Works (96)

Updated: July 29th, 2023 21:15

2021 journal article

Epistasis for head morphology in Drosophila melanogaster

G3-GENES GENOMES GENETICS, 11(10).

By: E. Ozsoy*, M. Yilmaz*, B. Patlar*, G. Emecen*, E. Durmaz*, M. Magwire*, S. Zhou*, W. Huang*, R. Anholt n, T. Mackay n

author keywords: Drosophila Genetic Reference Panel; genome-wide association analyses; modifier loci; genetic interaction network
MeSH headings : Alleles; Animals; Chromosome Mapping; Drosophila melanogaster / genetics; Epistasis, Genetic; Genome-Wide Association Study
TL;DR: The Drosophila melanogaster Genetic Reference Panel of sequenced inbred lines is used to evaluate the magnitude of naturally occurring epistasis modifying the effects of mutations in jing and inv, two transcription factors that have subtle quantitative effects on head morphology as homozygotes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: January 10, 2022

2021 journal article

Functional Diversification, Redundancy, and Epistasis among Paralogs of the Drosophila melanogaster Obp50a-d Gene Cluster

MOLECULAR BIOLOGY AND EVOLUTION, 38(5), 2030–2044.

By: J. Johnstun n, V. Shankar*, S. Mokashi n, L. Sunkara*, U. Ihearahu*, R. Lyman*, T. Mackay n, R. Anholt n

author keywords: multigene families; functional diversification; transcriptional niche; RNAseq; odorant-binding proteins; evolutionary genetics
MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Epistasis, Genetic; Evolution, Molecular; Fat Body / metabolism; Female; Genitalia, Male / metabolism; Male; Multigene Family; Phenotype; Pupa / metabolism; Receptors, Odorant / genetics; Receptors, Odorant / metabolism
TL;DR: There is functional diversification within the Obp50 cluster with Ob p50a contributing to development and Obp 50d to stress resistance, and the deletion–reinsertion approach applied provides a general paradigm for the genetic dissection of paralogs of multigene families. (via Semantic Scholar)
Source: Web Of Science
Added: June 10, 2021

2021 journal article

Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(23).

By: B. Baker*, M. Carbone n, W. Huang*, R. Anholt* & T. Mackay*

author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
TL;DR: It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021

2020 journal article

Context-dependent genetic architecture of Drosophila life span

PLOS BIOLOGY, 18(3).

By: W. Huang n, T. Campbell n, M. Carbone n, W. Jones n, D. Unselt n, R. Anholt n, T. Mackay n

MeSH headings : Animals; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene-Environment Interaction; Genetic Variation; Genome-Wide Association Study; Longevity / genetics; Male; RNA Interference; Temperature
TL;DR: The results implicate novel candidate genes affecting life span and suggest that variation for life span may be maintained by variable allelic effects in heterogeneous environments. (via Semantic Scholar)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Gene expression networks in the Drosophila Genetic Reference Panel

GENOME RESEARCH, 30(3), 485–496.

By: L. Everett n, W. Huang n, S. Zhou n, M. Carbone n, R. Lyman n, G. Arya n, M. Geisz n, J. Ma* ...

MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Drosophila melanogaster / microbiology; Female; Gene Expression Regulation; Gene Regulatory Networks; Genetic Variation; High-Throughput Nucleotide Sequencing; Male; Microbiota / genetics; Quantitative Trait Loci; Sequence Analysis, RNA
TL;DR: This study performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions, transposable elements and microbial species, providing new insights regarding the role of natural genetic variation in regulating gene expression. (via Semantic Scholar)
Source: Web Of Science
Added: April 14, 2020

2020 journal article

Genotype by environment interaction for gene expression in Drosophila melanogaster

NATURE COMMUNICATIONS, 11(1).

By: W. Huang n, M. Carbone n, R. Lyman n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Expression; Gene Expression Regulation; Gene Regulatory Networks; Gene-Environment Interaction; Genes, Insect; Genetic Variation; Genotype; Male; Quantitative Trait Loci; RNA-Seq; Temperature; Transcriptome
TL;DR: It is shown that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co- expression network remains robust, and data suggest that stabilizing selection on gene expression may promote co-expression network robustness. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 30, 2020

2020 journal article

Systems genetics of the Drosophila metabolome

GENOME RESEARCH, 30(3), 392–405.

By: S. Zhou n, F. Morgante n, M. Geisz n, J. Ma*, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Female; Genetic Association Studies; Genetic Variation; Male; Metabolome / genetics; Phenotype; Quantitative Trait Loci
TL;DR: This work identified sex-specific modules of genetically correlated metabolites and constructed networks that integrate DNA sequence variation and variation in gene expression with variation in metabolites and organismal traits, including starvation stress resistance and male aggression. (via Semantic Scholar)
Source: Web Of Science
Added: April 14, 2020

2019 journal article

Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster

PLOS GENETICS, 15(5).

By: C. Highfill n, B. Baker n, S. Stevens n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Central Nervous System Stimulants / metabolism; Cocaine / metabolism; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins / genetics; Dopamine Plasma Membrane Transport Proteins / metabolism; Dopaminergic Neurons / metabolism; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Feeding Behavior; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome, Insect; Male; Methamphetamine / metabolism; Mushroom Bodies / metabolism; Mushroom Bodies / physiopathology; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Sex Characteristics; Substance-Related Disorders / genetics; Substance-Related Disorders / metabolism; Substance-Related Disorders / physiopathology
Source: Web Of Science
Added: June 24, 2019

2018 journal article

The road less traveled: from genotype to phenotype in flies and humans

Mammalian Genome, 29(1-2), 5–23.

By: R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Female; Gene Regulatory Networks; Genome, Human / genetics; Genome, Insect / genetics; Genome-Wide Association Study; Genotype; Humans; Linkage Disequilibrium; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics
TL;DR: The D. melanogaster Genetic Reference Panel (DGRP) has enabled genome-wide association studies of morphological, physiological, behavioral, and life history traits, and demonstrated that genetic architectures of complex traits are highly polygenic, sexually dimorphic, and context dependent with extensive sex-, environment-, and genetic background (epistatic) effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Crossref
Added: November 28, 2020

2017 journal article

Regulation of Drosophila Lifespan by bellwether Promoter Alleles

Scientific Reports, 7(1).

