Andrew Peter Neilson

Works (40)

Updated: July 18th, 2024 05:01

2024 article

Cocoa and Polyphenol-Rich Cocoa Fractions Fail to Improve Acute Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice

Weikart, D. K., Coleman, K. M., Sweet, M. G., Mcamis, A. M., Hopfer, H., Neilson, A. P., & Lambert, J. D. (2024, July 4). MOLECULAR NUTRITION & FOOD RESEARCH.

By: D. Weikart, K. Coleman, M. Sweet, A. Mcamis, H. Hopfer, A. Neilson , J. Lambert

author keywords: cocoa; dextran sulfate sodium; inflammation; polyphenols; ulcerative colitis
Source: Web Of Science
Added: July 17, 2024

2023 journal article

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health. METABOLITES, 13(7).

By: E. Krueger *, L. Griffin n, J. Beales*, T. Lloyd*, N. Brown *, W. Elison *, C. Kay n , A. Neilson n , J. Tessem *

author keywords: gut microbiome; phytochemicals; flavanol metabolites; glucose sensitivity; responder analysis; personalized nutrition
TL;DR: It is concluded that metabolite bioactivity on GSIS capacity is less related to flavanol supplementation or antibiotic treatment and may be more associated with the unique microbiome or metabolome of each animal, suggesting flavanol metabolite activities are individualized and point to the need for personalized nutrition practices. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 14, 2023

2023 article

Blueberry intervention mitigates detrimental microbial metabolite trimethylamine N-oxide by modulating gut microbes

Satheesh Babu, A. K., Petersen, C., Iglesias-Carres, L., Paz, H. A., Wankhade, U. D., Neilson, A. P., & Anandh Babu, P. V. (2023, November 3). BIOFACTORS.

By: A. Satheesh Babu*, C. Petersen*, L. Iglesias-Carres  n, H. Paz *, U. Wankhade *, A. Neilson n , P. Anandh Babu *

author keywords: blueberry; chlorogenic acid; gut microbes; strawberry; trimethylamine; trimethylamine N-oxide
TL;DR: Dietary blueberries increased the abundance of bacterial taxa that are negatively associated with circulating TMA/TMAO suggesting the role of gut microbes and phenolic profiling indicates that this effect could be due to chlorogenic acid and increased phenolic contents in blueberries. (via Semantic Scholar)
Source: Web Of Science
Added: November 27, 2023

2023 journal article

Dietary phenolics and their microbial metabolites are poor inhibitors of trimethylamine oxidation to trimethylamine N-oxide by hepatic flavin monooxygenase 3

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 120.

By: L. Iglesias-Carres  n, S. Chadwick-Corbin n , M. Sweet n & A. Neilson n 

author keywords: Atherosclerosis; Cardiovascular disease; FMO3; Trimethylamine; Trimethylamine N-oxide
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2023 article

Gut Microbiota Depletion Using Antibiotics to Investigate Diet-Derived Microbial Metabolites: An Efficient Strategy

Babu, A. K. S., Petersen, C., Paz, H. A., Iglesias-Carres, L., Li, Y., Zhong, Y., … Babu, P. V. A. (2023, December 6). MOLECULAR NUTRITION & FOOD RESEARCH.

By: A. Babu*, C. Petersen*, H. Paz *, L. Iglesias-Carres  n, Y. Li *, Y. Zhong, A. Neilson n , U. Wankhade *, P. Babu *

author keywords: antibiotics; diet-derived microbial metabolites; gut microbes; metabolic health; trimethylamine; trimethylamine N-oxide
TL;DR: This strategy effectively depletes gut microbes and suppresses the production of microbial metabolites in mice without affecting their metabolic health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: December 18, 2023

2023 journal article

In vitro evidences of the globe artichoke antioxidant, cardioprotective and neuroprotective effects

JOURNAL OF FUNCTIONAL FOODS, 107.

By: L. Iglesias-Carres  n, A. Bruno*, I. 'Antuono *, V. Linsalata *, A. Cardinali * & A. Neilson n 

author keywords: Artichoke; Polyphenols; Antiaging; TMAO; Neuroprotective
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 28, 2023

2023 journal article

Mechanism of off-color formation in potato chips fried in oil systems containing ascorbic acid as a stabilizer

LWT-FOOD SCIENCE AND TECHNOLOGY, 179.

