Adriana San Miguel

Also known as: Adriana San-Miguel; Adriana San Miguel Delgadillo

https://orcid.org/0000-0003-0172-2163

microfluidics, systems biology, quantitative image analysis, phenotyping, neurobiology, aging

Works (44)

Updated: February 1st, 2024 05:17

2024 journal article

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans

NEUROTOXICOLOGY, 100, 100–106.

co-author countries: United States of America 🇺🇸
author keywords: Dopaminergic degeneration; C. elegans; Swimming-induced paralysis; Microfluidics; Quantitative image analysis
Sources: Web Of Science, ORCID
Added: January 22, 2024

2023 journal article

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

PLOS ONE, 18(7).

co-author countries: United States of America 🇺🇸

Ed(s): P. Lajoie

Sources: ORCID, Web Of Science
Added: August 7, 2023

2023 dataset

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

Dryad.

Contributors: A. Miguel, A. Clark, Z. Kalmanson, K. Morton, J. Hartman & J. Meyer

Source: ORCID
Added: February 1, 2024

2023 article

An unbiased, automated platform for scoring dopaminergic neurodegeneration inC. elegans

Clark, A. S., Kalmanson, Z., Morton, K., Hartman, J., Meyer, J., & San-Miguel, A. (2023, February 3).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2023 dataset

Data for: Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

Dryad.

Contributors: J. Huayta, J. Crapster & A. Miguel

Source: ORCID
Added: February 1, 2024

2023 journal article

Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction

COMMUNICATIONS BIOLOGY, 6(1).

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Caenorhabditis elegans / genetics; Longevity / genetics; Caenorhabditis elegans Proteins / metabolism; Signal Transduction; Insulin / metabolism; Forkhead Transcription Factors / metabolism
Sources: Web Of Science, ORCID
Added: March 27, 2023

2023 journal article

Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions

JOURNAL OF BIOLOGICAL CHEMISTRY, 299(5).

By: V. Karakis n, M. Jabeen n, J. Britt n, A. Cordiner n, A. Mischler n, F. Li*, A. Miguel n, B. Rao n

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Cell Differentiation / drug effects; Colforsin / pharmacology; Colforsin / metabolism; HLA-G Antigens / genetics; HLA-G Antigens / metabolism; Laminin / pharmacology; Stem Cells / cytology; Stem Cells / drug effects; Transforming Growth Factor beta / metabolism; Trophoblasts / cytology; Trophoblasts / metabolism; Culture Media / chemistry; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Gene Expression Regulation, Developmental / drug effects; Cytological Techniques / methods
Sources: Web Of Science, ORCID
Added: July 3, 2023

2023 article

Molecular Engineering of Cyclic Azobenzene-Peptide Hybrid Ligands for the Purification of Human Blood Factor VIII via Photo-Affinity Chromatography

Prodromou, R., Moore, B. D., Chu, W., Deal, H., San Miguel, A., Brown, A. C., … Menegatti, S. (2023, January 25). ADVANCED FUNCTIONAL MATERIALS, Vol. 1.

By: R. Prodromou n, B. Moore n, W. Chu n, H. Deal n, A. San Miguel n, A. Brown n, M. Daniele n, V. Pozdin*, S. Menegatti n

co-author countries: United States of America 🇺🇸
author keywords: affinity ligands; azobenzene-peptide hybrids; biomolecular recognition; factor VIII; photo-affinity chromatography
Sources: Web Of Science, ORCID
Added: February 20, 2023

2023 article

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function inCaenorhabditis elegans

Clark, A. S., Huayta, J., Morton, K. S., Meyer, J. N., & San-Miguel, A. (2023, August 23).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: February 1, 2024

2023 article

Programming Probiotics: Diet-responsive gene expression and colonization control in engineeredS. boulardii

Durmusoglu, D., Haller, D. J., Al’Abri, I. S., Day, K., Sands, C., Clark, A., … Crook, N. C. (2023, November 17).

co-author countries: Denmark 🇩🇰 United States of America 🇺🇸
Source: ORCID
Added: November 18, 2023

2022 journal article

Identifying C. elegans lifespan mutants by screening for early-onset protein aggregation

ISCIENCE, 25(11).