By: J. Garcia n, M. Carbone n, T. Mackay n & R. Anholt n

MeSH headings : Alleles; Animals; Drosophila / physiology; Female; Gene Expression Regulation; Gene Knockdown Techniques; Longevity / genetics; Male; Mitochondrial Proton-Translocating ATPases / chemistry; Mitochondrial Proton-Translocating ATPases / genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein Subunits / genetics; RNA Interference
TL;DR: Results show that naturally occurring regulatory variants of blw affect lifespan in a sex-specific manner. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2016 journal article

Genetic architecture of natural variation in visual senescence in Drosophila

Proceedings of the National Academy of Sciences, 113(43), E6620–E6629.

By: M. Carbone n, A. Yamamoto n, W. Huang n, R. Lyman n, T. Meadors n, R. Yamamoto n, R. Anholt n, T. Mackay n

author keywords: aging; behavioral genetics; DGRP GWA analysis; phototaxis; xQTL mapping
MeSH headings : Aging / genetics; Animals; Biological Variation, Individual; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / metabolism; Eye Proteins / genetics; Eye Proteins / metabolism; Gene Expression Regulation, Developmental; Gene Regulatory Networks; Genetic Variation; Genome; Genome-Wide Association Study; Humans; Phototaxis; Quantitative Trait Loci; Vision, Ocular / genetics
TL;DR: It is found the genetic basis for visual senescence is distinct from that which determines variation in life span, and genes shaping early development of the nervous system, in particular the visual system, also contribute toSenescence at later age, demonstrating that senescences is part of a genetic continuum throughout the life span. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2015 journal article

Dissecting the genetic architecture of behavior in Drosophila melanogaster

Current Opinion in Behavioral Sciences, 2, 1–7.

By: R. Anholt n & T. Mackay n

TL;DR: Drosophila melanogaster presents a powerful system for dissecting the genetic basis of behavioral phenotypes, since both the genetic background and environmental conditions can be controlled and behaviors accurately quantified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science; OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Drosophotoxicolgy takes flight: Genomic elucidation of adverse outcome pathways of mercury toxicity in the fruit fly

Toxicology Letters, 238(2), S55.

By: M. Rand*, S. Montgomery*, D. Vorojeikina*, W. Huang n, T. MacKay n & R. Anholt n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Genetic architecture of natural variation in Drosophila melanogaster aggressive behavior

Proceedings of the National Academy of Sciences, 112(27), E3555–E3563.

By: J. Shorter n, C. Couch n, W. Huang n, M. Carbone n, J. Peiffer n, R. Anholt n, T. Mackay n

author keywords: Drosophila Genetic Reference Panel; genome-wide association mapping; extreme QTL mapping; advanced intercross population; epistasis
MeSH headings : Aggression; Animals; Crosses, Genetic; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / classification; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Evolution, Molecular; Genes, Insect / genetics; Genes, Insect / physiology; Genetic Variation; Genome, Insect / genetics; Humans; Inbreeding; Mutation; RNA Interference; Species Specificity
TL;DR: This work performed genome-wide association analyses using the inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel and an advanced intercross population derived from the most and least aggressive DGRP lines to identify genes that have been previously implicated in aggressive behavior as well as many novel loci. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Crossref
Added: February 24, 2020

2015 journal article

Genetic basis of transcriptome diversity in Drosophila melanogaster

Proceedings of the National Academy of Sciences, 112(44), E6010–E6019.

By: W. Huang n, M. Carbone n, M. Magwire n, J. Peiffer n, R. Lyman n, E. Stone n, R. Anholt n, T. Mackay n

author keywords: genome-wide association; novel transcribed regions; mean eQTLs; variance eQTLs; epistasis
MeSH headings : Animals; Drosophila melanogaster / genetics; Epistasis, Genetic; Quantitative Trait Loci; Transcriptome
TL;DR: High complexity of the genetic control of gene expression is found, including widespread sexual dimorphism, highly modularized expression patterns with involvement of novel RNA transcripts, and frequent epistatic interactions among expression quantitative trait loci (QTLs) which often give rise to variance expression QTLs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2015 journal article

Identification of conserved developmental pathways targeted by methylmercury in Drosophila melanogaster

Neurotoxicology and Teratology, 49, 141.

By: M. Rand*, S. Montgomery*, D. Vorojeikina*, W. Huang n, T. MacKay n & R. Anholt n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2014 journal article

Genetics and genomics of alcohol sensitivity

Molecular Genetics and Genomics, 289(3), 253–269.

By: T. Morozova n, T. Mackay n & R. Anholt n

author keywords: Addiction; Behavioral genetics; Genome-wide association; Quantitative trait loci; Meta-analysis
MeSH headings : Alcoholism / genetics; Alcoholism / metabolism; Animals; Epigenesis, Genetic; Ethanol / metabolism; Gene Expression Regulation; Genetic Predisposition to Disease; Genomics; Humans; Phenotype
TL;DR: This review summarizes insights from model organisms as well as human populations that represent the current understanding of the genetic and genomic underpinnings that govern alcohol metabolism and the sedative and addictive effects of alcohol on the nervous system. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2014 journal article

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Genome Research, 24(7), 1193–1208.

By: W. Huang, A. Massouras, Y. Inoue, J. Peiffer, M. Ramia, A. Tarone, L. Turlapati, T. Zichner ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Transcriptional and epigenetic responses to mating and aging in Drosophila melanogaster

BMC GENOMICS, 15.

By: S. Zhou n, T. Mackay n & R. Anholt n

author keywords: microRNA; Histone modification; ChipSeq; Environmental plasticity; Systems genetics
MeSH headings : Aging / genetics; Animals; Behavior, Animal; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Regulatory Networks; Histones / metabolism; Male; MicroRNAs / genetics; Oviposition / genetics; Phenotype; Reproduction / genetics; Transcription, Genetic / physiology
TL;DR: The results implicate microRNAs as mediators of phenotypic plasticity associated with mating and provide a comprehensive documentation of the genomic and epigenomic changes that accompany mating- and aging-induced physiological changes in female D. melanogaster. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2013 review

A molecular mechanism for glaucoma: endoplasmic reticulum stress and the unfolded protein response

[Review of ]. TRENDS IN MOLECULAR MEDICINE, 19(10), 586–593.

