Works (93)

Updated: January 22nd, 2025 07:21

2024 journal article

Cocoa and Polyphenol‐Rich Cocoa Fractions Fail to Improve Acute Colonic Inflammation in Dextran Sulfate Sodium‐Treated Mice

Molecular Nutrition & Food Research, 68(15).

By: D. Weikart*, K. Coleman*, M. Sweet n, A. McAmis n, H. Hopfer*, A. Neilson n, J. Lambert*

author keywords: cocoa; dextran sulfate sodium; inflammation; polyphenols; ulcerative colitis
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: July 17, 2024

2024 journal article

Phenotype variability in diet-induced obesity and response to (−)-epigallocatechin gallate supplementation in a Diversity Outbred mouse cohort: A model for exploring gene x diet interactions for dietary bioactives

Nutrition Research, 133, 78–93.

By: M. Sweet n, L. Iglesias-Carres n, P. Ellsworth*, J. Carter*, D. Nielsen n, D. Aylor n, J. Tessem*, A. Neilson n

author keywords: EGCG; Diversity Outbred; Gene x environment; Phenotype; Genetic polymorphism
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 13, 2025

2024 journal article

The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice

Nutrition Research, 131, 135–146.

By: K. Racine n, L. Iglesias-Carres n, J. Herring*, K. Wieland*, P. Ellsworth*, J. Tessem*, M. Ferruzzi*, C. Kay*, A. Neilson n

author keywords: Diabetes; Insulin; Beta cells; Sexual dimorphism; High-fat diet
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: October 28, 2024

2023 journal article

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health. METABOLITES, 13(7).

By: E. Krueger*, L. Griffin n, J. Beales*, T. Lloyd*, N. Brown*, W. Elison*, C. Kay n, A. Neilson n, J. Tessem*

author keywords: gut microbiome; phytochemicals; flavanol metabolites; glucose sensitivity; responder analysis; personalized nutrition
TL;DR: It is concluded that metabolite bioactivity on GSIS capacity is less related to flavanol supplementation or antibiotic treatment and may be more associated with the unique microbiome or metabolome of each animal, suggesting flavanol metabolite activities are individualized and point to the need for personalized nutrition practices. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 14, 2023

2023 article

Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N-oxide by modulating gut microbes

Satheesh Babu, A. K., Petersen, C., Iglesias-Carres, L., Paz, H. A., Wankhade, U. D., Neilson, A. P., & Anandh Babu, P. V. (2023, November 3). BIOFACTORS, Vol. 11.

By: A. Satheesh Babu*, C. Petersen*, L. Iglesias-Carres n, H. Paz*, U. Wankhade*, A. Neilson n, P. Anandh Babu*

author keywords: blueberry; chlorogenic acid; gut microbes; strawberry; trimethylamine; trimethylamine N-oxide
TL;DR: Dietary blueberries increased the abundance of bacterial taxa that are negatively associated with circulating TMA/TMAO suggesting the role of gut microbes and phenolic profiling indicates that this effect could be due to chlorogenic acid and increased phenolic contents in blueberries. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 27, 2023

2023 journal article

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 120.

By: L. Iglesias-Carres n, S. Chadwick-Corbin n, M. Sweet n & A. Neilson n

author keywords: Atherosclerosis; Cardiovascular disease; FMO3; Trimethylamine; Trimethylamine N-oxide
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 2, 2024

2023 content posted

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2023 article

Gut Microbiota Depletion Using Antibiotics to Investigate Diet-Derived Microbial Metabolites: An Efficient Strategy

Babu, A. K. S., Petersen, C., Paz, H. A., Iglesias-Carres, L., Li, Y., Zhong, Y., … Babu, P. V. A. (2023, December 6). MOLECULAR NUTRITION & FOOD RESEARCH, Vol. 12.

By: A. Babu*, C. Petersen*, H. Paz*, L. Iglesias-Carres n, Y. Li*, Y. Zhong*, A. Neilson n, U. Wankhade*, P. Babu*

author keywords: antibiotics; diet-derived microbial metabolites; gut microbes; metabolic health; trimethylamine; trimethylamine N-oxide
TL;DR: This strategy effectively depletes gut microbes and suppresses the production of microbial metabolites in mice without affecting their metabolic health. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 18, 2023

2023 journal article

In vitro evidences of the globe artichoke antioxidant, cardioprotective and neuroprotective effects

Journal of Functional Foods, 107, 105674.

author keywords: Artichoke; Polyphenols; Antiaging; TMAO; Neuroprotective
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 28, 2023

2023 journal article

Mechanism of off-color formation in potato chips fried in oil systems containing ascorbic acid as a stabilizer

LWT-FOOD SCIENCE AND TECHNOLOGY, 179.

By: L. Iglesias-Carres n, K. Racine n, S. Chadwick n, C. Nunn n, S. Kalambur*, A. Neilson n, M. Ferruzzi*

author keywords: Amino acid; Maillard reaction; BHT; Rosemary; Carnosic acid; Tocopherol; Moisture; Solubility; Citric acid; Canola oil
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 12, 2023

2022 article

Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using in vitro gastrointestinal digestion and anaerobic fecal fermentation models

Hayes, M., Mohamedshah, Z., Chadwick-Corbin, S., Hoskin, R., Iorizzo, M., Lila, M. A., … Ferruzzi, M. G. (2022, March 8). FOOD & FUNCTION, Vol. 13.

MeSH headings : Anaerobiosis; Caco-2 Cells; Carotenoids / metabolism; Chlorophyll; Digestion; Fermentation; Health Promotion; Humans; Powders; Spinacia oleracea / metabolism
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 31, 2022

2022 journal article

Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model

Food & Function, 13(8), 4315–4330.

By: Z. Mohamedshah n, M. Hayes n, S. Chadwick-Corbin n, A. Neilson n & M. Ferruzzi n

MeSH headings : Caco-2 Cells; Digestion; Fermentation; Fruit / chemistry; Gastrointestinal Microbiome; Humans; Phenols / analysis; Vitis / metabolism
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 4, 2022

2022 article

Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2022, January 31). (Vol. 1). Vol. 1.

