Anthony T Blikslager

Intestine, tight junction, colic, large animal, horse, pig, physiology, transport, ischemia, injury

Works (363)

Updated: April 4th, 2024 05:22

2023 journal article

A novel case of tracheal injury secondary to gunshot trauma in a white rhinoceros (Ceratotherium simum)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(10).

By: M. Gerard n, A. Blikslager n & H. Marais

author keywords: rhinoceros; tracheal wound; gunshot; poaching; endoscopy
TL;DR: Although more aggressive therapy including surgery may likely be considered in zoo or domestic animals, limited conservative treatment was successful in this wild-managed rhinoceros. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 27, 2023

2023 article

Effects of Prebiotic Galactooligosaccharide (GOS) on Hindgut Microbial Composition of Pigs During the Peri-Weaning Period

Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 187–188.

By: T. Boston n, F. Wang n, L. Xi, S. Kim n, V. Fellner n, M. Scott, A. Ziegler n, L. Van Landeghem n, A. Blikslager n, J. Odle n

author keywords: microbiome; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 article

Effects of Prebiotic Galactooligosaccharide (Gos) on Piglet Growth and Jejunal Morphology During the Peri-Weaning Period

Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, October 28). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 276–277.

By: T. Boston n, F. Wang n, L. Xi, S. Kim n, V. Fellner n, M. Scott, A. Ziegler n, L. Van Landeghem n, A. Blikslager n, J. Odle n

author keywords: intestinal villi; galactooligosaccharides; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023

2023 journal article

Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.

By: K. Rivera n, R. Bilton, J. Burclaff n, M. Czerwinski*, J. Liu*, J. Trueblood*, C. Hinesley*, K. Breau* ...

author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR: A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023

2023 journal article

Retrospective analysis of postoperative complications following surgical treatment of ileal impaction in horses managed with manual decompression compared to jejunal enterotomy

FRONTIERS IN VETERINARY SCIENCE, 10.

By: J. Ruff n, S. Zetterstrom*, L. Boone*, E. Hofmeister*, C. Smith*, K. Epstein*, A. Blikslager n, C. Fogle n, M. Burke n

author keywords: colic; ileum; impaction; enterotomy; manual decompression
TL;DR: It was showed that there were no significant differences in post-operative complications and survival to discharge in horses undergoing distal jejunal enterotomy versus manual decompression for correction of ileal impaction, and pre-operative PCV and duration of surgery were found to be the only predictive factors of survival to discharged. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023

2023 journal article

Risk factors associated with an outbreak of equine coronavirus at a large farm in North Carolina

FRONTIERS IN VETERINARY SCIENCE, 10.

By: K. Hepworth-Warren n, S. Erwin n, C. Moore, J. Talbot, K. Young n, M. Neault*, J. Haugland*, J. Robertson n, A. Blikslager n

author keywords: ECoV; coronavirus; colic; diarrhea; small colon impaction
TL;DR: Clinical findings and risk factors for ECoV infection many of which were associated with intensive management of show horses were described, and clinicians should be aware that clinical signs vary and can include severe colic. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2022 journal article

Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis

FRONTIERS IN ALLERGY, 3.

By: L. Cortes n, D. Brodsky n, C. Chen, T. Pridgen n, J. Odle n, D. Snider n, G. Cruse n, A. Putikova* ...

author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
TL;DR: Swine is established as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics and it is demonstrated that the sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EiE. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023

2022 article

Mechanisms and modeling of wound repair in the intestinal epithelium

Boger, K. D., Sheridan, A. E., Ziegler, A. L., & Blikslager, A. T. (2022, June 13). TISSUE BARRIERS, Vol. 6.

By: K. Boger n, A. Sheridan n, A. Ziegler n & A. Blikslager n

author keywords: IPEC-J2 cells; transepithelial electrical resistance; injury barrier function; cell model
MeSH headings : Humans; Caco-2 Cells; Intestinal Mucosa / metabolism; Intestines; Ischemia
TL;DR: This review focuses on in vitro injury models and intestinal cell lines utilized in such systems and the use of intestine cell lines, IPEC-J2, Caco-2, T-84, HT-29, and IEC-6, to model intestinal epithelium. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2022

2022 journal article

Multi-Institutional Retrospective Case-Control Study Evaluating Clinical Outcomes of Foals with Small Intestinal Strangulating Obstruction: 2000-2020

ANIMALS, 12(11).

By: S. Erwin n, M. Clark n, J. Dechant*, M. Aitken*, D. Hassel*, A. Blikslager n, A. Ziegler n

author keywords: horse; colic; foal; ischemia; small intestinal strangulating obstruction; surgery
TL;DR: Unexpectedly, short-term survival tended to be higher in foals than adults and may have been partly driven by case selection prior to referral or surgery or decision-making intraoperatively, and more optimism toward surgical treatment of foals with suspected SISO may be warranted. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 28, 2022

2022 article

Non-steroidal anti-inflammatory drugs in equine orthopaedics

Jacobs, C. C., Schnabel, L. V., McIlwraith, C. W., & Blikslager, A. T. (2022, February 10). EQUINE VETERINARY JOURNAL, Vol. 2.

By: C. Jacobs n, L. Schnabel n, C. McIlwraith* & A. Blikslager n

author keywords: horse; non-steroidal anti-inflammatory drug; orthopaedics; osteoarthritis
TL;DR: This review aims to summarise the current literature on the use of NSAIDs for equine orthopaedic disorders and examines new and future avenues for the management of inflammation in equine Orthopaedics. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 28, 2022

2022 review

Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 9.

By: E. Rose n, A. Blikslager n & A. Ziegler n

author keywords: intestinal microbiota; translational models; pig models; gut commensals; gastrointestinal disease
TL;DR: To further elucidate the pathogenesis of these disease syndromes as well as uncover novel therapies and preventative measures, gastrointestinal researchers should consider the pig as a powerful, translational model of the gastrointestinal microbiota. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022

2021 journal article

Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic

ANIMALS, 11(12).

By: S. Erwin n, A. Blikslager n & A. Ziegler n

author keywords: horse; colic; ischemia-reperfusion injury; intestinal barrier repair; enteric nervous system; enteric glial cells; tight junction proteins
TL;DR: The current understanding of the roles of the gut microbiome, nutrition, stress, and the ENS in maturation of intestinal repair mechanisms after foaling is reviewed and how this may influence age-dependent outcomes in equine colic cases is reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 25, 2021

2021 journal article

In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model

PLOS ONE, 16(4).

By: H. Enomoto n, J. Yeatts n, L. Carbajal n, B. Krishnan, J. Madan, S. Laumas, A. Blikslager n, K. Messenger n

MeSH headings : Administration, Oral; Animals; Celiac Disease / drug therapy; Drug Liberation; Duodenum / metabolism; Jejunum / metabolism; Oligopeptides / administration & dosage; Oligopeptides / pharmacokinetics; Oligopeptides / therapeutic use; Swine
TL;DR: The data shows that LA is available in detectable concentrations at the site of CeD, with a sensitive liquid chromatography/tandem mass spectrometry method developed to quantify LA concentrations in porcine intestinal fluid samples. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 journal article

Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions

PLOS ONE, 16(4).

By: Z. Slifer n, L. Hernandez n, T. Pridgen n, A. Carlson n, K. Messenger n, J. Madan, B. Krishnan, S. Laumas, A. Blikslager n

MeSH headings : Animals; Disease Models, Animal; Female; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Ischemia / drug therapy; Ischemia / metabolism; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Male; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability / drug effects; Swine; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: It is concluded that LA stimulates repair of ischemic-injured epithelium at the level of the tight junctions, at an optimal dose of 1 μM LA. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 review

Larazotide acetate: a pharmacological peptide approach to tight junction regulation

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 320(6), G983–G989.

By: Z. Slifer n, B. Krishnan, J. Madan & A. Blikslager n

author keywords: barrier function; celiac disease; tight junction
MeSH headings : Animals; Celiac Disease / drug therapy; Celiac Disease / metabolism; Humans; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: Small and large animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021

2021 review

Postoperative Ileus: Comparative Pathophysiology and Future Therapies

[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 8.

By: E. Hellstrom n, A. Ziegler n & A. Blikslager n

author keywords: intestine; equine; surgery; barrier function; enteric glia and neurons; microbiota
TL;DR: Understanding of the roles of the gastrointestinal microbiota, intestinal barrier function, the post-surgical inflammatory response, as well as enteric glial cells, a component of the enteric nervous system, in modulating postoperative gastrointestinal motility and the pathogenesis of POI may provide future targets for prevention and/or therapy ofPOI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2021

2021 journal article

Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

International Journal of Molecular Sciences, 22(13), 6729.

By: E. Rose n, J. Odle n, A. Blikslager n & A. Ziegler n

author keywords: probiotics; prebiotics; bioactive compounds; intestinal barrier function; tight junctions; toll-like receptors; intestinal microbiota
MeSH headings : Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Humans; Infant; Intestinal Mucosa / cytology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Prebiotics; Probiotics / pharmacology; Tight Junction Proteins / metabolism; Tight Junctions / metabolism; Toll-Like Receptors / metabolism
TL;DR: Current views on the effects of pro- and prebiotics on the intestinal epithelial barrier as well as on non-epithelial cell barrier constituents, such as the enteric glial cell network are summarized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 24, 2021

2021 journal article

Steroid Eluting Esophageal-Targeted Drug Delivery Devices for Treatment of Eosinophilic Esophagitis

POLYMERS, 13(4).

By: A. Prasher n, R. Shrivastava n, D. Dahl n, P. Sharma-Huynh*, P. Maturavongsadit n, T. Pridgen n, A. Schorzman*, W. Zamboni* ...

author keywords: eosinophilic esophagitis (EoE); esophageal drug delivery systems; drug-eluting string; 3D printing; photopolymerizable resins; Drug loading strategies; steroids; fluticasone
TL;DR: Two novel esophageal-specific drug delivery platforms are reported, including a fluticasone-eluting string that could be swallowed similar to the string test “entero-test” and used for overnight treatment, and a 3D printed ring for local and sustained release of flutic asone in the esophagus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 18, 2021

2021 journal article

Trends in the management of horses referred for evaluation of colic: 2004-2017

Equine Veterinary Education.

By: A. Blikslager n & T. Mair*

author keywords: horse; colic
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2020

2021 journal article

Ultrasound findings in tendons and ligaments of lame sport horses competing or training in South Florida venues during the winter seasons of 2007 through 2016

EQUINE VETERINARY EDUCATION, 33(6), 306–309.

By: R. Mitchell*, D. DaSilva*, C. Rosenbaum, A. Blikslager n & R. Edwards*

author keywords: horse; sport horse; lameness; ultrasonography; suspensory ligament; inferior check ligament; superficial and deep digital flexor tendons
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2020 article

A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia

Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. Sheridan*, T. Pridgen*, J. Odle*, L. Van Landeghem*, A. Blikslager* & A. Ziegler*

TL;DR: It is hypothesized that EGC inhibition in juveniles will block epithelial barrier repair after ischemic injury mimicking the neonatal phenotype, and the development of glial‐epithelial crosstalk in barrier repair will ultimately guide novel clinical solutions to improve outcomes in neonatal patients affected by intestinal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020

2020 article

Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair

Ziegler, A., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. Ziegler n & A. Blikslager n

TL;DR: The results indicate that acute transport stress on the day of experimental intestinal injury modeling may increase mucosal susceptibility to epithelial loss, but also prime the tissue for a more robust barrier repair response. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 article

Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model

Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: L. Shapiro n, A. Ziegler n, J. Odle n, L. Van Landeghem n & A. Blikslager n

TL;DR: Test the effects of dietary oligosaccharides on postnatal changes in the EGC network and intestinal morphology in a neonatal pig model to find increased mucosal expression of EGC markers earlier in postnatal development in the high oligOSaccharide group, as well as histological changes consistent with enhanced rates of gut maturation in pigs fed a high oligosACcharide diet. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020

2020 journal article

Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model

TISSUE BARRIERS, 8(4).