By: L. Iglesias-Carres  n, K. Racine n, S. Chadwick n, C. Nunn  n, S. Kalambur*, A. Neilson n , M. Ferruzzi*

author keywords: Amino acid; Maillard reaction; BHT; Rosemary; Carnosic acid; Tocopherol; Moisture; Solubility; Citric acid; Canola oil
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2022 article

Bioaccessibility and intestinal cell uptake of carotenoids and chlorophylls differ in powdered spinach by the ingredient form as measured using in vitro gastrointestinal digestion and anaerobic fecal fermentation models

Hayes, M., Mohamedshah, Z., Chadwick-Corbin, S., Hoskin, R., Iorizzo, M., Lila, M. A., … Ferruzzi, M. G. (2022, March 8). FOOD & FUNCTION, Vol. 13.

By: M. Hayes n, Z. Mohamedshah n, S. Chadwick-Corbin n , R. Hoskin  n, M. Iorizzo n, M. Lila n , A. Neilson n , M. Ferruzzi n

MeSH headings : Anaerobiosis; Caco-2 Cells; Carotenoids / metabolism; Chlorophyll; Digestion; Fermentation; Health Promotion; Humans; Powders; Spinacia oleracea / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 31, 2022

2022 article

Bioaccessibility, gut microbial metabolism and intestinal transport of phenolics from 100% Concord grape juice and whole grapes are similar in a simulated digestion and fecal fermentation model

Mohamedshah, Z., Hayes, M., Chadwick-Corbin, S., Neilson, A. P., & Ferruzzi, M. G. (2022, March 9). FOOD & FUNCTION, Vol. 3.

By: Z. Mohamedshah n, M. Hayes n, S. Chadwick-Corbin n , A. Neilson n  & M. Ferruzzi n

MeSH headings : Caco-2 Cells; Digestion; Fermentation; Fruit / chemistry; Gastrointestinal Microbiome; Humans; Phenols / analysis; Vitis / metabolism
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2022

2022 journal article

Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 626, 205–210.

By: K. Racine n, L. Iglesias-Carres  n, J. Herring, M. Ferruzzi n, C. Kay* , J. Tessem *, A. Neilson n 

author keywords: BTBR; Ob/ob; Type-2 diabetes; Flavanol; Insulin; Beta cell
MeSH headings : Animals; Cacao; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hyperglycemia; Hyperinsulinism; Male; Mice; Obesity; Pilot Projects; Plant Extracts / pharmacology; Plant Extracts / therapeutic use
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 17, 2022

2022 journal article

Effect of processing on the anti-inflammatory efficacy of cocoa in a high fat diet-induced mouse model of obesity

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 109.

By: D. Weikart *, V. Indukuri*, K. Racine n, K. Coleman*, J. Kovac *, D. Cockburn *, H. Hopfer *, A. Neilson n , J. Lambert*

author keywords: Cocoa; sex differences; roasting; fermentation; obesity; inflammation
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Anti-Inflammatory Agents / therapeutic use; Body Weight; Cacao; Chocolate; Diet, High-Fat / adverse effects; Disease Models, Animal; Food Ingredients; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Polyphenols / pharmacology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 11, 2022

2022 review

Enhancing the Cognitive Effects of Flavonoids With Physical Activity: Is There a Case for the Gut Microbiome?

[Review of ]. FRONTIERS IN NEUROSCIENCE, 16.

By: C. Cheatham*, D. Nieman*, A. Neilson n  & M. Lila n 

author keywords: age-related; cognition; neuroprotective; phenolic metabolites; prebiotic flavonoids; exercise; microbiome
TL;DR: There is a potential for combined impacts of flavonoids intake and physical exertion on cognitive function, as modulated by the gut microbiome, and that the combination of a flavonoid-rich diet and routine aerobic exercise may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the Gut microbiome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022

2022 journal article

Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 74(1), 194–210.

