Anthony T Blikslager
Intestine, tight junction, colic, large animal, horse, pig, physiology, transport, ischemia, injury
Works (367)
Updated: November 18th, 2024 11:06
2024 journal article
Equine Enteric Glial Culture and Application to the Study of A Neural Inflammatory Mechanism in Equine Colic
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 10(212).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2024
2024 journal article
Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 15(1).
author keywords: Galactooligosaccharide; Gut microbiome; Intestinal villi; Prebiotics; Weaning
open access via jasbsci.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 15, 2024
2024 journal article
Protocol Protocol to culture enteric glial cells from the submucosal and myenteric plexi of neonatal and juvenile pig colons
STAR PROTOCOLS, 5(2).
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024
2024 article
Trends in the management of horses referred for colic evaluation preceding and during the COVID-19 pandemic (2013-2023)
Elane, G. L., Blikslager, A. T., & Mair, T. S. (2024, August 19). EQUINE VETERINARY EDUCATION, Vol. 8.
author keywords: horse; accession; colic; COVID-19; pandemic
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024
2023 journal article
A novel case of tracheal injury secondary to gunshot trauma in a white rhinoceros (Ceratotherium simum)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 261(10).
author keywords: rhinoceros; tracheal wound; gunshot; poaching; endoscopy
TL;DR:
Although more aggressive therapy including surgery may likely be considered in zoo or domestic animals, limited conservative treatment was successful in this wild-managed rhinoceros.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 27, 2023
2023 article
Effects of Prebiotic Galactooligosaccharide (GOS) on Hindgut Microbial Composition of Pigs During the Peri-Weaning Period
Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 187–188.
author keywords: microbiome; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2023 article
Effects of Prebiotic Galactooligosaccharide (Gos) on Piglet Growth and Jejunal Morphology During the Peri-Weaning Period
Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, October 28). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 276–277.
author keywords: intestinal villi; galactooligosaccharides; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2023 journal article
Hypoxia Primes Human ISCs for Interleukin-Dependent Rescue of Stem Cell Activity
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 16(5), 823–846.
author keywords: Inflammatory Hypoxia; Microphysiological System; Intestinal Stem Cells; Stem Cell Priming; Oxygen Sensor; Cytokines
TL;DR:
A new microphysiological system (MPS) is presented to investigate how hypoxia affects hISCs from healthy donors and test the hypothesis that prolongedHypoxia modulates how hISC respond to inflammation-associated interleukins (ILs) and has important implications for understanding intestinal epithelial regeneration mechanisms caused by inflammatory hypoxIA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 6, 2023
2023 journal article
Retrospective analysis of postoperative complications following surgical treatment of ileal impaction in horses managed with manual decompression compared to jejunal enterotomy
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: colic; ileum; impaction; enterotomy; manual decompression
TL;DR:
It was showed that there were no significant differences in post-operative complications and survival to discharge in horses undergoing distal jejunal enterotomy versus manual decompression for correction of ileal impaction, and pre-operative PCV and duration of surgery were found to be the only predictive factors of survival to discharged.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023
2023 journal article
Risk factors associated with an outbreak of equine coronavirus at a large farm in North Carolina
FRONTIERS IN VETERINARY SCIENCE, 10.
author keywords: ECoV; coronavirus; colic; diarrhea; small colon impaction
TL;DR:
Clinical findings and risk factors for ECoV infection many of which were associated with intensive management of show horses were described, and clinicians should be aware that clinical signs vary and can include severe colic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023
2022 journal article
Immunologic and pathologic characterization of a novel swine biomedical research model for eosinophilic esophagitis
FRONTIERS IN ALLERGY, 3.
author keywords: pig; food allergy; animal model; immunology; gastrointestinal; eosinophilic esophagitis
TL;DR:
Swine is established as a relevant large animal model for translational biomedical research in EoE with the potential to facilitate development of therapeutics and it is demonstrated that the sensitization and oral challenge protocol not only induces the underlying immune markers but also the micro- and macro-pathological hallmarks of human EiE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 25, 2023
2022 article
Mechanisms and modeling of wound repair in the intestinal epithelium
Boger, K. D., Sheridan, A. E., Ziegler, A. L., & Blikslager, A. T. (2022, June 13). TISSUE BARRIERS, Vol. 6.
author keywords: IPEC-J2 cells; transepithelial electrical resistance; injury barrier function; cell model
MeSH headings : Humans; Caco-2 Cells; Intestinal Mucosa / metabolism; Intestines; Ischemia
TL;DR:
This review focuses on in vitro injury models and intestinal cell lines utilized in such systems and the use of intestine cell lines, IPEC-J2, Caco-2, T-84, HT-29, and IEC-6, to model intestinal epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2022
2022 journal article
Multi-Institutional Retrospective Case-Control Study Evaluating Clinical Outcomes of Foals with Small Intestinal Strangulating Obstruction: 2000-2020
ANIMALS, 12(11).
author keywords: horse; colic; foal; ischemia; small intestinal strangulating obstruction; surgery
TL;DR:
Unexpectedly, short-term survival tended to be higher in foals than adults and may have been partly driven by case selection prior to referral or surgery or decision-making intraoperatively, and more optimism toward surgical treatment of foals with suspected SISO may be warranted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 28, 2022
2022 article
Non-steroidal anti-inflammatory drugs in equine orthopaedics
Jacobs, C. C., Schnabel, L. V., McIlwraith, C. W., & Blikslager, A. T. (2022, February 10). EQUINE VETERINARY JOURNAL, Vol. 2.
author keywords: horse; non-steroidal anti-inflammatory drug; orthopaedics; osteoarthritis
TL;DR:
This review aims to summarise the current literature on the use of NSAIDs for equine orthopaedic disorders and examines new and future avenues for the management of inflammation in equine Orthopaedics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 28, 2022
2022 review
Porcine Models of the Intestinal Microbiota: The Translational Key to Understanding How Gut Commensals Contribute to Gastrointestinal Disease
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: intestinal microbiota; translational models; pig models; gut commensals; gastrointestinal disease
TL;DR:
To further elucidate the pathogenesis of these disease syndromes as well as uncover novel therapies and preventative measures, gastrointestinal researchers should consider the pig as a powerful, translational model of the gastrointestinal microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 23, 2022
2021 journal article
Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic
ANIMALS, 11(12).
author keywords: horse; colic; ischemia-reperfusion injury; intestinal barrier repair; enteric nervous system; enteric glial cells; tight junction proteins
TL;DR:
The current understanding of the roles of the gut microbiome, nutrition, stress, and the ENS in maturation of intestinal repair mechanisms after foaling is reviewed and how this may influence age-dependent outcomes in equine colic cases is reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 25, 2021
2021 journal article
In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model
PLOS ONE, 16(4).
MeSH headings : Administration, Oral; Animals; Celiac Disease / drug therapy; Drug Liberation; Duodenum / metabolism; Jejunum / metabolism; Oligopeptides / administration & dosage; Oligopeptides / pharmacokinetics; Oligopeptides / therapeutic use; Swine
TL;DR:
The data shows that LA is available in detectable concentrations at the site of CeD, with a sensitive liquid chromatography/tandem mass spectrometry method developed to quantify LA concentrations in porcine intestinal fluid samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021
2021 journal article
Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions
PLOS ONE, 16(4).
MeSH headings : Animals; Disease Models, Animal; Female; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Ischemia / drug therapy; Ischemia / metabolism; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Male; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability / drug effects; Swine; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR:
It is concluded that LA stimulates repair of ischemic-injured epithelium at the level of the tight junctions, at an optimal dose of 1 μM LA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 review
Larazotide acetate: a pharmacological peptide approach to tight junction regulation
[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 320(6), G983–G989.
author keywords: barrier function; celiac disease; tight junction
MeSH headings : Animals; Celiac Disease / drug therapy; Celiac Disease / metabolism; Humans; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR:
Small and large animal studies have been conducted that demonstrate the importance of LA as a tight junction regulatory peptide in conditions other than celiac disease, including collagen-induced arthritis in mice and intestinal ischemic injury in pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021
2021 review
Postoperative Ileus: Comparative Pathophysiology and Future Therapies
[Review of ]. FRONTIERS IN VETERINARY SCIENCE, 8.
author keywords: intestine; equine; surgery; barrier function; enteric glia and neurons; microbiota
TL;DR:
Understanding of the roles of the gastrointestinal microbiota, intestinal barrier function, the post-surgical inflammatory response, as well as enteric glial cells, a component of the enteric nervous system, in modulating postoperative gastrointestinal motility and the pathogenesis of POI may provide future targets for prevention and/or therapy ofPOI.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2021
2021 journal article
Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function
International Journal of Molecular Sciences, 22(13), 6729.
author keywords: probiotics; prebiotics; bioactive compounds; intestinal barrier function; tight junctions; toll-like receptors; intestinal microbiota
MeSH headings : Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / physiology; Humans; Infant; Intestinal Mucosa / cytology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiology; Prebiotics; Probiotics / pharmacology; Tight Junction Proteins / metabolism; Tight Junctions / metabolism; Toll-Like Receptors / metabolism
TL;DR:
Current views on the effects of pro- and prebiotics on the intestinal epithelial barrier as well as on non-epithelial cell barrier constituents, such as the enteric glial cell network are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 24, 2021
2021 journal article
Steroid Eluting Esophageal-Targeted Drug Delivery Devices for Treatment of Eosinophilic Esophagitis
POLYMERS, 13(4).
author keywords: eosinophilic esophagitis (EoE); esophageal drug delivery systems; drug-eluting string; 3D printing; photopolymerizable resins; Drug loading strategies; steroids; fluticasone
TL;DR:
Two novel esophageal-specific drug delivery platforms are reported, including a fluticasone-eluting string that could be swallowed similar to the string test “entero-test” and used for overnight treatment, and a 3D printed ring for local and sustained release of flutic asone in the esophagus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 18, 2021
2020 article
A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia
Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
It is hypothesized that EGC inhibition in juveniles will block epithelial barrier repair after ischemic injury mimicking the neonatal phenotype, and the development of glial‐epithelial crosstalk in barrier repair will ultimately guide novel clinical solutions to improve outcomes in neonatal patients affected by intestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2020 article
Effects of Environmental Acclimation versus Transport Stress on Barrier Recovery in a Pig Model of Intestinal Ischemia and Repair
Ziegler, A., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
The results indicate that acute transport stress on the day of experimental intestinal injury modeling may increase mucosal susceptibility to epithelial loss, but also prime the tissue for a more robust barrier repair response.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 article
Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model
Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
Test the effects of dietary oligosaccharides on postnatal changes in the EGC network and intestinal morphology in a neonatal pig model to find increased mucosal expression of EGC markers earlier in postnatal development in the high oligOSaccharide group, as well as histological changes consistent with enhanced rates of gut maturation in pigs fed a high oligosACcharide diet.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2020 journal article
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model
TISSUE BARRIERS, 8(4).
author keywords: Intestinal barrier; ischemia; stress; pig model; tight junctions
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / physiopathology; Ischemia / physiopathology; Permeability; Swine
TL;DR:
The effects of a period of environmental acclimation versus acute transport stress on mucosal barrier repair after intestinal ischemic injury and recovery are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 27, 2020
2020 journal article
Lubiprostone protects esophageal mucosa from acid injury in porcine esophagus
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 318(4), G613–G623.
author keywords: ClC-2; esophagus; injury; lubiprostone; repair
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Bumetanide / pharmacology; Chloride Channel Agonists / pharmacology; Chloride Channels / genetics; Chloride Channels / metabolism; Chlorides / pharmacology; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / metabolism; Dose-Response Relationship, Drug; Esophageal Mucosa / drug effects; Female; Gene Expression Regulation / drug effects; Hydrochloric Acid / pharmacology; Lubiprostone / pharmacology; Male; Occludin / metabolism; Swine; Time Factors; Zinc Compounds / pharmacology
TL;DR:
It is concluded that ClC-2 contributes to esophageal protection from acid exposure, potentially offering a new therapeutic target.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020
2020 chapter
Surgical disorders of the large intestine
In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th edition). St. Louis, MO: Elsevier.
Ed(s): B. Smith, D. Van Metre & N. Pusterla
Source: NC State University Libraries
Added: October 18, 2020
2020 chapter
Surgical disorders of the small intestine
In B. P. Smith, D. C. Van Metre, & N. Pusterla (Eds.), Large Animal Internal Medicine (6th edition). St. Louis: Elsevier.
Ed(s): B. Smith, D. Van Metre & N. Pusterla
Source: NC State University Libraries
Added: October 18, 2020
2020 journal article
The Integral Role of Tight Junction Proteins in the Repair of Injured Intestinal Epithelium
International Journal of Molecular Sciences.
author keywords: barrier function; tight junction; repair; occludin; claudin; NHE2; ClC-2
MeSH headings : Animals; Humans; Intestinal Diseases / metabolism; Intestinal Diseases / pathology; Intestinal Diseases / prevention & control; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Tight Junction Proteins / metabolism
TL;DR:
This review provides an overview of the tight junction complex components and how they link to other plasmalemmal proteins, such as ion channels and transporters, to induce tight junction closure during repair of acute injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: February 6, 2020
2020 journal article
The Regulation of Intestinal Mucosal Barrier by Myosin Light Chain Kinase/Rho Kinases
International Journal of Molecular Sciences.
author keywords: myosin light chain kinase; rho-associated coiled-coil containing protein kinase; apical junction complex; tight junction; adherens junction
MeSH headings : Animals; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Myosin-Light-Chain Kinase / metabolism; Myosin-Light-Chain Kinase / physiology; Permeability; Tight Junctions / metabolism; rho-Associated Kinases / metabolism; rho-Associated Kinases / physiology
TL;DR:
The current state of knowledge regarding the role of MLCK- and ROCK-mediated pathways in the regulation of the intestinal barrier during normal homeostasis and digestive diseases is summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: May 23, 2020
2020 journal article
Trends in the management of horses referred for evaluation of colic: 2004-2017
Equine Veterinary Education.
author keywords: horse; colic
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 21, 2020
2020 journal article
Ultrasound findings in tendons and ligaments of lame sport horses competing or training in South Florida venues during the winter seasons of 2007 through 2016
EQUINE VETERINARY EDUCATION, 33(6), 306–309.
author keywords: horse; sport horse; lameness; ultrasonography; suspensory ligament; inferior check ligament; superficial and deep digital flexor tendons
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 article
iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model
Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 12, 2020
2019 review
Colic Prevention to Avoid Colic Surgery: A Surgeon's Perspective
[Review of ]. JOURNAL OF EQUINE VETERINARY SCIENCE, 76, 1–5.
author keywords: Forage; Impaction; Volvulus; Lipoma
MeSH headings : Animals; Colic / veterinary; Colonic Diseases / veterinary; Horse Diseases; Horses; Humans; Male; Surgeons
TL;DR:
Understanding management risk factors can lead to recommendations that prevent colic in horses, and additional study of these factors may ultimately lead to reductions in the prevalence of colic by suggesting optimal management practices.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 28, 2019
2019 journal article
Disease features of equine coronavirus and enteric salmonellosis are similar in horses
Journal of Veterinary Internal Medicine, 33(2), 912–917.
author keywords: colic; equine coronavirus; fever; salmonella
MeSH headings : Animals; Betacoronavirus 1 / isolation & purification; Blood Cell Count / veterinary; Blood Chemical Analysis / veterinary; Communicable Diseases, Emerging; Coronavirus Infections / diagnosis; Coronavirus Infections / veterinary; Diagnosis, Differential; Feces / microbiology; Female; Horse Diseases / diagnosis; Horse Diseases / microbiology; Horses; Male; Retrospective Studies; Salmonella / isolation & purification; Salmonella Infections, Animal / diagnosis
TL;DR:
Equine coronavirus and Salmonella infections share clinical features, suggesting both diseases should be differential diagnoses for horses with fever and enteric clinical signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: April 22, 2019
2019 journal article
Letter to the Editor: Bias in statistics or bias in equine veterinary medicine?
Equine Veterinary Journal, 51(3), 423–423.
MeSH headings : 4-Butyrolactone / analogs & derivatives; Animals; Clonixin / analogs & derivatives; Horses; Sulfones
TL;DR:
It is proposed that validating a trend towards improved survival in horses treated with firocoxib would require additional studies with greater numbers of horses and likely modification of the study design to include preoperative drug randomisation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: May 6, 2019
2019 personal communication
Letter to the Editor: Post-operative reflux - a surgeon's perspective
Blikslager, A. T. (2020, January).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 1, 2021
2019 journal article
Preservation of reserve intestinal epithelial stem cells following severe ischemic injury
American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(4), G482–G494.
author keywords: intestine; ischemia reperfusion injury; large animal model; reserve stem cells; stem cell
MeSH headings : Animals; Apoptosis; Cell Proliferation / physiology; Cell Self Renewal / physiology; Cell Survival / physiology; Disease Models, Animal; Homeodomain Proteins / metabolism; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Ischemia / metabolism; Receptors, G-Protein-Coupled / metabolism; Reperfusion Injury / metabolism; Swine
TL;DR:
Data indicate that Hopx+ cells are resistant to injury and are the likely source of epithelial renewal following prolonged ischemic injury, and it is therefore possible that targeting reserve stem cells will lead to new therapies for patients with severe intestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: March 16, 2019
2018 journal article
138 - Knockout of CLC-2 Reveals Critical Functions of Adherens Junctions in Colonic Homeostasis and Tumorigenicity
Gastroenterology, 154(6), S-37-S-38.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2018 journal article
Advances in Diagnostics and Treatments in Horses with Acute Colic and Postoperative Ileus
Veterinary Clinics of North America: Equine Practice, 34(1), 81–96.
author keywords: Acute colic; Novel diagnostic biomarkers; Systemic inflammatory response syndrome (SIRS); Pain and motility management
MeSH headings : Acute Disease; Animals; Colic / diagnosis; Colic / surgery; Colic / therapy; Colic / veterinary; Horse Diseases / diagnosis; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Ileus; Postoperative Complications / etiology; Postoperative Complications / veterinary
TL;DR:
Investigation of novel biomarkers, which may help to differentiate surgical lesions from those that can be managed medically, continues to be an active area of research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2018 chapter
Colic
In Equine Surgery (pp. 521–528).
TL;DR:
Colic is abdominal pain normally caused by a gastrointestinal disorder; however, horses may also exhibit signs of colic with non-intestinal disorders (e.g. shipping fever, ruptured bladder, rupturing uterine artery in mares).
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2018 journal article
Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs
Journal of Veterinary Internal Medicine, 32(2), 670–678.
author keywords: barrier function; stress ulcer; transepithelial electrical resistance; Ussing chamber
MeSH headings : Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Hydrogen-Ion Concentration; In Vitro Techniques; Isotonic Solutions; Ringer's Solution; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Sucralfate / administration & dosage; Sucralfate / pharmacology
TL;DR:
Sorbitfate appeared effective at restoring defects in gastric barrier function induced by acid and accelerating repair of tissues subjected to acid in this model, suggesting that sucralfate could have utility for the treatment and prevention of SRMD in dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2018 journal article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
PLOS ONE, 13(8), e0200674.
Contributors: A. Ziegler n , T. Pridgen n, J. Mills n, L. Gonzalez n , L. Van Landeghem n, J. Odle n , n
Ed(s): J. Karhausen
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR:
Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 16, 2018
2018 journal article
Equine intestinal mucosal pathobiology
Annual Review of Animal Biosciences, Vol 6, 6, 157–175.
Source: NC State University Libraries
Added: August 6, 2018
2018 journal article
Evaluation of digital cryotherapy using a commercially available sleeve style ice boot in healthy horses and horses receiving i.v. endotoxin
EQUINE VETERINARY JOURNAL, 50(6), 848–853.
author keywords: horse; digital cryotherapy; sepsis-associated laminitis; sleeve-style ice boot; lamellar temperatures
MeSH headings : Animals; Cross-Over Studies; Cryotherapy / instrumentation; Cryotherapy / standards; Cryotherapy / veterinary; Endotoxins / administration & dosage; Endotoxins / blood; Female; Foot Diseases / therapy; Foot Diseases / veterinary; Forelimb; Hoof and Claw / pathology; Horse Diseases / therapy; Horses; Male; Prospective Studies; Random Allocation; Skin Temperature
TL;DR:
This study is the first to show that a sleeve style boot, where ice does not cover the hoof, can cause significant decreases in lamellar temperatures through cooling of blood as it travels to the foot.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018
2018 journal article
IDENTIFICATION OF A NASOCONCHAL PARANASAL SINUS IN THE WHITE RHINOCEROS (CERATOTHERIUM SIMUM)
JOURNAL OF ZOO AND WILDLIFE MEDICINE, 49(2), 444–449.
author keywords: Anatomy; Ceratotherium simum; nasal sinus; nasocon
MeSH headings : Animals; Cadaver; Craniocerebral Trauma / diagnostic imaging; Craniocerebral Trauma / veterinary; Female; Head / diagnostic imaging; Horns / injuries; Paranasal Sinuses / diagnostic imaging; Perissodactyla / anatomy & histology; Tomography, X-Ray Computed / veterinary; Veterinary Medicine / methods
TL;DR:
The anatomy of the most commonly injured area of the head of the white rhinoceros, the nasoconchal sinus, was identified and confirmed to be readily exposed by horn removal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Intestinal Stem Cell Isolation and Culture in a Porcine Model of Segmental Small Intestinal Ischemia
Journal of Visualized Experiments, 5(135).
author keywords: Medicine; Issue 135; Porcine; intestine; ischemia-reperfusion; stem cell; enteroid; organoid
MeSH headings : Animals; Cell Culture Techniques / methods; Disease Models, Animal; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Intestine, Small / pathology; Ischemia / etiology; Mice; Stem Cells / metabolism; Swine
TL;DR:
By utilizing a porcine model, a protocol is established in which segmental loops of intestinal ischemia can be created within a single animal, enabling the study of differing time points of ischemic injury and repair in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 16, 2018
2018 journal article
Knockout of ClC-2 reveals critical functions of adherens junctions in colonic homeostasis and tumorigenicity
American Journal of Physiology-Gastrointestinal and Liver Physiology, 315(6), G966–G979.
author keywords: adherens junction; chloride channel ClC-2; colonic homeostasis; colonic tumorigenicity; colonoids
MeSH headings : Adherens Junctions / metabolism; Adherens Junctions / pathology; Animals; CLC-2 Chloride Channels; Carcinogenesis / genetics; Carcinogenesis / metabolism; Chloride Channels / genetics; Chloride Channels / metabolism; Colitis, Ulcerative / complications; Colonic Neoplasms / etiology; HT29 Cells; Homeostasis; Humans; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Mice; Mice, Inbred C57BL; Signal Transduction; beta Catenin / metabolism
TL;DR:
Disruption of adherens junctions in the absence of chloride channel protein-2 revealed critical functions of these junctional structures, including maintenance of colonic homeostasis and differentiation as well as driving tumorigenicity by regulating β-catenin signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 31, 2018
2018 journal article
Mo1169 - Role of Cftr and Clc-2 in Esophageal Barrier Function
Gastroenterology, 154(6), S-694.