By: K. Racine n, L. Iglesias-Carres n, J. Herring*, M. Ferruzzi n, C. Kay n, J. Tessem, A. Neilson n

Source: ORCID
Added: February 2, 2022

2022 journal article

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

Biochemical and Biophysical Research Communications, 626, 205–210.

author keywords: BTBR; Ob/ob; Type-2 diabetes; Flavanol; Insulin; Beta cell
MeSH headings : Animals; Cacao; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hyperglycemia; Hyperinsulinism; Male; Mice; Obesity; Pilot Projects; Plant Extracts / pharmacology; Plant Extracts / therapeutic use
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: October 17, 2022

2022 article

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: a pilot study

Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2022, April 27).

By: K. Racine, L. Iglesias-Carres, J. Herring*, M. Ferruzzi, C. Kay, J. Tessem*, A. Neilson*

Source: ORCID
Added: January 21, 2025

2022 journal article

Effect of processing on the anti-inflammatory efficacy of cocoa in a high fat diet-induced mouse model of obesity

The Journal of Nutritional Biochemistry, 109, 109117.

By: D. Weikart*, V. Indukuri*, K. Racine n, K. Coleman*, J. Kovac*, D. Cockburn*, H. Hopfer*, A. Neilson n, J. Lambert*

author keywords: Cocoa; sex differences; roasting; fermentation; obesity; inflammation
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Body Weight; Cacao; Chocolate; Diet, High-Fat / adverse effects; Disease Models, Animal; Food Ingredients; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Polyphenols / pharmacology
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: October 11, 2022

2022 review

Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?

[Review of ]. FRONTIERS IN NEUROSCIENCE, 16.

By: C. Cheatham*, D. Nieman*, A. Neilson n & M. Lila n

author keywords: age-related; cognition; neuroprotective; phenolic metabolites; prebiotic flavonoids; exercise; microbiome
TL;DR: There is a potential for combined impacts of flavonoids intake and physical exertion on cognitive function, as modulated by the gut microbiome, and that the combination of a flavonoid-rich diet and routine aerobic exercise may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the Gut microbiome. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022

2022 article

Phenolic-rich beverages reduce bacterial TMA formation in an ex vivo-in vitro colonic fermentation model

Iglesias-Carres, L., Racine, K. C., & Neilson, A. P. (2022, July 11). FOOD & FUNCTION, Vol. 7.

By: L. Iglesias-Carres n, K. Racine n & A. Neilson n

MeSH headings : Atherosclerosis / metabolism; Bacteria / metabolism; Beverages; Chlorogenic Acid; Choline / metabolism; Coffee; Fermentation; Humans; Methylamines / metabolism
TL;DR: Regular cocoa and coffee consumption could be a nutritional strategy able to reduce TMAO levels, and fractionating digested bioactive beverages determined that those fractions rich in chlorogenic acid were the most bioactive. (via Semantic Scholar)
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Added: July 26, 2022

2022 article

Phenolic-rich beverages reduce bacterial TMA formation in an ex vivo-in vitro colonic fermentation model

Iglesias-Carres, L., Racine, K., & Neilson, A. (2022, April 29).

By: L. Iglesias-Carres n, K. Racine n & A. Neilson n

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Source: ORCID
Added: January 21, 2025

2022 content posted

Phenolic-rich beverages reduce bacterial TMA formation in an ex vivo-in vitro colonic fermentation model

By: L. Iglesias-Carres n, K. Racine n & A. Neilson n

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Added: January 21, 2025

2022 journal article

Potential of Phenolic Compounds and Their Gut Microbiota-Derived Metabolites to Reduce TMA Formation: Application of an In Vitro Fermentation High-Throughput Screening Model

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(10), 3207–3218.

author keywords: atherosclerosis; food bioactives; gut microbiota metabolites; phenolic compounds; TMA
MeSH headings : Choline / metabolism; Fermentation; Gastrointestinal Microbiome; High-Throughput Screening Assays; Humans; Methylamines
TL;DR: Overall, caffeic acid, catechin, and epicatechin were the most effective noncytotoxic inhibitors of choline use and TMA production, and these compounds are proposed as lead bioactives to test in vivo. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 18, 2022

2022 article

Potential of phenolic compounds and their gut microbiota-derived metabolites to reduce microbial TMA formation: Application of an in vitro fermentation high throughput screening model

Iglesias-Carres, L., Krueger, E., Herring, J., Tessem, J., & Neilson, A. (2022, January 11).

Source: ORCID
Added: January 21, 2025

2022 content posted

Potential of phenolic compounds and their gut microbiota-derived metabolites to reduce microbial TMA formation: Application of an in vitro fermentation high throughput screening model

Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2022 article

Potential of phenolic compounds and their gut microbiota-derived metabolites to reduce microbial TMA formation: Application of an in vitro fermentation high throughput screening model

Iglesias-Carres, L., Krueger, E., Herring, J., Tessem, J., & Neilson, A. (2022, January 11). (Vol. 1). Vol. 1.

Source: ORCID
Added: January 21, 2025

2022 journal article

Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice

Journal of Applied Physiology, 133(4), 798–813.

By: V. Brunt*, N. Greenberg*, Z. Sapinsley*, A. Casso*, J. Richey*, N. VanDongen*, R. Gioscia-Ryan*, B. Ziemba* ...

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2021 journal article

An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder

Scientific Reports, 11(1).

By: M. Virdee*, N. Saini*, C. Kay n, A. Neilson n, S. Kwan*, K. Helfrich*, S. Mooney*, S. Smith*

MeSH headings : Animals; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders / blood; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / microbiology; Gastrointestinal Microbiome; Male; Mice; Mothers; Pregnancy
TL;DR: The maternal microbiome and its MDPs are a previously unrecognized influence upon the pathologies that typify PAE, and are concluded to constitute a characteristic biosignature that distinguishes PAE. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: February 10, 2021

2021 article

Cocoa Extract Exerts Sex-Specific Effects in an Aggressive Hyper-Glycemia Model: A Pilot Study

Racine, K. C., Iglesias-Carres, L., Herring, J. A., Ferruzzi, M. G., Kay, C. D., Tessem, J. S., & Neilson, A. P. (2021, December 7). (Vol. 12). Vol. 12.

By: K. Racine n, L. Iglesias-Carres n, J. Herring*, M. Ferruzzi n, C. Kay n, J. Tessem, A. Neilson n

Source: ORCID
Added: December 10, 2021

2021 content posted

Development of a High Throughput Method to Study the Inhibitory Effect of Phytochemicals on Trimethylamine Formation

Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2021 journal article

Development of a High-Throughput Method to Study the Inhibitory Effect of Phytochemicals on Trimethylamine Formation

Nutrients.

