Adriana San Miguel

Also known as: Adriana San-Miguel; Adriana San Miguel Delgadillo

microfluidics, systems biology, quantitative image analysis, phenotyping, neurobiology, aging

Works (46)

Updated: May 16th, 2024 05:00

2024 article

Amyloid β Induces Hormetic-Like Effects Through Major Stress Pathways in aC. elegansModel of Alzheimer’s Disease

Lichty, J. D., & Miguel, A. S. (2024, May 10).

By: J. Lichty n & A. Miguel n

Source: ORCID
Added: May 15, 2024

2024 article

Derivation of human trophoblast stem cells from placentas at birth

Karakis, V., Britt, J. W., Jabeen, M., Miguel, A. S., & Rao, B. M. (2024, May 2).

By: V. Karakis n, J. Britt n, M. Jabeen n, A. Miguel n & B. Rao n

Source: ORCID
Added: May 8, 2024

2024 journal article

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans

NEUROTOXICOLOGY, 100, 100–106.

author keywords: Dopaminergic degeneration; C. elegans; Swimming-induced paralysis; Microfluidics; Quantitative image analysis
TL;DR: It is shown that nematodes with dopaminergic dendrite degeneration markers, such as blebbing or breakage, paralyze at higher rates in a dopamine solution, providing evidence that dopaminergic neurodegeneration morphologies are correlated with functional neuronal outputs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2023 journal article

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

PLOS ONE, 18(7).

Ed(s): P. Lajoie

TL;DR: An automated, unbiased image processing algorithm is developed that can provide comparative insight into how each exposure affects dopaminergic neurodegeneration patterns and validate the accuracy of the algorithm by comparing code-generated, categorical degeneration results with manually scored dendrites of the same experiments. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: August 7, 2023

2023 dataset

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

Dryad.

Contributors: A. Miguel, A. Clark, Z. Kalmanson, K. Morton, J. Hartman & J. Meyer

Source: ORCID
Added: February 1, 2024

2023 article

An unbiased, automated platform for scoring dopaminergic neurodegeneration inC. elegans

Clark, A. S., Kalmanson, Z., Morton, K., Hartman, J., Meyer, J., & San-Miguel, A. (2023, February 3).

Source: ORCID
Added: May 31, 2023

2023 dataset

Data for: Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

Dryad.

Contributors: J. Huayta, J. Crapster & A. Miguel

Source: ORCID
Added: February 1, 2024

2023 journal article

Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

COMMUNICATIONS BIOLOGY, 6(1).

MeSH headings : Animals; Caenorhabditis elegans / genetics; Longevity / genetics; Caenorhabditis elegans Proteins / metabolism; Signal Transduction; Insulin / metabolism; Forkhead Transcription Factors / metabolism
TL;DR: The results indicate that DR regimes induce strong endogenous DAF-16 activity, although Daf-16 is less responsive in aged individuals, and analysis of tissue-specific expression aided by a machine learning tissue classifier reveals that, under DR, the largest contribution to D AF-16 nuclear intensity originates from the intestine and neurons. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 27, 2023

2023 journal article

Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions

JOURNAL OF BIOLOGICAL CHEMISTRY, 299(5).

By: V. Karakis n, M. Jabeen n, J. Britt n, A. Cordiner n, A. Mischler n, F. Li*, A. Miguel n, B. Rao n

MeSH headings : Humans; Cell Differentiation / drug effects; Colforsin / pharmacology; Colforsin / metabolism; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; Laminin / pharmacology; Stem Cells / cytology; Stem Cells / drug effects; Transforming Growth Factor beta / metabolism; Trophoblasts / cytology; Trophoblasts / metabolism; Culture Media / chemistry; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Gene Expression Regulation, Developmental / drug effects; Cytological Techniques / methods
Sources: Web Of Science, NC State University Libraries
Added: July 3, 2023

2023 journal article

Molecular Engineering of Cyclic Azobenzene‐Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo‐Affinity Chromatography

Advanced Functional Materials, 33(14).