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2018 journal article
Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction
Equine Veterinary Journal, 51(3), 329–335.
author keywords: horse; colic; endotoxaemia; flunixin meglumine; firocoxib; clinical study
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Obstruction / complications; Intestinal Obstruction / veterinary; Male; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Random Allocation; Sulfones / administration & dosage; Sulfones / therapeutic use
TL;DR:
Treatment of post-surgical SISO horses with firocoxib (COX-2 selective) would reduce the signs of endotoxaemia to a greater extent than flunixin meglumine (nonselective COX inhibitor) while continuing to provide similar levels of pain control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: May 6, 2019
2018 chapter
Principles of Intestinal Injury and Determination of Intestinal Viability
In Equine Surgery (pp. 529–536).
TL;DR:
Intestinal injury, although typically associated with ischemic lesions, occurs during any obstructive intestinal disease to varying degrees depending on the type of obstruction and the extent of vascular compromise.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2018 journal article
Sa1183 - Larazotide Stimulates Recovery of Ischemic-Injured Intestine in a Dose-Dependent Manner Associated with Restoration of Tight Junctions
Gastroenterology, 154(6), S-270.
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2018 chapter
Stomach and Duodenum
In Equine Surgery (pp. 496–505).
TL;DR:
These reviews are intended to update practitioners and researchers regarding recent developments in gastroduodenal physiology and pathophysiology as well as management of gastroduODenal disorders.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2018 journal article
Su2039 - Larazotide Stimulates Recovery of Ischemic-Injured Intestine in the Presence of the Non-Steroidal Anti-Inflammatory Drug (NSAID) Indomethacin Related to Recovery of Tight Junctions
Gastroenterology, 154(6), S-1365.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2018 chapter
Transverse and Small Colon
In Equine Surgery (pp. 621–631).
Sources: Crossref, NC State University Libraries
Added: December 5, 2019
2017 journal article
A Novel Inflammation-Activated Drug Delivery System Using Self-Assembling Hydrogel Doubles Esophageal Dwell Time in an Esophageal Injury Porcine Model
Gastroenterology, 152(5), S859–S860.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2017 journal article
An update on equine post-operative ileus: Definitions, pathophysiology and management
Equine Veterinary Journal, 50(3), 292–303.
author keywords: horse; colic; surgery; POI; abdomen; gastrointestinal motility
MeSH headings : Animals; Horse Diseases / etiology; Horse Diseases / physiopathology; Horse Diseases / therapy; Horses; Ileus / etiology; Ileus / physiopathology; Ileus / veterinary; Intestinal Pseudo-Obstruction / etiology; Intestinal Pseudo-Obstruction / physiopathology; Intestinal Pseudo-Obstruction / veterinary; Postoperative Complications / physiopathology; Postoperative Complications / therapy; Postoperative Complications / veterinary; Risk Factors
TL;DR:
Despite many pharmacological trials in all species, there is no single completely successful treatment for POI, highlighting that the condition is multifactorial in cause and requires a multimodal approach to minimise its incidence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Ductular and proliferative response of esophageal submucosal glands in a porcine model of esophageal injury and repair
American Journal of Physiology-Gastrointestinal and Liver Physiology, 313(3), G180–G191.
author keywords: esophagus; injury; repair; esophageal submucosal gland; proliferation
MeSH headings : Active Transport, Cell Nucleus; Animals; Cell Proliferation / physiology; Esophageal Diseases / pathology; Esophagus / cytology; Esophagus / injuries; Female; Gene Expression Regulation / physiology; Humans; Male; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Staining and Labeling; Swine
TL;DR:
A novel porcine model of injury and repair using radiofrequency ablation has been developed, allowing for reproducible injury to the esophagus to study repair in an animal model with esophageal submucosal glands, a key anatomical feature and missing in rodent models but possibly harboring progenitor cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Equine Intestinal Mucosal Pathobiology
Annual Review of Animal Biosciences, 6(1), 157–175.
author keywords: horse; intestine; ischemia; barrier function; stem cell niche; enteroid
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Colic / complications; Colic / pathology; Colic / veterinary; Horse Diseases / pathology; Horses; Inflammation / drug therapy; Inflammation / veterinary; Intestinal Mucosa / pathology; Intestinal Obstruction / veterinary; Ischemia / pathology; Ischemia / veterinary; Regeneration; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR:
Mechanisms of repair, including villus contraction, epithelial restitution, and tight junction closure, are critical to reforming the mucosal barrier and completion of mucosal regeneration requires proliferation, which is now being actively studied in equine enteroids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2017 journal article
Impaired intestinal barrier function and relapsing digestive disease: Lessons from a porcine model of early life stress
Neurogastroenterology & Motility, 29(11), e13216.
author keywords: early life adversity; intestinal barrier function; irritable bowel syndrome; porcine models
MeSH headings : Animals; Disease Models, Animal; Gastrointestinal Diseases / etiology; Gastrointestinal Diseases / physiopathology; Humans; Recurrence; Stress, Psychological / complications; Sus scrofa; Translational Research, Biomedical
TL;DR:
New insights are highlighted from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders and the roles of gender and hypomaturity in gastrointestinal responses to stress.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2017 chapter
Pathophysiology of Gastrointestinal Obstruction and Strangulation
In The Equine Acute Abdomen (pp. 102–118).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2017 journal article
Porcine Esophageal Submucosal Gland Culture Model Shows Capacity for Proliferation and Differentiation
Cellular and Molecular Gastroenterology and Hepatology, 4(3), 385–404.
author keywords: Esophagus; Barrett's Esophagus; 3D Culture; Acinar Ductal Metaplasia; Adult Stem Cell
TL;DR:
The results suggest that the activated ESMG state, seen in both human disease and the authors' porcine model, may provide a source of cells to repopulate damaged epithelium in a normal manner (squamous) or abnormally (columnar epithelia).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2017 journal article
Protein biomarker of cell proliferation determines survival to discharge in cases of equine large colon volvulus
Equine Veterinary Journal, 50(4), 452–456.
author keywords: horse; large colon volvulus; immunohistochemistry; phospho-histone H3; intestine; stem cell
MeSH headings : Animals; Biomarkers; Cell Proliferation / physiology; Cohort Studies; Colonic Diseases / veterinary; Female; Gene Expression Regulation; Horse Diseases / blood; Horses; Intestinal Volvulus / metabolism; Intestinal Volvulus / pathology; Intestinal Volvulus / veterinary; Male; ROC Curve; Retrospective Studies; Survival Analysis
TL;DR:
PHH3 immunohistochemical analysis may assist in more accurate prediction of survival to hospital discharge of LCV cases and biomarkers PCNA, SOX9 and Ki-67 did not predict short-term survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 personal communication
Reply to Dr Freeman: Keep your surgical options open
Blikslager, A. T. (2017, July).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 chapter
Small Intestinal Function
In The Equine Acute Abdomen (pp. 27–40).
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2017 journal article
Supplementation of Maternal Diets with Docosahexaenoic Acid and Methylating Vitamins Impacts Growth and Development of Fetuses from Malnourished Gilts
Current Developments in Nutrition, 2(3).
Contributors: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, J. Sommer n, W. Flowers n , n , L. Gonzalez n , J. Odle n
author keywords: choline; B-vitamins; epigenetics; intrauterine growth restriction; nutrient restriction; low birth weight
TL;DR:
Despite the mobilization of maternal stores, malnourished litters displayed reduced brain development that was fully mitigated by micronutrient supplementation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2017 book
The Equine Acute Abdomen
(A. T. Blikslager, N. A. White II, J. N. Moore, & T. S. Mair, Eds.).
TL;DR:
Providing coverage of the diseases producing equine acute abdomen or colic, this text covers diagnosis, treatment, anaesthesia, surgery and intensive care.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 11, 2019
2017 journal article
Type III Interferon Restriction by Porcine Epidemic Diarrhea Virus and the Role of Viral Protein nsp1 in IRF1 Signaling
Journal of Virology, 92(4), JVI.01677–01617.
author keywords: porcine epidemic diarrhea virus; PEDV; enteric coronaviruses; type III interferons; IRF1; peroxisomes; innate immune evasion; IFN lambda; nsp1
MeSH headings : Animals; Chlorocebus aethiops; Coronavirus Infections / virology; Epithelial Cells / virology; Host-Pathogen Interactions; Immune Evasion; Interferon Regulatory Factor-1 / metabolism; Interferons / immunology; Male; Mutation; Peroxisomes / immunology; Porcine epidemic diarrhea virus / pathogenicity; Porcine epidemic diarrhea virus / physiology; Signal Transduction; Swine / virology; Vero Cells; Viral Proteins / metabolism
TL;DR:
PEDV evasion of the type III IFN response in intestinal epithelial cells is shown for the first time, and it provides valuable information on host cell-virus interactions not only for PEDV but also for other enteric viral infections in swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2017 journal article
Update on the use of cyclooxygenase-2-selective nonsteroidal anti-inflammatory drugs in horses
Journal of the American Veterinary Medical Association, 250(11), 1271–1274.
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclooxygenase 2 Inhibitors / administration & dosage; Cyclooxygenase 2 Inhibitors / therapeutic use; Drug Compounding; Horse Diseases / drug therapy; Horses; Species Specificity; Sulfones / administration & dosage; Sulfones / therapeutic use; Veterinary Drugs
TL;DR:
Understanding the nuances of firocoxib administration, including the importance of correct dosing and the contraindications of combining NSAIDs, and knowledge of the potential advantages of COX-2 selectivity will help veterinarians select and treat patients that could benefit from this new class of NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
784 Neonates Have a Reduced Ability to Repair Jejunal Mucosal Injury As Compared to Juveniles in a Pig Model of Ischemia/ Reperfusion Injury
Gastroenterology, 150(4), S163.
Sources: Crossref, NC State University Libraries
Added: January 25, 2020
2016 journal article
Comparison of lipopolysaccharides and soluble CD14 measurement between clinically endotoxaemic and nonendotoxaemic horses
Equine Veterinary Journal, 49(2), 155–159.
Contributors: J. Fogle n, M. Jacob n, n , A. Edwards n, B. Wagner *, K. Dean n, C. Fogle n
author keywords: horse; soluble CD14; endotoxin; sepsis; inflammation; colic
MeSH headings : Animals; Biomarkers / blood; Endotoxemia / blood; Endotoxemia / veterinary; Horse Diseases / blood; Horse Diseases / diagnosis; Horses; Lipopolysaccharide Receptors / blood; Lipopolysaccharides
TL;DR:
It is suggested that sCD14 and LPS were poor predictors of clinical endotoxaemia for the horses in this study, and further investigation is warranted to assess the utility of s CD14 measurement as a clinically useful biomarker to identify endotox aemia in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Effect of topically applied Saccharomyces boulardii on the healing of acute porcine wounds: A preliminary study
BMC Research Notes, 9(1).
Contributors: J. Partlow, n , C. Matthews, M. Law n, J. Daniels*, R. Baker *, R. Labens *
MeSH headings : Acute Disease; Analysis of Variance; Animals; Female; Host-Pathogen Interactions; Male; Pilot Projects; Prospective Studies; Saccharomyces boulardii / physiology; Skin / injuries; Skin / microbiology; Skin / physiopathology; Surface Properties; Swine; Time Factors; Wound Healing / physiology; Wounds and Injuries / microbiology; Wounds and Injuries / physiopathology
TL;DR:
Topical application of Saccharomyces boulardii does not hasten wound healing or change the wounds’ microbiome under the conditions reported in this study.
(via Semantic Scholar)
Source: ORCID
Added: September 3, 2019
2016 journal article
Exploring Product Solution Differences Due to Choice Model Selection in the Presence of Noncompensatory Decisions With Conjunctive Screening Rules
JOURNAL OF MECHANICAL DESIGN, 139(2).
TL;DR:
It is demonstrated how respondents making noncompensatory choices with conjunctive rules can lead to compensatory model estimations with distinct respondent segmentation and relative, large absolute part-worth values.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Feasibility and safety of lumbosacral epiduroscopy in the standing horse
EQUINE VETERINARY JOURNAL, 49(3), 322–328.
Contributors: B. Shrauner n, n , J. Davis n, N. Campbell n, M. Law n, M. Lustgarten n, T. Prange n
author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / surgery; Female; Horse Diseases / surgery; Horses; Lumbosacral Region / surgery; Male
TL;DR:
Lumbosacral epiduroscopy can be performed safely in sedated standing horses and may become a valuable diagnostic tool in horses with caudal back or hindlimb pain of unknown origin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Indomethacin induces increase in gastric epithelial tight junction permeability via redistribution of occludin and activation of p38 MAPK in MKN-28 Cells
Tissue Barriers, 4(3), e1187325.
author keywords: JNK; MKN-28; occludin; p38 MAPK; tight junction
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Capillary Permeability; Cell Line, Tumor; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Humans; Indomethacin / pharmacology; Mice; Mice, Inbred C57BL; Occludin / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
Data suggests that indomethacin compromises the gastric epithelial barrier via p38 MAPK inducing occludin alterations in the TJs, and Pretreatment with the p38MAPK inhibitor significantly attenuated the disruption of barrier function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Intestinal Ischemia–Reperfusion: Rooting for the SOCS?
Digestive Diseases and Sciences, 62(1), 4–6.
MeSH headings : Humans; Intestinal Mucosa; Intestines; Ischemia; Reperfusion; Reperfusion Injury
TL;DR:
It is reported that ischemic preconditioning-induced suppressor of cytokine signaling-1 (SOCS-1) activation protects the intestine from IR injury via downregulation of the Toll-like receptor 4 (TLR4) pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 18, 2019
2016 journal article
Large Animal Models: The Key to Translational Discovery in Digestive Disease Research
Cellular and Molecular Gastroenterology and Hepatology, 2(6), 716–724.
author keywords: Pig; Ischemia/Reperfusion Injury; Mucosal Repair; Tight Junction
TL;DR:
Porcine model development has taken advantage of the size of the animal, allowing increased surgical and endoscopic access, and cellular tools are providing the methodology to translate basic science findings using in-depth mechanistic analyses, holding great promise for the future of clinically relevant digestive disease research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 20, 2019
2016 journal article
Mo1253 Ductular and Proliferative Response of Esophageal Submucosal Glands in a Porcine Model of Esophageal Injury and Repair
Gastroenterology, 150(4), S679–S680.
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2016 journal article
Mo1298 Critical Contribution of Intestinal Stem Cells in the Repair of Ischemia Reperfusion Injury
Gastroenterology, 150(4), S691.
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2016 journal article
Myosin light chain kinase mediates intestinal barrier dysfunction via occludin endocytosis during anoxia/reoxygenation injury
American Journal of Physiology-Cell Physiology, 311(6), C996–C1004.
author keywords: intestinal anoxia/reoxygenation injury; tight junctions; myosin light chain kinase; Caco-2BBe1; intestinal barrier functions
MeSH headings : Animals; Caco-2 Cells; Cell Line, Tumor; Dextrans / metabolism; Endocytosis / physiology; Epithelial Cells / metabolism; Epithelial Cells / physiology; Humans; Hypoxia / metabolism; Hypoxia / physiopathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Myosin Light Chains / metabolism; Myosin-Light-Chain Kinase / metabolism; Occludin / metabolism; Permeability; Phosphorylation / physiology; Signal Transduction / physiology; Swine; Tight Junctions / metabolism; Tight Junctions / physiology
TL;DR:
It is suggested that MLCK-induced occludin endocytosis mediates intestinal epithelial barrier dysfunction during A/R injury and may be a target for the therapeutic treatment of ischemia/reperfusion injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2016 journal article
Oral Administration of Astrovirus Capsid Protein Is Sufficient To Induce Acute Diarrhea In Vivo
MBio, 7(6).
MeSH headings : Administration, Oral; Avastrovirus / pathogenicity; Capsid Proteins / administration & dosage; Capsid Proteins / toxicity; Cell Membrane / chemistry; Cytoplasm / chemistry; Diarrhea / chemically induced; Diarrhea / pathology; Intestinal Mucosa / pathology; Sodium-Hydrogen Exchangers / analysis; Turkey
TL;DR:
Oral administration of purified recombinant turkey astrovirus 2 (TAstV-2) structural (capsid) protein induces acute diarrhea, increases barrier permeability, and causes relocalization of NHE3 in the small intestine, suggesting that rotavirus may not be alone in possessing enterotoxigenic activity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science, ORCID
Added: August 6, 2018
2016 conference paper
Parametric study of a fluidic artificial muscle actuated electrohydraulic system
Proceedings of the asme conference on smart materials adaptive.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2015 journal article
27 AN IMPROVED LARGE ANIMAL MODEL FOR THE STUDY OF ADULT STEM CELLS
Reproduction, Fertility and Development, 28(2), 143.
TL;DR:
The generation of a porcine stem cell reporter line using the combination of transcription activator-like effector nucleases and somatic cell NT, which represents significant progress toward the study of adult stem cells, their progenitors, and the stem cell niche, using a large animal model with an anatomy, physiology, and ability to recapitulate human disease that overcomes the current limitations of rodent models.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2015 journal article
Characterization of discrete equine intestinal epithelial cell lineages
American Journal of Veterinary Research, 76(4), 358–366.
Contributors: L. Gonzalez n , L. Kinnin & *
MeSH headings : Animals; Cell Lineage; Colic / pathology; Colic / veterinary; Epithelial Cells / cytology; Female; Horse Diseases / pathology; Horses; Intestinal Mucosa / cytology
TL;DR:
The methodology used can enhance detection of stem cells and progenitor cells as well as postmitotic cell lineages in equine intestinal tissues and may have relevance to regenerative potential of intestinal mucosa and survival in horses with colic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target
Tissue Barriers, 3(4), e1105906.
Contributors: Y. Jin n & n
author keywords: ClC-2 chloride channel; gastrointestinal diseases; intestinal barrier function; lubiprostone; tight junctions
TL;DR:
The role of ClC-2 in intestinal barrier function during intestinal disorders, including experimental ischemia/reperfusion injury and dextran sodium sulfate (DSS)-induced inflammatory bowel disease is detailed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 18, 2019
2015 journal article
Clinical features and management of equine post operative ileus (POI): Survey of Diplomates of the American Colleges of Veterinary Internal Medicine (ACVIM), Veterinary Surgeons (ACVS) and Veterinary Emergency and Critical Care (ACVECC)
Equine Veterinary Journal, 48(6), 714–719.
Contributors: D. Lefebvre*, N. Hudson*, Y. Elce *, n , T. Divers *, I. Handel *, W. Tremaine *, R. Pirie *
author keywords: horse; ileus; colic; lidocaine; intestine
MeSH headings : Animals; Colic / surgery; Colic / veterinary; Cross-Sectional Studies; Data Collection; Horse Diseases / diagnosis; Horse Diseases / etiology; Horses; Intestinal Pseudo-Obstruction / etiology; Intestinal Pseudo-Obstruction / therapy; Intestinal Pseudo-Obstruction / veterinary; Intestine, Small / pathology; Postoperative Complications / diagnosis; Postoperative Complications / therapy; Postoperative Complications / veterinary; Surveys and Questionnaires; United States; Veterinarians
TL;DR:
It was concluded that further comparative analysis of opinions, canvassed from additional colleges of equine veterinary specialism worldwide, would provide valuable additional insight into current POI knowledge on a more global scale.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy
EQUINE VETERINARY JOURNAL, 48(1), 125–129.
Contributors: T. Prange n, B. Shrauner n & n
author keywords: horse; back pain; hindlimb lameness; spinal nerve; epiduroscopy; endoscopy
MeSH headings : Animals; Cadaver; Endoscopy / methods; Endoscopy / veterinary; Epidural Space / anatomy & histology; Horses / anatomy & histology; Lumbosacral Region / anatomy & histology
TL;DR:
Lumbosacral epiduroscopy is technically feasible in standing horses and may become a valuable diagnostic tool in horses with caudal back or limb pain of unknown origin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 personal communication
Epiduroscopy of the lumbosacral vertebral canal in the horse: Technique and endoscopic anatomy Response
Prange, T., Shrauner, B. D., & Blikslager, A. T. (2016, January).
Contributors: T. Prange*, B. Shrauner* & *
MeSH headings : Animals; Endoscopy; Horses; Lumbar Vertebrae; Lumbosacral Region; Spinal Canal
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 article
Gastric impaction and large colon volvulus: Can one lead to the other?
Blikslager, A. T. (2015, September). EQUINE VETERINARY EDUCATION, Vol. 27, pp. 460–461.
author keywords: horse; colic; gastric impaction; large colon volvulus; microbiota
TL;DR:
The possibility of stomach impaction resulting in large colon volvulus is raised by authors reporting the findings of both lesions in 7 horses, and it is interesting to speculate on the possible roles of gas accumulation or other changes in the intracolonic environment, such as composition in microbiota.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Genetic Ablation of the ClC-2 Cl- Channel Disrupts Mouse Gastric Parietal Cell Acid Secretion
PLOS ONE, 10(9), e0138174.
Ed(s): A. Guerrero-Hernandez
MeSH headings : Animals; Biological Transport; CLC-2 Chloride Channels; Cell Count; Chloride Channels / genetics; Cytoplasmic Vesicles / metabolism; Digestion / genetics; Digestion / physiology; Fluorescent Antibody Technique; Gastric Acid / metabolism; H(+)-K(+)-Exchanging ATPase / biosynthesis; H(+)-K(+)-Exchanging ATPase / metabolism; Mice; Mice, Knockout; Microscopy, Electron; Parietal Cells, Gastric / metabolism; Parietal Cells, Gastric / ultrastructure; Pepsinogen A / metabolism
TL;DR:
Genetic ablation of ClC-2 resulted in reduced gastric gland region, reduced parietal cell number, reduced H/K ATPase, reduced tubulovesicles and reduced stimulated acid secretion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Pharmaceutical Activation or Genetic Absence of ClC-2 Alters Tight Junctions During Experimental Colitis
Inflammatory Bowel Diseases, 21(12), 2747–2757.
Contributors: Y. Jin n , T. Pridgen n & n
author keywords: ClC-2 chloride channel; lubiprostone; tight junctions; inflammatory bowel diseases; intestinal barrier function
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Chloride Channel Agonists / pharmacology; Chloride Channels / deficiency; Chloride Channels / drug effects; Colitis / chemically induced; Colitis / drug therapy; Colitis / genetics; Dextran Sulfate; Fluorescent Antibody Technique; Intestinal Mucosa / metabolism; Intestines / drug effects; Lubiprostone / pharmacology; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Permeability / drug effects; Tight Junction Proteins / metabolism; Tight Junctions / drug effects; Tight Junctions / metabolism; Trinitrobenzenes
TL;DR:
A central role for ClC-2 in restoration of barrier function and tight junction architecture in experimental murine colitis is suggested, which can be therapeutically targeted with lubiprostone.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Porcine models of digestive disease: the future of large animal translational research
Translational Research, 166(1), 12–27.