By: R. Anholt n & M. Carbone n

author keywords: primary open angle glaucoma; ocular hypertension; myocilin; neurodegenerative disease
MeSH headings : Animals; Cytoskeletal Proteins / metabolism; Endoplasmic Reticulum Stress; Eye Proteins / metabolism; Glaucoma / pathology; Glycoproteins / metabolism; Humans; Neurodegenerative Diseases / pathology; Translational Research, Biomedical; Unfolded Protein Response
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior

Proceedings of the National Academy of Sciences, 110(3), 1017–1022.

author keywords: genetic architecture; chemosensation; behavioral genetics
MeSH headings : Animals; Behavior, Animal / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Gene Regulatory Networks; Genes, Insect; Genetic Association Studies; Genetic Variation; Genetics, Behavioral; Genome-Wide Association Study; Humans; Male; Models, Genetic; Models, Neurological; Neurogenesis / genetics; Neurogenesis / physiology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Smell / genetics; Smell / physiology
TL;DR: The results suggest that fully understanding the genotype–phenotype relationship requires a paradigm shift from a focus on single SNPs to pathway associations, and the lack of replication between the GWA analyses, small marginal SNP effects, and convergence on common cellular networks were likely attributable to epistasis. (via Semantic Scholar)
Source: Crossref
Added: January 5, 2021

2012 journal article

Epistasis dominates the genetic architecture of Drosophila quantitative traits

Proceedings of the National Academy of Sciences, 109(39), 15553–15559.

By: W. Huang, S. Richards*, M. Carbone*, D. Zhu*, R. Anholt n, J. Ayroles, L. Duncan, K. Jordan ...

author keywords: chill coma recovery; genetic interaction networks; genome-wide association studies; startle response; starvation resistance
MeSH headings : Animals; Drosophila melanogaster; Epistasis, Genetic / physiology; Genes, Insect / physiology; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
TL;DR: The analysis underscores the importance of epistasis as a principal factor that determines variation for quantitative traits and provides a means to uncover genetic networks affecting these traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2012 journal article

Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster

Genetics Research, 94(1), 9–20.

By: S. Swarup n, S. Harbison n, L. Hahn n, T. Morozova n, A. Yamamoto n, T. Mackay n, R. Anholt n

MeSH headings : Animals; Benzaldehydes; Calreticulin / genetics; Calreticulin / physiology; Chromosomes, Insect; DNA Transposable Elements; Drosophila Proteins / genetics; Drosophila Proteins / physiology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Female; Genes, Insect; Genetic Pleiotropy; Male; Membrane Glycoproteins / genetics; Membrane Glycoproteins / physiology; Mutagenesis, Insertional; Mutation; Odorants; Phenotype; Quantitative Trait, Heritable; Reflex, Startle / genetics; Semaphorins / genetics; Semaphorins / physiology; Sleep / genetics; Smell / genetics; Wakefulness / genetics
Source: Crossref
Added: August 28, 2020

2012 journal article

Phenotypic Plasticity of the Drosophila Transcriptome

PLOS GENETICS, 8(3).

By: S. Zhou n, T. Campbell n, E. Stone n, T. Mackay n & R. Anholt n

MeSH headings : Animals; Cluster Analysis; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Expression Regulation; Gene-Environment Interaction; Genetic Fitness; Genome, Insect; Phenotype; Transcriptome
TL;DR: This analysis suggests that a restricted environmentally responsive segment of the transcriptome preserves the balance between phenotypic plasticity and environmental canalization. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

The Drosophila melanogaster Genetic Reference Panel

Nature, 482(7384), 173–178.

By: T. Mackay n, S. Richards*, E. Stone n, A. Barbadilla*, J. Ayroles n, D. Zhu*, S. Casillas*, Y. Han* ...

MeSH headings : Alleles; Animals; Centromere / genetics; Chromosomes, Insect / genetics; Drosophila melanogaster / genetics; Genome-Wide Association Study; Genomics; Genotype; Phenotype; Polymorphism, Single Nucleotide / genetics; Quantitative Trait Loci / genetics; Selection, Genetic / genetics; Starvation / genetics; Telomere / genetics; X Chromosome / genetics
TL;DR: The Drosophila melanogaster Genetic Reference Panel is described, a community resource for analysis of population genomics and quantitative traits, which reveals reduced polymorphism in centromeric autosomal regions and the X chromosomes, evidence for positive and negative selection, and rapid evolution of the X chromosome. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2012 journal article

The genetic basis for natural variation in alcohol sensitivity in drosophila

Neurotoxicology and Teratology, 34(3), 377.

By: T. Morozova, S. Sridhar, M. Magwire, T. Mackay & R. Anholt*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2011 journal article

Complex genetic architecture of Drosophila aggressive behavior

Proceedings of the National Academy of Sciences, 108(41), 17070–17075.

By: L. Zwarts*, M. Magwire*, M. Carbone*, M. Versteven*, L. Herteleer*, R. Anholt n, P. Callaerts*, T. Mackay*

MeSH headings : Aggression / physiology; Animals; Behavior, Animal / physiology; Brain / anatomy & histology; Crosses, Genetic; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Evolution, Molecular; Female; Gene Expression; Gene Regulatory Networks; Genes, Insect; Male; Mutation; Phenotype
TL;DR: The transcriptional signatures of homozygous and double heterozygous genotypes derived from the six mutations imply a large mutational target for aggressive behavior and point to evolutionarily conserved genetic mechanisms and neural signaling pathways affecting this universal fitness trait. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Crossref
Added: February 24, 2020

2011 journal article

Functional dissection of Odorant binding protein genes in Drosophila melanogaster

GENES BRAIN AND BEHAVIOR, 10(6), 648–657.