By: R. Prodromou n, B. Moore n, W. Chu n, H. Deal n, A. San Miguel n, A. Brown n, M. Daniele n, V. Pozdin*, S. Menegatti n

author keywords: affinity ligands; azobenzene-peptide hybrids; biomolecular recognition; factor VIII; photo-affinity chromatography
TL;DR: The cyclic azobenzene‐peptide ligands introduced in this report demonstrate a novel route integrating gentle operational conditions in a rapid and efficient bioprocess for the purification of life‐saving biotherapeutics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 20, 2023

2023 article

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function inCaenorhabditis elegans

Clark, A. S., Huayta, J., Morton, K. S., Meyer, J. N., & San-Miguel, A. (2023, August 23).

TL;DR: It is shown that nematodes with dopaminergic dendrite degeneration markers, such as blebbing or breakage, paralyze at higher rates in a dopamine solution, providing evidence that dopamin allergic neurodegeneration morphologies are correlated with functional neuronal outputs. (via Semantic Scholar)
Source: ORCID
Added: February 1, 2024

2023 article

Programming Probiotics: Diet-responsive gene expression and colonization control in engineeredS. boulardii

Durmusoglu, D., Haller, D. J., Al’Abri, I. S., Day, K., Sands, C., Clark, A., … Crook, N. C. (2023, November 17).

TL;DR: Five ligand-responsive gene expression systems were developed and galactose metabolism was repaired in Sb, enabling inducible gene expression in this strain and opening new avenues for precise dosing of therapeutics by Sb via control over its in vivo gene expression levels and localization within the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: November 18, 2023

2022 journal article

Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation

ISCIENCE, 25(11).

TL;DR: It is demonstrated that lifespan mutants can be identified by screening for accelerated protein aggregation through quantitative analysis of fluorescently-labeled aggregates in populations that do not require conditional sterilization or manual separation of parental and progeny populations. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 3, 2023

2021 article

A bioinspired, passive microfluidic lobe filtration system

Clark, A. S., & San-Miguel, A. (2021, August 11). LAB ON A CHIP, Vol. 21.

MeSH headings : Filtration; Microfluidic Analytical Techniques; Microfluidics; Particle Size
TL;DR: Two microfluidic lobe filters bioinspired by the filtration mechanism of two species of manta ray are developed that enable filTration of particles around 10-30 μm with precise control and high throughput by using two arrays of equally spaced filter lobes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 30, 2021

2021 article

Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction

Arulalan, K. S., Huayta, J., Stallrich, J. W., & San-Miguel, A. (2021, March 19).

TL;DR: It is indicated that mixtures drive responses differently than individual components, and that altering environmental conditions, such as increased heat and reduced food availability, result in dramatically different oxidative stress responses mounted by C. elegans. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2021 journal article

Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction

Exposome, 1(1).

Source: ORCID
Added: May 31, 2023

2021 article

Endogenous DAF-16 Spatiotemporal Activity Quantitatively Predicts Lifespan Extension Induced by Dietary Restriction

Huayta, J., & San-Miguel, A. (2021, December 21).

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: May 31, 2023

2021 journal article

Engineering Next Generation Cyclized Peptide Ligands for Light-Controlled Capture and Release of Therapeutic Proteins

ADVANCED FUNCTIONAL MATERIALS, 31(27).

By: R. Prodromou n, K. Day n, S. Saberi-Bosari n, J. Schneible n, M. Mabe n, A. San Miguel n, M. Daniele n, V. Pozdin*, S. Menegatti n

author keywords: azobenzene; cyclized peptide; light‐ controlled biorecognition; microfluidic devices; photochromic switch; photo‐ isomerization kinetics
TL;DR: A framework for prototyping photo‐affinity adsorbents comprising azobenzene‐cyclized peptides (ACPs) conjugated to translucent porous beads (ChemMatrix) and it is demonstrated that the isomerization at different light intensities is correlated to the cyclization geometry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 24, 2021

2021 article

Identifying C. elegans Lifespan Mutants by Screening for Early-Onset Protein Aggregation

Midkiff, D. F., & San-Miguel, A. (2021, December 16).

By: D. Midkiff n & A. San-Miguel n

Source: ORCID
Added: May 31, 2023

2021 journal article

Local velocity of thermoresponsive colloidal gels in rate-driven flow

PHYSICS OF FLUIDS, 33(3).

UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 19, 2021

2021 chapter

Microfluidic devices for imaging and manipulation of C. elegans

In Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms (pp. 295–321).

