Andrew Clark

College of Engineering

Works (4)

Updated: April 24th, 2025 05:32

2024 journal article

A primordial DNA store and compute engine

Nature Nanotechnology, 8.

By: K. Lin n, K. Volkel n, C. Cao n, P. Hook *, R. Polak n , A. Clark n, A. San Miguel n , W. Timp * ...

MeSH headings : DNA / chemistry; DNA / genetics; Cellulose / chemistry; Cellulose / analogs & derivatives; Computers, Molecular
topics (OpenAlex): DNA and Biological Computing; Modular Robots and Swarm Intelligence; Cellular Automata and Applications
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 25, 2024

2023 article

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

Clark, A. S., Kalmanson, Z., Morton, K., Hartman, J., Meyer, J., & San-Miguel, A. (2023, July 7). (P. Lajoie, Ed.). PLoS ONE.

By: A. Clark n, Z. Kalmanson  n, K. Morton *, J. Hartman *, J. Meyer * & A. San-Miguel n 

Ed(s): P. Lajoie

MeSH headings : Animals; Caenorhabditis elegans / physiology; Animals, Genetically Modified; Dopamine; Caenorhabditis elegans Proteins; Oxidopamine; Dopaminergic Neurons / physiology
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms
TL;DR: An automated, unbiased image processing algorithm is developed that can provide comparative insight into how each exposure affects dopaminergic neurodegeneration patterns and validate the accuracy of the algorithm by comparing code-generated, categorical degeneration results with manually scored dendrites of the same experiments. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 7, 2023

2023 article

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans

Clark, A. S., Huayta, J., Morton, K. S., Meyer, J. N., & San-Miguel, A. (2023, December 7). NeuroToxicology, Vol. 100, pp. 100–106.

By: A. Clark n, J. Huayta *, K. Morton *, J. Meyer * & A. San-Miguel n 

author keywords: Dopaminergic degeneration; C. elegans; Swimming-induced paralysis; Microfluidics; Quantitative image analysis
MeSH headings : Animals; Caenorhabditis elegans; Dopamine; Animals, Genetically Modified; Caenorhabditis elegans Proteins; Dopaminergic Neurons; Disease Models, Animal
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Circadian rhythm and melatonin
TL;DR: It is shown that nematodes with dopaminergic dendrite degeneration markers, such as blebbing or breakage, paralyze at higher rates in a dopamine solution, providing evidence that dopaminergic neurodegeneration morphologies are correlated with functional neuronal outputs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2021 article

A bioinspired, passive microfluidic lobe filtration system

Clark, A. S., & San-Miguel, A. (2021, January 1). Lab on a Chip, Vol. 21, pp. 3762–3774.

By: A. Clark n & A. San-Miguel n 

MeSH headings : Filtration; Microfluidic Analytical Techniques; Microfluidics; Particle Size
topics (OpenAlex): Microfluidic and Bio-sensing Technologies; Microfluidic and Capillary Electrophoresis Applications; Electrohydrodynamics and Fluid Dynamics
TL;DR: Two microfluidic lobe filters bioinspired by the filtration mechanism of two species of manta ray are developed that enable filTration of particles around 10-30 μm with precise control and high throughput by using two arrays of equally spaced filter lobes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 30, 2021

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