@article{conner_veleva_paunov_stoyanov_velev_2020, title={Scalable Formation of Concentrated Monodisperse Lignin Nanoparticles by Recirculation-Enhanced Flash Nanoprecipitation}, volume={37}, ISSN={["1521-4117"]}, DOI={10.1002/ppsc.202000122}, abstractNote={Abstract}, number={7}, journal={PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION}, author={Conner, Cathryn G. and Veleva, Anka N. and Paunov, Vesselin N. and Stoyanov, Simeon D. and Velev, Orlin D.}, year={2020}, month={Jul} }
 @article{merrill_krajewski_yuan_frank_lalush_patterson_veleva_2016, title={Data on biodistribution and radiation absorbed dose profile of a novel 64Cu-labeled high affinity cell-specific peptide for positron emission tomography imaging of tumor vasculature}, volume={7}, ISSN={2352-3409}, url={https://doi.org/10.1016/j.dib.2016.02.080}, DOI={10.1016/J.DIB.2016.02.080}, abstractNote={New peptide-based diagnostic and therapeutic approaches hold promise for highly selective targeting of cancer leading to more precise and effective diagnostic and therapeutic modalities. An important feature of these approaches is to reach the tumor tissue while limiting or minimizing the dose to normal organs. In this context, efforts to design and engineer materials with optimal in vivo targeting and clearance properties are important. This Data In Brief article reports on biodistribution and radiation absorbed dose profile of a novel high affinity radiopeptide specific for bone marrow-derived tumor vasculature. Background information on the design, preparation, and in vivo characterization of this peptide-based targeted radiodiagnostic is described in the article "Synthesis and comparative evaluation of novel 64Cu-labeled high affinity cell-specific peptides for positron emission tomography of tumor vasculature" (Merrill et al., 2016) [1]. Here we report biodistribution measurements in mice and calculate the radiation absorbed doses to normal organs using a modified Medical Internal Radiation Dosimetry (MIRD) methodology that accounts for physical and geometric factors and cross-organ beta doses.}, journal={Data in Brief}, publisher={Elsevier BV}, author={Merrill, Joseph R. and Krajewski, Krzysztof and Yuan, Hong and Frank, Jonathan E. and Lalush, David S. and Patterson, Cam and Veleva, Anka N.}, year={2016}, month={Jun}, pages={480–484} }
 @article{merrill_krajewski_yuan_frank_lalush_patterson_veleva_2016, title={Synthesis and comparative evaluation of novel Cu-64-labeled high affinity cell-specific peptides for positron emission tomography imaging of tumor vasculature}, volume={84}, ISSN={["1878-5905"]}, DOI={10.1016/j.biomaterials.2016.01.031}, abstractNote={Tumor angiogenesis, the formation of new tumor blood supply, has been recognized as a hallmark of cancer and represents an important target for clinical management of various angiogenesis-dependent solid tumors. Previously, by screening a bacteriophage peptide library we have discovered the FHT-peptide sequence that binds specifically to bone marrow-derived tumor vasculature with high affinity. Here in an effort to determine the potential of the FHT-peptide for in vivo positron emission tomography (PET) imaging of aggressive tumor vasculature we studied four FHT-derivatives: NOTA-FHT, NOTA-(FHT)2, NOTA-PEG-FHT, and NOTA-PEG-(FHT)2. These peptide analogs were synthesized, labeled with the PET radionuclide (64)Cu, and characterized side-by-side with small animal PET and computed tomography imaging (microPET/CT) at 1 h, 4 h, and 24 h post injection in a subcutaneous Lewis lung carcinoma (LLC) tumor model. Because of its excellent in vivo kinetic properties and high tumor-to-background ratio, the (64)Cu-NOTA-FHT radiopeptide was selected for more detailed evaluation. Blocking studies with excess of unlabeled peptide showed specific and peptide mediated (64)Cu-NOTA-FHT tumor uptake. Biodistribution experiments in the same tumor model confirmed microPET/CT imaging results. Human radiation absorbed dose extrapolated from rodent biodistribution of (64)Cu-NOTA-FHT revealed favorable dosimetry profile. The findings from this investigation warrant further development of (64)Cu-NOTA-FHT as a potential targeted diagnostic radiopharmaceutical for PET imaging of aggressive tumor vasculature.}, journal={BIOMATERIALS}, author={Merrill, Joseph R. and Krajewski, Krzysztof and Yuan, Hong and Frank, Jonathan E. and Lalush, David S. and Patterson, Cam and Veleva, Anka N.}, year={2016}, month={Apr}, pages={241–249} }
