Works (1)
Updated: July 5th, 2023 15:54
2007 journal article
Differential effects on messenger ribonucleic acid expression by bone marrow-derived human mesenchymal stem cells seeded in agarose constructs due to ramped and steady applications of cyclic hydrostatic pressure
TISSUE ENGINEERING, 13(6), 1151–1158.
MeSH headings : Adolescent; Adult; Biocompatible Materials / chemistry; Bone Marrow Cells / cytology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cell Culture Techniques / methods; Cells, Cultured; Chondrocytes / cytology; Chondrocytes / drug effects; Chondrocytes / metabolism; Chondrogenesis / drug effects; Chondrogenesis / physiology; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; Gene Expression Regulation, Developmental / drug effects; Gene Expression Regulation, Developmental / physiology; Humans; Male; Mechanotransduction, Cellular / drug effects; Mechanotransduction, Cellular / physiology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Pressure; RNA, Messenger / metabolism; Sepharose / chemistry; Tissue Engineering / methods; Transforming Growth Factor beta / administration & dosage
TL;DR:
Findings indicate that hydrostatic pressure may induce chondrogenesis in hMSC-seeded agarose constructs without TGF-beta, and that hMSCs are capable of withstanding high initial pressures that may initiate chondrogensesis faster than lower pressures.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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