Contributors: S. Swarup*, T. Williams* & R. Anholt n

author keywords: Behavioral genetics; chemoreception; olfaction; proteomics; RNAi
MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Gene Expression; Proteomics; Receptors, Odorant / genetics; Smell / genetics
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Genes of the Unfolded Protein Response Pathway Harbor Risk Alleles for Primary Open Angle Glaucoma

PLOS ONE, 6(5).

By: M. Carbone n, Y. Chen*, G. Hughes*, R. Weinreb*, N. Zabriskie*, K. Zhang*, R. Anholt n

MeSH headings : Aged; Alleles; Female; Genotype; Glaucoma, Open-Angle / genetics; Haplotypes / genetics; Humans; Inhibitor of Apoptosis Proteins / genetics; Linkage Disequilibrium / genetics; Male; Polymorphism, Single Nucleotide / genetics; Protein Disulfide-Isomerases / genetics; Signal Transduction / genetics; Signal Transduction / physiology; Unfolded Protein Response / genetics; Unfolded Protein Response / physiology
TL;DR: Combating genomics approach demonstrates that effectiveness of the UPR in response to accumulation of misfolded or aggregated proteins may contribute to the pathogenesis of POAG and provide targets for early therapeutic intervention. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Making scents of behavioural genetics: lessons from Drosophila

GENETICS RESEARCH, 92(5-6), 349–359.

By: R. Anholt n

MeSH headings : Animals; Behavior, Animal; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Regulatory Networks; Genetic Linkage; Genetics, Behavioral; Humans; Olfactory Perception
TL;DR: This review focuses on olfactory behaviour in Drosophila with the goal to illustrate how fundamental insights derived from studies on chemosensation can be applied to a wide range of behavioural phenotypes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Presentation Skills for Scientists. E. Zanders & L. MacLeod. Cambridge University Press. 2010. 80 pages. ISBN 9780521741033. Price £19.99 (paperback with DVD-ROM).

Presentation Skills for Scientists. E. Zanders & L. MacLeod. Cambridge University Press. 2010. 80 pages. ISBN 9780521741033. Price £19.99 (paperback with DVD-ROM). Genetics Research, 92(4), 323–324.

By: R. Anholt n

TL;DR: The Elements of Evolutionary Genetics by Brian and Deborah Charlesworth is a work of biblical proportions for the age of genetics, and in a fast-moving field, I anticipate that this book will be a key textbook for many years to come. (via Semantic Scholar)
Source: Crossref
Added: January 5, 2021

2010 journal article

The Soluble Proteome of the Drosophila Antenna

Chemical Senses, 35(1), 21–30.

By: R. Anholt n & T. Williams n

Contributors: R. Anholt n & T. Williams n

author keywords: chemosensation; mass spectrometry; odorant-binding proteins; olfaction; proteomics
MeSH headings : Amino Acid Sequence; Animals; Drosophila melanogaster / metabolism; Female; Male; Mass Spectrometry; Molecular Sequence Data; Nanotechnology; Proteome / chemistry; Proteome / metabolism; Receptors, Odorant / metabolism; Smell; Trypsin / metabolism
TL;DR: A simple method for the large-scale detection of soluble proteins from the Drosophila antenna by chromatographic separation of tryptic peptides followed by tandem mass spectrometry with femtomole detection sensitivities is described. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Alcohol Sensitivity in Drosophila: Translational Potential of Systems Genetics

GENETICS, 183(2), 733–745.

By: T. Morozova*, J. Ayroles*, K. Jordan*, L. Duncan*, M. Carbone*, R. Lyman*, E. Stone n, D. Govindaraju ...

MeSH headings : Alcohol Drinking / genetics; Animals; Cluster Analysis; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / genetics; Ethanol / pharmacology; Female; Gene Expression Regulation / drug effects; Gene Regulatory Networks; Genes, Insect / genetics; Genetic Variation; Genome, Insect / genetics; Genome-Wide Association Study / methods; Genotype; Humans; Inbreeding; Malate Dehydrogenase / genetics; Malate Dehydrogenase / metabolism; Male; Phenotype; Polymorphism, Single Nucleotide; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: Seven intronic single nucleotide polymorphisms of the Malic Enzyme 1 (ME1) gene that are associated with cocktail drinking in 1687 individuals of the Framingham Offspring cohort are identified, implicating that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster

Genetics Research, 91(6), 373–382.

By: A. Yamamoto n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Drosophila melanogaster / genetics; Epistasis, Genetic; Genome, Insect; Mutation; Phenotype; Quantitative Trait Loci; Reflex, Startle / genetics; Selection, Genetic
TL;DR: A partial glimpse of the complex genetic network underlying the genetic architecture of startle behaviour is provided and empirical support is provided for the hypothesis that suppressing epistasis is the mechanism underlying genetic canalization of traits under strong stabilizing selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Crossref
Added: August 28, 2020

2009 journal article

Systems genetics of complex traits in Drosophila melanogaster

NATURE GENETICS, 41(3), 299–307.

By: J. Ayroles n, M. Carbone n, E. Stone n, K. Jordan n, R. Lyman n, M. Magwire n, S. Rollmann n, L. Duncan n ...

MeSH headings : Amino Acid Sequence; Animals; Animals, Inbred Strains; Base Sequence; Chromosome Mapping; Drosophila melanogaster / genetics; Female; Gene Regulatory Networks / physiology; Genetic Variation / physiology; Genetics, Population / methods; Male; Molecular Sequence Data; Phenotype; Quantitative Trait, Heritable; RNA, Messenger / analysis; RNA, Messenger / genetics; RNA, Messenger / metabolism; Sequence Homology, Amino Acid; Tissue Distribution
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Understanding the neurogenetics of sleep: progress from Drosophila

Trends in Genetics, 25(6), 262–269.

By: S. Harbison n, T. Mackay n & R. Anholt n

MeSH headings : Animals; Drosophila / genetics; Drosophila / metabolism; Sleep / genetics; Sleep / physiology
TL;DR: Drosophila melanogaster exhibits all the behavioral characteristics of mammalian sleep, enabling the use of powerful genetic approaches to dissect conserved fundamental neurogenetic aspects of sleep. (via Semantic Scholar)
Source: Crossref
Added: February 24, 2020

2008 journal article

Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 105(34), 12393–12398.