 @article{patterson_frederick_yuan_dyer_lockyer_lalush_veleva_2013, title={Development of a New Positron Emission Tomography Tracer for Targeting Tumor Angiogenesis: Synthesis, Small Animal Imaging, and Radiation Dosimetry}, volume={18}, ISSN={["1420-3049"]}, DOI={10.3390/molecules18055594}, abstractNote={Angiogenesis plays a key role in cancer progression and correlates with disease aggressiveness and poor clinical outcomes. Affinity ligands discovered by screening phage display random peptide libraries can be engineered to molecularly target tumor blood vessels for noninvasive imaging and early detection of tumor aggressiveness. In this study, we tested the ability of a phage-display-selected peptide sequence recognizing specifically bone marrow- derived pro-angiogenic tumor-homing cells, the QFP-peptide, radiolabeled with 64Cu radioisotope to selectively image tumor vasculature in vivo by positron emission tomography (PET). To prepare the targeted PET tracer we modified QFP-phage with the DOTA chelator and radiolabeled the purified QFP-phage-DOTA intermediate with 64Cu to obtain QFP-targeted radioconjugate with high radiopharmaceutical yield and specific activity. We evaluated the new PET tracer in vivo in a subcutaneous (s.c.) Lewis lung carcinoma (LLC) mouse model and conducted tissue distribution, small animal PET/CT imaging study, autoradiography, histology, fluorescence imaging, and dosimetry assessments. The results from this study show that, in the context of the s.c. LLC immunocompetent mouse model, the QFP-tracer can target tumor blood vessels selectively. However, further optimization of the biodistribution and dosimetry profile of the tracer is necessary to ensure efficient radiopharmaceutical applications enabled by the biological specificity of the QFP-peptide.}, number={5}, journal={MOLECULES}, author={Patterson, Cam and Frederick, C. Brandon and Yuan, Hong and Dyer, Laura A. and Lockyer, Pamela and Lalush, David S. and Veleva, Anka N.}, year={2013}, month={May}, pages={5594–5610} }
 @article{veleva_nepal_frederick_schwab_lockyer_yuan_lalush_patterson_2011, title={Efficient In Vivo Selection of a Novel Tumor-Associated Peptide from a Phage Display Library}, volume={16}, ISSN={["1420-3049"]}, DOI={10.3390/molecules160109}, abstractNote={We developed a screening procedure to identify ligands from a phage display random peptide library that are selective for circulating bone marrow derived cells homing to angiogenic tumors. Panning the library on blood outgrowth endothelial cell suspension in vitro followed by in vivo selection based on homing of bone marrow-bound phage to angiogenic tumors, yielded the peptide QFPPKLTNNSML. Upon intravenous injection phage displaying this peptide homed to Lewis lung carcinoma (LLC) tumors in vivo whereas control phage did not localize to tumor tissue. Phage carrying the QFPPKLTNNSML peptide labeled with 64Cu radionuclide when administered intravenously into a tumor bearing mouse was detected noninvasively with positron emission tomography (PET) around the tumor. These proof-of-principle experiments demonstrate the ability of the QFPPKLTNNSML peptide to deliver payload (radiolabeled phage conjugates) in vivo to sites of ongoing angiogenesis and point to its potential clinical utility in a variety of physiologic and pathologic processes where neovascular growth is a critical component.}, number={1}, journal={MOLECULES}, author={Veleva, Anka N. and Nepal, Desh B. and Frederick, C. Brandon and Schwab, Jacob and Lockyer, Pamela and Yuan, Hong and Lalush, David S. and Patterson, Cam}, year={2011}, month={Jan}, pages={900–914} }
 @article{aitsebaomo_srivastava_zhang_jha_wang_winnik_veleva_pi_lockyer_faber_et al._2011, title={Recombinant Human Interleukin-11 Treatment Enhances Collateral Vessel Growth After Femoral Artery Ligation}, volume={31}, ISSN={["1524-4636"]}, DOI={10.1161/atvbaha.110.216986}, abstractNote={
            Objective—
            
              To investigate the role of recombinant human interleukin-11 (rhIL-11) on in vivo mobilization of CD34
              +
              /vascular endothelial growth factor receptor (VEGFR) 2
              +
              mononuclear cells and collateral vessel remodeling in a mouse model of hindlimb ischemia.