By: A. Ziegler n, T. Pridgen n & A. Blikslager n

author keywords: Intestinal barrier; ischemia; stress; pig model; tight junctions
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / physiopathology; Ischemia / physiopathology; Permeability; Swine
TL;DR: The effects of a period of environmental acclimation versus acute transport stress on mucosal barrier repair after intestinal ischemic injury and recovery are reported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 27, 2020

2020 personal communication

Letter to the Editor: Post-operative reflux - a surgeon's perspective

Blikslager, A. T. (2020, January).

By: A. Blikslager n

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 1, 2021

2020 journal article

Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 318(4), G613–G623.

By: L. Kruger n, T. Pridgen n, E. Taylor n, K. Garman* & A. Blikslager n

author keywords: ClC-2; esophagus; injury; lubiprostone; repair
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Bumetanide / pharmacology; Chloride Channel Agonists / pharmacology; Chloride Channels / genetics; Chloride Channels / metabolism; Chlorides / pharmacology; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Dose-Response Relationship, Drug; Esophageal Mucosa / drug effects; Female; Gene Expression Regulation / drug effects; Hydrochloric Acid / pharmacology; Lubiprostone / pharmacology; Male; Occludin / metabolism; Swine; Time Factors; Zinc Compounds / pharmacology
TL;DR: It is concluded that ClC-2 contributes to esophageal protection from acid exposure, potentially offering a new therapeutic target. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2020 chapter

Surgical disorders of the large intestine

In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th edition). St. Louis, MO: Elsevier.

By: J. Marshall & A. Blikslager

Ed(s): B. Smith, D. Van Metre & N. Pusterla

Source: NC State University Libraries
Added: October 18, 2020

2020 chapter

Surgical disorders of the small intestine

In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th edition). St. Louis: Elsevier.

By: A. Blikslager & J. Marshall

Ed(s): B. Smith, D. Van Metre & N. Pusterla

Source: NC State University Libraries
Added: October 18, 2020

2020 journal article

The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium

International Journal of Molecular Sciences.

By: Z. Slifer n & A. Blikslager n

author keywords: barrier function; tight junction; repair; occludin; claudin; NHE2; ClC-2
MeSH headings : Animals; Humans; Intestinal Diseases / metabolism; Intestinal Diseases / pathology; Intestinal Diseases / prevention & control; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Tight Junction Proteins / metabolism
TL;DR: This review provides an overview of the tight junction complex components and how they link to other plasmalemmal proteins, such as ion channels and transporters, to induce tight junction closure during repair of acute injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: February 6, 2020

2020 journal article

The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases

International Journal of Molecular Sciences.

By: Y. Jin* & A. Blikslager n

author keywords: myosin light chain kinase; rho-associated coiled-coil containing protein kinase; apical junction complex; tight junction; adherens junction
MeSH headings : Animals; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Myosin-Light-Chain Kinase / metabolism; Myosin-Light-Chain Kinase / physiology; Permeability; Tight Junctions / metabolism; rho-Associated Kinases / metabolism; rho-Associated Kinases / physiology
TL;DR: The current state of knowledge regarding the role of MLCK- and ROCK-mediated pathways in the regulation of the intestinal barrier during normal homeostasis and digestive diseases is summarized. (via Semantic Scholar)
Source: ORCID
Added: May 23, 2020

2020 article

iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model

Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: S. Erwin n, M. Touvron*, J. Odle n, L. Van Landeghem n, A. Blikslager n & A. Ziegler n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020

2019 chapter

Colic

In Equine Surgery (pp. 521–528).

By: J. Marshall & A. Blikslager*

TL;DR: Colic is abdominal pain normally caused by a gastrointestinal disorder; however, horses may also exhibit signs of colic with non-intestinal disorders (e.g. shipping fever, ruptured bladder, rupturing uterine artery in mares). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2019 review

Colic Prevention to Avoid Colic Surgery: A Surgeon's Perspective

[Review of ]. JOURNAL OF EQUINE VETERINARY SCIENCE, 76, 1–5.

By: A. Blikslager n

author keywords: Forage; Impaction; Volvulus; Lipoma
MeSH headings : Animals; Colic / veterinary; Colonic Diseases / veterinary; Horse Diseases; Horses; Humans; Male; Surgeons
TL;DR: Understanding management risk factors can lead to recommendations that prevent colic in horses, and additional study of these factors may ultimately lead to reductions in the prevalence of colic by suggesting optimal management practices. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019

2019 journal article

Disease features of equine coronavirus and enteric salmonellosis are similar in horses

Journal of Veterinary Internal Medicine, 33(2), 912–917.

By: A. Manship n, A. Blikslager n & J. Elfenbein n

author keywords: colic; equine coronavirus; fever; salmonella
MeSH headings : Animals; Betacoronavirus 1 / isolation & purification; Blood Cell Count / veterinary; Blood Chemical Analysis / veterinary; Communicable Diseases, Emerging; Coronavirus Infections / diagnosis; Coronavirus Infections / veterinary; Diagnosis, Differential; Feces / microbiology; Female; Horse Diseases / diagnosis; Horse Diseases / microbiology; Horses; Male; Retrospective Studies; Salmonella / isolation & purification; Salmonella Infections, Animal / diagnosis
TL;DR: Equine coronavirus and Salmonella infections share clinical features, suggesting both diseases should be differential diagnoses for horses with fever and enteric clinical signs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: April 22, 2019

2019 journal article

Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?

Equine Veterinary Journal, 51(3), 423–423.

By: A. Ziegler n, C. Fogle n, M. Burke n & A. Blikslager n

MeSH headings : 4-Butyrolactone / analogs & derivatives; Animals; Clonixin / analogs & derivatives; Horses; Sulfones
TL;DR: It is proposed that validating a trend towards improved survival in horses treated with firocoxib would require additional studies with greater numbers of horses and likely modification of the study design to include preoperative drug randomisation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: May 6, 2019

2019 journal article

Preservation of reserve intestinal epithelial stem cells following severe ischemic injury

American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(4), G482–G494.

By: L. Gonzalez n, A. Stewart n, J. Freund n, C. Kucera n, C. Dekaney n, S. Magness n, A. Blikslager n

author keywords: intestine; ischemia reperfusion injury; large animal model; reserve stem cells; stem cell
MeSH headings : Animals; Apoptosis; Cell Proliferation / physiology; Cell Self Renewal / physiology; Cell Survival / physiology; Disease Models, Animal; Homeodomain Proteins / metabolism; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ischemia / metabolism; Receptors, G-Protein-Coupled / metabolism; Reperfusion Injury / metabolism; Swine
TL;DR: Data indicate that Hopx+ cells are resistant to injury and are the likely source of epithelial renewal following prolonged ischemic injury, and it is therefore possible that targeting reserve stem cells will lead to new therapies for patients with severe intestinal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: March 16, 2019

2019 chapter

Principles of Intestinal Injury and Determination of Intestinal Viability

In Equine Surgery (pp. 529–536).

By: V. Cook, A. Blikslager* & J. Marshall

TL;DR: Intestinal injury, although typically associated with ischemic lesions, occurs during any obstructive intestinal disease to varying degrees depending on the type of obstruction and the extent of vascular compromise. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2019 chapter

Stomach and Duodenum

In Equine Surgery (pp. 496–505).

By: A. Blikslager* & D. Wilson

TL;DR: These reviews are intended to update practitioners and researchers regarding recent developments in gastroduodenal physiology and pathophysiology as well as management of gastroduODenal disorders. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 5, 2019

2019 chapter

Transverse and Small Colon

In Equine Surgery (pp. 621–631).

By: T. Prange, A. Blikslager* & P. Rakestraw

Sources: Crossref, NC State University Libraries
Added: December 5, 2019

2018 journal article

138 - Knockout of CLC-2 Reveals Critical Functions of Adherens Junctions in Colonic Homeostasis and Tumorigenicity

Gastroenterology, 154(6), S-37-S-38.

By: Y. Jin & A. Blikslager*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2018 journal article

Advances in Diagnostics and Treatments in Horses with Acute Colic and Postoperative Ileus

Veterinary Clinics of North America: Equine Practice, 34(1), 81–96.

By: M. Burke n & A. Blikslager n

author keywords: Acute colic; Novel diagnostic biomarkers; Systemic inflammatory response syndrome (SIRS); Pain and motility management
MeSH headings : Acute Disease; Animals; Colic / diagnosis; Colic / surgery; Colic / therapy; Colic / veterinary; Horse Diseases / diagnosis; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Ileus; Postoperative Complications / etiology; Postoperative Complications / veterinary
TL;DR: Investigation of novel biomarkers, which may help to differentiate surgical lesions from those that can be managed medically, continues to be an active area of research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

An update on equine post-operative ileus: Definitions, pathophysiology and management

Equine Veterinary Journal, 50(3), 292–303.

By: Z. Lisowski*, R. Pirie*, A. Blikslager n, D. Lefebvre*, D. Hume* & N. Hudson*

author keywords: horse; colic; surgery; POI; abdomen; gastrointestinal motility
MeSH headings : Animals; Horse Diseases / etiology; Horse Diseases / physiopathology; Horse Diseases / therapy; Horses; Ileus / etiology; Ileus / physiopathology; Ileus / veterinary; Intestinal Pseudo-Obstruction / etiology; Intestinal Pseudo-Obstruction / physiopathology; Intestinal Pseudo-Obstruction / veterinary; Postoperative Complications / physiopathology; Postoperative Complications / therapy; Postoperative Complications / veterinary; Risk Factors
TL;DR: Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2018 journal article

Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs

Journal of Veterinary Internal Medicine, 32(2), 670–678.

By: T. Hill*, B. Lascelles n & A. Blikslager n

author keywords: barrier function; stress ulcer; transepithelial electrical resistance; Ussing chamber
MeSH headings : Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Hydrogen-Ion Concentration; In Vitro Techniques; Isotonic Solutions; Ringer's Solution; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Sucralfate / administration & dosage; Sucralfate / pharmacology
TL;DR: Sorbitfate appeared effective at restoring defects in gastric barrier function induced by acid and accelerating repair of tissues subjected to acid in this model, suggesting that sucralfate could have utility for the treatment and prevention of SRMD in dogs. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2018 journal article

Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair

PLOS ONE, 13(8), e0200674.

By: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Contributors: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Ed(s): J. Karhausen

MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR: Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 16, 2018

2018 journal article

Equine Intestinal Mucosal Pathobiology

Annual Review of Animal Biosciences, 6(1), 157–175.

By: A. Blikslager n & L. Gonzalez n

author keywords: horse; intestine; ischemia; barrier function; stem cell niche; enteroid
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Colic / complications; Colic / pathology; Colic / veterinary; Horse Diseases / pathology; Horses; Inflammation / drug therapy; Inflammation / veterinary; Intestinal Mucosa / pathology; Intestinal Obstruction / veterinary; Ischemia / pathology; Ischemia / veterinary; Regeneration; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR: Mechanisms of repair, including villus contraction, epithelial restitution, and tight junction closure, are critical to reforming the mucosal barrier and completion of mucosal regeneration requires proliferation, which is now being actively studied in equine enteroids. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2018 journal article

Equine intestinal mucosal pathobiology

Annual Review of Animal Biosciences, Vol 6, 6, 157–175.

By: A. Blikslager & L. Gonzalez

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Evaluation of digital cryotherapy using a commercially available sleeve style ice boot in healthy horses and horses receiving i.v. endotoxin

EQUINE VETERINARY JOURNAL, 50(6), 848–853.

