Alison Marie Schaefer

College of Engineering

Works (4)

Updated: April 5th, 2024 14:12

2024 article

Engineering a "muco-trapping" ACE2-immunoglobulin hybrid with picomolar affinity as an inhaled, pan-variant immunotherapy for COVID-19

Tiruthani, K., Cruz-Teran, C., Chan, J. F. W., Ma, A., Mcsweeney, M., Wolf, W., … Lai, S. K. (2024, February 7). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: K. Tiruthani *, C. Cruz-Teran*, J. Chan *, A. Ma  n, M. Mcsweeney, W. Wolf*, S. Yuan*, V. Poon * ...

author keywords: ACE2; antibody; COVID-19; drug delivery; immunodecoy; inhaled delivery; monoclonal antibody; SARS-CoV-2
TL;DR: ACE2‐(G4S)6‐Fc effectively trapped fluorescent SARS‐CoV‐2 virus like particles in fresh human airway mucus and was stably nebulized using a commercial vibrating mesh nebulizer, supporting further development of ACE2‐(G4S)6‐Fc as an inhaled immunotherapy for COVID‐19, as well as other emerging viruses that bind ACE2 for cellular entry. (via Semantic Scholar)
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Added: February 19, 2024

2022 article

Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

McSweeney, M., Stewart, I., Richardson, Z., Kang, H., Park, Y., Kim, C., … Lai, S. (2022, August 30). BIOENGINEERING & TRANSLATIONAL MEDICINE.

By: M. McSweeney *, I. Stewart *, Z. Richardson*, H. Kang *, Y. Park*, C. Kim*, K. Tiruthani *, W. Wolf* ...

author keywords: antiviral; COVID-19; drug delivery; inhaled delivery; mAb; nebulization
TL;DR: It is shown that regdanvimab, a potent neutralizing mAb already approved for COVID-19 in several countries around the world, can effectively trap Sars-CoV-2 virus-like-particles in fresh human airway mucus and substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS-Cov-2 and other respiratory pathologies. (via Semantic Scholar)
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Added: September 12, 2022

2021 journal article

Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception

SCIENCE TRANSLATIONAL MEDICINE, 13(606).

By: B. Shrestha *, A. Schaefer n, Y. Zhu *, J. Saada *, T. Jacobs *, E. Chavez *, S. Omsted, C. Cruz-Teran* ...

MeSH headings : Animals; Contraception; Female; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Male; Pregnancy; Sheep; Sperm Motility; Spermatozoa
TL;DR: Motivated by the greater agglutination potencies of polyvalent immunoglobulins but the bioprocessing ease and stability of Immunoglobulin G (IgG), a panel of sperm-binding IgGs with 6 to 10 antigen-binding fragments isolated from a healthy immune-infertile woman against a unique surface antigen universally present on human sperm are developed. (via Semantic Scholar)
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Added: August 30, 2021

2021 article

The biophysical principles underpinning muco-trapping functions of antibodies

Schaefer, A., & Lai, S. K. (2021, June 26). HUMAN VACCINES & IMMUNOTHERAPEUTICS.

By: A. Schaefer n & S. Lai n

author keywords: Passive immunization; antibodies; mucus
MeSH headings : Antibody-Dependent Cell Cytotoxicity; Immunoglobulin G; Mucins; Mucus / metabolism
TL;DR: The mechanism by which the accumulation of weak Fc-mucin bonds by IgG bound to the surface of a pathogen can result in immobilization of antibody-pathogen complexes, and how trapping in mucus can contribute to protection against foreign pathogens are provided. (via Semantic Scholar)
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Added: August 2, 2021

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