By: L. Griffin n, S. Kohrt *, A. Rathore n, C. Kay n , M. Grabowska * & A. Neilson n 

MeSH headings : Animals; Chromatography, Liquid; Gastrointestinal Microbiome; Polyphenols / analysis; Rats; Tandem Mass Spectrometry; Urinary Bladder Neoplasms / drug therapy
TL;DR: It is suggested that microbial metabolites may be the primary compounds responsible for chemoprevention in uroepithelial cell following flavanol consumption, highlighting the potential for exploiting knowledge about individual genetics, microbiome profiles, flavonoid metabolism profiles, tumor characteristics, etc. to design personalized dietary interventions for cancer prevention and/or adjuvant therapy to reduce bladder cancer incidence and improve outcomes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 10, 2021

2022 article

Phenolic-rich beverages reduce bacterial TMA formation in an ex vivo-in vitro colonic fermentation model

Iglesias-Carres, L., Racine, K. C., & Neilson, A. P. (2022, July 11). FOOD & FUNCTION.

By: L. Iglesias-Carres  n, K. Racine n & A. Neilson n 

MeSH headings : Atherosclerosis / metabolism; Bacteria / metabolism; Beverages; Chlorogenic Acid; Choline / metabolism; Coffee; Fermentation; Humans; Methylamines / metabolism
TL;DR: Regular cocoa and coffee consumption could be a nutritional strategy able to reduce TMAO levels, and fractionating digested bioactive beverages determined that those fractions rich in chlorogenic acid were the most bioactive. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: July 26, 2022

2022 journal article

Potential of Phenolic Compounds and Their Gut Microbiota-Derived Metabolites to Reduce TMA Formation: Application of an In Vitro Fermentation High-Throughput Screening Model

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(10), 3207–3218.

By: L. Iglesias-Carres  n, E. Krueger *, J. Herring, J. Tessem * & A. Neilson n 

author keywords: atherosclerosis; food bioactives; gut microbiota metabolites; phenolic compounds; TMA
MeSH headings : Choline / metabolism; Fermentation; Gastrointestinal Microbiome; High-Throughput Screening Assays; Humans; Methylamines
TL;DR: Overall, caffeic acid, catechin, and epicatechin were the most effective noncytotoxic inhibitors of choline use and TMA production, and these compounds are proposed as lead bioactives to test in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 18, 2022

2021 journal article

An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder

SCIENTIFIC REPORTS, 11(1).

By: M. Virdee*, N. Saini *, C. Kay n , A. Neilson n , S. Kwan *, K. Helfrich *, S. Mooney *, S. Smith *

MeSH headings : Animals; Disease Models, Animal; Female; Fetal Alcohol Spectrum Disorders / blood; Fetal Alcohol Spectrum Disorders / metabolism; Fetal Alcohol Spectrum Disorders / microbiology; Gastrointestinal Microbiome; Male; Mice; Mothers; Pregnancy
TL;DR: The maternal microbiome and its MDPs are a previously unrecognized influence upon the pathologies that typify PAE, and are concluded to constitute a characteristic biosignature that distinguishes PAE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 10, 2021

2021 journal article

Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 87.

By: L. Griffin n, L. Essenmacher*, K. Racine n, L. Iglesias-Carres  n, J. Tessem *, S. Smith *, A. Neilson n 

author keywords: Natural products; Genetic diversity; Diabetes; Flavonoids; Personalized nutrition; Interindividual variation
MeSH headings : Animals; Anti-Obesity Agents / therapeutic use; Collaborative Cross Mice / genetics; Collaborative Cross Mice / physiology; Diet, High-Fat / adverse effects; Disease Models, Animal; Female; Genetic Variation; Male; Obesity / drug therapy; Obesity / etiology; Obesity / genetics; Quercetin / therapeutic use; Sex Factors
TL;DR: How diverse mouse strains respond to diet-induced obesity when fed a representative flavonoid is explored to justify use of genetically diverse Collaborative Cross and Diversity Outbred models which are emerging as invaluable tools in the field of personalized nutrition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 11, 2021

2021 journal article

Fasting and postprandial trimethylamine N-oxide in sedentary and endurance-trained males following a short-term high-fat diet

PHYSIOLOGICAL REPORTS, 9(16).