By: M. Burke n, J. Tomlinson*, A. Blikslager n, A. Johnson* & B. Dallap-Schaer*

author keywords: horse; digital cryotherapy; sepsis-associated laminitis; sleeve-style ice boot; lamellar temperatures
MeSH headings : Animals; Cross-Over Studies; Cryotherapy / instrumentation; Cryotherapy / standards; Cryotherapy / veterinary; Endotoxins / administration & dosage; Endotoxins / blood; Female; Foot Diseases / therapy; Foot Diseases / veterinary; Forelimb; Hoof and Claw / pathology; Horse Diseases / therapy; Horses; Male; Prospective Studies; Random Allocation; Skin Temperature
TL;DR: This study is the first to show that a sleeve style boot, where ice does not cover the hoof, can cause significant decreases in lamellar temperatures through cooling of blood as it travels to the foot. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018

2018 journal article

IDENTIFICATION OF A NASOCONCHAL PARANASAL SINUS IN THE WHITE RHINOCEROS (CERATOTHERIUM SIMUM)

JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 444–449.

By: M. Gerard*, Z. Glyphis, C. Crawford, A. Blikslager* & J. Marais

author keywords: Anatomy; Ceratotherium simum; nasal sinus; nasocon
MeSH headings : Animals; Cadaver; Craniocerebral Trauma / diagnostic imaging; Craniocerebral Trauma / veterinary; Female; Head / diagnostic imaging; Horns / injuries; Paranasal Sinuses / diagnostic imaging; Perissodactyla / anatomy & histology; Tomography, X-Ray Computed / veterinary; Veterinary Medicine / methods
TL;DR: The anatomy of the most commonly injured area of the head of the white rhinoceros, the nasoconchal sinus, was identified and confirmed to be readily exposed by horn removal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia

Journal of Visualized Experiments, 5(135).

By: A. Stieler Stewart n, J. Freund n, A. Blikslager n & L. Gonzalez n

author keywords: Medicine; Issue 135; Porcine; intestine; ischemia-reperfusion; stem cell; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / methods; Disease Models, Animal; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Intestine, Small / pathology; Ischemia / etiology; Mice; Stem Cells / metabolism; Swine
TL;DR: By utilizing a porcine model, a protocol is established in which segmental loops of intestinal ischemia can be created within a single animal, enabling the study of differing time points of ischemic injury and repair in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 16, 2018

2018 journal article

Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity

American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G966–G979.

By: Y. Jin n, D. Ibrahim n, S. Magness n & A. Blikslager n

author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
TL;DR: Disruption of adherens junctions in the absence of chloride channel protein-2 revealed critical functions of these junctional structures, including maintenance of colonic homeostasis and differentiation as well as driving tumorigenicity by regulating β-catenin signaling. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 31, 2018

2018 journal article

Mo1169 - Role of Cftr and Clc-2 in Esophageal Barrier Function

Gastroenterology, 154(6), S-694.

By: L. Kruger, T. Pridgen, K. Garman & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2018 journal article

Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction

Equine Veterinary Journal, 51(3), 329–335.

By: A. Ziegler n, C. Freeman n, C. Fogle n, M. Burke n, J. Davis*, V. Cook*, L. Southwood*, A. Blikslager n

author keywords: horse; colic; endotoxaemia; flunixin meglumine; firocoxib; clinical study
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Obstruction / complications; Intestinal Obstruction / veterinary; Male; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Random Allocation; Sulfones / administration & dosage; Sulfones / therapeutic use
TL;DR: Treatment of post-surgical SISO horses with firocoxib (COX-2 selective) would reduce the signs of endotoxaemia to a greater extent than flunixin meglumine (nonselective COX inhibitor) while continuing to provide similar levels of pain control. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: May 6, 2019

2018 journal article

Sa1183 - Larazotide Stimulates Recovery of Ischemic-Injured Intestine in a Dose-Dependent Manner Associated with Restoration of Tight Junctions

Gastroenterology, 154(6), S-270.

By: L. Hernandez, A. Carlson, T. Pridgen, K. Messenger, C. Prior, S. Laumas, J. Madan, B. Krishnan, A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2018 journal article

Su2039 - Larazotide Stimulates Recovery of Ischemic-Injured Intestine in the Presence of the Non-Steroidal Anti-Inflammatory Drug (NSAID) Indomethacin Related to Recovery of Tight Junctions

Gastroenterology, 154(6), S-1365.

By: L. Hernandez, A. Carlson, T. Pridgen, K. Messenger, C. Prior, S. Laumas, J. Madan, B. Krishnan, A. Blikslager*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2017 journal article

A Novel Inflammation-Activated Drug Delivery System Using Self-Assembling Hydrogel Doubles Esophageal Dwell Time in an Esophageal Injury Porcine Model

Gastroenterology, 152(5), S859–S860.

By: E. Dellon, N. Joshi, A. Blikslager*, L. Gonzalez*, T. Pridgen, A. Whitlow, M. Ivanovic, K. Slaughter ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2017 journal article

Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair

American Journal of Physiology-Gastrointestinal and Liver Physiology, 313(3), G180–G191.

By: L. Krüger n, L. Gonzalez n, T. Pridgen n, S. McCall*, R. Furstenberg*, I. Harnden*, G. Carnighan n, A. Cox n ...

author keywords: esophagus; injury; repair; esophageal submucosal gland; proliferation
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Proliferation / physiology; Esophageal Diseases / pathology; Esophagus / cytology; Esophagus / injuries; Female; Gene Expression Regulation / physiology; Humans; Male; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Staining and Labeling; Swine
TL;DR: A novel porcine model of injury and repair using radiofrequency ablation has been developed, allowing for reproducible injury to the esophagus to study repair in an animal model with esophageal submucosal glands, a key anatomical feature and missing in rodent models but possibly harboring progenitor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Exploring Product Solution Differences Due to Choice Model Selection in the Presence of Noncompensatory Decisions With Conjunctive Screening Rules

JOURNAL OF MECHANICAL DESIGN, 139(2).

By: J. Shin n & S. Ferguson n

TL;DR: It is demonstrated how respondents making noncompensatory choices with conjunctive rules can lead to compensatory model estimations with distinct respondent segmentation and relative, large absolute part-worth values. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Feasibility and safety of lumbosacral epiduroscopy in the standing horse

EQUINE VETERINARY JOURNAL, 49(3), 322–328.

By: B. Shrauner n, A. Blikslager n, J. Davis n, N. Campbell n, M. Law n, M. Lustgarten n, T. Prange n

Contributors: B. Shrauner n, A. Blikslager n, J. Davis n, N. Campbell n, M. Law n, M. Lustgarten n, T. Prange n

author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / surgery; Female; Horse Diseases / surgery; Horses; Lumbosacral Region / surgery; Male
TL;DR: Lumbosacral epiduroscopy can be performed safely in sedated standing horses and may become a valuable diagnostic tool in horses with caudal back or hindlimb pain of unknown origin. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress

Neurogastroenterology & Motility, 29(11), e13216.

By: A. Ziegler n & A. Blikslager n

author keywords: early life adversity; intestinal barrier function; irritable bowel syndrome; porcine models
MeSH headings : Animals; Disease Models, Animal; Gastrointestinal Diseases / etiology; Gastrointestinal Diseases / physiopathology; Humans; Recurrence; Stress, Psychological / complications; Sus scrofa; Translational Research, Biomedical
TL;DR: New insights are highlighted from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders and the roles of gender and hypomaturity in gastrointestinal responses to stress. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019

2017 chapter

Pathophysiology of Gastrointestinal Obstruction and Strangulation

In The Equine Acute Abdomen (pp. 102–118).

By: A. Blikslager n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2017 journal article

Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation

Cellular and Molecular Gastroenterology and Hepatology, 4(3), 385–404.

By: R. von Furstenberg*, J. Li*, C. Stolarchuk*, R. Feder*, A. Campbell*, L. Kruger n, L. Gonzalez n, A. Blikslager n ...

author keywords: Esophagus; Barrett's Esophagus; 3D Culture; Acinar Ductal Metaplasia; Adult Stem Cell
TL;DR: The results suggest that the activated ESMG state, seen in both human disease and the authors' porcine model, may provide a source of cells to repopulate damaged epithelium in a normal manner (squamous) or abnormally (columnar epithelia). (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019

2017 journal article

Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus

Equine Veterinary Journal, 50(4), 452–456.

By: C. Kucera n, L. Stranahan n, F. Hughes*, A. Blikslager n & L. Gonzalez n

author keywords: horse; large colon volvulus; immunohistochemistry; phospho-histone H3; intestine; stem cell
MeSH headings : Animals; Biomarkers; Cell Proliferation / physiology; Cohort Studies; Colonic Diseases / veterinary; Female; Gene Expression Regulation; Horse Diseases / blood; Horses; Intestinal Volvulus / metabolism; Intestinal Volvulus / pathology; Intestinal Volvulus / veterinary; Male; ROC Curve; Retrospective Studies; Survival Analysis
TL;DR: PHH3 immunohistochemical analysis may assist in more accurate prediction of survival to hospital discharge of LCV cases and biomarkers PCNA, SOX9 and Ki-67 did not predict short-term survival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 personal communication

Reply to Dr Freeman: Keep your surgical options open

Blikslager, A. T. (2017, July).

By: A. Blikslager n

UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 chapter

Small Intestinal Function

In The Equine Acute Abdomen (pp. 27–40).

By: A. Blikslager n

Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2017 journal article

Supplementation of Maternal Diets with Docosahexaenoic Acid and Methylating Vitamins Impacts Growth and Development of Fetuses from Malnourished Gilts

Current Developments in Nutrition, 2(3).

By: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, J. Sommer n, W. Flowers n, A. Blikslager n, L. Gonzalez n, J. Odle n

Contributors: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, J. Sommer n, W. Flowers n, A. Blikslager n, L. Gonzalez n, J. Odle n

author keywords: choline; B-vitamins; epigenetics; intrauterine growth restriction; nutrient restriction; low birth weight
TL;DR: Despite the mobilization of maternal stores, malnourished litters displayed reduced brain development that was fully mitigated by micronutrient supplementation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2017 book

The Equine Acute Abdomen

(A. T. Blikslager, N. A. White II, J. N. Moore, & T. S. Mair, Eds.).

By: N. Libraries

Ed(s): A. Blikslager, N. White, J. Moore & T. Mair

TL;DR: Providing coverage of the diseases producing equine acute abdomen or colic, this text covers diagnosis, treatment, anaesthesia, surgery and intensive care. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019

2017 journal article

Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 Signaling

Journal of Virology, 92(4), JVI.01677–01617.

By: Q. Zhang*, H. Ke*, A. Blikslager n, T. Fujita* & D. Yoo*

author keywords: porcine epidemic diarrhea virus; PEDV; enteric coronaviruses; type III interferons; IRF1; peroxisomes; innate immune evasion; IFN lambda; nsp1
MeSH headings : Animals; Chlorocebus aethiops; Coronavirus Infections / virology; Epithelial Cells / virology; Host-Pathogen Interactions; Immune Evasion; Interferon Regulatory Factor-1 / metabolism; Interferons / immunology; Male; Mutation; Peroxisomes / immunology; Porcine epidemic diarrhea virus / pathogenicity; Porcine epidemic diarrhea virus / physiology; Signal Transduction; Swine / virology; Vero Cells; Viral Proteins / metabolism
TL;DR: PEDV evasion of the type III IFN response in intestinal epithelial cells is shown for the first time, and it provides valuable information on host cell-virus interactions not only for PEDV but also for other enteric viral infections in swine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

Update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses

Journal of the American Veterinary Medical Association, 250(11), 1271–1274.

