Adam T. Melvin

Works (4)

Updated: August 17th, 2023 21:16
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2013 journal article

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein

PLOS ONE, 8(6).

By: L. Ott n, E. Sung  n, A. Melvin n, M. Sheats n , J. Haugh n , K. Adler n, S. Jones n 

Ed(s): P. Aspenstrom

MeSH headings : 3T3 Cells; Animals; Becaplermin; Chemotaxis / drug effects; Chemotaxis / physiology; Collagen / metabolism; Fibroblasts / cytology; Fibronectins / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Membrane Proteins / metabolism; Membrane Proteins / physiology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Proto-Oncogene Proteins c-sis / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

JOURNAL OF CELL BIOLOGY, 197(1), 105–114.

By: E. Welf n, S. Ahmed n, H. Johnson n, A. Melvin n & J. Haugh n 

MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

In Chemotaxing Fibroblasts, Both High-Fidelity and Weakly Biased Cell Movements Track the Localization of PI3K Signaling

BIOPHYSICAL JOURNAL, 100(8), 1893–1901.

By: A. Melvin n, E. Welf n, Y. Wang *, D. Irvine * & J. Haugh n 

MeSH headings : Alginates / chemistry; Animals; Cell Surface Extensions / drug effects; Cell Surface Extensions / metabolism; Chemotaxis / drug effects; Dose-Response Relationship, Drug; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Glucuronic Acid / chemistry; Hexuronic Acids / chemistry; Mice; Microspheres; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / chemistry; Platelet-Derived Growth Factor / pharmacology; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / drug effects; Stochastic Processes
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts

JOURNAL OF CELL SCIENCE, 122(3), 313–323.

By: M. Weiger n, C. Wang n, M. Krajcovic n, A. Melvin n, J. Rhoden n & J. Haugh n 

author keywords: Cell migration; Phosphoinositide 3-kinase; Integrin; Fibronectin; Adhesion
MeSH headings : Actins / antagonists & inhibitors; Actins / metabolism; Animals; Chemotaxis / physiology; Cytochalasin D / pharmacology; Cytoskeleton / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Fibroblasts / physiology; Focal Adhesion Protein-Tyrosine Kinases / metabolism; Mice; Phosphatidylinositol 3-Kinases / metabolism; Platelet-Derived Growth Factor / metabolism; Pseudopodia / metabolism; Receptors, Platelet-Derived Growth Factor / metabolism; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: August 6, 2018