By: C. Steele *, M. Baugh *, L. Griffin n, A. Neilson n , B. Davy *, M. Hulver*, K. Davy*

author keywords: endurance-trained; high-fat diet; sedentary; trimethylamine N-oxide
MeSH headings : Adolescent; Adult; Cardiometabolic Risk Factors; Diet, High-Fat / adverse effects; Dietary Fats / metabolism; Endurance Training; Fasting / metabolism; Humans; Male; Methylamines / blood; Postprandial Period; Sedentary Behavior
TL;DR: Plasma TMAO and TMA‐moiety concentrations were measured using isocratic ultraperformance liquid chromatography‐tandem mass spectrometry and VO2max was significantly higher in the endurance‐trained compared with sedentary males, and future studies are needed to identify the effects of endurance training on T MAO production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 7, 2021

2021 journal article

Gut Metabolite Trimethylamine N-Oxide Protects INS-1 beta-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions

BIOMOLECULES, 11(12).

By: E. Krueger *, J. Beales*, K. Russon*, W. Elison *, J. Davis*, J. Hansen *, A. Neilson n , J. Hansen *, J. Tessem *

author keywords: beta cell; islet; glucolipotoxicity (GLT); glucose stimulated insulin secretion (GSIS); unfolded protein response (UPR); type 2 diabetes (T2D)
MeSH headings : Animals; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Diabetes Mellitus, Type 2 / metabolism; Diabetes Mellitus, Type 2 / prevention & control; Endoplasmic Reticulum Stress; Endoribonucleases / metabolism; Female; Gastrointestinal Microbiome; Gene Expression Regulation / drug effects; Insulin / metabolism; Insulin-Secreting Cells / cytology; Insulin-Secreting Cells / drug effects; Insulin-Secreting Cells / metabolism; Methylamines / pharmacology; Models, Biological; Multienzyme Complexes / metabolism; Oxidative Stress; Primary Cell Culture; Protein Serine-Threonine Kinases / metabolism; Rats
TL;DR: Novel results demonstrate that TMAO protects β-cell function and suggest that T MAO may play a beneficial molecular role in diet-induced T2D conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 10, 2022

2021 journal article

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

HYPERTENSION, 78(2), 499–511.

By: V. Brunt *, A. Casso *, R. Gioscia-Ryan*, Z. Sapinsley*, B. Ziemba *, Z. Clayton *, A. Bazzoni*, N. VanDongen* ...

author keywords: advanced glycation end products; arterial stiffness; gut microbiota; pulse wave velocity
MeSH headings : Adolescent; Adult; Age Factors; Aged; Aging / blood; Animals; Aorta / drug effects; Aorta / physiology; Blood Pressure / drug effects; Blood Pressure / physiology; Female; Humans; Male; Methylamines / administration & dosage; Methylamines / blood; Mice; Middle Aged; Pulse Wave Analysis; Vascular Stiffness / drug effects; Vascular Stiffness / physiology; Young Adult
TL;DR: Ex vivo incubation of aortic rings with TMAO increased intrinsic stiffness, which was attenuated by the advanced glycation end-products crosslink breaker alagebrium and prevented by inhibition of superoxide signaling, which together increase intrinsic wall stiffness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 19, 2021

2021 article

Journal of Nutritional Biochemistry Special Issue: Polyphenols, obesity, and cardiometabolic health

Bruno, R. S., Neilson, A. P., Lambert, J. D., & Moustaid-Moussa, N. (2021, March). JOURNAL OF NUTRITIONAL BIOCHEMISTRY, Vol. 89.

By: R. Bruno *, A. Neilson n , J. Lambert * & N. Moustaid-Moussa *

MeSH headings : Cardiovascular Diseases / prevention & control; Gastrointestinal Microbiome / drug effects; Humans; Obesity / prevention & control; Obesity / therapy; Polyphenols / administration & dosage; Polyphenols / metabolism; Risk Factors; Tea / chemistry
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: April 12, 2021

2021 journal article

Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial

NUTRIENTS, 13(9).

By: C. Mitchell *, B. Davy *, M. Ponder *, R. McMillan *, M. Hughes *, M. Hulver*, A. Neilson n , K. Davy*

author keywords: dietary fiber; prebiotics; inulin; diabetes; metabolism; gut microbiota
MeSH headings : Diabetes Mellitus, Type 2 / prevention & control; Dietary Supplements; Female; Humans; Insulin / blood; Insulin Resistance; Inulin / administration & dosage; Inulin / pharmacology; Male; Middle Aged; Pilot Projects; Prebiotics
TL;DR: Despite increases in gut Bifidobacteria, inulin supplementation did not improve peripheral insulin sensitivity, and these findings question the need for larger investigations of inulin and insulin sensitivity in this population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 12, 2021

2021 journal article

Techno-economic analysis of a grape pomace biorefinery: Production of seed oil, polyphenols, and biochar

FOOD AND BIOPRODUCTS PROCESSING, 127, 139–151.