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: January 3, 2023

2021 article

A bioinspired, passive microfluidic lobe filtration system

Clark, A. S., & San-Miguel, A. (2021, August 11). LAB ON A CHIP, Vol. 21.

co-author countries: United States of America 🇺🇸
MeSH headings : Filtration; Microfluidic Analytical Techniques; Microfluidics; Particle Size
Sources: Web Of Science, ORCID
Added: August 30, 2021

2021 article

Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction

Arulalan, K. S., Huayta, J., Stallrich, J. W., & San-Miguel, A. (2021, March 19).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2021 journal article

Antagonistic effects of chemical mixtures on the oxidative stress response are silenced by heat stress and reversed under dietary restriction

Exposome, 1(1).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2021 article

Endogenous DAF-16 Spatiotemporal Activity Quantitatively Predicts Lifespan Extension Induced by Dietary Restriction

Huayta, J., & San-Miguel, A. (2021, December 21).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2021 journal article

Engineering Next Generation Cyclized Peptide Ligands for Light-Controlled Capture and Release of Therapeutic Proteins

ADVANCED FUNCTIONAL MATERIALS, 31(27).

By: R. Prodromou n, K. Day n, S. Saberi-Bosari n, J. Schneible n, M. Mabe n, A. San Miguel n, M. Daniele n, V. Pozdin*, S. Menegatti n

co-author countries: United States of America 🇺🇸
author keywords: azobenzene; cyclized peptide; light‐ controlled biorecognition; microfluidic devices; photochromic switch; photo‐ isomerization kinetics
Sources: Web Of Science, ORCID
Added: May 24, 2021

2021 article

Identifying C. elegans Lifespan Mutants by Screening for Early-Onset Protein Aggregation

Midkiff, D. F., & San-Miguel, A. (2021, December 16).

By: D. Midkiff n & A. San-Miguel n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2021 journal article

Local velocity of thermoresponsive colloidal gels in rate-driven flow

PHYSICS OF FLUIDS, 33(3).

By: K. Smith n, A. San-Miguel n & L. Hsiao n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: April 19, 2021

2021 chapter

Microfluidic devices for imaging and manipulation of C. elegans

In Micro and Nano Systems for Biophysical Studies of Cells and Small Organisms (pp. 295–321).

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2021 article

Optogenetics gets the worm

San-Miguel, A. (2021, June 30). SCIENCE ROBOTICS, Vol. 6.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans Proteins / genetics; Locomotion; Optogenetics
Sources: Web Of Science, ORCID
Added: August 16, 2021

2021 journal article

Two distinct trophectoderm lineage stem cells from human pluripotent stem cells

JOURNAL OF BIOLOGICAL CHEMISTRY, 296.

By: A. Mischler n, V. Karakis n, J. Mahinthakumar n, C. Carberry*, A. San Miguel n, J. Rager*, R. Fry*, B. Rao n

co-author countries: United States of America 🇺🇸
MeSH headings : CDX2 Transcription Factor / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Culture Media; Embryonic Stem Cells / cytology; Embryonic Stem Cells / metabolism; Female; Humans; Placenta / cytology; Placenta / metabolism; Pluripotent Stem Cells / cytology; Pluripotent Stem Cells / metabolism; Pregnancy; Trophoblasts / cytology; Trophoblasts / metabolism
Sources: Web Of Science, ORCID
Added: September 7, 2021

2020 journal article

A reference map of the human binary protein interactome

Nature, 580(7803), 402–408.

Adriana San Miguel

MeSH headings : Extracellular Space / metabolism; Humans; Organ Specificity; Protein Interaction Mapping; Proteome / metabolism
Source: ORCID
Added: May 31, 2023

2020 journal article

An inexpensive programmable optogenetic platform for controlled neuronal activation regimens in C. elegans

APL BIOENGINEERING, 4(1).

co-author countries: United States of America 🇺🇸
Sources: ORCID, Web Of Science
Added: April 20, 2020

2020 journal article

Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock

BMC BIOLOGY, 18(1).