By: A. Ziegler*, C. Fogle* & A. Blikslager*

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Drug Compounding; Horse Diseases / drug therapy; Horses; Species Specificity; Sulfones / administration & dosage; Sulfones / therapeutic use; Veterinary Drugs
TL;DR: Understanding the nuances of firocoxib administration, including the importance of correct dosing and the contraindications of combining NSAIDs, and knowledge of the potential advantages of COX-2 selectivity will help veterinarians select and treat patients that could benefit from this new class of NSAID. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS

Reproduction, Fertility and Development, 28(2), 143.

By: S. Simpson n, L. Gonzalez n, J. Chung n, A. Blikslager n, S. Magness n & J. Piedrahita n

TL;DR: The generation of a porcine stem cell reporter line using the combination of transcription activator-like effector nucleases and somatic cell NT, which represents significant progress toward the study of adult stem cells, their progenitors, and the stem cell niche, using a large animal model with an anatomy, physiology, and ability to recapitulate human disease that overcomes the current limitations of rodent models. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2016 journal article

784 Neonates Have a Reduced Ability to Repair Jejunal Mucosal Injury As Compared to Juveniles in a Pig Model of Ischemia/ Reperfusion Injury

Gastroenterology, 150(4), S163.

By: A. Ziegler, T. Pridgen, G. Carnighan, J. Odle* & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2016 journal article

Comparison of lipopolysaccharides and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses

Equine Veterinary Journal, 49(2), 155–159.

By: J. Fogle n, M. Jacob n, A. Blikslager n, A. Edwards n, B. Wagner*, K. Dean n, C. Fogle n

Contributors: J. Fogle n, M. Jacob n, A. Blikslager n, A. Edwards n, B. Wagner*, K. Dean n, C. Fogle n

author keywords: horse; soluble CD14; endotoxin; sepsis; inflammation; colic
MeSH headings : Animals; Biomarkers / blood; Endotoxemia / blood; Endotoxemia / veterinary; Horse Diseases / blood; Horse Diseases / diagnosis; Horses; Lipopolysaccharide Receptors / blood; Lipopolysaccharides
TL;DR: It is suggested that sCD14 and LPS were poor predictors of clinical endotoxaemia for the horses in this study, and further investigation is warranted to assess the utility of s CD14 measurement as a clinically useful biomarker to identify endotox aemia in horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Effect of topically applied Saccharomyces boulardii on the healing of acute porcine wounds: A preliminary study

BMC Research Notes, 9(1).

By: J. Partlow, A. Blikslager n, C. Matthews, M. Law n, J. Daniels*, R. Baker*, R. Labens*

Contributors: J. Partlow, A. Blikslager n, C. Matthews, M. Law n, J. Daniels*, R. Baker*, R. Labens*

MeSH headings : Acute Disease; Analysis of Variance; Animals; Female; Host-Pathogen Interactions; Male; Pilot Projects; Prospective Studies; Saccharomyces boulardii / physiology; Skin / injuries; Skin / microbiology; Skin / physiopathology; Surface Properties; Swine; Time Factors; Wound Healing / physiology; Wounds and Injuries / microbiology; Wounds and Injuries / physiopathology
TL;DR: Topical application of Saccharomyces boulardii does not hasten wound healing or change the wounds’ microbiome under the conditions reported in this study. (via Semantic Scholar)
Source: ORCID
Added: September 3, 2019

2016 journal article

Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy

EQUINE VETERINARY JOURNAL, 48(1), 125–129.

By: T. Prange n, B. Shrauner n & A. Blikslager n

Contributors: T. Prange n, B. Shrauner n & A. Blikslager n

author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Cadaver; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / anatomy & histology; Horses / anatomy & histology; Lumbosacral Region / anatomy & histology
TL;DR: Lumbosacral epiduroscopy is technically feasible in standing horses and may become a valuable diagnostic tool in horses with caudal back or limb pain of unknown origin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 personal communication

Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy Response

Prange, T., Shrauner, B. D., & Blikslager, A. T. (2016, January).

By: T. Prange*, B. Shrauner* & A. Blikslager*

Contributors: T. Prange*, B. Shrauner* & A. Blikslager*

MeSH headings : Animals; Endoscopy; Horses; Lumbar Vertebrae; Lumbosacral Region; Spinal Canal
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells

Tissue Barriers, 4(3), e1187325.

By: M. Thakre-Nighot n & A. Blikslager n

author keywords: JNK; MKN-28; occludin; p38 MAPK; tight junction
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Capillary Permeability; Cell Line, Tumor; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Humans; Indomethacin / pharmacology; Mice; Mice, Inbred C57BL; Occludin / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: Data suggests that indomethacin compromises the gastric epithelial barrier via p38 MAPK inducing occludin alterations in the TJs, and Pretreatment with the p38MAPK inhibitor significantly attenuated the disruption of barrier function. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Intestinal Ischemia–Reperfusion: Rooting for the SOCS?

Digestive Diseases and Sciences, 62(1), 4–6.

By: Y. Jin n & A. Blikslager n

MeSH headings : Humans; Intestinal Mucosa; Intestines; Ischemia; Reperfusion; Reperfusion Injury
TL;DR: It is reported that ischemic preconditioning-induced suppressor of cytokine signaling-1 (SOCS-1) activation protects the intestine from IR injury via downregulation of the Toll-like receptor 4 (TLR4) pathway. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019

2016 journal article

Large Animal Models: The Key to Translational Discovery in Digestive Disease Research

Cellular and Molecular Gastroenterology and Hepatology, 2(6), 716–724.

By: A. Ziegler n, L. Gonzalez n & A. Blikslager n

author keywords: Pig; Ischemia/Reperfusion Injury; Mucosal Repair; Tight Junction
TL;DR: Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access, and cellular tools are providing the methodology to translate basic science findings using in-depth mechanistic analyses, holding great promise for the future of clinically relevant digestive disease research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019

2016 journal article

Mo1253 Ductular and Proliferative Response of Esophageal Submucosal Glands in a Porcine Model of Esophageal Injury and Repair

Gastroenterology, 150(4), S679–S680.

By: L. Kruger, L. Gonzalez*, R. von Furstenberg, S. Henning, A. Blikslager* & K. Garman

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2016 journal article

Mo1298 Critical Contribution of Intestinal Stem Cells in the Repair of Ischemia Reperfusion Injury

Gastroenterology, 150(4), S691.

By: A. Stewart, J. Freund, S. Magness, P. Lund, A. Blikslager* & L. Gonzalez*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2016 journal article

Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury

American Journal of Physiology-Cell Physiology, 311(6), C996–C1004.

By: Y. Jin n & A. Blikslager n

author keywords: intestinal anoxia/reoxygenation injury; tight junctions; myosin light chain kinase; Caco-2BBe1; intestinal barrier functions
MeSH headings : Animals; Caco-2 Cells; Cell Line, Tumor; Dextrans / metabolism; Endocytosis / physiology; Epithelial Cells / metabolism; Epithelial Cells / physiology; Humans; Hypoxia / metabolism; Hypoxia / physiopathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Myosin Light Chains / metabolism; Myosin-Light-Chain Kinase / metabolism; Occludin / metabolism; Permeability; Phosphorylation / physiology; Signal Transduction / physiology; Swine; Tight Junctions / metabolism; Tight Junctions / physiology
TL;DR: It is suggested that MLCK-induced occludin endocytosis mediates intestinal epithelial barrier dysfunction during A/R injury and may be a target for the therapeutic treatment of ischemia/reperfusion injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2016 journal article

Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo

MBio, 7(6).

By: V. Meliopoulos*, S. Marvin*, P. Freiden*, L. Moser*, P. Nighot n, R. Ali n, A. Blikslager n, M. Reddivari* ...

MeSH headings : Administration, Oral; Avastrovirus / pathogenicity; Capsid Proteins / administration & dosage; Capsid Proteins / toxicity; Cell Membrane / chemistry; Cytoplasm / chemistry; Diarrhea / chemically induced; Diarrhea / pathology; Intestinal Mucosa / pathology; Sodium-Hydrogen Exchangers / analysis; Turkey
TL;DR: Oral administration of purified recombinant turkey astrovirus 2 (TAstV-2) structural (capsid) protein induces acute diarrhea, increases barrier permeability, and causes relocalization of NHE3 in the small intestine, suggesting that rotavirus may not be alone in possessing enterotoxigenic activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018

2016 conference paper

Parametric study of a fluidic artificial muscle actuated electrohydraulic system

Proceedings of the asme conference on smart materials adaptive.

Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2016 article

The paradox of diarrhoeal disease and small colon obstruction

Blikslager, A. T. (2016, August). EQUINE VETERINARY EDUCATION, Vol. 28, pp. 424–425.

By: A. Blikslager n

Contributors: A. Blikslager n

author keywords: horse; colic; ulcerative colitis; fibrosis; stricture; impaction
TL;DR: The interesting finding of stenosis in a case series of 3 foals that initially presented with diarrhoeal disease is suggestive of an inflammatory and fibrotic event that is more frequently reported in people with inflammatory bowel disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research

American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(2), G63–G75.

By: L. Gonzalez n, A. Moeser n & A. Blikslager n

Contributors: L. Gonzalez n, A. Moeser n & A. Blikslager n

author keywords: animal model; intestine; ischemia; mucosal injury; reperfusion
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / injuries; Intestines / pathology; Ischemia / complications; Ischemia / pathology; Oxygen / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Reperfusion Injury / pathology; Translational Research, Biomedical / methods
TL;DR: This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Characterization of discrete equine intestinal epithelial cell lineages

American Journal of Veterinary Research, 76(4), 358–366.

By: L. Gonzalez*, L. Kinnin & A. Blikslager*

Contributors: L. Gonzalez*, L. Kinnin & A. Blikslager*

MeSH headings : Animals; Cell Lineage; Colic / pathology; Colic / veterinary; Epithelial Cells / cytology; Female; Horse Diseases / pathology; Horses; Intestinal Mucosa / cytology
TL;DR: The methodology used can enhance detection of stem cells and progenitor cells as well as postmitotic cell lineages in equine intestinal tissues and may have relevance to regenerative potential of intestinal mucosa and survival in horses with colic. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target

Tissue Barriers, 3(4), e1105906.

By: Y. Jin n & A. Blikslager n

Contributors: Y. Jin n & A. Blikslager n

author keywords: ClC-2 chloride channel; gastrointestinal diseases; intestinal barrier function; lubiprostone; tight junctions
TL;DR: The role of ClC-2 in intestinal barrier function during intestinal disorders, including experimental ischemia/reperfusion injury and dextran sodium sulfate (DSS)-induced inflammatory bowel disease is detailed. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 18, 2019

2015 journal article

Clinical features and management of equine post operative ileus (POI): Survey of Diplomates of the American Colleges of Veterinary Internal Medicine (ACVIM), Veterinary Surgeons (ACVS) and Veterinary Emergency and Critical Care (ACVECC)

Equine Veterinary Journal, 48(6), 714–719.

By: D. Lefebvre*, N. Hudson*, Y. Elce*, A. Blikslager n, T. Divers*, I. Handel*, W. Tremaine*, R. Pirie*

Contributors: D. Lefebvre*, N. Hudson*, Y. Elce*, A. Blikslager n, T. Divers*, I. Handel*, W. Tremaine*, R. Pirie*

author keywords: horse; ileus; colic; lidocaine; intestine
MeSH headings : Animals; Colic / surgery; Colic / veterinary; Cross-Sectional Studies; Data Collection; Horse Diseases / diagnosis; Horse Diseases / etiology; Horses; Intestinal Pseudo-Obstruction / etiology; Intestinal Pseudo-Obstruction / therapy; Intestinal Pseudo-Obstruction / veterinary; Intestine, Small / pathology; Postoperative Complications / diagnosis; Postoperative Complications / therapy; Postoperative Complications / veterinary; Surveys and Questionnaires; United States; Veterinarians
TL;DR: It was concluded that further comparative analysis of opinions, canvassed from additional colleges of equine veterinary specialism worldwide, would provide valuable additional insight into current POI knowledge on a more global scale. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Gastric impaction and large colon volvulus: Can one lead to the other?