By: Q. Jin *, . Sean F. O'Keefe *, A. Stewart *, A. Neilson n , Y. Kim * & H. Huang *

author keywords: Techno-economic analysis; Grape pomace; Seed oil; Polyphenol; Biochar
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 10, 2021

2021 journal article

The gut microbiome-derived metabolite trimethylamineN-oxide modulates neuroinflammation and cognitive function with aging

GEROSCIENCE, 43(1), 377–394.

By: V. Brunt *, T. LaRocca *, A. Bazzoni*, Z. Sapinsley*, J. Miyamoto-Ditmon*, R. Gioscia-Ryan*, A. Neilson* , C. Link*, D. Seals *

author keywords: Cognitive impairment; Inflammation; Astrocyte activation; Brain; Memory
MeSH headings : Aging; Animals; Cognition; Gastrointestinal Microbiome; Methylamines; Mice
TL;DR: The results provide translational insight into a novel pathway that modulates neuro inflammation and cognitive function with aging, and suggest that TMAO might be a promising target for prevention of neuroinflammation and cognitive decline with aging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 14, 2020

2021 journal article

Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 91.

By: L. Iglesias-Carres  n, M. Hughes *, C. Steele *, M. Ponder *, K. Davy* & A. Neilson n 

author keywords: Atherosclerosis; Cardiovasculardisease; Phytochemicals; TMAO
MeSH headings : Animals; Atherosclerosis / metabolism; Atherosclerosis / therapy; Cardiovascular Diseases / metabolism; Cardiovascular Diseases / therapy; Drug Discovery; Gastrointestinal Microbiome / drug effects; Humans; Lipid Metabolism / drug effects; Methylamines / antagonists & inhibitors; Methylamines / metabolism; Oxidative Stress / drug effects; Phytochemicals / pharmacology
TL;DR: The information provided by this review outlines the current state of the art of the role of phytochemicals as TMAO reducing agents, providing valuable insight to further advance in this field of study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 26, 2021

2021 article

Utilizing preclinical models of genetic diversity to improve translation of phytochemical activities from rodents to humans and inform personalized nutrition

Iglesias-Carres, L., & Neilson, A. P. (2021, October 14). FOOD & FUNCTION.

By: L. Iglesias-Carres  n & A. Neilson n 

MeSH headings : Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Genetic Variation / genetics; Humans; Mice; Mice, Inbred Strains / genetics; Nutritional Physiological Phenomena / drug effects; Nutritional Physiological Phenomena / genetics; Phytochemicals / administration & dosage; Phytochemicals / pharmacology; Translational Research, Biomedical
TL;DR: This review will focus on the current work performed with genetically diverse mouse populations, and the research opportunities and advantages that these models can offer to phytochemical research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: November 8, 2021

2020 journal article

Flavone Hispidulin Stimulates Glucagon-Like Peptide-1 Secretion and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

MOLECULAR NUTRITION & FOOD RESEARCH, 64(6).

By: Y. Wang *, A. Wang *, H. Alkhalidy *, J. Luo *, E. Moomaw*, A. Neilson n , D. Liu *

author keywords: diabetes; glucagon-like peptide-1; hispidulin; insulin; mice
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Cyclic AMP / metabolism; Cyclic AMP-Dependent Protein Kinases / metabolism; Diabetes Mellitus, Experimental / drug therapy; Diabetes Mellitus, Experimental / metabolism; Eating / drug effects; Flavones / pharmacology; Glucagon-Like Peptide 1 / metabolism; Hyperglycemia / drug therapy; Hyperglycemia / metabolism; Hypoglycemic Agents / pharmacology; Insulin / metabolism; Insulin-Secreting Cells / drug effects; Insulin-Secreting Cells / metabolism; Male; Mice, Inbred C57BL
TL;DR: Hispidulin significantly improved glycemic control in diabetic mice, concomitant with improved insulin release and β-cell survival, and suggest that hispidulin may be a novel dual-action anti-diabetic compound via stimulating GLP-1 secretion and suppressing hepatic glucose production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 17, 2020

2020 journal article

Grape pomace and its secondary waste management: Biochar production for a broad range of lead (Pb) removal from water

ENVIRONMENTAL RESEARCH, 186.