By: S. Saberi-Bosari n, K. Flores n & A. San-Miguel n

co-author countries: United States of America 🇺🇸
author keywords: Deep learning; Convolutional neural networks; Neurodegeneration; Neuronal beading; Aging; Machine learning; Phenotyping; C; elegans
MeSH headings : Aging / physiology; Animals; Caenorhabditis elegans / physiology; Cold-Shock Response / physiology; Deep Learning; Neurons / physiology; Phenotype
Sources: Web Of Science, ORCID
Added: October 26, 2020

2020 article

Deep learning-enabled phenotyping reveals distinct patterns of neurodegeneration induced by aging and cold-shock

Saberi-Bosari, S., Flores, K. B., & San-Miguel, A. (2020, March 9).

By: S. Saberi-Bosari n, K. Flores n & A. San-Miguel n

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: May 31, 2023

2020 article

Genetic and Chemical Effects on Somatic and Germline Aging

Lee, M.-H., Luo, H.-R., Bae, S. H., & San-Miguel, A. (2020, January 4). OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, Vol. 2020.

co-author countries: China 🇨🇳 Korea (Republic of) 🇰🇷 United States of America 🇺🇸
MeSH headings : Aging / genetics; Animals; Germ Cells; Humans; MicroRNAs / genetics; Mutation / genetics; Reproduction / genetics; Sirtuin 1 / genetics; Sirtuin 1 / metabolism; TRPC Cation Channels / genetics; TRPC Cation Channels / metabolism
Sources: Web Of Science, ORCID
Added: January 27, 2020

2020 article

Lifelong Analysis of Key Aging Genes as Determinants of Lifespan in C. elegans

San Miguel, A., Ramirez, J., & Flores, K. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. San Miguel n, J. Ramirez n & K. Flores n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: October 12, 2020

2019 journal article

Affordable Microfluidic Bead-Sorting Platform for Automated Selection of Porous Particles Functionalized with Bioactive Compounds

SCIENTIFIC REPORTS, 9(1).

By: S. Saberi-Bosari n, M. Omary n, A. Lavoie n, R. Prodromou n, K. Day n, S. Menegatti n, A. San-Miguel n

co-author countries: United States of America 🇺🇸
MeSH headings : Combinatorial Chemistry Techniques / instrumentation; Humans; Image Processing, Computer-Assisted; Immunoglobulin G / chemistry; Lab-On-A-Chip Devices; Microfluidic Analytical Techniques / instrumentation; Peptide Library; Porosity; Proof of Concept Study; Unsupervised Machine Learning
Sources: Web Of Science, ORCID
Added: May 28, 2019

2019 article

DERIVATION OF HUMAN TROPHOBLAST STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS

Mischler, A., Karakis, V., San Miguel, A., & Rao, B. (2019, August). PLACENTA, Vol. 83, pp. E59–E59.

By: A. Mischler n, V. Karakis n, A. San Miguel n & B. Rao n

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: April 20, 2020

2019 journal article

Discovery and Evaluation of Peptide Ligands for Selective Adsorption and Release of Cas9 Nuclease on Solid Substrates

BIOCONJUGATE CHEMISTRY, 30(12), 3057–3068.

By: K. Day n, R. Prodromou n, S. Bosari n, A. Lavoie n, M. Omary n, C. Market n, A. San Miguel n, S. Menegatti n

co-author countries: United States of America 🇺🇸
MeSH headings : Adsorption; Amino Acid Sequence; Binding Sites; CRISPR-Associated Protein 9 / isolation & purification; CRISPR-Associated Protein 9 / metabolism; Drug Discovery; Ligands; Molecular Docking Simulation; Peptide Library; Peptides / metabolism; Resins, Synthetic / chemistry; Substrate Specificity
Sources: Web Of Science, ORCID
Added: January 13, 2020

2019 review

Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans

[Review of ]. MOLECULES, 24(23).

By: D. Midkiff n & A. San-Miguel n

co-author countries: United States of America 🇺🇸
author keywords: screening; microfluidics; phenotyping; genetics; aging
MeSH headings : Animals; Caenorhabditis elegans / genetics; Cell Movement / genetics; High-Throughput Screening Assays; Lab-On-A-Chip Devices; Oligonucleotide Array Sequence Analysis / methods; Protein Transport / genetics
Sources: ORCID, Web Of Science
Added: February 3, 2020

2018 journal article

A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C-elegans

LAB ON A CHIP, 18(20).