Source: ORCID
Added: January 21, 2025

2021 journal article

Fasting and postprandial trimethylamine N-oxide in sedentary and endurance-trained males following a short-term high-fat diet

PHYSIOLOGICAL REPORTS, 9(16).

By: C. Steele*, M. Baugh*, L. Griffin n, A. Neilson n, B. Davy*, M. Hulver*, K. Davy*

author keywords: endurance-trained; high-fat diet; sedentary; trimethylamine N-oxide
MeSH headings : Adolescent; Adult; Cardiometabolic Risk Factors; Diet, High-Fat / adverse effects; Dietary Fats / metabolism; Endurance Training; Fasting / metabolism; Humans; Male; Methylamines / blood; Postprandial Period; Sedentary Behavior
TL;DR: Plasma TMAO and TMA‐moiety concentrations were measured using isocratic ultraperformance liquid chromatography‐tandem mass spectrometry and VO2max was significantly higher in the endurance‐trained compared with sedentary males, and future studies are needed to identify the effects of endurance training on T MAO production. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2021 journal article

Gut Metabolite Trimethylamine N-Oxide Protects INS-1 beta-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions

BIOMOLECULES, 11(12).

By: E. Krueger*, J. Beales*, K. Russon*, W. Elison*, J. Davis*, J. Hansen*, A. Neilson n, J. Hansen*, J. Tessem*

author keywords: beta cell; islet; glucolipotoxicity (GLT); glucose stimulated insulin secretion (GSIS); unfolded protein response (UPR); type 2 diabetes (T2D)
MeSH headings : Animals; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Diabetes Mellitus, Type 2 / metabolism; Diabetes Mellitus, Type 2 / prevention & control; Endoplasmic Reticulum Stress; Endoribonucleases / metabolism; Female; Gastrointestinal Microbiome; Gene Expression Regulation / drug effects; Insulin / metabolism; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / drug effects; Insulin-Secreting Cells / metabolism; Methylamines / pharmacology; Models, Biological; Multienzyme Complexes / metabolism; Oxidative Stress; Primary Cell Culture; Protein Serine-Threonine Kinases / metabolism; Rats
TL;DR: Novel results demonstrate that TMAO protects β-cell function and suggest that T MAO may play a beneficial molecular role in diet-induced T2D conditions. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 10, 2022

2021 journal article

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Hypertension, 78(2), 499–511.

By: V. Brunt*, A. Casso*, R. Gioscia-Ryan*, Z. Sapinsley*, B. Ziemba*, Z. Clayton*, A. Bazzoni*, N. VanDongen* ...

author keywords: advanced glycation end products; arterial stiffness; gut microbiota; pulse wave velocity
MeSH headings : Adolescent; Adult; Age Factors; Aged; Aging / blood; Animals; Aorta / drug effects; Aorta / physiology; Blood Pressure / drug effects; Blood Pressure / physiology; Female; Humans; Male; Methylamines / administration & dosage; Methylamines / blood; Mice; Middle Aged; Pulse Wave Analysis; Vascular Stiffness / drug effects; Vascular Stiffness / physiology; Young Adult
TL;DR: Ex vivo incubation of aortic rings with TMAO increased intrinsic stiffness, which was attenuated by the advanced glycation end-products crosslink breaker alagebrium and prevented by inhibition of superoxide signaling, which together increase intrinsic wall stiffness. (via Semantic Scholar)
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Added: July 19, 2021

2021 journal article

Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro

Nutrition and Cancer, 74(1), 194–210.

By: L. Griffin n, S. Kohrt*, A. Rathore n, C. Kay n, M. Grabowska* & A. Neilson n

MeSH headings : Animals; Chromatography, Liquid; Gastrointestinal Microbiome; Polyphenols / analysis; Rats; Tandem Mass Spectrometry; Urinary Bladder Neoplasms / drug therapy
TL;DR: It is suggested that microbial metabolites may be the primary compounds responsible for chemoprevention in uroepithelial cell following flavanol consumption, highlighting the potential for exploiting knowledge about individual genetics, microbiome profiles, flavonoid metabolism profiles, tumor characteristics, etc. to design personalized dietary interventions for cancer prevention and/or adjuvant therapy to reduce bladder cancer incidence and improve outcomes. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: February 10, 2021

2021 article

Potential of phenolic compounds and their gut microbiota-derived metabolites to reduce microbial TMA formation: Application of an in vitro fermentation high throughput screening model

Iglesias-Carres, L., Krueger, E., Herring, J., Tessem, J., & Neilson, A. (2021, November 1).

Source: ORCID
Added: January 21, 2025

2021 article

Potential of phenolic compounds and their gut microbiota-derived metabolites to reduce microbial TMA formation: Application of an in vitro fermentation high throughput screening model

Iglesias-Carres, L., Krueger, E., Herring, J., Tessem, J., & Neilson, A. (2021, November 1). (Vol. 11). Vol. 11.

Source: ORCID
Added: January 21, 2025

2021 journal article

Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial

Nutrients, 13(9), 3235.

author keywords: dietary fiber; prebiotics; inulin; diabetes; metabolism; gut microbiota
MeSH headings : Diabetes Mellitus, Type 2 / prevention & control; Dietary Supplements; Female; Humans; Insulin / blood; Insulin Resistance; Inulin / administration & dosage; Inulin / pharmacology; Male; Middle Aged; Pilot Projects; Prebiotics
TL;DR: Despite increases in gut Bifidobacteria, inulin supplementation did not improve peripheral insulin sensitivity, and these findings question the need for larger investigations of inulin and insulin sensitivity in this population. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: October 12, 2021

2021 journal article

Techno-economic analysis of a grape pomace biorefinery: Production of seed oil, polyphenols, and biochar

FOOD AND BIOPRODUCTS PROCESSING, 127, 139–151.