By: A. Yamamoto n, L. Zwarts*, P. Callaerts*, K. Norga*, T. Mackay n & R. Anholt n

author keywords: behavioral genetics; epistasis; sensorimotor integration; startle behavior; P-element insertional mutagenesis
MeSH headings : Animals; DNA Transposable Elements; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Gene Regulatory Networks / physiology; Locomotion / genetics; Locomotion / physiology; Mutation; Nervous System Physiological Phenomena; Reflex, Startle / genetics; Reflex, Startle / physiology
TL;DR: It is found that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Olfactomedin-2 mediates development of the anterior central nervous system and head structures in zebrafish

MECHANISMS OF DEVELOPMENT, 125(1-2), 167–181.

By: J. Lee*, R. Anholt n & G. Cole*

author keywords: olfactomedin-2; Pax6.1; zebrafish; islet-1; branchiomotor neurons; cranial neural crest; crestin
MeSH headings : Animals; Body Patterning; Central Nervous System / embryology; Extracellular Matrix Proteins / genetics; Extracellular Matrix Proteins / physiology; Eye Proteins / genetics; Gene Expression Regulation, Developmental; Glycoproteins / genetics; Glycoproteins / physiology; Homeodomain Proteins / genetics; PAX6 Transcription Factor; Paired Box Transcription Factors / genetics; RNA, Messenger / genetics; Repressor Proteins / genetics; Zebrafish / embryology
TL;DR: It is shown in zebrafish that olfactomedin-2 (OM2) is a developmentally regulated gene, and that knockdown of protein expression by morpholino antisense oligonucleotides leads to perturbations of nervous system development. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster

GENETICS, 179(2), 1079–1088.

By: D. Sambandan n, M. Carbone n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Behavior, Animal; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Environment; Female; Gene Expression Profiling; Genes, Insect; Genetic Complementation Test; Genetic Variation; Genotype; Male; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; Phylogeny; Quantitative Trait Loci; Reverse Transcriptase Polymerase Chain Reaction; Smell / genetics; Smell / physiology; Transferrin / genetics
TL;DR: It is found that ∼50% of phenotypic variation in adult olfactory behavior is attributable to GEI, and transcriptional analysis revealed that only 20 genes show GEI at the level of gene expression [false discovery rate (FDR) < 0.05], some of which are associated with physiological responses to environmental chemicals. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Variation in genetic architecture of olfactory behaviour among wild-derived populations of Drosophila melanogaster

JOURNAL OF EVOLUTIONARY BIOLOGY, 21(4), 988–996.

author keywords: behaviour; chemical ecology; genetic variation; phenotypic plasticity; quantitative genetics
MeSH headings : Aging / physiology; Animals; Argentina; Behavior, Animal; Drosophila melanogaster / genetics; Genetic Variation / genetics; Genotype; Larva; Olfactory Bulb / metabolism; Phenotype; Population Dynamics; Sex Characteristics
TL;DR: The results suggest that the potential for evolutionary adaptation to the chemosensory environment is greater at the larval feeding stage than at the adult reproductive stage and estimates of evolvability are orders of magnitude higher for larvae than for adults. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Ain't misbehavin? Genotype-environment interactions and the genetics of behavior

TRENDS IN GENETICS, 23(7), 311–314.

By: T. Mackay n & R. Anholt n

MeSH headings : Animals; Behavior, Animal; Crosses, Genetic; Drosophila; Environment; Genetics, Behavioral / methods; Genotype; Mice; Models, Genetic; Phenotype; Species Specificity
TL;DR: The importance of understanding genotype-environment interactions is stressed, together with studies from Drosophila, which show that some behavioral differences between laboratories remain greatly replicable, whereas others are less robust over time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila

GENETICS, 177(3), 1655–1665.

By: P. Wang*, R. Lyman*, S. Shabalina n, T. Mackay* & R. Anholt*

MeSH headings : Animals; Benzaldehydes; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genes, Insect; Genetics, Population; Male; Models, Molecular; Molecular Sequence Data; Multigene Family; Nucleic Acid Conformation; Odorants; Phenotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide; RNA Precursors / chemistry; RNA Precursors / genetics; Receptors, Odorant / genetics
TL;DR: Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila

GENETICS, 176(2), 947–956.

By: S. Rollmann n, A. Yamamoto n, T. Goossens*, L. Zwarts*, Z. Callaerts-Vegh, P. Callaerts*, K. Norga*, T. Mackay n, R. Anholt n

MeSH headings : Aging / physiology; Animals; Animals, Genetically Modified; Antibodies, Monoclonal; Avoidance Learning; Behavior, Animal; Benzaldehydes; Cell Adhesion Molecules, Neuronal / immunology; Crosses, Genetic; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Drosophila melanogaster / physiology; Gene Expression Regulation, Developmental; Membrane Glycoproteins / genetics; Mutation; Odorants; Semaphorins / genetics; Smell / physiology
TL;DR: The results demonstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 book

Dazzle 'em with style the art of oral scientific presentation

Burlington, MA: Elsevier Academic Press.

By: R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster

GENETICS, 174(3), 1349–1363.

By: D. Sambandan n, A. Yamamoto n, J. Fanara*, T. Mackay n & R. Anholt n

MeSH headings : Animals; Behavior, Animal; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Genes, Insect; Mutagenesis, Insertional; Mutation; Odorants; Smell / genetics; Smell / physiology
TL;DR: The results show that the manifestation of epistatic networks dynamically changes with alterations in the environment, and surprisingly, epistatic interactions shifted with changes in the concentration of the olfactory stimulus. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster

NATURE GENETICS, 38(7), 824–829.