Source: ORCID
Added: May 31, 2023

2021 article

Optogenetics gets the worm

San-Miguel, A. (2021, June 30). SCIENCE ROBOTICS, Vol. 6.

MeSH headings : Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans Proteins / genetics; Locomotion; Optogenetics
TL;DR: Analysis of Caenorhabditis elegans natural movement and optogenetic control of its muscle cells enable controlled locomotion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 16, 2021

2021 journal article

Two distinct trophectoderm lineage stem cells from human pluripotent stem cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 296.

By: A. Mischler n, V. Karakis n, J. Mahinthakumar n, C. Carberry*, A. San Miguel n, J. Rager*, R. Fry*, B. Rao n

MeSH headings : CDX2 Transcription Factor / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Culture Media; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Female; Humans; Placenta / cytology; Placenta / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Pregnancy; Trophoblasts / cytology; Trophoblasts / metabolism
TL;DR: Derivation of hTSCs and hTESCs from pluripotent stem cells significantly enables construction of models for normal and pathological placental development. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 7, 2021

2020 journal article

A reference map of the human binary protein interactome

Nature, 580(7803), 402–408.

Adriana San Miguel

MeSH headings : Extracellular Space / metabolism; Humans; Organ Specificity; Protein Interaction Mapping; Proteome / metabolism
TL;DR: The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2020 journal article

An inexpensive programmable optogenetic platform for controlled neuronal activation regimens in C. elegans

APL BIOENGINEERING, 4(1).

TL;DR: An accessible platform that enables controlled optogenetic stimulation of Caenorhabditis elegans in two modes, composed of inexpensive components, while providing the illumination strength of high-end systems, which require expensive lasers, shutters, or automated stages is presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science
Added: April 20, 2020

2020 journal article

Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock

BMC BIOLOGY, 18(1).

By: S. Saberi-Bosari n, K. Flores n & A. San-Miguel n

author keywords: Deep learning; Convolutional neural networks; Neurodegeneration; Neuronal beading; Aging; Machine learning; Phenotyping; C; elegans
MeSH headings : Aging / physiology; Animals; Caenorhabditis elegans / physiology; Cold-Shock Response / physiology; Deep Learning; Neurons / physiology; Phenotype
TL;DR: Deep learning is applied to perform quantitative image-based analysis of complex neurodegeneration patterns exhibited by the PVD neuron in C. elegans and revealed that distinct patterns of morphological alteration are induced by aging and cold-shock, suggesting different mechanisms at play. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 26, 2020

2020 article

Deep learning-enabled phenotyping reveals distinct patterns of neurodegeneration induced by aging and cold-shock

Saberi-Bosari, S., Flores, K. B., & San-Miguel, A. (2020, March 9).

By: S. Saberi-Bosari n, K. Flores n & A. San-Miguel n

TL;DR: It is identified that acute cold-shock-induced neurodegeneration is reversible and depends on rearing temperature, and importantly, that aging andcold-shock induce distinct neuronal beading patterns. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2020 article

Genetic and Chemical Effects on Somatic and Germline Aging

Lee, M.-H., Luo, H.-R., Bae, S. H., & San-Miguel, A. (2020, January 4). OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol. 2020.

MeSH headings : Aging / genetics; Animals; Germ Cells; Humans; MicroRNAs / genetics; Mutation / genetics; Reproduction / genetics; Sirtuin 1 / genetics; Sirtuin 1 / metabolism; TRPC Cation Channels / genetics; TRPC Cation Channels / metabolism
TL;DR: Department of Internal Medicine (Division of Hematology/Oncology), Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA Key Laboratory for Aging and Regenerative Medicine, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 27, 2020

2020 article

Lifelong Analysis of Key Aging Genes as Determinants of Lifespan in <it>C</it>. <it>elegans</it>

San Miguel, A., Ramirez, J., & Flores, K. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. San Miguel n, J. Ramirez n & K. Flores n

TL;DR: This work presents a system that enables in vivo tracking the endogenous spatiotemporal activity of key aging genes throughout C. elegans lifespan using an integrative experimental platform based on microfluidics, computer vision, and tagging of endogenous genes via CRISPR/Cas9 genetic engineering approaches. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2019 journal article

Affordable Microfluidic Bead-Sorting Platform for Automated Selection of Porous Particles Functionalized with Bioactive Compounds

SCIENTIFIC REPORTS, 9(1).