Blikslager, A. T. (2015, September). EQUINE VETERINARY EDUCATION, Vol. 27, pp. 460–461.

By: A. Blikslager n

Contributors: A. Blikslager n

author keywords: horse; colic; gastric impaction; large colon volvulus; microbiota
TL;DR: The possibility of stomach impaction resulting in large colon volvulus is raised by authors reporting the findings of both lesions in 7 horses, and it is interesting to speculate on the possible roles of gas accumulation or other changes in the intracolonic environment, such as composition in microbiota. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion

PLOS ONE, 10(9), e0138174.

By: M. Nighot n, P. Nighot n, T. Ma*, D. Malinowska*, G. Shull*, J. Cuppoletti*, A. Blikslager n

Contributors: M. Nighot n, P. Nighot n, T. Ma*, D. Malinowska*, G. Shull*, J. Cuppoletti*, A. Blikslager n

Ed(s): A. Guerrero-Hernandez

MeSH headings : Animals; Biological Transport; CLC-2 Chloride Channels; Cell Count; Chloride Channels / genetics; Cytoplasmic Vesicles / metabolism; Digestion / genetics; Digestion / physiology; Fluorescent Antibody Technique; Gastric Acid / metabolism; H(+)-K(+)-Exchanging ATPase / biosynthesis; H(+)-K(+)-Exchanging ATPase / metabolism; Mice; Mice, Knockout; Microscopy, Electron; Parietal Cells, Gastric / metabolism; Parietal Cells, Gastric / ultrastructure; Pepsinogen A / metabolism
TL;DR: Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase, reduced tubulovesicles and reduced stimulated acid secretion. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis

Inflammatory Bowel Diseases, 21(12), 2747–2757.

By: Y. Jin n, T. Pridgen n & A. Blikslager n

Contributors: Y. Jin n, T. Pridgen n & A. Blikslager n

author keywords: ClC-2 chloride channel; lubiprostone; tight junctions; inflammatory bowel diseases; intestinal barrier function
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Chloride Channel Agonists / pharmacology; Chloride Channels / deficiency; Chloride Channels / drug effects; Colitis / chemically induced; Colitis / drug therapy; Colitis / genetics; Dextran Sulfate; Fluorescent Antibody Technique; Intestinal Mucosa / metabolism; Intestines / drug effects; Lubiprostone / pharmacology; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Permeability / drug effects; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; Trinitrobenzenes
TL;DR: A central role for ClC-2 in restoration of barrier function and tight junction architecture in experimental murine colitis is suggested, which can be therapeutically targeted with lubiprostone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Porcine models of digestive disease: the future of large animal translational research

Translational Research, 166(1), 12–27.

By: L. Gonzalez n, A. Moeser n & A. Blikslager n

Contributors: L. Gonzalez n, A. Moeser n & A. Blikslager n

MeSH headings : Animals; Animals, Genetically Modified; Digestive System Diseases / etiology; Digestive System Diseases / physiopathology; Disease Models, Animal; Enterocolitis, Necrotizing / etiology; Gastrointestinal Tract / anatomy & histology; Gastrointestinal Tract / blood supply; Gastrointestinal Tract / injuries; Humans; Intestines / transplantation; Reperfusion Injury / etiology; Short Bowel Syndrome / etiology; Short Bowel Syndrome / therapy; Species Specificity; Stress, Psychological / complications; Swine; Translational Research, Biomedical; Wound Healing
TL;DR: This review assesses currently used porcine models of gastrointestinal physiology and disease and provides a rationale for the use of these models for future translational studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018

2015 chapter

Surgical disorders of the large intestine

In B. P. Smith (Ed.), Large Animal Internal Medicine (5th edition, pp. 715–718). St. Louis, MO: Elsevier.

By: J. Marshall & A. Blikslager

Ed(s): B. Smith

Source: NC State University Libraries
Added: October 18, 2020

2015 chapter

Surgical disorders of the small intestine

In B. P. Smith (Ed.), Large Animal Internal Medicine (5th edition, pp. 703–707). St. Louis, MO: Elsevier.

By: A. Blikslager & J. Marshall

Ed(s): B. Smith

Source: NC State University Libraries
Added: October 18, 2020

2014 journal article

Bovine immunoglobulin protein isolates for the nutritional management of enteropathy

World Journal of Gastroenterology, 20(33), 11713.

By: B. Petschow n, A. Blikslager, E. Weaver, J. Campbell, J. Polo, A. Shaw, B. Burnett, G. Klein, J. Rhoads

Contributors: B. Petschow n, A. Blikslager, E. Weaver, J. Campbell, J. Polo, A. Shaw, B. Burnett, G. Klein, J. Rhoads

author keywords: Immunoglobulins; Plasma proteins; Inflammation; Gut barrier; Diarrhea; Malabsorption; Treatment; Nutrition
MeSH headings : Administration, Oral; Animals; Dietary Proteins / administration & dosage; Dietary Proteins / adverse effects; Humans; Immunoglobulins / administration & dosage; Immunoglobulins / adverse effects; Inflammation Mediators / metabolism; Intestinal Absorption; Intestinal Diseases / diagnosis; Intestinal Diseases / immunology; Intestinal Diseases / metabolism; Intestinal Diseases / microbiology; Intestinal Diseases / physiopathology; Intestinal Diseases / therapy; Intestinal Mucosa / metabolism; Intestines / immunology; Intestines / microbiology; Intestines / physiopathology; Microbiota; Nutritional Status; Nutritional Support / adverse effects; Nutritional Support / methods; Permeability; Treatment Outcome
TL;DR: Preclinical and clinical studies with plasma/serum protein concentrates supported the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 3, 2019

2014 journal article

Mo1960 Intestinal Epithelial Cells Expressing Biomarkers of Crypt Base Columnar or Reserve Stem Cells Show Differential Resistance to Ischemia-Reperfusion Injury

Gastroenterology, 146(5), S-702.

By: L. Gonzalez*, S. Magness, P. Lund & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2014 journal article

Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013

Equine Veterinary Journal, 47(3), 279–284.

By: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

Contributors: L. Gonzalez n, C. Fogle n, W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, A. Blikslager n

author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR: Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 249–256.

By: B. Holland n, C. Fogle n, A. Blikslager n, A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

Contributors: B. Holland n, C. Fogle n, A. Blikslager n, A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n

MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / blood; 4-Butyrolactone / pharmacokinetics; 4-Butyrolactone / pharmacology; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cross-Over Studies; Dinoprostone / blood; Horses / metabolism; Injections, Intravenous / veterinary; Ointments; Sulfones / administration & dosage; Sulfones / blood; Sulfones / pharmacokinetics; Sulfones / pharmacology; Tablets; Thromboxane B2 / blood
TL;DR: This study indicates a lack of bioequivalence between the oral formulations of firocoxib when administered as a single dose to healthy horses, as well as a higher Cmax, shorter Tmax, and greater AUC for the paste compared to the tablet. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Su1947 Genetic Absence of Chloride Channel CLC-2 Results in Disruption of Organization and Function of Murine Gastric Glands

Gastroenterology, 146(5), S-505-S-506.

By: M. Nighot, P. Nighot, T. Ma & A. Blikslager*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020

2014 journal article

The Effect of Tramadol and Indomethacin Coadministration on Gastric Barrier Function in Dogs

Journal of Veterinary Internal Medicine, 28(3), 793–798.

By: T. Hill*, B. Lascelles n, J. M. Law & A. Blikslager n

Contributors: T. Hill*, B. Lascelles n, J. Law n & A. Blikslager n

author keywords: NSAID; tramadol; ulcer
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Dinoprostone / analysis; Dogs; Drug Therapy, Combination; Gastric Mucosa / chemistry; Gastric Mucosa / drug effects; Gastric Mucosa / physiology; Indomethacin / administration & dosage; Indomethacin / pharmacology; Thromboxane B2 / analysis; Tramadol / administration & dosage; Tramadol / pharmacology
TL;DR: The results suggest that if there is an adverse interaction of the 2 drugs in vivo, it is unlikely to be via prostanoid inhibition, and could be via nonselective cyclooxygenase inhibition. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2014 journal article

The use of nonsteroidal anti-inflammatory drugs in critically ill horses

Journal of Veterinary Emergency and Critical Care, 25(1), 76–88.

By: V. Cook* & A. Blikslager n

Contributors: V. Cook* & A. Blikslager n

author keywords: analgesia; antiendotoxin; drug therapy; equine; side-effects
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Critical Care; Critical Illness; Cyclooxygenase 2 / administration & dosage; Cyclooxygenase 2 / adverse effects; Cyclooxygenase 2 / therapeutic use; Gastrointestinal Tract / drug effects; Horse Diseases / drug therapy; Horses; Humans; Kidney / drug effects; Pain / drug therapy; Pain / veterinary; Veterinary Medicine
TL;DR: The physiology of the cyclooxygenase (COX) enzymes with reference to the beneficial effects of nonsteroidal anti-inflammatory drugs related to their analgesic and antiendotoxic properties as well as the mechanisms responsible for adverse gastrointestinal, renal, and coagulation effects are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Tu2028 Lubiprostone reduces murine colitis principally in a ClC-2-dependent manner.

Gastroenterology, 146(5), S-901.

By: Y. Jin*, T. Pridgen & A. Blikslager*

Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019

2013 journal article

Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets

World Journal of Gastroenterology, 19(31), 5094–5102.

By: S. Jacobi n, A. Moeser, A. Blikslager, J. Rhoads, B. Corl, R. Harrell, J. Odle

Contributors: S. Jacobi n, A. Moeser, A. Blikslager, J. Rhoads, B. Corl, R. Harrell, J. Odle

author keywords: Rotavirus gastroenteritis; Kwashiorkor; Occludin; Ussing chamber; Villus
MeSH headings : Animals; Animals, Newborn; Diarrhea / metabolism; Diarrhea / virology; Disease Models, Animal; Electric Impedance; Humans; Infant Formula / metabolism; Infant, Newborn; Intestinal Absorption; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Mannitol / metabolism; Occludin / metabolism; Permeability; Protein-Energy Malnutrition / metabolism; Protein-Energy Malnutrition / pathology; Protein-Energy Malnutrition / virology; Rotavirus Infections / metabolism; Rotavirus Infections / pathology; Rotavirus Infections / virology; Swine; Tight Junctions / metabolism; Tight Junctions / virology; Time Factors; Weight Loss
TL;DR: Overall, malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration

PLoS ONE, 8(6), e66465.

By: L. Gonzalez n, I. Williamson*, J. Piedrahita n, A. Blikslager n & S. Magness*

Contributors: L. Gonzalez n, I. Williamson*, J. Piedrahita n, A. Blikslager n & S. Magness*

Ed(s): S. Singh

MeSH headings : Animals; Apoptosis; Biomarkers / metabolism; Cell Culture Techniques; Cell Cycle; Cell Differentiation; Cell Lineage; Cell Proliferation; Cells, Cultured; Epithelial Cells / physiology; Epithelial Cells / ultrastructure; Goblet Cells / physiology; Goblet Cells / ultrastructure; Intestinal Mucosa / physiology; Intestinal Mucosa / ultrastructure; Regeneration; Stem Cells / physiology; Sus scrofa
TL;DR: Biomarker characterization and development of IESC culture in the porcine model represents a foundation for translational studies of I ESC-driven regeneration of the intestinal epithelium in physiology and disease. (via Semantic Scholar)
Sources: Crossref, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2013 journal article

Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis

Inflammatory Bowel Diseases, 19(13), 2867–2877.