By: Q. Jin*, . Sean F. O'Keefe*, A. Stewart*, A. Neilson n, Y. Kim* & H. Huang*

author keywords: Techno-economic analysis; Grape pomace; Seed oil; Polyphenol; Biochar
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Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 journal article

Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

The Journal of Nutritional Biochemistry, 91, 108600.

author keywords: Atherosclerosis; Cardiovasculardisease; Phytochemicals; TMAO
MeSH headings : Animals; Atherosclerosis / metabolism; Atherosclerosis / therapy; Cardiovascular Diseases / metabolism; Cardiovascular Diseases / therapy; Drug Discovery; Gastrointestinal Microbiome / drug effects; Humans; Lipid Metabolism / drug effects; Methylamines / antagonists & inhibitors; Methylamines / metabolism; Oxidative Stress / drug effects; Phytochemicals / pharmacology
TL;DR: The information provided by this review outlines the current state of the art of the role of phytochemicals as TMAO reducing agents, providing valuable insight to further advance in this field of study. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 26, 2021

2021 journal article

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Food & Function, 12(22), 11077–11105.

By: L. Iglesias-Carres n & A. Neilson n

MeSH headings : Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Genetic Variation / genetics; Humans; Mice; Mice, Inbred Strains / genetics; Nutritional Physiological Phenomena / drug effects; Nutritional Physiological Phenomena / genetics; Phytochemicals / administration & dosage; Phytochemicals / pharmacology; Translational Research, Biomedical
TL;DR: This review will focus on the current work performed with genetically diverse mouse populations, and the research opportunities and advantages that these models can offer to phytochemical research. (via Semantic Scholar)
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Added: November 8, 2021

2020 journal article

Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice

The Journal of Nutritional Biochemistry, 87, 108521.

author keywords: Natural products; Genetic diversity; Diabetes; Flavonoids; Personalized nutrition; Interindividual variation
MeSH headings : Animals; Anti-Obesity Agents / therapeutic use; Collaborative Cross Mice / genetics; Collaborative Cross Mice / physiology; Diet, High-Fat / adverse effects; Disease Models, Animal; Female; Genetic Variation; Male; Obesity / drug therapy; Obesity / etiology; Obesity / genetics; Quercetin / therapeutic use; Sex Factors
TL;DR: How diverse mouse strains respond to diet-induced obesity when fed a representative flavonoid is explored to justify use of genetically diverse Collaborative Cross and Diversity Outbred models which are emerging as invaluable tools in the field of personalized nutrition. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 11, 2021

2020 journal article

Flavone Hispidulin Stimulates Glucagon‐Like Peptide‐1 Secretion and Ameliorates Hyperglycemia in Streptozotocin‐Induced Diabetic Mice

Molecular Nutrition & Food Research, 64(6).

By: Y. Wang*, A. Wang*, H. Alkhalidy*, J. Luo*, E. Moomaw*, A. Neilson n, D. Liu*

author keywords: diabetes; glucagon-like peptide-1; hispidulin; insulin; mice
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Cyclic AMP / metabolism; Cyclic AMP-Dependent Protein Kinases / metabolism; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Eating / drug effects; Flavones / pharmacology; Glucagon-Like Peptide 1 / metabolism; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / pharmacology; Insulin / metabolism; Insulin-Secreting Cells / drug effects; Insulin-Secreting Cells / metabolism; Male; Mice, Inbred C57BL
TL;DR: Hispidulin significantly improved glycemic control in diabetic mice, concomitant with improved insulin release and β-cell survival, and suggest that hispidulin may be a novel dual-action anti-diabetic compound via stimulating GLP-1 secretion and suppressing hepatic glucose production. (via Semantic Scholar)
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Added: February 17, 2020

2020 journal article

Grape pomace and its secondary waste management: Biochar production for a broad range of lead (Pb) removal from water

Environmental Research, 186, 109442.

author keywords: Grape pomace; Biochar; Pb; Adsorption mechanism; Water contamination
MeSH headings : Adsorption; Charcoal; Lead; Vitis; Wastewater; Water
TL;DR: To approach zero solid waste during GP processing, a pyrolysis process was designed for converting GP and its secondary processing wastes to biochars, which were then evaluated for lead (Pb) adsorption from water. (via Semantic Scholar)
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Added: August 3, 2020

2020 journal article

Journal of Nutritional Biochemistry Special Issue: Polyphenols, obesity, and cardiometabolic health

The Journal of Nutritional Biochemistry, 89, 108565.

MeSH headings : Cardiovascular Diseases / prevention & control; Gastrointestinal Microbiome / drug effects; Humans; Obesity / prevention & control; Obesity / therapy; Polyphenols / administration & dosage; Polyphenols / metabolism; Risk Factors; Tea / chemistry
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Added: April 12, 2021

2020 journal article

Modulating Phenolic Bioaccessibility and Glycemic Response of Starch-Based Foods in Wistar Rats by Physical Complexation between Starch and Phenolic Acid

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(46), 13257–13266.

By: M. Li n, L. Griffin n, S. Corbin n, A. Neilson n & M. Ferruzzi n

author keywords: LC-MS; in vitro bioaccessibility; cellular uptake efficiency; postprandial glycemic response; Caco-2 human intestinal cells; starch-phenolic complexes
MeSH headings : Animals; Blood Glucose / metabolism; Caco-2 Cells; Glycemic Index; Humans; Hydroxybenzoates / metabolism; Intestines; Male; Phenols / metabolism; Rats; Rats, Wistar; Solanum tuberosum / metabolism; Starch / analysis; Starch / metabolism; Zea mays / metabolism
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 4, 2021

2020 journal article

Postprandial skeletal muscle metabolism following a high-fat diet in sedentary and endurance-trained males

Journal of Applied Physiology, 128(4), 872–883.

author keywords: exercise; high-fat diet; metabolic flexibility; skeletal muscle; substrate oxidation
MeSH headings : Diet, High-Fat; Endurance Training; Fasting; Humans; Male; Muscle, Skeletal; Postprandial Period
TL;DR: Insight is provided into differing substrate metabolism responses between SED and ET individuals and the role the prevailing diet may play in modulating fasting and postprandial metabolic responses in skeletal muscle is highlighted. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: May 18, 2020

2020 article

Supplemental treatment options for diabetes: how flavanol metabolites improve beta-cell function

Lloyd, T., Griffin, L., Krueger, E., Beales, J., Barlow, A., Sheets, J., … Tessem, J. (2020, April). FASEB JOURNAL, Vol. 34.

By: T. Lloyd*, L. Griffin n, E. Krueger*, J. Beales*, A. Barlow*, J. Sheets*, I. Ekpo*, M. Ross* ...