By: S. Saberi-Bosari n, M. Omary n, A. Lavoie n, R. Prodromou n, K. Day n, S. Menegatti n, A. San-Miguel n

MeSH headings : Combinatorial Chemistry Techniques / instrumentation; Humans; Image Processing, Computer-Assisted; Immunoglobulin G / chemistry; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques / instrumentation; Peptide Library; Porosity; Proof of Concept Study; Unsupervised Machine Learning
TL;DR: A low-cost microfluidics-based platform enabling automated screening of small porous beads from solid-phase peptide libraries with high sensitivity and specificity, to identify leads with high binding affinity for a biological target is presented. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 28, 2019

2019 article

DERIVATION OF HUMAN TROPHOBLAST STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS

Mischler, A., Karakis, V., San Miguel, A., & Rao, B. (2019, August). PLACENTA, Vol. 83, pp. E59–E59.

By: A. Mischler n, V. Karakis n, A. San Miguel n & B. Rao n

UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2019 journal article

Discovery and Evaluation of Peptide Ligands for Selective Adsorption and Release of Cas9 Nuclease on Solid Substrates

BIOCONJUGATE CHEMISTRY, 30(12), 3057–3068.

By: K. Day n, R. Prodromou n, S. Bosari n, A. Lavoie n, M. Omary n, C. Market n, A. San Miguel n, S. Menegatti n

MeSH headings : Adsorption; Amino Acid Sequence; Binding Sites; CRISPR-Associated Protein 9 / isolation & purification; CRISPR-Associated Protein 9 / metabolism; Drug Discovery; Ligands; Molecular Docking Simulation; Peptide Library; Peptides / metabolism; Resins, Synthetic / chemistry; Substrate Specificity
TL;DR: This work represents the first effort at developing short synthetic Cas9-binding peptides and demonstrates their applicability as affinity ligands for the purification of a Cas nuclease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2020

2019 review

Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans

[Review of ]. MOLECULES, 24(23).

By: D. Midkiff n & A. San-Miguel n

author keywords: screening; microfluidics; phenotyping; genetics; aging
MeSH headings : Animals; Caenorhabditis elegans / genetics; Cell Movement / genetics; High-Throughput Screening Assays; Lab-On-A-Chip Devices; Oligonucleotide Array Sequence Analysis / methods; Protein Transport / genetics
TL;DR: This review of microfluidic technologies that have been used to increase the throughput of genetic and chemical screens in C. elegans will discuss screens for neurobiology, aging, development, behavior, and many other biological processes. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: February 3, 2020

2018 journal article

A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C-elegans

LAB ON A CHIP, 18(20).

By: S. Saberi-Bosari n, J. Huayta n & A. San-Miguel n

MeSH headings : Aging; Animals; Caenorhabditis elegans / cytology; Caenorhabditis elegans / physiology; Equipment Design; Lab-On-A-Chip Devices; Molecular Imaging / instrumentation; Phenotype; Temperature
TL;DR: Computer vision was implemented to perform automated unbiased detection of synapses and quantitative analysis of aging-induced synaptic changes, and was able to perform periodic high-resolution microscopy of fluorescently tagged synapses located at the dorsal side of the nematode's tail throughout the worms' lifespan. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 12, 2018

2016 journal article

Deep phenotyping unveils hidden traits and genetic relations in subtle mutants

NATURE COMMUNICATIONS, 7.

MeSH headings : Alleles; Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Gene Expression Regulation; Gene Regulatory Networks; Microfluidic Analytical Techniques; Models, Genetic; Quantitative Trait Loci
TL;DR: This study describes an automated and unbiased multidimensional phenotyping method that relies on machine learning and complex feature computation of imaging data, and identifies weak alleles affecting synapse morphology in live C. elegans. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 chapter

Microfluidic Platforms for Quantitative Biology Studies in Model Organisms

In C. Lu & S. S. Verbridge (Eds.), Microfluidic Methods for Molecular Biology (pp. 1–18).