By: P. Nighot n, K. Young n, M. Nighot n, M. Rawat*, E. Sung n, N. Maharshak*, S. Plevy*, T. Ma*, A. Blikslager n

Contributors: P. Nighot n, K. Young n, M. Nighot n, M. Rawat*, E. Sung n, N. Maharshak*, S. Plevy*, T. Ma*, A. Blikslager n

author keywords: inflammatory bowel disease; barrier function; tight junction
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Caco-2 Cells; Chloride Channels / physiology; Colitis / chemically induced; Colitis / metabolism; Colitis / pathology; Cytokines / metabolism; Dextran Sulfate / toxicity; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions / metabolism; Tight Junctions / pathology
TL;DR: ClC-2 plays a critical role in experimental colitis in that its absence increases disease activity, reduces barrier function and recovery, and perturbs TJs. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Ex vivo effect of gold nanoparticles on porcine synovial membrane

Tissue Barriers, 1(2), e24314.

By: R. Labens n, B. Lascelles n, A. Charlton n, N. Ferrero n, A. Van Wettere n, X. Xia n, A. Blikslager n

author keywords: gold; nanoparticles; nanogold; synovium; permeability; synovitis; arthritis; ussing; ex vivo
TL;DR: Results with ex vivo tissue modeling of porcine synovium support an anti-inflammatory effect of AuNPs warranting further investigation, and exposure to pro-inflammatory factors did not significantly affect AuNP permeation or biomarker levels in this model. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019

2013 journal article

Feeding intravenously saves the patient but starves the gut: consequences for the intestinal barrier

The Journal of Physiology, 591(15), 3673–3673.

By: A. Blikslager n

Contributors: A. Blikslager n

MeSH headings : Animals; Intestinal Mucosa / physiopathology; Male; Parenteral Nutrition, Total / adverse effects; Receptors, Tumor Necrosis Factor, Type I / physiology; Receptors, Tumor Necrosis Factor, Type II / physiology; Tumor Necrosis Factor-alpha / physiology
TL;DR: Feng & Teitelbaum (2013) have built on their previous findings of barrier disruption in experimental animals on TPN by showing that a complex interplay of tumour necrosis factor (TNFα) and its two receptors (TNFR1 and TNFR2) is responsible for the breakdown of intestinal epithelial tight junctions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2013 book

Gastroduodenal Ulceration

In Small Animal Soft Tissue Surgery (pp. 329–340).

By: T. Hill, B. Lascelles & A. Blikslager*

Contributors: T. Hill, B. Lascelles & A. Blikslager*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: January 22, 2019

2013 journal article

Su1099 A Translational Porcine Model of Intestinal Stem Cells

Gastroenterology, 144(5), S-398.

By: L. Gonzalez*, A. Blikslager*, J. Piedrahita* & S. Magness

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020

2013 journal article

Tu1641 Effects of Lubiprostone in a Porcine Model of Stress-Induced Intestinal Barrier Injury

Gastroenterology, 144(5), S-812-S-813.

By: M. Nighot, P. Nighot, K. Young, L. Edwards, A. Blikslager* & A. Moeser

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2013 journal article

Validation of a photogrammetric technique for computing equine hoof volume

VETERINARY JOURNAL, 197(3), 625–630.

By: R. Labens n, W. Redding n, K. Desai n, K. Orde, R. Mansmann n & A. Blikslager n

Contributors: R. Labens n, W. Redding n, K. Desai n, K. Vom Orde, R. Mansmann n & A. Blikslager n

author keywords: Equine; Foot volume; Finite element analysis; Photogrammetry
MeSH headings : Animals; Hoof and Claw / anatomy & histology; Horses / anatomy & histology; Image Processing, Computer-Assisted / methods; Photogrammetry / methods; Photogrammetry / veterinary
TL;DR: Pre-trim photogrammetric measurements showed excellent precision and accuracy and the results did not depend on the person acquiring the images, but average differences in foot volume after trimming are likely too small to be detected with confidence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

211 Chloride Channel CLC-2 Mediated Tight Junction Barrier Function Modulates DSS-Induced Murine Colitis

Gastroenterology, 142(5), S-52.

By: P. Nighot, K. Young & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2012 journal article

Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection

Comparative Immunology, Microbiology and Infectious Diseases, 35(1), 63–69.

By: R. Meyerhoff n, P. Nighot n, R. Ali n, A. Blikslager n & M. Koci n

Contributors: R. Meyerhoff n, P. Nighot n, R. Ali n, A. Blikslager n & M. Koci n

author keywords: Astrovirus; Enterocyte; Turkey; Inducible nitric oxide; Innate immunity
MeSH headings : Amino Acid Sequence; Animals; Astroviridae Infections / enzymology; Astroviridae Infections / veterinary; Astroviridae Infections / virology; Avastrovirus / physiology; Avian Proteins / genetics; Avian Proteins / metabolism; Bird Diseases / enzymology; Bird Diseases / virology; Enterocytes / enzymology; Enterocytes / pathology; Enterocytes / virology; Gene Expression; HEK293 Cells; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Lentivirus / genetics; Molecular Sequence Data; Nitric Oxide / biosynthesis; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phylogeny; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Transfection; Turkeys
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin

American Journal of Physiology-Cell Physiology, 302(1), C178–C187.

By: P. Nighot n & A. Blikslager n

Contributors: P. Nighot n & A. Blikslager n

author keywords: Caco-2; epithelium; intestine; permeability
MeSH headings : CLC-2 Chloride Channels; Caco-2 Cells; Caveolae / metabolism; Caveolae / physiology; Cell Communication / physiology; Chloride Channels / metabolism; Chloride Channels / physiology; Humans; Intracellular Fluid / metabolism; Intracellular Fluid / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Occludin; Protein Transport / physiology; Tight Junctions / metabolism; Tight Junctions / physiology
TL;DR: Data indicate that ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of the tight junction protein occludin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 book

Colic: Diagnosis, Surgical Decision, and Preoperative Management

In Equine Surgery (pp. 402–407).

By: J. Marshall & A. Blikslager*

Contributors: J. Marshall & A. Blikslager*

Source: ORCID
Added: September 3, 2019

2012 journal article

Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors

BMC Pharmacology, 12(1).

By: J. Cuppoletti*, A. Blikslager n, J. Chakrabarti*, P. Nighot n & D. Malinowska*

Contributors: J. Cuppoletti*, A. Blikslager n, J. Chakrabarti*, P. Nighot n & D. Malinowska*

MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Animals; Calcium / physiology; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Epithelial Cells / drug effects; Epithelial Cells / physiology; Female; Gastrointestinal Agents / pharmacology; Homeostasis / drug effects; Humans; In Vitro Techniques; Interferon-gamma / pharmacology; Ischemia / physiopathology; Jejunum / drug effects; Jejunum / physiology; Lubiprostone; Male; Membrane Potentials / drug effects; Occludin / metabolism; Peptides / pharmacology; Swine; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The finding that lubiprostone, but not active linaclotide, exhibits the additional distinct property of effective protection or repair of the epithelial barrier and cell function after stress suggests potential clinical importance for patients with impaired or compromised barrier function such as might occur in IBS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 27, 2019

2012 journal article

Dietary Long-Chain PUFA Enhance Acute Repair of Ischemia-Injured Intestine of Suckling Pigs

The Journal of Nutrition, 142(7), 1266–1271.

By: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, A. Blikslager n & J. Odle n

Contributors: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, A. Blikslager n & J. Odle n

MeSH headings : Animals; Constriction; Diet; Dietary Fats / pharmacology; Dietary Supplements; Eicosapentaenoic Acid / pharmacology; Electric Impedance; Ileal Diseases / drug therapy; Ileal Diseases / pathology; Ileal Diseases / physiopathology; Ileum / drug effects; Ileum / pathology; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / blood; Ischemia / drug therapy; Ischemia / pathology; Ischemia / physiopathology; Mannitol / blood; Mesentery / blood supply; Swine; Wound Healing / drug effects
TL;DR: It is demonstrated that feeding elevated levels of long-chain PUFA enhances acute recovery of ischemia-injured porcine ileum, and a histological evaluation of ischemic ilea from piglets fed the 5% ARA showed reduced histological lesions after ischemIA compared with the other dietary groups. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Effect of a zincl-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo

American Journal of Veterinary Research, 73(5), 659–663.

By: T. Hill n & A. Blikslager n

Contributors: T. Hill n & A. Blikslager n

MeSH headings : Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Carnosine / administration & dosage; Carnosine / analogs & derivatives; Caspase 3 / chemistry; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Fluorescent Antibody Technique / veterinary; Gastric Acid / chemistry; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Hydrogen-Ion Concentration; In Vitro Techniques; Isotonic Solutions / chemistry; Organometallic Compounds / administration & dosage; Ringer's Solution; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Vitamin E / administration & dosage; Vitamin E / pharmacology; Zinc Compounds / administration & dosage
TL;DR: Addition of HCl caused a dose-dependent increase in gastric permeability over time and apparent induction of apoptosis as determined on the basis of immunofluorescence, which suggested the utility of this method for further studies of canine gastric injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa

World Journal of Gastroenterology, 18(34), 4684–4692.

By: M. Nighot n, A. Moeser, R. Ueno & A. Blikslager

Contributors: M. Nighot n, A. Moeser, R. Ueno & A. Blikslager

author keywords: Stomach; Mucosal permeability; ClC-2 chloride channel; Tight junction
MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channel Agonists; Chloride Channels / analysis; Cystic Fibrosis Transmembrane Conductance Regulator / analysis; Electric Impedance; Gastric Mucosa / drug effects; Mannitol / metabolism; Microscopy, Fluorescence; Permeability; Prostaglandins / pharmacology; Swine
TL;DR: ClC-2 agonist SPI-8811 stimulated enhancement of mucosal barrier function by protecting TJ protein occludin in porcine gastric mucosa and thus protected the gastric acid injury in porCine stomach. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 3, 2019

2012 journal article

Misoprostol: Is it safety or a lack of understanding that prevents its more frequent usage?

Equine Veterinary Journal, 45(1), 8–8.

By: A. Blikslager n

Contributors: A. Blikslager n

MeSH headings : Animals; Anti-Ulcer Agents / adverse effects; Anti-Ulcer Agents / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Misoprostol / adverse effects; Misoprostol / therapeutic use; Pregnancy; Ulcer / drug therapy; Ulcer / veterinary
TL;DR: The present manuscript provides strong evidence that misoprostol can be used safely and, more to the point, it is a viable option for mares with evidence of gastrointestinal mucosal injury and based on experimental evidence in horses with small intestinal ischaemic injury and evidence of success in nonsteroidal anti-inflammatory drug (NSAID)-induced colitis, misop frostol may be deserving of further studies for hastening mucosal repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

Pain management in horses | Schmerzmanagement beim Pferd

Praktische Tierarzt, 93(3), 223–226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879328604&partnerID=MN8TOARS

By: D. Nugent, A. Blikslager & T. Ferencz

Contributors: D. Nugent, A. Blikslager & T. Ferencz

Source: ORCID
Added: September 3, 2019

2012 journal article

Precision of a photogrammetric method to perform 3D wound measurements compared to standard 2D photographic techniques in the horse

Equine Veterinary Journal, 45(1), 41–46.

By: R. Labens n & A. Blikslager n

Contributors: R. Labens n & A. Blikslager n

author keywords: horse; wound; photogrammetry
MeSH headings : Animals; Horse Diseases / pathology; Horses / injuries; Image Processing, Computer-Assisted / instrumentation; Image Processing, Computer-Assisted / methods; Photography; Wound Healing / physiology; Wounds and Injuries / pathology; Wounds and Injuries / veterinary
TL;DR: The intraoperator repeatability of 3D wound measurements based on principles of stereophotogrammetry is significantly increased compared to that of a standard 2D photographic technique indicating it may be a useful diagnostic and monitoring tool. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2012 book

Principles of Intestinal Injury and Determination of Intestinal Viability

In Equine Surgery (pp. 411–416).

