Andrew Clark

College of Engineering

Works (3)

Updated: January 29th, 2024 07:39

2024 journal article

Morphological hallmarks of dopaminergic neurodegeneration are associated with altered neuron function in Caenorhabditis elegans

NEUROTOXICOLOGY, 100, 100–106.

By: A. Clark n, J. Huayta *, K. Morton *, J. Meyer * & A. San-Miguel  n

author keywords: Dopaminergic degeneration; C. elegans; Swimming-induced paralysis; Microfluidics; Quantitative image analysis
TL;DR: It is shown that nematodes with dopaminergic dendrite degeneration markers, such as blebbing or breakage, paralyze at higher rates in a dopamine solution, providing evidence that dopaminergic neurodegeneration morphologies are correlated with functional neuronal outputs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2023 journal article

An unbiased, automated platform for scoring dopaminergic neurodegeneration in C. elegans

PLOS ONE, 18(7).

By: A. Clark n, Z. Kalmanson  n, K. Morton *, J. Hartman *, J. Meyer * & A. San-Miguel  n

Ed(s): P. Lajoie

TL;DR: An automated, unbiased image processing algorithm is developed that can provide comparative insight into how each exposure affects dopaminergic neurodegeneration patterns and validate the accuracy of the algorithm by comparing code-generated, categorical degeneration results with manually scored dendrites of the same experiments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 7, 2023

2021 article

A bioinspired, passive microfluidic lobe filtration system

Clark, A. S., & San-Miguel, A. (2021, August 11). LAB ON A CHIP, Vol. 21.

By: A. Clark n & A. San-Miguel  n

MeSH headings : Filtration; Microfluidic Analytical Techniques; Microfluidics; Particle Size
TL;DR: Two microfluidic lobe filters bioinspired by the filtration mechanism of two species of manta ray are developed that enable filTration of particles around 10-30 μm with precise control and high throughput by using two arrays of equally spaced filter lobes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 30, 2021

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