By: S. Saberi-Bosari n, J. Huayta n & A. San-Miguel n

co-author countries: United States of America 🇺🇸
MeSH headings : Aging; Animals; Caenorhabditis elegans / cytology; Caenorhabditis elegans / physiology; Equipment Design; Lab-On-A-Chip Devices; Molecular Imaging / instrumentation; Phenotype; Temperature
Sources: Web Of Science, ORCID
Added: November 12, 2018

2016 journal article

Deep phenotyping unveils hidden traits and genetic relations in subtle mutants

NATURE COMMUNICATIONS, 7.

co-author countries: United States of America 🇺🇸
MeSH headings : Alleles; Animals; Caenorhabditis elegans / genetics; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Gene Expression Regulation; Gene Regulatory Networks; Microfluidic Analytical Techniques; Models, Genetic; Quantitative Trait Loci
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 chapter

Microfluidic Platforms for Quantitative Biology Studies in Model Organisms

In C. Lu & S. S. Verbridge (Eds.), Microfluidic Methods for Molecular Biology (pp. 1–18).

By: D. Porto*, T. Rouse*, A. San-Miguel* & H. Lu*

co-author countries: United States of America 🇺🇸

Contributors: D. Porto*, T. Rouse*, A. San-Miguel* & H. Lu*

Ed(s): C. Lu* & S. Verbridge

Event: at Cham

Source: ORCID
Added: May 31, 2023

2015 journal article

An automated programmable platform enabling multiplex dynamic stimuli delivery and cellular response monitoring for high-throughput suspension single-cell signaling studies

Lab on a Chip, 15(6), 1497–1507.

By: L. He*, A. Kniss*, A. San-Miguel*, T. Rouse*, M. Kemp* & H. Lu*

co-author countries: United States of America 🇺🇸

Contributors: L. He*, A. Kniss*, A. San-Miguel*, T. Rouse*, M. Kemp* & H. Lu*

MeSH headings : Automation; Calcium Signaling / drug effects; Diffusion; High-Throughput Screening Assays; Humans; Hydrogen Peroxide / pharmacology; Jurkat Cells; Microfluidic Analytical Techniques / instrumentation; Microfluidic Analytical Techniques / methods; Signal Transduction / drug effects; Single-Cell Analysis / instrumentation; Single-Cell Analysis / methods; Suspensions; T-Lymphocytes / cytology; T-Lymphocytes / drug effects; Time Factors
Sources: Crossref, ORCID
Added: December 11, 2020

2015 journal article

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Cell, 161(3), 647–660.

co-author countries: Canada 🇨🇦 France 🇫🇷 United States of America 🇺🇸
MeSH headings : DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease / genetics; Genome-Wide Association Study; Humans; Mutation, Missense; Open Reading Frames; Protein Folding; Protein Interaction Maps; Protein Stability; Proteins / genetics; Proteins / metabolism
Sources: Crossref, ORCID
Added: August 28, 2020

2014 journal article

In Vivo Neuron-Wide Analysis of Synaptic Vesicle Precursor Trafficking

Traffic, 15(3), 273–291.

By: C. Maeder*, A. San-Miguel*, E. Wu*, H. Lu* & K. Shen*

co-author countries: United States of America 🇺🇸

Contributors: C. Maeder*, A. San-Miguel*, E. Wu*, H. Lu* & K. Shen*

MeSH headings : Animals; Axonal Transport; Caenorhabditis elegans / genetics; Caenorhabditis elegans / metabolism; Caenorhabditis elegans Proteins / genetics; Caenorhabditis elegans Proteins / metabolism; Motor Neurons / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Synaptic Vesicles / metabolism
Source: ORCID
Added: May 31, 2023

2013 journal article

A generalized approach for measuring microcapsule permeability with Fluorescence Recovery After Photobleaching

Journal of Materials Science, 48(5), 2215–2223.

co-author countries: United States of America 🇺🇸

Contributors: J. Scrimgeour*, A. San-Miguel*, J. Curtis* & S. Behrens*

Sources: Crossref, ORCID
Added: December 11, 2020

2013 journal article

Microfluidics as a tool for C. elegans research.

WormBook : the Online Review of C. Elegans Biology, 1–19.

By: A. San-Miguel & H. Lu

Contributors: A. San-Miguel & H. Lu

MeSH headings : Animals; Caenorhabditis elegans; Microfluidics / instrumentation; Research Design
Source: ORCID
Added: May 31, 2023

2012 journal article

Influence of Nanoscale Particle Roughness on the Stability of Pickering Emulsions

Langmuir, 28(33), 12038–12043.

