Adam T. Melvin

Works (4)

Updated: August 17th, 2023 21:16

2013 article

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

Ott, L. E., Sung, E. J., Melvin, A. T., Sheats, M. K., Haugh, J. M., Adler, K. B., & Jones, S. L. (2013, June 19). (P. Aspenstrom, Ed.). PLoS ONE, Vol. 8, p. e66512.

By: L. Ott n, E. Sung  n, A. Melvin n, M. Sheats n , J. Haugh n , K. Adler n, S. Jones n 

Ed(s): P. Aspenstrom

MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
topics (OpenAlex): Cellular Mechanics and Interactions; Protein Kinase Regulation and GTPase Signaling
TL;DR: Genetic structure-function analysis revealed that MANS peptide-mediated attenuation of NIH-3T3 cell migration does not require the presence of the myristic acid moiety on the amino-terminus, and suggests that MARCKS-mediated regulation of fibroblast migration involves the MARC KS amino- terminus. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 article

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

Welf, E. S., Ahmed, S., Johnson, H. E., Melvin, A. T., & Haugh, J. M. (2012, April 2). The Journal of Cell Biology, Vol. 197, pp. 105–114.

By: E. Welf n, S. Ahmed n, H. Johnson n, A. Melvin n & J. Haugh n 

MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
topics (OpenAlex): Cellular Mechanics and Interactions; Cancer Cells and Metastasis; Microtubule and mitosis dynamics
TL;DR: Migrating fibroblasts reorient directionality by PI3K-dependent branching and pivoting of protrusions, a mechanism that allows fibro Blasts to align with an external chemotactic gradient. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 article

In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling

Melvin, A. T., Welf, E. S., Wang, Y., Irvine, D. J., & Haugh, J. M. (2011, April 1). Biophysical Journal, Vol. 100, pp. 1893–1901.

By: A. Melvin n, E. Welf n, Y. Wang *, D. Irvine * & J. Haugh n 

MeSH headings : Alginates / chemistry; Animals; Cell Surface Extensions / drug effects; Cell Surface Extensions / metabolism; Chemotaxis / drug effects; Dose-Response Relationship, Drug; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Mice; Microspheres; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / chemistry; Platelet-Derived Growth Factor / pharmacology; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / drug effects; Stochastic Processes
topics (OpenAlex): Cellular Mechanics and Interactions; 3D Printing in Biomedical Research; Cancer Cells and Metastasis
TL;DR: It is shown that persistent and properly aligned (i.e., high-fidelity) fibroblast migration does indeed correlate with polarized PI3K signaling; accordingly, this behavior is seen only under conditions of high gradient steepness and a certain range of PDGF concentrations. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 article

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

Weiger, M. C., Wang, C.-C., Krajcovic, M., Melvin, A. T., Rhoden, J. J., & Haugh, J. M. (2009, January 6). Journal of Cell Science, Vol. 122, pp. 313–323.

By: M. Weiger n, C. Wang n, M. Krajcovic n, A. Melvin n, J. Rhoden n & J. Haugh n 

author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
topics (OpenAlex): Cellular Mechanics and Interactions; Hippo pathway signaling and YAP/TAZ; Cell Adhesion Molecules Research
TL;DR: Live-cell imaging using total internal reflection fluorescence (TIRF) microscopy revealed that, in the absence of soluble cues, 3′-phosphoinositides are enriched in a localized and dynamic fashion during active spreading and random migration of mouse fibroblasts on adhesive surfaces. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.