By: Q. Jin *, Z. Wang *, Y. Feng *, Y. Kim *, A. Stewart *, . Sean F. O'Keefe *, A. Neilson n , Z. He *, H. Huang *

author keywords: Grape pomace; Biochar; Pb; Adsorption mechanism; Water contamination
MeSH headings : Adsorption; Charcoal; Lead; Vitis; Wastewater; Water
TL;DR: To approach zero solid waste during GP processing, a pyrolysis process was designed for converting GP and its secondary processing wastes to biochars, which were then evaluated for lead (Pb) adsorption from water. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 3, 2020

2020 journal article

Modulating Phenolic Bioaccessibility and Glycemic Response of Starch-Based Foods in Wistar Rats by Physical Complexation between Starch and Phenolic Acid

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 68(46), 13257–13266.

By: M. Li n, L. Griffin n, S. Corbin n, A. Neilson n  & M. Ferruzzi n

author keywords: LC-MS; in vitro bioaccessibility; cellular uptake efficiency; postprandial glycemic response; Caco-2 human intestinal cells; starch-phenolic complexes
MeSH headings : Animals; Blood Glucose / metabolism; Caco-2 Cells; Glycemic Index; Humans; Hydroxybenzoates / metabolism; Intestines; Male; Phenols / metabolism; Rats; Rats, Wistar; Solanum tuberosum / metabolism; Starch / analysis; Starch / metabolism; Zea mays / metabolism
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Postprandial skeletal muscle metabolism following a high-fat diet in sedentary and endurance-trained males

JOURNAL OF APPLIED PHYSIOLOGY, 128(4), 872–883.

By: M. Baugh *, S. Bowser*, R. McMillan *, B. Davy *, L. Essenmacher*, A. Neilson n , M. Hulver*, K. Davy*

author keywords: exercise; high-fat diet; metabolic flexibility; skeletal muscle; substrate oxidation
MeSH headings : Diet, High-Fat; Endurance Training; Fasting; Humans; Male; Muscle, Skeletal; Postprandial Period
TL;DR: Insight is provided into differing substrate metabolism responses between SED and ET individuals and the role the prevailing diet may play in modulating fasting and postprandial metabolic responses in skeletal muscle is highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 18, 2020

2020 journal article

Preference for and sensitivity to flavanol mean degree of polymerization in model wines is correlated with body composition

APPETITE, 144.

By: L. Griffin n, C. Diako *, L. Miller*, A. Neilson n , C. Ross * & A. Stewart* 

author keywords: Astringency; Preference; BMI; Body fat percentage; PROP
MeSH headings : Adipose Tissue; Adult; Body Composition / physiology; Body Mass Index; Body Weight / physiology; Female; Food Preferences / drug effects; Food Preferences / physiology; Humans; Male; Middle Aged; Polymerization; Polyphenols / administration & dosage; Propylthiouracil / administration & dosage; Taste / drug effects; Taste / physiology; Taste Buds / drug effects; Taste Threshold / drug effects; Wine / analysis; Young Adult
TL;DR: The data suggest that weight status in adults is a greater predictor of liking of flavanol-rich foods than bitterness sensitivity (as determined by PROP classification), and that reduced perception of bitterness and astringency associated with weight gain may impact selection and preference for these foods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: December 9, 2019

2020 journal article

Serum endotoxin, gut permeability and skeletal muscle metabolic adaptations following a short term high fat diet in humans

METABOLISM-CLINICAL AND EXPERIMENTAL, 103.