            
          }, number={2}, journal={ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY}, author={Aitsebaomo, Julius and Srivastava, Siddharth and Zhang, Hua and Jha, Sushmita and Wang, Zhongjing and Winnik, Stephan and Veleva, Anka N. and Pi, Xinchun and Lockyer, Pamela and Faber, James E. and et al.}, year={2011}, month={Feb}, pages={306–312} }
 @article{veleva_heath_johnson_nam_patterson_lannutti_cooper_2009, title={Interactions between endothelial cells and electrospun methacrylic terpolymer fibers for engineered vascular replacements}, volume={91A}, ISSN={1549-3296 1552-4965}, url={http://dx.doi.org/10.1002/jbm.a.32276}, DOI={10.1002/jbm.a.32276}, abstractNote={Abstract}, number={4}, journal={Journal of Biomedical Materials Research Part A}, publisher={Wiley}, author={Veleva, A. N. and Heath, D. E. and Johnson, J. K. and Nam, J. and Patterson, C. and Lannutti, J. J. and Cooper, S. L.}, year={2009}, month={Dec}, pages={1131–1139} }
 @article{veleva_heath_cooper_patterson_2008, title={Selective endothelial cell attachment to peptide-modified terpolymers}, volume={29}, ISSN={["1878-5905"]}, DOI={10.1016/j.biomaterials.2008.05.022}, abstractNote={In a previous report we screened a combinatorial peptide library to identify novel ligands that bind with high affinity and specificity to human blood outgrowth endothelial cells (HBOEC). In this study we demonstrate the use of the phage display-selected-HBOEC-specific peptides as a tool to direct and modulate endothelial cell (EC) behavior with a focus on designing functional biomaterials intended for use in cardiovascular applications. First, we ensured that our peptide ligands did not interfere with EC function as tested by proliferation, migration, tube formation, and response to vascular endothelial growth factor. Second, peptides that supported EC function were incorporated into methacrylic terpolymers via chain transfer free radical polymerization. The HBOEC-specific peptide, TPSLEQRTVYAK, when covalently coupled to a terpolymer matrix, retained binding affinity towards HBOEC in a serum-free medium. Under the same binding conditions, the attachment of human umbilical vein endothelial cells (HUVEC) was limited, thus establishing HBOEC specificity. To our knowledge, this is the first report demonstrating specificity in binding to peptide-modified biomaterials of mature EC, i.e., HUVEC, and EC of progenitor origin such as HBOEC. The findings from this work could facilitate the development of autologous cell therapies with which to treat cardiovascular disease.}, number={27}, journal={BIOMATERIALS}, author={Veleva, Anka N. and Heath, Daniel E. and Cooper, Stuart L. and Patterson, Cam}, year={2008}, month={Sep}, pages={3656–3661} }
 @article{veleva_cooper_patterson_2007, title={Selection and initial characterization of novel peptide ligands that bind specifically to human blood outgrowth endothelial cells}, volume={98}, ISSN={["1097-0290"]}, DOI={10.1002/bit.21420}, abstractNote={Abstract}, number={1}, journal={BIOTECHNOLOGY AND BIOENGINEERING}, author={Veleva, Anka N. and Cooper, Stuart L. and Patterson, Cam}, year={2007}, month={Sep}, pages={306–312} }
 @article{veleva_khan_cooper_2005, title={Oxidative and hydrolytic stability of a novel acrylic terpolymer for biomedical applications}, volume={74A}, ISSN={1549-3296 1552-4965}, url={http://dx.doi.org/10.1002/jbm.a.30349}, DOI={10.1002/jbm.a.30349}, abstractNote={Abstract}, number={1}, journal={Journal of Biomedical Materials Research Part A}, publisher={Wiley}, author={Veleva, Anka N. and Khan, Saad A. and Cooper, Stuart L.}, year={2005}, pages={117–123} }