TL;DR: Data is presented regarding the in vitro effects of these absorbed gut bacteria derived flavanoids on INS‐1 832/13 β‐cell insulin secretion and proliferation and further light is shed on the potential ability of flavanoid and their gut bacteriaderived metabolites to enhance functional β‐ cell mass. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 journal article

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging

GeroScience, 43(1), 377–394.

By: V. Brunt*, T. LaRocca*, A. Bazzoni*, Z. Sapinsley*, J. Miyamoto-Ditmon*, R. Gioscia-Ryan*, A. Neilson*, C. Link*, D. Seals*

author keywords: Cognitive impairment; Inflammation; Astrocyte activation; Brain; Memory
MeSH headings : Aging; Animals; Cognition; Gastrointestinal Microbiome; Methylamines; Mice
TL;DR: The results provide translational insight into a novel pathway that modulates neuro inflammation and cognitive function with aging, and suggest that TMAO might be a promising target for prevention of neuroinflammation and cognitive decline with aging. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: September 14, 2020

2020 journal article

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Hypertension, 76(1), 101–112.

By: V. Brunt*, R. Gioscia-Ryan*, A. Casso*, N. VanDongen*, B. Ziemba*, Z. Sapinsley*, J. Richey*, M. Zigler* ...

author keywords: acetylcholine; aging; brachial artery; microbiota nitric oxide; superoxide
MeSH headings : Acetylcholine / pharmacology; Adolescent; Adult; Aged; Aging / blood; Aging / physiology; Animals; Antioxidants / pharmacology; Ascorbic Acid / pharmacology; Brachial Artery / drug effects; Brachial Artery / physiology; Carotid Arteries / drug effects; Carotid Arteries / physiology; Cyclic N-Oxides / pharmacology; Dietary Supplements; Endothelium, Vascular / drug effects; Gastrointestinal Microbiome; Humans; Methylamines / administration & dosage; Methylamines / blood; Methylamines / toxicity; Mice; Mice, Inbred C57BL; Middle Aged; Nitric Oxide / blood; Nitric Oxide Synthase Type III / metabolism; Oxidative Stress / drug effects; Spin Labels; Superoxides / metabolism; Tyrosine / analogs & derivatives; Tyrosine / blood; Vasodilation / drug effects; Vasodilation / physiology; Young Adult
TL;DR: A clear role of trimethylamine-N-oxide is demonstrated in promoting age-related endothelial dysfunction via oxidative stress through oxidative stress in middle-aged/older adults, which may have implications for prevention of cardiovascular diseases. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: July 27, 2020

2019 journal article

A Mediterranean diet does not alter plasma trimethylamine N-oxide concentrations in healthy adults at risk for colon cancer

FOOD & FUNCTION, 10(4), 2138–2147.

By: L. Griffin*, Z. Djuric*, C. Angiletta*, C. Mitchell*, M. Baugh*, K. Davy*, A. Neilson*

MeSH headings : Adult; Aged; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Bacteria / metabolism; Betaine / blood; Choline / blood; Colonic Neoplasms / blood; Colonic Neoplasms / diet therapy; Colonic Neoplasms / metabolism; Colonic Neoplasms / microbiology; Diet, Mediterranean; Fasting; Female; Gastrointestinal Microbiome; Humans; Male; Methylamines / blood; Middle Aged
TL;DR: It is suggested that broad dietary pattern intervention over six months may not be sufficient for reducing TMAO concentrations in an otherwise healthy population, and disruption of the conversion of dietary TMA to T MAO should be the focus of future studies. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 20, 2020

2019 journal article

Comparison of Common Analytical Methods for the Quantification of Total Polyphenols and Flavanols in Fruit Juices and Ciders

Journal of Food Science, 84(8), 2147–2158.

By: S. Ma*, C. Kim*, A. Neilson n, L. Griffin n, G. Peck*, S. O'Keefe*, A. Stewart*

author keywords: BSA precipitation; DMAC; flavanols; Folin-Ciocalteu; Lowenthal permanganate titration
MeSH headings : Flavanones / analysis; Food Analysis / methods; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Malus / chemistry; Polyphenols / analysis
TL;DR: Results obtained can help manufacturers of fruit‐based products choose the most appropriate analytical method for polyphenol quantification as part of a quality assurance program or to convey information on dietarypolyphenol content to consumers. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 5, 2019

2019 journal article

Compositional Characterization of Different Industrial White and Red Grape Pomaces in Virginia and the Potential Valorization of the Major Components

Foods, 8(12), 667.

By: Q. Jin*, J. O’Hair*, A. Stewart*, S. O’Keefe*, A. Neilson n, Y. Kim*, M. McGuire, A. Lee*, G. Wilder*, H. Huang*

author keywords: grape pomace; chemical composition; fatty acids; polyphenols; carbohydrates; lignin
TL;DR: Considering the valuable extractives and non-extractives of grape pomace and lignin, designing a biorefinery process aiming at fully recover and/or utilize these components is of future significance. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 27, 2020

2019 journal article

Development and Characterization of a Pilot-Scale Model Cocoa Fermentation System Suitable for Studying the Impact of Fermentation on Putative Bioactive Compounds and Bioactivity of Cocoa

Foods.

Source: ORCID
Added: January 21, 2025

2019 journal article

Development of a rapid ultra performance hydrophilic interaction liquid chromatography tandem mass spectrometry method for procyanidins with enhanced ionization efficiency

JOURNAL OF CHROMATOGRAPHY A, 1594, 54–64.

By: K. Racine*, A. Lee*, A. Stewart*, K. Blakeslee* & A. Neilson n

author keywords: Cocoa; Sensitivity; Electrospray ionization; Diol; Ammonium formate
MeSH headings : Biflavonoids / analysis; Biflavonoids / isolation & purification; Catechin / analysis; Catechin / isolation & purification; Chemistry Techniques, Analytical / methods; Chromatography, Liquid; Formates / chemistry; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Proanthocyanidins / analysis; Proanthocyanidins / isolation & purification; Tandem Mass Spectrometry
TL;DR: This method builds upon the foundation set by existing analytical methods and employs new technologies to dramatically increase sample throughput and enhance detection limits and specificity, facilitating improved analysis for procyanidins. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 28, 2019

2019 journal article

Flavanol Polymerization Is a Superior Predictor of α-Glucosidase Inhibitory Activity Compared to Flavanol or Total Polyphenol Concentrations in Cocoas Prepared by Variations in Controlled Fermentation and Roasting of the Same Raw Cocoa Beans

Antioxidants, 8(12), 635.

author keywords: flavan-3-ol; procyanidin; alpha-glucosidase; melanoidin; Maillard reaction
TL;DR: It is demonstrated that cocoa powders are potent inhibitors of α-glucosidase, and non-traditional compositional markers may be better predictors of enzyme inhibitory activity than cocoa native flavanols. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 27, 2020

2019 journal article

Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet

NUTRITION RESEARCH, 66, 32–47.