By: S. Bowser*, R. McMillan *, N. Boutagy *, M. Tarpey*, A. Smithson*, K. Osterberg*, A. Neilson* , B. Davy *, K. Davy*, M. Hulver*

author keywords: Skeletal muscle; Substrate oxidation; Metabolic flexibility; High fat diet; Metabolic adaptation
MeSH headings : Adaptation, Physiological / physiology; Adult; Diet, High-Fat; Dietary Fats / pharmacology; Endotoxins / blood; Energy Metabolism / drug effects; Humans; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestines / drug effects; Intestines / pathology; Lipid Metabolism / drug effects; Male; Muscle, Skeletal / drug effects; Muscle, Skeletal / metabolism; Muscle, Skeletal / pathology; Permeability; Young Adult
TL;DR: It is demonstrated that in healthy young men, consuming an isocaloric HFD for 5 days increases fasting endotoxin, independent of changes in gut permeability, and these changes in endotoxin are accompanied by a broad effect on skeletal muscle substrate metabolism including increases in postprandial fat oxidation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 27, 2020

2020 article

Supplemental treatment options for diabetes: how flavanol metabolites improve beta-cell function

Lloyd, T., Griffin, L., Krueger, E., Beales, J., Barlow, A., Sheets, J., … Tessem, J. (2020, April). FASEB JOURNAL, Vol. 34.

By: T. Lloyd*, L. Griffin n, E. Krueger *, J. Beales*, A. Barlow*, J. Sheets*, I. Ekpo*, M. Ross* ...

TL;DR: Data is presented regarding the in vitro effects of these absorbed gut bacteria derived flavanoids on INS‐1 832/13 β‐cell insulin secretion and proliferation and further light is shed on the potential ability of flavanoid and their gut bacteriaderived metabolites to enhance functional β‐ cell mass. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 journal article

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

HYPERTENSION, 76(1), 101–112.

By: V. Brunt *, R. Gioscia-Ryan*, A. Casso *, N. VanDongen*, B. Ziemba *, Z. Sapinsley*, J. Richey*, M. Zigler* ...

author keywords: acetylcholine; aging; brachial artery; microbiota nitric oxide; superoxide
MeSH headings : Acetylcholine / pharmacology; Adolescent; Adult; Aged; Aging / blood; Aging / physiology; Animals; Antioxidants / pharmacology; Ascorbic Acid / pharmacology; Brachial Artery / drug effects; Brachial Artery / physiology; Carotid Arteries / drug effects; Carotid Arteries / physiology; Cyclic N-Oxides / pharmacology; Dietary Supplements; Endothelium, Vascular / drug effects; Gastrointestinal Microbiome; Humans; Methylamines / administration & dosage; Methylamines / blood; Methylamines / toxicity; Mice; Mice, Inbred C57BL; Middle Aged; Nitric Oxide / blood; Nitric Oxide Synthase Type III / metabolism; Oxidative Stress / drug effects; Spin Labels; Superoxides / metabolism; Tyrosine / analogs & derivatives; Tyrosine / blood; Vasodilation / drug effects; Vasodilation / physiology; Young Adult
TL;DR: A clear role of trimethylamine-N-oxide is demonstrated in promoting age-related endothelial dysfunction via oxidative stress through oxidative stress in middle-aged/older adults, which may have implications for prevention of cardiovascular diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 27, 2020

2019 journal article

A Mediterranean diet does not alter plasma trimethylamine N-oxide concentrations in healthy adults at risk for colon cancer

FOOD & FUNCTION, 10(4), 2138–2147.

By: L. Griffin*, Z. Djuric *, C. Angiletta*, C. Mitchell *, M. Baugh *, K. Davy*, A. Neilson* 

MeSH headings : Adult; Aged; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Bacteria / metabolism; Betaine / blood; Choline / blood; Colonic Neoplasms / blood; Colonic Neoplasms / diet therapy; Colonic Neoplasms / metabolism; Colonic Neoplasms / microbiology; Diet, Mediterranean; Fasting; Female; Gastrointestinal Microbiome; Humans; Male; Methylamines / blood; Middle Aged
TL;DR: It is suggested that broad dietary pattern intervention over six months may not be sufficient for reducing TMAO concentrations in an otherwise healthy population, and disruption of the conversion of dietary TMA to T MAO should be the focus of future studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: April 20, 2020

2019 journal article

Comparison of Common Analytical Methods for the Quantification of Total Polyphenols and Flavanols in Fruit Juices and Ciders

JOURNAL OF FOOD SCIENCE, 84(8), 2147–2158.

