@article{bosscher_tomas_roe_marcellin-little_lascelles_2017, title={Repeatability and accuracy testing of a weight distribution platform and comparison to a pressure sensitive walkway to assess static weight distribution}, volume={30}, ISSN={["0932-0814"]}, url={https://dx.doi.org/10.3415/vcot-16-09-0128}, DOI={10.3415/vcot-16-09-0128}, abstractNote={Summary}, number={2}, journal={VETERINARY AND COMPARATIVE ORTHOPAEDICS AND TRAUMATOLOGY}, publisher={Schattauer GmbH}, author={Bosscher, Georgia and Tomas, Andrea and Roe, Simon C. and Marcellin-Little, Denis J. and Lascelles, B. Duncan X.}, year={2017}, pages={160–164} } @article{tomas_bledsoe_wall_davidson_lascelles_2015, title={Initial evaluation of a canine stifle arthrotomy post-operative pain model}, volume={204}, ISSN={["1532-2971"]}, url={https://dx.doi.org/10.1016/j.tvjl.2015.03.010}, DOI={10.1016/j.tvjl.2015.03.010}, abstractNote={Most models of acute post-operative orthopedic pain involve the injection of a clinically irrelevant pro-inflammatory agent. The ideal model should, however, be clinically relevant and allow full functional recovery of enrolled animals after research is completed. This study explored the validity of a model employing arthrotomy and objectively measured limb use. Six purpose-bred Beagles underwent arthrotomies on each stifle with a washout period in between. Using a randomized crossover design, each dog received placebo and an extended-release buprenorphine (ER-Bup) preparation. Static and dynamic ground reaction forces (GRFs) were measured prior to and for 72 h following surgery using a pressure sensitive walkway (PSW). GRFs for each hind limb were compared using difference (delta), and symmetry indices (SI). The effects of surgery and of treatment were analyzed using repeated measures ANCOVA. The results indicated significantly decreased limb use compared to baseline for placebo, and significantly increased limb use in the ER-Bup group over placebo at all times for % bodyweight distribution (%BWdistrib), peak vertical force (PVF) and vertical impulse (VI). There was a significant treatment by time interaction for velocity (P = 0.03) and %BWdistrib (P = 0.01, 0.003). Overall, the data show that reduced limb use was present for at least 72 h following arthrotomy. In addition, the use of the ER-Bup analgesic decreased lameness, confirming the validity of this approach as a model of post-operative pain. Subjective assessments did not detect the pain-inducing effects of arthrotomy or pain-alleviating effects of treatment, and subjective measures of procedural pain in research dogs need to be developed.}, number={3}, journal={VETERINARY JOURNAL}, author={Tomas, A. and Bledsoe, D. and Wall, S. and Davidson, G. and Lascelles, B. D. X.}, year={2015}, month={Jun}, pages={293–298} } @article{knazovicky_tomas_motsinger-reif_lascelles_2015, title={Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain}, volume={3}, journal={PeerJ}, author={Knazovicky, D. and Tomas, A. and Motsinger-Reif, A. and Lascelles, B. D. X.}, year={2015} } @article{tomas_pultorak_gruen_breitschwerdt_lascelles_2014, title={Relationship Between Degenerative Joint Disease, Pain, and Bartonella spp. Seroreactivity in Domesticated Cats}, volume={29}, ISSN={0891-6640}, url={http://dx.doi.org/10.1111/jvim.12495}, DOI={10.1111/jvim.12495}, abstractNote={BackgroundRecently, a potential association was identified between Bartonella exposure and arthritides in mammalian species other than cats.}, number={1}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Tomas, A. and Pultorak, E.L. and Gruen, M.E. and Breitschwerdt, E.B. and Lascelles, B.D.X.}, year={2014}, month={Oct}, pages={21–27} } @article{tomas_marcellin-little_roe_motsinger-reif_lascelles_2014, title={Relationship Between Mechanical Thresholds and Limb Use in Dogs With Coxofemoral Joint OA-Associated Pain and the Modulating Effects of Pain Alleviation From Total Hip Replacement on Mechanical Thresholds}, volume={43}, ISSN={["1532-950X"]}, url={https://dx.doi.org/10.1111/j.1532-950x.2014.12160.x}, DOI={10.1111/j.1532-950x.2014.12160.x}, abstractNote={ObjectivesTo compare von Frey mechanical quantitative sensory thresholds (mQSTvF) between pelvic limbs in dogs before unilateral total hip replacement (THR) surgery; to correlate ground reaction forces (GRF) with mQSTvF; to assess changes in mQSTvF after THR surgery.}, number={5}, journal={VETERINARY SURGERY}, author={Tomas, Andrea and Marcellin-Little, Denis J. and Roe, Simon C. and Motsinger-Reif, Alison and Lascelles, B. Duncan X.}, year={2014}, month={Jul}, pages={542–548} }