@article{bosscher_tomas_roe_marcellin-little_lascelles_2017, title={Repeatability and accuracy testing of a weight distribution platform and comparison to a pressure sensitive walkway to assess static weight distribution}, volume={30}, ISSN={["0932-0814"]}, url={https://dx.doi.org/10.3415/vcot-16-09-0128}, DOI={10.3415/vcot-16-09-0128}, abstractNote={Summary Objective: To evaluate the accuracy and repeatability of measurements collected using a weight distribution platform and a pressure sensitive walkway using an inanimate object with known weight distribution. Methods: A custom-built jig with a range of weights was applied in a random order. Measurements were collected on both devices and compared to each other and to the known weight distribution. Results: Weight distribution platform and pressure sensitive walkway measurements were highly correlated to each other (Pearson’s correlation coefficient R = 0.98) and to actual weights (R = 0.99 for the weight distribution platform; 0.98 for the pressure sensitive walkway). Repeatability from day to day for both devices was greater than 0.99. For the weight distribution platform, the 95% confidence interval was ± 2.5% from the true percentage and ± 3.3% for the pressure sensitive walkway. The coefficient of variation (COV) was highest for both devices at the lightest weights (weight distribution platform 11.28%, pressure sensitive walkway 16.91%) and lowest with the heaviest weights (weight distribution platform 3.71%, pressure sensitive walkway 5.86%). Conclusion: Both the weight distribution platform and the pressure sensitive walkway provided accurate and consistent measures of weight distribution with no significant difference between devices. The rounded standard error was three percent for the weight distribution platform, and four percent for the pressure sensitive walkway. The higher variability when measuring the smallest weight suggests less accuracy at lower weights with both devices. Clinical significance: The weight distribution platform is a repeatable and accessible device to measure static weight distribution, and if proven the same in a clinical setting, it will be a valuable addition to current objective measures of limb use.}, number={2}, journal={VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY}, publisher={Schattauer GmbH}, author={Bosscher, Georgia and Tomas, Andrea and Roe, Simon C. and Marcellin-Little, Denis J. and Lascelles, B. Duncan X.}, year={2017}, pages={160–164} }
 @article{tomas_bledsoe_wall_davidson_lascelles_2015, title={Initial evaluation of a canine stifle arthrotomy post-operative pain model}, volume={204}, ISSN={["1532-2971"]}, url={https://dx.doi.org/10.1016/j.tvjl.2015.03.010}, DOI={10.1016/j.tvjl.2015.03.010}, abstractNote={Most models of acute post-operative orthopedic pain involve the injection of a clinically irrelevant pro-inflammatory agent. The ideal model should, however, be clinically relevant and allow full functional recovery of enrolled animals after research is completed. This study explored the validity of a model employing arthrotomy and objectively measured limb use. Six purpose-bred Beagles underwent arthrotomies on each stifle with a washout period in between. Using a randomized crossover design, each dog received placebo and an extended-release buprenorphine (ER-Bup) preparation. Static and dynamic ground reaction forces (GRFs) were measured prior to and for 72 h following surgery using a pressure sensitive walkway (PSW). GRFs for each hind limb were compared using difference (delta), and symmetry indices (SI). The effects of surgery and of treatment were analyzed using repeated measures ANCOVA. The results indicated significantly decreased limb use compared to baseline for placebo, and significantly increased limb use in the ER-Bup group over placebo at all times for % bodyweight distribution (%BWdistrib), peak vertical force (PVF) and vertical impulse (VI). There was a significant treatment by time interaction for velocity (P = 0.03) and %BWdistrib (P = 0.01, 0.003). Overall, the data show that reduced limb use was present for at least 72 h following arthrotomy. In addition, the use of the ER-Bup analgesic decreased lameness, confirming the validity of this approach as a model of post-operative pain. Subjective assessments did not detect the pain-inducing effects of arthrotomy or pain-alleviating effects of treatment, and subjective measures of procedural pain in research dogs need to be developed.}, number={3}, journal={VETERINARY JOURNAL}, author={Tomas, A. and Bledsoe, D. and Wall, S. and Davidson, G. and Lascelles, B. D. X.}, year={2015}, month={Jun}, pages={293–298} }
 @article{knazovicky_tomas_motsinger-reif_lascelles_2015, title={Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain}, volume={3}, journal={PeerJ}, author={Knazovicky, D. and Tomas, A. and Motsinger-Reif, A. and Lascelles, B. D. X.}, year={2015} }
 @article{tomas_pultorak_gruen_breitschwerdt_lascelles_2014, title={Relationship Between Degenerative Joint Disease, Pain, and Bartonella spp. Seroreactivity in Domesticated Cats}, volume={29}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.12495}, DOI={10.1111/jvim.12495}, abstractNote={Background Recently, a potential association was identified between Bartonella exposure and arthritides in mammalian species other than cats. Hypothesis/Objectives We hypothesized that Bartonella exposure is associated with more severe degenerative joint disease (DJD) and a greater burden of DJD‐associated pain in client‐owned cats. Animals Ninety‐four client‐owned cats (6 months to 20 years old), ranging from clinically unaffected to severely lame because of DJD. Methods Using physical examination and radiography, pain and radiographic scores were assigned to each part of the bony skeleton. Sera were tested for Bartonella henselae, B. koehlerae, and B. vinsonii subsp. berkhoffii (genotypes I, II, and III) antibodies using immunofluorescence antibody assays. Variables were categorized and logistic regression used to explore associations. Results Seropositivity to Bartonella was identified in 33 (35.1%) cats. After multivariate analysis controlling for age, total DJD score (OR, 0.51; 95% CI, 0.26–0.97; P = .042), appendicular pain score (OR, 0.33; 95% CI, 0.17–0.65; P = .0011), and total pain score (OR, 0.35; 95% CI, 0.17–0.72; P = .0045) were significantly inversely associated with Bartonella seroreactivity status, indicating that cats with higher DJD and pain scores were less likely to be Bartonella seropositive. Conclusions and Clinical Importance Based upon this preliminary study, Bartonella spp. seropositivity was associated with decreased severity of DJD and decreased DJD‐associated pain in cats. Additional studies are needed to verify these findings, and if verified, to explore potential mechanisms.}, number={1}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Tomas, A. and Pultorak, E.L. and Gruen, M.E. and Breitschwerdt, E.B. and Lascelles, B.D.X.}, year={2014}, month={Oct}, pages={21–27} }
 @article{tomas_marcellin-little_roe_motsinger-reif_lascelles_2014, title={Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds}, volume={43}, ISSN={["1532-950X"]}, url={https://dx.doi.org/10.1111/j.1532-950x.2014.12160.x}, DOI={10.1111/j.1532-950x.2014.12160.x}, abstractNote={OBJECTIVES
To compare von Frey mechanical quantitative sensory thresholds (mQSTvF ) between pelvic limbs in dogs before unilateral total hip replacement (THR) surgery; to correlate ground reaction forces (GRF) with mQSTvF ; to assess changes in mQSTvF after THR surgery.