Contributors: L. Gonzalez n , A. Moeser n & n
MeSH headings : Animals; Animals, Genetically Modified; Digestive System Diseases / etiology; Digestive System Diseases / physiopathology; Disease Models, Animal; Enterocolitis, Necrotizing / etiology; Gastrointestinal Tract / anatomy & histology; Gastrointestinal Tract / blood supply; Gastrointestinal Tract / injuries; Humans; Intestines / transplantation; Reperfusion Injury / etiology; Short Bowel Syndrome / etiology; Short Bowel Syndrome / therapy; Species Specificity; Stress, Psychological / complications; Swine; Translational Research, Biomedical; Wound Healing
TL;DR:
This review assesses currently used porcine models of gastrointestinal physiology and disease and provides a rationale for the use of these models for future translational studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries, Web Of Science
Added: August 6, 2018
2015 chapter
Surgical disorders of the large intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (5th edition, pp. 715–718). St. Louis, MO: Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: October 18, 2020
2015 chapter
Surgical disorders of the small intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (5th edition, pp. 703–707). St. Louis, MO: Elsevier.
Ed(s): B. Smith
Source: NC State University Libraries
Added: October 18, 2020
2015 article
The paradox of diarrhoeal disease and small colon obstruction
Blikslager, A. T. (2016, August). EQUINE VETERINARY EDUCATION, Vol. 28, pp. 424–425.
author keywords: horse; colic; ulcerative colitis; fibrosis; stricture; impaction
TL;DR:
The interesting finding of stenosis in a case series of 3 foals that initially presented with diarrhoeal disease is suggestive of an inflammatory and fibrotic event that is more frequently reported in people with inflammatory bowel disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Animal models of ischemia-reperfusion-induced intestinal injury: progress and promise for translational research
American Journal of Physiology-Gastrointestinal and Liver Physiology, 308(2), G63–G75.
Contributors: L. Gonzalez n , A. Moeser n & n
author keywords: animal model; intestine; ischemia; mucosal injury; reperfusion
MeSH headings : Animals; Disease Models, Animal; Humans; Intestines / injuries; Intestines / pathology; Ischemia / complications; Ischemia / pathology; Oxygen / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Reperfusion Injury / pathology; Translational Research, Biomedical / methods
TL;DR:
This review assesses animal models of ischemia-reperfusion injury as well as the knowledge that has been derived from each to aid selection of appropriate research models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Bovine immunoglobulin protein isolates for the nutritional management of enteropathy
World Journal of Gastroenterology, 20(33), 11713.
author keywords: Immunoglobulins; Plasma proteins; Inflammation; Gut barrier; Diarrhea; Malabsorption; Treatment; Nutrition
MeSH headings : Administration, Oral; Animals; Dietary Proteins / administration & dosage; Dietary Proteins / adverse effects; Humans; Immunoglobulins / administration & dosage; Immunoglobulins / adverse effects; Inflammation Mediators / metabolism; Intestinal Absorption; Intestinal Diseases / diagnosis; Intestinal Diseases / immunology; Intestinal Diseases / metabolism; Intestinal Diseases / microbiology; Intestinal Diseases / physiopathology; Intestinal Diseases / therapy; Intestinal Mucosa / metabolism; Intestines / immunology; Intestines / microbiology; Intestines / physiopathology; Microbiota; Nutritional Status; Nutritional Support / adverse effects; Nutritional Support / methods; Permeability; Treatment Outcome
TL;DR:
Preclinical and clinical studies with plasma/serum protein concentrates supported the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 3, 2019
2014 journal article
Mo1960 Intestinal Epithelial Cells Expressing Biomarkers of Crypt Base Columnar or Reserve Stem Cells Show Differential Resistance to Ischemia-Reperfusion Injury
Gastroenterology, 146(5), S-702.
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2014 journal article
Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013
Equine Veterinary Journal, 47(3), 279–284.
Contributors: L. Gonzalez n , C. Fogle n , W. Baker, F. Hughes*, J. Law n, A. Motsinger-Reif n, n
author keywords: horse; large colon volvulus; strangulation; pelvic flexure; surgery
MeSH headings : Animals; Biopsy; Colon / pathology; Hemorrhage / pathology; Hemorrhage / veterinary; Horse Diseases / surgery; Horses; Intestinal Volvulus / pathology; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Logistic Models; Retrospective Studies
TL;DR:
Histomorphometric measurements of interstitium-to-crypt ratio and degree of haemorrhage predict short-term outcome in cases of large colon volvulus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Pharmacokinetics and pharmacodynamics of three formulations of firocoxib in healthy horses
Journal of Veterinary Pharmacology and Therapeutics, 38(3), 249–256.
Contributors: B. Holland n, C. Fogle n , n , A. Curling n, B. Barlow n, J. Schirmer n, J. Davis n
MeSH headings : 4-Butyrolactone / administration & dosage; 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / blood; 4-Butyrolactone / pharmacokinetics; 4-Butyrolactone / pharmacology; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cross-Over Studies; Dinoprostone / blood; Horses / metabolism; Injections, Intravenous / veterinary; Ointments; Sulfones / administration & dosage; Sulfones / blood; Sulfones / pharmacokinetics; Sulfones / pharmacology; Tablets; Thromboxane B2 / blood
TL;DR:
This study indicates a lack of bioequivalence between the oral formulations of firocoxib when administered as a single dose to healthy horses, as well as a higher Cmax, shorter Tmax, and greater AUC for the paste compared to the tablet.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Su1947 Genetic Absence of Chloride Channel CLC-2 Results in Disruption of Organization and Function of Murine Gastric Glands
Gastroenterology, 146(5), S-505-S-506.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 24, 2020
2014 journal article
The Effect of Tramadol and Indomethacin Coadministration on Gastric Barrier Function in Dogs
Journal of Veterinary Internal Medicine, 28(3), 793–798.
Contributors: T. Hill *, B. Lascelles n, J. Law n & n
author keywords: NSAID; tramadol; ulcer
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Dinoprostone / analysis; Dogs; Drug Therapy, Combination; Gastric Mucosa / chemistry; Gastric Mucosa / drug effects; Gastric Mucosa / physiology; Indomethacin / administration & dosage; Indomethacin / pharmacology; Thromboxane B2 / analysis; Tramadol / administration & dosage; Tramadol / pharmacology
TL;DR:
The results suggest that if there is an adverse interaction of the 2 drugs in vivo, it is unlikely to be via prostanoid inhibition, and could be via nonselective cyclooxygenase inhibition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
The use of nonsteroidal anti-inflammatory drugs in critically ill horses
Journal of Veterinary Emergency and Critical Care, 25(1), 76–88.
author keywords: analgesia; antiendotoxin; drug therapy; equine; side-effects
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Critical Care; Critical Illness; Cyclooxygenase 2 / administration & dosage; Cyclooxygenase 2 / adverse effects; Cyclooxygenase 2 / therapeutic use; Gastrointestinal Tract / drug effects; Horse Diseases / drug therapy; Horses; Humans; Kidney / drug effects; Pain / drug therapy; Pain / veterinary; Veterinary Medicine
TL;DR:
The physiology of the cyclooxygenase (COX) enzymes with reference to the beneficial effects of nonsteroidal anti-inflammatory drugs related to their analgesic and antiendotoxic properties as well as the mechanisms responsible for adverse gastrointestinal, renal, and coagulation effects are reviewed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Tu2028 Lubiprostone reduces murine colitis principally in a ClC-2-dependent manner.
Gastroenterology, 146(5), S-901.
Sources: Crossref, NC State University Libraries, ORCID
Added: February 11, 2019
2013 journal article
Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets
World Journal of Gastroenterology, 19(31), 5094–5102.
Contributors: S. Jacobi n, A. Moeser, , J. Rhoads, B. Corl, R. Harrell, J. Odle
author keywords: Rotavirus gastroenteritis; Kwashiorkor; Occludin; Ussing chamber; Villus
MeSH headings : Animals; Animals, Newborn; Diarrhea / metabolism; Diarrhea / virology; Disease Models, Animal; Electric Impedance; Humans; Infant Formula / metabolism; Infant, Newborn; Intestinal Absorption; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Mannitol / metabolism; Occludin / metabolism; Permeability; Protein-Energy Malnutrition / metabolism; Protein-Energy Malnutrition / pathology; Protein-Energy Malnutrition / virology; Rotavirus Infections / metabolism; Rotavirus Infections / pathology; Rotavirus Infections / virology; Swine; Tight Junctions / metabolism; Tight Junctions / virology; Time Factors; Weight Loss
TL;DR:
Overall, malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2013 journal article
Cell Lineage Identification and Stem Cell Culture in a Porcine Model for the Study of Intestinal Epithelial Regeneration
PLoS ONE, 8(6), e66465.
Contributors: L. Gonzalez n , I. Williamson *, J. Piedrahita n , n & S. Magness *
Ed(s): S. Singh
MeSH headings : Animals; Apoptosis; Biomarkers / metabolism; Cell Culture Techniques; Cell Cycle; Cell Differentiation; Cell Lineage; Cell Proliferation; Cells, Cultured; Epithelial Cells / physiology; Epithelial Cells / ultrastructure; Goblet Cells / physiology; Goblet Cells / ultrastructure; Intestinal Mucosa / physiology; Intestinal Mucosa / ultrastructure; Regeneration; Stem Cells / physiology; Sus scrofa
TL;DR:
Biomarker characterization and development of IESC culture in the porcine model represents a foundation for translational studies of I ESC-driven regeneration of the intestinal epithelium in physiology and disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2013 journal article
Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis
Inflammatory Bowel Diseases, 19(13), 2867–2877.
Contributors: P. Nighot n, K. Young n, M. Nighot n, M. Rawat *, E. Sung n, N. Maharshak *, S. Plevy*, T. Ma *, n
author keywords: inflammatory bowel disease; barrier function; tight junction
MeSH headings : Animals; Blotting, Western; CLC-2 Chloride Channels; Caco-2 Cells; Chloride Channels / physiology; Colitis / chemically induced; Colitis / metabolism; Colitis / pathology; Cytokines / metabolism; Dextran Sulfate / toxicity; Disease Models, Animal; Female; Humans; Immunoenzyme Techniques; Intestinal Mucosa / injuries; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tight Junctions / metabolism; Tight Junctions / pathology
TL;DR:
ClC-2 plays a critical role in experimental colitis in that its absence increases disease activity, reduces barrier function and recovery, and perturbs TJs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Ex vivo effect of gold nanoparticles on porcine synovial membrane
Tissue Barriers, 1(2), e24314.
author keywords: gold; nanoparticles; nanogold; synovium; permeability; synovitis; arthritis; ussing; ex vivo
TL;DR:
Results with ex vivo tissue modeling of porcine synovium support an anti-inflammatory effect of AuNPs warranting further investigation, and exposure to pro-inflammatory factors did not significantly affect AuNP permeation or biomarker levels in this model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: July 27, 2019
2013 journal article
Feeding intravenously saves the patient but starves the gut: consequences for the intestinal barrier
The Journal of Physiology, 591(15), 3673–3673.
MeSH headings : Animals; Intestinal Mucosa / physiopathology; Male; Parenteral Nutrition, Total / adverse effects; Receptors, Tumor Necrosis Factor, Type I / physiology; Receptors, Tumor Necrosis Factor, Type II / physiology; Tumor Necrosis Factor-alpha / physiology
TL;DR:
Feng & Teitelbaum (2013) have built on their previous findings of barrier disruption in experimental animals on TPN by showing that a complex interplay of tumour necrosis factor (TNFα) and its two receptors (TNFR1 and TNFR2) is responsible for the breakdown of intestinal epithelial tight junctions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Su1099 A Translational Porcine Model of Intestinal Stem Cells
Gastroenterology, 144(5), S-398.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: February 5, 2020
2013 journal article
Tu1641 Effects of Lubiprostone in a Porcine Model of Stress-Induced Intestinal Barrier Injury
Gastroenterology, 144(5), S-812-S-813.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2013 journal article
Validation of a photogrammetric technique for computing equine hoof volume
VETERINARY JOURNAL, 197(3), 625–630.
Contributors: R. Labens n, W. Redding n, K. Desai n, K. Vom Orde, R. Mansmann n & n
author keywords: Equine; Foot volume; Finite element analysis; Photogrammetry
MeSH headings : Animals; Hoof and Claw / anatomy & histology; Horses / anatomy & histology; Image Processing, Computer-Assisted / methods; Photogrammetry / methods; Photogrammetry / veterinary
TL;DR:
Pre-trim photogrammetric measurements showed excellent precision and accuracy and the results did not depend on the person acquiring the images, but average differences in foot volume after trimming are likely too small to be detected with confidence.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
211 Chloride Channel CLC-2 Mediated Tight Junction Barrier Function Modulates DSS-Induced Murine Colitis
Gastroenterology, 142(5), S-52.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2012 journal article
Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection
Comparative Immunology, Microbiology and Infectious Diseases, 35(1), 63–69.
Contributors: R. Meyerhoff n, P. Nighot n, R. Ali n, n & M. Koci n
author keywords: Astrovirus; Enterocyte; Turkey; Inducible nitric oxide; Innate immunity
MeSH headings : Amino Acid Sequence; Animals; Astroviridae Infections / enzymology; Astroviridae Infections / veterinary; Astroviridae Infections / virology; Avastrovirus / physiology; Avian Proteins / genetics; Avian Proteins / metabolism; Bird Diseases / enzymology; Bird Diseases / virology; Enterocytes / enzymology; Enterocytes / pathology; Enterocytes / virology; Gene Expression; HEK293 Cells; Humans; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestinal Mucosa / virology; Lentivirus / genetics; Molecular Sequence Data; Nitric Oxide / biosynthesis; Nitric Oxide Synthase Type II / genetics; Nitric Oxide Synthase Type II / metabolism; Phylogeny; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Transfection; Turkeys
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors
BMC Pharmacology, 12(1).
Contributors: J. Cuppoletti*, n , J. Chakrabarti *, P. Nighot n & D. Malinowska*
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Animals; Calcium / physiology; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Epithelial Cells / drug effects; Epithelial Cells / physiology; Female; Gastrointestinal Agents / pharmacology; Homeostasis / drug effects; Humans; In Vitro Techniques; Interferon-gamma / pharmacology; Ischemia / physiopathology; Jejunum / drug effects; Jejunum / physiology; Lubiprostone; Male; Membrane Potentials / drug effects; Occludin / metabolism; Peptides / pharmacology; Swine; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
The finding that lubiprostone, but not active linaclotide, exhibits the additional distinct property of effective protection or repair of the epithelial barrier and cell function after stress suggests potential clinical importance for patients with impaired or compromised barrier function such as might occur in IBS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: July 27, 2019
2012 journal article
Dietary Long-Chain PUFA Enhance Acute Repair of Ischemia-Injured Intestine of Suckling Pigs
The Journal of Nutrition, 142(7), 1266–1271.
Contributors: S. Jacobi n, A. Moeser n, B. Corl n, R. Harrell n, n & J. Odle n
MeSH headings : Animals; Constriction; Diet; Dietary Fats / pharmacology; Dietary Supplements; Eicosapentaenoic Acid / pharmacology; Electric Impedance; Ileal Diseases / drug therapy; Ileal Diseases / pathology; Ileal Diseases / physiopathology; Ileum / drug effects; Ileum / pathology; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / blood; Ischemia / drug therapy; Ischemia / pathology; Ischemia / physiopathology; Mannitol / blood; Mesentery / blood supply; Swine; Wound Healing / drug effects
TL;DR:
It is demonstrated that feeding elevated levels of long-chain PUFA enhances acute recovery of ischemia-injured porcine ileum, and a histological evaluation of ischemic ilea from piglets fed the 5% ARA showed reduced histological lesions after ischemIA compared with the other dietary groups.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Effect of a zincl-carnosine compound on acid-induced injury in canine gastric mucosa ex vivo
American Journal of Veterinary Research, 73(5), 659–663.
Contributors: T. Hill n & *
MeSH headings : Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Carnosine / administration & dosage; Carnosine / analogs & derivatives; Caspase 3 / chemistry; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dog Diseases / prevention & control; Dogs; Fluorescent Antibody Technique / veterinary; Gastric Acid / chemistry; Gastric Mucosa / drug effects; Gastric Mucosa / pathology; Hydrogen-Ion Concentration; In Vitro Techniques; Isotonic Solutions / chemistry; Organometallic Compounds / administration & dosage; Ringer's Solution; Stomach Ulcer / chemically induced; Stomach Ulcer / drug therapy; Stomach Ulcer / prevention & control; Stomach Ulcer / veterinary; Vitamin E / administration & dosage; Vitamin E / pharmacology; Zinc Compounds / administration & dosage
TL;DR:
Addition of HCl caused a dose-dependent increase in gastric permeability over time and apparent induction of apoptosis as determined on the basis of immunofluorescence, which suggested the utility of this method for further studies of canine gastric injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa
World Journal of Gastroenterology, 18(34), 4684–4692.
Contributors: M. Nighot n, A. Moeser n, R. Ueno * & n
author keywords: Stomach; Mucosal permeability; ClC-2 chloride channel; Tight junction
MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channel Agonists; Chloride Channels / analysis; Cystic Fibrosis Transmembrane Conductance Regulator / analysis; Electric Impedance; Gastric Mucosa / drug effects; Mannitol / metabolism; Microscopy, Fluorescence; Permeability; Prostaglandins / pharmacology; Swine
TL;DR:
ClC-2 agonist SPI-8811 stimulated enhancement of mucosal barrier function by protecting TJ protein occludin in porcine gastric mucosa and thus protected the gastric acid injury in porCine stomach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 3, 2019
2012 book
Gastroduodenal Ulceration
In Small Animal Soft Tissue Surgery (pp. 329–340).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: January 22, 2019
2012 journal article
Misoprostol: Is it safety or a lack of understanding that prevents its more frequent usage?
Equine Veterinary Journal, 45(1), 8–8.
MeSH headings : Animals; Anti-Ulcer Agents / adverse effects; Anti-Ulcer Agents / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Misoprostol / adverse effects; Misoprostol / therapeutic use; Pregnancy; Ulcer / drug therapy; Ulcer / veterinary
TL;DR:
The present manuscript provides strong evidence that misoprostol can be used safely and, more to the point, it is a viable option for mares with evidence of gastrointestinal mucosal injury and based on experimental evidence in horses with small intestinal ischaemic injury and evidence of success in nonsteroidal anti-inflammatory drug (NSAID)-induced colitis, misop frostol may be deserving of further studies for hastening mucosal repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Pain management in horses | Schmerzmanagement beim Pferd
Praktische Tierarzt, 93(3), 223–226. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879328604&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2012 journal article
Precision of a photogrammetric method to perform 3D wound measurements compared to standard 2D photographic techniques in the horse
Equine Veterinary Journal, 45(1), 41–46.
Contributors: R. Labens n & n
author keywords: horse; wound; photogrammetry
MeSH headings : Animals; Horse Diseases / pathology; Horses / injuries; Image Processing, Computer-Assisted / instrumentation; Image Processing, Computer-Assisted / methods; Photography; Wound Healing / physiology; Wounds and Injuries / pathology; Wounds and Injuries / veterinary
TL;DR:
The intraoperator repeatability of 3D wound measurements based on principles of stereophotogrammetry is significantly increased compared to that of a standard 2D photographic technique indicating it may be a useful diagnostic and monitoring tool.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Return to use and performance following exploratory celiotomy for colic in horses: 195 cases (2003-2010)
Equine Veterinary Journal, 45(2), 224–228.
author keywords: horse; colic; surgery; prognosis; performance
MeSH headings : Animals; Colic / surgery; Colic / veterinary; Female; Horse Diseases / surgery; Horses; Logistic Models; Male; Odds Ratio; Postoperative Complications
TL;DR:
Targeted owner education regarding preoperative lameness, post operative rehabilitation and treatment for complications, such as incisional hernioplasty, may help inform owners about their horse's potential for return to use and performance following colic surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
4. Quality Education
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2012 journal article
Su1738 Misoprostol Protects Gastric Barrier Function After Acid Injury in an Ex Vivo Canine Model
Gastroenterology, 142(5), S-492.
Sources: Crossref, NC State University Libraries, ORCID
Added: January 22, 2019
2012 journal article
Su1751 The CLC-2 Agonist SPI-0811 Protects Against Indomethacin-Induced Epithelial Barrier Dysfunction in Human Gastric Epithelial Cells
Gastroenterology, 142(5), S-495.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
Cecal impaction in horses
Compendium on Continuing Education for the Practising Veterinarian, 33(7), E1–4. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861449526&partnerID=MN8TOARS
Sources: ORCID, NC State University Libraries
Added: September 3, 2019
2011 journal article
Cecal impaction in horses.
Compendium (Yardley, PA), 33(7). http://www.scopus.com/inward/record.url?eid=2-s2.0-84879314118&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2011 journal article
Chloride Channel CLC-2 Modulates Susceptibility to DSS-Induced Murine Colitis: Implications for the Role of the Tight Junction in IBD
Gastroenterology, 140(5), S-502.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
Chloride channel ClC-2 modulates tight junction barrier function via intracellular trafficking of occludin
American Journal of Physiology-Cell Physiology, 302(1), C178–C187.
Contributors: P. Nighot n & n
author keywords: Caco-2; epithelium; intestine; permeability
MeSH headings : CLC-2 Chloride Channels; Caco-2 Cells; Caveolae / metabolism; Caveolae / physiology; Cell Communication / physiology; Chloride Channels / metabolism; Chloride Channels / physiology; Humans; Intracellular Fluid / metabolism; Intracellular Fluid / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Occludin; Protein Transport / physiology; Tight Junctions / metabolism; Tight Junctions / physiology
TL;DR:
Data indicate that ClC-2 plays an important role in the modulation of tight junctions by influencing caveolar trafficking of the tight junction protein occludin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2011 book
Colic: Diagnosis, Surgical Decision, and Preoperative Management
In Equine Surgery (pp. 402–407).
Source: ORCID
Added: September 3, 2019
2011 journal article
Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs
Journal of Veterinary Pharmacology and Therapeutics, 35(5), 452–459.
Contributors: K. Messenger n, M. Papich n & n
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Bacteria / drug effects; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Subcutaneous; Microbial Sensitivity Tests; Swine / blood
TL;DR:
It is demonstrated that the concentration of biologically active enrofloxacin in tissues exceeds the concentration predicted by the unbound fraction in pig plasma, and is sufficient for the pathogens that cause respiratory infections in pigs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2011 journal article
Evaluation of the cyclooxygenase selectivity of robenacoxib and its effect on recovery of ischemia-injured jejunal mucosa in horses
American Journal of Veterinary Research, 72(2), 226–232.
