Andrew Thomas Steinhauer

Works (2)

Updated: July 5th, 2023 15:50

2009 article

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

Huigens, R. W., III, Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, January 1). Organic & Biomolecular Chemistry.

By: R. Huigens n, S. Rogers n, A. Steinhauer n & C. Melander n

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Biofilms / drug effects; Imidazoles / chemistry; Pseudomonas aeruginosa / drug effects; Small Molecule Libraries / chemical synthesis; Staphylococcus aureus / drug effects; Triazoles / chemical synthesis
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
TL;DR: A chemically diverse library of TAGE-triazole conjugates synthesized utilizing click chemistry on the TAGE scaffold demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Huigens, R. W., Reyes, S., Reed, C. S., Bunders, C., Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, December 7). Bioorganic & Medicinal Chemistry.

By: R. Huigens n, S. Reyes n, C. Reed n, C. Bunders n, S. Rogers n, A. Steinhauer n, C. Melander n

author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
topics (OpenAlex): Synthesis and biological activity; Phenothiazines and Benzothiazines Synthesis and Activities; Antimicrobial Peptides and Activities
TL;DR: These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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