beth and Fefer, Gilad and Panek, Wojciech K. and Gruen, Margaret E. and Olby, Natasha J.}, year={2023}, month={Jun} }
 @article{mondino_gutierrez_gonzalez_mateos_torterolo_olby_delucchi_2022, title={Electroencephalographic signatures of dogs with presumptive diagnosis of canine cognitive dysfunction}, volume={150}, ISSN={["1532-2661"]}, DOI={10.1016/j.rvsc.2022.06.024}, abstractNote={Canine cognitive dysfunction (CCD) is a highly prevalent neurodegenerative disease considered the canine analog of early Alzheimer's disease (AD). Unfortunately, CCD cannot be cured. However, early therapeutic interventions can slow the progression of cognitive decline and improve quality of life of the patients; therefore, early diagnosis is ideal. In humans, electroencephalogram (EEG) findings specific to AD have been described, and some of them have successfully detect early stages of the disease. In this study we characterized the EEG correlates of CCD, and we compared them with the EEGs of healthy aging dogs and dogs at risk of developing CCD. EEG recordings were performed in 25 senior dogs during wakefulness. Dogs were categorized in normal, at risk of CCD or with CCD according to their score in the Rofina questionnaire. We demonstrated that, quantitative EEG can detect differences between normal dogs and dogs with CCD. Dogs with CCD experience a reduction in beta and gamma interhemispheric coherence, and higher Joint Lempel Ziv complexity. Dogs at risk of developing CCD, had higher alpha power and interhemispheric coherence, making these features potential markers of early stages of the disease. These results demonstrate that quantitative EEG analysis could aid the diagnosis of CCD, and reinforce the CCD as a translational model of early AD.}, journal={RESEARCH IN VETERINARY SCIENCE}, author={Mondino, Alejandra and Gutierrez, Mary and Gonzalez, Camila and Mateos, Diego and Torterolo, Pablo and Olby, Natasha and Delucchi, Luis}, year={2022}, month={Dec}, pages={36–43} }
 @article{gonzalez_mateos_cavelli_mondino_pascovich_torterolo_rubido_2022, title={Low frequency oscillations drive EEG's complexity changes during wakefulness and sleep}, volume={494}, ISSN={["1873-7544"]}, DOI={10.1016/j.neuroscience.2022.04.025}, abstractNote={Recently, the sleep-wake states have been analysed using novel complexity measures, complementing the classical analysis of EEGs by frequency bands. This new approach consistently shows a decrease in EEG's complexity during slow-wave sleep, yet it is unclear how cortical oscillations shape these complexity variations. In this work, we analyse how the frequency content of brain signals affects the complexity estimates in freely moving rats. We find that the low-frequency spectrum - including the Delta, Theta, and Sigma frequency bands - drives the complexity changes during the sleep-wake states. This happens because low-frequency oscillations emerge from neuronal population patterns, as we show by recovering the complexity variations during the sleep-wake cycle from micro, meso, and macroscopic recordings. Moreover, we find that the lower frequencies reveal synchronisation patterns across the neocortex, such as a sensory-motor decoupling that happens during REM sleep. Overall, our works shows that EEG's low frequencies are critical in shaping the sleep-wake states' complexity across cortical scales.}, journal={NEUROSCIENCE}, author={Gonzalez, Joaquin and Mateos, Diego and Cavelli, Matias and Mondino, Alejandra and Pascovich, Claudia and Torterolo, Pablo and Rubido, Nicolas}, year={2022}, month={Jul}, pages={1–11} }
 @article{mondino_wagner_russell_lobaton_griffith_gruen_lascelles_olby_2022, title={Static posturography as a novel measure of the effects of aging on postural control in dogs}, volume={17}, ISSN={["1932-6203"]}, url={http://dx.doi.org/10.1371/journal.pone.0268390}, DOI={10.1371/journal.pone.0268390}, abstractNote={Aging is associated with impairment in postural control in humans. While dogs are a powerful model for the study of aging, the associations between age and postural control in this species have not yet been elucidated. The aims of this work were to establish a reliable protocol to measure center of pressure excursions in standing dogs and to determine age-related changes in postural sway. Data were obtained from 40 healthy adult dogs (Group A) and 28 senior dogs (Group B) during seven trials (within one session of data collection) of quiet standing on a pressure sensitive walkway system. Velocity, acceleration, root mean square, 95% ellipse area, range and frequency revolve were recorded as measures of postural sway. In Group A, reliability was assessed with intraclass correlation, and the effect of morphometric variables was evaluated using linear regression. By means of stepwise linear regression we determined that root mean square overall and acceleration in the craniocaudal direction were the best variables able to discriminate between Group A and Group B. The relationship between these two center-of-pressure (COP) measures and the dogs’ fractional lifespan was examined in both groups and the role of pain and proprioceptive deficits was evaluated in Group B. All measures except for frequency revolve showed good to excellent reliability. Weight, height and length were correlated with most of the measures. Fractional lifespan impacted postural control in Group B but not Group A. Joint pain and its interaction with proprioceptive deficits influence postural sway especially in the acceleration in the craniocaudal direction, while fractional lifespan was most important in the overall COP displacement. In conclusion, our study found that pressure sensitive walkway systems are a reliable tool to evaluate postural sway in dogs; and that postural sway is affected by morphometric parameters and increases with age and joint pain.}, number={7}, journal={PLOS ONE}, publisher={Public Library of Science (PLoS)}, author={Mondino, Alejandra and Wagner, Grant and Russell, Katharine and Lobaton, Edgar and Griffith, Emily and Gruen, Margaret and Lascelles, B. Duncan X. and Olby, Natasha Jane}, editor={Evans, RichardEditor}, year={2022}, month={Jul} }