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Correction to “Correlating Aggregation Kinetics and Stationary Diffusion in Protein–Sodium Salt Systems Observed with Dynamic Light Scattering”

Correction to “Correlating Aggregation Kinetics and Stationary Diffusion in Protein–Sodium Salt Systems Observed with Dynamic Light Scattering.” The Journal of Physical Chemistry B, 115(36), 10778–10778.

By: J. Rubin, A. San Miguel*, A. Bommarius & S. Behrens

Sources: Crossref, ORCID
Added: August 28, 2020

2011 journal article

Permeability control in stimulus-responsive colloidosomes

Soft Matter, 7(5), 1948–1956.

By: A. San Miguel* & S. Behrens*

co-author countries: United States of America 🇺🇸

Contributors: A. Miguel* & S. Behrens*

Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Correlating Aggregation Kinetics and Stationary Diffusion in Protein−Sodium Salt Systems Observed with Dynamic Light Scattering

The Journal of Physical Chemistry B, 114(12), 4383–4387.

By: J. Rubin*, A. San Miguel*, A. Bommarius* & S. Behrens*

co-author countries: United States of America 🇺🇸

Contributors: J. Rubin*, A. San Miguel*, A. Bommarius* & S. Behrens*

MeSH headings : Kinetics; Light; Proteins / chemistry; Salts / chemistry; Scattering, Radiation
Sources: Crossref, ORCID
Added: August 28, 2020

2010 journal article

Smart colloidosomes with a dissolution trigger

Soft Matter, 6(14), 3163.

By: A. San Miguel*, J. Scrimgeour*, J. Curtis* & S. Behrens*

co-author countries: United States of America 🇺🇸

Contributors: A. San Miguel*, J. Scrimgeour*, J. Curtis* & S. Behrens*

Sources: Crossref, ORCID
Added: August 28, 2020

Employment

Updated: August 16th, 2023 09:18

2023 - present

North Carolina State University Raleigh, US
Associate Professor Chemical & Biomolecular Engineering

2016 - 2023

NC State University Raleigh, NC, US
Assistant Professor Chemical & Biomolecular Engineering

Education

Updated: December 10th, 2019 16:55

2007 - 2011

Georgia Institute of Technology Atlanta, GA, US
Ph.D. Chemical Engineering Chemical & Biomolecular Engineering

Instituto Tecnológico y de Estudios Superiores de Monterrey Monterrey, MX
BS. Chemical Engineering

Funding History

Funding history based on the linked ORCID record. Updated: October 5th, 2021 22:03

grant August 1, 2021 - July 1, 2025
IMAGiNE: Dissecting Neuronal and Systemic Responses to Interacting Environmental Stressors
National Science Foundation
grant December 15, 2019 - November 30, 2021
EAGER: Rapid evolution of enhancer DNA sequences in Drosophila
Directorate for Biological Sciences
grant January 15, 2019 - December 31, 2020
A platform for in vivo lifelong tracking of aging genes and lifespan prediction under precise environments in C. elegans.
National Institute on Aging
grant August 1, 2018 - July 1, 2020
RoL: FELS: EAGER Rules of lifespan determination and buffering from lifelong spatiotemporal activity of key aging pathways.
National Science Foundation
grant August 15, 2017 - July 31, 2020
A Microfluidics-Enabled In Vitro Model for Early Human Placental Development
National Science Foundation - Directorate for Engineering
grant October 1, 2016 - September 1, 2017
Exploring Synergies Among Neuronal Injury, Neurodegeneration, and Alzheimer's Disease with High-Throughput On-Chip Screening Platforms
Congressionally Directed Medical Research Programs
grant July 1, 2016 - April 30, 2019
Elucidating Synaptic Regulators via High-Throughput Morphology Characterization
National Institute on Aging
grant December 1, 2013 - December 31, 2015
Elucidating Synaptic Regulators via High-Throughput Morphology Characterization
National Institute on Aging
grant
High-Throughput, High-Dimensional (HT-HD) Phenotyping of C. elegans for ALS Drug Discovery
Congressionally Directed Medical Research Programs

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