By: A. Blikslager* & J. Marshall

Contributors: A. Blikslager* & J. Marshall

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: ORCID
Added: September 3, 2019

2012 journal article

Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010)

Equine Veterinary Journal, 45(2), 224–228.

By: W. Davis n, C. Fogle n, M. Gerard n, J. Levine n & A. Blikslager n

Contributors: W. Davis n, C. Fogle n, M. Gerard n, J. Levine n & A. Blikslager n

author keywords: horse; colic; surgery; prognosis; performance
MeSH headings : Animals; Colic / surgery; Colic / veterinary; Female; Horse Diseases / surgery; Horses; Logistic Models; Male; Odds Ratio; Postoperative Complications
TL;DR: Targeted owner education regarding preoperative lameness, post operative rehabilitation and treatment for complications, such as incisional hernioplasty, may help inform owners about their horse's potential for return to use and performance following colic surgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2012 book

Stomach and Spleen

In Equine Surgery (pp. 388–402).

By: D. Wilson & A. Blikslager*

Contributors: D. Wilson & A. Blikslager*

Source: ORCID
Added: September 3, 2019

2012 journal article

Su1738 Misoprostol Protects Gastric Barrier Function After Acid Injury in an Ex Vivo Canine Model

Gastroenterology, 142(5), S-492.

By: T. Hill, A. Blikslager* & D. Lascelles*

Sources: Crossref, NC State University Libraries, ORCID
Added: January 22, 2019

2012 journal article

Su1751 The CLC-2 Agonist SPI-0811 Protects Against Indomethacin-Induced Epithelial Barrier Dysfunction in Human Gastric Epithelial Cells

Gastroenterology, 142(5), S-495.

By: M. Nighot, R. Ueno & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

Cecal impaction in horses

Compendium on Continuing Education for the Practising Veterinarian, 33(7), E1–4. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861449526&partnerID=MN8TOARS

By: A. Blikslager

Contributors: A. Blikslager

Sources: ORCID, NC State University Libraries
Added: September 3, 2019

2011 journal article

Cecal impaction in horses.

Compendium (Yardley, PA), 33(7). http://www.scopus.com/inward/record.url?eid=2-s2.0-84879314118&partnerID=MN8TOARS

By: A. Blikslager

Contributors: A. Blikslager

Source: ORCID
Added: September 3, 2019

2011 journal article

Chloride Channel CLC-2 Modulates Susceptibility to DSS-Induced Murine Colitis: Implications for the Role of the Tight Junction in IBD

Gastroenterology, 140(5), S-502.

By: P. Nighot, K. Young & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs

Journal of Veterinary Pharmacology and Therapeutics, 35(5), 452–459.

By: K. Messenger n, M. Papich n & A. Blikslager n

Contributors: K. Messenger n, M. Papich n & A. Blikslager n

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Bacteria / drug effects; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Subcutaneous; Microbial Sensitivity Tests; Swine / blood
TL;DR: It is demonstrated that the concentration of biologically active enrofloxacin in tissues exceeds the concentration predicted by the unbound fraction in pig plasma, and is sufficient for the pathogens that cause respiratory infections in pigs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses

American Journal of Veterinary Research, 72(2), 226–232.

By: J. Marshall n, A. Bhatnagar n, S. Bowman n, C. Howard n, N. Morris n, D. Skorich n, C. Redding n, A. Blikslager n

Contributors: J. Marshall n, A. Bhatnagar n, S. Bowman n, C. Howard n, N. Morris n, D. Skorich n, C. Redding n, A. Blikslager n

MeSH headings : Animals; Cyclooxygenase 1 / metabolism; Cyclooxygenase Inhibitors / pharmacology; Cyclooxygenase Inhibitors / therapeutic use; Diphenylamine / analogs & derivatives; Diphenylamine / pharmacology; Diphenylamine / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / pathology; Intestinal Diseases / veterinary; Ischemia / pathology; Ischemia / veterinary; Jejunum / pathology; Phenylacetates / pharmacology; Phenylacetates / therapeutic use
TL;DR: Robenacoxib selectively inhibited COX-2 and allowed recovery of barrier function in ischemia-injured equine jejunal tissue in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Hypoxia Disrupts Recovery of Injured Non-Transformed Small Intestinal Cells, but Not Transformed Cells

Gastroenterology, 140(5), S-699.

By: M. Brown & A. Blikslager*

TL;DR: Findings indicate that disruption of the Bach1 gene resulted in attenuation of I/R-challenged intestinal injury, indicating thathibition of Bach1 maybeanoveltherapeutic strategy for treatment against I/ R-mediatedintestinal injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

Indomethacin Decreases Recovery of Gastric Barrier Function After Acid Injury in a Novel Ex Vivo Canine Model

Gastroenterology, 140(5), S-319.

By: T. Hill & A. Blikslager*

TL;DR: Determination of microcirculatory changes In Vivo in human is possible during conventional endoscopic procedure by using Lazma system and it helps to point out the initial stages of damage to the gastric mucosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

Indomethacin Induces Gastric Epithelial Barrier Dysfunction via a p38 MAPK-Dependent Mechanism in MKN-28 Cells

Gastroenterology, 140(5), S-315.

By: M. Nighot & A. Blikslager*

TL;DR: Colonic tissue responds to IL-11 largely by activation of STAT3 signalling, which causes a large and significant increase in the expression of IL-33 and other mediators of the innate immune response in the absence of any significant damage to the mucosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008)

EQUINE VETERINARY EDUCATION, 23(4), 186–190.

By: K. Vainio, B. Sykes* & A. Blikslager n

Contributors: K. Vainio, B. Sykes* & A. Blikslager n

author keywords: horse; gastric impaction; enteral fluid therapy; gastroscopy; gastric ulceration
TL;DR: This is the largest group of horses reported that were treated with enteral fluid therapy for a gastric impaction and it was concluded that enteral fluids therapy was of value in this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

The Chloride Channel CLC-2 Modulates Tight Junction Barrier Function via Intracellular Trafficking

Gastroenterology, 140(5), S-503.

By: P. Nighot & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

The Chloride Channel CLC-2 is Involved in Organization of Murine Gastric Glands

Gastroenterology, 140(5), S-93.

By: M. Nighot, A. Blikslager* & P. Nighot

TL;DR: The phenotype of these two mouse models suggests that Hh signaling is necessary for the maintenance of the corpus epithelium and gastric epithelial cilia might be important for the function but not differentiation of gastrinand ghrelin-secreting cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2011 journal article

The effect of nonsteroidal anti-inflammatory drugs on the equine intestine

Equine Veterinary Journal, 43(SUPPL.39), 140–144.

By: J. Marshall* & A. Blikslager n

Contributors: J. Marshall* & A. Blikslager n

author keywords: horse; NSAID; intestine; injury
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / veterinary; Horse Diseases / chemically induced; Horses; Intestines / drug effects
TL;DR: Experimental evidence suggests that those NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action may offer significant advantages over traditional NSAIDs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo

Equine Veterinary Journal, 43(SUPPL.39), 106–111.

By: J. Marshall*, A. Bhatnagar, S. Bowman*, N. Morris, D. Skorich, C. Redding n, A. Blikslager n

Contributors: J. Marshall*, A. Bhatnagar, S. Bowman*, N. Morris, D. Skorich, C. Redding n, A. Blikslager n

TL;DR: Flunixin meglumine and AHI-805 inhibit recovery of barrier function in ischaemic-injured equine jejunum in vitro through inhibition of the COX enzymes. (via Semantic Scholar)
Sources: NC State University Libraries, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses

Journal of Veterinary Pharmacology and Therapeutics, 34(1), 12–16.

By: J. Davis*, J. Marshall*, M. Papich n, A. Blikslager* & N. Campbell n

Contributors: J. Davis*, J. Marshall*, M. Papich n, A. Blikslager* & N. Campbell n

MeSH headings : Animals; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Horses / blood; Horses / metabolism; Sulfonamides / blood; Sulfonamides / pharmacokinetics; Sulfonamides / pharmacology
TL;DR: It is shown that deracoxib is absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in the dog and horse. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusion

Equine Veterinary Journal, 43(SUPPL.39), 8–15.

By: A. Grosche*, A. Morton*, A. Graham*, L. Sanchez*, A. Blikslager n, M. Polyak*, D. Freeman*

Contributors: A. Grosche*, A. Morton*, A. Graham*, L. Sanchez*, A. Blikslager n, M. Polyak*, D. Freeman*

author keywords: horse; colon; TEM; tight junctions; autophagy; phagocytosis; immune cells
MeSH headings : Animals; Colon / pathology; Colon / ultrastructure; Colonic Diseases / pathology; Colonic Diseases / veterinary; Horse Diseases / pathology; Horses; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR: The morphology and ultrastructural changes in the epithelium in equine large colonic mucosa after I/R, and the response of inflammatory cells to injury are described to provide information on early changes in barrier properties, repair and inflammation in Equine colon after ischaemia and reperfusion. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

580 Intestinal Epithelial Barrier Alterations in CLC-2−/− Mice are Partially Regulated by MLCK

Gastroenterology, 138(5), S-82.

By: P. Nighot, S. Lee & A. Blikslager*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2010 journal article

A surgical tendonitis model in horses: Technique, clinical, ultrasonographic and histological characterisation

Veterinary and Comparative Orthopaedics and Traumatology, 23(4), 231–239.

By: M. Schramme*, S. Hunter*, N. Campbell*, A. Blikslager* & R. Smith*

Contributors: M. Schramme*, S. Hunter*, N. Campbell*, A. Blikslager* & R. Smith*

author keywords: Surgical model; tendonitis; horse; superficial digital flexor tendon
MeSH headings : Anesthesia, General / veterinary; Animals; Euthanasia, Animal; Follow-Up Studies; Forelimb / surgery; Horse Diseases / diagnostic imaging; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Postoperative Care / veterinary; Tendinopathy / diagnostic imaging; Tendinopathy / pathology; Tendinopathy / surgery; Tendinopathy / veterinary; Time Factors; Treatment Outcome; Ultrasonography / veterinary
TL;DR: The reported surgical technique resulted in core lesions that were consistent in size and location, were readily evaluated with ultrasonography, and showed similarities with the ultrasonographic and histological progression of naturally occurring tendonitis lesions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: September 3, 2019

2010 chapter

Alimentary diseases

In F. G. R. Taylor, T. Brazil, & M. H. Hillyer (Eds.), Diagnostic Techniques in Equine Medicine (2nd ed., pp. 27–72).

By: A. Blikslager

Ed(s): F. Taylor, T. Brazil & M. Hillyer

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 5, 2020

2010 book

Alimentary diseases

In Diagnostic Techniques in Equine Medicine: Second Edition (pp. 28–72). http://www.scopus.com/inward/record.url?eid=2-s2.0-84905885831&partnerID=MN8TOARS

By: A. Blikslager

Contributors: A. Blikslager

Source: ORCID
Added: September 3, 2019

2010 journal article

Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression

Virology, 401(2), 146–154.

By: P. Nighot n, A. Moeser n, R. Ali n, A. Blikslager n & M. Koci n

Contributors: P. Nighot n, A. Moeser n, R. Ali n, A. Blikslager n & M. Koci n

author keywords: Astrovirus; Viral enteritis; Malabsorption diarrhea; Sodium/hydrogen exchanger; Intestinal electrophysiology; Turkey
MeSH headings : Actins / metabolism; Animals; Astroviridae Infections / pathology; Astroviridae Infections / veterinary; Avastrovirus / pathogenicity; Cell Membrane / chemistry; Cytoplasm / chemistry; Gene Expression; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Poultry Diseases / pathology; Poultry Diseases / virology; Sodium / metabolism; Sodium-Hydrogen Exchangers / analysis; Turkeys
TL;DR: Data suggest astrovirus infection induces sodium malabsorption, possibly through redistribution of specific sodium transporters, which results in the development of an osmotic diarrhoea in infants and the immunocompromised. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction

American Journal of Physiology-Gastrointestinal and Liver Physiology, 299(2), G449–G456.