By: L. Griffin*, D. Fausnacht*, J. Tuzo*, A. Addington*, K. Racine*, H. Zhang*, M. Hughes*, K. England* ...

author keywords: Mean degree of polymerization (mDP); Flavanols; Procyanidins (PCs); Glucose intolerance; Cytokines
MeSH headings : Adipose Tissue / chemistry; Animals; Body Composition / drug effects; Diet, High-Fat / adverse effects; Dietary Supplements; Eating / drug effects; Flavonols / administration & dosage; Glucose Intolerance / prevention & control; Grape Seed Extract / chemistry; Inflammation / prevention & control; Insulin Resistance; Interleukin-6 / analysis; Male; Mice; Mice, Inbred C57BL; Obesity / physiopathology; Pinus / chemistry; Plant Bark / chemistry; Weight Gain / drug effects
TL;DR: Overall, low-dose flavanol extract supplementation, regardless of mean degrees of polymerization, blunted cytokine production despite increased weight gain, suggesting flavanols may be used as complementary interventions to ameliorate increased inflammatory tone in the contexts of obesity and diabetes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 22, 2019

2019 journal article

Preference for and sensitivity to flavanol mean degree of polymerization in model wines is correlated with body composition

Appetite, 144, 104442.

By: L. Griffin n, C. Diako*, L. Miller*, A. Neilson n, C. Ross* & A. Stewart*

author keywords: Astringency; Preference; BMI; Body fat percentage; PROP
MeSH headings : Adipose Tissue; Adult; Body Composition / physiology; Body Mass Index; Body Weight / physiology; Female; Food Preferences / drug effects; Food Preferences / physiology; Humans; Male; Middle Aged; Polymerization; Polyphenols / administration & dosage; Propylthiouracil / administration & dosage; Taste / drug effects; Taste / physiology; Taste Buds / drug effects; Taste Threshold / drug effects; Wine / analysis; Young Adult
TL;DR: The data suggest that weight status in adults is a greater predictor of liking of flavanol-rich foods than bitterness sensitivity (as determined by PROP classification), and that reduced perception of bitterness and astringency associated with weight gain may impact selection and preference for these foods. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: December 9, 2019

2019 journal article

Recovery of protein hydrolysates from brewer’s spent grain using enzyme and ultrasonication

International Journal of Food Science & Technology, 55(1), 357–368.

By: D. Yu*, Y. Sun*, W. Wang*, S. O’Keefe*, A. Neilson*, H. Feng*, Z. Wang*, H. Huang*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2019 journal article

Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans

Metabolism, 103, 154041.

By: S. Bowser*, R. McMillan*, N. Boutagy*, M. Tarpey*, A. Smithson*, K. Osterberg*, A. Neilson*, B. Davy*, K. Davy*, M. Hulver*

author keywords: Skeletal muscle; Substrate oxidation; Metabolic flexibility; High fat diet; Metabolic adaptation
MeSH headings : Adaptation, Physiological / physiology; Adult; Diet, High-Fat; Dietary Fats / pharmacology; Endotoxins / blood; Energy Metabolism / drug effects; Humans; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestines / drug effects; Intestines / pathology; Lipid Metabolism / drug effects; Male; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Permeability; Young Adult
TL;DR: It is demonstrated that in healthy young men, consuming an isocaloric HFD for 5 days increases fasting endotoxin, independent of changes in gut permeability, and these changes in endotoxin are accompanied by a broad effect on skeletal muscle substrate metabolism including increases in postprandial fat oxidation. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: February 27, 2020

2019 journal article

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice

The Journal of Physiology, 597(9), 2361–2378.

By: V. Brunt*, R. Gioscia‐Ryan*, J. Richey*, M. Zigler*, L. Cuevas*, A. Gonzalez*, Y. Vázquez‐Baeza*, M. Battson* ...

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2019 journal article

Trace minerals in tilapia fillets: Status in the United States marketplace and selenium supplementation strategy for improving consumer’s health

PLOS ONE, 14(6), e0217043.

By: R. Farzad*, D. Kuhn*, S. Smith*, S. O’Keefe*, N. Ralston*, A. Neilson*, D. Gatlin*

Ed(s): J. Loor

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2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Does Exercise Alter Gut Microbial Composition? A Systematic Review

Medicine & Science in Sports & Exercise, 51(1), 160–167.

By: C. Mitchell*, B. Davy*, M. Hulver*, A. Neilson*, B. Bennett* & K. Davy*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Free amino acid composition of apple juices with potential for cider making as determined by UPLC-PDA

Journal of the Institute of Brewing, 124(4), 467–476.

By: S. Ma*, A. Neilson*, J. Lahne*, G. Peck*, S. O'Keefe* & A. Stewart*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Impact of short-term flavanol supplementation on fasting plasma trimethylamine N-oxide concentrations in obese adults

Food & Function.

By: C. Angiletta*, L. Griffin*, C. Steele*, D. Baer*, J. Novotny*, K. Davy*, A. Neilson*

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2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 21, 2025

2018 journal article

Integrated Approach for the Valorization of Red Grape Pomace: Production of Oil, Polyphenols, and Acetone–Butanol–Ethanol

ACS Sustainable Chemistry & Engineering, 6(12), 16279–16286.

By: Q. Jin*, A. Neilson*, A. Stewart*, S. O’Keefe*, Y. Kim*, M. McGuire, G. Wilder*, H. Huang*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Inulin Supplementation Does Not Reduce Plasma Trimethylamine N-Oxide Concentrations in Individuals at Risk for Type 2 Diabetes

Nutrients, 10(6), 793.