Contributors: J. Marshall n, A. Bhatnagar n, S. Bowman n, C. Howard n, N. Morris n, D. Skorich n, C. Redding n, n
MeSH headings : Animals; Cyclooxygenase 1 / metabolism; Cyclooxygenase Inhibitors / pharmacology; Cyclooxygenase Inhibitors / therapeutic use; Diphenylamine / analogs & derivatives; Diphenylamine / pharmacology; Diphenylamine / therapeutic use; Female; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / pathology; Intestinal Diseases / veterinary; Ischemia / pathology; Ischemia / veterinary; Jejunum / pathology; Phenylacetates / pharmacology; Phenylacetates / therapeutic use
TL;DR:
Robenacoxib selectively inhibited COX-2 and allowed recovery of barrier function in ischemia-injured equine jejunal tissue in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Hypoxia Disrupts Recovery of Injured Non-Transformed Small Intestinal Cells, but Not Transformed Cells
Gastroenterology, 140(5), S-699.
TL;DR:
Findings indicate that disruption of the Bach1 gene resulted in attenuation of I/R-challenged intestinal injury, indicating thathibition of Bach1 maybeanoveltherapeutic strategy for treatment against I/ R-mediatedintestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
Indomethacin Decreases Recovery of Gastric Barrier Function After Acid Injury in a Novel Ex Vivo Canine Model
Gastroenterology, 140(5), S-319.
TL;DR:
Determination of microcirculatory changes In Vivo in human is possible during conventional endoscopic procedure by using Lazma system and it helps to point out the initial stages of damage to the gastric mucosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
Indomethacin Induces Gastric Epithelial Barrier Dysfunction via a p38 MAPK-Dependent Mechanism in MKN-28 Cells
Gastroenterology, 140(5), S-315.
TL;DR:
Colonic tissue responds to IL-11 largely by activation of STAT3 signalling, which causes a large and significant increase in the expression of IL-33 and other mediators of the innate immune response in the absence of any significant damage to the mucosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 book
Principles of Intestinal Injury and Determination of Intestinal Viability
In Equine Surgery (pp. 411–416).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 3, 2019
2011 book
Source: ORCID
Added: September 3, 2019
2011 journal article
The Chloride Channel CLC-2 Modulates Tight Junction Barrier Function via Intracellular Trafficking
Gastroenterology, 140(5), S-503.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
The Chloride Channel CLC-2 is Involved in Organization of Murine Gastric Glands
Gastroenterology, 140(5), S-93.
TL;DR:
The phenotype of these two mouse models suggests that Hh signaling is necessary for the maintenance of the corpus epithelium and gastric epithelial cilia might be important for the function but not differentiation of gastrinand ghrelin-secreting cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2011 journal article
The effect of nonsteroidal anti-inflammatory drugs on the equine intestine
Equine Veterinary Journal, 43(SUPPL.39), 140–144.
Contributors: J. Marshall* & n
author keywords: horse; NSAID; intestine; injury
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Gastrointestinal Diseases / chemically induced; Gastrointestinal Diseases / veterinary; Horse Diseases / chemically induced; Horses; Intestines / drug effects
TL;DR:
Experimental evidence suggests that those NSAIDs with cyclooxygenase independent anti-inflammatory effects or a COX-2 selective mode of action may offer significant advantages over traditional NSAIDs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
The effects of a novel anti-inflammatory compound (AHI-805) on cyclooxygenase enzymes and the recovery of ischaemia injured equine jejunum ex vivo
Equine Veterinary Journal, 43(SUPPL.39), 106–111.
Contributors: J. Marshall n, A. Bhatnagar n, S. Bowman n, N. Morris n, D. Skorich n, C. Redding n, n
TL;DR:
Flunixin meglumine and AHI-805 inhibit recovery of barrier function in ischaemic-injured equine jejunum in vitro through inhibition of the COX enzymes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Ultrastructural changes in the equine colonic mucosa after ischaemia and reperfusion
Equine Veterinary Journal, 43(SUPPL.39), 8–15.
Contributors: A. Grosche*, A. Morton*, A. Graham*, L. Sanchez *, n , M. Polyak *, D. Freeman *
author keywords: horse; colon; TEM; tight junctions; autophagy; phagocytosis; immune cells
MeSH headings : Animals; Colon / pathology; Colon / ultrastructure; Colonic Diseases / pathology; Colonic Diseases / veterinary; Horse Diseases / pathology; Horses; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR:
The morphology and ultrastructural changes in the epithelium in equine large colonic mucosa after I/R, and the response of inflammatory cells to injury are described to provide information on early changes in barrier properties, repair and inflammation in Equine colon after ischaemia and reperfusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
580 Intestinal Epithelial Barrier Alterations in CLC-2−/− Mice are Partially Regulated by MLCK
Gastroenterology, 138(5), S-82.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2010 journal article
A surgical tendonitis model in horses: Technique, clinical, ultrasonographic and histological characterisation
Veterinary and Comparative Orthopaedics and Traumatology, 23(4), 231–239.
Contributors: M. Schramme n, S. Hunter *, N. Campbell*, * & R. Smith *
author keywords: Surgical model; tendonitis; horse; superficial digital flexor tendon
MeSH headings : Anesthesia, General / veterinary; Animals; Euthanasia, Animal; Follow-Up Studies; Forelimb / surgery; Horse Diseases / diagnostic imaging; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Postoperative Care / veterinary; Tendinopathy / diagnostic imaging; Tendinopathy / pathology; Tendinopathy / surgery; Tendinopathy / veterinary; Time Factors; Treatment Outcome; Ultrasonography / veterinary
TL;DR:
The reported surgical technique resulted in core lesions that were consistent in size and location, were readily evaluated with ultrasonography, and showed similarities with the ultrasonographic and histological progression of naturally occurring tendonitis lesions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 3, 2019
2010 book
Alimentary diseases
In Diagnostic Techniques in Equine Medicine: Second Edition (pp. 28–72). http://www.scopus.com/inward/record.url?eid=2-s2.0-84905885831&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2010 journal article
Astrovirus infection induces sodium malabsorption and redistributes sodium hydrogen exchanger expression
Virology, 401(2), 146–154.
author keywords: Astrovirus; Viral enteritis; Malabsorption diarrhea; Sodium/hydrogen exchanger; Intestinal electrophysiology; Turkey
MeSH headings : Actins / metabolism; Animals; Astroviridae Infections / pathology; Astroviridae Infections / veterinary; Avastrovirus / pathogenicity; Cell Membrane / chemistry; Cytoplasm / chemistry; Gene Expression; Intestinal Mucosa / pathology; Intestinal Mucosa / ultrastructure; Poultry Diseases / pathology; Poultry Diseases / virology; Sodium / metabolism; Sodium-Hydrogen Exchangers / analysis; Turkeys
TL;DR:
Data suggest astrovirus infection induces sodium malabsorption, possibly through redistribution of specific sodium transporters, which results in the development of an osmotic diarrhoea in infants and the immunocompromised.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
ClC-2 regulates mucosal barrier function associated with structural changes to the villus and epithelial tight junction
American Journal of Physiology-Gastrointestinal and Liver Physiology, 299(2), G449–G456.
Contributors: P. Nighot n & n
author keywords: myosin light chain kinase; chloride channel; mannitol flux
MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / antagonists & inhibitors; Chloride Channels / deficiency; Chloride Channels / metabolism; Chlorides / pharmacology; Electrophysiological Phenomena; Ileum / drug effects; Ileum / metabolism; Ileum / physiology; Ileum / ultrastructure; In Vitro Techniques; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiology; Intestinal Mucosa / ultrastructure; Mannitol / pharmacokinetics; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Electron, Scanning; Microvilli / ultrastructure; Myosin-Light-Chain Kinase / metabolism; Permeability; Phenotype; Tight Junctions / ultrastructure; Zinc Compounds / pharmacology
TL;DR:
It is indicated that ClC-2 reduces barrier function in normal mucosa, and the mechanisms underlying these differing roles are not entirely clear, although ultrastructural morphology of tight junctions and MLCK appear to be important to the function of ClC -2 innormal mucosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Demographic characteristics of horses donated to the North Carolina State University Equine Health Center, 1996–2008
Journal of the American Veterinary Medical Association, 236(12), 1334–1337.
Contributors: S. Bowman n, J. Marshall* & *
MeSH headings : Animals; Cohort Studies; Demography; Education, Veterinary; Female; Horse Diseases / epidemiology; Horses; Male; North Carolina; Retrospective Studies; Universities
TL;DR:
The most common reason given for unwanted horses offered for donation during 2007 and 2008 was musculoskeletal disease, with degenerative joint disease, lameness of undetermined cause, laminitis, and navicular disease being the most common musculosity conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Dr Peter Rossdale, OBE, Editor Equine Veterinary Journal 1980-2010
Equine Veterinary Journal, 43(1), 2–2.
Contributors: n , R. Christley *, L. Jeffcott *, I. Silver * & R. Weeren *
MeSH headings : Editorial Policies; History, 20th Century; History, 21st Century; Periodicals as Topic / history
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2010 journal article
Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum | Wirkung von firocoxib oder flunixin auf die regeneration des ischämisch geschädigtem jejunum beim pferd
Pferdeheilkunde, 26(1), 100–101. http://www.scopus.com/inward/record.url?eid=2-s2.0-77749270496&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2010 journal article
Evaluation of the relationship between lesions in the gastroduodenal region and cyclooxygenase expression in clinically normal dogs
American Journal of Veterinary Research, 71(6), 630–635.
Contributors: J. Wooten n, B. Lascelles n, V. Cook*, J. Law n & n
MeSH headings : Animals; Blotting, Western / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dog Diseases / enzymology; Dog Diseases / pathology; Dogs / metabolism; Duodenitis / enzymology; Duodenitis / pathology; Duodenitis / veterinary; Duodenum / enzymology; Duodenum / pathology; Female; Gastritis / enzymology; Gastritis / pathology; Gastritis / veterinary; Immunohistochemistry / veterinary; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Male; Pylorus / enzymology; Pylorus / pathology; Statistics, Nonparametric
TL;DR:
Dogs that appear to be clinically normal may have underlying gastroduodenal lesions associated with upregulation of COX-2, and practitioners should be aware of this potential situation when prescribing COX inhibitors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Ischemic disorders of the intestinal tract
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd edition, pp. 876–882). St. Louis, MO: Saunders Elsevier.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: October 18, 2020
2010 journal article
Long Toes in the Hind Feet and Pain in the Gluteal Region: An Observational Study of 77 Horses
JOURNAL OF EQUINE VETERINARY SCIENCE, 30(12), 720–726.
Contributors: R. Mansmann n, S. James n, n & K. Orde n
author keywords: Horse; foot; Hoof; Toe; Gluteal; Pain
TL;DR:
The conclusion is that excessive toe length in the hind feet may be accompanied by pain in the gluteal region and, in the experience, may be associated with gait or performance problems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
M1863 Indomethacin Impedes Recovery From Hypoxia-Reoxygenation in CACO-2 Cells
Gastroenterology, 138(5), S-434.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2010 journal article
Mucosal epithelial barrier repair to maintain pig health
Livestock Science, 133(1-3), 194–199.
author keywords: Restitution; Tight junction; Villus contraction; Epithelium; Sepsis
TL;DR:
Mucosal barrier function is critical to prevent translocation of microorganisms and their toxins and the prominent contribution of the paracellular space to measures of barrier function such as transepithelial electrical resistance is highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 3, 2019
2010 chapter
Obstructive disorders of the gastrointestinal tract
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd edition, pp. 882–892). St. Louis, MO: Saunders Elsevier.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: October 18, 2020
2010 chapter
Pathophysiology of mucosal injury and repair
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (3rd edition, pp. 794–802). St. Louis, MO: Saunders Elsevier.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: October 18, 2020
2010 journal article
TL;DR:
The authors have developed the interesting hypothesis that infiltration of eosinophils ultimately leads to muscular hypertrophy of the intestinal wall, followed by formation of diverticulae, and the notion that surgery is not indicated in certain cases of peritonitis should be dismissed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Primary gastric impaction in horses: A retrospective study of 20 cases (2005-2008)
EQUINE VETERINARY EDUCATION, 23(4), 186–190.
Contributors: K. Vainio, B. Sykes * & n
author keywords: horse; gastric impaction; enteral fluid therapy; gastroscopy; gastric ulceration
TL;DR:
This is the largest group of horses reported that were treated with enteral fluid therapy for a gastric impaction and it was concluded that enteral fluids therapy was of value in this study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
S1779 The Chloride Channel CLC-2 Modulates Early Barrier Development in CACO-2 Cells
Gastroenterology, 138(5), S-272.
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2010 journal article
TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium
The Journal of Immunology, 185(8), 4729–4737.
Contributors: R. Kajino-Sakamoto n, E. Omori n, P. Nighot n, n , K. Matsumoto * & J. Ninomiya-Tsuji n
MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
TL;DR:
It is reported that TGF-β–activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium and regulates ROS through transcription factor NF-E2–related factor 2, which is important for intestinal epithelial integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
The pharmacokinetics and in vitro cyclooxygenase selectivity of deracoxib in horses
Journal of Veterinary Pharmacology and Therapeutics, 34(1), 12–16.
Contributors: J. Davis*, J. Marshall*, M. Papich n , * & N. Campbell n
MeSH headings : Animals; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Horses / blood; Horses / metabolism; Sulfonamides / blood; Sulfonamides / pharmacokinetics; Sulfonamides / pharmacology
TL;DR:
It is shown that deracoxib is absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in the dog and horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
665 The Role of the Intestinal Microbiota in Colonic Barrier Dysfunction Induced By Neonatal Stress
Gastroenterology, 136(5), A-102.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2009 chapter
Alimentary diseases
In F. G. R. Taylor, T. Brazil, & M. H. Hillyer (Eds.), Diagnostic Techniques in Equine Medicine (2nd ed., pp. 27–72).
Ed(s): F. Taylor, T. Brazil & M. Hillyer
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 5, 2020
2009 journal article
Anti-inflammatory effects of intravenously administered lidocaine hydrochloride on ischemia-injured jejunum in horses
American Journal of Veterinary Research, 70(10), 1259–1268.
Contributors: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n, J. Marshall n, n
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / adverse effects; Clonixin / analogs & derivatives; Female; Gene Expression Regulation, Enzymologic / drug effects; Horse Diseases / chemically induced; Horse Diseases / drug therapy; Horses; Intestinal Diseases / chemically induced; Intestinal Diseases / veterinary; Ischemia / chemically induced; Jejunum / drug effects; Lidocaine / therapeutic use; Male; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / metabolism
TL;DR:
In horses with ischemia-injured jejunum, lidocaine administered IV reduced plasma prostaglandin E(2) metabolite concentration and mucosal COX-2 expression and coadministration of lidocane with flunixin ameliorated the flunxin-induced increase in mucosal neutrophil counts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 chapter
Cecal impaction
In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th edition, pp. 405–407). St. Louis: Saunders Elsevier.
Ed(s): N. Robinson & K. Sprayberry
Source: NC State University Libraries
Added: October 18, 2020
2009 journal article
Early weaning stress impairs development of mucosal barrier function in the porcine intestine
American Journal of Physiology-Gastrointestinal and Liver Physiology, 298(3), G352–G363.
author keywords: weaning age; mast cells; corticotropin releasing factor
MeSH headings : Animals; Animals, Newborn; Barium Compounds / pharmacology; Cell Count; Chlorides / pharmacology; Corticotropin-Releasing Hormone / blood; Corticotropin-Releasing Hormone / metabolism; Corticotropin-Releasing Hormone / pharmacology; Cromolyn Sodium / pharmacology; Electric Impedance; Electrophysiological Phenomena / drug effects; Electrophysiological Phenomena / physiology; Female; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / metabolism; Ion Transport / physiology; Jejunum / drug effects; Jejunum / metabolism; Jejunum / pathology; Jejunum / physiopathology; Male; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / metabolism; Mast Cells / pathology; Permeability; Potassium / metabolism; Potassium Channel Blockers / pharmacology; Protease Inhibitors / pharmacology; Receptors, Corticotropin-Releasing Hormone / antagonists & inhibitors; Receptors, Corticotropin-Releasing Hormone / metabolism; Receptors, Glucocorticoid / metabolism; Stress, Physiological / physiology; Sus scrofa; Tryptases / metabolism; Weaning
TL;DR:
It is shown that stress associated with early weaning in pigs leads to impaired mucosal barrier function, and activation of mast cells ex vivo with c48/80 and corticotrophin-releasing factor induced barrier dysfunction and elevations in short-circuit current that were inhibited with mast cell protease inhibitors.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2009 journal article
Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum
American Journal of Veterinary Research, 70(8), 992–1000.
Contributors: V. Cook n, C. Meyer n, N. Campbell n & n
MeSH headings : 4-Butyrolactone / analogs & derivatives; 4-Butyrolactone / therapeutic use; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Blotting, Western / veterinary; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / metabolism; Eicosanoids / blood; Electrophoresis, Polyacrylamide Gel / veterinary; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Jejunal Diseases / drug therapy; Jejunal Diseases / veterinary; Sulfones / therapeutic use; Thromboxane B2 / blood
TL;DR:
Firocoxib may be advantageous in horses recovering from ischemic intestinal injury, while providing effective analgesia in horses treated with flunixin meglumine and firo Coxib.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs
American Journal of Veterinary Research, 70(10), 1243–1249.
Contributors: J. Wooten n, n , S. Marks n, J. Law n, E. Graeber n & B. Lascelles n
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Dogs; Drug Administration Schedule; Female; Gastric Mucosa / drug effects; Gastric Mucosa / metabolism; Gene Expression Regulation / drug effects; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism
TL;DR:
It is suggested that, for these experimental conditions, there were no differences among the preferential and selective COX-2 inhibitors with regard to adverse effects on the gastric and duodenal portions of the gastrointestinal tract of dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Expression of cyclooxygenase-1 and -2 in the left dorsal colon after different durations of ischemia and reperfusion in horses
American Journal of Veterinary Research, 70(12), 1536–1544.
Contributors: A. Morton *, A. Grosche n, A. Rötting n, S. Matyjaszek n, n & D. Freeman n
MeSH headings : Animals; Colitis, Ischemic / veterinary; Colon / blood supply; Colon / metabolism; Colon / pathology; Cyclooxygenase 1 / genetics; Cyclooxygenase 1 / metabolism; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression Regulation, Enzymologic; Horse Diseases / metabolism; Horse Diseases / pathology; Horses; Reperfusion Injury / metabolism; Reperfusion Injury / veterinary; Time Factors
TL;DR:
It is suggested that upregulation of COX-2 in surface epithelium and crypt cells following ischemic injury in equine colon may represent an early step in the repair process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
M1698 Clc-2 Regulates Mucosal Barrier Function Associated with Structural Changes to the Villus and Early Co-Localization with Occludin
Gastroenterology, 136(5), A-413.
TL;DR:
Reduction of endogenous MUC17 is associated with reduced cell adherence, aggregation, and migration and increased apoptosis in response to exogenous toxins and this correlated with increased permeability, iNOS and COX2 induction, and bacterial invasion in Response to EIEC exposure.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: March 8, 2020
2009 chapter
Non-steroidal anti-inflammatory
In N. E. Robinson & K. A. Sprayberry (Eds.), Current Therapy in Equine Medicine (6th edition, pp. 7–10). St. Louis, MO: Saunders Elsevier.
Ed(s): N. Robinson & K. Sprayberry
Source: NC State University Libraries
Added: October 18, 2020
2009 chapter
Pathophysiology of gastrointestinal disease: obstruction and strangulation
In N. A. White, J. N. Moore, & T. S. Mair (Eds.), The Equine Acute Abdomen (pp. 100–107). Jackson, WY: Teton New Media.
Ed(s): N. White, J. Moore & T. Mair
Source: NC State University Libraries
Added: October 18, 2020
2009 chapter
Surgical disorders of the large intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (4th edition, pp. 750–755). St. Louis, MO: Mosby.
Ed(s): B. Smith
Source: NC State University Libraries
Added: February 20, 2021
2009 chapter
Surgical disorders of the small intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (4th edition, pp. 732–737). St. Louis, MO: Mosby.
Ed(s): B. Smith
Source: NC State University Libraries
Added: February 20, 2021
2009 journal article
Use of ultrasound to evaluate outcome following colic surgery for equine large colon volvulus
Equine Veterinary Journal, 42(1), 47–52.
Contributors: M. Sheats n, V. Cook n, S. Jones n , n & A. Pease n
author keywords: horse; colic; large colon volvulus; ultrasound; multiple organ dysfunction syndrome; oedema
MeSH headings : Animals; Colic / diagnostic imaging; Colic / surgery; Colic / veterinary; Colonic Diseases / diagnostic imaging; Colonic Diseases / surgery; Colonic Diseases / veterinary; Female; Horse Diseases / diagnostic imaging; Horse Diseases / surgery; Horses; Intestinal Volvulus / diagnostic imaging; Intestinal Volvulus / surgery; Intestinal Volvulus / veterinary; Male; Treatment Outcome; Ultrasonography
TL;DR:
A shorter time to colon wall involution was associated with decreased post operative morbidity in horses presented for surgical correction of large colon volvulus without resection and may aid in identifying those cases at risk of MODS.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Analysis of Sodium Carboxymethylcellulose Administration and Related Factors Associated with Postoperative Colic and Survival in Horses with Small Intestinal Disease
Veterinary Surgery, 37(6), 558–563.
MeSH headings : Animals; Carboxymethylcellulose Sodium / therapeutic use; Colic / prevention & control; Colic / surgery; Colic / veterinary; Female; Horse Diseases / mortality; Horse Diseases / surgery; Horses; Kaplan-Meier Estimate; Male; Postoperative Complications / drug therapy; Postoperative Complications / epidemiology; Postoperative Complications / mortality; Postoperative Complications / veterinary; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Tissue Adhesions / prevention & control; Tissue Adhesions / veterinary
TL;DR:
CBMC administration is seemingly protective against death and prolongs survival when used intraoperatively in horses with small intestine disease, particularly horses with postoperative colic or POI, both of which increased risk of death after surgery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Arginine Activates Intestinal p70S6k and Protein Synthesis in Piglet Rotavirus Enteritis
The Journal of Nutrition, 138(1), 24–29.
MeSH headings : Animals; Arginine / pharmacology; Dietary Supplements; Enteritis / blood; Enteritis / metabolism; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / virology; Jejunum / pathology; Protein Biosynthesis / drug effects; Ribosomal Protein S6 Kinases, 70-kDa / metabolism; Rotavirus Infections / enzymology; Rotavirus Infections / metabolism; Sirolimus / pharmacology; Swine / metabolism; Swine / virology
TL;DR:
It is concluded that, early in rotavirus enteritis, Arg has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation, while improving intestinal permeability via a mammalian target of rapamycin/p70( S6k)-independent mechanism.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2008 journal article
Arginine activates intestinal p70S6k and protein synthesis in piglet rotavirus enteritis
Journal of Nutrition, 138(1), 24–29. http://www.scopus.com/inward/record.url?eid=2-s2.0-38149032281&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2008 journal article
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine
Equine Veterinary Journal, 40(4), 353–357.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2008 journal article
Attenuation of ischaemic injury in the equine jejunum by administration of systemic lidocaine
Equine Veterinary Journal, 40(4), 353–357.
