@article{mason_papich_schmale_harms_davis_2019, title={Enrofloxacin Pharmacokinetics and Sampling Techniques in California Sea Hares (Aplysia californica)}, volume={58}, ISSN={1559-6109}, url={http://dx.doi.org/10.30802/AALAS-JAALAS-18-000072}, DOI={10.30802/AALAS-JAALAS-18-000072}, abstractNote={This pharmacokinetic study was designed to determine the pharmacokinetics of enrofloxacin at 5 mg/kg when given to sea hares in their hemolymph. Enrofloxacin is a commonly used antimicrobial in veterinary medicine and potentially could be used to treat sea hares exposed to susceptible
 bacterial species. We individually identified 8 juvenile Aplysia californica and group housed them in an open seawater flow system at 14 to 18 °C; 2 served as untreated controls. The remaining 6 animals were injected into the hemocoel with 0.030 mL of 22.7 mg/mL enrofloxacin (average
 dose, 5 to 6 mg/kg). At each time point, 300 μL hemolymph was collected from the pedal hemolymph sinus and HPLC-analyzed for enrofloxacin and ciprofloxacin levels. Enrofloxacin was detected in all dosed animals, at an average peak concentration of 3 μg/mL in hemolymph, and remained in
 the body for 20.3 h with an average clearance of 0.19 μg × h/mL. No ciprofloxacin was detected in any Aplysia in this study. Hemocoel injection appears to be an effective way to administer enrofloxacin to Aplysia and reach clinically relevant concentrations. Enrofloxacin reached therapeutic target concentrations in A. californica when dosed according to the regimen described in the current report.}, number={2}, journal={Journal of the American Association for Laboratory Animal Science}, publisher={American Association for Laboratory Animal Science}, author={Mason, Sharon E and Papich, Mark G and Schmale, Michael C and Harms, Craig A and Davis, Sally A}, year={2019}, month={Mar}, pages={231–234} }
 @article{davis_richter_becker_moyer_sandouk_skinner_taubenberger_2014, title={Characterizing and Diminishing Autofluorescence in Formalin-fixed Paraffin-embedded Human Respiratory Tissue}, volume={62}, ISSN={["1551-5044"]}, DOI={10.1369/0022155414531549}, abstractNote={ Tissue autofluorescence frequently hampers visualization of immunofluorescent markers in formalin-fixed paraffin-embedded respiratory tissues. We assessed nine treatments reported to have efficacy in reducing autofluorescence in other tissue types. The three most efficacious were Eriochrome black T, Sudan black B and sodium borohydride, as measured using white light laser confocal Λ2 (multi-lambda) analysis. We also assessed the impact of steam antigen retrieval and serum application on human tracheal tissue autofluorescence. Functionally fitting this Λ2 data to 2-dimensional Gaussian surfaces revealed that steam antigen retrieval and serum application contribute minimally to autofluorescence and that the three treatments are disparately efficacious. Together, these studies provide a set of guidelines for diminishing autofluorescence in formalin-fixed paraffin-embedded human respiratory tissue. Additionally, these characterization techniques are transferable to similar questions in other tissue types, as demonstrated on frozen human liver tissue and paraffin-embedded mouse lung tissue fixed in different fixatives. }, number={6}, journal={JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY}, author={Davis, A. Sally and Richter, Anke and Becker, Steven and Moyer, Jenna E. and Sandouk, Aline and Skinner, Jeff and Taubenberger, Jeffery K.}, year={2014}, month={Jun}, pages={405–423} }
 @article{anderson_davis_law_lewbart_christian_harms_2010, title={Gross and histologic evaluation of 5 suture materials in the skin and subcutaneous tissue of the california sea hare (Aplysia californica)}, volume={49}, number={1}, journal={Journal of the American Association for Laboratory Animal Science}, author={Anderson, E. T. and Davis, A. S. and Law, J. M. and Lewbart, G. A. and Christian, L. S. and Harms, C. A.}, year={2010}, pages={64–68} }