STUDY DESIGN
Prospective clinical study.


ANIMALS
Dogs (n = 44).


METHODS
mQSTvF and GRF measured using a pressure sensitive walkway were evaluated before, and 3, 6, and 12 months after, unilateral THR. Measurements were recorded from the affected (operated) pelvic limb (APL) and the non-operated pelvic limb (NPL). Random effects analysis and forwards stepwise linear regression models were used to evaluate the influence of time since surgery and patient factors on mQSTvF thresholds.


RESULTS
There were no significant correlations between mQSTvF data and age, bodyweight or the GRF variables. Preoperative mQSTvF measured at the APL and NPL did not differ (P = .909). mQSTvF thresholds increased significantly after 12 months in NPL (P = .047) and APL (P = .001). In addition to time, APL mQSTvF values were significantly affected by sex (higher in males, P = .010) and body condition score (higher in leaner dogs, P = .035) and NPL mQSTvF values by sex (P = .038).


CONCLUSION
Successful unilateral THR results in decreased central sensitization after 12 months.}, number={5}, journal={VETERINARY SURGERY}, author={Tomas, Andrea and Marcellin-Little, Denis J. and Roe, Simon C. and Motsinger-Reif, Alison and Lascelles, B. Duncan X.}, year={2014}, month={Jul}, pages={542–548} }