Works (4)
Updated: August 17th, 2023 21:16
2013 journal article
Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein
PLOS ONE, 8(6).
Ed(s): P. Aspenstrom
MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
TL;DR:
Genetic structure-function analysis revealed that MANS peptide-mediated attenuation of NIH-3T3 cell migration does not require the presence of the myristic acid moiety on the amino-terminus, and suggests that MARCKS-mediated regulation of fibroblast migration involves the MARC KS amino- terminus.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism
JOURNAL OF CELL BIOLOGY, 197(1), 105–114.
MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
TL;DR:
Migrating fibroblasts reorient directionality by PI3K-dependent branching and pivoting of protrusions, a mechanism that allows fibro Blasts to align with an external chemotactic gradient.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling
BIOPHYSICAL JOURNAL, 100(8), 1893–1901.
MeSH headings : Alginates / chemistry; Animals; Cell Surface Extensions / drug effects; Cell Surface Extensions / metabolism; Chemotaxis / drug effects; Dose-Response Relationship, Drug; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Mice; Microspheres; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / chemistry; Platelet-Derived Growth Factor / pharmacology; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / drug effects; Stochastic Processes
TL;DR:
It is shown that persistent and properly aligned (i.e., high-fidelity) fibroblast migration does indeed correlate with polarized PI3K signaling; accordingly, this behavior is seen only under conditions of high gradient steepness and a certain range of PDGF concentrations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 journal article
Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts
JOURNAL OF CELL SCIENCE, 122(3), 313–323.
author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
TL;DR:
Live-cell imaging using total internal reflection fluorescence (TIRF) microscopy revealed that, in the absence of soluble cues, 3′-phosphoinositides are enriched in a localized and dynamic fashion during active spreading and random migration of mouse fibroblasts on adhesive surfaces.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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