Contributors: V. Cook n, J. Jones Shults n, M. McDowell n, N. Campbell n, J. Davis n & n
author keywords: horse; colic; ischaemia; lidocaine; mucosal repair
MeSH headings : Anesthetics, Local / blood; Anesthetics, Local / therapeutic use; Animals; Clonixin / analogs & derivatives; Clonixin / pharmacology; Electric Impedance; Female; Horse Diseases / drug therapy; Horse Diseases / prevention & control; Horses; Infusions, Intravenous / veterinary; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Ischemia / drug therapy; Ischemia / prevention & control; Ischemia / veterinary; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Lidocaine / blood; Lidocaine / therapeutic use; Lipopolysaccharides / pharmacology; Male; Pain Measurement / veterinary; Permeability / drug effects; Reperfusion / veterinary; Time Factors; Tissue Culture Techniques / veterinary
TL;DR:
Treatment with systemic lidocaine ameliorated the inhibitory effects of flunixin meglumine on recovery of the mucosal barrier from ischaemic injury, when the 2 treatments were combined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: August 30, 2019
2008 journal article
ClC-2 is required for rapid restoration of epithelial tight junctions in ischemic-injured murine jejunum
Experimental Cell Research, 315(1), 110–118.
Contributors: P. Nighot n, A. Moeser n, K. Ryan n, T. Ghashghaei n & n
author keywords: Tight junction; Intestinal permeability; Ischemia; ClC-2
MeSH headings : Animals; CLC-2 Chloride Channels; Cell Membrane / metabolism; Chloride Channels / deficiency; Chloride Channels / metabolism; Epithelium / metabolism; Epithelium / pathology; Epithelium / ultrastructure; Fluorescent Antibody Technique; Immunoprecipitation; Ischemia / metabolism; Ischemia / physiopathology; Jejunum / blood supply; Jejunum / pathology; Jejunum / ultrastructure; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Protein Transport; Tight Junctions / metabolism; Tight Junctions / ultrastructure; Wound Healing
TL;DR:
A pivotal role is demonstrated in recovery of the intestinal epithelium barrier by anchoring assembly of tight junctions following ischemic injury in ClC-2(-/-) mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Comparison of the chloride channel activator lubiprostone and the oral laxative Polyethylene Glycol 3350 on mucosal barrier repair in ischemic-injured porcine intestine
World Journal of Gastroenterology, 14(39), 6012.
author keywords: Intestinal ischemia; Barrier function; Permeability; Laxative; Polyethylene Glycol
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Animals; Cell Membrane Permeability / drug effects; Cell Membrane Permeability / physiology; Chloride Channel Agonists; Disease Models, Animal; Epithelial Cells / drug effects; Epithelial Cells / physiology; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Inulin / metabolism; Laxatives / pharmacology; Lubiprostone; Male; Mannitol / metabolism; Polyethylene Glycols / pharmacology; Recovery of Function / drug effects; Reperfusion Injury / pathology; Reperfusion Injury / physiopathology; Swine
TL;DR:
Results suggest that, unlike osmotic laxatives, lubiprostone stimulates repair of the injured intestinal barrier, whereas the PEG laxative had deleterious effects on mucosal repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs
American Journal of Veterinary Research, 69(4), 457–464.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biopsy / veterinary; Blotting, Western / veterinary; Cross-Over Studies; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Dogs / metabolism; Endoscopy / veterinary; Female; Gastric Mucosa / drug effects; Gastric Mucosa / enzymology; Gastric Mucosa / metabolism; Histocytochemistry / veterinary; Intestinal Mucosa / drug effects; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Male; Prostaglandins / biosynthesis; Pyloric Antrum / drug effects; Pyloric Antrum / enzymology; Pyloric Antrum / metabolism; Random Allocation; Thromboxane B2 / metabolism
TL;DR:
In dogs, prostanoid synthesis was greater in pyloric mucosa than it was in duodenal mucosa, compared with the effects of a selective COX-2 NSAID.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Enrichment of Intestinal Mucosal Phospholipids with Arachidonic and Eicosapentaenoic Acids Fed to Suckling Piglets Is Dose and Time Dependent
The Journal of Nutrition, 138(11), 2164–2171.
Contributors: H. Hess n, B. Corl n, X. Lin n, S. Jacobi n, R. Harrell n, n , J. Odle n
MeSH headings : Animals; Arachidonic Acid / administration & dosage; Arachidonic Acid / pharmacology; Diet; Dose-Response Relationship, Drug; Drug Administration Schedule; Eicosapentaenoic Acid / administration & dosage; Eicosapentaenoic Acid / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Lactase / metabolism; Swine
TL;DR:
D doses demonstrate a dose-dependent response of intestinal mucosal phospholipid ARA concentration to dietary ARA with nearly full enrichment attained within 8 d of feeding formula containing ARA and that supra-physiologic supplementation of ARA is not detrimental to growth.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Equine colic | La colica degli equini
Ippologia, 19(3), 21–33. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349887661&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2008 journal article
Life in the Gut Without Oxygen: Adaptive Mechanisms and Inflammatory Bowel Disease
Gastroenterology, 134(1), 346–348.
MeSH headings : Adaptation, Physiological / physiology; Animals; Energy Metabolism / physiology; Humans; Hypoxia / complications; Hypoxia / metabolism; Hypoxia / physiopathology; Inflammatory Bowel Diseases / etiology; Inflammatory Bowel Diseases / metabolism; Inflammatory Bowel Diseases / physiopathology; Oxygen Consumption / physiology
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Managing pain associated with colic
Compendium on Continuing Education for the Practicing Veterinarian, 3, 294–307.
Source: NC State University Libraries
Added: October 18, 2020
2008 journal article
Mice lacking the Na+/H+ exchanger 2 have impaired recovery of intestinal barrier function
American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4), G791–G797.
Contributors: A. Moeser n, P. Nighot n, K. Ryan n, J. Simpson*, L. Clarke * & n
author keywords: tight junction; intestinal permeability; ischemia; Na(+)/H(+) exchange
MeSH headings : Animals; Claudin-1; Intestinal Mucosa / physiopathology; Intestine, Small / blood supply; Ischemia / physiopathology; Mannitol / metabolism; Membrane Proteins / metabolism; Mice; Mice, Knockout; Occludin; Permeability; Phosphorylation; Sodium-Hydrogen Exchangers / genetics; Sodium-Hydrogen Exchangers / physiology; Tight Junctions / metabolism; Tight Junctions / ultrastructure
TL;DR:
Recovery of barrier function was assessed in wild-type (NHE2(+/+)) and NHE2(-/-) mice in vivo and in vitro and pharmacological inhibition of N HE2 in postischemic tissues from wild- type mice also resulted in significant reductions in TER.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2008 journal article
Post operative ileus: To be or not to be?
Equine Veterinary Journal, 40(4), 295–296.
MeSH headings : Animals; Gastrointestinal Motility; Gastrointestinal Transit; Horse Diseases / epidemiology; Horse Diseases / etiology; Horse Diseases / prevention & control; Horses; Ileus / epidemiology; Ileus / etiology; Ileus / prevention & control; Ileus / veterinary; Intestinal Obstruction; Intestine, Small / pathology; Intestine, Small / surgery; Mortality; Postoperative Complications / epidemiology; Postoperative Complications / etiology; Postoperative Complications / prevention & control; Postoperative Complications / veterinary; Prevalence
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 chapter
Signs of colic
In M. Becker (Ed.), The ultimate horse lover : the best experts' advice for a happy, healthy horse with stories and photos of awe-inspiring equines (pp. 208–210). Deerfield Beach, FL: Health Communications.
Ed(s): M. Becker
Source: NC State University Libraries
Added: February 20, 2021
2008 journal article
T1298 Comparison of the Effects of a COX-2 Selective Inhibitor (Firocoxib) and a Traditional NSAID (Flunixin Meglumine) On Recovery of Ischemic-Injured Equine Jejunum
Gastroenterology, 134(4), A-525-A-526.
Sources: Crossref, NC State University Libraries
Added: September 8, 2020
2008 journal article
The effect of lidocaine on in vitro adhesion and migration of equine neutrophils
Veterinary Immunology and Immunopathology, 129(1-2), 137–142.
author keywords: Neutrophils; Equine; Immune functions; Local anesthetics
MeSH headings : Anesthetics, Local / pharmacology; Animals; Cell Adhesion / drug effects; Cell Adhesion / immunology; Cell Movement / drug effects; Cell Movement / immunology; Horses / blood; Horses / immunology; Interleukin-8 / immunology; Leukotriene B4 / immunology; Lidocaine / pharmacology; Neutrophil Activation / drug effects; Neutrophil Activation / immunology; Neutrophils / drug effects; Neutrophils / immunology; Platelet Activating Factor / immunology
TL;DR:
In conclusion, lidocaine did not inhibit neutrophil migration or adhesion in vitro at therapeutic concentrations, and increased migration and adhesion at higher concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
Use of systemically administered lidocaine in horses with gastrointestinal tract disease
Journal of the American Veterinary Medical Association, 232(8), 1144–1148.
Contributors: V. Cook n & *
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / veterinary; Horse Diseases / drug therapy; Horses; Ileus / drug therapy; Ileus / veterinary; Lidocaine / therapeutic use; Reperfusion Injury / drug therapy; Reperfusion Injury / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2008 journal article
W1268 Mechanism of Astrovirus Induced Diarrhea
Gastroenterology, 134(4), A-668.
Sources: Crossref, NC State University Libraries, ORCID
Added: December 19, 2018
2008 journal article
W1738 Gastroprotective Properties of Cobiprostone Against Acid and NSAID-Induced Mucosal Injury in Porcine Gastric Mucosa
Gastroenterology, 134(4), A-705.
Sources: Crossref, NC State University Libraries
Added: September 8, 2020
2007 journal article
Cyclooxygenase (COX) Inhibitors and the Intestine
Journal of Veterinary Internal Medicine, 21(3), 367–377.
TL;DR:
The major noncyclooxygenase targets of the COX inhibitors of particular relevance to inflammation and the gastrointestinal tract are phosphatidylinositol 3'-kinase Akt signaling, uncoupling of oxidative phosphorylation, PPARgamma, nuclear factor KB, mitogen activated protein kinases, and heat shock proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
Cyclooxygenase (COX) inhibitors and the intestine
Journal of Veterinary Internal Medicine, 21(3), 367–377.
Contributors: D. Little n, S. Jones & *
author keywords: heat shock protein; nonsteroidal anti-inflammatory drugs; nuclear factor kappa B; p38 mitogen activated protein kinases; peroxisome proliferator-activated receptor gamma
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: ORCID
Added: September 3, 2019
2007 article
Detection of differentially regulated genes in ischaemic equine intestinal mucosa
Tschetter, JR, Blikslager, A. T., Little, D., Howard, R. D., Woody, S. L., Beex, L. M., & Crisman, M. V. (2005, July). EQUINE VETERINARY JOURNAL, Vol. 37, pp. 319–324.
author keywords: horse; equine; ischaemia; gene expression
MeSH headings : Animals; Base Sequence; Blotting, Northern / veterinary; Cloning, Molecular; Colic / etiology; Colic / veterinary; Gene Expression Profiling; Gene Expression Regulation; Gene Library; Horse Diseases / genetics; Horses; Immunoblotting / veterinary; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Ischemia / genetics; Ischemia / veterinary; Jejunum / blood supply; Male; RNA / metabolism
TL;DR:
These initial results have identified a pool of equine intestinal epithelial genes that are differentially expressed following a 2 h ischaemic event, and genes indicative of deranged metabolic activity and those potentially involved in early repair events were identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Determination of minimum alveolar concentration of sevoflurane in juvenile swine
Research in Veterinary Science, 84(2), 283–285.
Contributors: A. Moeser n, n & C. Swanson n
MeSH headings : Anesthesia, Inhalation / veterinary; Anesthetics, Inhalation / pharmacokinetics; Animals; Methyl Ethers / pharmacokinetics; Pulmonary Alveoli; Sevoflurane; Swine / metabolism
TL;DR:
The sevoflurane MAC value was determined to be 3.5+/-0.1% which is notably higher than values reported in the literature for pigs, which may represent changes in anesthetic requirements between different age groups of pigs and differences in the type of stimulus used to determine MAC.
(via Semantic Scholar)
Sources: NC State University Libraries, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum
American Journal of Veterinary Research, 68(6), 614–624.
Contributors: D. Little n, S. Brown, N. Campbell*, A. Moeser*, J. Davis* & *
MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Intestinal Diseases / drug therapy; Intestinal Diseases / veterinary; Ischemia / veterinary; Jejunum / injuries; Meloxicam; Thiazines / pharmacokinetics; Thiazines / therapeutic use; Thiazoles / pharmacokinetics; Thiazoles / therapeutic use
TL;DR:
It is suggested that IV administration of meloxicam may be a useful alternative to flunixin meglumine for postoperative treatment of horses with colic.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Equine colic research: future prospects for an age-old problem
Journal of Equine Veterinary Science, 27(12), 546–547.
Source: NC State University Libraries
Added: October 18, 2020
2007 journal article
Expression of cyclooxygenase-1 and -2 in naturally occurring squamous cell carcinomas in horses
American Journal of Veterinary Research, 68(1), 76–80.
Contributors: Y. Elce n, J. Orsini n & n
MeSH headings : Animals; Blotting, Western / veterinary; Carcinoma, Squamous Cell / enzymology; Carcinoma, Squamous Cell / veterinary; Cyclooxygenase 1 / biosynthesis; Cyclooxygenase 2 / biosynthesis; Female; Horse Diseases / enzymology; Horses; Male; Neoplasms / enzymology; Neoplasms / veterinary
TL;DR:
Results indicated that the expression of COX proteins in both nonneoplastic and SCC-affected tissues in horses is markedly different from that in other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs
American Journal of Physiology-Gastrointestinal and Liver Physiology, 293(2), G413–G421.
author keywords: stress; barrier function; corticotropin releasing factor; tryptase
MeSH headings : Aging / metabolism; Animals; Cell Degranulation / drug effects; Colon, Ascending / drug effects; Colon, Ascending / metabolism; Corticotropin-Releasing Hormone / blood; Cromolyn Sodium / pharmacology; Cromolyn Sodium / therapeutic use; Electric Impedance; Gastrointestinal Agents / pharmacology; Gastrointestinal Agents / therapeutic use; Gastrointestinal Diseases / enzymology; Gastrointestinal Diseases / metabolism; Gastrointestinal Diseases / prevention & control; Gastrointestinal Diseases / psychology; Hydrocortisone / blood; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Secretions / metabolism; Jejunum / drug effects; Jejunum / metabolism; Mannitol / metabolism; Mast Cells / drug effects; Mast Cells / enzymology; Mast Cells / metabolism; Permeability; Receptors, Corticotropin-Releasing Hormone / metabolism; Stress, Psychological / complications; Stress, Psychological / enzymology; Stress, Psychological / metabolism; Swine; Time Factors; Tryptases / metabolism; Up-Regulation; Weaning
TL;DR:
The results indicate that early-weaning stress induces mucosal dysfunction mediated by intestinal mast cell activation and can be prevented by delaying weaning.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Mechanisms of porcine diarrheal disease
Journal of the American Veterinary Medical Association, 231(1), 56–67.
Contributors: A. Moeser n & n
MeSH headings : Animals; Diarrhea / microbiology; Diarrhea / physiopathology; Diarrhea / veterinary; Intestinal Absorption / physiology; Intestinal Mucosa / metabolism; Species Specificity; Swine; Swine Diseases / microbiology; Swine Diseases / physiopathology
TL;DR:
The objective of this report was to review the current understanding of the basic mechanisms of diarrheal diseases in swine, with particular emphasis on the ability of specific enteric pathogens to alter intestinal ion transport and fluid movement across intestinal epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Performance of the 808-nm diode laser on equine upper airway tissue is enhanced by intravenous administration of indocyanine green
PHOTOMEDICINE AND LASER SURGERY, 25(5), 443–448.
Contributors: L. Tate Jr., n & M. Papich n
MeSH headings : Animals; Coloring Agents / administration & dosage; Coloring Agents / pharmacology; Dose-Response Relationship, Drug; Horses; Indocyanine Green / administration & dosage; Indocyanine Green / pharmacology; Injections, Intravenous; Laser Therapy / instrumentation; Laser Therapy / methods; Lasers, Semiconductor; Nasal Mucosa / drug effects; Nasal Mucosa / radiation effects
TL;DR:
It is demonstrated that the 808-nm diode laser, when augmented with intravenous ICG, will be as effective a surgical tool as the Nd:YAG laser on equine upper airway tissues when applied using a non-contact fiber.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Pharmacokinetics of etodolac in the horse following oral and intravenous administration
Journal of Veterinary Pharmacology and Therapeutics, 30(1), 43–48.
Contributors: J. Davis n, M. Papich n , A. Morton *, J. Gayle*, * & N. Campbell n
MeSH headings : Administration, Oral; Animals; Area Under Curve; Cross-Over Studies; Cyclooxygenase 1 / drug effects; Cyclooxygenase 2 / drug effects; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / blood; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / pharmacology; Etodolac / administration & dosage; Etodolac / blood; Etodolac / pharmacokinetics; Etodolac / pharmacology; Female; Horses / metabolism; Injections, Intravenous / veterinary; Male
TL;DR:
It was showed that etodolac is well absorbed in the horse after oral administration, and may offer a useful alternative for anti-inflammatory treatment of various conditions in thehorse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 article
Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia
Little, D., Tomlinson, J. E., & Blikslager, A. T. (2005, July). EQUINE VETERINARY JOURNAL, Vol. 37, pp. 329–335.
MeSH headings : Analysis of Variance; Animals; Horse Diseases / immunology; Horses; Ileus / immunology; Ileus / veterinary; Immunohistochemistry / veterinary; Ischemia / immunology; Ischemia / veterinary; Jejunum / blood supply; Jejunum / pathology; Leukocyte L1 Antigen Complex / metabolism; Neutrophil Infiltration; Neutrophils / metabolism; Neutrophils / physiology; Postoperative Complications / immunology; Postoperative Complications / veterinary; Postoperative Period; Random Allocation
TL;DR:
This neutrophilic inflammation coincides with the clinical time point at which POI is identified and may indicate that inflammatory pathways, rather than solely neurogenic pathways, are responsible for POI in the horse.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Preputial melanoma with systemic metastasis in a pony gelding and disseminated metastatic melanoma in a Thoroughbred gelding
EQUINE VETERINARY EDUCATION, 19(6), 312–315.
Contributors: E. Garvican n, Y. Elce n, K. Woolard n & n
author keywords: horse; melanoma; metastasis; tumour; penis
TL;DR:
The presenting signs, diagnostic findings and necropsy results of 2 horses subsequently diagnosed with systemic metastatic melanoma are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Restoration of Barrier Function in Injured Intestinal Mucosa
Physiological Reviews, 87(2), 545–564.
MeSH headings : Animals; Epithelial Cells / physiology; Humans; Inflammation / pathology; Intestinal Diseases / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Mucous Membrane / cytology; Mucous Membrane / physiology
TL;DR:
Ex vivo studies of mammalian small intestine have revealed the importance of closure of the interepithelial tight junctions and the paracellular space, which underscores the critical role of tight junction closure in measures of barrier function such as transepithelial electrical resistance.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Spontaneous rupture of the guttural pouch as a complication of treatment for guttural pouch empyema
EQUINE VETERINARY EDUCATION, 19(7), 351–355.
Contributors: C. Fogle n , M. Gerard n, A. Johansson n, B. Breuhaus n , n & S. Jones n
author keywords: horse; guttural pouch; empyema; rupture; complication
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Cyclooxygenase expression in the early stages of equine laminitis: A cytologic study
Journal of Veterinary Internal Medicine, 20(5), 1191–1196.
TL;DR:
COX-2 protein expression is markedly increased in the resident laminar cell types in the developmental stage of BWE-induced laminitis, although a lesser increase was observed in the LAM group.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2006 journal article
Cyclooxygenase expression in the early stages of equine laminitis: A cytologic study
Journal of Veterinary Internal Medicine, 20(5), 1191–1196.
Contributors: n , C. Yin*, A. Cochran*, J. Wooten n, A. Pettigrew* & J. Belknap *
author keywords: cyclooxygenase-1 (COX-1); cyclooxygenase-2 (COX-2); immunoblot; immunohistochemistry; laminae; real-time quantitative polymerase chain reaction (RT-qPCR)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: September 3, 2019
2006 journal article
Intestinal mucosal epithelium: The barrier to sepsis
Journal of Organ Dysfunction, 2(4), 250–253.
TL;DR:
Barrier function and prevention of sepsis are related to the ability of the epithelium to react in an appropriate manner to luminal bacteria, prevent passage of bacteria across the barrier, and rapidly repair the barrier when it is damaged.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: ORCID
Added: September 3, 2019
2006 journal article
Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis
American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(3), G913–G922.
Contributors: J. Rhoads *, B. Corl n, R. Harrell n, X. Niu*, L. Gatlin n, O. Phillips n, n , A. Moeser n, G. Wu *, J. Odle n
author keywords: mammalian target of rapamycin; diarrhea; virus; malnutrition
MeSH headings : Amino Acids / blood; Animals; Animals, Newborn; Antigens, Viral / analysis; Body Weight; Diarrhea / metabolism; Diarrhea / pathology; Energy Intake; Enteritis / blood; Enteritis / metabolism; Enteritis / virology; Enterocytes / chemistry; Enterocytes / metabolism; Feces / chemistry; Intestinal Mucosa / chemistry; Intestinal Mucosa / metabolism; Jejunum / chemistry; Jejunum / metabolism; Lactase / metabolism; Malnutrition / metabolism; Malnutrition / physiopathology; Muscle, Skeletal / metabolism; Muscle, Smooth / metabolism; Phosphorylation; Protein Kinases / physiology; Ribosomal Protein S6 Kinases, 70-kDa / analysis; Ribosomal Protein S6 Kinases, 70-kDa / metabolism; Rotavirus Infections / blood; Rotavirus Infections / metabolism; Signal Transduction / physiology; Sus scrofa; TOR Serine-Threonine Kinases
TL;DR:
In conclusion, intestinal activation of p70(S6K) was not inhibited by malnutrition but was strongly activated during an active state of mucosal regeneration, mainly in the crypt.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Letters to the Editor
Journal of the American Veterinary Medical Association, 228(7), 1011–1012.
MeSH headings : Animals; Colon; Colonic Diseases / diagnostic imaging; Colonic Diseases / veterinary; Diagnosis, Differential; Horse Diseases / diagnostic imaging; Horses; Intestinal Volvulus / diagnostic imaging; Intestinal Volvulus / veterinary; Ultrasonography
Sources: Crossref, NC State University Libraries
Added: October 6, 2019
2006 journal article
Mucosal permeability of water-soluble drugs in the equine jejunum: a preliminary investigation
Journal of Veterinary Pharmacology and Therapeutics, 29(5), 379–385.