By: D. Porto*, T. Rouse*, A. San-Miguel* & H. Lu*

Contributors: D. Porto*, T. Rouse*, A. San-Miguel* & H. Lu*

Ed(s): C. Lu* & S. Verbridge

Event: at Cham

TL;DR: An overview of the current state of the field, the impacts of microfluidics in model organism research, and the outlook, challenges, and opportunities for the future is provided. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2015 journal article

An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies

Lab on a Chip, 15(6), 1497–1507.

By: L. He*, A. Kniss*, A. San-Miguel*, T. Rouse*, M. Kemp* & H. Lu*

Contributors: L. He*, A. Kniss*, A. San-Miguel*, T. Rouse*, M. Kemp* & H. Lu*

MeSH headings : Automation; Calcium Signaling / drug effects; Diffusion; High-Throughput Screening Assays; Humans; Hydrogen Peroxide / pharmacology; Jurkat Cells; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Signal Transduction / drug effects; Single-Cell Analysis / instrumentation; Single-Cell Analysis / methods; Suspensions; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Time Factors
TL;DR: Microfluidic platform for generating dynamic profile of cell stimuli for non-adherent cells and its application in drug discovery and cell reprograming is described. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 11, 2020

2015 journal article

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Cell, 161(3), 647–660.

By: N. Sahni*, S. Yi*, M. Taipale*, J. Fuxman Bass*, J. Coulombe-Huntington*, F. Yang*, J. Peng*, J. Weile* ...

Contributors: N. Sahni*, S. Yi*, M. Taipale*, J. Bass*, J. Coulombe-Huntington*, F. Yang*, J. Peng*, J. Weile* ...

MeSH headings : DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease / genetics; Genome-Wide Association Study; Humans; Mutation, Missense; Open Reading Frames; Protein Folding; Protein Interaction Maps; Protein Stability; Proteins / genetics; Proteins / metabolism
TL;DR: This work functionally profile several thousand missense mutations across a spectrum of Mendelian disorders using various interaction assays, suggesting that disease-associated alleles that perturb distinct protein activities rather than grossly affecting folding and stability are relatively widespread. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2014 journal article

In Vivo Neuron-Wide Analysis of Synaptic Vesicle Precursor Trafficking

Traffic, 15(3), 273–291.

MeSH headings : Animals; Axonal Transport; Caenorhabditis elegans / genetics; Caenorhabditis elegans / metabolism; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Motor Neurons / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Synaptic Vesicles / metabolism
TL;DR: Detailed dissection of speed distributions for wild‐type and unc‐ 104/kif1a mutant animals revealed an unexpected role for UNC‐104/KIF1A in dendritic SVP trafficking, suggesting that polarized SVP transport in concert with local vesicle capturing is necessary for accurate presynapse formation and maintenance. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2013 journal article

A generalized approach for measuring microcapsule permeability with Fluorescence Recovery After Photobleaching

Journal of Materials Science, 48(5), 2215–2223.

By: J. Scrimgeour*, A. San-Miguel*, J. Curtis* & S. Behrens*

Contributors: J. Scrimgeour*, A. San-Miguel*, J. Curtis* & S. Behrens*

TL;DR: The modified approach eliminates the need for painstaking controls to determine the FRAP measurement volume and the spatial distribution of bleached tracers, while accurately extracting the permeability of the microcapsule from FRAP data acquired using a straightforward procedure. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: December 11, 2020

2013 journal article

Microfluidics as a tool for C. elegans research.

WormBook : the Online Review of C. Elegans Biology, 1–19.

Contributors: A. San-Miguel* & H. Lu*

MeSH headings : Animals; Caenorhabditis elegans; Microfluidics / instrumentation; Research Design
TL;DR: This article reviews some of the applications of microfluidics for C. elegans research and provides guides for the design, fabrication, and use ofmicrofluidic devices forC. (via Semantic Scholar)
Source: ORCID
Added: May 31, 2023

2012 journal article

Influence of Nanoscale Particle Roughness on the Stability of Pickering Emulsions

Langmuir, 28(33), 12038–12043.

TL;DR: A surface treatment is developed, applicable to micrometer-sized particles and macroscopic surfaces alike, that produces surface coatings with finely tunable nanoscale roughness and identical surface chemistry that correlated with the stability of emulsions prepared with coated particles of different roughness. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2011 journal article

Correction to “Correlating Aggregation Kinetics and Stationary Diffusion in Protein–Sodium Salt Systems Observed with Dynamic Light Scattering”

Correction to “Correlating Aggregation Kinetics and Stationary Diffusion in Protein–Sodium Salt Systems Observed with Dynamic Light Scattering.” The Journal of Physical Chemistry B, 115(36), 10778–10778.