By: S. Ma *, C. Kim*, A. Neilson* , L. Griffin*, G. Peck *, . Sean F. O'Keefe *, A. Stewart* 

author keywords: BSA precipitation; DMAC; flavanols; Folin-Ciocalteu; Lowenthal permanganate titration
MeSH headings : Flavanones / analysis; Food Analysis / methods; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Malus / chemistry; Polyphenols / analysis
TL;DR: Results obtained can help manufacturers of fruit‐based products choose the most appropriate analytical method for polyphenol quantification as part of a quality assurance program or to convey information on dietarypolyphenol content to consumers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019

2019 journal article

Compositional Characterization of Different Industrial White and Red Grape Pomaces in Virginia and the Potential Valorization of the Major Components

FOODS, 8(12).

By: Q. Jin *, J. O'Hair*, A. Stewart *, . Sean F. O'Keefe *, A. Neilson n , Y. Kim *, M. McGuire, A. Lee *, G. Wilder*, H. Huang *

author keywords: grape pomace; chemical composition; fatty acids; polyphenols; carbohydrates; lignin
TL;DR: Considering the valuable extractives and non-extractives of grape pomace and lignin, designing a biorefinery process aiming at fully recover and/or utilize these components is of future significance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 27, 2020

2019 journal article

Development of a rapid ultra performance hydrophilic interaction liquid chromatography tandem mass spectrometry method for procyanidins with enhanced ionization efficiency

JOURNAL OF CHROMATOGRAPHY A, 1594, 54–64.

By: K. Racine*, A. Lee *, A. Stewart *, K. Blakeslee* & A. Neilson n 

author keywords: Cocoa; Sensitivity; Electrospray ionization; Diol; Ammonium formate
MeSH headings : Biflavonoids / analysis; Biflavonoids / isolation & purification; Catechin / analysis; Catechin / isolation & purification; Chemistry Techniques, Analytical / methods; Chromatography, Liquid; Formates / chemistry; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Proanthocyanidins / analysis; Proanthocyanidins / isolation & purification; Tandem Mass Spectrometry
TL;DR: This method builds upon the foundation set by existing analytical methods and employs new technologies to dramatically increase sample throughput and enhance detection limits and specificity, facilitating improved analysis for procyanidins. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 28, 2019

2019 journal article

Flavanol Polymerization Is a Superior Predictor of alpha-Glucosidase Inhibitory Activity Compared to Flavanol or Total Polyphenol Concentrations in Cocoas Prepared by Variations in Controlled Fermentation and Roasting of the Same Raw Cocoa Beans

ANTIOXIDANTS, 8(12).

By: K. Racine*, B. Wiersema*, L. Griffin n, L. Essenmacher*, A. Lee *, H. Hopfer *, J. Lambert *, A. Stewart *, A. Neilson n 

author keywords: flavan-3-ol; procyanidin; alpha-glucosidase; melanoidin; Maillard reaction
TL;DR: It is demonstrated that cocoa powders are potent inhibitors of α-glucosidase, and non-traditional compositional markers may be better predictors of enzyme inhibitory activity than cocoa native flavanols. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 27, 2020

2019 journal article

Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet

NUTRITION RESEARCH, 66, 32–47.

By: L. Griffin*, D. Fausnacht *, J. Tuzo*, A. Addington*, K. Racine*, H. Zhang *, M. Hughes *, K. England* ...

author keywords: Mean degree of polymerization (mDP); Flavanols; Procyanidins (PCs); Glucose intolerance; Cytokines
MeSH headings : Adipose Tissue / chemistry; Animals; Body Composition / drug effects; Diet, High-Fat / adverse effects; Dietary Supplements; Eating / drug effects; Flavonols / administration & dosage; Glucose Intolerance / prevention & control; Grape Seed Extract / chemistry; Inflammation / prevention & control; Insulin Resistance; Interleukin-6 / analysis; Male; Mice; Mice, Inbred C57BL; Obesity / physiopathology; Pinus / chemistry; Plant Bark / chemistry; Weight Gain / drug effects
TL;DR: Overall, low-dose flavanol extract supplementation, regardless of mean degrees of polymerization, blunted cytokine production despite increased weight gain, suggesting flavanols may be used as complementary interventions to ameliorate increased inflammatory tone in the contexts of obesity and diabetes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 22, 2019

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