MeSH headings : Animals; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Biological Availability; Cephalexin / chemistry; Cephalexin / pharmacokinetics; Fluconazole / chemistry; Fluconazole / pharmacokinetics; Fluoroquinolones / chemistry; Fluoroquinolones / pharmacokinetics; Horses; Intestinal Mucosa / drug effects; Jejunum / metabolism; Linear Models; Metronidazole / chemistry; Metronidazole / pharmacokinetics; Permeability / drug effects; Quinolones / chemistry; Quinolones / pharmacokinetics; Solubility
TL;DR:
The Ussing chamber is a promising method for determining mucosal permeability in the horse and the low permeability of cephalexin across the tissue may indicate a lack of active transporters that are found in other species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
North Carolina State University's College of Veterinary Medicine announces plans to expand equine services
JOURNAL OF EQUINE VETERINARY SCIENCE, 26(4), 148-+.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Predisposing factors for small colon impaction in horses and outcome of medical and surgical treatment: 44 cases (1999–2004)
Journal of the American Veterinary Medical Association, 229(10), 1612–1616.
Contributors: L. Frederico n, S. Jones* & *
MeSH headings : Abdomen / pathology; Animals; Cathartics / therapeutic use; Diarrhea / complications; Diarrhea / veterinary; Fecal Impaction / drug therapy; Fecal Impaction / surgery; Fecal Impaction / veterinary; Female; Horse Diseases / drug therapy; Horse Diseases / surgery; Horses; Male; Prognosis; Retrospective Studies; Risk Factors; Treatment Outcome
TL;DR:
It is suggested that diarrhea may be a risk factor for development of small Colon impaction and that horses with small colon impaction that have abdominal distension at the time of initial examination are more likely to require surgical than medical treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 book
Principles of Intestinal Injury and Determination of Intestinal Viability
In Equine Surgery (pp. 395–401).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: September 3, 2019
2006 journal article
Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine
American Journal of Physiology-Gastrointestinal and Liver Physiology, 291(5), G885–G894.
author keywords: tight junction; restitution; Na+/H+ exchange
MeSH headings : Animals; Blotting, Western; Diffusion Chambers, Culture; Electric Impedance; Electrophoresis, Polyacrylamide Gel; Female; Guanidines / pharmacology; Ileum / blood supply; Ileum / metabolism; Immunohistochemistry; Immunoprecipitation; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Intestinal Mucosa / blood supply; Intestinal Mucosa / metabolism; Intestines / blood supply; Intestines / pathology; Ischemia / pathology; Male; Methacrylates / pharmacology; Prostaglandins / pharmacology; Regional Blood Flow / drug effects; Regional Blood Flow / physiology; Sodium / metabolism; Sodium-Hydrogen Exchangers / antagonists & inhibitors; Sulfones / pharmacology; Swine
TL;DR:
Selective inhibition of NHE2, and not NHE3, induces recovery of barrier function in the ischemia-injured intestine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone
American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(2), G647–G656.
author keywords: ischemia; type 2 chloride channels; repair
MeSH headings : Alprostadil / analogs & derivatives; Alprostadil / pharmacology; Alprostadil / therapeutic use; Animals; Bumetanide / pharmacology; CLC-2 Chloride Channels; Chloride Channel Agonists; Chloride Channels / antagonists & inhibitors; Chlorides / pharmacology; Colon / blood supply; Colon / drug effects; Colon / physiopathology; Cystic Fibrosis Transmembrane Conductance Regulator / antagonists & inhibitors; Dinoprostone / pharmacology; Electric Impedance; Electrophysiology; Fatty Acids / pharmacology; Fatty Acids / therapeutic use; Female; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Lubiprostone; Male; Mannitol / metabolism; Membrane Proteins / metabolism; Occludin; Permeability; Recovery of Function / drug effects; Sus scrofa; Urea / analogs & derivatives; Urea / pharmacology; Zinc Compounds / pharmacology
TL;DR:
Prostones such as lubiprostone may provide a selective and novel pharmacological mechanism of accelerating recovery of acutely injured intestine compared with the nonselective action of prostaglandins such as PGE(2).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Red maple (Acer rubrum) leaf toxicosis in horses: A retrospective study of 32 cases
JOURNAL OF VETERINARY INTERNAL MEDICINE, 20(5), 1197–1201.
author keywords: equidae; Heinz body; hemolysis; methemoglobin
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 book
Source: ORCID
Added: September 3, 2019
2006 journal article
Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig
American Journal of Physiology-Gastrointestinal and Liver Physiology, 292(1), G173–G181.
author keywords: barrier function; secretion
MeSH headings : Animals; Colon / physiopathology; Disease Models, Animal; Female; Jejunum / physiopathology; Male; Maternal Behavior; Muscle, Smooth / physiopathology; Signal Transduction; Stress, Psychological / physiopathology; Swine; Weaning
TL;DR:
The results indicate that weaning stress induces mucosal dysfunction mediated by intestinal CRF receptors and activated by enteric nerves and prostanoid pathways.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Views conclusions in ultrasound study as unsupported [1]
Journal of the American Veterinary Medical Association, 228(7). http://www.scopus.com/inward/record.url?eid=2-s2.0-33645467501&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2005 conference paper
A guide for calculation of spot size to determine power density for free fiber irradiation of tissue
Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5686, 606–611.
author keywords: laser surgery; equine surgery; upper respiratory tract diode laser; Nd : YAG laser; power density; energy density; spot size; veterinary medicine
TL;DR:
The charts derived from this study provide the veterinarian the ability to estimate spot size for a number of commonly used lasers with the fiber positioned at various distances from the target.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: September 3, 2019
2005 journal article
Association of Veterinary Teachers and Research Workers (Irish region) 41th Winter Scientific meeting
Irish Veterinary Journal, 58(3), 171–176. http://www.scopus.com/inward/record.url?eid=2-s2.0-20144369853&partnerID=MN8TOARS
Contributors: M. Glyde, D. Fitzpatrick, R. Shahar, T. McCreary, B. Mac Giolla Ri, A. Staines, J. Rodgers, N. Connery
Source: ORCID
Added: September 3, 2019
2005 journal article
Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine
Histochemistry and Cell Biology, 125(3), 293–305.
Contributors: P. Schierack *, M. Nordhoff*, M. Pollmann*, K. Weyrauch*, S. Amasheh *, U. Lodemann *, J. Jores *, B. Tachu*
author keywords: microbial pathogenesis; in vitro infection model; porcine intestinal epithelial cell line
MeSH headings : Animals; Bacteria / pathogenicity; Bacterial Infections / etiology; Bacterial Infections / microbiology; Bacterial Infections / veterinary; Base Sequence; Cell Line; Cytokines / genetics; DNA Primers / genetics; Epithelial Cells / microbiology; Escherichia coli Infections / etiology; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; In Vitro Techniques; Intestines / cytology; Intestines / microbiology; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Reverse Transcriptase Polymerase Chain Reaction; Salmonella Infections, Animal / etiology; Salmonella Infections, Animal / microbiology; Swine / microbiology; Swine Diseases / etiology; Swine Diseases / microbiology
TL;DR:
The permanent porcine intestinal epithelial cell line, IPEC-J2, is characterized using a variety of methods to assess the usefulness of this cell line as an in vitro infection model and concludes that it provides a relevant in vitro model system for porCine intestinal pathogen–host cell interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018
2005 journal article
Detection of differentially regulated genes in ischaemic equine intestinal mucosa
Equine Veterinary Journal, 37(4), 319–324. http://www.scopus.com/inward/record.url?eid=2-s2.0-22144488823&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2005 journal article
Effects of cyclooxygenase inhibitors flunixin and deracoxib on permeability of ischaemic-injured equine jejunum
EQUINE VETERINARY JOURNAL, 37(1), 75–80.
Contributors: J. Tomlinson n & n
author keywords: horse; intestine; nonsteroidal anti-inflammatory; flunixin; deracoxib
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Biological Transport; Clonixin / analogs & derivatives; Clonixin / pharmacology; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Electric Impedance; Histological Techniques; Horse Diseases / drug therapy; Horses; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Ischemia / drug therapy; Ischemia / veterinary; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Mannitol / metabolism; Misoprostol / pharmacology; Permeability / drug effects; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / metabolism; Reperfusion / veterinary; Sulfonamides / pharmacology; Tritium
TL;DR:
Treatment of horses with ischaemic jejunal disease with flunixin may result in a prolonged permeability defect in recovering mucosa, which may have implications for the use of nonsteroidal anti-inflammatory drugs in colic patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 article
Equine reproductive services at North Carolina State University
Blikslager, A. (2005, December). JOURNAL OF EQUINE VETERINARY SCIENCE, Vol. 25, pp. 501–501.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Faecal bile loss in horses following small intestinal resection
EQUINE VETERINARY JOURNAL, 37(1), 92–94.
author keywords: horse; small intestine; resection; bile; faeces
MeSH headings : Analysis of Variance; Animals; Bile Acids and Salts / analysis; Colic / metabolism; Colic / surgery; Colic / veterinary; Feces / chemistry; Horse Diseases / metabolism; Horse Diseases / surgery; Horses; Intestine, Small / surgery
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2005 journal article
Gastrointestinal tract perforation in dogs treated with a selective cyclooxygenase-2 inhibitor: 29 cases (2002-2003)
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 227(7), 1112–1117.
Contributors: B. Lascelles n, n , S. Fox n & D. Reece n
MeSH headings : Acute Disease; Adrenal Cortex Hormones / therapeutic use; Adverse Drug Reaction Reporting Systems; Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Chronic Disease; Cyclooxygenase Inhibitors / adverse effects; Cyclooxygenase Inhibitors / therapeutic use; Dog Diseases / chemically induced; Dog Diseases / mortality; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Intestinal Perforation / chemically induced; Intestinal Perforation / mortality; Intestinal Perforation / veterinary; Pain / drug therapy; Pain / veterinary; Retrospective Studies; Sulfonamides / adverse effects; Sulfonamides / therapeutic use; Survival Rate
TL;DR:
In dogs with gastrointestinal tract perforation and that had been treated with deracoxib, perforations was most likely attributable to a number of factors, and derac oxib should only be used at approved dosages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Post operative neutrophilic inflammation in equine small intestine after manipulation and ischaemia
Equine Veterinary Journal, 37(4), 329–335. http://www.scopus.com/inward/record.url?eid=2-s2.0-22144461056&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2004 journal article
Arginine stimulates intestinal cell migration through a focal adhesion kinase dependent mechanism
Gut, 53(4), 514–522.
Contributors: J. Rhoads *, W. Chen*, J. Gookin n , G. Wu*, Q. Fu *, n , R. Rippe*, R. Argenzio n
MeSH headings : Animals; Arginine / pharmacology; Cell Movement / drug effects; Cells, Cultured; Dietary Supplements; Dose-Response Relationship, Drug; Enterocytes / drug effects; Enterocytes / physiology; Enzyme Inhibitors / pharmacology; Focal Adhesion Protein-Tyrosine Kinases; Nitric Oxide / metabolism; Ornithine Decarboxylase / physiology; Ornithine Decarboxylase Inhibitors; Phosphorylation / drug effects; Polyamines / pharmacology; Protein-Tyrosine Kinases / physiology; Swine; Transfection; Tyrosine / physiology
TL;DR:
Results showed that l-arginine stimulates cell migration through NO and FAK dependent pathways and that combination therapy with arginine and BSC may enhance intestinal restitution via separate and convergent pathways.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2004 journal article
CIC-2 chloride secretion mediates prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum
GASTROENTEROLOGY, 127(3), 802–815.
Contributors: A. Moeser n, M. Haskell n, D. Shifflett n, D. Little n, B. Schultz* & n
MeSH headings : Animals; CLC-2 Chloride Channels; Chloride Channels / metabolism; Chlorides / metabolism; Dinoprostone / pharmacology; Electric Impedance; Female; Ileum / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / physiopathology; Ischemia / metabolism; Ischemia / physiopathology; Male; Models, Animal; Permeability / drug effects; Prostaglandins / pharmacology; Recovery of Function / drug effects; Recovery of Function / physiology; Swine
TL;DR:
ClC-2-mediated intestinal Cl - secretion restores TER in ischemia-injured intestine and may provide the basis for targeted pharmacologic therapy for diseases associated with impaired barrier function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 book
Disorders of the Gastrointestinal System
In Equine Internal Medicine: Second Edition (pp. 1–181).
Source: ORCID
Added: September 3, 2019
2004 article
Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy
JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 18, pp. 555–563.
author keywords: behavior; colic; cortisol; pain management; stress
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Effects of continuous rate intravenous infusion of butorphanol on physiologic and outcome variables in horses after celiotomy
Journal of Veterinary Internal Medicine, 18(4), 555–563.
Source: ORCID
Added: September 3, 2019
2004 journal article
Effects of flunixin meglumine or etodolac treatment on mucosal recovery of equine jejunum after ischemia
AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(6), 761–769.
Contributors: J. Tomlinson n, O. Wilder n, K. Young n & n
MeSH headings : Animals; Biological Transport; Blotting, Western; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Clonixin / therapeutic use; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacokinetics; Cyclooxygenase Inhibitors / therapeutic use; Eicosanoids / metabolism; Electric Impedance; Epithelium / blood supply; Etodolac / pharmacokinetics; Etodolac / therapeutic use; Gene Expression; Histological Techniques; Horse Diseases / drug therapy; Horses; Ischemia / drug therapy; Ischemia / veterinary; Isoenzymes / metabolism; Jejunum / blood supply; Mannitol; Neutrophils; Pain Measurement / veterinary; Prostaglandin-Endoperoxide Synthases / metabolism; Reperfusion / veterinary; Time Factors; Tritium
TL;DR:
Flunixin and etodolac treatment retarded recovery of intestinal barrier function in jejunal mucosa after 18 hours of reperfusion, whereas tissues from horses treated with saline solution recovered baseline values of TER and permeability to mannitol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Effects of ischemia and the cyclooxygenase inhibitor flunixin on in vitro passage of lipopolysaccharide across equine jejunum
AMERICAN JOURNAL OF VETERINARY RESEARCH, 65(10), 1377–1383.
Contributors: J. Tomlinson n & *
MeSH headings : Acute-Phase Proteins / metabolism; Analysis of Variance; Animals; Biological Transport / drug effects; Blotting, Western / veterinary; Carrier Proteins / metabolism; Clonixin / analogs & derivatives; Clonixin / pharmacology; Electrophoresis, Polyacrylamide Gel / veterinary; Fluorescence; Horse Diseases / metabolism; Horses; In Vitro Techniques; Ischemia / metabolism; Ischemia / veterinary; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Lipopolysaccharides / metabolism; Membrane Glycoproteins / metabolism; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Evaluated the clinical importance of flunixin-associated delayed mucosal recovery requires further in vivo investigation, and ischemia increased LPS passage across equine jejunal mucosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Interactions between lipopolysaccharide and the intestinal epithelium
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 224(9), 1446–1452.
Contributors: J. Tomlinson n & *
MeSH headings : Animals; Chemotaxis; Endotoxemia / microbiology; Endotoxemia / physiopathology; Endotoxemia / veterinary; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestinal Mucosa / microbiology; Lipopolysaccharides / chemistry; Lipopolysaccharides / metabolism
TL;DR:
Endotoxemia is a result of absorption of lipopolysaccharide from intestinal gram-negative bacteria, and small amounts of LPS may be found in the portal blood of healthy individuals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Mitogen-activated protein kinases regulate COX-2 and mucosal recovery in ischemic-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 286(6), G906–G913.
author keywords: intestine; prostaglandin; transepithelial electrical resistance; cyclooxygenase 2
MeSH headings : Animals; Cyclooxygenase 2; Electric Impedance; Enzyme Activation; Enzyme Inhibitors / pharmacology; Female; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinase 1 / antagonists & inhibitors; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Prostaglandin-Endoperoxide Synthases / metabolism; Recovery of Function; Swine; p38 Mitogen-Activated Protein Kinases
TL;DR:
COX-2 expression appears to be positively and negatively regulated by the p38 MAPK and the JNK pathways, respectively, and ERK1/2 appear to be involved in COX- 2-independent reparative events that remain to be defined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Neutrophils augment recovery of porcine ischemia-injured ileal mucosa by an IL-1β- and COX-2-dependent mechanism
American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(1), G50–G57.
Contributors: D. Shifflett n, F. Bottone Jr., K. Young*, A. Moeser*, S. Jones* & *
author keywords: intestine; prostaglandin; transepithelial electrical resistance; tight junction
MeSH headings : Animals; Cyclooxygenase 2; Dose-Response Relationship, Drug; Electric Impedance; Female; Ileum / blood supply; Ileum / physiopathology; Interleukin-1 / administration & dosage; Interleukin-1 / metabolism; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Isoenzymes / metabolism; Male; Neutrophils; Prostaglandin-Endoperoxide Synthases / metabolism; Swine
TL;DR:
PMNs augment recovery of TER in ischemia-injured ileal mucosa via IL-1beta-dependent upregulation of COX-2, and this action was inhibited by pretreatment with the nonselective cyclooxygenase (COX) inhibitor indomethacin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2004 chapter
Pathophysiology of the Gastrointestinal Tract
In R. H. Dunlop & C. H. Malbert (Eds.), Veterinary Pathophysiology (1st edition, pp. 111–142). Ames, Iowa: Iowa State Press.
Ed(s): R. Dunlop & C. Malbert
Source: NC State University Libraries
Added: October 18, 2020
2004 journal article
Physiological concentrations of bile salts inhibit recovery of ischemic-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 287(2), G399–G407.
Contributors: N. Campbell n, C. Ruaux, D. Shifflett*, J. Steiner, D. Williams & *
author keywords: mucosa; barrier function; deoxycholic acid; tight junction
MeSH headings : Animals; Bile Acids and Salts / analysis; Calcium / metabolism; Deoxycholic Acid / pharmacology; Female; Ileum / blood supply; Ileum / chemistry; Ileum / pathology; Ileum / physiopathology; Ischemia / metabolism; Ischemia / pathology; Ischemia / physiopathology; Male; Microscopy, Electron; Osmolar Concentration; Permeability / drug effects; Recovery of Function / drug effects; Swine; Taurodeoxycholic Acid / pharmacology
TL;DR:
Deoxycholic acid at physiological concentrations significantly impairs recovery of epithelial barrier function by an effect on paracellular pathways, and these effects appear to be Ca(2+) dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Preferential and non-selective cyclooxygenase inhibitors reduce inflammation during lipopolysaccharide-induced synovitis
Research in Veterinary Science, 78(2), 189–192.
Contributors: A. Morton n, N. Campbell n, J. Gayle n, W. Redding n & n
author keywords: prostaglandin; synovitis; etodolac; phenylbutazone; thromboxane
MeSH headings : Animals; Anti-Inflammatory Agents / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / analysis; Enzyme-Linked Immunosorbent Assay / veterinary; Etodolac / pharmacology; Horse Diseases / drug therapy; Horse Diseases / enzymology; Horse Diseases / pathology; Horses; Leukocyte Count / veterinary; Lipopolysaccharides; Phenylbutazone / pharmacology; Random Allocation; Synovial Fluid / chemistry; Synovitis / drug therapy; Synovitis / enzymology; Synovitis / pathology; Synovitis / veterinary; T-Box Domain Proteins / analysis
TL;DR:
Etodolac may serve as a more selective anti-inflammatory agent than phenylbutazone for treatment of equine synovitis, as compared to non-selective COX inhibitors.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
A Retrospective Analysis of Hepatic Injury in Horses with Proximal Enteritis (1984-2002)
Journal of Veterinary Internal Medicine, 17(6), 896–901.
MeSH headings : Acid-Base Equilibrium / physiology; Alanine Transaminase / blood; Animals; Aspartate Aminotransferases / blood; Blood Cell Count / veterinary; Enteritis / complications; Enteritis / enzymology; Enteritis / veterinary; Heart Rate / physiology; Horse Diseases / enzymology; Horse Diseases / etiology; Horses; Intestinal Obstruction / veterinary; Liver Diseases / enzymology; Liver Diseases / etiology; Liver Diseases / veterinary; Logistic Models; Retrospective Studies; gamma-Glutamyltransferase / blood
TL;DR:
The conclusion is that horses with PE are more likely to have hepatic injury than horses with SISO.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: July 28, 2019
2003 journal article
A Retrospective Analysis of Hepatic Injury in Horses with Proximal Enteritis (1984-2002)
Journal of Veterinary Internal Medicine, 17(6), 896–901.
Source: ORCID
Added: September 3, 2019
2003 journal article
A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002)
JOURNAL OF VETERINARY INTERNAL MEDICINE, 17(6), 896–901.
author keywords: colic; duodenitis-proximal jejunitis; equine; gastric reflux; hepatopathy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
Cyclooxygenase blockade and exogenous glutamine enhance sodium absorption in infected bovine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(3), G516–G524.
Contributors: J. Cole*, * , E. Hunt n, J. Gookin* & R. Argenzio*
author keywords: Cryptosporidium parvum; Na/H exchanger 3; cyclooxygenase-2; diarrhea
MeSH headings : Animals; Biological Transport, Active; Blotting, Western; Cattle; Chlorine; Cryptosporidiosis / metabolism; Cryptosporidiosis / parasitology; Cryptosporidium parvum; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Glutamine / pharmacology; Ileum / metabolism; Ileum / parasitology; Ileum / pathology; Inflammation / pathology; Intestinal Absorption / drug effects; Intestinal Absorption / physiology; Isoenzymes / metabolism; Male; Prostaglandin-Endoperoxide Synthases / metabolism; Radioisotopes; Sodium / metabolism; Sodium Radioisotopes; Tissue Fixation
TL;DR:
It is shown that prostanoids inhibit electroneneutral sodium absorption in Cryptosporidium parvum-infected porcine ileum, whereas glutamine stimulates electroneutral sodium absorption via a cyclooxygenase (COX)-dependent pathway, and glutamine increases sodium uptake by an electrogenic mechanism in this same tissue.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2003 chapter
Esophageal diseases
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (2nd edition, pp. 913–921). St. Louis, MO: Saunders Elsevier.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: October 18, 2020
2003 chapter
Ischemic disorders of the intestinal tract
In S. M. Reed, W. M. Bayly, & D. C. Sellon (Eds.), Equine Internal Medicine (2nd edition, pp. 802–814). St. Louis, MO: Saunders Elsevier.
Ed(s): S. Reed, W. Bayly & D. Sellon
Source: NC State University Libraries
Added: October 18, 2020
2003 journal article
PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 285(5), G967–G979.