By: S. Rollmann n, M. Magwire n, T. Morgan n, E. Ozsoy n, A. Yamamoto n, T. Mackay n, R. Anholt n

MeSH headings : Animals; DNA Transposable Elements / genetics; DNA, Intergenic / genetics; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Female; Genes, Insect; Insulin / metabolism; Longevity / genetics; Male; Mutation; Phenotype; Quantitative Trait, Heritable; Receptors, Cell Surface / genetics; Receptors, G-Protein-Coupled / genetics; Repetitive Sequences, Nucleic Acid; Signal Transduction; Taste / genetics
TL;DR: It is demonstrated that single P-element insertions in the intergenic region between the gustatory receptor 5a and trapped in endoderm 1, which encodes an orphan receptor, exert complex pleiotropic effects on fitness traits, including selective nutrient intake, life span, and resistance to starvation and heat stress. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster

JOURNAL OF NEUROBIOLOGY, 63(2), 146–158.

author keywords: olfaction; P-element mutagenesis; behavioral genetics; chemoreception
MeSH headings : Amino Acid Sequence; Analysis of Variance; Animals; Avoidance Learning / physiology; Behavior, Animal; Cloning, Molecular; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila Proteins / physiology; Drosophila melanogaster / metabolism; Electrophysiology / methods; Gene Expression / physiology; In Situ Hybridization / methods; Mutagenesis, Insertional / physiology; Naphthalenes; Odorants; Oxepins; Phenotype; RNA, Messenger / metabolism; Receptors, Odorant / genetics; Receptors, Odorant / metabolism; Reverse Transcriptase Polymerase Chain Reaction / methods; Sense Organs / metabolism; Smell / physiology
TL;DR: It is shown that the smi21F mutant also exhibits reduced attractant responses to some, but not all, of a select group of odorants, and electroantennogram amplitudes are increased in smi 21F flies. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2004 review

Genetic modules and networks for behavior: lessons from Drosophila

[Review of ]. BIOESSAYS, 26(12), 1299–1306.

MeSH headings : Animals; Behavior, Animal / physiology; Biological Evolution; Drosophila melanogaster / physiology; Epistasis, Genetic; Gene Expression Profiling; Oligonucleotide Array Sequence Analysis; Phenotype; Sex Factors
TL;DR: This review describes how Drosophila can serve as a model for uncovering fundamental principles of the genetic architecture of behavior, and how such networks are exquisitely sensitive to genetic background and sex effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 review

Quantitative genetic analyses of complex behaviours in Drosophila

[Review of ]. NATURE REVIEWS GENETICS, 5(11), 838–849.

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Gene Expression Profiling; Genetics, Behavioral; Genotype; Phenotype; Sex Characteristics; Transcription, Genetic
TL;DR: Drosophila melanogaster provides an attractive system for elucidating the unifying principles of the genetic architectures that drive behaviours, as genetically identical individuals can be reared rapidly in controlled environments and extensive publicly accessible genetic resources are available. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Scribble is essential for olfactory Behavior in Drosphila melanogaster

Genetics, 164(4), 1447–1457.

By: I. Ganguly, T. MacKay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome

NATURE GENETICS, 35(2), 180–184.

By: R. Anholt n, C. Dilda n, S. Chang*, J. Fanara n, N. Kulkarni n, I. Ganguly n, S. Rollmann n, K. Kamdar*, T. Mackay n

MeSH headings : Animals; Biotransformation; Drosophila melanogaster / genetics; Epistasis, Genetic; Gene Expression Regulation; Odorants; Smell / physiology; Transcription, Genetic
TL;DR: Quantitative complementation tests of mutations at coregulated genes with the smi mutations showed that in most cases (67%) epistatic interactions for olfactory behavior mirrored epistasis at the level of transcription, thus identifying new candidate genes regulating olfaction behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)

Genetics, 163(2), 637–645.

By: T. Borras, T. Morozova, S. Heinsohn, R. Lyman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Impaired olfactory behavior in mice deficient in the a subunit of G(0)

BRAIN RESEARCH, 941(1-2), 62–71.

author keywords: G protein; knock-out mouse; olfaction; chemoreception; behavioral genetics; olfactory bulb
MeSH headings : Analysis of Variance; Animals; Behavior, Animal; Female; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins / deficiency; Heterotrimeric GTP-Binding Proteins / genetics; Immunohistochemistry; Male; Mice; Mice, Knockout; Odorants; Olfactory Bulb / cytology; Olfactory Receptor Neurons; Phenotype; Smell / genetics
TL;DR: Gαo is necessary for the expression of olfactory behavior under normal conditions and dependent on genetic background, but is not essential for the formation and maintenance of glomeruli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster

Genetics, 161(4), 1507–1516.

By: N. Kulkarni, A. Yamamoto, K. Robinson, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior

Genetics, 162(3), 1321–1328.

By: J. Fanara, K. Robinson, S. Rollmann, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Functional genomics of odor-guided behavior in Drosophila melanogaster

CHEMICAL SENSES, 26(2), 215–221.

By: R. Anholt n, J. Fanara, G. Fedorowicz, I. Ganguly, N. Kulkarni, T. Mackay, S. Rollmann

MeSH headings : Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Epistasis, Genetic; Genes, Insect; Models, Biological; Mutagenesis, Insertional; Mutation; Odorants; Smell / genetics; Smell / physiology
TL;DR: The identification and functional characterization of proteins encoded by smi genes that form part of the olfactory subgenome and correlation of polymorphisms in these genes with variation in odor-guided behavior in natural populations will advance the understanding of the genetic architecture of chemosensory behavior. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Olfaction in Drosophila: from receptors to behavior

CHEMICAL SENSES, 26(2), 193–193.

By: R. Anholt n

Source: Web Of Science
Added: August 6, 2018

2001 journal article

The genetic architecture of odor-guided behavior in Drosophila melanogaster

BEHAVIOR GENETICS, 31(1), 17–27.

author keywords: olfaction; chemoreception; quantitative genetics; P-element insertional mutagenesis; epistasis; functional genomics
MeSH headings : Animals; Avoidance Learning / physiology; DNA Transposable Elements / genetics; Drosophila melanogaster / genetics; Female; Genotype; Male; Models, Genetic; Mutagenesis, Insertional / genetics; Phenotype; Smell / genetics
TL;DR: The identification and functional characterization of proteins encoded by smi genes that form part of the olfactory subgenome and correlation of polymorphisms in these genes with variation in odor-guided behavior in natural populations will advance the understanding of the genetic architecture of chemosensory behavior. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Characterization and differential expression of a human gene family of olfactomedin-related proteins

GENETICAL RESEARCH, 76(1), 41–50.