By: J. Rubin, A. San Miguel*, A. Bommarius & S. Behrens

Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2011 journal article

Permeability control in stimulus-responsive colloidosomes

Soft Matter, 7(5), 1948–1956.

By: A. San Miguel* & S. Behrens*

Contributors: A. Miguel* & S. Behrens*

TL;DR: A novel class of aqueous core colloidosomes that combine the benefit of low capsule permeability (good cargo retention) with the option of a stimulus-triggered fast release in a target environment is presented. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2010 journal article

Correlating Aggregation Kinetics and Stationary Diffusion in Protein−Sodium Salt Systems Observed with Dynamic Light Scattering

The Journal of Physical Chemistry B, 114(12), 4383–4387.

By: J. Rubin*, A. San Miguel*, A. Bommarius* & S. Behrens*

Contributors: J. Rubin*, A. San Miguel*, A. Bommarius* & S. Behrens*

MeSH headings : Kinetics; Light; Proteins / chemistry; Salts / chemistry; Scattering, Radiation
TL;DR: A strong correlation is found in both cases between the ion-specific interaction parameter and the proteins' aggregation tendency as indicated by the salt concentration required for fast aggregation, and the interaction parameter may serve as a predictor of ion- specific aggregation trends. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

2010 journal article

Smart colloidosomes with a dissolution trigger

Soft Matter, 6(14), 3163.

By: A. San Miguel*, J. Scrimgeour*, J. Curtis* & S. Behrens*

Contributors: A. San Miguel*, J. Scrimgeour*, J. Curtis* & S. Behrens*

TL;DR: Measurements of the capsules' permeability are complemented by evidence for fast and complete capsule dissolution in response to a mild pH stimulus. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 28, 2020

Employment

Updated: August 16th, 2023 09:18

2023 - present

North Carolina State University Raleigh, US
Associate Professor Chemical & Biomolecular Engineering

2016 - 2023

NC State University Raleigh, NC, US
Assistant Professor Chemical & Biomolecular Engineering

Education

Updated: December 10th, 2019 16:55

2007 - 2011

Georgia Institute of Technology Atlanta, GA, US
Ph.D. Chemical Engineering Chemical & Biomolecular Engineering

Instituto Tecnológico y de Estudios Superiores de Monterrey Monterrey, MX
BS. Chemical Engineering

Funding History

Funding history based on the linked ORCID record. Updated: October 5th, 2021 22:03

grant August 1, 2021 - July 1, 2025
IMAGiNE: Dissecting Neuronal and Systemic Responses to Interacting Environmental Stressors
National Science Foundation
grant December 15, 2019 - November 30, 2021
EAGER: Rapid evolution of enhancer DNA sequences in Drosophila
Directorate for Biological Sciences
grant January 15, 2019 - December 31, 2020
A platform for in vivo lifelong tracking of aging genes and lifespan prediction under precise environments in C. elegans.
National Institute on Aging
grant August 1, 2018 - July 1, 2020
RoL: FELS: EAGER Rules of lifespan determination and buffering from lifelong spatiotemporal activity of key aging pathways.
National Science Foundation
grant August 15, 2017 - July 31, 2020
A Microfluidics-Enabled In Vitro Model for Early Human Placental Development
National Science Foundation - Directorate for Engineering
grant October 1, 2016 - September 1, 2017
Exploring Synergies Among Neuronal Injury, Neurodegeneration, and Alzheimer's Disease with High-Throughput On-Chip Screening Platforms
Congressionally Directed Medical Research Programs
grant July 1, 2016 - April 30, 2019
Elucidating Synaptic Regulators via High-Throughput Morphology Characterization
National Institute on Aging
grant December 1, 2013 - December 31, 2015
Elucidating Synaptic Regulators via High-Throughput Morphology Characterization
National Institute on Aging
grant
High-Throughput, High-Dimensional (HT-HD) Phenotyping of C. elegans for ALS Drug Discovery
Congressionally Directed Medical Research Programs

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