Contributors: J. Gookin n , J. Galanko *, n & R. Argenzio n
author keywords: resistance; permeability; tight junction; deoxycholate
MeSH headings : Animals; Deoxycholic Acid / pharmacology; Detergents / pharmacology; Gastrointestinal Motility; Ileum / drug effects; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Microscopy, Electron; Microvilli; Permeability / drug effects; Prostaglandins / metabolism; Recovery of Function; Swine; Wound Healing
TL;DR:
These studies are the first to clearly distinguish the relative contribution of paracellular resistance vs. restitution to acute recovery of epithelial barrier function and underlie barrier failure resulting from NSAID use in patients with underlying enteropathy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2003 journal article
PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G46–G56.
author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
TL;DR:
These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2003 book
Rectal Tears: Initial Management and Liability
In Current Therapy in Equine Medicine: Fifth Edition (pp. 150–153).
Source: ORCID
Added: September 3, 2019
2003 journal article
Role of nonsteroidal anti-inflammatory drugs in gastrointestinal tract injury and repair
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 222(7), 946–951.
Contributors: J. Tomlinson n & n
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cyclooxygenase Inhibitors / adverse effects; Cyclooxygenase Inhibitors / therapeutic use; Digestive System / drug effects; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / veterinary; Prostaglandins / biosynthesis; Wound Healing / drug effects
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 book
Strangulating Obstruction of the Small Intestine
In Current Therapy in Equine Medicine: Fifth Edition (pp. 124–126).
Source: ORCID
Added: September 3, 2019
2003 journal article
Treatment of gastrointestinal ischemic injury
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 19(3), 715-+.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Gastrointestinal Tract / blood supply; Horse Diseases / prevention & control; Horse Diseases / therapy; Horses; Ischemia / therapy; Ischemia / veterinary; Reperfusion Injury / prevention & control; Reperfusion Injury / veterinary
TL;DR:
Recent studies evaluating NSAIDs have revealed the potential of flunixin meglumine to retard the mucosal repair process, indicating the need for judicious use of this drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 conference paper
Determination of non-contact penetration parameters of the 60 watt 810 nm diode laser on equine respiratory tissue
Proceedings of SPIE - The International Society for Optical Engineering, 4609, 254–259.
author keywords: Nd : YAG laser; transendoscopic technique; 810nm diode laser; equine respiratory lesion; veterinary medicine
TL;DR:
Evidence is provided that the 60 watt 810nm diode laser produces substantial penetration that can be applied not only in the contact mode successfully, but also in the non-contact mode providing the practitioner with a more versatile laser for transendoscopic application in the equine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: ORCID
Added: September 3, 2019
2002 journal article
Endoscopy via a gastric cannula to monitor the development of ulcers in the pars esophagea in pigs after consumption of a finely ground feed combined with a period of withholding of feed
AMERICAN JOURNAL OF VETERINARY RESEARCH, 63(8), 1076–1082.
Contributors: J. Cole n, J. Gookin n , J. Gayle n, J. Eisemann n, R. Argenzio n & n
MeSH headings : Animal Feed / adverse effects; Animals; Catheterization / veterinary; Endoscopy, Digestive System / instrumentation; Endoscopy, Digestive System / veterinary; Food Deprivation / physiology; Male; Particle Size; Stomach Ulcer / etiology; Stomach Ulcer / metabolism; Stomach Ulcer / pathology; Stomach Ulcer / veterinary; Swine; Swine Diseases / etiology; Swine Diseases / metabolism; Swine Diseases / pathology
TL;DR:
Endoscopic examination via a gastric cannula was an effective means of monitoring ulcer development in the pars esophagea of pigs and direct visual examination during necropsy confirmed the accuracy of endoscopic examination.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2002 conference paper
Evaluation of topical application of indocyanine green (ICG) to enhance penetration of the 810nm diode laser on equine respiratory tissue
Proceedings of SPIE - The International Society for Optical Engineering, 4609, 247–253.
author keywords: Nd : YAG laser; 810nm diode laser; equine respiratory tissue; Indocyanine Green (ICG); transendoscopic; veterinary medicine
TL;DR:
This study indicated that intravenous administration of indocyanine green (ICG) greatly enhanced the depth and width of crater formation in equine respiratory tissue with the laser set at 200 joules total power output, and concluded that topical administration of ICG was more economical than intravenously administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 3, 2019
2002 journal article
Factors associated with development of ileal impaction in horses with surgical colic: 78 Cases (1986-2000)
Equine Veterinary Journal, 34(5), 464–468. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036637533&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2002 article
Factors associated with development of ileal impaction in horses with surgical colic: 78 cases (1986-2000)
Little, D., & Blikslager, A. T. (2002, July). EQUINE VETERINARY JOURNAL, Vol. 34, pp. 464–468.
author keywords: horse; colic; ileal impaction, hay, pyrantel salt
MeSH headings : Animal Feed; Animals; Antinematodal Agents / administration & dosage; Cestode Infections / complications; Cestode Infections / prevention & control; Cestode Infections / veterinary; Colic / surgery; Colic / veterinary; Cynodon / adverse effects; Female; Horse Diseases / etiology; Horse Diseases / surgery; Horses; Ileal Diseases / etiology; Ileal Diseases / surgery; Ileal Diseases / veterinary; Intestinal Obstruction / etiology; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Logistic Models; Male; Odds Ratio; Pyrantel / administration & dosage; Retrospective Studies; Risk Factors; United States
TL;DR:
It is confirmed that feeding Coastal Bermuda hay places horses at risk of ileal impaction, although the quality of the hay may also play a role, and periodic administration of anthelmintics with efficacy against tapeworms should be considered to reduce risk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum
SURGERY, 132(3), 461–470.
MeSH headings : Animals; Antibodies, Monoclonal / immunology; CD11 Antigens / physiology; CD18 Antigens / physiology; Electric Impedance; Ileum / blood supply; Ileum / metabolism; Ileum / pathology; Ischemia / metabolism; Ischemia / pathology; Neutrophils / physiology; Permeability; Polyethylene Glycols / pharmacology; Superoxide Dismutase / pharmacology; Swine
TL;DR:
Pretreatment with anti-CD11/CD18 monoclonal antibody and superoxide dismutase-polyethylene glycol significantly reduced neutrophil infiltration and normalized transepithelial electrical resistance and mannitol fluxes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2002 journal article
Neutrophils increase paracellular permeability of restituted ischemic-injured porcine ileum
Surgery, 132(3), 461–470.
Source: ORCID
Added: September 3, 2019
2002 journal article
Recovery of ischaemic injured porcine ileum: evidence for a contributory role of COX-1 and COX-2
Gut, 50(5), 615–623.
Contributors: n , D. Zimmel, K. Young, N. Campbell, D. Little & R. Argenzio
MeSH headings : Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Eicosanoids / biosynthesis; Female; Ileum / blood supply; Ileum / drug effects; Indomethacin / pharmacology; Intestinal Mucosa / blood supply; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Ischemia / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / physiology; Male; Nitrobenzenes / pharmacology; Permeability; Prostaglandin-Endoperoxide Synthases / physiology; Sulfonamides / pharmacology; Swine
TL;DR:
The results suggest that recovery of resistance is triggered by PGE and PGI2, which may be elaborated by either COX-1 orCOX-2.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2002 review
Role of the enteric nervous system in the pathophysiology of secretory diarrhea
[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 16(3), 222–228.
author keywords: alimentary; enterocolitis; inflammation; neuroimmune
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Role of the enteric nervous system in the pathophysiology of secretory diarrhea
Journal of Veterinary Internal Medicine, 16(3), 222–228. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036581818&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2002 journal article
Surgical and postoperative factors influencing short-term survival of horses following small intestinal resection: 92 Cases (1994-2001)
Equine Veterinary Journal, 34(5), 450–454. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036632826&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2002 article
Surgical and postoperative factors influencing short-term survival of horses following small intestinal resection: 92 cases (1994-2001)
Morton, A. J., & Blikslager, A. T. (2002, July). EQUINE VETERINARY JOURNAL, Vol. 34, pp. 450–454.
author keywords: horse; jejunojejunostomy; jejunocaecostomy; strangulating obstruction; postoperative ileus
MeSH headings : Anastomosis, Surgical / mortality; Anastomosis, Surgical / veterinary; Animals; Confidence Intervals; Female; Horse Diseases / mortality; Horse Diseases / surgery; Horses; Intestinal Obstruction / epidemiology; Intestinal Obstruction / mortality; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Intestine, Small / surgery; Male; Odds Ratio; Postoperative Complications / epidemiology; Postoperative Complications / mortality; Postoperative Complications / veterinary; Postoperative Period; Retrospective Studies; Risk Factors; Survival Rate; Time Factors
TL;DR:
Clinicians should be aware of the factors associated with the greatest likelihood of nonsurvival following small intestinal resection, so that they can institute aggressive treatment and accurately inform owners on the likelihood of survival.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 article
The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon
Campbell, N. B., Jones, S. L., & Blikslager, A. T. (2002, July). EQUINE VETERINARY JOURNAL, Vol. 34, pp. 493–498.
author keywords: horse; colon; mucosa; cyclo-oxygenase; flunixin; etodolac
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Clonixin / administration & dosage; Clonixin / adverse effects; Clonixin / analogs & derivatives; Colitis / chemically induced; Colitis / veterinary; Colon / drug effects; Colon / pathology; Colon / physiopathology; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / administration & dosage; Cyclooxygenase Inhibitors / adverse effects; Deoxycholic Acid / adverse effects; Etodolac / administration & dosage; Etodolac / adverse effects; Horse Diseases / chemically induced; Horses; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Isoenzymes / metabolism; Permeability; Prostaglandin Antagonists / administration & dosage; Prostaglandin Antagonists / adverse effects; Prostaglandin-Endoperoxide Synthases / metabolism; Prostaglandins / biosynthesis
TL;DR:
Although recovery from bile-induced colonic injury maybe independent of COX-elaborated prostanoids, treatment of control tissues with nonselective COX inhibitors may lead to marked increases in permeability, and selective inhibition ofCOX-2 may reduce the incidence of adverse effects in horses requiring NSAID therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The effects of cyclo-oxygenase inhibitors on bile-injured and normal equine colon
Equine Veterinary Journal, 34(5), 493–498. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036634884&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2001 journal article
Deep digital flexor tenotomy for treatment of severe laminitis in a cow
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 219(5), 644–646.
MeSH headings : Animals; Cattle; Cattle Diseases / etiology; Cattle Diseases / surgery; Chronic Disease; Edema / complications; Edema / therapy; Edema / veterinary; Female; Foot Diseases / etiology; Foot Diseases / surgery; Foot Diseases / veterinary; Hoof and Claw; Lameness, Animal / etiology; Lameness, Animal / surgery; Mastitis, Bovine / complications; Mastitis, Bovine / therapy; Tendons / surgery
TL;DR:
A first-calf Guernsey cow was referred for evaluation of severe udder edema, mastitis, metritis, and ketosis and a deep digital flexor tenotomy was performed in the affected claws, providing almost immediate relief of signs of foot pain.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Deep digital flexor tenotomy for treatment of severe laminitis in a cow
Journal of the American Veterinary Medical Association, 219(5), 644–646+613. http://www.scopus.com/inward/record.url?eid=2-s2.0-0040621851&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2001 journal article
Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis
American Journal of Physiology-Gastrointestinal and Liver Physiology, 281(3), G645–G653.
Contributors: * , E. Hunt n, R. Guerrant*, M. Rhoads * & R. Argenzio*
author keywords: sodium absorption; sodium/hydrogen exchanger; villous atrophy; crypt hyperplasia; prostaglandin E-2
MeSH headings : Amino Acid Transport Systems; Amino Acid Transport Systems, Basic; Animals; Blotting, Western; Carrier Proteins / metabolism; Cattle; Chlorides / metabolism; Cryptosporidiosis / drug therapy; Cryptosporidiosis / pathology; Cryptosporidiosis / physiopathology; Cyclooxygenase Inhibitors / pharmacology; Dinoprostone / pharmacology; Dipeptides / pharmacology; Disease Models, Animal; Drug Synergism; Glutamine / pharmacology; Ileum / parasitology; Ileum / pathology; Ileum / physiopathology; Immunohistochemistry; In Vitro Techniques; Indomethacin / antagonists & inhibitors; Indomethacin / pharmacology; Intestinal Absorption / drug effects; Ion Transport / drug effects; Sodium / metabolism
TL;DR:
It is illustrated that the combined use of a PG synthesis inhibitor and glutamine can fully stimulate Na(+) and Cl(-) absorption despite the severe villous atrophy, an effect associated with increased expression of a Na(+)-dependent amino acid transporter in infected crypts.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2001 journal article
Neodymium: yttrium aluminum garnet laser ablation of a urethral web to relieve urinary outflow obstruction in a horse
Journal of the American Veterinary Medical Association, 218(12), 1970–1972.
MeSH headings : Animals; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Hysteroscopy / veterinary; Laser Therapy / veterinary; Male; Urethra / microbiology; Urethra / pathology; Urethral Obstruction / surgery; Urethral Obstruction / veterinary; Urinary Catheterization / veterinary
TL;DR:
The proximal location of the urethral lesion in this horse would have made use of traditional surgical methods problematic, whereas transendoscopic laser photoablation was easy and effective.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2001 journal article
Neodymium:Yttrium-aluminum-garnet laser ablation of a urethral web to relieve urinary outflow obstruction in a horse
Journal of the American Veterinary Medical Association, 218(12), 1970–1972. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035877844&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2001 journal article
PGE2 triggers recovery of transmucosal resistance via EP receptor cross talk in porcine ischemia-injured ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 281(2), G375–G381.
Contributors: n , S. Pell n & K. Young n
author keywords: mucosa; barrier function; adenosine 3 ' 5 '-cyclic monophosphate; G protein; short-circuit current
MeSH headings : Animals; Calcimycin / pharmacology; Calcium Signaling; Culture Techniques; Cyclic AMP / biosynthesis; Dinoprostone / analogs & derivatives; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Ileal Diseases / physiopathology; Indomethacin / pharmacology; Intestinal Mucosa / physiopathology; Ionophores / pharmacology; Ischemia / physiopathology; Male; Receptor Cross-Talk; Receptors, Prostaglandin E / antagonists & inhibitors; Receptors, Prostaglandin E / metabolism; Swine
TL;DR:
Treatment of tissues with deoxy-PGE1 and the Ca(2+) ionophore A-23187 stimulated synergistic increases in R and cAMP, indicating that PGE2 triggers recovery of R via EP receptor cross talk mechanisms involving cAMP and intracellular Ca( 2+).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2001 conference paper
Preliminary report: Comparison of 980-nm, 808-nm diode laser enhanced with Indocyanine green to the Nd: YAG laser applied to equine respiratory tissue
Proceedings of SPIE - The International Society for Optical Engineering, 4244, 583–590.
author keywords: chromophore; indocyanine green; diode laser; equine; Nd : YAG laser
TL;DR:
The depths and widths of penetration achieved with the 808-nm diode laser after intravenous injection of ICG on equine respiratory tissue are compared to themselves and to the Nd:YAG laser with all factors remaining constant.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 3, 2019
2001 journal article
Risk factors for reduced postoperative fecal output in horses: 37 cases (1997-1998)
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 218(3), 414–420.
Contributors: D. Little n, W. Redding* & *
MeSH headings : Anesthesia / veterinary; Animals; Colic / complications; Colic / veterinary; Defecation / physiology; Female; Horse Diseases / etiology; Horse Diseases / pathology; Horses; Intestinal Obstruction / etiology; Intestinal Obstruction / pathology; Intestinal Obstruction / veterinary; Logistic Models; Male; Orthopedics / veterinary; Postoperative Complications / etiology; Postoperative Complications / pathology; Postoperative Complications / veterinary; Prevalence; Regression Analysis; Retrospective Studies; Risk Factors
TL;DR:
Results suggest that after surgery unrelated to the gastrointestinal tract in horses, there is an intermediate clinical phase characterized by reduced fecal output preceding overt signs of colic, which may reduce morbidity and mortality of such horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2001 chapter
Surgical Disorders of the Large Intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (pp. 662–665). St. Louis, MO: Mosby.
Ed(s): B. Smith
Source: NC State University Libraries
Added: October 18, 2020
2001 chapter
Surgical Disorders of the Small Intestine
In B. P. Smith (Ed.), Large Animal Internal Medicine (pp. 649–653). St. Louis, MO: Mosby.
Ed(s): B. Smith
Source: NC State University Libraries
Added: October 18, 2020
2001 journal article
The future of antiinflammatory therapy
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 17(2), 245-+.
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Cell Adhesion Molecules; Cyclooxygenase Inhibitors / therapeutic use; Horse Diseases / drug therapy; Horses; Inflammation / drug therapy; Inflammation / veterinary; Inflammation Mediators
TL;DR:
These areas of antiinflammatory research are rapidly yielding drugs with diverse future applications in equine medicine, and new pharmacologic agents that specifically target prostanoid mediators of inflammation by specifically inhibiting the activity of cyclooxygenase 2 are potent antiinflammatory agents with fewer gastrointestinal side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
The future of antiinflammatory therapy.
The Veterinary Clinics of North America. Equine Practice, 17(2). http://www.scopus.com/inward/record.url?eid=2-s2.0-1942520108&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2000 journal article
Effects of feed physical form and buffering solutes on water disappearance and proximal stomach pH in swine.
Journal of Animal Science, 78(9), 2344.
Contributors: K. Ange n, J. Eisemann n, R. Argenzio n, G. Almond n & n
MeSH headings : Animal Feed; Animals; Buffers; Gastric Mucosa / metabolism; Hydrogen-Ion Concentration; Solutions; Swine / metabolism; Water / metabolism; Water Supply
TL;DR:
The effects of the physical form of feed on water disappearance and the effects of buffered water on proximal stomach pH in swine were determined in two experiments and the proximal pH of the stomach was increased by adding buffers to the water supply.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: NC State University Libraries, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum
American Journal of Physiology-Gastrointestinal and Liver Physiology, 278(2), G207–G216.
Contributors: * , M. Roberts*, K. Young*, J. Rhoads * & R. Argenzio n
author keywords: mucosa; chloride secretion; transmucosal resistance; tyrosine kinase
MeSH headings : 8-Bromo Cyclic Adenosine Monophosphate / pharmacology; Animals; Chlorides / metabolism; Cyclic GMP / pharmacology; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Female; Genistein / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / physiopathology; Intestinal Mucosa / physiopathology; Ischemia / physiopathology; Male; Mannitol / metabolism; N-Formylmethionine Leucyl-Phenylalanine / pharmacology; Swine / physiology; Tetradecanoylphorbol Acetate / pharmacology; Tritium
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
2000 journal article
Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism
GASTROENTEROLOGY, 118(1), 90–100.
Contributors: J. Rhoads, R. Argenzio n, W. Chen, L. Graves, L. Licato*, n , J. Smith, J. Gatzy*, D. Brenner *
MeSH headings : Cell Division / drug effects; Cell Line; Cyclic AMP / analogs & derivatives; Cyclic AMP / metabolism; Cyclic AMP / pharmacology; DNA / biosynthesis; DNA / drug effects; Enzyme Activation / drug effects; Enzyme Inhibitors / pharmacology; Epidermal Growth Factor / metabolism; Epidermal Growth Factor / pharmacology; Flavonoids / pharmacology; Glutamine / metabolism; Glutamine / pharmacology; Intestinal Mucosa / metabolism; Intestines / cytology; MAP Kinase Signaling System / drug effects; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / metabolism; Oxygen Consumption / drug effects; Thionucleotides / pharmacology; Thymidine / metabolism
TL;DR:
In vitro kinase assays showed that glutamine signaling requires an intact ERK (extracellular signal-related kinase) pathway in unstarved cells and increased levels of intracellular cAMP inhibit ERKs but only partially reduce glutamine-stimulated proliferation in enterocytes adapted to low glutamine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
History, instrumentation, and techniques of flexible endoscopic laser surgery in horses
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 16(2), 251-+.
MeSH headings : Animals; Endoscopes / history; Endoscopes / veterinary; Endoscopy / history; Endoscopy / methods; Endoscopy / veterinary; Female Urogenital Diseases / surgery; Female Urogenital Diseases / veterinary; History, 19th Century; History, 20th Century; History, 21st Century; Horse Diseases / surgery; Horses / surgery; Laser Therapy / history; Laser Therapy / instrumentation; Laser Therapy / methods; Laser Therapy / veterinary; Male Urogenital Diseases; Respiratory Tract Diseases / surgery; Respiratory Tract Diseases / veterinary; Surgery, Veterinary / history; Surgery, Veterinary / instrumentation; Surgery, Veterinary / methods; Surgical Instruments / history; Surgical Instruments / veterinary
TL;DR:
There are clearly a number of applications for which flexible endoscopic laser surgery has become the state of the art in equine surgery, and the Nd:YAG laser seems to be the most versatile instrument for this type of surgery, but it is critical to understand the advantages and disadvantages of each laser technique.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
History, instrumentation, and techniques of flexible endoscopic laser surgery in horses.
The Veterinary Clinics of North America. Equine Practice, 16(2), 251–268. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342587507&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2000 journal article
Mesenteric rents as a source of small intestinal strangulation in horses: 15 cases (1990-1997)
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 216(9), 1446–1449.
MeSH headings : Animals; Female; Horse Diseases / etiology; Horse Diseases / mortality; Horse Diseases / surgery; Horses; Intestinal Obstruction / etiology; Intestinal Obstruction / mortality; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Intestine, Small; Male; Mesentery / injuries; Mesentery / surgery; Recurrence; Survival Rate
TL;DR:
Inability to reduce the intestinal obstruction, severe hemorrhage from the mesentery, and the length of intestine involved are the main factors that decrease survival rates in horses with small intestinal strangulation caused by mesenteric rents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
2000 conference paper
Pilot study: Intravenous use of indocyanine green as an enhancer for 808-nm diode laser application in the equine
Proceedings of SPIE - The International Society for Optical Engineering, 3907, 454–460. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033723469&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
2000 journal article
Role of neutrophils in intestinal mucosal injury
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 217(4), 498–500.
Contributors: J. Gayle n, * & S. Jones*
MeSH headings : Animals; Intestinal Mucosa / blood supply; Intestinal Mucosa / pathology; Ischemia / etiology; Ischemia / pathology; Neutrophils / physiology
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
The role of cyclooxygenase inhibitors in repair of ischaemic-injured jejunal mucosa in the horse.
Equine Veterinary Journal. Supplement, (32), 59–64.
Contributors: N. Campbell n & n
MeSH headings : Animals; Clonixin / analogs & derivatives; Clonixin / pharmacology; Clonixin / therapeutic use; Colic / prevention & control; Colic / veterinary; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Cyclooxygenase Inhibitors / therapeutic use; Etodolac / pharmacology; Etodolac / therapeutic use; Horse Diseases / prevention & control; Horses; Intestinal Mucosa / drug effects; Isoenzymes / antagonists & inhibitors; Jejunal Diseases / prevention & control; Jejunal Diseases / veterinary; Jejunum / blood supply; Jejunum / drug effects; Male; Prostaglandin Antagonists / pharmacology; Prostaglandin Antagonists / therapeutic use; Prostaglandin-Endoperoxide Synthases; Reperfusion Injury / veterinary
TL;DR:
It is suggested that specific COX-2 inhibitors may provide an advantageous alternative to nonspecific cyclooxygenase inhibitors in horses with colic.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2000 journal article
Vaccine-associated anaphylactic-like reaction in a horse
Compendium on Continuing Education for the Practicing Veterinarian, 22(1), 81–84. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348245852&partnerID=MN8TOARS
Contributors: D. Zimmel, , S. Jones , D. McFarlane & K. Young
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Cyclooxygenase-2 Inhibitors in Equine Practice
Compendium on Continuing Education for the Practicing Veterinarian, 21(6), 548–550. http://www.scopus.com/inward/record.url?eid=2-s2.0-0347120540&partnerID=MN8TOARS
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
1999 journal article
Glutamine and transforming growth factor-α stimulate extracellular regulated kinases and enhance recovery of villous surface area in porcine ischemic-injured intestine
Surgery, 125(2), 186–194.