By: P. Nighot n & A. Blikslager n

Contributors: P. Nighot n & A. Blikslager n

author keywords: myosin light chain kinase; chloride channel; mannitol flux
MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / antagonists & inhibitors; Chloride Channels / deficiency; Chloride Channels / metabolism; Chlorides / pharmacology; Electrophysiological Phenomena; Ileum / drug effects; Ileum / metabolism; Ileum / physiology; Ileum / ultrastructure; In Vitro Techniques; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Intestinal Mucosa / ultrastructure; Mannitol / pharmacokinetics; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Electron, Scanning; Microvilli / ultrastructure; Myosin-Light-Chain Kinase / metabolism; Permeability; Phenotype; Tight Junctions / ultrastructure; Zinc Compounds / pharmacology
TL;DR: It is indicated that ClC-2 reduces barrier function in normal mucosa, and the mechanisms underlying these differing roles are not entirely clear, although ultrastructural morphology of tight junctions and MLCK appear to be important to the function of ClC -2 innormal mucosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Demographic characteristics of horses donated to the North Carolina State University Equine Health Center, 1996–2008

Journal of the American Veterinary Medical Association, 236(12), 1334–1337.

By: S. Bowman n, J. Marshall* & A. Blikslager*

Contributors: S. Bowman n, J. Marshall* & A. Blikslager*

MeSH headings : Animals; Cohort Studies; Demography; Education, Veterinary; Female; Horse Diseases / epidemiology; Horses; Male; North Carolina; Retrospective Studies; Universities
TL;DR: The most common reason given for unwanted horses offered for donation during 2007 and 2008 was musculoskeletal disease, with degenerative joint disease, lameness of undetermined cause, laminitis, and navicular disease being the most common musculosity conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

Dr Peter Rossdale, OBE, Editor Equine Veterinary Journal 1980-2010

Equine Veterinary Journal, 43(1), 2–2.

By: A. Blikslager n, R. Christley*, L. Jeffcott*, I. Silver* & R. Weeren*

Contributors: A. Blikslager n, R. Christley*, L. Jeffcott*, I. Silver* & R. Weeren*

MeSH headings : Editorial Policies; History, 20th Century; History, 21st Century; Periodicals as Topic / history
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(3), G352–G363.

By: F. Smith n, J. Clark n, B. Overman n, C. Tozel n, J. Huang n, J. Rivier*, A. Blisklager n, A. Moeser n

author keywords: weaning age; mast cells; corticotropin releasing factor
MeSH headings : Animals; Animals, Newborn; Barium Compounds / pharmacology; Cell Count; Chlorides / pharmacology; Corticotropin-Releasing Hormone / blood; Corticotropin-Releasing Hormone / metabolism; Corticotropin-Releasing Hormone / pharmacology; Cromolyn Sodium / pharmacology; Electric Impedance; Electrophysiological Phenomena / drug effects; Electrophysiological Phenomena / physiology; Female; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / metabolism; Ion Transport / physiology; Jejunum / drug effects; Jejunum / metabolism; Jejunum / pathology; Jejunum / physiopathology; Male; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / pathology; Permeability; Potassium / metabolism; Potassium Channel Blockers / pharmacology; Protease Inhibitors / pharmacology; Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors; Receptors, Corticotropin-Releasing Hormone / metabolism; Receptors, Glucocorticoid / metabolism; Stress, Physiological / physiology; Sus scrofa; Tryptases / metabolism; Weaning
TL;DR: It is shown that stress associated with early weaning in pigs leads to impaired mucosal barrier function, and activation of mast cells ex vivo with c48/80 and corticotrophin-releasing factor induced barrier dysfunction and elevations in short-circuit current that were inhibited with mast cell protease inhibitors. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2010 journal article

Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum | Wirkung von firocoxib oder flunixin auf die regeneration des ischämisch geschädigtem jejunum beim pferd

Pferdeheilkunde, 26(1), 100–101. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749270496&partnerID=MN8TOARS

By: V. Cook, C. Meyer, N. Campbell & A. Blikslager

Contributors: V. Cook, C. Meyer, N. Campbell & A. Blikslager

Source: ORCID
Added: September 3, 2019

2010 journal article

Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs

American Journal of Veterinary Research, 71(6), 630–635.

By: J. Wooten n, B. Lascelles n, V. Cook n, J. Law n & A. Blikslager n

Contributors: J. Wooten n, B. Lascelles n, V. Cook n, J. Law n & A. Blikslager n

MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
TL;DR: Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2010 chapter

Ischemic disorders of the intestinal tract

In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd edition, pp. 876–882). St. Louis, MO: Saunders Elsevier.

By: A. Blikslager

Ed(s): S. Reed, W. Bayly & D. Sellon

Source: NC State University Libraries
Added: October 18, 2020

2010 journal article

Long Toes in the Hind Feet and Pain in the Gluteal Region: An Observational Study of 77 Horses

JOURNAL OF EQUINE VETERINARY SCIENCE, 30(12), 720–726.

By: R. Mansmann n, S. James n, A. Blikslager n & K. Orde n

Contributors: R. Mansmann n, S. James n, A. Blikslager n & K. Orde n

author keywords: Horse; foot; Hoof; Toe; Gluteal; Pain
TL;DR: The conclusion is that excessive toe length in the hind feet may be accompanied by pain in the gluteal region and, in the experience, may be associated with gait or performance problems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

M1863 Indomethacin Impedes Recovery From Hypoxia-Reoxygenation in CACO-2 Cells

Gastroenterology, 138(5), S-434.

By: J. Marshall & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2010 journal article

Mucosal epithelial barrier repair to maintain pig health

Livestock Science, 133(1-3), 194–199.

By: A. Blikslager n

Contributors: A. Blikslager n

author keywords: Restitution; Tight junction; Villus contraction; Epithelium; Sepsis
TL;DR: Mucosal barrier function is critical to prevent translocation of microorganisms and their toxins and the prominent contribution of the paracellular space to measures of barrier function such as transepithelial electrical resistance is highlighted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: September 3, 2019

2010 chapter

Obstructive disorders of the gastrointestinal tract

In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd edition, pp. 882–892). St. Louis, MO: Saunders Elsevier.

By: A. Blikslager

Ed(s): S. Reed, W. Bayly & D. Sellon

Source: NC State University Libraries
Added: October 18, 2020

2010 chapter

Pathophysiology of mucosal injury and repair

In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd edition, pp. 794–802). St. Louis, MO: Saunders Elsevier.

By: A. Blikslager

Ed(s): S. Reed, W. Bayly & D. Sellon

Source: NC State University Libraries
Added: October 18, 2020

2010 journal article

S1779 The Chloride Channel CLC-2 Modulates Early Barrier Development in CACO-2 Cells

Gastroenterology, 138(5), S-272.

By: P. Nighot, R. Turner, S. Lee & A. Blikslager*

Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2010 journal article

TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

The Journal of Immunology, 185(8), 4729–4737.

Contributors: R. Kajino-Sakamoto n, E. Omori n, P. Nighot n, A. Blikslager n, K. Matsumoto* & J. Ninomiya-Tsuji n

MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
TL;DR: It is reported that TGF-β–activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium and regulates ROS through transcription factor NF-E2–related factor 2, which is important for intestinal epithelial integrity. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

665 The Role of the Intestinal Microbiota in Colonic Barrier Dysfunction Induced By Neonatal Stress

Gastroenterology, 136(5), A-102.

By: A. Moeser, A. Blikslager*, S. Tonkonogy & T. Keku

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020

2009 journal article

Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses

American Journal of Veterinary Research, 70(10), 1259–1268.

By: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n

Contributors: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, A. Blikslager n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / adverse effects; Clonixin / analogs & derivatives; Female; Gene Expression Regulation, Enzymologic / drug effects; Horse Diseases / chemically induced; Horse Diseases / drug therapy; Horses; Intestinal Diseases / chemically induced; Intestinal Diseases / veterinary; Ischemia / chemically induced; Jejunum / drug effects; Lidocaine / therapeutic use; Male; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / metabolism
TL;DR: In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 chapter

Cecal impaction

In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th edition, pp. 405–407). St. Louis: Saunders Elsevier.

By: A. Blikslager

Ed(s): N. Robinson & K. Sprayberry

Source: NC State University Libraries
Added: October 18, 2020

2009 journal article

ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum

Experimental Cell Research, 315(1), 110–118.

By: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & A. Blikslager n

Contributors: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & A. Blikslager n

author keywords: Tight junction; Intestinal permeability; Ischemia; ClC-2
MeSH headings : Animals; CLC-2 Chloride Channels; Cell Membrane / metabolism; Chloride Channels / deficiency; Chloride Channels / metabolism; Epithelium / metabolism; Epithelium / pathology; Epithelium / ultrastructure; Fluorescent Antibody Technique; Immunoprecipitation; Ischemia / metabolism; Ischemia / physiopathology; Jejunum / blood supply; Jejunum / pathology; Jejunum / ultrastructure; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Protein Transport; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Wound Healing
TL;DR: A pivotal role is demonstrated in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury in ClC-2(-/-) mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum

American Journal of Veterinary Research, 70(8), 992–1000.

By: V. Cook n, C. Meyer n, N. Campbell n & A. Blikslager n

Contributors: V. Cook n, C. Meyer n, N. Campbell n & A. Blikslager n

MeSH headings : 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Blotting, Western / veterinary; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Eicosanoids / blood; Electrophoresis, Polyacrylamide Gel / veterinary; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Jejunal Diseases / drug therapy; Jejunal Diseases / veterinary; Sulfones / therapeutic use; Thromboxane B2 / blood
TL;DR: Firocoxib may be advantageous in horses recovering from ischemic intestinal injury, while providing effective analgesia in horses treated with flunixin meglumine and firo Coxib. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs

American Journal of Veterinary Research, 70(10), 1243–1249.

By: J. Wooten n, A. Blikslager n, S. Marks n, J. Law n, E. Graeber n & B. Lascelles n

Contributors: J. Wooten n, A. Blikslager n, S. Marks n, J. Law n, E. Graeber n & B. Lascelles n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Dogs; Drug Administration Schedule; Female; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Gene Expression Regulation / drug effects; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism
TL;DR: It is suggested that, for these experimental conditions, there were no differences among the preferential and selective COX-2 inhibitors with regard to adverse effects on the gastric and duodenal portions of the gastrointestinal tract of dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses

American Journal of Veterinary Research, 70(12), 1536–1544.

By: A. Morton n, A. Grosche n, A. Rötting n, S. Matyjaszek n, A. Blikslager n & D. Freeman n

Contributors: A. Morton n, A. Grosche n, A. Rötting n, S. Matyjaszek n, A. Blikslager n & D. Freeman n

MeSH headings : Animals; Colitis, Ischemic / veterinary; Colon / blood supply; Colon / metabolism; Colon / pathology; Cyclooxygenase 1 / genetics; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression Regulation, Enzymologic; Horse Diseases / metabolism; Horse Diseases / pathology; Horses; Reperfusion Injury / metabolism; Reperfusion Injury / veterinary; Time Factors
TL;DR: It is suggested that upregulation of COX-2 in surface epithelium and crypt cells following ischemic injury in equine colon may represent an early step in the repair process. (via Semantic Scholar)
UN Sustainable Development Goal Categories