Alison Marie Schaefer
College of Engineering
Works (4)
Updated: April 5th, 2024 14:12
2024 article
Engineering a "muco-trapping" ACE2-immunoglobulin hybrid with picomolar affinity as an inhaled, pan-variant immunotherapy for COVID-19
Tiruthani, K., Cruz-Teran, C., Chan, J. F. W., Ma, A., Mcsweeney, M., Wolf, W., … Lai, S. K. (2024, February 7). BIOENGINEERING & TRANSLATIONAL MEDICINE.
author keywords: ACE2; antibody; COVID-19; drug delivery; immunodecoy; inhaled delivery; monoclonal antibody; SARS-CoV-2
TL;DR:
ACE2‐(G4S)6‐Fc effectively trapped fluorescent SARS‐CoV‐2 virus like particles in fresh human airway mucus and was stably nebulized using a commercial vibrating mesh nebulizer, supporting further development of ACE2‐(G4S)6‐Fc as an inhaled immunotherapy for COVID‐19, as well as other emerging viruses that bind ACE2 for cellular entry.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 19, 2024
2022 article
Stable nebulization and muco-trapping properties of regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19
McSweeney, M., Stewart, I., Richardson, Z., Kang, H., Park, Y., Kim, C., … Lai, S. (2022, August 30). BIOENGINEERING & TRANSLATIONAL MEDICINE.
author keywords: antiviral; COVID-19; drug delivery; inhaled delivery; mAb; nebulization
TL;DR:
It is shown that regdanvimab, a potent neutralizing mAb already approved for COVID-19 in several countries around the world, can effectively trap Sars-CoV-2 virus-like-particles in fresh human airway mucus and substantiate nebulized delivery of human antiviral mAbs as a new paradigm in treating SARS-Cov-2 and other respiratory pathologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 12, 2022
2021 journal article
Engineering sperm-binding IgG antibodies for the development of an effective nonhormonal female contraception
SCIENCE TRANSLATIONAL MEDICINE, 13(606).
MeSH headings : Animals; Contraception; Female; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Male; Pregnancy; Sheep; Sperm Motility; Spermatozoa
TL;DR:
Motivated by the greater agglutination potencies of polyvalent immunoglobulins but the bioprocessing ease and stability of Immunoglobulin G (IgG), a panel of sperm-binding IgGs with 6 to 10 antigen-binding fragments isolated from a healthy immune-infertile woman against a unique surface antigen universally present on human sperm are developed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 30, 2021
2021 article
The biophysical principles underpinning muco-trapping functions of antibodies
Schaefer, A., & Lai, S. K. (2021, June 26). HUMAN VACCINES & IMMUNOTHERAPEUTICS.
author keywords: Passive immunization; antibodies; mucus
MeSH headings : Antibody-Dependent Cell Cytotoxicity; Immunoglobulin G; Mucins; Mucus / metabolism
TL;DR:
The mechanism by which the accumulation of weak Fc-mucin bonds by IgG bound to the surface of a pathogen can result in immobilization of antibody-pathogen complexes, and how trapping in mucus can contribute to protection against foreign pathogens are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 2, 2021
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