By: N. Kulkarni n, C. Karavanich n, W. Atchley n & R. Anholt n

MeSH headings : Amino Acid Sequence; Animals; Blotting, Northern; Brain / metabolism; Cytoskeletal Proteins; Extracellular Matrix Proteins / biosynthesis; Extracellular Matrix Proteins / genetics; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Expression; Glycoproteins / biosynthesis; Glycoproteins / genetics; Humans; Molecular Sequence Data; Multigene Family; Phylogeny; Rats; Sequence Homology, Amino Acid; Tissue Distribution
TL;DR: The link between TIGR/myocilin and ocular hypertension and the expression of several of these proteins in mucus-lined tissues suggest that they play an important role in regulating physical properties of the extracellular environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Differential expression of G proteins in the mouse olfactory system

BRAIN RESEARCH, 837(1-2), 117–126.

author keywords: G protein; olfaction; olfactory bulb; accessory olfactory bulb; olfactory neuron; chemotopic projection
MeSH headings : Animals; Antibody Specificity; Axons / metabolism; GTP-Binding Protein alpha Subunits; Heterotrimeric GTP-Binding Proteins / analysis; Heterotrimeric GTP-Binding Proteins / genetics; Immunohistochemistry; Mice; Olfactory Bulb / cytology; Olfactory Bulb / metabolism; Olfactory Pathways / cytology; Olfactory Pathways / metabolism; Olfactory Receptor Neurons / cytology; Olfactory Receptor Neurons / metabolism
TL;DR: Characterization of the expression patterns of G(i2) and G(o) in the olfactory projection is essential for future studies aimed at relating transmembrane signaling events to signal propagation, axon sorting and target innervation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Epistatic interactions between smell-impaired loci in Drosophila melanogaster

Genetics, 148(4), 1885–1891.

By: G. Fedorowicz, J. Fry, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Molecular evolution of olfactomedin

MOLECULAR BIOLOGY AND EVOLUTION, 15(6), 718–726.

author keywords: olfactomedin; molecular evolution; olfaction; neurogenesis; neural development; extracellular matrix
MeSH headings : Amino Acid Sequence; Amphibians / genetics; Animals; Brain Chemistry; Caenorhabditis elegans / genetics; Evolution, Molecular; Extracellular Matrix Proteins / genetics; Fishes / genetics; Glycoproteins / genetics; Humans; Mice; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins / genetics; Olfactory Mucosa / chemistry; Rana catesbeiana / genetics; Rats; Rodentia / genetics; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity
TL;DR: The phylogenetic history of olfactomedin was examined to identify conserved structural motifs, and it was indicated that extensive modification of its N-terminal half and the acquisition of a C- terminal SDEL endoplasmic-reticulum-targeting sequence may have enabled olfactsomedin to adopt new functions in the mammalian central nervous system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 chapter

Olf evolution of olfactomedin: Structural constraints and conservation of primary sequence motifs

In Olfaction and taste XII: An international symposium (Vol. 855, pp. 294–300). New York, NY: New York Academy of Sciences.

By: C. Karavanich & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Pheromone regulated production of inositol-(1, 4, 5)trisphosphate in the mammalian vomeronasal organ

ENDOCRINOLOGY, 138(8), 3497–3504.

By: K. Wekesa & R. Anholt

Source: Web Of Science
Added: August 6, 2018

1994 book

Dazzle 'em with style the art of oral scientific presentation

New York: WH Freeman and Co.

By: R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

A drosophila model for toxicogenomics: Genetic variation in susceptibility to heavy metal exposure

Zhou, S. S., Luoma, S. E., Armour, G. E. S., Thakkar, E., Mackay, T. F. C., & Anholt, R. R. H. PLoS Genetics, 13(7).

By: S. Zhou, S. Luoma, G. Armour, E. Thakkar, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Analysis of natural variation reveals neurogenetic networks for Drosophila olfactory behavior

Swarup, S., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Proceedings of the National Academy of Sciences of the United States of America, 110(3), 1017–1022.

By: S. Swarup, W. Huang, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Complex genetic architecture of Drosophila aggressive behavior

Zwarts, L., Magwire, M. M., Carbone, M. A., Versteven, M., Herteleer, L., Anholt, R. R. H., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 108(41), 17070–17075.

By: L. Zwarts, M. Magwire, M. Carbone, M. Versteven, L. Herteleer, R. Anholt, P. Callaerts, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistasis dominates the genetic architecture of Drosophila quantitative traits

Huang, W., Richards, S., Carbone, M. A., Zhu, D. H., Anholt, R. R. H., Ayroles, J. F., … Muzny, D. Proceedings of the National Academy of Sciences of the United States of America, 109(39), 15553–15559.

By: W. Huang, S. Richards, M. Carbone, D. Zhu, R. Anholt, J. Ayroles, L. Duncan, K. Jordan ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster

Yamamoto, A., Anholt, R. R. H., & Mackay, T. F. C. Genetical Research, 91(6), 373–382.

By: A. Yamamoto, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster

Dembeck, L. M., Boroczky, K., Huang, W., Schal, C., Anholt, R. R. H., & Mackay, T. F. C. Elife, 4.

By: L. Dembeck, K. Boroczky, W. Huang, C. Schal, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic architecture of natural variation in visual senescence in Drosophila

Carbone, M. A., Yamamoto, A., Huang, W., Lyman, R. A., Meadors, T. B., Yamamoto, R., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 113(43), E6620–6629.

By: M. Carbone, A. Yamamoto, W. Huang, R. Lyman, T. Meadors, R. Yamamoto, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetic basis of transcriptome diversity in Drosophila melanogaster

Huang, W., Carbone, M. A., Magwire, M. M., Peiffer, J. A., Lyman, R. F., Stone, E. A., … Mackay, T. F. C. Proceedings of the National Academy of Sciences of the United States of America, 112(44), E6010–6019.

By: W. Huang, M. Carbone, M. Magwire, J. Peiffer, R. Lyman, E. Stone, R. Anholt, T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

review

Genetics and genomics of alcohol sensitivity

Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Molecular Genetics and Genomics, 289(3), 253–269.