By: M. Baugh*, C. Steele*, C. Angiletta*, C. Mitchell*, A. Neilson*, B. Davy*, M. Hulver*, K. Davy*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Juice Clarification with Pectinase Reduces Yeast Assimilable Nitrogen in Apple Juice without Affecting the Polyphenol Composition in Cider

Journal of Food Science, 83(11), 2772–2781.

By: S. Ma*, A. Neilson*, J. Lahne*, G. Peck*, S. O'Keefe*, E. Hurley*, A. Sandbrook*, A. Stewart*

Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2018 journal article

Potential Health Effects of Tea

Nutrition Today, 53(5), 213–228.

By: T. Haufe*, K. Ho*, M. Ferruzzi* & A. Neilson*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Production and Polyphenolic Composition of Tea

Nutrition Today, 53(6), 268–278.

By: K. Ho*, T. Haufe*, M. Ferruzzi* & A. Neilson*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2018 journal article

Production of omega-3 enriched tilapia through the dietary use of algae meal or fish oil: Improved nutrient value of fillet and offal

PLOS ONE, 13(4), e0194241.

By: T. Stoneham*, D. Kuhn*, D. Taylor*, A. Neilson*, S. Smith*, D. Gatlin*, H. Chu*, S. O’Keefe*

Ed(s): J. Loor

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2017 journal article

Alterations to metabolically active bacteria in the mucosa of the small intestine predict anti-obesity and anti-diabetic activities of grape seed extract in mice

Food & Function, 8(10), 3510–3522.

By: L. Griffin*, K. Witrick*, C. Klotz*, M. Dorenkott*, K. Goodrich*, G. Fundaro*, R. McMillan*, M. Hulver*, M. Ponder*, A. Neilson*

MeSH headings : Animals; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Blood Glucose / metabolism; Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Diabetes Mellitus / microbiology; Diet, High-Fat / adverse effects; Gastrointestinal Microbiome / drug effects; Grape Seed Extract / administration & dosage; Humans; Insulin / metabolism; Intestine, Small / metabolism; Intestine, Small / microbiology; Male; Mice; Mice, Inbred C57BL; Obesity / drug therapy; Obesity / metabolism; Obesity / microbiology; Vitis / chemistry
TL;DR: Grape seed extract can prevent early changes in glucose tolerance and alter small intestinal gut microbiota, prior to the onset of skeletal muscle metabolic derangements, when grape seed extract is consumed at a low dose in the context of a moderately high fat diet. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018

2017 journal article

Cellulose-based amorphous solid dispersions enhance rifapentine delivery characteristics in vitro

Carbohydrate Polymers, 182, 149–158.

By: C. Winslow*, B. Nichols*, D. Novo*, L. Mosquera-Giraldo*, L. Taylor*, K. Edgar*, A. Neilson*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2017 journal article

Flavanol concentrations do not predict dipeptidyl peptidase-IV inhibitory activities of four cocoas with different processing histories

Food & Function, 8(2), 746–756.

By: C. Ryan*, W. Khoo*, A. Stewart*, S. O'Keefe*, J. Lambert* & A. Neilson*

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2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2017 journal article

Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration

The Journal of Nutritional Biochemistry, 49, 30–41.

By: T. Rowley*, B. Bitner*, J. Ray*, D. Lathen*, A. Smithson*, B. Dallon*, C. Plowman*, B. Bikman* ...

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2017 journal article

Pre-meal inulin consumption does not affect acute energy intake in overweight and obese middle-aged and older adults: A randomized controlled crossover pilot trial

Nutrition and Health, 23(2), 75–81.

By: K. Smiljanec*, C. Mitchell*, O. Privitera*, A. Neilson*, K. Davy* & B. Davy*

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7. Affordable and Clean Energy (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2016 journal article

Cranberry extract attenuates hepatic inflammation in high-fat-fed obese mice

The Journal of Nutritional Biochemistry, 37, 60–66.

By: S. Glisan*, C. Ryan*, A. Neilson* & J. Lambert*

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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2016 journal article

Evaluation of different solvents to extract antibacterial compounds from jalapeño peppers

Food Science & Nutrition, 5(3), 497–503.

By: K. Bacon*, R. Boyer*, C. Denbow*, S. O'Keefe*, A. Neilson* & R. Williams*

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6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2016 journal article

Grape powder attenuates the negative effects of GLP-1 receptor antagonism by exendin-3 (9–39) in a normoglycemic mouse model

Food & Function, 7(6), 2692–2705.

By: T. Haufe*, A. Gilley*, K. Goodrich*, C. Ryan*, A. Smithson*, M. Hulver*, D. Liu*, A. Neilson*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2016 journal article

Loss of Native Flavanols during Fermentation and Roasting Does Not Necessarily Reduce Digestive Enzyme-Inhibiting Bioactivities of Cocoa

Journal of Agricultural and Food Chemistry, 64(18), 3616–3625.

By: C. Ryan*, W. Khoo*, L. Ye*, J. Lambert*, S. O’Keefe* & A. Neilson*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2016 journal article

Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders

The Journal of Nutritional Biochemistry, 35, 1–21.

By: K. Strat*, T. Rowley*, A. Smithson*, J. Tessem*, M. Hulver*, D. Liu*, B. Davy*, K. Davy*, A. Neilson*

Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2016 journal article

Novel cellulose-based amorphous solid dispersions enhance quercetin solution concentrations in vitro

Carbohydrate Polymers, 157, 86–93.

By: A. Gilley*, H. Arca*, B. Nichols*, L. Mosquera-Giraldo*, L. Taylor*, K. Edgar*, A. Neilson*

Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2015 journal article

Analysis of Cocoa Proanthocyanidins Using Reversed Phase High-Performance Liquid Chromatography and Electrochemical Detection: Application to Studies on the Effect of Alkaline Processing

Journal of Agricultural and Food Chemistry, 63(25), 5970–5975.

By: T. Stanley*, A. Smithson*, A. Neilson*, R. Anantheswaran* & J. Lambert*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2015 journal article

Cocoa procyanidins with different degrees of polymerization possess distinct activities in models of colonic inflammation

The Journal of Nutritional Biochemistry, 26(8), 827–831.

By: Z. Bitzer*, S. Glisan*, M. Dorenkott*, K. Goodrich*, L. Ye*, S. O’Keefe*, J. Lambert*, A. Neilson*

Sources: ORCID, Crossref, NC State University Libraries
Added: January 21, 2025

2015 journal article

Contribution of Chlorophyll to Photooxidation of Soybean Oil at Specific Visible Wavelengths of Light

Journal of Food Science, 80(2).