Contributors: * , J. Rhoads, D. Bristol*, M. Roberts* & R. Argenzio*
TL;DR:
Glutamine plus TGF-alpha treatment restored mucosal architecture within 72 hours of severe ischemic injury associated with sustained elevations in ERK activity.
(via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
1999 conference paper
New therapies for calf diarrhea: therapy and prevention for the new millennium
Proceedings of the thirty second annual conference, American Association of Bovine Practitioners: September 23-26, 1999, Nashville, TN, 32, 118–122. Stillwater, OK: American Association of Bovine Practitioners.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Prostaglandin-induced recovery of barrier function in porcine ileum is triggered by chloride secretion
American Journal of Physiology-Gastrointestinal and Liver Physiology, 276(1), G28–G36.
Contributors: * , M. Roberts* & R. Argenzio n
author keywords: tight junction; ischemia; mucosa
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Amiloride / pharmacology; Animals; Bumetanide / pharmacology; Chlorides / antagonists & inhibitors; Chlorides / metabolism; Cyclic GMP / analogs & derivatives; Cyclic GMP / pharmacology; Cyclooxygenase Inhibitors / pharmacology; Electric Conductivity; Electric Impedance; Enzyme Inhibitors / pharmacology; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; Ileum / physiology; Indomethacin / pharmacology; Male; Ouabain / pharmacology; Permeability / drug effects; Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors; Swine
TL;DR:
PGs signal recovery of R via induction of Cl- secretion and inhibition of Na+ absorption, possibly by establishing a transmucosal osmotic gradient.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
1999 chapter
Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse
In P. D. R. T. S. Mair & A. M. Merritt (Eds.), Equine gastric ulceration (Equine veterinary journal supplement) (pp. 24–29). Suffolk, UK: British Equine Veterinary Association.
Ed(s): P. T. S. Mair & A. Merritt
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Role of duodenal reflux in nonglandular gastric ulcer disease of the mature horse.
Equine Veterinary Journal. Supplement, (29), 24–29. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033106966&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1999 journal article
The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine
EQUINE VETERINARY JOURNAL, 31(4), 331–335.
author keywords: horse; intestine; ischaemia; myeloperoxidase; lipid peroxidation
MeSH headings : Anastomosis, Surgical / veterinary; Animals; Follow-Up Studies; Horse Diseases / etiology; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Intestinal Mucosa / enzymology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Obstruction / complications; Intestinal Obstruction / pathology; Intestinal Obstruction / surgery; Intestinal Obstruction / veterinary; Intestine, Small / metabolism; Intestine, Small / pathology; Intestine, Small / surgery; Lipid Peroxidation; Peroxidase / metabolism; Reperfusion Injury / etiology; Reperfusion Injury / pathology; Reperfusion Injury / veterinary
TL;DR:
Evidence of serosal injury and neutrophil infiltration in the proximal jejunal resection margins may predispose horses to post operative adhesions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 journal article
The characteristics of intestinal injury peripheral to strangulating obstruction lesions in the equine small intestine
Equine Veterinary Journal, 31(4), 331–335. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033160429&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1999 journal article
Transendoscopic laser treatment of rostral displacement of the palatopharyngeal arch in four horses
JOURNAL OF CLINICAL LASER MEDICINE & SURGERY, 17(2), 49–52.
MeSH headings : Airway Obstruction / diagnosis; Airway Obstruction / etiology; Airway Obstruction / physiopathology; Airway Obstruction / surgery; Animals; Arytenoid Cartilage; Endoscopy / methods; Exercise Tolerance; Female; Horse Diseases / diagnosis; Horse Diseases / etiology; Horse Diseases / physiopathology; Horse Diseases / surgery; Horses; Laser Therapy / methods; Male; Palate, Soft / abnormalities; Palate, Soft / surgery; Pharynx / abnormalities; Pharynx / surgery; Prognosis; Respiratory Sounds / etiology; Treatment Outcome
TL;DR:
Rostral displacement of the palatopharyngeal arch may be corrected in standing horses using transendoscopic surgery, but despite successful ablation of displaced tissue the prognosis for athletic performance is poor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1998 conference paper
Development of a model to evaluate laser penetration in the equine using Nd:YAG laser as a standard
Proceedings of SPIE - The International Society for Optical Engineering, 3245, 407–416.
Source: ORCID
Added: September 3, 2019
1998 journal article
L-Glutamine and Transforming Growth Factor-α Enhance Recovery of Monoacylglycerol Acyltransferase and Diacylglycerol Acyltransferase Activity in Porcine Postischemic Ileum
Pediatric Research, 43(2), 227–233.
Contributors: N. Ahdieh*, n , B. Bhat*, R. Coleman *, R. Argenzio n & J. Rhoads*
MeSH headings : Acyltransferases / metabolism; Animals; Diacylglycerol O-Acyltransferase; Duodenum / enzymology; Glutamine / pharmacology; Ileum / blood supply; Ileum / drug effects; Ileum / enzymology; Ileum / pathology; Intestinal Mucosa / drug effects; Intestinal Mucosa / pathology; Ischemia / enzymology; Jejunum / enzymology; Male; Swine; Transforming Growth Factor alpha / pharmacology
TL;DR:
It is shown that intestinal MGAT and DGAT activities decrease after ischemic damage, yet recover rapidly in bowel exposed to Gln and/or TGF-α, which could improve the efficacy of enteral feeding in infants recovering from bowel damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
1998 journal article
Synergistic effect of hydrochloric acid and bile acids on the pars esophageal mucosa of the porcine stomach
American Journal of Veterinary Research, 59(9), 1170–1176. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032161874&partnerID=MN8TOARS
Contributors: J. Lang, , D. Regina, J. Eisemann & R. Argenzio
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1997 journal article
How important is intestinal reperfusion injury in horses?
Journal of the American Veterinary Medical Association, 211(11), 1387–1389. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031451722&partnerID=MN8TOARS
Contributors: , M. Roberts, M. Gerard & R. Argenzio
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1997 journal article
Is reperfusion injury an important cause of mucosal damage after porcine intestinal ischemia?
SURGERY, 121(5), 526–534.
Contributors: n , M. Roberts n, J. Rhoads n & R. Argenzio n
MeSH headings : Animals; Female; Intestinal Mucosa / enzymology; Intestinal Mucosa / pathology; Intestines / blood supply; Intestines / enzymology; Ischemia / complications; Ischemia / metabolism; Male; Peroxidases / metabolism; Reperfusion Injury / complications; Reperfusion Injury / metabolism; Swine; Xanthine Dehydrogenase / metabolism; Xanthine Oxidase / metabolism
TL;DR:
Reperfusion injury may not play an important role in intestinal injury under conditions of complete mesenteric ischemia and low-flow states in the pig, which may result from low xanthine oxidase-xanthine dehydrogenase levels, which are similar to those found in the human being.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: August 6, 2018
1997 journal article
Mechanisms of intestinal mucosal repair
Journal of the American Veterinary Medical Association, 211(11), 1437–1441. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030707695&partnerID=MN8TOARS
Contributors: & M. Roberts
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1997 journal article
Nitric oxide and the intestinal epithelial barrier: does it protect or damage the gut?
Journal of Pediatric Gastroenterology and Nutrition, 25(4), 439–440. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031253859&partnerID=MN8TOARS
Contributors: & M. Roberts
Sources: ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
Peptide YY inhibits intestinal Cl- secretion in experimental porcine cryptosporidiosis through a prostaglandin-activated neural pathway
Journal of Pharmacology and Experimental Therapeutics, 283(2), 692–697. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030832697&partnerID=MN8TOARS
Contributors: R. Argenzio, M. Armstrong, & J. Rhoads
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1997 journal article
Prostaglandins I2 and E2 have a synergistic role in rescuing epithelial barrier function in porcine ileum.
Journal of Clinical Investigation, 100(8), 1928–1933.
Contributors: n , M. Roberts*, J. Rhoads* & R. Argenzio*
author keywords: intestinal mucosa; ischemia; cAMP; calcium; tight junctions
MeSH headings : Animals; Cytoprotection; Dinoprostone / pharmacology; Drug Synergism; Electric Impedance; Epithelium / drug effects; Epithelium / metabolism; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Ileum / drug effects; Ileum / metabolism; In Vitro Techniques; Indomethacin / pharmacology; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Inulin / metabolism; Male; Permeability / drug effects; Reperfusion Injury / drug therapy; Swine
TL;DR:
It is concluded that PGE2 and PGI2 have a synergistic role in restoration of intestinal barrier function by increasing intracellular cAMP and Ca2+, respectively, which in turn signal cytoskeletal-mediated tight junction closure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018
1996 journal article
Colic associated with a jejunal diverticulum in a mature horse
Equine Veterinary Education, 8(3), 143–144. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030537582&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1996 journal article
Critical steps in managing equine rectal tears
Compendium on Continuing Education for the Practicing Veterinarian, 18(10), 1140–1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-0348248969&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1996 journal article
Jejunocolostomy or ileocolostomy for treatment of cecal impaction in horses: Nine cases (1985-1995)
Journal of the American Veterinary Medical Association, 209(7), 1287–1290. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030256305&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1995 journal article
Accuracy of clinicians in predicting site and type of lesion as well as outcome in horses with colic.
Journal of the American Veterinary Medical Association, 207(11), 1444–1447. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029446969&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1995 journal article
Avulsion of the origin of the peroneus tertius tendon in a foal
Journal of the American Veterinary Medical Association, 204(9), 1483–1485.
Source: NC State University Libraries
Added: October 18, 2020
1995 journal article
Intestinal Atresia in Horses
Compendium on Continuing Education for the Practicing Veterinarian, 17, 1510–1517.
Source: NC State University Libraries
Added: October 18, 2020
1995 journal article
Loop colostomy for treatment of grade-3 rectal tears in horses: seven cases (1983-1994)
Journal of the American Veterinary Medical Association, 207(9), 1201–1205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029411076&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1995 journal article
Repeat laparotomy for gastrointestinal disorders in cattle: 57 cases (1968-1992).
Journal of the American Veterinary Medical Association, 207(7), 939–943. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029391433&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1995 journal article
TRANSENDOSCOPIC LASER TREATMENT OF GUTTURAL POUCH TYMPANITES IN 8 FOALS
VETERINARY SURGERY, 24(5), 367–372.
Contributors: L. Tate n, n & E. Little n
MeSH headings : Airway Obstruction / physiopathology; Airway Obstruction / surgery; Airway Obstruction / veterinary; Aluminum; Animals; Endoscopy / methods; Endoscopy / veterinary; Female; Horse Diseases / physiopathology; Horse Diseases / surgery; Horses / physiology; Laser Therapy / veterinary; Male; Neodymium; Parotid Diseases / physiopathology; Parotid Diseases / surgery; Parotid Diseases / veterinary; Pharyngeal Diseases / physiopathology; Pharyngeal Diseases / surgery; Pharyngeal Diseases / veterinary; Recurrence; Yttrium
TL;DR:
Guttural pouch tympanites was diagnosed in eight foals with respiratory stridor and tympanic swelling in the parotid region, and three foals were treated by transendoscopic neodymium:yttrium aluminum garnet laser fenestration of the median septum between the guttural pouches.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: August 6, 2018
1995 journal article
Vagal indigestion
Journal of the American Veterinary Medical Association, 206(10), 1528.
Source: NC State University Libraries
Added: September 8, 2019
1995 journal article
Vagal indigestion.
Journal of the American Veterinary Medical Association, 206(10). http://www.scopus.com/inward/record.url?eid=2-s2.0-0029644874&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1994 journal article
Avulsion of the origin of the peroneus tertius tendon in a foal.
Journal of the American Veterinary Medical Association, 204(9), 1483–1485. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028434716&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1994 journal article
Evaluation of factors associated with postoperative ileus in horses: 31 cases (1990-1992)
Journal of the American Veterinary Medical Association, 205(12), 1748–1752. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028774741&partnerID=MN8TOARS
Contributors: , K. Bowman, J. Levine , D. Bristol & M. Roberts
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
1994 journal article
Holding power of orthopedic screws in the large metacarpal and metatarsal bones of calves.
American Journal of Veterinary Research, 55(3), 415–418. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028390063&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1994 journal article
Recurrence of avulsion fractures.
Journal of the American Veterinary Medical Association, 205(4). http://www.scopus.com/inward/record.url?eid=2-s2.0-0028774119&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1993 journal article
Effects of Neodymium:Yttnum Aluminum Garnet Laser Irradiation on Endometrium and on Endometrial Cysts in Six Mares
Veterinary Surgery, 22(5), 351–356.
Contributors: n , L. Tate n & D. Weinstock n
MeSH headings : Animals; Cysts / pathology; Cysts / surgery; Cysts / veterinary; Endometrium / pathology; Endometrium / surgery; Female; Horse Diseases / pathology; Horse Diseases / surgery; Horses; Laser Therapy / veterinary; Treatment Outcome; Uterine Diseases / pathology; Uterine Diseases / surgery; Uterine Diseases / veterinary
TL;DR:
Two of the four mares that were reproductively sound but barren, despite appropriate breeding, produced foals after treatment, and another mare that was treated postpartum was bred successfully.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 3, 2019
1993 journal article
Surgical management of urolithiasis in small ruminants.
The Cornell Veterinarian, 83(1), 47–55. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027342746&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1992 journal article
EXCRETORY UROGRAPHY AND ULTRASONOGRAPHY IN THE DIAGNOSIS OF BILATERAL ECTOPIC URETERS IN A FOAL
Veterinary Radiology Ultrasound, 33(1), 41–47.
TL;DR:
This case establishes the value of diagnostic imaging techniques in the antemortem diagnosis of ectopic ureter in a 7-week-old Appaloosa filly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019
1992 journal article
Ectopic ureter in horses
Compendium on Continuing Education for the Practicing Veterinarian, 14, 802–807.
Source: NC State University Libraries
Added: October 18, 2020
1992 journal article
Excision of the distal sesamoid bone for treatment of infection of the digit in a heifer
Journal of the American Veterinary Medical Association, 201(12), 1905–1906. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027097511&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1992 journal article
Mycoplasma mycoides subspecies mycoides as the cause of a subauricular abscess and mastitis in a goat
Journal of the American Veterinary Medical Association, 201(9), 1404–1406. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027056779&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1992 journal article
Pedunculated lipomas as a cause of intestinal obstruction in horses: 17 cases (1983-1990).
Journal of the American Veterinary Medical Association, 201(8), 1249–1252. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027121071&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1991 journal article
Atlantoaxial malformation in a half-Arabian colt.
The Cornell Veterinarian, 81(1), 67–75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025929097&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
1991 journal article
Salmonella typhimurium abscess as a postoperative complication in a horse with colic
Journal of the American Veterinary Medical Association, 199(12), 1757–1759. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026323796&partnerID=MN8TOARS
Sources: ORCID, NC State University Libraries
Added: September 3, 2019
1991 journal article
What is your diagnosis? Collapsed trachea from the level of C5 to C7.
Journal of the American Veterinary Medical Association, 199(5), 629–630. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026217406&partnerID=MN8TOARS
Source: ORCID
Added: September 3, 2019
journal article
Abomasal impaction in cattle
Blikslager, A. T., Bristol, D. G., & Hunt, E. L. Compendium on Continuing Education for the Practicing Veterinarian, 15, 1571–1576.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Accuracy of clinicians in predicting site and type of lesion as well as outcome in horses with colic
Blikslager, A. T., & Roberts, M. C. Journal of the American Veterinary Medical Association, 207(11), 1444.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Avulsion of the origin of the peroneus tertius in a foal
Blikslager, A. T., & Bristol, D. G. Journal of the American Veterinary Medical Association, 204, 1483–1485.
Source: NC State University Libraries
Added: August 6, 2018
review
Bovine immunoglobulin protein isolates for the nutritional management of enteropathy
Petschow, B. W., Blikslager, A. T., Weaver, E. M., Campbell, J. M., Polo, J., Shaw, A. L., … Rhoads, J. M. [Review of ]. World Journal of Gastroenterology, 20(33), 11713–11726.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Critical steps in managing equine rectal tears
Blikslager, A. T., Roberts, M. C., & Mansmanr, R. A. Compendium on Continuing Education for the Practicing Veterinarian, 18(10), 1140.
Source: NC State University Libraries
Added: August 6, 2018
chapter
Disorders of the esophagus
Blikslager, A. T., & Jones, S. L. In Large animal internal medicine (3rd Ed.) (pp. 607–617). St. Louis: Mosby.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Equine colic
Blikslager, A. T. Ippologia, 19(3), 21–33.
Source: NC State University Libraries
Added: August 6, 2018
chapter
Esophageal diseases
Jones, S. L., & Blikslager, A. T. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 855–863). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
journal article
Gastro protective properties of the novel prostone SPI-8811 against acid-injured porcine mucosa
Nighot, M., Moeser, A., Ueno, R., & Blikslager, A. World Journal of Gastroenterology, 18(34), 4684–4692.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Holding power of orthopedic screws in the large metacarpal and metatarsal bones of calves
Blikslager, A. T., Bowman, K. F., Abrams, C. F., Jr., Seaboch, T. R., & Hunt, E. L. American Journal of Veterinary Research, 55(3), 415.
Source: NC State University Libraries
Added: August 6, 2018
chapter
Ischemic disorders of the intestinal tract
Blikslager, A. T., & Jones, S. L. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 913–922). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
journal article
Jejunocolostomy or ileocolostomy for treatment of cecal impaction in horses: Nine cases (1985-1995)
Gerard, M. P., Bowman, K. F., Blikslager, A. T., Tate, L. P., Jr., & Bristol, D. G. Journal of the American Veterinary Medical Association, 209(7), 1287–1289.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Loop colostomy for treatment of grade-3 rectal tear in horses: Seven cases (1983-1994)
Blikslager, A. T., Bristol, D. G., Bowman, K. F., & Engelbert, T. A. Journal of the American Veterinary Medical Association, 207(9), 1201–1205.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Management of pain in horses with colic
Blikslager, A. T. Compendium's Standards of Care. Emergency and Critical Care Medicine, 1, 7–12.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Mycoplasma mycoides subspecies mycoides as the cause of a subauricular abscess and mastitis in a goat
Blikslager, A. T., & Anderson, K. L. Journal of the American Veterinary Medical Association, 201(9), 1404.
Source: NC State University Libraries
Added: August 6, 2018
chapter
Obstructive disorders of the intestinal tract
Blikslager, A. T., & Jones, S. L. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 922–936). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
chapter
Pathophysiology of mucosal injury and repair
Blikslager, A. T. In W. M. B. S. M. Reed & D. C. Sellon (Eds.), Equine internal medicine (pp. 802–815). Philadelphia: W. B. Saunders.
Ed(s): W. S. M. Reed & D. Sellon
Source: NC State University Libraries
Added: August 6, 2018
chapter
Pathophysiology of the gastronintestinal tract
Blikslager, A. T., Jones, S. L., Grondhal, M. L., Merritt, A. M., & Malbert, C. H. In R. H. Dunlop & C. H. Malbert (Eds.), Veterinary pathophysiology (pp. 111–142). Ames, IA: Blackwell Pub.
Ed(s): . R. H. Dunlop & C. Malbert
Source: NC State University Libraries
Added: August 6, 2018
journal article
Pedunculated lipomas as a cause of intestinal obstruction in horses 17 cases (1983-1990)
Blikslager, A. T., Bowman, K. F., Haven, M. L., Tate, L. P., Jr., & Bristol, D. G. Journal of the American Veterinary Medical Association, 201(8), 1249–1252.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Recurrence of avulsion fractures
Blikslager, A. T., & Bristol, D. G. Journal of the American Veterinary Medical Association, 205, 534.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Repeat laparotomy for gastrointestinal disorders in cattle: 57 cases (1968-1992)
Blikslager, A. T., Anderson, K. L., Bristol, D. G., Fubini, S., & Anderson, D. E. Journal of the American Veterinary Medical Association, 207(7), 939–943.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Treatment of ischemic intestinal disease
Blikslager, A. T. Veterinary Clinics of North America. Equine Practice, 715–728.
Source: NC State University Libraries
Added: August 6, 2018
personal communication
Views conclusions in ultrasound study as unsupported
Pease, A., Cook, V., Jones, S., Blikslager, A., Scrivani, P., & Erb, H.
Source: NC State University Libraries
Added: August 6, 2018
journal article
What COX-1 and COX-2 do and how they differ
Blikslager, A. T. Veterinary Forum, 23–28.
Source: NC State University Libraries
Added: August 6, 2018
journal article
surgical tendonitis model in horses: Techinque, clinical, ultrasonographic and histological characterisation
Schramme, M., Hunter, S., Campbell, N., Blikslager, A., & Smith, R. Veterinary and Comparative Orthopaedics and Traumatology, 23(4), 231–239.
Source: NC State University Libraries
Added: August 6, 2018
Employment
Updated: October 5th, 2016 18:36
2008 - present
North Carolina State University Raleigh, NC, US
Professor of Equine Surgery and Gastroenterology
Clinical Sciences
1990 - 1994
North Carolina State University Raleigh, NC, US
Resident, Large Animal Surgery
Veterinary Teaching Hospital
1989 - 1990
University of Missouri Columbia Columbia, MO, US
Intern
Equine Medical Center
Education
Updated: October 5th, 2016 18:25
1994 - 1997
North Carolina State University Raleigh, NC, US
PhD, Gastrointestinal Physiology
Food Animal and Equine
1985 - 1989
Virginia Polytechnic Institute and State University Blacksburg, VA, US
DVM
Virginia-Maryland College of Veterinary Medicine
1982 - 1986
Virginia Polytechnic Institute and State University Blacksburg, VA, US
BS, Biochemistry
Biochemistry
Funding History
Funding history based on the linked ORCID record. Updated: October 5th, 2016 18:29
grant
September 15, 2006 - July 31, 2016
Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
National Institute of Diabetes and Digestive and Kidney Diseases
grant
August 5, 1998 - November 30, 2003
MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
National Institute of Diabetes and Digestive and Kidney Diseases
grant
September 1, 1996
MECHANISMS OF REPAIR OF ISCHEMIC INJURED INTESTINE
National Institute of Diabetes and Digestive and Kidney Diseases
Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.
Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.