By: T. Morozova, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genetics of alcohol consumption in Drosophila melanogaster

Fochler, S., Morozova, T. V., Davis, M. R., Gearhart, A. W., Huang, W., Mackay, T. F. C., & Anholt, R. R. H. Genes Brain and Behavior, 16(7), 675–685.

By: S. Fochler, T. Morozova, M. Davis, A. Gearhart, W. Huang, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster

Weber, A. L., Khan, G. F., Magwire, M. M., Tabor, C. L., Mackay, T. F. C., & Anholt, R. R. H. PLoS One, 7(4).

By: A. Weber, G. Khan, M. Magwire, C. Tabor, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association analysis of tolerance to methylmercury toxicity in Drosophila implicates myogenic and neuromuscular developmental pathways

Montgomery, S. L., Vorojeikina, D., Huang, W., Mackay, T. F. C., Anholt, R. R. H., & Rand, M. D. PLoS One, 9(10).

By: S. Montgomery, D. Vorojeikina, W. Huang, T. Mackay, R. Anholt & M. Rand

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association for sensitivity to chronic oxidative stress in Drosophila melanogaster

Jordan, K. W., Craver, K. L., Magwire, M. M., Cubilla, C. E., Mackay, T. F. C., & Anholt, R. R. H. PLoS One, 7(6).

By: K. Jordan, K. Craver, M. Magwire, C. Cubilla, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster

Wang, P., Lyman, R. F., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 184(3), 759–767.

By: P. Wang, R. Lyman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Natural variation, functional pleiotropy and transcriptional contexts of odorant binding protein genes in Drosophila melanogaster

Arya, G. H., Weber, A. L., Wang, P., Magwire, M. M., Negron, Y. L. S., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 186(4), 1475–1623.

By: G. Arya, A. Weber, P. Wang, M. Magwire, Y. Negron, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Obp56h modulates mating behavior in Drosophila melanogaster

Shorter, J. R., Dembeck, L. M., Everett, L. J., Morozova, T. V., Arya, G. H., Turlapati, L., … Anholt, R. R. H. G3-Genes Genomes Genetics, 6(10), 3335–3342.

Source: NC State University Libraries
Added: August 6, 2018

journal article

Odorant receptor polymorphisms and natural variation in olfactory behavior in Drosophila melanogaster

Rollmann, S. M., Wang, P., Date, P., West, S. A., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 186(2), 687–364.

By: S. Rollmann, P. Wang, P. Date, S. West, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

Of flies and man: Drosophila as a model for human complex traits

Mackay, T. E. C., & Anholt, R. R. H. [Review of ]. Annual Review of Genomics and Human Genetics, 7, 339–367.

By: T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: Implications for glaucoma

Carbone, M. A., Ayroles, J. F., Yamamoto, A., Morozova, T. V., West, S. A., Magwire, M. M., … Anholt, R. R. H. PLoS One, 4(1).

By: M. Carbone, J. Ayroles, A. Yamamoto, T. Morozova, S. West, M. Magwire, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Morozova, T. V., Anholt, R. R., & MacKay, T. F. Genome Biology, 8(10).

By: T. Morozova, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Plasticity of the chemoreceptor repertoire in Drosophila melanogaster

Zhou, S. S., Stone, E. A., Mackay, T. F. C., & Anholt, R. R. H. PLoS Genetics, 5(10).

By: S. Zhou, E. Stone, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Polymorphisms in early neurodevelopmental genes affect natural variation in alcohol sensitivity in adult drosophila

Morozova, T. V., Huang, W., Pray, V. A., Whitham, T., Anholt, R. R. H., & Mackay, T. F. C. BMC Genomics, 16.

By: T. Morozova, W. Huang, V. Pray, T. Whitham, R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Scribble is essential for olfactory behavior in Drosophila melanogaster

Ganguly, I., MacKay, T. F. C., & Anholt, R. R. H. Genetics, 164(4), 1447–1457.

By: I. Ganguly, T. MacKay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis for variation in olfactory behavior in Drosophila melanogaster

Arya, G. H., Magwire, M. M., Huang, W., Serrano-Negron, Y. L., Mackay, T. F. C., & Anholt, R. R. H. Chemical Senses, 40(4), 233–243.

By: G. Arya, M. Magwire, W. Huang, Y. Serrano-Negron, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster

Zhou, S. S., Morozova, T. V., Hussain, Y. N., Luoma, S. E., McCoy, L., Yamamoto, A., … Anholt, R. R. H. Environmental Health Perspectives, 124(7), 1062–1070.

By: S. Zhou, T. Morozova, Y. Hussain, S. Luoma, L. McCoy, A. Yamamoto, T. Mackay, R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

The genetic basis of alcoholism: Multiple phenotypes, many genes, complex networks

Morozova, T. V., Goldman, D., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Genome Biology, 13(2).

By: T. Morozova, D. Goldman, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

The road less traveled: from genotype to phenotype in flies and humans

Anholt, R. R. H., & Mackay, T. F. C. Mammalian Genome, 29(1-2), 5–23.

By: R. Anholt & T. Mackay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Transcriptional networks for alcohol sensitivity in drosophila melanogaster

Morozova, T. V., Mackay, T. F. C., & Anholt, R. R. H. Genetics, 187(4), 1193–1345.

By: T. Morozova, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

journal article

Transcriptional response to alcohol exposure in Drosophila melanogaster

Morozova, T. V., Anholt, R. R. H., & MacKay, T. F. C. Genome Biology, 7(10).

By: T. Morozova, R. Anholt & T. MacKay

Source: NC State University Libraries
Added: August 6, 2018

journal article

Tuning the chemosensory window A fly's perspective

Zhou, S. S., Mackay, T. F. C., & Anholt, R. R. H. Fly, 4(3), 230–235.

By: S. Zhou, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

review

Understanding the neurogenetics of sleep: Progress from Drosophila

Harbison, S. T., Mackay, T. F. C., & Anholt, R. R. H. [Review of ]. Trends in Genetics, 25(6), 262–269.

By: S. Harbison, T. Mackay & R. Anholt

Source: NC State University Libraries
Added: August 6, 2018

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