By: L. Bianchi*, S. Duncan*, J. Webster*, A. Neilson* & S. O'Keefe*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2015 journal article

Pan-colonic pharmacokinetics of catechins and procyanidins in male Sprague–Dawley rats

The Journal of Nutritional Biochemistry, 26(10), 1007–1014.

By: K. Goodrich*, A. Smithson*, A. Ickes* & A. Neilson*

Source: ORCID
Added: January 21, 2025

2015 journal article

Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans

Nutrition Research, 35(10), 858–864.

By: N. Boutagy*, A. Neilson*, K. Osterberg*, A. Smithson*, T. Englund*, B. Davy*, M. Hulver*, K. Davy*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2014 journal article

Comprehensive quantitative analysis of purines and pyrimidines in the human malaria parasite using ion-pairing ultra-performance liquid chromatography–mass spectrometry

Journal of Chromatography B, 967, 127–133.

By: C. Laourdakis*, E. Merino*, A. Neilson* & M. Cassera*

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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2014 journal article

Oligomeric Cocoa Procyanidins Possess Enhanced Bioactivity Compared to Monomeric and Polymeric Cocoa Procyanidins for Preventing the Development of Obesity, Insulin Resistance, and Impaired Glucose Tolerance during High-Fat Feeding

Journal of Agricultural and Food Chemistry, 62(10), 2216–2227.

By: M. Dorenkott*, L. Griffin*, K. Goodrich*, K. Thompson-Witrick*, G. Fundaro*, L. Ye*, J. Stevens*, M. Ali* ...

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2012 journal article

Chronic administration of dietary grape seed extract increases colonic expression of gut tight junction protein occludin and reduces fecal calprotectin: a secondary analysis of healthy Wistar Furth rats

Nutrition Research, 32(10), 787–794.

By: K. Goodrich*, G. Fundaro*, L. Griffin*, A. Grant*, M. Hulver*, M. Ponder*, A. Neilson*

Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2010 journal article

Plasma levels of resistin-like molecule beta in humans

Cancer Epidemiology, 35(5), 485–489.

By: A. Neilson*, Z. Djuric*, S. Land* & I. Kato*

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3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

2010 journal article

Tea catechin auto-oxidation dimers are accumulated and retained by Caco-2 human intestinal cells

Nutrition Research, 30(5), 327–340.

By: A. Neilson*, B. Song*, T. Sapper*, J. Bomser* & M. Ferruzzi*

author keywords: Catechins; Epicatechins; Auto-oxidation; Tea; Dimers; Theasinensin; P-2; Caco-2
MeSH headings : Benzopyrans / chemistry; Benzopyrans / metabolism; Caco-2 Cells; Camellia sinensis / chemistry; Catechin / analogs & derivatives; Catechin / chemistry; Catechin / metabolism; Chromatography, Liquid; Dimerization; Epithelial Cells / metabolism; Humans; Intestinal Absorption; Intestinal Mucosa / metabolism; Mass Spectrometry; Oxidation-Reduction; Phenols / chemistry; Phenols / metabolism; Polymers / chemistry; Polymers / metabolism; Tea / chemistry
TL;DR: Data suggest that catechin dimers present in the gut lumen may be readily absorbed by intestinal epithelium, suggesting intracellular oxidative conversion of THSNs to P-2. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2009 journal article

Influence of Chocolate Matrix Composition on Cocoa Flavan-3-ol Bioaccessibility In Vitro and Bioavailability in Humans

Journal of Agricultural and Food Chemistry, 57(20), 9418–9426.

By: A. Neilson*, J. George, E. Janle, R. Mattes, R. Rudolph, N. Matusheski, M. Ferruzzi*

author keywords: Theobroma cacao; food matrix; chocolate; catechin; epicatechin; bioavailability; in vitro digestion; Caco-2 cells
MeSH headings : Beverages / analysis; Biological Availability; Cacao / chemistry; Caco-2 Cells; Candy / analysis; Cross-Over Studies; Female; Flavonoids / administration & dosage; Flavonoids / blood; Flavonoids / pharmacokinetics; Humans; Male; Milk Proteins / analysis; Plant Extracts / administration & dosage; Plant Extracts / blood; Plant Extracts / pharmacokinetics; Young Adult
TL;DR: The data suggest that bioavailability of cocoa flavan-3-ols is likely similar from typical commercial cocoa based foods and beverages, but that the physical form and sucrose content may influence T(MAX) and C(MAX). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2006 journal article

High-throughput analysis of catechins and theaflavins by high performance liquid chromatography with diode array detection

Journal of Chromatography A, 1132(1-2), 132–140.

By: A. Neilson*, R. Green*, K. Wood* & M. Ferruzzi*

author keywords: catechins; theaflavins; flavonoids; tea; HPLC-DAD; LC-ESI-MS
MeSH headings : Biflavonoids / analysis; Biflavonoids / chemistry; Catechin / analysis; Catechin / chemistry; Chromatography, High Pressure Liquid / instrumentation; Chromatography, High Pressure Liquid / methods; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods; Tea / chemistry
TL;DR: Two new RP-C18 methods for HPLC-DAD analysis of tea flavonoids were developed to facilitate separation of catechins within 5 min and separation ofcatechins and theaflavins within 10 min total analysis time, representing a 2-4-fold reduction in HPLC analysis time from existing analytical methods. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2006 journal article

Sensory and Nutritional Quality of Dehydrated Potato Flakes in Long‐Term Storage

Journal of Food Science, 71(6).

By: A. Neilson*, H. Pahulu*, L. Ogden* & O. Pike*

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 22, 2025

Employment

Updated: March 18th, 2019 15:49

2019 - present

North Carolina State University Kannapolis, North Carolina, US
Associate Professor Plants for Human Health Institute

2011 - 2018

Virginia Polytechnic Institute and State University Blacksburg, VA, US
Assistant Professor Food Science & Technology

2009 - 2011

University of Michigan Medical School Ann Arbor, MI, US
Postdoctoral fellow Family Medicine

Education

Updated: October 10th, 2014 14:45

2005 - 2009

Purdue University West Lafayette, IN, US
PfD Food Science

1997 - 2005

Brigham Young University Provo, UT, US
BS Food Science

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